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https://www.readbyqxmd.com/read/29346407/relaxin-reverses-inflammatory-and-immune-signals-in-aged-hearts
#1
Brian Martin, Beth Ann Gabris-Weber, Rajiv Reddy, Guillermo Romero, Ansuman Chattopadhyay, Guy Salama
BACKGROUND: 'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive remodeling in aging and HF...
2018: PloS One
https://www.readbyqxmd.com/read/29344447/successful-management-of-right-ventricular-perforation-associated-with-a-pacemaker-lead-during-off-pump-cabg-surgery-a-case-report
#2
Masoud Tarbiat, Mohammad Hossein Bakhshaei, Mehdi Moradi
Introduction: Intraoperative right ventricular perforation due to pacing catheter after its successful and uneventful insertion is a rare complication. Here, we present a case of cardiac arrest due to right ventricular perforation associated with a pacemaker lead during off-pump coronary artery bypass graft surgery. Case Presentation: The case was a 68-year-old male, who was admitted to our hospital with retrosternal chest pain. He had a history of implantation of a permanent pacemaker due to symptomatic complete atrioventricular block...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29343857/stimulation-of-epicardial-sympathetic-nerves-at-different-sites-induces-cardiac-electrical-instability-to-various-degrees
#3
Liang Wang, Lin Sun, Kun Wang, Yingying Jin, Qing Liu, Zhongnan Xia, Xudong Liu, Jiakun Zhang, Jingjie Li
The cardiac sympathetic nerves distribute across cardiac tissues with uneven density. Yet, to what extent this anatomical heterogeneity affects electrical activity of the left ventricle is largely unknown. Dogs were randomized into non-stimulation control (NC), posterior basal-stimulation (PB), anterior superior-stimulation (AS), apical part-stimulation (AP) group. The epicardial sympathetic nerves at different sites along their distribution were with electrical stimulation (ES) for 4 hours except in the NC group...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342992/-radiofrequency-catheter-ablation-of-premature-ventricular-contractions-in-children-under-carto3-system-a-retrospective-study-from-one-single-center
#4
W Ji, J J Wu, Y J Qian, Y W Chen, L J Fu, J Shen, F Li
Objective: To evaluate the clinical effect and summarize the experience of radiofrequency catheter ablation (RFCA) for children suffered from premature ventricular contractions (PVCs). Methods: This retrospective study was conducted by descriptive analysis. A total of 108 cases with frequent PVCs from Shanghai Children's Medical Center were treated with RFCA under the guidance of CARTO3 system from January 2011 to December 2016. The immediate success rate of the procedure, the recurrence rate and the perioperative complications were summarized...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29340889/quantification-of-myocardial-perfusion-defect-size-in-rats-comparison-between-quantitative-perfusion-spect-and-autoradiography
#5
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
PURPOSE: Ultra-high resolution single-photon emission computed tomography (SPECT) system, using multiple pinhole collimators, has been applied to the imaging of small rodents. We aimed to compare the myocardial infarction (MI) area on quantitative perfusion single-photon emission computed tomography (QPS; Cedars-Sinai Medical Center, USA) with that on high-resolution autoradiography in rat model to determine the accuracy of perfusion defect measurement by QPS. PROCEDURES: After thoracotomy, rats (n = 9) had their left coronary arteries occluded and reperfused before injection with 185 MBq [99mTc] methoxyisobutylisonitrile ([99mTc]MIBI) for SPECT and autoradiography...
January 16, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29340527/cardiac-protein-expression-patterns-are-associated-with-distinct-inborn-exercise-capacity-in-non-selectively-bred-rats
#6
L P Ribeiro, L C Freitas-Lima, G B Naumann, S S Meyrelles, W Lunz, S F Pires, H M Andrade, J B T Carnielli, S G Figueiredo
In the present study, we successfully demonstrated for the first time the existence of cardiac proteomic differences between non-selectively bred rats with distinct intrinsic exercise capacities. A proteomic approach based on two-dimensional gel electrophoresis coupled to mass spectrometry was used to study the left ventricle (LV) tissue proteome of rats with distinct intrinsic exercise capacity. Low running performance (LRP) and high running performance (HRP) rats were categorized by a treadmill exercise test, according to distance run to exhaustion...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29339701/subclinical-reduction-in-left-ventricular-function-using-triplane-and-2d-speckle-tracking-echocardiography-after-anthracycline-exposure-in-children
#7
Erman Çilsal, Ayşe Deniz Oğuz, Fatma Sedef Tunaoğlu, Serdar Kula, Ayhan Pektaş
OBJECTIVE: Speckle tracking echocardiography (STE) enables global and regional evaluation of the left ventricle (LV); therefore, it is the most useful method for detecting subclinical dysfunction in patients exposed to cardiotoxic agents. A novel technique triplane (3P) echocardiography also allows single beat assessment of LV global longitudinal strain values. We firstly aimed to demonstrate both two-dimensional (2D)- and 3PSTE-derived LV global longitudinal strain measurements in children after anthracycline exposure...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29339692/transvenous-extraction-of-a-26-year-old-accufix-atrial-lead-using-tightrail-rotating-dilator-sheath
#8
Anar Mammadli, Veysel Kutay Vurgun, Onur Yıldırım, Ali Timuçin Altın, Başar Candemir, Ömer Akyürek
With the increasing number of implanted pacemakers and implantable cardioverter defibrillators, removal is required more frequently. Presently described is the transvenous extraction of a 26-year-old Accufix atrial lead using a mechanical dilator sheath. A 50-year-old male patient was admitted to the clinic with a pacemaker pocket infection. The atrial lead was an Accufix Bipolar J-Atrial active fixation lead, a model that was recalled in 1994, after reports of 2 deaths and 2 nonfatal injuries related to protrusion of the J retention wire...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29338918/filling-pressures-in-fontan-revisited-comparison-between-pulmonary-artery-wedge-ventricular-end-diastolic-and-left-atrial-pressures-in-adults
#9
William R Miranda, Alexander C Egbe, Donald J Hagler, Nathaniel W Taggart, Rick A Nishimura, Heidi M Connolly, Carole A Warnes
BACKGROUND: Pulmonary artery wedge pressure (PAWP) has been shown to correlate better with left atrial pressure (LAP) than ventricular end-diastolic pressure (VEDP) in acquired heart disease. The correlation between VEDP and PAWP and their performance as surrogates for LAP in Fontan patients is unknown. METHODS: Offline single-beat simultaneous measurement of PAWP and VEDP was performed in 50 adult Fontan patients and non-simultaneous hemodynamic data abstracted for calculation of pulmonary vascular resistance (PVR)...
December 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29338497/a-prospective-observational-study-comparing-cardiac-function-of-small-for-gestational-age-with-appropriate-for-gestational-age-babies-using-serial-echocardiographic-studies
#10
Manish Kumar, Santhanam Sridhar, Niranjan Thomas
BACKGROUND: Approximately 30% of babies born in India are low birth weight (LBW) and about 70% of LBW babies are small for gestational age (SGA). Though there are several trials that have evaluated cardiac function of intrauterine growth restricted (IUGR) babies in utero, there is limited data about postnatal cardiac function in SGA babies during early neonatal period. This study was conducted to evaluate the cardiac functions of SGA babies by serial echocardiographic measurements and compare this with appropriate for gestational age (AGA) babies during the early postnatal period...
January 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29338024/quantitative-in-vivo-mapping-of-myocardial-mitochondrial-membrane-potential
#11
Nathaniel M Alpert, Nicolas Guehl, Leon Ptaszek, Matthieu Pelletier-Galarneau, Jeremy Ruskin, Moussa C Mansour, Dustin Wooten, Chao Ma, Kazue Takahashi, Yun Zhou, Timothy M Shoup, Marc D Normandin, Georges El Fakhri
BACKGROUND: Mitochondrial membrane potential (ΔΨm) arises from normal function of the electron transport chain. Maintenance of ΔΨm within a narrow range is essential for mitochondrial function. Methods for in vivo measurement of ΔΨm do not exist. We use 18F-labeled tetraphenylphosphonium (18F-TPP+) to measure and map the total membrane potential, ΔΨT, as the sum of ΔΨm and cellular (ΔΨc) electrical potentials. METHODS: Eight pigs, five controls and three with a scar-like injury, were studied...
2018: PloS One
https://www.readbyqxmd.com/read/29336395/tricuspid-valve-straddling-an-uncommon-cause-of-left-ventricular-outflow-tract-obstruction-in-transposition-of-great-artery-with-ventricular-septal-defect
#12
Bhupesh Kumar, Aveek Jayant, Ganesh Kumar Munirathinam, Sachin Mahajan
Transposition of great arteries (TGA) can be associated with left ventricle outflow tract (LVOT) obstruction. In the presence of ventricular septal defect (VSD), septal leaflet of tricuspid valve may prolapse through perimembranous VSD or rarely tricuspid valve tissue may override to produce LVOT obstruction. Occasionally, this may be mistaken for vegetation due to associated pulmonary valve endocarditis. We report a case of d-TGA with presumptive pulmonary valve endocarditis and LVOT obstruction that was found to be due to tricuspid valve straddling on transesophageal echocardiography, resulting in change in the surgical plan and thus avoiding catastrophe...
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29336370/differences-of-matrix-metalloproteinase-2-expression-between-left-and-right-ventricles-in-response-to-nandrolone-decanoate-and-or-swimming-training-in-mice
#13
Ying Bai, Xu-Bo Shi, Yu-Qiong Zhang, Yue-Li Wang, Xin-Yao Liu, María Asunción Esteve-Pastor
BACKGROUND: Matrix metalloproteinase (MMP)-2 plays an important role in the remodeling of left ventricles (LVs) and right ventricles (RVs). We investigated the differences of MMP-2 expression between LV and RV in response to nandrolone decanoate (ND), swimming training (ST), and combined ND and ST (NS) in mice, based on their structural, functional, and biochemical characteristics. METHODS: Totally 28 male C57B1 mice (6 weeks old; 20-23 g) were divided into four groups, including the control (n = 7), ND (n = 6), ST (n = 8), and NS (n = 7) groups...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29334828/an-unusual-combination-of-double-inlet-left-ventricle-with-discordant-ventriculoarterial-connections-and-bilateral-arterial-ducts
#14
Safak Alpat, Adrian Crucean, Tarak Desai, Simon McGuirk, Robert H Anderson, Phil Botha, David Barron
The presence of bilaterally persistent arterial ducts is an uncommon abnormality. Here, we describe the anatomy and successful management of an unusual patient with bilateral ducts in the setting of double inlet left ventricle, discordant ventriculoarterial connections, aortic atresia, and a severely hypoplastic and serpentine aortic arch.
January 1, 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29333914/hybrid-pet-mri-imaging-in-healthy-unsedated-newborn-infants-with-quantitative-rcbf-measurements-using-15o-water-pet
#15
Julie B Andersen, Ulrich Lindberg, Oline V Olesen, Didier Benoit, Claes N Ladefoged, Henrik Bw Larsson, Liselotte Højgaard, Gorm Greisen, Ian Law
In this study, a new hybrid PET/MRI method for quantitative regional cerebral blood flow (rCBF) measurements in healthy newborn infants was assessed and the low values of rCBF in white matter previously obtained by arterial spin labeling (ASL) were tested. Four healthy full-term newborn subjects were scanned in a PET/MRI scanner during natural sleep after median intravenous injection of 14 MBq 15O-water. Regional CBF was quantified using a one-tissue-compartment model employing an image-derived input function (IDIF) from the left ventricle...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29332921/early-diastolic-left-ventricular-relaxation-in-normal-neonates-is-influenced-by-ventricular-stiffness-and-longitudinal-systolic-function
#16
Yukako Homma, Yasunobu Hayabuchi, Tomomasa Terada, Miki Inoue, Kazuhiro Mori
Tissue Doppler velocity during early diastole (e') is one of the most feasible and reproducible echocardiographic assessments to reflect active relaxation of the left ventricle. Although several reports have described the mechanisms of temporal diastolic dysfunction in the early neonatal period, factors influencing diastolic function have not been determined. The purpose of this study was to elucidate factors significantly influencing e' in the early neonatal period.A total of 179 consecutive normal neonates underwent echocardiographic studies performed at 0 days and 5-10 days after birth...
January 15, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29332410/myocardial-strain-stress-changes-identified-by-echocardiography-may-reveal-early-sepsis-induced-myocardial-dysfunction
#17
Xiaoting Wang, Longxiang Su, Rongli Yang, Hongmin Zhang, Dawei Liu
Objective To perform early assessment of sepsis-induced myocardial dysfunction (SIMD) using strain/stress echocardiography. Methods A canine model of SIMD was established using intravenous injection of lipopolysaccharide (LPS, 2 mg/kg). Thirteen dogs were included, comprising an LPS-treated SIMD group ( n = 7) and saline control group ( n = 6). SIMD was assessed at various time-points using cardiac measurements including haemodynamics and echocardiography. Results Systolic and radial ventricular wall stress and circular ventricular wall stress (WSsc) were significantly lower in the sepsis group versus the control group at all time-points...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29331788/curcumin-inhibits-cardiac-hypertrophy-and-improves-cardiovascular-function-via-enhanced-na-ca2-exchanger-expression-after-transverse-abdominal-aortic-constriction-in-rats
#18
Xiao-Jie Bai, Jun-Tao Hao, Jin Wang, Wei-Fang Zhang, Cai-Ping Yan, Jia-Hui Zhao, Zhi-Qing Zhao
BACKGROUND: This study tested the hypothesis that inhibition of cardiac hypertrophy and preservation of cardiac/endothelial function by the natural yellow pigment curcumin are associated with upregulated expression of Na+/Ca2+ exchanger (NCX) after transverse aortic constriction (TAC). METHODS: Male Wistar rats were subjected to TAC for 10 weeks and curcumin (50 mg/kg/day) was fed by gastric gavage during TAC. Expression of NCX and endothelial nitric oxide synthase (eNOS) was analyzed by Western blot and immunohistochemistry...
July 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29331356/assessment-of-diastolic-function-using-ultrasound-elastography
#19
Maryam Vejdani-Jahromi, Jenna Freedman, Young-Joong Kim, Gregg E Trahey, Patrick D Wolf
Shear wave elasticity imaging (SWEI) is a novel ultrasound elastography technique for assessing tissue stiffness. In this study, we investigate the potential of SWEI for providing diastolic functional assessment. In 11 isolated rabbit hearts, pressure-volume (PV) measurements were recorded simultaneously with SWEI recordings from the left ventricle free wall before and after induction of global ischemia. PV-based end diastolic stiffness increased by 100% after ischemia (p <0.05), and SWEI stiffness showed an increase of 103% (p <0...
January 10, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29330683/cardiac-function-during-weaning-failure-the-role-of-diastolic-dysfunction
#20
Ferran Roche-Campo, Alexandre Bedet, Emmanuel Vivier, Laurent Brochard, Armand Mekontso Dessap
BACKGROUND: Cardiac dysfunction is a common cause of weaning failure. Weaning shares some similarities with a cardiac stress test and may challenge active phases of the cardiac cycle-like ventricular contractility and relaxation. This study aimed at assessing systolic and diastolic function during the weaning process and scrutinizing their dynamics during weaning trials. METHODS: Echocardiography was performed during baseline ventilator settings to assess cardiac function at the initiation of the weaning process and at the start and the end of consecutive weaning trials (performed at day-1, day-2, and before extubation if applicable) to explore the evolution of left ventricle contractility and relaxation in a subset of patients...
January 9, 2018: Annals of Intensive Care
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