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https://www.readbyqxmd.com/read/28722247/left-ventricular-function-and-regional-strain-with-subtly-tagged-steady-state-free-precession-feature-tracking
#1
Eric M Schrauben, Brett R Cowan, Andreas Greiser, Alistair A Young
PURPOSE: To provide regional strain and ventricular volume from a single acquisition, using subtly tagged steady-state free precession (SubTag SSFP) feature tracking. MATERIALS AND METHODS: The effects on regional strain of tag strength in gradient recalled echo (GRE) tagging, flip angle in untagged balanced SSFP, and both in SubTag SSFP were examined in the mid left ventricle of 15 healthy volunteers at 3T. Optimal parameters were determined from varying both tag strength and SSFP flip angle using full tag saturation GRE as the reference standard...
July 19, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28722131/kept-in-the-loop-longitudinal-strain-volume-relationships-for-the-assessment-of-left-ventricular-mechanical-performance
#2
Stephen P Wright, Robert Lakin, Denise J Wooding, Leah Groves
In health, the aortic valve facilitates unidirectional forward flow from the left ventricle (LV) to the systemic circulation. This article is protected by copyright. All rights reserved.
July 19, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28721647/rubidium-82-pet-imaging-is-feasible-in-a-rat-myocardial-infarction-model
#3
Adam Ali Ghotbi, Andreas Clemmensen, Kasper Kyhl, Bjarke Follin, Philip Hasbak, Thomas Engstrøm, Rasmus Sejersten Ripa, Andreas Kjaer
BACKGROUND: Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 ((82)Rb) in a small-animal scanner using a rat myocardial infarct model. METHODS: 18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure...
July 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28721548/left-atrium-passive-ejection-fraction-is-the-most-sensitive-index-of-type-2-diabetes-mellitus-related-cardiac-changes
#4
Yongning Shang, Xiaochun Zhang, Weiling Leng, Xiaotian Lei, Liu Chen, Ziwen Liang, Jian Wang
The aims of this study were to use cardiovascular magnetic resonance (CMR) cine to assess left atrium (LA) and left ventricle (LV) function and structure in normotensive type 2 diabetes mellitus (T2DM) patients and to identify the most sensitive index of those T2DM-related cardiac changes. Fifty T2DM patients with normotension (25 males, age 54.7 ± 8.7 years, duration of diabetes: 7.5 ± 5.1 years) and 35 controls (16 males, age: 52.2 ± 13.2 years) were prospectively enrolled. All patients were scanned using CMR four- and two-chamber long-axis cine to assess LA and LV structure and function...
July 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28720600/is-the-mechanism-of-re-expansion-pulmonary-oedema-in-a-heart-lung-interaction
#5
Candy Masego Mokotedi, Martin Balik
The mechanism of re-expansion pulmonary oedema (Re-PE) is unclear. There are multiple variables in play when evaluating the response to evacuation of pleural fluid. We present an educational case of a critically ill patient admitted for respiratory failure who was fully dependent on ventricular pacing set at a constant rate throughout the episode of Re-PE. The transthoracic echocardiography (TTE) showed an ejection fraction of 38%, moderate mitral regurgitation (MR), mildly dilated right ventricle and moderate pulmonary hypertension...
July 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28719516/echocardiography-and-passive-leg-raising-in-the-postoperative-period-a-prospective-observational-study
#6
Yasser El Hadouti, Lucía Valencia, Angel Becerra, Aurelio Rodríguez-Pérez, Jean L Vincent
BACKGROUND: Signs of hypovolaemia are frequent in the postoperative period, but not all patients need or respond to fluid administration. An increase in cardiac output (CO) after passive leg raising (PLR) has been demonstrated to be useful as a volume response predictor in non-surgical, spontaneously breathing patients. OBJECTIVE: The objective of this study was to evaluate the accuracy of transthoracic echocardiography after PLR to predict fluid responsiveness in post-surgical patients...
July 15, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28718077/early-risk-stratification-using-rubidium-82-positron-emission-tomography-in-stemi-patients
#7
Adam Ali Ghotbi, Philip Hasbak, Lars Nepper-Christensen, Jacob Lønborg, Kiril Atharovski, Thomas Christensen, Lene Holmvang, Thomas Engstrøm, Rasmus Sejersten Ripa, Andreas Kjær
BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 ((82)Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI. METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only (82)Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment...
July 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28717163/titin-mediated-thick-filament-activation-through-a-mechanosensing-mechanism-introduces-sarcomere-length-dependencies-in-mathematical-models-of-rat-trabecula-and-whole-ventricle
#8
Lorenzo Marcucci, Takumi Washio, Toshio Yanagida
Recent experimental evidence in skeletal muscle demonstrated the existence of a thick-filament mechanosensing mechanism, acting as a second regulatory system for muscle contraction, in addition to calcium-mediated thin filament regulation. These two systems cooperate to generate force, but the extent to which their interaction is relevant in physiologically contracting muscle was not yet assessed experimentally. Therefore, we included both regulatory mechanisms in a mathematical model of rat trabecula and whole ventricle...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717114/the-efficacy-of-isochronal-3d-mapping-based-ablation-of-ventricular-arrhythmia
#9
Masahito Suzuki, Junichi Nitta, Yosuke Hayashi, Kikou Lee, Keita Watanabe, Tatsuhiko Hirao, Nobutaka Kato, Yukihiro Inamura, Akira Sato, Masahiko Goya, Kenzo Hirao, Mitsuaki Isobe
Treatment of ventricular arrhythmias (VAs) commonly involves ablating sites showing electrograms with the earliest activity relative to the VA, but there is no threshold value for prematurity guaranteeing success. Ablation of sites with great prematurity can still result in failure.We hypothesized that isochronal map area (ISCA), derived from isochrones indicating electrogram prematurity, could help identify ablation targets in VA patients, as well as predict outcome. Specifically, we hypothesized that smaller ICSA for a given prematurity value would indicate a shallower arrhythmogenic focus leading to a higher likelihood of successful ablation...
July 14, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28715069/impact-of-diabetes-on-association-between-epicardial-fat-thickness-and-extent-and-complexity-of-coronary-artery-disease-in-patients-with-non-st-elevation-myocardial-infarction
#10
Taner Seker, Caner Turkoglu, Hazar Harbalıoglu, Mustafa Gur
BACKGROUND: Epicardial fat thickness (EFT) is associated with increased cardio metabolic risk. Recent studies have suggested that there is a strong relationship between diabetes and EFT. Although the relationship between EFT and coronary artery disease (CAD) is well known, the possible impact of diabetes on the relationship between EFT and extent and complexity of CAD was not fully investigated. AIM: We aimed to investigate the relationship between EFT and extent and complexity of CAD in patients with non-ST elevation myocardial infarction (NSTEMI) with and without diabetes...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28714245/drug-loaded-multifunctional-nanoparticles-targeted-to-the-endocardial-layer-of-the-injured-heart-modulate-hypertrophic-signaling
#11
Mónica P A Ferreira, Sanjeev Ranjan, Sini Kinnunen, Alexandra Correia, Virpi Talman, Ermei Mäkilä, Brianda Barrios-Lopez, Marianna Kemell, Vimalkumar Balasubramanian, Jarno Salonen, Jouni Hirvonen, Heikki Ruskoaho, Anu J Airaksinen, Hélder A Santos
Ischemic heart disease is the leading cause of death globally. Severe myocardial ischemia results in a massive loss of myocytes and acute myocardial infarction, the endocardium being the most vulnerable region. At present, current therapeutic lines only ameliorate modestly the quality of life of these patients. Here, an engineered nanocarrier is reported for targeted drug delivery into the endocardial layer of the left ventricle for cardiac repair. Biodegradable porous silicon (PSi) nanoparticles are functionalized with atrial natriuretic peptide (ANP), which is known to be expressed predominantly in the endocardium of the failing heart...
July 17, 2017: Small
https://www.readbyqxmd.com/read/28714039/current-role-of-echocardiography-in-cardiac-resynchronization-therapy
#12
REVIEW
Donato Mele, Matteo Bertini, Michele Malagù, Marianna Nardozza, Roberto Ferrari
Cardiac resynchronization therapy (CRT) is an established treatment for patients with heart failure and left ventricular systolic dysfunction. Patients are usually assessed by echocardiography, which provides a number of anatomical and functional information used for cardiac dyssynchrony assessment, prognostic stratification, identification of the optimal site of pacing in the left ventricle, optimization of the CRT device, and patient follow-up. Compared to other cardiac imaging techniques, echocardiography has the advantage to be non-invasive, repeatable, and safe, without exposure to ionizing radiation or nefrotoxic contrast...
July 17, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28712998/brain-natriuretic-peptide-mediates-the-prognostic-role-of-renal-function-towards-10-year-cardiovascular-mortality-in-patients-with-acute-coronary-syndrome-the-hhf-study-2006-2016
#13
Christina Chrysohoou, George Georgiopoulos, Hara Kosyfa, Ioanna Kotsopoulou Haritou, Matina Kouvari, Androniki Filippou, Stelios Iosifidis, Eleftherios Tsiamis, Panagiotis Aggelopoulos, Christos Pitsavos, Dimitris Tousoulis
BACKGROUND/INTRODUCTION: Risk stratification in chronic heart failure (HF) remains a challenge. Renal function and B-natriuretic peptide (BNP) might confer predictive value towards long-term mortality in HF patients after an acute coronary syndrome (ACS). METHODS: From May 2006 to March 2009, 1,000 consecutive patients who were hospitalized with ACS diagnosis were enrolled in the study. In 2016, the 10-year follow-up (2006-2016) was performed in 745 participants...
July 13, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28710467/human-ipsc-derived-cardiomyocytes-cultured-in-3d-engineered-heart-tissue-show-physiological-upstroke-velocity-and-sodium-current-density
#14
Marc D Lemoine, Ingra Mannhardt, Kaja Breckwoldt, Maksymilian Prondzynski, Frederik Flenner, Bärbel Ulmer, Marc N Hirt, Christiane Neuber, András Horváth, Benjamin Kloth, Hermann Reichenspurner, Stephan Willems, Arne Hansen, Thomas Eschenhagen, Torsten Christ
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising tool for drug testing and modelling genetic disorders. Abnormally low upstroke velocity is a current limitation. Here we investigated the use of 3D engineered heart tissue (EHT) as a culture method with greater resemblance to human heart tissue in comparison to standard technique of 2D monolayer (ML) format. INa was measured in ML or EHT using the standard patch-clamp technique. INa density was ~1.8 fold larger in EHT (-18...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709664/current-results-of-single-ventricle-palliation-of-patients-with-double-inlet-left-ventricle
#15
Bahaaldin Alsoufi, Courtney McCracken, Kirk Kanter, Subhadra Shashidharan, Brian Kogon
BACKGROUND: Double inlet left ventricle (DILV) is a heterogeneous single ventricle anomaly in which initial presentation, and consequently, timing and palliation mode vary based on morphology and degree of pulmonary or systemic outflow obstruction. Very few reports, mostly old, focused on palliation outcomes of DILV. We report current-era results and examine whether morphologic and subsequently surgical factors influence survival. METHODS: Fifty-eight infants with DILV underwent single ventricle palliation...
July 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28709661/left-sided-reoperations-after-arterial-switch-operation-a-european-multicenter-study
#16
Vladimiro L Vida, Lorenza Zanotto, Lucia Zanotto, Giovanni Stellin, Massimo Padalino, Georges Sarris, Eleftherios Protopapas, Carol Prospero, Christian Pizarro, Edward Woodford, Thomas Tlaskal, Hakan Berggren, Martin Kostolny, Ikenna Omeje, Boulos Asfour, Alexander Kadner, Thierry Carrel, Paul H Schoof, Matej Nosal, Josè Fragata, Michał Kozłowski, Bohdan Maruszewski, Luca A Vricella, Duke E Cameron, Vladimir Sojak, Mark Hazekamp, Jukka Salminen, Ilkka P Mattila, Julie Cleuziou, Patrick O Myers, Viktor Hraska
BACKGROUND: We sought to report the frequency, types, and outcomes of left-sided reoperations (LSRs) after an arterial switch operation (ASO) for patients with D-transposition of the great arteries (D-TGA) and double-outlet right ventricle (DORV) TGA-type. METHODS: Seventeen centers belonging to the European Congenital Heart Surgeons Association (ECHSA) contributed to data collection. We included 111 patients who underwent LSRs after 7,951 ASOs (1.4%) between January 1975 and December 2010...
July 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28708556/deep-learning-on-sparse-manifolds-for-faster-object-segmentation
#17
Jacinto C Nascimento, Gustavo Carneiro
We propose a new combination of deep belief networks and sparse manifold learning strategies for the 2D segmentation of non-rigid visual objects. With this novel combination, we aim to reduce the training and inference complexities while maintaining the accuracy of machine learning based non-rigid segmentation methodologies. Typical non-rigid object segmentation methodologies divide the problem into a rigid detection followed by a non-rigid segmentation, where the low dimensionality of the rigid detection allows for a robust training (i...
July 11, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28708196/assessment-of-mitral-apparatus-in-patients-with-acute-inferoposterior-myocardial-infarction-and-ischaemic-mitral-regurgitation-with-two-dimensional-echocardiography-from-anatomically-correct-imaging-planes
#18
Karolina Mėlinytė, Živile Valuckiene, Renaldas Jurkevičius
BACKGROUND: Ischaemic mitral regurgitation (IMR) is associated with adverse prognosis after myocardial infarction (MI) as a result of left ventricular remodelling and geometric deformation of the mitral apparatus (MA). AIM: The aim of this study was to assess MA from anatomically correct imaging planes in acute inferoposterior MI and IMR. METHODS: Ninety-three patients with no structural cardiac valve abnormalities and the first acute inferoposterior MI were prospectively enrolled into the study...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28706592/inadvertent-cardiac-phlebography
#19
Konstantinos Aznaouridis, Constantina Masoura, Stylianos Kastellanos, Albert Alahmar
We are reporting a case of a 80-year-old lady with effort angina who underwent coronary angiography through the right radial artery, using a dedicated radial multipurpose 5 French Optitorque Tiger catheter. The catheter was advanced into the left ventricle and a left ventriculogram was obtained, while the catheter appeared optimally placed at the centre of the ventricle and the pressure waveform was normal. A large posterior interventricular vein draining into the right atrium was opacified, presumably because the catheter's end hole inadvertently cannulated an endocardial opening of a small thebesian vein, with subsequent retrograde filling of the epicardial vein...
June 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28706583/cardiac-damage-in-athlete-s-heart-when-the-supernormal-heart-fails
#20
REVIEW
Andreina Carbone, Antonello D'Andrea, Lucia Riegler, Raffaella Scarafile, Enrica Pezzullo, Francesca Martone, Raffaella America, Biagio Liccardo, Maurizio Galderisi, Eduardo Bossone, Raffaele Calabrò
Intense exercise may cause heart remodeling to compensate increases in blood pressure or volume by increasing muscle mass. Cardiac changes do not involve only the left ventricle, but all heart chambers. Physiological cardiac modeling in athletes is associated with normal or enhanced cardiac function, but recent studies have documented decrements in left ventricular function during intense exercise and the release of cardiac markers of necrosis in athlete's blood of uncertain significance. Furthermore, cardiac remodeling may predispose athletes to heart disease and result in electrical remodeling, responsible for arrhythmias...
June 26, 2017: World Journal of Cardiology
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