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https://www.readbyqxmd.com/read/28453807/attrition-in-patients-with-single-ventricle-and-trisomy-21-outcomes-after-a-total-cavopulmonary-connection
#1
Anastasios C Polimenakos, Sujata Subramanian, Chawki ElZein, Michel N Ilbawi
OBJECTIVES: Data are limited regarding the management of children with trisomy 21 (T21) syndrome and a functional single ventricle (FSV). We evaluated patients with T21 and a FSV who had a total cavopulmonary connection (TCPC). METHODS: From September 1999 to August 2012, 139 patients with a FSV underwent a TCPC. Sixty-five had unbalanced atrioventricular septal defect. Thirteen had T21. Three (of 13) had heterotaxy syndrome. The mean age at the Fontan operation was 27...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28449514/left-ventricular-outflow-tract-obstruction-due-to-a-left-ventricular-myxoma-that-was-misidentified-as-an-accessory-mitral-valve-tissue
#2
Seung-Hoon Baek, Hee Young Kim, Hyae Jin Kim, Sang Wook Shin, Hye Jin Kim, Yun Mi Choi, Eun Ji Choi, Eunjung Chang, Hong-Sik Son
We report obstruction of the left ventricle outflow tract (LVOT) caused by cardiac myxoma that was misidentified as an accessory mitral valve tissue preoperatively. A 65-year-old woman presented with chest discomfort that persisted for 7 days. Transthoracic echocardiography (TTE) revealed a mobile, low-echogenic, balloon-shaped mass attached to the anterior mitral valve leaflet and papillary muscle, which was suspected to be an accessory mitral valve tissue. Because the mass caused LVOT obstruction and it could result in hemodynamic instability, emergency operation was performed...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448522/nestin-expression-is-upregulated-in-the-fibrotic-rat-heart-and-is-localized-in-collagen-expressing-mesenchymal-cells-and-interstitial-cd31-cells
#3
Vanessa Hertig, Kim Tardif, Marc Andre Meus, Natacha Duquette, Louis Villeneuve, Fanny Toussaint, Jonathan Ledoux, Angelino Calderone
Renal and lung fibrosis was characterized by the accumulation of collagen-immunoreactive mesenchymal cells expressing the intermediate filament protein nestin. The present study tested the hypothesis that nestin expression was increased in the hypertrophied/fibrotic left ventricle of suprarenal abdominal aorta constricted adult male Sprague-Dawley rats and induced in ventricular fibroblasts by pro-fibrotic peptide growth factors. Nestin protein levels were upregulated in the pressure-overloaded left ventricle and expression positively correlated with the rise of mean arterial pressure...
2017: PloS One
https://www.readbyqxmd.com/read/28445763/myosin-rod-hypophosphorylation-and-cb-kinetics-in-papillary-muscles-from-a-tnc-a8v-ki-mouse-model
#4
Masataka Kawai, Jamie R Johnston, Tarek Karam, Li Wang, Rakesh K Singh, Jose R Pinto
The cardiac troponin C (TnC)-A8V mutation is associated with hypertrophic and restrictive cardiomyopathy (HCM and RCM) in human and mice. The residue affected lies in the N-helix, a region known to affect Ca(2+)-binding affinity to the N-terminal domain. Here we report on the functional effects of this mutation in skinned papillary muscle fibers from homozygous knock-in TnC-A8V mice. Muscle fibers from left ventricle were activated at 25°C under the ionic conditions of working cardiomyocytes. The pCa-tension relationship showed a 3× increase in Ca(2+)-sensitivity and a decrease (0...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445281/relationship-between-the-abnormal-diastolic-vortex-structure-and-impaired-left-ventricle-filling-in-patients-with-hyperthyroidism
#5
Bin-Yu Zhou, Ming-Xing Xie, Jing Wang, Xin-Fang Wang, Qing Lv, Man-Wei Liu, Shuang-Shuang Kong, Ping-Yu Zhang, Jin-Feng Liu
Intraventricular hydrodynamics plays an important role in evaluating cardiac function. Relationship between diastolic vortex and left ventricular (LV) filling is still rarely elucidated. The aim of this study was to evaluate the evolution of vortex during diastole in hyperthyroidism (HT) and explore the alteration of hydromechanics characteristics with sensitive indexes.Forty-three patients diagnosed with HT were classified into 2 groups according to whether myocardial damage existed: simple hyperthyroid group (HT1, n = 21) and thyrotoxic cardiomyopathy (HT2, n = 22)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444887/morphological-study-of-the-atrioventricular-conduction-system-and-purkinje-fibers-in-yak
#6
Deyong Duan, Sijiu Yu, Yan Cui, Chaoxu Li
We studied the morphology of the atrioventricular conduction system (AVCS) and Purkinje fibers of the yak. Light and transmission electron microscopy were used to study the histological features of AVCS. The distributional characteristics of the His-bundle, the left bundle branch (LBB), right bundle branch (RBB), and Purkinje fiber network of yak hearts were examined using gross dissection, ink injection, and ABS casting. The results showed that the atrioventricular node (AVN) of yak located in the right side of interatrial septum and had a flattened ovoid shape...
April 26, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28444503/comparative-evaluation-of-the-algorithms-for-parametric-mapping-of-the-novel-myocardial-pet-imaging-agent-18-f-fptp
#7
Ji Who Kim, Seongho Seo, Hyeon Sik Kim, Dong-Yeon Kim, Ho-Young Lee, Keon Wook Kang, Dong Soo Lee, Hee-Seung Bom, Jung-Joon Min, Jae Sung Lee
OBJECTIVE: ((18)F-fluoropentyl)triphenylphosphonium salt ((18)F-FPTP) is a new promising myocardial PET imaging tracer. It shows high accumulation in cardiomyocytes and rapid clearance from liver. We performed compartmental analysis of (18)F-FPTP PET images in rat and evaluated two linear analyses: linear least-squares (LLS) and a basis function method (BFM) for generating parametric images. The minimum dynamic scan duration for kinetic analysis was also investigated and computer simulation undertaken...
April 25, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28444210/initial-shunt-type-at-the-norwood-operation-impacts-myocardial-function-in-hypoplastic-left-heart-syndrome%C3%A2
#8
Hanna K Ruotsalainen, Jaana Pihkala, Jukka Salminen, Lisa K Hornberger, Heikki Sairanen, Tiina Ojala
OBJECTIVES: We investigated the impact of initial shunt type, a Blalock-Taussig (BT) shunt versus a right ventricle to pulmonary artery conduit (RV-PA) on myocardial function at different stages of surgical palliation in patients with hypoplastic left heart syndrome (HLHS). METHODS: A population-based cohort of 63 Finnish children with HLHS (BT n  = 23, RV-PA n  = 40) born between 2003 and 2010 were studied retrospectively by echocardiography prior to Stages 1, 2 and 3 palliation and 0...
April 24, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28444164/vena-contracta-area-for-severity-grading-in-functional-and-degenerative-mitral-regurgitation-a-transoesophageal-3d-colour-doppler-analysis-in-500-patients
#9
Björn Goebel, Roland Heck, Ali Hamadanchi, Sylvia Otto, Torsten Doenst, Christian Jung, Alexander Lauten, Hans R Figulla, P Christian Schulze, Tudor C Poerner
Aims: Vena contracta area (VCA3D), derived by 3D colour Doppler echocardiography, has already been validated against cardiac magnetic resonance imaging, but the number of clinical studies to define cut-off values for grading of mitral regurgitation (MR) is limited. Aim of the study was to assess VCA3D in a large population of patients with functional (FMR) and degenerative MR (DMR). Methods and results: Transoesophageal echocardiography was performed in 500 patients with MR...
April 21, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28444133/increased-collagen-within-the-transverse-tubules-in-human-heart-failure
#10
David J Crossman, Xin Shen, Mia Jüllig, Michelle Munro, Yufeng Hou, Martin Middleditch, Darshan Shrestha, Amy Li, Sean Lal, Cristobal G Dos Remedios, David Baddeley, Peter N Ruygrok, Christian Soeller
Aims: In heart failure transverse-tubule (t-tubule) remodelling disrupts calcium release, and contraction. T-tubules in human failing hearts exhibit increased labelling by wheat germ agglutinin (WGA), a lectin that binds to the dystrophin-associated glycoprotein complex. We hypothesized changes in this complex may explain the increased WGA labelling and contribute to t-tubule remodelling in the failing human heart. In this study we sought to identify the molecules responsible for this increased WGA labelling...
April 20, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28442964/-graded-epidural-anesthesia-for-renal-transplant-in-a-patient-with-dilated-cardiomyopathy-and-severe-left-ventricle-systolic-dysfunction
#11
Rupesh Yadav, Sohan Lal Solanki
Dilated cardiomyopathy with decreased contractility of left or both ventricles impose a serious risk to patient posted for major surgery. Even after best medical optimization, careful perioperative management with risk and benefit of general and regional anesthesia should be discussed beforehand. We here reporting a case of successful management of a patient with dilated cardiomyopathy with ejection fraction of 15% posted for renal transplant surgery under graded epidural anesthesia.
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28442846/gunshot-pellet-migration-to-the-right-ventricle-a-case-report-and-literature-review
#12
Wu Jiachang, Zhao Haien, Luo Yuanguo, Wang Lei, Lin Zhoudan, Yang Hua
The diagnosis and management of injuries of the heart or the great vessels continues to be a major surgical challenge in the past and now. This case study introduces the conservative management of a patient who developed a venous bullet embolus after being shot in the lower extremities. In this case report, we aim to review some of the literature on bullet emboli and to raise awareness of its existence. It was concluded that for bullets left in the limbs, bullet position in relation with peripheral vessels should be evaluated carefully to treat and avoid the bullets moving along with the bloodstream...
April 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28442147/troubleshooter-in-electrical-storm-mechanical-unloading-leads-to-heart-rhythm-stabilization
#13
Johannes Mierke, Tobias Loehn, Christian Pfluecke, Karim Ibrahim
The electrical storm is a life-threatening situation which causes a complex antiarrhythmic treatment. We firstly report a rhythmological stabilization through mechanical unloading of the left ventricle in a health patient who developed electrical storm after endo- and epicardiac re-ablation and who previously underwent 27 unsuccessful defibrillations. No evidence for a specific etiology of the rhythm disturbances was found. After implantation of a percutaneous left ventricular assist device (pLVAD) a single additional defibrillation was needed to terminate ventricular fibrillation...
April 18, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28439937/maternal-nutrient-restriction-during-pregnancy-and-lactation-leads-to-impaired-right-ventricular-function-in-young-adult-baboons
#14
Anderson H Kuo, Cun Li, Hillary F Huber, Matthias Schwab, Peter W Nathanielsz, Geoffrey D Clarke
Maternal nutrient restriction induces IUGR increasing later life chronic disease including cardiovascular dysfunction. Our left ventricular (LV) CMRI studies in IUGR baboons (8 M, 8 F, 5.7 years- human equivalent approximately 25 years), control offspring (8 M, 8 F, 5.6 years), and normal elderly (OLD) baboons (6 M, 6 F, mean 15.9 years) revealed long-term LV abnormalities in IUGR offspring. Although it is known that right ventricular (RV) function is dependent on LV health, the IUGR right ventricle (RV) remains poorly studied...
April 25, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28439736/early-cardiac-perfusion-defects-after-left-sided-radiation-therapy-for-breast-cancer-is-there-a-volume-response
#15
REVIEW
Orit Kaidar-Person, Timothy M Zagar, Jorge Daniel Oldan, Jason Matney, Ellen L Jones, Shiva Das, Brian C Jensen, Richard C Zellars, Terence Z Wong, Lawrence B Marks
PURPOSE: Cardiac single-photon emission computed tomography (SPECT) is often used to identify defects in myocardial perfusion due to atherosclerotic coronary artery disease. It was also used in studies to evaluate radiation therapy (RT)-associated cardiac abnormalities. In the current review, we aim to evaluate the rates of post-RT cardiac SPECT early perfusion abnormalities and relate this to the irradiated left ventricular volume. METHODS: The studies cited in this systematic review were identified using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines...
April 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28439652/myocardial-extracellular-volume-fraction-quantified-by-cardiovascular-magnetic-resonance-is-increased-in-hypertension-and-associated-with-left-ventricular-remodeling
#16
Shuli Wang, Hongjie Hu, Minjie Lu, Arlene Sirajuddin, Jinghui Li, Jing An, Xiuyu Chen, Gang Yin, Tian Lan, Linlin Dai, Yan Zhang, Xiaorong Yin, Lei Song, Aimin Dang, Peter Kellman, Andrew E Arai, Shihua Zhao
OBJECTIVES: To determine whether extracellular volume fraction (ECV) quantification by cardiac magnetic resonance (CMR) can demonstrate left ventricle (LV) abnormalities and relationship between ECV and LV remodeling in hypertension (HTN) patients METHODS: ECV quantification was prospectively performed in 134 consecutive HTN patients and 97 healthy subjects. Individual and regional ECV were compared to the regions on late gadolinium enhancement (LGE) images. Statistical analysis of the relationship between LV global functional parameters and ECV was carried out using Pearson's correlation, Student's t test and multiple regressions...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28437634/convolutional-neural-network-regression-for-short-axis-left-ventricle-segmentation-in-cardiac-cine-mr-sequences
#17
Li Kuo Tan, Yih Miin Liew, Einly Lim, Robert A McLaughlin
Automated left ventricular (LV) segmentation is crucial for efficient quantification of cardiac function and morphology to aid subsequent management of cardiac pathologies. In this paper, we parameterize the complete (all short axis slices and phases) LV segmentation task in terms of the radial distances between the LV centerpoint and the endo- and epicardial contours in polar space. We then utilize convolutional neural network regression to infer these parameters. Utilizing parameter regression, as opposed to conventional pixel classification, allows the network to inherently reflect domain-specific physical constraints...
April 12, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28437575/the-24-segment-sphericity-index-a-new-technique-to-evaluate-fetal-cardiac-diastolic-shape
#18
Greggory R DeVore, Berthold Klas, Gary Satou, Mark Sklansky
INTRODUCTION: Because of parallel circulation in the fetus and the differential effect various disease states may have on the shape of the right and left ventricles, this study was conducted to evaluate the Sphericity Index (SI) of 24 transverse segments distributed from the base to the apex of the ventricular chambers. METHODS: Two hundred control fetuses were examined between 20 and 40 weeks of gestation. The displacement of the ventricular endocardium during the cardiac cycle was computed using offline software...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28436171/sex-and-regional-differences-in-rabbit-right-ventricular-l-type-calcium-current-levels-and-mathematical-modeling-of-arrhythmia-vulnerability
#19
Zane M Kalik, Joshua L Mike, Cassandra Slipski, Moriah Wright, Jozsi Z Jalics, Mark D Womble
Previous studies have shown that adult rabbit left ventricular myocytes exhibit sex and regional differences in L-type calcium current (ICa-L ) levels that contribute to increased susceptibility to arrhythmogenic early afterdepolarizations (EADs). We used patch clamp recordings from isolated adult male and female rabbit right ventricular myocytes to determine apex-base differences in ICa-L density, and mathematical modeling to examine ICa-L contribution to EAD formation. Current density measured at 0 mV in female base myocytes was 67% higher than male base myocytes and 55% higher than female apex myocytes...
April 24, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28435004/improvements-in-left-ventricular-diastolic-mechanics-after-parachute-device-implantation-in-patients-with-ischemia-heart-failure-a-cardiac-ct-study
#20
Chun-Ho Yun, Jing-Yi Sun, Barry Templin, Shih-Hsuan Lin, Kuan-Ming Chen, Tung-Hsin Wu, Chung-Lieh Hung, Chun-Chieh Liu, Hsi-Hsien Hsu, Mohamad Amer Alaiti, Anas Fares, Anthony DeCicco, Hiram G Bezerra
BACKGROUND: Percutaneous ventricular restoration therapy using left ventricle (LV) partitioning Parachute device has emerged as a clinical treatment option for LV apical aneurysm post extensive anterior myocardial infarction (AMI). We assessed changes of diastolic mechanics and accompanied functional improvements following LV parachute device implantation by cardiac computed tomography (CCT). METHODS AND RESULTS: CCT data from 28 patients in the pre- and post-implantation of LV parachute device implantation...
April 20, 2017: Journal of Cardiac Failure
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