keyword
MENU ▼
Read by QxMD icon Read
search

Protein kinase C epsilon

keyword
https://www.readbyqxmd.com/read/27793751/phospholipase-d1-modulates-protein-kinase-c-epsilon-in-retinal-pigment-epithelium-cells-during-inflammatory-response
#1
Paula E Tenconi, Norma M Giusto, Gabriela A Salvador, Melina V Mateos
Inflammation is a key factor in the pathogenesis of several retinal diseases. In view of the essential role of the retinal pigment epithelium in visual function, elucidating the molecular mechanisms elicited by inflammation in this tissue could provide new insights for the treatment of retinal diseases. The aim of the present work was to study protein kinase C signaling and its modulation by phospholipases D in ARPE-19 cells exposed to lipopolysaccharide. This bacterial endotoxin induced protein kinase C-α/βII phosphorylation and protein kinase-ε translocation to the plasma membrane in ARPE-19 cells...
October 25, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27784673/silencing-c-myc-translation-as-a-therapeutic-strategy-through-targeting-pi3k-delta-and-ck1-epsilon-in-hematological-malignancies
#2
Changchun Deng, Mark R Lipstein, Luigi Scotto, Xavier O Jirau Serrano, Michael A Mangone, Shirong Li, Jeremie Vendome, Yun Hao, Xiaoming Xu, Shi-Xian Deng, Ronald B Realubit, Nicholas P Tatonetti, Charles Karan, Suzanne Lentzsch, David A Fruman, Barry Honig, Donald W Landry, Owen A O'Connor
Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating the mechanistic target of rapamycin (mTOR). Because mTOR signaling is required for initiation of mRNA translation, we hypothesized that co-targeting the PI3K and proteasome pathways might synergistically inhibit translation of c-Myc. We found that a novel PI3K delta isoform inhibitor TGR-1202, but not the approved PI3Kδ inhibitor idelalisib, was highly synergistic with the proteasome inhibitor carfilzomib in lymphoma, leukemia, and myeloma cell lines and primary lymphoma and leukemia cells...
October 26, 2016: Blood
https://www.readbyqxmd.com/read/27771708/morphine-postconditioning-protects-against-reperfusion-injury-the-role-of-protein-kinase-c-epsilon-extracellular-signal-regulated-kinase-1-2-and-mitochondrial-permeability-transition-pores
#3
Zuolei Chen, Donat R Spahn, Xuewei Zhang, Yingzhi Liu, Haichen Chu, Zhongkai Liu
BACKGROUND/AIMS: The purpose of this study was to investigate the implications of protein kinase C-epsilon (PKCε), Extracellular Signal-regulated Kinase 1/2 (ERK1/2) and mitochondrial permeability transition pore (mPTP) in myocardial protection induced by morphine postconditioning (MpostC). METHODS: The isolated rat hearts were randomly assigned into one of eight groups. Hearts in time control (TC) group were constantly perfused for 105min. Hearts in ischemia-reperfusion (I/R) group were subjected to 45 min of ischemia followed by 1 h of reperfusion...
October 24, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27737678/effect-of-helium-pre-or-postconditioning-on-signal-transduction-kinases-in-patients-undergoing-coronary-artery-bypass-graft-surgery
#4
Kirsten F Smit, Daniel Brevoord, Stefan De Hert, Bas A de Mol, Raphaela P Kerindongo, Susan van Dieren, Wolfgang S Schlack, Markus W Hollmann, Nina C Weber, Benedikt Preckel
BACKGROUND: The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that helium induces pre- and postconditioning in CABG-patients, affecting signaling molecules protein kinase C-epsilon (PKC-ε), p38 mitogen activated protein kinase (p38 MAPK), extracellular signal-regulated kinase 1/2 (ERK-1/2) and heat shock protein 27 (HSP-27) within cardiac tissue, and reducing postoperative troponin levels...
October 14, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27717316/a-rare-c-183_187dupctcac-mutation-of-the-acetylcholine-receptor-chrne-gene-in-a-south-asian-female-with-congenital-myasthenic-syndrome-a-case-report
#5
Thashi Chang, Judith Cossins, David Beeson
BACKGROUND: Congenital myasthenic syndromes (CMSs) occur as a result of genetic mutations that cause aberrations in structure and/or function of proteins involved in neuromuscular transmission. Acetylcholine receptor epsilon (ε) subunit (CHRNE) gene mutations account for about 30-50 % of genetically diagnosed cases. We report a rare CHRNE gene mutation in a South Asian female with CMS. CASE PRESENTATION: A 17-year-old Maldivian female presented with bilateral partial ptosis, fatigable proximal muscle weakness and slurring of speech noted since the age of 2 years...
October 7, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27648441/diazoxide-attenuates-postresuscitation-brain-injury-in-a-rat-model-of-asphyxial-cardiac-arrest-by-opening-mitochondrial-atp-sensitive-potassium-channels
#6
Haidong Wu, Peng Wang, Yi Li, Manhui Wu, Jiali Lin, Zitong Huang
Objective. We investigated whether and how diazoxide can attenuate brain injury after cardiopulmonary resuscitation (CPR) by selective opening of mitochondrial ATP-sensitive potassium (mitoKATP) channels. Methods. Adult male Sprague-Dawley rats with induced cerebral ischemia (n = 10 per group) received an intraperitoneal injection of 0.1% dimethyl sulfoxide (1 mL; vehicle group), diazoxide (10 mg/kg; DZ group), or diazoxide (10 mg/kg) plus 5-hydroxydecanoate (5 mg/kg; DZ + 5-HD group) 30 min after CPR...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27643942/cardiac-connexin-43-and-pkc-signaling-in-rats-with-altered-thyroid-status-without-and-with-omega-3-fatty-acids-intake
#7
B Szeiffová Bačová, T Egan Beňová, C Viczenczová, T Soukup, H Rauchová, S Pavelka, V Knezl, M Barančík, N Tribulová
Thyroid hormones are powerful modulators of heart function and susceptibility to arrhythmias via both genomic and non-genomic actions. We aimed to explore expression of electrical coupling protein connexin-43 (Cx43) in the heart of rats with altered thyroid status and impact of omega-3 polyunsaturated fatty acids (omega-3) supplementation. Adult male Lewis rats were divided into following six groups: euthyroid controls, hyperthyroid (treated with T(3)) and hypothyroid (treated with methimazol) with or without six-weeks lasting supplementation with omega-3 (20 mg/100 g/day)...
September 19, 2016: Physiological Research
https://www.readbyqxmd.com/read/27622505/the-matrix-protein-of-nipah-virus-targets-the-e3-ubiquitin-ligase-trim6-to-inhibit-the-ikk%C3%AE%C2%B5-kinase-mediated-type-i-ifn-antiviral-response
#8
Preeti Bharaj, Yao E Wang, Brian E Dawes, Tatyana E Yun, Arnold Park, Benjamin Yen, Christopher F Basler, Alexander N Freiberg, Benhur Lee, Ricardo Rajsbaum
For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system. Nipah virus (NiV), a highly pathogenic member of the Paramyxoviridae family (genus Henipavirus), is known to encode for four P gene-derived viral proteins (P/C/W/V) with IFN-I antagonist functions. Here we report that NiV matrix protein (NiV-M), which is important for virus assembly and budding, can also inhibit IFN-I responses. IFN-I production requires activation of multiple signaling components including the IκB kinase epsilon (IKKε)...
September 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27586455/activating-mu-opioid-receptors-in-the-spinal-cord-mediates-the-cardioprotective-effect-of-remote-preconditioning-of-trauma
#9
Bin Mei, Wanhong Li, Xinqi Cheng, Xuesheng Liu, Erwei Gu, Ye Zhang
BACKGROUND: Remote precoditioning of trauma (RPCT) confers cardioprotective effects against myocardial ischemia/reperfusion injury, which are mediated by spinal opioid receptors. The aim of this study was to identify the roles of opioid receptor subtypes in the cardioprotective effect of RPCT and possible mechanisms. METHODS: In this study, 192 Sprague-Dawley rats were allocated to 12 groups. Except for the sham group, rats in all groups were subjected to myocardial ischemia reperfusion...
September 2, 2016: Cardiology Journal
https://www.readbyqxmd.com/read/27573736/pkc%C3%AE%C2%B5-mediates-resistin-induced-nadph-oxidase-activation-and-inflammation-leading-to-smooth-muscle-cell-dysfunction-and-intimal-hyperplasia
#10
Gayatri Raghuraman, Mary C Zuniga, Hai Yuan, Wei Zhou
BACKGROUND AND AIMS: Resistin has been implicated in cardiovascular disease and poor interventional cardiovascular outcomes. Previous studies by our group demonstrated resistin promoted vascular smooth muscle cell (VSMC) migration through protein kinase C epsilon (PKCε) pathways, while few others showed that resistin induced reactive oxygen species (ROS) generation in various cell types. In this study, we aim to systemically examine the functional role of resistin at the cellular and tissue levels as well as the potential mechanistic relationship between resistin-induced PKCε activation and ROS production...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27546836/protein-kinase-c%C3%A9-activity-regulates-mglur5-surface-expression-in-the-rat-nucleus-accumbens
#11
Marek Schwendt, M Foster Olive
Type 5 metabotropic glutamate receptors (mGluR5) activate protein kinase C (PKC) via coupling to Gαq/11 protein signaling. We have previously demonstrated that the epsilon isoform of PKC (PKCɛ) is a critical downstream target of mGluR5 in regulating behavioral and biochemical responses to alcohol. Recent evidence suggests that PKC-mediated phosphorylation of mGluR5 can lead to receptor desensitization and internalization. We therefore sought to examine the specific involvement of PKCɛ in the regulation of mGluR5 surface expression in the nucleus accumbens (NAc), a key regulator of alcohol-associated behaviors...
August 21, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27499186/marked-sexual-dimorphism-in-the-role-of-the-ryanodine-receptor-in-a-model-of-pain-chronification-in-the-rat
#12
Luiz F Ferrari, Eugen V Khomula, Dionéia Araldi, Jon D Levine
Hyperalgesic priming, an estrogen dependent model of the transition to chronic pain, produced by agonists at receptors that activate protein kinase C epsilon (PKCε), occurs in male but not in female rats. However, activation of second messengers downstream of PKCε, such as the ryanodine receptor, induces priming in both sexes. Since estrogen regulates intracellular calcium, we investigated the interaction between estrogen and ryanodine in the susceptibility to develop priming in females. The lowest dose of ryanodine able to induce priming in females (1 pg) is 1/100,000(th) that needed in males (100 ng), an effect dependent on the activation of ryanodine receptors...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27461137/the-role-of-epsilon-pkc-in-acute-and-chronic-diseases-possible-pharmacological-implications-of-its-modulators
#13
REVIEW
Barbara Capuani, Francesca Pacifici, Donatella Pastore, Raffaele Palmirotta, Giulia Donadel, Roberto Arriga, Alfonso Bellia, Nicola Di Daniele, Paola Rogliani, Pasquale Abete, Paolo Sbraccia, Fiorella Guadagni, Davide Lauro, David Della-Morte
Epsilon Protein kinase C (εPCK) is a particular kinase that, when activated, is able to protect against different stress injuries and therefore has been proposed to be a potential molecular target against acute and chronic diseases. Particular attention has been focused on εPCK for its involvement in the protective mechanism of Ischemic Preconditioning (IPC), a powerful endogenous mechanism characterized by subthreshold ischemic insults able to protect organs against ischemic injury. Therefore, in the past decades several εPCK modulators have been tested with the object to emulate εPCK mediate protection...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27435822/protein-kinase-c-epsilon-promotes-cerebral-ischemic-tolerance-via-modulation-of-mitochondrial-sirt5
#14
Kahlilia C Morris-Blanco, Kunjan R Dave, Isabel Saul, Kevin B Koronowski, Holly M Stradecki, Miguel A Perez-Pinzon
Sirtuin 5 (SIRT5) is a mitochondrial-localized NAD(+)-dependent lysine desuccinylase and a major regulator of the mitochondrial succinylome. We wanted to determine whether SIRT5 is activated by protein kinase C epsilon (PKCε)-mediated increases in mitochondrial Nampt and whether SIRT5 regulates mitochondrial bioenergetics and neuroprotection against cerebral ischemia. In isolated mitochondria from rat cortical cultures, PKCε activation increased SIRT5 levels and desuccinylation activity in a Nampt-dependent manner...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27330081/protein-kinase-c%C3%AF%C2%B5-pkc%C3%AF%C2%B5-promotes-synaptogenesis-through-membrane-accumulation-of-the-postsynaptic-density-protein-psd-95
#15
Abhik Sen, Jarin Hongpaisan, Desheng Wang, Thomas J Nelson, Daniel L Alkon
Protein kinase Cϵ (PKCϵ) promotes synaptic maturation and synaptogenesis via activation of synaptic growth factors such as BDNF, NGF, and IGF. However, many of the detailed mechanisms by which PKCϵ induces synaptogenesis are not fully understood. Accumulation of PSD-95 to the postsynaptic density (PSD) is known to lead to synaptic maturation and strengthening of excitatory synapses. Here we investigated the relationship between PKCϵ and PSD-95. We show that the PKCϵ activators dicyclopropanated linoleic acid methyl ester and bryostatin 1 induce phosphorylation of PSD-95 at the serine 295 residue, increase the levels of PSD-95, and enhance its membrane localization...
August 5, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27325692/xbp1s-is-an-anti-lipogenic-protein
#16
Hilde Herrema, Yingjiang Zhou, Dongyan Zhang, Justin Lee, Mario Andres Salazar Hernandez, Gerald I Shulman, Umut Ozcan
Endoplasmic reticulum (ER) stress has been shown to contribute to various metabolic diseases, including non-alcoholic fatty liver disease and type 2 diabetes. Reduction of ER stress by treatment with chemical chaperones or overexpression of ER chaperone proteins alleviates hepatic steatosis. Nonetheless, X-box binding protein 1s (XBP1s), a key transcription factor that reduces ER stress, has been proposed as a lipogenic transcription factor. In this report, we document that XBP1s leads to suppression of lipogenic gene expression and reduction of hepatic triglyceride and diacylglycerol content in livers of diet-induced obese and genetically obese and insulin-resistant ob/ob mice...
August 12, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27312950/prkce-gene-encoding-protein-kinase-c-epsilon-dual-roles-at-sarcomeres-and-mitochondria-in-cardiomyocytes
#17
REVIEW
Sarah B Scruggs, Ding Wang, Peipei Ping
Protein kinase C-epsilon (PKCε) is an isoform of a large PKC family of enzymes that has a variety of functions in different cell types. Here we discuss two major roles of PKCε in cardiac muscle cells; specifically, its role in regulating cardiac muscle contraction via targeting the sarcomeric proteins, as well as modulating cardiac cell energy production and metabolism by targeting cardiac mitochondria. The importance of PKCε action is described within the context of intracellular localization, as substrate selectivity and specificity is achieved through spatiotemporal targeting of PKCε...
September 15, 2016: Gene
https://www.readbyqxmd.com/read/27127881/risk-prediction-for-early-onset-gastric-carcinoma-a-case-control-study-of-polygenic-gastric-cancer-in-han-chinese-with-hereditary-background
#18
Jiajia Yuan, Yanyan Li, Tiantian Tian, Na Li, Yan Zhu, Jianling Zou, Jing Gao, Lin Shen
Recent genomewide studies have identified several germline variations associated with gastric cancer. The aim of the present study was to identify, in a Chinese Han population, the individual and combined effects of those single nucleotide polymorphisms (SNPs) that increase the risk of early-onset gastric cancer. We conducted a case-control study comprising 116 patients with gastric cancer as well as 102 sex- and age-matched controls and confirmed that the SNPs MUC1 (mucin 1) rs9841504 and ZBTB20 (zinc finger and BTB domain containing 20) rs4072037 were associated with an increased gastric cancer risk...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27037060/pkc%C3%AE%C2%B5-inhibits-isolation-and-stemness-of-side-population-cells-via-the-suppression-of-abcb1-transporter-and-pi3k-akt-mapk-erk-signaling-in-renal-cell-carcinoma-cell-line-769p
#19
Bin Huang, Shun Jun Fu, Wen Zhe Fan, Zhong Hua Wang, Ze Bin Chen, Sheng Jie Guo, Jun Xing Chen, Shao Peng Qiu
Protein kinase C epsilon (PKCε), a member of the novel PKC family, is known to be a transforming oncogene and tumor biomarker for many human solid cancers including renal cell carcinoma (RCC). We isolated side population (SP) cells from the RCC 769P cell line, and proved that those cells possess cancer stem cell (CSC) characteristics. In this study, to identify the function of PKCε in cancer stemness of 769P SP cells, we reduced the expression of PKCε in those cells, following the results demonstrated that PKCε depletion had a negative correlation with the existence of SP cells in 769P cell line...
June 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27025124/-protein-kinase-c-expression-following-remote-ischemic-preconditioning-in-cardiac-surgery
#20
RANDOMIZED CONTROLLED TRIAL
A E Bautin, M M Galagudza, D M Tashkhanov, S V Datsenko, A O Marichev, A A Kostareva, E N Kravchuk, A Yu Bakanov, M L Gordeev
OBJECTIVE: To evaluate cardioprotective effects of remote ischemic preconditioning (RIPC) in cardiac surgery patients undergoing aortic valve replacement depending on the type of anesthesia and investigate the level of myocardial protein kinase C epsilon (PKC-ε) expression after RIPC. METHODS: In prospective randomized trial, forty eight patients aging from 50 to 75 years old (64 (56 ;69)) were included All patients were scheduled for aortic valve replacement using cardiopulmonary bypass (CPB)...
November 2015: Anesteziologiia i Reanimatologiia
keyword
keyword
20056
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"