Annop Kittithaworn A, Prerna Dogra, Jasmine Saini, Eke G Gruppen, Elizabeth Atkinson, Sara Achenbach, Kai Yu, Karthik Thangamuthu, Margery A Connelly, Robin Pf Dullaart, Irina Bancos
CONTEXT: Patients with adrenal hormone excess demonstrate increased cardiovascular risk and mortality. OBJECTIVE: We aimed to determine the impact of adrenal disorders on the inflammation marker GlycA, total branched-chain amino acids (BCAA), ketone bodies and the gut microbiome-derived metabolites trimethylamine N-oxide (TMAO) and betaine. METHODS: We conducted a single-center cross-sectional study of patients with nonfunctioning adenomas (NFA), mild autonomous cortisol secretion (MACS), primary aldosteronism (PA), Cushing syndrome (CS), pheochromocytoma/paragangliomas (PPGL), other benign or malignant adrenal masses, and adrenocortical carcinoma (ACC) between January 2015 and July 2022 (n=802)...
March 28, 2024: Journal of Clinical Endocrinology and Metabolism