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https://www.readbyqxmd.com/read/27936511/znf208-polymorphisms-associate-with-ischemic-stroke-in-southern-chinese-han-population
#1
Jianzhong Yu, Feng Zhou, Dong Luo, Nianzhen Wang, Chong Zhang, Tianbo Jin, Xiongfei Liang, Dan Yu
BACKGROUND: Ischemic stroke is one of the most common diseases with a high burden of neurological deficits, disability and death. Zinc finger protein 208 (ZNF208) was found to be involved in coronary heart disease, but little information was about its association with ischemic stroke. We performed this case-control study to elucidate the association between single-nucleotide polymorphisms (SNPs) within ZNF208 and risk of ischemic stroke in southern Chinese Han population. METHODS: A total of 799 subjects (400 cases and 399 health controls) were enrolled in this study...
December 9, 2016: Journal of Gene Medicine
https://www.readbyqxmd.com/read/27936064/gwrm-an-r-package-for-identifying-sources-of-variation-in-overdispersed-count-data
#2
Silverio Vílchez-López, Antonio José Sáez-Castillo, María José Olmo-Jiménez
Understanding why a random variable is actually random has been in the core of Statistics from its beginnings. The generalized Waring regression model for count data explains that inherent variability is given by three possible sources: randomness, liability and proneness. The model extends the negative binomial regression model and it is not included in the family of generalized linear models. In order to avoid that shortcoming, we developed the GWRM R package for fitting, describing and validating the model...
2016: PloS One
https://www.readbyqxmd.com/read/27936020/y-shape-osteotomy-in-ankylosing-spondylitis-a-prospective-case-series-with-minimum-2-year-follow-up
#3
Wenhao Hu, Jiayi Yu, Huawei Liu, Xuesong Zhang, Yan Wang
The aim of the study is to evaluate the efficacy of a spinal osteotomy technique, Y shape osteotomy, for correcting kyphosis in AS patients planned preoperatively with computer software-assistance. 36 consecutive AS patients with thoracolumbar kyphosis were treated with one-stage posterior Y shape osteotomy and preoperative surgical planning was done with the aid of the Surgimap Spine. Radiological parameters of simulation and immediate postoperation were documented. Clinical and radiological results were evaluated in the preoperative, the early postoperative periods and during the last follow-up...
2016: PloS One
https://www.readbyqxmd.com/read/27935994/comparison-of-polyethylene-wear-before-and-after-hip-revision-with-liner-exchange-fixed-with-the-original-locking-mechanism
#4
Xinfeng Gu, Jie He, Yiwen Tang, Yuxin Zheng
OBJECTIVE: To compare the wear of conventional ultra-high molecular weight polyethylene (CUHMWPE) and highly cross-linked polyethylene (HCLPE) in hip revision with liner exchange fixed with original locking mechanism using analysis of history medical data. METHODS: From Jan. 1, 2000, to Dec. 31, 2007, 26 patients (with 29 involved hips) underwent liner exchange revision fixed with the original locking mechanism due to wear of CUHMWPE and/or osteolysis. The mean age was 53 ± 9 years at the time of the primary total hip arthroplasty (THA) and 64 ± 9 years at the revision...
2016: PloS One
https://www.readbyqxmd.com/read/27935603/anterior-segment-imaging-based-subdivision-of-subjects-with-primary-angle-closure-glaucoma
#5
M E Nongpiur, E Atalay, T Gong, M Loh, H K Lee, M He, S A Perera, T Aung
PurposeThe purpose of this study was to identify whether it was possible to subdivide subjects with primary angle-closure glaucoma (PACG) based on anterior segment optical coherence tomography (ASOCT) imaging, and to determine the characteristics of such subgroups.MethodsWe evaluated 210 subjects with PACG. All subjects underwent gonioscopy and ASOCT imaging. Customized software was used to measure ASOCT parameters. An agglomerative hierarchical clustering method was first used to determine the optimum number of parameters to be included in the determination of subgroups...
December 9, 2016: Eye
https://www.readbyqxmd.com/read/27935271/self-powered-random-number-generator-based-on-coupled-triboelectric-and-electrostatic-induction-effects-at-the-liquid-dielectric-interface
#6
Aifang Yu, Xiangyu Chen, Haotian Cui, Libo Chen, Jianjun Luo, Wei Tang, Mingzeng Peng, Yang Zhang, Junyi Zhai, Zhong Lin Wang
Modern cryptography increasingly employs random numbers generated from physical sources in lieu of conventional software-based pseudorandom numbers, primarily owing to the great demand of unpredictable, indecipherable cryptographic keys from true random numbers for information security. Thus, far, the sole demonstration of true random numbers has been generated through thermal noise and/or quantum effects, which suffers from expensive and complex equipment. In this paper, we demonstrate a method for self-powered creation of true random numbers by using triboelectric technology to collect random signals from nature...
December 9, 2016: ACS Nano
https://www.readbyqxmd.com/read/27934889/accurate-quantitative-sensing-of-intracellular-ph-based-on-self-ratiometric-upconversion-luminescent-nanoprobe
#7
Cuixia Li, Jing Zuo, Li Zhang, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Qiqing Li, Huiying Zhao, Hong Zhang, Xianggui Kong
Accurate quantitation of intracellular pH (pHi) is of great importance in revealing the cellular activities and early warning of diseases. A series of fluorescence-based nano-bioprobes composed of different nanoparticles or/and dye pairs have already been developed for pHi sensing. Till now, biological auto-fluorescence background upon UV-Vis excitation and severe photo-bleaching of dyes are the two main factors impeding the accurate quantitative detection of pHi. Herein, we have developed a self-ratiometric luminescence nanoprobe based on förster resonant energy transfer (FRET) for probing pHi, in which pH-sensitive fluorescein isothiocyanate (FITC) and upconversion nanoparticles (UCNPs) were served as energy acceptor and donor, respectively...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934688/measurement-of-metabolome-samples-using-liquid-chromatography-mass-spectrometry-data-acquisition-and-processing
#8
Tomáš Pluskal, Mitsuhiro Yanagida
We present a protocol for metabolomic sample measurement using hydrophilic interaction chromatography (HILIC) combined with high-resolution Orbitrap mass spectrometry (MS). We also introduce a raw data processing method using MZmine 2 software, and include a list of 111 metabolite peaks (with their m/z values and retention times) previously identified in metabolome samples using this method.
December 1, 2016: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/27934476/characterization-and-synthesis-of-eudistidine-c-a-bioactive-marine-alkaloid-with-an-intriguing-molecular-scaffold
#9
Susanna T S Chan, Roger R Nani, Evan A Schauer, Gary E Martin, R Thomas Williamson, Josep Saurí, Alexei V Buevich, Wes A Schafer, Leo A Joyce, Andrew K L Goey, William D Figg, Tanya T Ransom, Curtis J Henrich, Tawnya C McKee, Arvin Moser, Scott A MacDonald, Shabana Khan, James B McMahon, Martin J Schnermann, Kirk R Gustafson
An extract of Eudistoma sp. provided eudistidine C (1), a heterocyclic alkaloid with a novel molecular framework. Eudistidine C (1) is a racemic natural product composed of a tetracyclic core structure further elaborated with a p-methoxyphenyl group and a phenol-substituted aminoimidazole moiety. This compound presented significant structure elucidation challenges due to the large number of heteroatoms and fully substituted carbons. These issues were mitigated by application of a new NMR pulse sequence (LR-HSQMBC) optimized to detect four- and five-bond heteronuclear correlations and the use of computer-assisted structure elucidation software...
November 18, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27934246/restricted-open-shell-g4-mp2-type-procedures
#10
Bun Chan, Amir Karton, Krishnan Raghavachari, Leo Radom
In the present study, we have reformulated the G4(MP2) and G4(MP2)-6X procedures for use with a restricted-open-shell (RO) formalism. We find that the resulting ROG4(MP2) and ROG4(MP2)-6X procedures generally perform comparably to the original unrestricted (U) variants, including their performance on radicals. Our analysis suggests that this is due mainly to the inclusion of empirical parameters that overcome the slightly less good performance of the U variants. However, a major practical advantage of ROG4(MP2) and ROG4(MP2)-6X is that they can be used in a wider range of computational chemistry software packages than the U analogs...
November 23, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27934098/plantmat-a-metabolomics-tool-for-predicting-the-specialized-metabolic-potential-of-a-system-and-for-large-scale-metabolite-identifications
#11
Feng Qiu, Dennis D Fine, Daniel J Wherritt, Zhentian Lei, Lloyd W Sumner
Custom software entitled Plant Metabolite Annotation Toolbox (PlantMAT) has been developed to address the number one grand challenge in metabolomics, which is the large-scale and confident identification of metabolites. PlantMAT uses informed phytochemical knowledge for the prediction of plant natural products such as saponins and glycosylated flavonoids through combinatorial enumeration of aglycone, glycosyl, and acyl subunits. Many of the predicted structures have yet to be characterized and are absent from traditional chemical databases, but have a higher probability of being present in planta...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27933738/exploratory-analysis-of-textual-data-from-the-mother-and-child-handbook-using-a-text-mining-method-ii-monthly-changes-in-the-words-recorded-by-mothers
#12
Miki Tagawa, Yoshio Matsuda, Tomoko Manaka, Makiko Kobayashi, Michitaka Ohwada, Shigeki Matsubara
AIM: The aim of the study was to examine the possibility of converting subjective textual data written in the free column space of the Mother and Child Handbook (MCH) into objective information using text mining and to compare any monthly changes in the words written by the mothers. METHODS: Pregnant women without complications (n = 60) were divided into two groups according to State-Trait Anxiety Inventory grade: low trait anxiety (group I, n = 39) and high trait anxiety (group II, n = 21)...
December 9, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27933712/the-importance-of-mrna-structure-in-determining-the-pathogenicity-of-synonymous-and-non-synonymous-mutations-in-haemophilia
#13
N Hamasaki-Katagiri, B C Lin, J Simon, R C Hunt, T Schiller, E Russek-Cohen, A A Komar, H Bar, C Kimchi-Sarfaty
INTRODUCTION: Mutational analysis is commonly used to support the diagnosis and management of haemophilia. This has allowed for the generation of large mutation databases which provide unparalleled insight into genotype-phenotype relationships. Haemophilia is associated with inversions, deletions, insertions, nonsense and missense mutations. Both synonymous and non-synonymous mutations influence the base pairing of messenger RNA (mRNA), which can alter mRNA structure, cellular half-life and ribosome processivity/elongation...
December 9, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27933641/method-of-b0-mapping-with-magnitude-based-correction-for-bipolar-two-point-dixon-cardiac-mri
#14
Junmin Liu, Dana C Peters, Maria Drangova
PURPOSE: The conventional two-point (2pt) Dixon technique explicitly estimates B0 map by performing phase unwrapping. When signal loss, phase singularity, artifacts, or spatially isolated regions corrupt the measured phase images, this unwrapping-based technique will face difficulty. This work aims to improve the reliability of B0 mapping by performing unwrapping error correction. METHOD: To detect the unwrapping-caused phase errors, we determined a magnitude-based fat/water mask and used it as reference to identify pixels being mismatched by the phase-based mask, which was derived from the B0-corrected phase term of the Hermitian product between echoes...
December 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27933530/visualization-of-results-from-systems-genetics-studies-in-chromosomal-context
#15
Karen Y Oróstica, Ricardo A Verdugo
This chapter describes methods currently available for visualizing results from systems genetics experiments. Here, we abstract from the statistical methods used for genetic mapping, which are dependent on the specific resource being used, i.e. F2, RILs, or outbred populations among others. We use a public dataset with results from a mouse eQTL experiment for three examples of visualization: genome-wide dot plots of marker-by-gene association, karyotype-like plots, and circos plots. Dot plots give a first overview of the results from eQTL mapping, allowing detecting genome-wide patterns of cis- and trans-genetic association to transcription level...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933520/mouse-genome-informatics-mgi-resources-for-mining-mouse-genetic-genomic-and-biological-data-in-support-of-primary-and-translational-research
#16
Janan T Eppig, Cynthia L Smith, Judith A Blake, Martin Ringwald, James A Kadin, Joel E Richardson, Carol J Bult
The Mouse Genome Informatics (MGI), resource ( www.informatics.jax.org ) has existed for over 25 years, and over this time its data content, informatics infrastructure, and user interfaces and tools have undergone dramatic changes (Eppig et al., Mamm Genome 26:272-284, 2015). Change has been driven by scientific methodological advances, rapid improvements in computational software, growth in computer hardware capacity, and the ongoing collaborative nature of the mouse genomics community in building resources and sharing data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933514/changes-in-cardiac-repolarisation-during-spontaneous-nocturnal-hypoglycaemia-in-subjects-with-type-1-diabetes-a-preliminary-report
#17
Minna L Koivikko, Tuomas Kenttä, Pasi I Salmela, Heikki V Huikuri, Juha S Perkiömäki
AIMS: Experimental studies have revealed that hypoglycaemia can result in morphological changes in electrocardiographic repolarisation in subjects with type 1 diabetes. However, the influence of spontaneous nocturnal hypoglycaemia on repolarisation morphology in a 'real life' situation is not clear. METHODS: Adults with type 1 diabetes (n = 11) underwent continuous glucose monitoring with a subcutaneous sensor and digital 12-lead ECG recording for three nights...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27933420/comparative-simulation-study-of-chemical-synthesis-of-functional-dadne-material
#18
Min Hsien Liu, Chuan Wen Liu
Amorphous molecular simulation to model the reaction species in the synthesis of chemically inert and energetic 1,1-diamino-2,2-dinitroethene (DADNE) explosive material was performed in this work. Nitromethane was selected as the starting reactant to undergo halogenation, nitration, deprotonation, intermolecular condensation, and dehydration to produce the target DADNE product. The Materials Studio (MS) forcite program allowed fast energy calculations and reliable geometric optimization of all aqueous molecular reaction systems (0...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27933407/simvascular-an-open-source-pipeline-for-cardiovascular-simulation
#19
REVIEW
Adam Updegrove, Nathan M Wilson, Jameson Merkow, Hongzhi Lan, Alison L Marsden, Shawn C Shadden
Patient-specific cardiovascular simulation has become a paradigm in cardiovascular research and is emerging as a powerful tool in basic, translational and clinical research. In this paper we discuss the recent development of a fully open-source SimVascular software package, which provides a complete pipeline from medical image data segmentation to patient-specific blood flow simulation and analysis. This package serves as a research tool for cardiovascular modeling and simulation, and has contributed to numerous advances in personalized medicine, surgical planning and medical device design...
December 8, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27933282/myocardial-perfusion-scintigraphy-dosimetry-optimal-use-of-spect-and-spect-ct-technologies-in-stress-first-imaging-protocol
#20
REVIEW
M Lecchi, S Malaspina, C Scabbio, V Gaudieri, A Del Sole
PURPOSE: Over the past decade, nuclear medicine experts have been seeking to minimize patient exposure to radiation in myocardial perfusion scintigraphy (MPS). This review describes the latest technological innovations in MPS, particularly with regard to dose reduction. METHODS: We searched in PubMed for original clinical papers in English, published after 2008, using the following research criteria: (dose) and ((reduction) or (reducing)) and ((myocardial) or (cardiac) or (heart)) and ((nuclear medicine) or (nuclear imaging) or (radionuclide) or (scintigraphy) or (SPET) or (SPECT))...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
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