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https://www.readbyqxmd.com/read/29166637/assessing-vessel-tone-during-coronary-artery-spasm-by-dual-acquisition-multidetector-computed-tomography-angiography
#1
Cai De Jin, Moo Hyun Kim, Eun Ju Kang, Young Rak Cho, Tae Ho Park, Ki Nam Lee, Victor Serebruany
BACKGROUND: Diminished vascular tone is an established biomarker of heart damage. Little is known about the extent of coronary vessel tone (CVT) with spasm as assessed by dual-acquisition multidetector computed tomography angiography (MCTA) in patients with vasospastic angina (VSA). OBJECTIVE: We evaluated the CVT modulated by intravenous nitrate injection (INI) using MCTA imaging in VSA patients. METHODS: Twenty-one VSA patients (60 ± 9 years; 76% males) who underwent initial MCTA (without morning vasodilation), followed by an intracoronary ergonovine provocation test were included...
November 23, 2017: Cardiology
https://www.readbyqxmd.com/read/29166574/altered-tnf-%C3%AE-response-by-aconibal-%C3%A2-and-methotrexate-in-a-lipopolysaccharide-induced-setting-of-inflammatory-conditions-potential-on-a-synergistic-combination
#2
Gunhyuk Park, Seoung Hoon Lee, Ji-Ye Han, Dal-Seok Oh
ETHNOPHARMACOLOGICAL RELEVANCE: Aconitum carmichaelii (AC) is a common herbal medicine used as anti-inflammatory and analgesic agent in Eastern Asia. In Korea, a commercial processed AC (Aconibal(®)) is traditionally used to treat the symptoms of spondylosis deformans and rheumatic pain. AIM OF STUDY: Rheumatoid arthritis (RA) is systemic and auto-immune disease characterized by chronic inflammation. Methotrexate (MTX) is often the first-line therapy for RA. If MTX monotherapy is ineffective or RA is initially severe, adding a tumor necrosis factor (TNF)-α inhibitor to the treatment can be beneficial...
November 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29166535/genetic-parameters-in-female-reproductive-traits-of-nile-tilapia-oreochromis-niloticus
#3
Grazyella M Yoshida, Carlos A L DE Oliveira, Natalí M Kunita, Gabriel S Rizzato, Ricardo P Ribeiro
Genetic parameters for reproductive traits in female Nile tilapia were estimated in this study using Bayesian inference method. The data set presented information from 451 Nile tilapia females that were evaluated at two different places in Maringá - Paraná - Brazil (hapas of 1 and 10 m³) and at one location in Alfenas - Minas Gerais - Brazil. A spawning examination was conducted once a week from October 2012 to March 2013 for a total of 23 weeks of evaluation. Single-trait analyses for spawning success, multiple spawning, spawning frequency, and volume of eggs/female were performed by using the software MTGSAM Threshold...
2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29166441/transfer-of-knowledge-in-international-cooperation-the-farmanguinhos-smm-case
#4
Samuel Araujo Gomes da Silva, Roberto Gonzalez Duarte, José Márcio de Castro
OBJECTIVE: To analyze the influence of four mechanisms of knowledge transfer (training, technical visits, expatriation, and standard operating procedures) on the different dimensions (potential and realized) of absorptive capacity in international technical cooperation. METHODS: We examine the case of implementation of the Sociedade Moçambicana de Medicamentos. Data have been collected using semi-structured interviews (applied to 21 professionals of the Sociedade Moçambicana de Medicamentos, Farmanguinhos, FIOCRUZ, and Itamaraty) and official documents...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166439/the-geographic-information-system-applied-to-study-schistosomiasis-in-pernambuco
#5
Verônica Santos Barbosa, Rodrigo Moraes Loyo, Ricardo José de Paula Souza E Guimarães, Constança Simões Barbosa
OBJECTIVE: Diagnose risk environments for schistosomiasis in coastal localities of Pernambuco using geoprocessing techniques. METHODS: A coproscopic and malacological survey were carried out in the Forte Orange and Serrambi areas. Environmental variables (temperature, salinity, pH, total dissolved solids and water fecal coliform dosage) were collected from Biomphalaria breeding sites or foci. The spatial analysis was performed using ArcGis 10.1 software, applying the kernel estimator, elevation map, and distance map...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166287/assessment-of-genomic-inbreeding-in-polish-konik-horses
#6
S Kamiński, D M Hering, Z Jaworski, T Zabolewicz, A Ruść
The aim of this study was to assess the inbreeding coefficient of Polish Konik horses based on runs of homozygosity (ROH). Ninety six horses kept in 6 herds located across Poland were genotyped with the use of EquineSNP60 BeadChip (Illumina). SNP markers with a Minor Allele Frequency lower than 0.01 and SNPs assigned to chromosome X or Y were excluded from the study. A total of 50 708 SNPs were included for statistical analysis (SVS software, Golden Helix). The analysis showed that the population is in genetic equilibrium, with He and Ho estimates both equal to 0...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166148/in-vivo-differentiation-of-uric-acid-versus-non-uric-acid-urinary-calculi-with-third-generation-dual-source-dual-energy-ct-at-reduced-radiation-dose
#7
Axelle Franken, Pierre Alain Gevenois, Alain Van Muylem, Nigel Howarth, Caroline Keyzer
OBJECTIVE: The objective of our study was to evaluate in vivo urinary calculus characterization with third-generation dual-source dual-energy CT (DECT) at reduced versus standard radiation dose. SUBJECTS AND METHODS: One hundred fifty-three patients requiring unenhanced CT for suspected or known urolithiasis were prospectively included in our study. They underwent two acquisitions at reduced-dose CT (90 kV and 50 mAsref; Sn150 kV and 31 mAsref, where Sn denotes the interposition of a tin filter in the high-energy beam) and standard-dose CT (90 kV and 50 mAsref; Sn150 kV and 94 mAsref)...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29165996/itop-q-an-intelligent-tool-for-top-down-proteomics-quantitation-us-ing-dyamond-algorithm
#8
Hui-Yin Chang, Ching-Tai Chen, Chu-Ling Ko, Yi-Ju Chen, Yu-Ju Chen, Wen-Lian Hsu, Chiun-Gung Juo, Ting-Yi Sung
Top-down proteomics using liquid chromatogram coupled with mass spectrometry has been increasingly applied for analyzing intact proteins to study genetic variation, alternative splicing, and post-translational modifications (PTMs) of the proteins (proteoforms). However, only a few tools have been developed for charge state deconvolution, monoisotopic/average molecular weight determination and quantitation of proteoforms from LC-MS1 spectra. Though Decon2LS and MASH Suite Pro have been available to provide intra-spectrum charge state deconvolution and quantitation, manual processing is still required to quantify proteoforms across multiple MS1 spectra...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29165934/first-rapid-assessment-of-avoidable-blindness-survey-in-the-maldives-prevalence-and-causes-of-blindness-and-cataract-surgery
#9
Ubeydulla Thoufeeq, Taraprasad Das, Hans Limburg, Maharshi Maitra, Lapam Panda, Asim Sil, John Trevelyan, Yuddha Sapkota
PURPOSE: A nationwide rapid assessment of avoidable blindness survey was undertaken in the Maldives among people aged 50 years or more to assess the prevalence and causes of blindness and visual impairment, cataract surgical coverage, cataract surgery outcome, and barriers to uptake of cataract surgical services. DESIGN: Prospective population-based study. METHODS: In the cluster sampling probability proportionate to size method, 3100 participants in 62 clusters across all 20 atolls were enrolled through house-to-house visits...
November 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29165915/development-and-implementation-of-a-radiation-therapy-incident-learning-system-compatible-with-local-workflow-and-a-national-taxonomy
#10
Logan Montgomery, Palma Fava, Carolyn R Freeman, Tarek Hijal, Ciro Maietta, William Parker, John Kildea
PURPOSE: Collaborative incident learning initiatives in radiation therapy promise to improve and standardize the quality of care provided by participating institutions. However, the software interfaces provided with such initiatives must accommodate all participants and thus are not optimized for the workflows of individual radiation therapy centers. This article describes the development and implementation of a radiation therapy incident learning system that is optimized for a clinical workflow and uses the taxonomy of the Canadian National System for Incident Reporting - Radiation Treatment (NSIR-RT)...
November 22, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29165744/hypothermia-therapy-after-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#11
Lige Leng
The purpose of this article was mainly focus on in patients with TBI, does or not hypothermia improved mortality and/or chance of good neurologic outcome compared with standard of care alone. We performed a comprehensive search strategy. Articles were eliminated in a stepwise fashion. Data from each study was entered in Review Manager (RevMan) software version 5.0 when reported. 7 studies, including 1331 patients confirmed to all selection criteria and were identified. This meta-analysis got all data of 7 articles together to come to a conclusion, besides that, it also carried on a detailed analysis of different classification, trying to outline the possible mechanism...
October 29, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29165610/gramene-2018-unifying-comparative-genomics-and-pathway-resources-for-plant-research
#12
Marcela K Tello-Ruiz, Sushma Naithani, Joshua C Stein, Parul Gupta, Michael Campbell, Andrew Olson, Sharon Wei, Justin Preece, Matthew J Geniza, Yinping Jiao, Young Koung Lee, Bo Wang, Joseph Mulvaney, Kapeel Chougule, Justin Elser, Noor Al-Bader, Sunita Kumari, James Thomason, Vivek Kumar, Daniel M Bolser, Guy Naamati, Electra Tapanari, Nuno Fonseca, Laura Huerta, Haider Iqbal, Maria Keays, Alfonso Munoz-Pomer Fuentes, Amy Tang, Antonio Fabregat, Peter D'Eustachio, Joel Weiser, Lincoln D Stein, Robert Petryszak, Irene Papatheodorou, Paul J Kersey, Patti Lockhart, Crispin Taylor, Pankaj Jaiswal, Doreen Ware
Gramene (http://www.gramene.org) is a knowledgebase for comparative functional analysis in major crops and model plant species. The current release, #54, includes over 1.7 million genes from 44 reference genomes, most of which were organized into 62,367 gene families through orthologous and paralogous gene classification, whole-genome alignments, and synteny. Additional gene annotations include ontology-based protein structure and function; genetic, epigenetic, and phenotypic diversity; and pathway associations...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165558/-she-had-a-smile-on-her-face-as-wide-as-the-great-australian-bite-a-qualitative-examination-of-family-perceptions-of-a-therapeutic-robot-and-a-plush-toy
#13
Wendy Moyle, Marguerite Bramble, Cindy J Jones, Jenny E Murfield, Barbara J Bowers
Background and Objectives: Recent years have seen social robotic pets introduced as a means of treating behavioral and psychological symptoms of dementia, and many show promising potential. In this study, we sought to explore family members' perceptions of the Japanese-developed baby harp seal, Paro (version 9), and a look-alike, nonrobotic Plush Toy, when used by their relative with dementia for 15 min, 3 afternoons per week for 10 weeks. Research Design and Method: The study employed a descriptive qualitative approach, which was nested within a larger cluster randomized controlled trial...
November 19, 2017: Gerontologist
https://www.readbyqxmd.com/read/29165544/rna-methylation-and-diseases-experimental-results-databases-web-servers-and-computational-models
#14
Xing Chen, Ya-Zhou Sun, Hui Liu, Lin Zhang, Jian-Qiang Li, Jia Meng
Ribonucleic acid (RNA) methylation is a type of posttranscriptional modifications occurring in all kingdoms of life. It is strongly related to important biological process, thus making it linked to a number of human diseases. Owing to the development of high-throughput sequencing technology, plenty of achievement had been obtained in RNA methylation research recently. Meanwhile, various computational models have been developed to analyze and mining increasing RNA methylation data. In this review, we first made a brief introduction about eight types of most popular RNA methylation, the biological functions of RNA methylation, the relationship between RNA methylation and disease and five important RNA methylation-related diseases...
November 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29165407/-uveitis-associated-hla-class-1-histocompatibility-antigens
#15
I Yu Razumova, A A Godzenko, I A Guseva, O K Vorob'eva
AIM: to evaluate the diagnostic and prognostic significance of HLA class 1 histocompatibility antigens in the development of anterior uveitis. MATERIAL AND METHODS: A total of 137 patients with anterior uveitis followed up at the Research Institute of Eye Diseases in 2009-2016 were tested for HLA antigens (A and B loci). The average patient's age was 29±12.4 years. All patients underwent a thorough medical interview with clinical and laboratory assessment. In case of suspected association with systemic disease, the patients were referred for consultation at the V...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165357/new-metabolites-of-coumarin-detected-in-human-urine-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry
#16
Letícia Paula Leonart, João Cleverson Gasparetto, Flávia Lada Degaut Pontes, Letícia Bonancio Cerqueira, Thais Martins Guimarães de Francisco, Roberto Pontarolo
Coumarin (1,2-benzopyrone) is a natural compound whose metabolism in humans was established in the 1970s. However, a new metabolite was recently identified in human plasma, indicating that the metabolism of coumarin has not been completely elucidated. To complement the knowledge of its metabolism, a rapid and sensitive method using UPLC-QTOF-MS was developed. A total of 12 metabolites was identified using MetaboLynxTM software, including eight metabolites not previously reported in human urine. The identified biotransformation included hydroxylation, glucuronidation, sulfation, methylation, and conjugation with N-acetylcysteine...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29165356/fast-detection-of-a-brca2-large-genomic-duplication-by-next-generation-sequencing-as-a-single-procedure-a-case-report
#17
Marcella Nunziato, Flavio Starnone, Barbara Lombardo, Matilde Pensabene, Caterina Condello, Francesco Verdesca, Chiara Carlomagno, Sabino De Placido, Lucio Pastore, Francesco Salvatore, Valeria D'Argenio
The aim of this study was to verify the reliability of a next generation sequencing (NGS)-based method as a strategy to detect all possible BRCA mutations, including large genomic rearrangements. Genomic DNA was obtained from a peripheral blood sample provided by a patient from Southern Italy with early onset breast cancer and a family history of diverse cancers. BRCA molecular analysis was performed by NGS, and sequence data were analyzed using two software packages. Comparative genomic hybridization (CGH) array was used as confirmatory method...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29165116/circular-rna-profiles-in-mouse-lung-tissue-induced-by-radon
#18
Weiwei Pei, Lijing Tao, Leshuai W Zhang, Shuyu Zhang, Jianping Cao, Yang Jiao, Jian Tong, Jihua Nie
BACKGROUND: Radon is a known human lung carcinogen, whose underlying carcinogenic mechanism remains unclear. Recently, circular RNA (circRNA), a class of endogenous non-protein coding RNAs that contain a circular loop, was found to exhibit multiple biological effects. In this study, circRNA profiles in mouse lung tissues between control and radon exposure were analyzed. METHODS: Six mice were exposed to radon at concentration of 100,000 Bq/m(3), 12 h/d, for up to cumulative doses of 60 working level months (WLM)...
April 7, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165085/a-speech-recognition-based-solution-for-the-automatic-detection-of-mild-cognitive-impairment-from-spontaneous-speech
#19
Laszlo Toth, Ildiko Hoffmann, Gabor Gosztolya, Veronika Vincze, Greta Szatloczki, Zoltan Banreti, Magdolna Pakaski, Janos Kalman
BACKGROUND: Even today the reliable diagnosis of the prodromal stages of Alzheimer's disease (AD) remains a great challenge. Our research focuses on the earliest detectable indicators of cognitive decline in mild cognitive impairment (MCI). Since the presence of language impairment has been reported even in the mild stage of AD, the aim of this study is to develop a sensitive neuropsychological screening method which is based on the analysis of spontaneous speech production during performing a memory task...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29164924/towards-enhanced-pet-quantification-in-clinical-oncology
#20
Habib Zaidi, Nicolas Karakatsanis
Positron emission tomography (PET) has, since its inception, established itself as the imaging modality of choice for the in vivo quantitative assessment of molecular targets in a wide range of biochemical processes underlying tumour physiology. PET image quantification enables to ascertain a direct link between the time-varying activity concentration in organs/tissues and the fundamental parameters portraying the biological processes at the cellular level being assessed. However, the quantitative potential of PET may be affected by a number of factors related to physical effects, hardware and software system specifications, tracer kinetics, motion, scan protocol design and limitations in current image-derived PET metrics...
November 22, 2017: British Journal of Radiology
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