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Newborn magnetic resonance

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https://www.readbyqxmd.com/read/29212618/altered-cerebral-perfusion-in-infants-born-preterm-compared-with-infants-born-full-term
#1
Marine Bouyssi-Kobar, Jonathan Murnick, Marie Brossard-Racine, Taeun Chang, Eman Mahdi, Marni Jacobs, Catherine Limperopoulos
OBJECTIVES: To compare regional cerebral cortical blood flow (CBF) in infants born very preterm at term-equivalent age (TEA) and healthy newborns born full term and to examine the impact of clinical risk factors on CBF in the cohort born preterm. STUDY DESIGN: This prospective, cross-sectional study included infants born very preterm (gestational age at birth <32 weeks; birth weight <1500 g) and healthy infants born full term. Using noninvasive 3T arterial spin labeling magnetic resonance imaging, we quantified regional CBF in the cerebral cortex: sensorimotor/auditory/visual cortex, superior medial/dorsolateral prefrontal cortex, anterior cingulate cortex (ACC)/posterior cingulate cortex, insula, and lateral posterior parietal cortex, as well as in the brainstem, and deep gray matter...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29212395/prenatal-prediction-of-small-for-gestational-age-neonates-using-mr-imaging-comparison-with-conventional-2d-ultrasound
#2
Andrew Carlin, Caroline Kadji, Riccardo De Angelis, Mieke M Cannie, Jacques C Jani
PURPOSE: To evaluate the performance of estimating fetal weight (EFW) using magnetic resonance (MR) imaging as compared with two-dimensional (2D) ultrasound (US) in the prediction of small-for-gestational age neonates (SGA). MATERIALS & METHODS: Written informed consent was obtained for this Ethical Committee approved study. Between March 2011 and May 2016, women with singleton pregnancies underwent US-EFW and MR-EFW within 48 h before delivery. US-EFW was based on Hadlock et al...
December 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29209885/neuroimaging-findings-associated-with-congenital-zika-virus-syndrome-case-series-at-the-time-of-first-epidemic-outbreak-in-pernambuco-state-brazil
#3
Pedro Pires, Patricia Jungmann, Jully Moura Galvão, Adriano Hazin, Luiza Menezes, Ricardo Ximenes, Gabriele Tonni, Edward Araujo Júnior
PURPOSE: This study aimed to describe the prenatal and postnatal neuroimaging and clinical findings in a clinical series following congenital Zika virus syndrome during the first epidemic Zika virus (ZIKV) outbreak in the State of Pernambuco, Brazil. METHODS: We (the authors) conducted a retrospective study of a prospectively collected case series of fetuses and neonates with microcephaly born to mothers with presumed/confirmed congenital ZIKV syndrome. Prenatal ultrasound findings were reviewed to identify potential central nervous system (CNS) abnormalities...
December 5, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29201824/assessment-of-preterm-infants-using-the-bayley-iii-scales-in-korea
#4
Sung Ho Ahn, Soo A Kim
Objective: To assess the well-being of preterm newborns using the Bayley-III scales in a Korean-based population, and to evaluate the perinatal risk factors influencing developmental outcome. Methods: Using the Bayley-III scales, we assessed 120 preterm infants who were referred for evaluation of neurodevelopmental performance. We subdivided them into an extremely preterm group (n=18) and a very/moderate to late preterm group (n=102). Bayley-III mean scores and the rate of infants showing a delay were compared for both groups...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29182578/dietary-sialyllactose-influences-sialic-acid-concentrations-in-the-prefrontal-cortex-and-magnetic-resonance-imaging-measures-in-corpus-callosum-of-young-pigs
#5
Austin T Mudd, Stephen A Fleming, Beau Labhart, Maciej Chichlowski, Brian M Berg, Sharon M Donovan, Ryan N Dilger
Sialic acid (SA) is a key component of gangliosides and neural cell adhesion molecules important during neurodevelopment. Human milk contains SA in the form of sialyllactose (SL) an abundant oligosaccharide. To better understand the potential role of dietary SL on neurodevelopment, the effects of varying doses of dietary SL on brain SA content and neuroimaging markers of development were assessed in a newborn piglet model. Thirty-eight male pigs were provided one of four experimental diets from 2 to 32 days of age...
November 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29176025/a-newborn-with-combined-pituitary-hormone-deficiency-developing-shock-and-sludge
#6
Yasuhiro Ueda, Hayato Aoyagi, Toshihiro Tajima
A male neonate was born at 41 weeks of gestation with a birth weight of 3320 g. Artificial respiratory management was required due to respiratory disturbance 1 h after birth, and subsequently catecholamine-refractory low cardiac output-induced shock occurred. Severe combined pituitary hormone deficiency (CPHD) was considered based on the presence of his respiratory disturbance, hypoglycemia and micropenis. After hydrocortisone (HDC) administration, circulatory dynamics rapidly improved. Brain magnetic resonance imaging (MRI) showed aplasia of the anterior pituitary gland and ectopic posterior gland...
November 25, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29167058/neuroimaging-findings-in-normocephalic-newborns-with-intrauterine-zika-virus-exposure
#7
Sarah B Mulkey, Gilbert Vezina, Dorothy I Bulas, Zarir Khademian, Anna Blask, Youssef Kousa, Caitlin Cristante, Lindsay Pesacreta, Adre J du Plessis, Roberta L DeBiasi
BACKGROUND: Congenital Zika infection can result in a spectrum of neurological abnormalities in the newborn. Newborns exposed to Zika virus in utero often have neuroimaging as part of their clinical evaluation. METHODS: Through the Congenital Zika Program at Children's National Health System in Washington DC, we performed fetal or neonatal neuroimaging, including magnetic resonance imaging and ultrasound, on over 70 fetuses or neonates with intrauterine Zika exposure...
October 19, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29150375/type-i-interferon-and-proinflammatory-cytokine-levels-in-cerebrospinal-fluid-of-newborns-with-rotavirus-associated-leukoencephalopathy
#8
Kyung Yeon Lee, Chang Hoon Moon, Seong Hoon Choi
OBJECTIVE: The purpose of this study was to identify whether there is an increase in type I interferon and proinflammatory cytokine levels in the cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy. METHODS: Levels of type I interferons (interferon-alpha and interferon-beta) and proinflammatory cytokines (interleukin-6 and interferon-gamma) were measured in the cerebrospinal fluid of 23 newborns with rotavirus-associated leukoencephalopathy (patient group) and 39 infants under 90 days-of-age (control group)...
November 14, 2017: Brain & Development
https://www.readbyqxmd.com/read/29129133/association-between-hypocapnia-and-ventilation-during-the-first-days-of-life-and-brain-injury-in-asphyxiated-newborns-treated-with-hypothermia
#9
Maria Agustina Lopez Laporte, Hui Wang, Priscille-Nice Sanon, Stephanie Barbosa Vargas, Julie Maluorni, Emmanouil Rampakakis, Pia Wintermark
PURPOSE: Therapeutic hypothermia is the standard treatment for asphyxiated newborns. Since hypocapnia is common in these newborns, the aim of this study was to assess the association between hypocapnia, ventilation and brain injury. METHODS: We conducted a retrospective cohort study of all asphyxiated newborns treated with hypothermia from 2008 to 2014. Partial pressure of carbon dioxide (pCO2), ventilatory status and modes of ventilation were recorded during the first 4 days of life...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29108501/occult-massive-visceral-fat-necrosis-following-therapeutic-hypothermia-for-neonatal-encephalopathy
#10
Salwa Khedr, Anna Piskorski, Adrienne R Bingham, Justin Goldstein, Abbot R Laptook, Monique E De Paepe
Therapeutic hypothermia (head or whole-body cooling) improves survival and neurodevelopmental outcome in term newborns with moderate-to-severe encephalopathy. Hypothermia treatment is well tolerated; the most common side effect is thrombocytopenia. In about 1% of infants, focal subcutaneous fat necrosis has been reported. We describe a case of clinically unsuspected massive visceral fat necrosis in a term infant with Apgar score 0 at 1 min ("resuscitated apparently stillborn" infant) who was treated with therapeutic hypothermia for 72 h and expired on the 25th day of life following a neonatal course complicated by severe encephalopathy, pulmonary artery hypertension, persistent thrombocytopenia, hypoglycemia, and severe basal ganglia-thalamic abnormalities on magnetic resonance imaging...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29106509/fmri-based-neuronal-response-to-new-odorants-in-the-newborn-brain
#11
Alexandra Adam-Darque, Frédéric Grouiller, Lana Vasung, Russia Ha-Vinh Leuchter, Philippe Pollien, François Lazeyras, Petra S Hüppi
The sense of smell is one of the oldest and the most primitive senses mammals possess, it helps to evaluate the surrounding environment. From birth, smell is an important sensory modality, highly relevant for neonatal behavioral adaptation. Even though human newborns seem to be able to perceive and react to olfactory stimuli, there is still a lack of knowledge about the ontogeny of smell and the underlying central processing involved in odor perception in newborns. Brain networks involved in chemosensory perception of odorants are well described in adults, however in newborns there is no evidence that central olfaction is functional given the largely unmyelinated neonatal central nervous system...
July 6, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29095291/relevance-of-urinary-s100b-protein-levels-as-a-short-term-prognostic-biomarker-in-asphyxiated-infants-treated-with-hypothermia
#12
Ayham Alshweki, Alejandro Pérez-Muñuzuri, Olalla López-Suárez, Ana Baña, Maria L Couce
The initial diagnosis of neonatal hypoxic-ischemic encephalopathy is based on nervous system clinical manifestations. The use of biomarkers to monitor brain injury and evaluate neuroprotective effects allows early intervention and treatment. This study was designed to determine the short-term prognostic significance of urinary S100B calcium-binding protein (S100B) in asphyxiated newborns treated with hypothermia.An observational prospective study was conducted over a period of 5 years in 31 newborns with hypoxic-ischemic encephalopathy who received therapeutic hypothermia...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29080379/probabilistic-tractography-based-thalamic-parcellation-in-healthy-newborns-and-newborns-with-congenital-heart-disease
#13
Camilo Jaimes, Henry H Cheng, Janet Soul, Silvina Ferradal, Yogesh Rathi, Borjan Gagoski, Jane W Newburger, P Ellen Grant, Lilla Zöllei
BACKGROUND: Given the central role of the thalamus in motor, sensory, and cognitive development, methods to study emerging thalamocortical connectivity in early infancy are of great interest. PURPOSE: To determine the feasibility of performing probabilistic tractography-based thalamic parcellation (PTbTP) in typically developing (TD) neonates and to compare the results with a pilot sample of neonates with congenital heart disease (CHD). STUDY TYPE: Institutional Review Board (IRB)-approved cross-sectional study...
October 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29075839/occult-spinal-dysraphisms-in-newborns-with-skin-markers-role-of-ultrasonography-and-magnetic-resonance-imaging
#14
E Ausili, G Maresca, L Massimi, L Morgante, C Romagnoli, C Rendeli
PURPOSE: The purpose of this paper is to investigate occult spinal dysraphisms (OSD) using lumbar ultrasonography (LUS) in newborns presenting with specific skin markers or sacrococcygeal dimple. METHOD: From 2012 to 2015, we performed LUS in newborns with cutaneous stigmata and/or sacroccygeal dimple. Magnetic resonance imaging (MRI) was performed in all patients with abnormal ultrasound or features of neurological involvement in order to detect spinal lesions...
October 27, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29030170/in-utero-negativization-of-zika-virus-in-a-case-with-serious-central-nervous-system-abnormalities
#15
Carlota Rodó, Anna Suy, Elena Sulleiro, Antoni Soriano-Arandes, Andrés Antón, Itziar García, Silvia Arévalo, Élida Vázquez, Ana Vázquez, Fernando de Ory, M Paz Sánchez-Seco, Carlos Rodrigo, Tomás Pumarola, Elena Carreras
OBJECTIVES: To describe a case of a pregnant woman with Zika virus infection and severe fetal brain malformations. METHODS: Serial ultrasound measurements, fetal magnetic resonance imaging results, laboratory and amniocentesis results, and perinatal outcomes of the pregnant woman and her neonate are reported. RESULTS: Zika virus tested positive in amniotic fluid at 19 weeks while being negative at delivery. The newborn did not meet the case definition of congenital Zika virus syndrome because neither the Zika virus RNA nor immunoglobulin M antibodies were detected; however, prenatal brain lesions were confirmed after birth...
October 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28990589/which-anthropometric-measures-best-reflect-neonatal-adiposity
#16
L-W Chen, M-T Tint, M V Fortier, I M Aris, Lp-C Shek, K H Tan, S-Y Chan, P D Gluckman, Y-S Chong, K M Godfrey, V S Rajadurai, F Yap, M S Kramer, Y S Lee
BACKGROUND: Studying the determinants and the long-term consequences of fetal adipose accretion requires accurate assessment of neonatal body composition. In large epidemiological studies, in-depth body composition measurement methods are usually not feasible for cost and logistical reasons, and there is a need to identify anthropometric measures that adequately reflect neonatal adiposity. METHODS: In a multiethnic Asian mother-offspring cohort in Singapore, anthropometric measures (weight, length, abdominal circumference, skinfold thicknesses) were measured using standardized protocols in newborn infants, and anthropometric indices [weight/length, weight/length(2) (body mass index, BMI), weight/length(3) (ponderal index, PI)] derived...
October 9, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28926319/case-246-mr-imaging-of-a-complex-cystic-mass-in-a-newborn-girl
#17
Aditi Shruti, George S Wu
History A 6-day-old female neonate presented to the outpatient pediatric surgery clinic for evaluation of a possible prenatal abdominal mass. The neonate was delivered at term via cesarean section due to macrosomia, with a reported birth weight of 11 lb 8.7 oz (5.23 kg). The patient's postnatal course was remarkable for resolving neonatal hyperbilirubinemia. A physical examination was remarkable for a palpable mass in the abdomen. Maternal risk factors included class II obesity, type 2 diabetes, and metabolic syndrome...
October 2017: Radiology
https://www.readbyqxmd.com/read/28906338/a-pharmacokinetics-efficacy-and-safety-study-of-gadoterate-meglumine-in-pediatric-subjects-aged-younger-than-2-years
#18
Mario Scala, Meriam Koob, Sophie de Buttet, Philippe Bourrinet, Mathieu Felices, Elzbieta Jurkiewicz
OBJECTIVES: The primary objective of this study was to investigate the pharmacokinetic profile of gadoterate meglumine in pediatric patients younger than 2 years; the secondary objectives were to document its efficacy and safety. MATERIAL AND METHODS: This was a Phase IV open-label, prospective study conducted in 9 centers (4 countries). Forty-five patients younger than 2 years with normal estimated glomerular filtration rate and scheduled to undergo routine gadolinium-enhanced magnetic resonance imaging (MRI) of any organ were included and received a single intravenous injection of gadoterate meglumine (0...
September 12, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28904585/is-it-the-monster-teratoma-or-simply-meningomyelocele-our-experience-of-histological-surprise
#19
Suyash Singh, Jayesh Sardhara, Pradeep Sharma, Arun Kumar Srivastava, Kuntal Kanti Das, Kamlesh S Bhaisora, Anant Mehrotra, Awadhesh Kumar Jaiswal, Sanjay Behari, Raj Kumar
Teratomas are one of the most common tumors in newborn with excellent prognosis arises from totipotent primordial germ cells harboring two or three germ cell layers. The tumor has been titled "Great masquerade." The teratomas of sacrococcygeal region present with lower limb weakness, urinary or bowel obstruction, and swelling at lower back or intrauterine mass in ultrasound or complicated delivery. A 2-month-old male child presented with complaints of swelling over lumbosacral region with discharging punctum since birth...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28898497/a-pediatric-structural-mri-analysis-of-healthy-brain-development-from-newborns-to-young-adults
#20
Jacob Levman, Patrick MacDonald, Ashley Ruyan Lim, Cynthia Forgeron, Emi Takahashi
Assessment of healthy brain maturation can be useful toward better understanding natural patterns of brain growth and toward the characterization of a variety of neurodevelopmental disorders as deviations from normal growth trajectories. Structural magnetic resonance imaging (MRI) provides excellent soft-tissue contrast, which allows for the assessment of gray and white matter in the developing brain. We performed a large-scale retrospective analysis of 993 pediatric structural brain MRI examinations of healthy subjects (n = 988, aged 0-32 years) imaged clinically at 3 T, and extracted a wide variety of measurements such as white matter volumes, cortical thickness, and gyral curvature localized to subregions of the brain...
December 2017: Human Brain Mapping
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