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https://www.readbyqxmd.com/read/28738276/the-impact-of-accelerated-high-frequency-rtms-on-brain-neurochemicals-in-treatment-resistant-depression-insights-from-1-h-mr-spectroscopy
#1
Chris Baeken, Jean-Pascal Lefaucheur, Peter Van Schuerbeek
OBJECTIVE: Although accelerated repetitive transcranial magnetic stimulation (rTMS) designs seem to be able to alleviate mood over a relatively short period of time, no studies yet examined the cellular effects on neurochemicals with regard to working mechanisms, safety and neural integrity. METHODS: Eighteen right-handed antidepressant-free unipolar treatment resistant depressed (TRD) patients participated in this sham-controlled accelerated high frequency (aHF)-rTMS (1)H MR spectroscopy study applied to the left dorsolateral prefrontal cortex (DLPFC)...
July 6, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28731977/interventions-for-neuropathic-pain-an-overview-of-systematic-reviews
#2
Svjetlana Dosenovic, Antonia Jelicic Kadic, Maja Miljanovic, Marina Biocic, Krste Boric, Marija Cavar, Nikolina Markovina, Katarina Vucic, Livia Puljak
Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains unsatisfactory. We systematically summarized evidence from systematic reviews (SRs) of randomized controlled trials on interventions for NeuP. Five electronic databases were searched up to March 2015. Study quality was analyzed using A Measurement Tool to Assess Systematic Reviews. The most common interventions in 97 included SRs were pharmacologic (59%) and surgical (15%). The majority of analyzed SRs were of medium quality...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28713286/mechanism-of-action-for-rtms-a-working-hypothesis-based-on-animal-studies
#3
REVIEW
Thangavelu Soundara Rajan, Maria F M Ghilardi, Hoau-Yan Wang, Emanuela Mazzon, Placido Bramanti, Domenico Restivo, Angelo Quartarone
Experiments in rodents have elucidated some of the molecular mechanisms underlying repetitive transcranial magnetic stimulation (rTMS). These studies may be useful in a translational perspective so that future TMS studies in rodents can closely match human TMS protocols designed for therapeutic purposes. In the present work we will review the effects of rTMS on glutamate neurotransmission which in turn induce persistent changes in synaptic activity. In particular, we will focus on the role of NMDA and non-NMDA transmission and on the permissive role of BDNF-TrKB interaction in the rTMS induced after-effects...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28704292/improvement-of-higher-brain-dysfunction-after-brain-injury-by-repetitive-transcranial-magnetic-stimulation-and-intensive-rehabilitation-therapy-case-report
#4
Takatoshi Hara, Masahiro Abo, Nobuyuki Sasaki, Naoki Yamada, Masachika Niimi, Mari Kenmoku, Kastuya Kawakami, Reiko Saito
Repetitive transcranial magnetic stimulation (rTMS) and intensive cognitive rehabilitation (CR) were administered to two patients with cognitive dysfunction following brain injury. The first case was a 67-year-old man who presented with memory dysfunction, attention dysfunction, and decreased insight following diffuse axonal injury. High-frequency rTMS (10 Hz, 2400 pulses/day) targeting the anterior cingulate using a navigation system and CR were administered for 12 days at 1 year from the onset of injury...
July 12, 2017: Neuroreport
https://www.readbyqxmd.com/read/28694022/the-clinical-utility-of-repetitive-transcranial-magnetic-stimulation-in-reducing-the-risks-of-transitioning-from-acute-to-chronic-pain-in-traumatically-injured-patients
#5
REVIEW
Marianne Jodoin, Dominique Rouleau, Camille Larson-Dupuis, Nadia Gosselin, Louis De Beaumont
Pain is a multifaceted condition and a major ongoing challenge for healthcare professionals having to treat patients in whom pain put them at risk of developing other conditions. Significant efforts have been invested in both clinical and research settings in an attempt to demystify the mechanisms at stake and develop optimal treatments as well as to reduce individual and societal costs. It is now universally accepted that neuroinflammation and central sensitization are two key underlying factors causing pain chronification as they result from maladaptive central nervous system plasticity...
July 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28689295/inhibitory-rtms-applied-on-somatosensory-cortex-in-wilson-s-disease-patients-with-hand-dystonia
#6
Pierre Lozeron, Aurélia Poujois, Elodie Meppiel, Sana Masmoudi, Thierry Peron Magnan, Eric Vicaut, Emmanuel Houdart, Jean-Pierre Guichard, Jean-Marc Trocello, France Woimant, Nathalie Kubis
Hand dystonia is a common complication of Wilson's disease (WD), responsible for handwriting difficulties and disability. Alteration of sensorimotor integration and overactivity of the somatosensory cortex have been demonstrated in dystonia. This study investigated the immediate after effect of an inhibitory repetitive transcranial magnetic stimulation (rTMS) applied over the somatosensory cortex on the writing function in WD patients with hand dystonia. We performed a pilot prospective randomized double-blind sham-controlled crossover rTMS study...
July 8, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28687447/repetitive-transcranial-magnetic-stimulation-of-the-supplementary-motor-area-in-treatment-resistant-obsessive-compulsive-disorder-an-open-label-pilot-study
#7
Young-Ji Lee, Bon-Hoon Koo, Wan-Seok Seo, Hye-Geum Kim, Ji-Yean Kim, Eun-Jin Cheon
Obsessive-compulsive disorder (OCD) is a severely distressing disorder represented by obsessions and compulsions. A significant proportion of OCD patients fail to improve with conventional treatment methods. Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an alternative for OCD treatment. Functional neuroimaging studies indicate that OCD is associated with increased activity in the supplementary motor area (SMA), a region that plays an important role in the pathophysiology of this disorder...
July 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28666237/excitability-of-the-masseter-inhibitory-reflex-after-high-frequency-rtms-over-the-motor-cortex-a-study-in-healthy-humans
#8
Congcong Cui, Yuhan Song, Xiao Fan, Qian Guo, Jijun Wang, Weicai Liu
OBJECTIVE: We aimed to investigate the influence of high frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex on excitability of the masseter inhibitory reflex (MIR) in healthy subjects. Our goal in conducting this study was to obtain a better understanding of the subcortical and cortical networks related to the excitability of the central masticatory pathway. METHODS: Twenty healthy volunteers participated in this study. MIRs were evaluated both before and after high frequency rTMS to elicit motor evoked potentials (MEPs) using single- and double-shock techniques over the motor cortex...
June 17, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28652969/interindividual-differences-in-motor-network-connectivity-and-behavioral-response-to-itbs-in-stroke-patients
#9
Svenja Diekhoff-Krebs, Eva-Maria Pool, Anna-Sophia Sarfeld, Anne K Rehme, Simon B Eickhoff, Gereon R Fink, Christian Grefkes
Cerebral plasticity-inducing approaches like repetitive transcranial magnetic stimulation (rTMS) are of high interest in situations where reorganization of neural networks can be observed, e.g., after stroke. However, an increasing number of studies suggest that improvements in motor performance of the stroke-affected hand following modulation of primary motor cortex (M1) excitability by rTMS shows a high interindividual variability. We here tested the hypothesis that in stroke patients the interindividual variability of behavioral response to excitatory rTMS is related to interindividual differences in network connectivity of the stimulated region...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28642024/rtms-with-a-two-coil-array-safety-and-efficacy-for-treatment-resistant-major-depressive-disorder
#10
Linda L Carpenter, Scott T Aaronson, Gregory N Clarke, Paul E Holtzheimer, Clark W Johnson, William M McDonald, Elizabeth L Stannard, M Bret Schneider
BACKGROUND: Therapeutic repetitive Transcranial Magnetic Stimulation (rTMS) has emerged as a standard of care for individuals with major depressive disorder (MDD) who do not benefit from, or are unable to tolerate, antidepressant pharmacotherapy. Depth of stimulation is limited with currently approved figure-eight coils and larger coils capable of deeper penetration may be associated with loss of stimulation focality and undesired recruitment of motor cortex. A second generation 2-coil array rTMS system was designed to target converging brain pathways for potentially deeper prefrontal cortex stimulation...
June 9, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28638206/effect-of-repetitive-transcranial-magnetic-stimulation-on-cigarette-smoking-in-patients-with-schizophrenia
#11
Wanli Huang, Fang Shen, Jiangtao Zhang, Baoping Xing
BACKGROUND: The high smoking rate among patients with schizophrenia is an important public health problem, and researchers have been studying how to change the status quo. OBJECTIVE: We investigated the effects of high frequency (10Hz) repetitive transcranial magnetic stimulation on the amount of cigarette smoking in patients with schizophrenia. METHOD: This study enrolled 37 male patients with schizophrenia who were at a stable stage of treatment...
December 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28636582/bilateral-dmpfc-rtms-leads-to-sustained-remission-in-geriatric-treatment-resistant-depression-a-case-report
#12
David Sender, Bruno Palazzo Nazar, Tathiana Baczynski, Flávia Paes, Peter Fettes, Jonathan Downar, Carlos Campos, Antonio Egidio Nardi, Sergio Machado
No abstract text is available yet for this article.
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28633972/the-neural-basis-of-form-and-form-motion-integration-from-static-and-dynamic-translational-glass-patterns-a-rtms-investigation
#13
Andrea Pavan, Filippo Ghin, Rita Donato, Gianluca Campana, George Mather
A long-held view of the visual system is that form and motion are independently analysed. However, there is physiological and psychophysical evidence of early interaction in the processing of form and motion. In this study, we used a combination of Glass patterns (GPs) and repetitive Transcranial Magnetic Stimulation (rTMS) to investigate in human observers the neural mechanisms underlying form-motion integration. GPs consist of randomly distributed dot pairs (dipoles) that induce the percept of an oriented stimulus...
June 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28631869/lateralized-hippocampal-volume-increase-following-high-frequency-left-prefrontal-repetitive-transcranial-magnetic-stimulation-in-patients-with-major-depression
#14
Shunsuke Hayasaka, Motoaki Nakamura, Yoshihiro Noda, Takuji Izuno, Takashi Saeki, Hideo Iwanari, Yoshio Hirayasu
AIM: Repetitive transcranial magnetic stimulation (rTMS) has been applied as a treatment for patients with treatment-resistant depression in recent years, and a large body of evidence has demonstrated its therapeutic efficacy through stimulating neuronal plasticity. The aim of this study was to investigate structural alterations in the hippocampus (HIPP) and amygdala (AM) following conventional rTMS in patients with depression. METHODS: Twenty-eight patients with depression underwent 10 daily 20-Hz left prefrontal rTMS over 2 weeks...
June 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28629874/neural-activity-during-attentional-conflict-predicts-reduction-in-tinnitus-perception-following-rtms
#15
G A James, J D Thostenson, G Brown, G Carter, H Hayes, S P Tripathi, D J Dobry, R B Govindan, J L Dornhoffer, D K Williams, C D Kilts, M S Mennemeier
BACKGROUND: Subjective idiopathic tinnitus is an intrusive, distracting, and potentially disabling disorder characterized by phantom perception of sounds. Although tinnitus has no approved pharmacologic treatment, recent evidence supports the use of repetitive transcranial magnetic stimulation (rTMS) to alleviate tinnitus symptoms. OBJECTIVE/HYPOTHESIS: Repetitive TMS delivered over the middle superior temporal gyrus (STG) may alter ratings of tinnitus awareness and annoyance more than loudness due to change in attentional processing...
June 2, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28626318/the-effects-of-repetitive-transcranial-magnetic-stimulation-rtms-on-depression-visual-perception-and-activities-of-daily-living-in-stroke-patients
#16
Ko-Un Kim, Soo-Han Kim, Tae-Gyu An
[Purpose] The present study aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on visual perception, depression, and activities of daily livings (ADLs) in stroke patients. [Subjects and Methods] Forty-four stroke patients were divided equally into an experimental group that underwent rTMS and a control group that underwent mock rTMS. Changes in patient visual perception, depression, and ADLs were evaluated. All subjects underwent treatment for 20 minutes, 5 times per week, for 4 weeks...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28624361/low-intensity-rtms-has-sex-dependent-effects-on-the-local-response-of-glia-following-a-penetrating-cortical-stab-injury
#17
Darren Clarke, Marissa A Penrose, Alan R Harvey, Jennifer Rodger, Kristyn A Bates
Repetitive transcranial magnetic stimulation (rTMS), a non-invasive form of brain stimulation, has shown experimental and clinical efficacy in a range of neuromodulatory models, even when delivered at low intensity (i.e. subthreshold for action potential generation). After central nervous system (CNS) injury, studies suggest that reactive astrocytes and microglia can have detrimental but also beneficial effects; thus modulating glial activity, for example through application of rTMS, could potentially be a useful therapeutic tool following neurotrauma...
June 15, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28614492/clinical-improvement-in-patients-with-borderline-personality-disorder-after-treatment-with-repetitive-transcranial-magnetic-stimulation-preliminary-results
#18
Julian Reyes-López, Josefina Ricardo-Garcell, Gabriela Armas-Castañeda, María García-Anaya, Iván Arango-De Montis, Jorge J González-Olvera, Francisco Pellicer
Objective: Current treatment of borderline personality disorder (BPD) consists of psychotherapy and pharmacological interventions. However, the use of repetitive transcranial magnetic stimulation (rTMS) could be beneficial to improve some BPD symptoms. The objective of this study was to evaluate clinical improvement in patients with BPD after application of rTMS over the right or left dorsolateral prefrontal cortex (DLPFC). Method: Twenty-nine patients with BPD from the National Institute of Psychiatry, Mexico, were randomized in two groups to receive 15 sessions of rTMS applied over the right (1 Hz, n=15) or left (5 Hz, n=14) DLPFC...
June 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28614399/the-effects-of-high-frequency-rtms-over-the-left-dlpfc-on-cognitive-control-in-young-healthy-participants
#19
Yanmin Li, Lin Wang, Meng Jia, Jihong Guo, Huijun Wang, Mingwei Wang
A large body of evidence suggests that repetitive transcranial magnetic stimulation (rTMS) is clinically effective in treating neuropsychiatric disorders and multiple sessions are commonly used. However, it is unknown whether multiple sessions of rTMS improve cognitive control, which is a function of the neural circuitry of the left dorsolateral prefrontal cortex (DLPFC)-cingulate cortex in healthy individuals. In addition, it is still unclear which stages of neural processing are altered by rTMS. In this study, we investigated the effects of high-frequency rTMS on cognitive control and explored the time course changes of cognitive processing after rTMS using event-related potentials (ERPs)...
2017: PloS One
https://www.readbyqxmd.com/read/28612547/-treatment-of-unilateral-neglect-using-repetitive-transcranial-magnetic-stimulation-rtms-and-sensory-cueing-sc-in-stroke-patients
#20
Ren-Gang Zhang, Sha-Xin Liu, Feng-Yi Wang, Xi-Chao Ma, Yong-Hong Yang
OBJECTIVES: To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) and sensory cueing (SC) for improving hemi-spatial attention deficits related to unilateral neglect, upper limb function and independence of stroke patients. METHODS: An assessor-blinded randomized controlled trial (RCT) was conducted. Eligible stroke patients were treated with rTMS (n =17) or rTMS combined with SC (n =16) in addition to conventional rehabilitation measures...
March 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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