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https://www.readbyqxmd.com/read/28533148/repetitive-transcranial-magnetic-stimulation-of-the-right-dorsal-lateral-prefrontal-cortex-in-the-treatment-of-generalized-anxiety-disorder-a-randomized-double-blind-sham-controlled-clinical-trial
#1
Dancho Dilkov, Emily R Hawken, Emil Kaludiev, Roumen Milev
BACKGROUND: Up to 50% of people with GAD fail to respond to first-line pharmacotherapies for generalized anxiety disorder (GAD), partly due to poor treatment compliance rates and partly due to the complex physiology underlying GAD. Thus, new non-invasive techniques, like repetitive transcranial magnetic stimulation (rTMS) are being investigated. METHODS: Participants were recruited from two different mood disorder sites: Kingston, Ontario, Canada and Sofia, Bulgaria...
May 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28530089/use-of-low-frequency-repetitive-transcranial-magnetic-stimulation-to-reduce-context-dependent-learning-in-people-with-parkinson-s-disease
#2
Ya-Yun Lee, Beth E Fisher
BACKGROUND: Compared with age-matched non-disabled adults, people with Parkinson's disease (PD) demonstrated greater context-dependent learning, a phenomenon in which an individual shows inferior motor performance when the testing environmental context is different from the original practice context. Additionally, enhanced context- dependency has been shown to be associated with an increased activation of the dorsolateral prefrontal cortex (DLPFC). AIM: This study aimed to determine whether context-dependent learning in people with PD could be reduced by decreasing DLPFC activation with low frequency repetitive transcranial magnetic stimulation (rTMS)...
May 22, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28529174/inhibitory-rtms-of-secondary-somatosensory-cortex-reduces-intensity-but-not-pleasantness-of-gentle-touch
#3
Laura K Case, Claire M Laubacher, Emily A Richards, Primavera Spagnolo, Håkan Olausson, MCatherine Bushnell
Research suggests that the discriminative and affective aspects of touch are processed differently in the brain. Primary somatosensory cortex is strongly implicated in touch discrimination, whereas insular and prefronal regions have been associated with pleasantness aspects of touch. However, the role of secondary somatosensory cortex (S2) is less clear. In the current study we used inhibitory repetitive transcranial magnetic stimulation (rTMS) to temporarily deactivate S2 and probe its role in touch perception...
May 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28515709/effects-of-10-hz-repetitive-transcranial-magnetic-stimulation-of-the-left-dorsolateral-prefrontal-cortex-in-disorders-of-consciousness
#4
Xiaoyu Xia, Yang Bai, Yangzhong Zhou, Yi Yang, Ruxiang Xu, Xiaorong Gao, Xiaoli Li, Jianghong He
BACKGROUND: While repetitive transcranial magnetic stimulation (rTMS) has been applied in treatment of patients with disorders of consciousness (DOC), a standardized stimulation protocol has not been proposed, and its therapeutic effects are inconsistently documented. OBJECTIVES: To assess the efficacy of rTMS in improving consciousness in patients with persistent minimally conscious state (MCS) or unresponsive wakefulness syndrome (UWS), previously known as vegetative state (VS)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28496402/cortico-striatal-thalamic-loop-circuits-of-the-orbitofrontal-cortex-promising-therapeutic-targets-in-psychiatric-illness
#5
REVIEW
Peter Fettes, Laura Schulze, Jonathan Downar
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex human behaviors such as evaluation, affect regulation and reward-based decision-making. Importantly, the medial and lateral OFC (mOFC and lOFC) circuits have functionally and anatomically distinct connectivity profiles which differentially contribute to the various aspects of goal-directed behavior. OFC corticostriatal circuits have been consistently implicated across a wide range of psychiatric disorders, including major depressive disorder (MDD), obsessive compulsive disorder (OCD), and substance use disorders (SUDs)...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28493825/repetitive-transcranial-magnetic-stimulation-for-treatment-of-lactacystin-induced-parkinsonian-rat-model
#6
Maowen Ba, Guozhao Ma, Chao Ren, Xuwen Sun, Min Kong
The dysfunction of ubiquitin-proteasome system is an important pathogenesis in the neurodegenerative process of Parkinson's disease. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive and potential method in treating Parkinson's disease. To investigate whether rTMS has neuroprotective effects in parkinsonian rat model induced by ubiquitin-proteasome system impairment, we gave rTMS daily for 4 weeks to proteasome inhibitor, lactacystin-induced parkinsonian rat model. Rotational behavior test demonstrated that rTMS obviously reduced apomorphine-induced turning number in parkinsonian rats...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28493519/neurotransmitters-behind-pain-relief-with-transcranial-magnetic-stimulation-positron-emission-tomography-evidence-for-release-of-endogenous-opioids
#7
S Lamusuo, J Hirvonen, P Lindholm, I K Martikainen, N Hagelberg, R Parkkola, T Taiminen, J Hietala, S Helin, A Virtanen, A Pertovaara, S K Jääskeläinen
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) at M1/S1 cortex has been shown to alleviate neuropathic pain. OBJECTIVES: To investigate the possible neurobiological correlates of cortical neurostimulation for the pain relief. METHODS: We studied the effects of M1/S1 rTMS on nociception, brain dopamine D2 and μ-opioid receptors using a randomized, sham-controlled, double-blinded crossover study design and 3D-positron emission tomography (PET)...
May 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28493371/effects-of-repetitive-transcranial-magnetic-stimulation-on-improvement-of-cognition-in-elderly-patients-with-cognitive-impairment-a-systematic-review-and-meta-analysis
#8
REVIEW
Calvin Pak Wing Cheng, Corine Sau Man Wong, Kelsey Kimyin Lee, Alfred Pui Kam Chan, Jerry Wing Fai Yeung, Wai Chi Chan
OBJECTIVE: This systematic review and meta-analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment. METHODS: A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016...
May 11, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28484405/management-of-chronic-tinnitus-and-insomnia-with-repetitive-transcranial-magnetic-stimulation-and-cognitive-behavioral-therapy-a-combined-approach
#9
Kneginja Richter, Jens Acker, Lence Miloseva, Lukas Peter, Günter Niklewski
It has been estimated that up to 80% of people will experience symptoms of tinnitus over the courses of their lives, with rates of comorbid sleeping problems ranging from 50 to 77%. Because of a potential connection between tinnitus and sleep disorders as well as high rates of comorbid psychiatric disorders, interdisciplinary approaches to treatment seem to be the most efficient option. In this study, we present the case of a 53-year-old male patient, who started to experience symptoms of tinnitus at the age of 49, most likely caused by work-related stress...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28476213/reprint-of-using-neuroimaging-to-individualize-tms-treatment-for-depression-toward-a-new-paradigm-for-imaging-guided-intervention
#10
Bruce M Luber, Simon Davis, Elisabeth Bernhardt, Andrada Neacsiu, Lori Kwapil, Sarah H Lisanby, Timothy J Strauman
The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than state-of-the-science methods which incorporate fMRI-guided neuronavigation based on a specific model of neurocircuit dysfunction. In this review, we examine such a specific model drawn from regulatory focus theory, which postulates two brain/behavior systems, the promotion and prevention systems, underlying goal pursuit...
May 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28471721/comparison-of-treatment-outcomes-between-10-and-20-eeg-electrode-location-system-guided-and-neuronavigation-guided-repetitive-transcranial-magnetic-stimulation-in-chronic-tinnitus-patients-and-target-localization-in-the-asian-brain
#11
Tae-Soo Noh, Yoon-Chan Rah, Jeong Sug Kyong, June Sic Kim, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh, Chun Kee Chung, Myung-Whan Suh
OBJECTIVE: rTMS is a non-invasive method that applies a brief magnetic pulse to the cortex and is regarded as a possible therapeutic method for tinnitus control. However, it remains unclear whether the rTMS treatment effect would be the same in tinnitus patients receiving the 10-20 EEG-based target localization as in those receiving imaging-based neuronavigation target localization. METHODS: We compared the treatment outcome of the 10-20 EEG-guided rTMS (Group 1) with that of the neuronavigation-guided rTMS (Group 2)...
May 4, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28464421/low-frequency-rtms-of-the-unaffected-hemisphere-in-stroke-patients-a-systematic-review
#12
REVIEW
L Sebastianelli, V Versace, S Martignago, F Brigo, E Trinka, L Saltuari, R Nardone
The aim of this review was to summarize the evidence for the effectiveness of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) over the unaffected hemisphere in promoting functional recovery after stroke. We performed a systematic search of the studies using LF-rTMS over the contralesional hemisphere in stroke patients and reviewed the 67 identified articles. The studies have been gathered together according to the time interval that had elapsed between the stroke onset and the beginning of the rTMS treatment...
May 2, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28460314/abnormal-functional-connectivity-within-resting-state-networks-is-related-to-rtms-based-therapy-effects-of-treatment-resistant-depression-a-pilot-study
#13
Ruiyang Ge, Daniel M Blumberger, Jonathan Downar, Zafiris J Daskalakis, Adam A Dipinto, Joseph C W Tham, Raymond Lam, Fidel Vila-Rodriguez
BACKGROUND: Treatment resistant depression (TRD) remains a clinical challenge, and finding biomarkers that predict treatment response are a long sought goal to precisely indicate treatments. This pilot study aims to characterize brain dysfunction in TRD patients who underwent rTMS to define neuroimaging biomarkers that discriminate non-responders (NR) from responders (R). METHODS: 20 TRD patients who underwent a course of rTMS to the left DLPFC were categorized into R and NR groups based on a >50% reduction in HRSD scores...
April 26, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28454819/causal-role-of-the-posterior-parietal-cortex-for-two-digit-mental-subtraction-and-addition-a-repetitive-tms-study
#14
Maria Montefinese, Cristina Turco, Francesco Piccione, Carlo Semenza
Although parietal areas of the left hemisphere are known to be involved in simple mental calculation, the possible role of the homologue areas of the right hemisphere in mental complex calculation remains debated. In the present study, we tested the causal role of the posterior parietal cortex of both hemispheres in two-digit mental addition and subtraction by means of neuronavigated repetitive TMS (rTMS), investigating possible hemispheric asymmetries in specific parietal areas. In particular, we performed two rTMS experiments, which differed only for the target sites stimulated, on independent samples of participants...
April 26, 2017: NeuroImage
https://www.readbyqxmd.com/read/28442424/thioredoxin-is-not-a-marker-for-treatment-resistance-depression-but-associated-with-cognitive-function-an-rtms-study
#15
Efruz Pirdogan Aydın, Abdullah Genc, Mihriban Dalkıran, Ece Türkyilmaz Uyar, Ömer Akil Özer, Kayıhan Oğuz Karamustafalıoğlu
Elevated oxidative stress is known to play an important role in development of depression and cognitive dysfunction. To date, thioredoxin (TRX), an antioxidant protein, has been investigated as a marker for psychiatric disorders such as schizophrenia, bipolar disorder and autism but its relationship with depression is yet to be unknown. The aim of this study is to detect the TRX levels in patients with treatment-resistant depression (TRD), analyse the effect of rTMS (repetitive transcranial magnetic stimulation) application on TRX levels and display the relationship of TRX with cognitive areas...
April 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28442422/effects-of-low-frequency-rtms-treatment-on-brain-networks-for-inner-speech-in-patients-with-schizophrenia-and-auditory-verbal-hallucinations
#16
Leonie Bais, Edith Liemburg, Ans Vercammen, Richard Bruggeman, Rikus Knegtering, André Aleman
INTRODUCTION: Efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) targeting the temporo-parietal junction (TPJ) for the treatment of auditory verbal hallucinations (AVH) remains under debate. We assessed the influence of a 1Hz rTMS treatment on neural networks involved in a cognitive mechanism proposed to subserve AVH. METHODS: Patients with schizophrenia (N=24) experiencing medication-resistant AVH completed a 10-day 1Hz rTMS treatment. Participants were randomized to active stimulation of the left or bilateral TPJ, or sham stimulation...
April 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28441583/randomized-controlled-trial-of-repetitive-transcranial-magnetic-stimulation-combined-with-paroxetine-for-the-treatment-of-patients-with-first-episode-major-depressive-disorder
#17
Yu-Mei Wang, Ning Li, Lin-Lin Yang, Mei Song, Le Shi, Wen-Hao Chen, Su-Xia Li, Xue-Yi Wang, Lin Lu
Repetitive transcranial magnetic stimulation (rTMS) has been introduced as a new and effective treatment option for major depression. This paper examined the effectiveness of rTMS on first episode depressed patients when combined with antidepressant drugs. A random sample of forty-three first-episode depressed patients received active or sham rTMS to the left dorsolateral prefrontal cortex, and concomitantly took paroxetine for 4 weeks, and paroxetine monotherapy for 4 weeks afterwards. Response was defined as a ≥50% decrease on the total Hamilton Depression Rating Scale (HDRS) from the baseline, and remission was defined as an HDRS total residual score <8...
April 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28438543/modulation-of-motor-cortex-excitability-predicts-antidepressant-response-to-prefrontal-cortex-repetitive-transcranial-magnetic-stimulation
#18
Albino J Oliveira-Maia, Daniel Press, Alvaro Pascual-Leone
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) is a treatment option for patients with medication-resistant major depressive disorder (MDD). However, antidepressant response is variable and there are currently no response predictors with sufficient accuracy for clinical use. OBJECTIVE: We report on results of an observational open-label study to determine whether the modulatory effect of 10 Hz motor cortex (MC) rTMS is predictive of the antidepressant effect of 10 Hz DLPFC rTMS...
March 31, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28433830/spasticity-management-the-current-state-of-transcranial-neuromodulation
#19
REVIEW
Antonino Leo, Antonino Naro, Francesco Molonia, Provvidenza Tomasello, Ileana Saccà, Alessia Bramanti, Margherita Russo, Placido Bramanti, Angelo Quartarone, Rocco Salvatore Calabrò
This narrative review aims to provide an objective view of the noninvasive neuromodulation (NINM) protocols available for treating spasticity, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). On the basis of the relevant randomized controlled trials, we infer that NINM is more effective in reducing spasticity when combined with the conventional therapies than used as a stand-alone treatment. However, the magnitude of NINM after-effects depends significantly on the applied hemisphere and the underlying pathology...
April 20, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28428769/individualized-repetitive-transcranial-magnetic-stimulation-treatment-in-chronic-tinnitus
#20
Peter M Kreuzer, Timm B Poeppl, Rainer Rupprecht, Veronika Vielsmeier, Astrid Lehner, Berthold Langguth, Martin Schecklmann
BACKGROUND: Prefrontal and temporo-parietal repetitive transcranial magnetic stimulation (rTMS) in patients suffering from chronic tinnitus have shown significant but only moderate effectiveness with high interindividual variability in treatment response. This open-label pilot study was designed to examine the general feasibility of an individualized fronto-temporal rTMS protocol and to explore what criteria are needed for a more detailed evaluation in randomized clinical studies. METHODS: During the first session of a 2-week rTMS protocol, we applied different rTMS protocols to the left and right temporo-parietal and dorsolateral prefrontal cortex (DLPFC) in 25 tinnitus patients...
2017: Frontiers in Neurology
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