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https://www.readbyqxmd.com/read/28185686/outbreak-of-kpc-2-producing-enterobacteriaceae-caused-by-clonal-dissemination-of-klebsiella-pneumoniae-st307-carrying-an-incx3-type-plasmid-harboring-a-truncated-tn4401a
#1
Jung Ok Kim, Sae Am Song, Eun-Jeong Yoon, Jeong Hwan Shin, Hyukmin Lee, Seok Hoon Jeong, Kyungwon Lee
Over a 5-month period between the end of June and the beginning of November in 2015, a KPC-producing Enterobacteriaceae outbreak occurred in a general hospital in Busan, South Korea, being associated with a total of 50 clinical isolates from 47 patients. Multilocus sequence typing and pulsed-field gel electrophoresis were carried out for strain typing and whole-genome sequencing was performed to characterize the plasmids. A clonal spread of K. pneumoniae sequence type 307 (ST307) carrying a self-transferable IncX3-type plasmid harboring blaKPC-2 was responsible for the outbreak...
December 27, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28167556/the-importance-of-clonal-complex-258-and-incfk2-like-plasmids-among-a-global-collection-of-klebsiella-pneumoniae-with-blakpcs
#2
Gisele Peirano, Patricia A Bradford, Krystyna M Kazmierczak, Liang Chen, Barry N Kreiswirth, Johann D D Pitout
This study was designed to determine the global distribution of clonal complex (CC) 258 and IncFIIK2-like plasmids with blaKPC among 522 global KPC-producing K. pneumoniae CC258 (i.e. ST258 [clades I and II], ST11, ST512) and ST147 were statistically associated with IncFIIK2-like KPC-containing plasmids and may possess an epidemiological advantage over isolates that harboured non-IncF KPC-harboring plasmids.
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28152085/a-putative-multi-replicon-plasmid-co-harboring-beta-lactamase-genes-blakpc-2-blactx-m-14-and-blatem-1-and-trimethoprim-resistance-gene-dfra25-from-a-klebsiella-pneumoniae-sequence-type-st-11-strain-in-china
#3
Yu Tang, Pinghua Shen, Wei Liang, Jialin Jin, Xiaofei Jiang
The global emergence of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae poses a major public health threat requiring immediate and aggressive action. Some older generation antibiotics, such as trimethoprim, serve as alternatives for treatment of infections. Here, we determined the complete nucleotide sequence of plasmid pHS091147, which co-harbored the carbapenemase (blaKPC-2) and trimethoprim resistance genes (dfrA25) from a Klebsiella pneumoniae sequence type (ST) 11 clone recovered in Shanghai, China...
2017: PloS One
https://www.readbyqxmd.com/read/28137818/the-population-of-carbapenemase-producing-klebsiella-pneumoniae-is-distinct-and-more-clonal-than-the-carbapenem-susceptible-population
#4
Andrés Esteban-Cantos, Belén Aracil, Verónica Bautista, Adriana Ortega, Noelia Lara, David Saez, Sara Fernández-Romero, María Pérez-Vázquez, Ferran Navarro, Hajo Grundmann, José Campos, Jesús Oteo
We study in parallel the population structure of 90 carbapenemase-producing and 88 carbapenemase-susceptible Klebsiella pneumoniae isolated in 20 Spanish hospitals, in the context of the EuSCAPE project. Fourteen and 50 MLST sequence types (STs) were detected among the carbapenemase-producing and carbapenem-susceptible isolates, respectively. ST11 and ST15 clones were more frequent in the carbapenemase-producing than in the carbapenemase-susceptible group (P<0.0001). Among carbapenem-suceptible group, the cefotaxime-resistant population showed population parameters studied between wildtype- and carbapenemase-producers populations...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28111326/molecular-characterisations-of-integrons-in-clinical-isolates-of-klebsiella-pneumoniae-in-a-chinese-tertiary-hospital
#5
Xuan Xu, Xuan Li, Mei Luo, Pin Liu, Kewen Su, Ying Qing, Shuai Chen, Jingfu Qiu, Yingli Li
BACKGROUND: Integrons are mobile genetic elements that play an important role in the distribution of antibiotic-resistance genes among bacteria. This study aimed to investigate the distribution of integrons in clinical isolates of Klebsiella pneumoniae and explore the molecular mechanism of integron-mediated multiple-drug resistance in K. pneumoniae. METHODS: Class 1, 2, and 3 integrases were identified by polymerase chain reaction (PCR) among 178 K. pneumoniae clinical isolates...
January 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28098538/neisseria-meningitidis-st11-complex-isolates-associated-with-nongonococcal-urethritis-indiana-usa-2015-2016
#6
Evelyn Toh, Dharanesh Gangaiah, Byron E Batteiger, James A Williams, Janet N Arno, Albert Tai, Teresa A Batteiger, David E Nelson
At a clinic in Indianapolis, Indiana, USA, we observed an increase in Neisseria gonorrhoeae-negative men with suspected gonococcal urethritis who had urethral cultures positive for N. meningitidis. We describe genomes of 2 of these N. meningitidis sequence type 11 complex urethritis isolates. Clinical evidence suggests these isolates may represent an emerging urethrotropic clade.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28072891/molecular-epidemiology-and-resistome-analysis-of-multidrug-resistant-st11-klebsiella-pneumoniae-strain-containing-multiple-copies-of-extended-spectrum-%C3%AE-lactamase-genes-using-whole-genome-sequencing
#7
Roshan DSouza, Naina Adren Pinto, Insik Hwang, Hwang Younjee, YoungLag Cho, Hyunsoo Kim, Dongeun Yong, Jongrak Choi, Kyungwon Lee, Yunsop Chong
The aim of this work was to investigate the mechanism responsible for multidrug resistance in ST11 Klebsiella pneumoniae YMC 2013/7/B3993 containing multiple copies of ESBL genes using multiple parallel sequencing technology. In-depth analysis of the strain revealed multiple copies of ESBL genes, 2 copies of blaSHV-12 and 1 copy of blaCTX-M-15. Furthermore, 1 copy of blaOXA-9 and 3 copies of blaTEM-1 were found. The insertion of Tn1331 was detected, which consisted of blaOXA-9, blaTEM-1, aac(6')-lb-cr, and aadA1 genes...
January 2017: New Microbiologica
https://www.readbyqxmd.com/read/28043219/rise-in-invasive-serogroup-w-meningococcal-disease-in-australia-2013-2015
#8
Nicolee V Martin, Katherine S Ong, Benjamin P Howden, Monica M Lahra, Stephen B Lambert, Frank H Beard, Gary K Dowse, Nathan Saul
Since 2013, there has been an increase in the number of notified cases of invasive meningococcal disease (IMD) due to serogroup W (MenW) in Australia. In response to this observed increase, the Communicable Diseases Network Australia convened a working group in 2015 to collate and analyse the epidemiology of MenW disease nationally. Enhanced surveillance data collected by jurisdictions were collated and analysed, and whole genome sequencing (WGS) of MenW isolates assessed the genomic relatedness of strains between 2012 and 2015...
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28031204/chromosomal-integration-of-the-klebsiella-pneumoniae-carbapenemase-gene-blakpc-in-klebsiella-species-elusive-but-not-rare
#9
Amy J Mathers, Nicole Stoesser, Weidong Chai, Joanne Carroll, Katie Barry, Anita Cherunvanky, Robert Sebra, Andrew Kasarskis, Tim E Peto, A Sarah Walker, Costi D Sifri, Derrick W Crook, Anna E Sheppard
Carbapenemase genes in Enterobacteriaceae are mostly described as being plasmid-associated. However, the genetic context of carbapenemase genes is not always confirmed in epidemiological surveys, and the frequency of their chromosomal integration is therefore unknown.A previously sequenced collection of blaKPC-positive Enterobacteriaceae from a single US institution (2007-2012; n=281 isolates, 182 patients) was analyzed to identify chromosomal insertions of Tn4401, the transposon most frequently harboring blaKPC Using a combination of short- and long-read sequencing, we confirmed five independent chromosomal integration events from 6/182 (3%) patients, corresponding to 15/281 (5%) isolates...
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27939808/first-report-of-ndm-1-producing-klebsiella-pneumoniae-imported-from-africa-to-italy-evidence-of-the-need-for-continuous-surveillance
#10
Luigi Principe, Carola Mauri, Viola Conte, Beatrice Pini, Tommaso Giani, Gian Maria Rossolini, Francesco Luzzaro
OBJECTIVES: NDM-producing Enterobacteriaceae are considered emergent on the African continent and have been increasingly reported in recent years. In contrast, strains producing NDM-type enzymes have been rarely reported in Italy, usually associated with sporadic cases or small outbreaks. Here we report two cases of infection caused by NDM-1-producing Klebsiella pneumoniae (NDM-KP) in two unrelated patients returned from travel to Egypt. CASE REPORTS: The two patients had been previously hospitalised for a short period in two different Egyptian hospitals...
December 5, 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27873547/daily-ingestion-of-the-probiotic-lactobacillus-paracasei-st11-decreases-vaccinia-virus-dissemination-and-lethality-in-a-mouse-model
#11
A C Dos Santos Pereira Andrade, M Teixeira Lima, G Pereira Oliveira, R Silva Calixto, É Lorenna de Sales E Souza, D da Glória de Souza, C M de Almeida Leite, J M Siqueira Ferreira, E G Kroon, D Bretas de Oliveira, F Dos Santos Martins, J S Abrahão
Vaccinia virus (VACV) is an important pathogen. Although studies have shown relationships between probiotics and viruses, the effect of probiotics on VACV infection is unknown. Therefore, this work aims to investigate the probiotics effects on VACV infection. Mice were divided into four groups, two non-infected groups, one receiving the probiotic, the other one not receiving it, and two groups infected intranasally with VACV Western Reserve (VACV-WR) receiving or not receiving the probiotic. Viral titres in organs and cytokine production in the lungs were analysed...
November 22, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27866753/-molecular-epidemiology-of-carbapenemase-producing-enterobacteriaceae-infection-colonisation-in-a-hospital-in-madrid
#12
Patricia Brañas, Marta Gil, Jennifer Villa, María Ángeles Orellana, Fernando Chaves
INTRODUCTION: A description is presented on the molecular epidemiology of carbapenemase-producing enterobacteriaceae infection in a tertiary hospital. MATERIAL AND METHODS: A study was made on all the carbapenemase-producing enterobacteriaceae isolations obtained between February 2015 and March 2016 in the Hospital Universitario 12 de Octubre (Madrid). Phenotypic and molecular methods were used. RESULTS: A total of 7 bacterial species were identified, with the majority being Klebsiella pneumoniae (K...
November 17, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27800493/prevalence-and-characteristics-of-salmonella-isolated-from-free-range-chickens-in-shandong-province-china
#13
Xiaonan Zhao, Yanxia Gao, Chaoqun Ye, Lingling Yang, Tao Wang, Weishan Chang
Compared with chickens raised in intensively managed breeding farms, free-range chickens in China are quite popular due to lower breeding density and less antibiotics usage. However, investigations about Salmonella enterica from free-range chickens are quite rare. The aim of the present study was to investigate prevalence and characteristics of Salmonella in free-range chickens in Shandong province, China. During the period of August and November 2015, 300 fresh fecal swabs from different broilers in three free-range chicken farms (100 samples per farm) were collected to isolate Salmonella, and then these isolates were subjected to serotyping, antibiotic sensitivity testing, enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR), and multilocus sequence typing (ST)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27788691/outbreak-of-kpc-3-producing-st15-and-st348-klebsiella-pneumoniae-in-a-portuguese-hospital
#14
D Vubil, R Figueiredo, T Reis, C Canha, L Boaventura, G J DA Silva
To date, only a few sporadic cases of infections due to Klebsiella pneumoniae carbapenemase (KPC) producers have been reported in Portugal. Here, we report for the first time an outbreak of K. pneumoniae KPC-3 producers in a tertiary-care hospital during 2013. Twenty-seven ertapenem-resistant K. pneumoniae were identified in patients at a tertiary-care hospital during 2013 isolated predominantly from urine (48·1%) and blood (25·9%) cultures. All isolates were highly resistant to β-lactam antibiotics and most showed intermediate resistance to imipenem...
February 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/27779809/long-term-safety-and-efficacy-of-perinatal-probiotic-intervention-evidence-from-a-follow-up-study-of-four-randomized-double-blind-placebo-controlled-trials
#15
Krista Lundelin, Tuija Poussa, Seppo Salminen, Erika Isolauri
BACKGROUND: Societies worldwide are faced with a progressive increase in immune-mediated health problems such as allergic, autoimmune, and inflammatory diseases, as well as obesity. Perinatal administration of specific probiotic bacteria is an attractive approach in reducing the risk of these conditions, but long-term efficacy and safety data are lacking. The aim here was to evaluate the clinical benefit and long-term safety of specific probiotics administered during the perinatal period...
October 25, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27765412/characterisation-of-fosfomycin-resistance-mechanisms-and-molecular-epidemiology-in-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae-isolates
#16
Po-Liang Lu, Ya-Ju Hsieh, Jun-En Lin, Jun-Wei Huang, Tsung-Ying Yang, Lin Lin, Sung-Pin Tseng
Although fosfomycin is a treatment option for infections caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, fosfomycin resistance has been documented. To our knowledge, fosfomycin resistance mechanisms in Klebsiella pneumoniae have not been systematically investigated. A total of 108 ESBL-producing K. pneumoniae isolates collected from Kaohsiung Medical University Hospital, Taiwan, from August 2012 to May 2013 were analysed in this study. Pulsed-field gel electrophoresis (PFGE) revealed 64 pulsotypes and six non-typeable isolates, indicating high genetic diversity...
November 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27754776/first-description-of-kpc-2-producing-escherichia-coli-and-st15-oxa-48-positive-klebsiella-pneumoniae-in-tunisia
#17
Farah Ben Tanfous, Carla Andrea Alonso, Wafa Achour, Laura Ruiz-Ripa, Carmen Torres, Assia Ben Hassen
The aim of this study was to investigate the molecular features among Klebsiella pneumoniae and Escherichia coli strains showing a resistant/intermediate-resistant phenotype to ertapenem (R/IR-ERT), implicated in colonization/infection in patients of the Hematology and Graft Units of the National Bone Marrow Transplant Center of Tunisia (3-year period, 2011-2014). The major carbapenemase, extended-spectrum beta-lactamase, and plasmidic AmpC beta-lactamase genes were analyzed and characterized by PCR and sequencing...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27733128/nosocomial-outbreak-of-kpc-2-and-ndm-1-producing-klebsiella-pneumoniae-in-a-neonatal-ward-a-retrospective-study
#18
Jing Yu, Kun Tan, Zhihui Rong, Yue Wang, Zhongju Chen, Xuhui Zhu, Li Wu, Li Tan, Wei Xiong, Ziyong Sun, Ling Chen
BACKGROUND: The spread of resistance to carbapenems among Enterobacteriaceae has become a major public health problem in recent years. In this study, we describe an outbreak of Klebsiella pneumoniae in the neonatal ward. First, we aimed to study the drug resistance, genetic relatedness, and transmission mechanism of carbapenem-resistant K. pneumoniae; second, we implemented infection control measures to contain the outbreak. METHODS: We investigated 27 non-repetitive strains isolated from neonates and five strains cultured from around the neonatal ward...
October 12, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27685838/national-survey-of-colistin-resistance-among-carbapenemase-producing-enterobacteriaceae-and-outbreak-caused-by-colistin-resistant-oxa-48-producing-klebsiella-pneumoniae-france-2014
#19
Aurélie Jayol, Laurent Poirel, Laurent Dortet, Patrice Nordmann
From January 2014 to December 2014, 972 consecutive non-replicate carbapenemase-producing Enterobacteriaceae isolates from colonised or infected patients were collected at the Associated French National Reference Centre as part of the French national survey on antimicrobial resistance. It included 577 Klebsiella spp. (59%), 236 Escherichia coli (24%), 108 Enterobacter spp. (11%), 50 Citrobacter spp. (5%), and a single Salmonella spp. isolate (0.1%). Of 561 K. pneumoniae isolates, 35 were found to be resistant to colistin (6...
September 15, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27580572/antimicrobial-susceptibility-and-molecular-epidemiology-of-multidrug-resistant-klebsiella-pneumoniae-in-central-china
#20
Xiaobing Guo, Zaiqiu Cao, Zhifeng Dai, Yuan Li, Xiaohong He, Xiaoxin Hu, Fuyun Tian, Yihui Ren
Extended-spectrum-beta-lactamase-producing and carbapenemase-producing Klebsiella pneumoniae has rapidly spread through clinical units worldwide. This study investigated the epidemiology and resistance profiles of K. pneumoniae strains isolated in Central China between 2009 and 2014. Antimicrobial susceptibility tests and polymerase chain reaction were used to investigate the prevalence and resistance of ESBLs and carbapenemases produced by K. pneumoniae, and the prevalence of KPC-producing K. pneumoniae was investigated by multilocus sequence typing...
August 31, 2016: Japanese Journal of Infectious Diseases
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