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Arsenic

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https://www.readbyqxmd.com/read/28922726/chronic-arsenicosis-and-cadmium-exposure-in-wild-snowshoe-hares-lepus-americanus-breeding-near-yellowknife-northwest-territories-canada-part-2-manifestation-of-bone-abnormalities-and-osteoporosis
#1
S Amuno, A Al Kaissi, A Jamwal, S Niyogi, C E Quenneville
Various bone abnormalities, including osteoporosis, have been associated with chronic arsenic and cadmium exposure in experimental animal models, but information regarding the bone pathology of wild population of small mammals breeding in contaminated environment is limited. This present study was conducted to comparatively assess the prevalence and pattern of skeletal abnormalities in free ranging snowshoe hares inhabiting an area heavily contaminated by arsenic and other trace metals, near the vicinity of the abandoned Giant mine, and in a reference location approximately 20km from the city of Yellowknife, Northwest Territories, Canada...
September 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28920151/removal-of-arsenic-iii-and-v-from-laboratory-solutions-and-contaminated-groundwater-by-metallurgical-slag-through-anion-induced-precipitation
#2
Rafael Schouwenaars, Claudia Victoria Montoya-Bautista, Elizabeth Diane Isaacs-Páez, Myriam Solís-López, Rosa María Ramírez-Zamora
Metallurgical slag was used for the simultaneous removal of high concentrations of arsenite and arsenate from laboratory solutions and severely contaminated groundwater. Apart from demonstrating the high efficiency of arsenic removal in presence of competing species, the work aims to explore the physicochemical mechanisms of the process by means of microscopy observation and a detailed statistical analysis of existing kinetic and isotherm equations. Fitting was performed by non-linear least squares using weighted residuals; ANOVA and bootstrap methods were used to compare the models...
September 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28919425/detection-of-oligonucleotides-by-pna-peptide-conjugates-recognizing-the-biarsenical-fluoresceine-complex-flash-edt2
#3
Linda Piras, Concetta Avitabile, Luca Domenico D'Andrea, Michele Saviano, Alessandra Romanelli
We report the application of the arsenical complex FlAsH-EDT2 for the identification of oligonucleotide sequences. We designed PNA sequences conjugated to either a tetracysteine motif and to split tetracysteine sequences, that are recognized by FlAsH. The effect of conjugation of the PNA to the tetracysteine peptide and RNA hybridization on the fluorescence of the arsenical complex has been investigated. The reconstitution of the tetracysteine motif, starting from 15-mer PNAs conjugated to split tetracysteine sequences and hybridized to a complementary oligonucleotide was also explored...
September 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28918290/in-situ-arsenic-oxidation-and-sorption-by-a-fe-mn-binary-oxide-waste-in-soil
#4
Clare M McCann, Caroline L Peacock, Karen A Hudson-Edwards, Thomas Shrimpton, Neil D Gray, Karen L Johnson
The ability of a Fe-Mn binary oxide waste to adsorb arsenic (As) in a historically contaminated soil was investigated. Initial laboratory sorption experiments indicated that arsenite [As(III)] was oxidized to arsenate [As(V)] by the Mn oxide component, with concurrent As(V) sorption to the Fe oxide. The binary oxide waste had As(III) and As(V) adsorption capacities of 70mgg(-1) and 32mgg(-1) respectively. X-ray Absorption Near-Edge Structure and Extended X-ray Absorption Fine Structure at the As K-edge confirmed that all binary oxide waste surface complexes were As(V) sorbed by mononuclear bidentate corner-sharing, with 2 Fe at ∼3...
September 14, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28918278/heavy-metals-as-hg-and-v-and-stable-isotope-ratios-%C3%AE-13-c-and-%C3%AE-15-n-in-fish-from-yellow-river-estuary-china
#5
Yuan Liu, Guijian Liu, Zijiao Yuan, Houqi Liu, Paul K S Lam
The Yellow River Estuary is a significant fishery, but at present there are few studies about the concentrations of arsenic (As), mercury (Hg) and vanadium (V) in fish from this area, which might cause potential health risk to fish consumers. The aim of this study was to research on the accumulation and potential sources of heavy metals in the fish of the Yellow River Estuary. Arsenic, Hg, V and stable isotope ratios (δ(15)N and δ(13)C) in 11 species of 129 fish were analyzed. Results showed that the concentrations of As and Hg were all lower than the guideline levels established by international organizations and legal limits by several countries...
September 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28917711/crocodiles-and-alligators-antiamoebic-and-antitumor-compounds-of-crocodiles
#6
Ruqaiyyah Siddiqui, Shareni Jeyamogan, Salwa Mansoor Ali, Fatima Abbas, K A Sagathevan, Naveed Ahmed Khan
Crocodiles exist in unsanitary environments, feed on rotten meat, are often exposed to heavy metals such as arsenic, cadmium, cobalt, chromium, mercury, nickel, lead, selenium, tolerate high levels of radiation, and are amid the very few species to survive the catastrophic Cretaceous-Tertiary extinction event, nonetheless they can live for up to a 100 years. Moreover, as they live in unhygienic conditions, they regularly come across pathogens. Logically, we postulate that crocodiles have established mechanisms to defend themselves from noxious agents as well as protecting themselves from pathogens...
September 13, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28915699/biological-effects-and-epidemiological-consequences-of-arsenic-exposure-and-reagents-that-can-ameliorate-arsenic-damage-in-vivo
#7
REVIEW
Chinthalapally V Rao, Sanya Pal, Altaf Mohammed, Mudassir Farooqui, Mark P Doescher, Adam S Asch, Hiroshi Y Yamada
Through contaminated diet, water, and other forms of environmental exposure, arsenic affects human health. There are many U.S. and worldwide "hot spots" where the arsenic level in public water exceeds the maximum exposure limit. The biological effects of chronic arsenic exposure include generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage, epigenetic DNA modification, induction of genomic instability, and inflammation and immunomodulation, all of which can initiate carcinogenesis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914824/use-of-principal-components-analysis-and-kriging-to-predict-groundwater-sourced-rural-drinking-water-quality-in-saskatchewan
#8
Lianne McLeod, Lalita Bharadwaj, Tasha Epp, Cheryl L Waldner
Groundwater drinking water supply surveillance data were accessed to summarize water quality delivered as public and private water supplies in southern Saskatchewan as part of an exposure assessment for epidemiologic analyses of associations between water quality and type 2 diabetes or cardiovascular disease. Arsenic in drinking water has been linked to a variety of chronic diseases and previous studies have identified multiple wells with arsenic above the drinking water standard of 0.01 mg/L; therefore, arsenic concentrations were of specific interest...
September 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28914342/quantification-of-the-intracellular-life-time-of-water-molecules-to-measure-transport-rates-of-human-aquaglyceroporins
#9
Madelene Palmgren, Malin Hernebring, Stefanie Eriksson, Karin Elbing, Cecilia Geijer, Samo Lasič, Peter Dahl, Jesper S Hansen, Daniel Topgaard, Karin Lindkvist-Petersson
Orthodox aquaporins are transmembrane channel proteins that facilitate rapid diffusion of water, while aquaglyceroporins facilitate the diffusion of small uncharged molecules such as glycerol and arsenic trioxide. Aquaglyceroporins play important roles in human physiology, in particular for glycerol metabolism and arsenic detoxification. We have developed a unique system applying the strain of the yeast Pichia pastoris, where the endogenous aquaporins/aquaglyceroporins have been removed and human aquaglyceroporins AQP3, AQP7, and AQP9 are recombinantly expressed enabling comparative permeability measurements between the expressed proteins...
September 15, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28914181/remediation-approach-for-organic-compounds-and-arsenic-co-contaminated-soil-using-pressurized-hot-water-extraction-process
#10
Mohammad Nazrul Islam, Young-Tae Jo, Yeon-Jae Jeong, Jeong-Hun Park
Successful remediation of soil with co-existing organics contaminants and arsenic (As) is a challenge as the chemical and remediation technologies are different for each group of pollutants. In this study, the treatment effectiveness of pressurized hot water (PHW) extraction process was investigated for remediation of soil co-contaminated with phenol, crude oil, polycyclic aromatic hydrocarbons (PAHs) and As. An elimination percentage of about 99% was achieved for phenol, and in the range of 63-100% was observed for the PAHs at 260 °C for 90 min operation...
September 15, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28912556/synthesis-and-in-vitro-anticancer-evaluation-of-polyarsenicals-related-to-the-marine-sponge-derived-arsenicin-a
#11
Ines Mancini, Matteo Planchestainer, Andrea Defant
In the light of the promising bioactivity of the tetraarsenic marine metabolite arsenicin A, the dimethyl analogue 2 and four isomeric methylene homologues (including the natural product itself) were obtained using a one-pot microwave-assisted synthesis, starting from arsenic (III) oxide. Due to the poor diagnostic value of the NMR technique in the structural elucidation of these molecules, they were fully characterized by mass spectrometry and infrared (IR)-spectroscopy, comparing density functional theory (DFT) simulated and experimental spectra...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911658/identification-of-an-exposure-risk-to-heavy-metals-from-pharmaceutical-grade-rubber-stoppers
#12
Xianghui Li, Pingping Qian
Exposure to low concentrations of heavy metals and metalloids represents a well-documented risk to animal and human health. However, current standards (European Pharmacopeia [EP], United States Pharmacopoeia [USP], International Organization for Standardization [ISO], YBB concerned with rubber closures) only require testing for Zn in pharmaceutical-grade rubber stoppers and then using only pure water as a solvent. We extracted and quantified heavy metals and trace elements from pharmaceutical-grade rubber stoppers under conditions that might occur during the preparation of drugs...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910615/-beginning-with-the-smallest-intake-children-s-brain-development-and-the-role-of-neuroscience-in-global-environmental-health
#13
Kam Sripada
Early exposure to environmental toxins like lead, air pollution, and arsenic can have long-lasting and irreversible consequences for children's neurodevelopment, especially in the developing world. Though the number of pollutants increases each year, some neuroscientists are forging partnerships to improve measurement, raise awareness, and promote global health.
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28910252/lifetime-excess-cancer-risk-due-to-carcinogens-in-food-and-beverages-urban-versus-rural-differences-in-canada
#14
Roslyn Cheasley, C Peter Keller, Eleanor Setton
OBJECTIVES: To explore differences in urban versus rural lifetime excess risk of cancer from five specific contaminants found in food and beverages. METHODS: Probable contaminant intake is estimated using Monte Carlo simulations of contaminant concentrations in combination with dietary patterns. Contaminant concentrations for arsenic, benzene, lead, polychlorinated biphenyls (PCBs) and tetrachloroethylene (PERC) were derived from government dietary studies. The dietary patterns of 34 944 Canadians from 10 provinces were available from Health Canada's Canadian Community Health Survey, Cycle 2...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28905217/early-life-arsenic-exposure-infant-and-child-growth-and-morbidity-a-systematic-review
#15
REVIEW
Anisur Rahman, Caroline Granberg, Lars-Åke Persson
Epidemiological studies have suggested a negative association between early life arsenic exposure and fetal size at birth, and subsequently with child morbidity and growth. However, our understanding of the relationship between arsenic exposure and morbidity and growth is limited. This paper aims to systematically review original human studies with an analytical epidemiological study design that have assessed arsenic exposure in fetal life or early childhood and evaluated the association with one or several of the following outcomes: fetal growth, birth weight or other birth anthropometry, infant and child growth, infectious disease morbidity in infancy and early childhood...
September 14, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28904445/epidemiology-of-peripheral-neuropathy-an-indian-perspective
#16
REVIEW
Sweety Trivedi, Alak Pandit, Goutam Ganguly, Shyamal Kumar Das
Peripheral neuropathy (PN) is a common disorder and presents as diagnostic and therapeutic challenge to physicians and neurologists. In epidemiological studies from India from various regions the overall prevalence of PN varied from 5 to 2400 per 10,000 population in various community studies. India is composed of a multiethnic, multicultural population who are exposed to different adverse environmental factors such as arsenic and lead. Use of different chemotherapeutic agents with propensity to affect peripheral nerves, increasing methods of diagnosis of connective tissue disorders and use of immunomodulating drugs, growing aging population is expected to change the spectrum and burden of peripheral neuropathy in the community...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28904414/identification-of-arsenic-resistance-genes-from-marine-sediment-metagenome
#17
Nar Singh Chauhan, Sonam Nain, Rakesh Sharma
A metagenomic library of sea sediment metagenome containing 245,000 recombinant clones representing ~ 2.45 Gb of sea sediment microbial DNA was constructed. Two unique arsenic resistance clones, A7 and A12, were identified by selection on sodium arsenite containing medium. Clone A7 showed a six-fold higher resistance to arsenate [As(V)], a three-fold higher resistance to arsenite [As(III)] and significantly increased resistance to antimony [Sb(III)], while clone A12 showed increased resistance only to sodium arsenite and not to the other two metalloids...
September 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28903487/from-the-cover-arsenic-induces-hippocampal-neuronal-apoptosis-and-cognitive-impairments-via-an-up-regulated-bmp2-smad-dependent-reduced-bdnf-trkb-signaling-in-rats
#18
Rukmani Pandey, Vipin Rai, Juhi Mishra, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhyay
Arsenic promotes hippocampal neuronal damage inducing cognitive impairments. However, mechanism arbitrating arsenic-mediated cognitive deficits remains less-known. Here, we identified that chronic exposure to environmentally relevant doses of arsenic increased apoptosis, characterized by caspase-3 activation, poly(ADP-ribose) polymerase cleavage and Terminal deoxynucleotidyl transferase dUTP nick-end labeling of rat hippocampal neurons, marked by NeuN. Investigating apoptotic mechanism through invivo and invitro studies revealed that arsenic promoted bone morphogenetic protein-2 (BMP2) expression, supported by increased BMP-receptor2 (BMPR2) and p-Smad1/5 in hippocampal neurons...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28903143/arsenic-in-dermatology-from-dermatologic-therapy-to-carcinogen
#19
Connie R Shi, Vinod E Nambudiri
No abstract text is available yet for this article.
September 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28901456/the-antitumor-effects-of-arsenic-trioxide-in-mantle-cell-lymphoma-via-targeting-wnt-%C3%AE-%C3%A2-catenin-pathway-and-dna-methyltransferase-1
#20
Xin-Yu Li, Ying Li, Lingyan Zhang, Xin Liu, Lili Feng, Xin Wang
Mantle cell lymphoma (MCL) is an aggressive non‑Hodgkin lymphoma (NHL) with poor prognosis. The rapid progression and frequently relapse make it urgent to identify therapeutic agents with potent antitumor effect. Increasing evidence indicated that dysregulation of Wnt/β‑catenin pathway and abnormal methylation appeared to promote tumorigenesis. Arsenic trioxide (As2O3, ATO) has been reported effective in many hematologic malignancies in recent studies, however, the mechanism and effects of ATO in MCL still need further research...
September 7, 2017: Oncology Reports
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