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Arsenic

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https://www.readbyqxmd.com/read/29350772/arsenite-induced-histone-h3-modification-and-its-effects-on-egr1-and-fos-expression-in-hela-cells
#1
Toshihide Suzuki, Hiroshi Watanabe, Kayoko Kita, Taro Honma, Takafumi Ochi
It is evident that trivalent arsenicals do not have mutagenicity, but they are human carcinogens. Recently, epigenetic modification has been considered as one of the important causes of arsenical carcinogenicity. Here we examined global histone H3 modification by trivalent inorganic arsenite (iAs(III)) and its contribution to gene expression in HeLa cells. iAs(III) induced histone H3K9 dimethylation (H3K9me2) and trimethylation (H3K9me3), histone H3S10 phosphorylation (H3S10p), histone H3T11 phosphorylation (H3T11p) and histone H3K9S10 trimethyl-phosphorylation (H3K9me3S10p)...
January 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29350532/design-of-exceptionally-strong-organic-superbases-based-on-aromatic-pnictogen-oxides-a-computational-dft-analysis-of-the-oxygen-basicity-in-the-gas-phase-and-acetonitrile-solution
#2
Tana Tandaric, Robert Vianello
DFT B3LYP calculations convincingly showed that aromatic pnictogen-oxides offer scaffolds suitable for tailoring powerful organic superbases exhibiting exceptional oxygen basicity in both gas-phase and polar aprotic acetonitrile solution. With their protonation enthalpies and pKa values, they surpass the basicity of classical proton sponges and related nitrogen bases. The most potent system is provided with two arsenic-oxide moieties on the phenanthrene framework assisted with the two phosphazeno groups in the para-position to both basic centers...
January 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29349863/experimental-observation-of-thermally-excited-triplet-states-of-heavier-group-15-element-centered-diradical-dianions
#3
Yong Fang, Li Zhang, Cheng Cheng, Yue Zhao, Manabu Abe, Gengwen Tan, Xinping Wang
One-electron reductions of Mes*As=Fl* (1; Fl* = 2,7-di-tert-butylfluorenylidene, Mes* = 2,4,6-tBu3C6H2) and diarsaalkenes [1,2-b]-IF(=AsMes*)2 (2; IF = indenofluorene) with potassium led to the isolation of the arsenic-centered radical anion salts 1K and 2K, respectively. The diradical dianion salts 2K2 and 3K2 were afforded by the reduction of 2 and 2,8-tBu2-[2,1-b]-IF(=AsMes*)2 (3) with an excess amount of KC8. The radicals have been investigated by single-crystal X-ray crystallography, EPR and UV-Vis absorption spectroscopy, along with theoretical calculations...
January 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29348076/association-between-serum-arsenic-levels-and-gestational-diabetes-mellitus-a-population-based-birth-cohort-study
#4
Xun Xia, Chunmei Liang, Jie Sheng, Shuangqin Yan, Kun Huang, Zhijuan Li, Weijun Pan, Ruiwen Tao, Jiahu Hao, Beibei Zhu, Shilu Tong, Fangbiao Tao
Gestational diabetes mellitus (GDM) is a common obstetric complication with adverse effects on both mothers and their children. Previous studies revealed the link between Arsenic (As) exposure and incidence of diabetes mellitus (DM), but the data on the association between maternal As exposure and GDM is scarce. We examined this association among a population-based birth cohort. As concentrations were determined at multiple time points during pregnancy by ICP-MS. The association between As levels and GDM prevalence was examined using logistic regression model after adjustment for confounders...
January 15, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29346731/direct-polymerization-of-the-arsenic-drug-penao-to-obtain-nanoparticles-with-high-thiol-reactivity-and-anti-cancer-efficiency
#5
Janina-Miriam Noy, Hongxu Lu, Philip Hogg, Jia-Lin Yang, Martina H Stenzel
PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid), which is a mitochondria inhibitor that reacts with adenine nucleotide translocator (ANT), is currently being trialed in patients with solid tumors. To increase the stability of the drug, the formation of nanoparticles has been proposed. Herein, the direct synthesis of polymeric micelles based on the anti-cancer drug PENAO is presented. PENAO is readily available for amidation reaction to form PENAO MA (4-(N-(S-penicillaminylacetyl) amino) phenylarsonous acid methacrylamide) which undergoes RAFT (reversible addition fragmentation chin transfer) polymerization with poly(polyethylene glycol methyl ether methacrylate) (PEGMA) as comonomer and poly(methylmethacrylate) (pMMA) as chain transfer agent, resulting in p(MMA)-b-p(PEG-co-PENAO) block copolymers with 3-15 wt...
January 18, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29345188/arsenic-removal-from-alkaline-leaching-solution-using-fe-iii-precipitation
#6
Yongliang Wang, CuiCui Lv, Li Xiao, Guoyan Fu, Ya Liu, Shufeng Ye, Yunfa Chen
The alkaline leaching solution from arsenic-containing gold concentrate contains a large amount of arsenate ions, which should be removed due to its harm to the production and environmental protection. In this study, conventional Fe (III) precipitation was used to remove arsenic from leaching solution. The precipitation reaction was carried out at normal temperature, and the effects of pH value and Fe/As ratio on the arsenic removal were investigated. The results show that the removal rate of arsenic is distinctive at different pH values, and the effect is best within the pH range of 5...
January 18, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29341878/concentrations-of-arsenic-and-lead-in-rice-oryza-sativa-l-in-iran-a-systematic-review-and-carcinogenic-risk-assessment
#7
Yadolah Fakhri, Geir Bjørklund, Anoushiravan Mohseni Bandpei, Salvatore Chirumbolo, Hassan Keramati, Rokhsane Hosseini Pouya, Anvar Asadi, Nazak Amanidaz, Mansour Sarafraz, Amir Sheikhmohammadi, Zahra Baninameh, Seyed Mohsen Mohseni, Maryam Sarkhosh, Seyed Mehdi Ghasemi
Exposure to heavy metals such as arsenic (As), lead (Pb), and cadmium (Cd) in either the short or the long term can cause cancers in humans. Dietary intake and consumption of rice (Oryza sativa L.) is increasing in Iran, and several studies on the concentration of heavy metals in rice have been carried out in this country in recent years. In this perspective, the main objective of the present study was to investigate, even via a meta-analysis of the existing literature, the presence of As and Pb in rice from many geographical areas in Iran, as well as to estimate the carcinogenic risk of these heavy metals in rice consumers...
January 13, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29341365/how-and-why-helium-permeates-non-porous-arsenolite-under-high-pressure
#8
Piotr Aleksander Guńka, Michał Hapka, Michael Hanfland, Maciej Dranka, Grzegorz Chałasiński, Janusz Zachara
Investigations into the helium permeation of arsenolite, the cubic, molecular arsenic(III) oxide polymorph As₄O₆, were carried out in order to understand how and why arsenolite helium clathrate As₄O₆∙2He is formed. High-pressure synchrotron X-ray diffraction experiments on arsenolite single crystals revealed that the permeation of helium into non-porous arsenolite depends on the time during which the crystal is subjected to high pressure and on the crystal history. The single crystal was totally transformed into As₄O₆·2He within 45 h under 5 GPa...
January 17, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29339628/downregulation-of-long-non-coding-rna-kcnq1ot1-an-important-mechanism-of-arsenic-trioxide-induced-long-qt-syndrome
#9
Yanan Jiang, Weijie Du, Qun Chu, Ying Qin, Gulnara Tuguzbaeva, Hui Wang, Anqi Li, Guiyang Li, Yanyao Li, Lu Chai, Er Yue, Xi Sun, Zhiguo Wang, Valentin Pavlov, Baofeng Yang, Yunlong Bai
BACKGROUND/AIMS: Arsenic trioxide (ATO) is a known anti-acute promyelocytic leukemia (APL) reagent, whose clinical applications are limited by its serious cardiac toxicity and fatal adverse effects, such as sudden cardiac death resulting from long QT syndrome (LQTS). The mechanisms of cardiac arrhythmia due to ATO exposure still need to be elucidated. Long non-coding RNAs (lncRNAs) are emerging as major regulators of various pathophysiological processes. This study aimed to explore the involvement of lncRNAs in ATO-induced LQTS in vivo and in vitro...
January 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29336680/relating-soil-geochemical-properties-to-arsenic-bioaccessibility-through-hierarchical-modeling
#10
Clay M Nelson, Kevin Li, Daniel R Obenour, Jonathan Miller, John C Misenheimer, Kirk Scheckel, Aaron Betts, Albert Juhasz, David J Thomas, Karen D Bradham
Interest in improved understanding of relationships among soil properties and arsenic (As) bioaccessibility has motivated the use of regression models for As bioaccessibility prediction. However, limits in the numbers and types of soils included in previous studies restrict the usefulness of these models beyond the range of soil conditions evaluated, as evidenced by reduced predictive performance when applied to new data. In response, hierarchical models that consider variability in relationships among soil properties and As bioaccessibility across geographic locations and contaminant sources were developed to predict As bioaccessibility in 139 soils on both a mass fraction (mg/kg) and % basis...
January 16, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29336301/-acute-promyelocytic-leukaemia
#11
Michael Tøstesen, Lene S G Østergård, Eigil Kjeldsen, Jesper Stentoft, Jan M Nørgaard
Acute promyelocytic leukaemia has changed from being a highly fatal to a highly curable disease. Over time, key discoveries have identified the genetic and molecular abnormalities, which cause the disease. First choice of treatment has now changed from all-trans retinoic acid (ATRA) and chemotherapy to a chemo-free combination of arsenic trixoide and ATRA. This new regimen has shown equal responses and overall cure rates compared with the previous standard of care containing conventional chemotherapy, but with much lower toxicity...
January 15, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29336300/-successful-treatment-of-acute-promyelocytic-leukaemia-without-chemotherapy-and-blood-transfusion
#12
Michael Tøstesen, Lene S G Østgård, Eigil Kjeldsen, Jesper Stentoft, Jan M Nørgaard
Untreated acute promyelocytic leukaemia (APL) is a rapidly lethal blood cancer. Conventional treatment consists of all-trans retinoic acid and chemotherapy. Standard chemo-therapy-containing treatments necessitate the use of blood products. This is a case report of typical APL in a 32-year-old female patient, who due to religious conviction refused supportive therapy with blood products. A treatment regimen consisting of all-trans retinoic acid and arsenic trioxide was successful without the use of blood transfusions...
January 15, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29335874/mass-balance-of-arsenic-fluxes-in-rivers-impacted-by-gold-mining-activities-in-paracatu-minas-gerais-state-brazil
#13
Edison Bidone, Ricardo Cesar, Maria Carla Santos, Ricardo Sierpe, Emmanuel Vieira Silva-Filho, Vinicius Kutter, Lílian I Dias da Silva, Zuleica Castilhos
Arsenic (As) is a dangerous and carcinogenic element and drinking water is its main pathway of human exposure. Gold mines are widely recognized as important sources of As pollution. This work proposes the assessment of As distribution along watersheds surrounding "Morro do Ouro" gold mine (Paracatu, southeastern Brazil). A balance approach between filtered As fluxes (As < 0.45 μm) and suspended particulate material (AsSPM) in different river segments was applied. Ultrafiltration procedure was used to categorize As into the following classes: particulate > 0...
January 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29335219/thermal-removal-of-arsenic-from-copper-concentrates-three-dimensional-isothermal-predominance-diagrams-for-the-cu-as-s-o-system
#14
M Sadegh Safarzadeh, Stanley M Howard
The three-dimensional predominance volume diagrams (PVDs) for the system Cu-As-S-O were constructed at 900 K using [Formula: see text] as independent coordinates. The constant total pressure surface was used to identify the equilibrium phases that are stable at 0.25 atm total pressure. The isobaric surface superimposed on the predominance diagram provides useful insights into the roasting of complex copper sulfosalts such as enargite (Cu3AsS4) and tennantite (Cu12As4S13). There are nine interior invariant points each with four associated condensed phases at 900 K...
January 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29335176/arsenic-characteristics-in-the-terrestrial-environment-in-the-vicinity-of-the-shimen-realgar-mine-china
#15
Fen Yang, Shaowen Xie, Chaoyang Wei, Jinxin Liu, Hongzhi Zhang, Tao Chen, Jing Zhang
In this study, multiple types of samples, including soils, plants, litter and soil invertebrates, were collected from a former arsenic (As) mine in China. The total As concentrations in the soils, earthworms, litter and the aboveground portions of grass from the contaminated area followed the decreasing order of 83-2224 mg/kg, 31-430 mg/kg, 1-62 mg/kg and 2-23 mg/kg, respectively. X-ray absorption near-edge structure (XANES) analysis revealed that the predominant form of As in the soils was arsenate (As(V)), while no arsenite (As(III)) was detected...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29334960/arsenic-exposure-and-risk-of-nonalcoholic-fatty-liver-disease-nafld-among-u-s-adolescents-and-adults-an-association-modified-by-race-ethnicity-nhanes-2005-2014
#16
Jennifer K Frediani, Eric A Naioti, Miriam B Vos, Janet Figueroa, Carmen J Marsit, Jean A Welsh
BACKGROUND: While associated with obesity, the cause of the rapid rise in prevalence of nonalcoholic fatty liver disease (NAFLD) in children, which is highest among Hispanics, is not well understood. Animal experiments have demonstrated that arsenic exposure contributes to liver injury. Our objective was to examine the association between arsenic exposure and NAFLD in humans and to determine if race/ethnicity modifies the association. METHODS: Urinary inorganic arsenic concentrations among those ≥12 years in the National Health and Nutrition Examination Survey, 2005-2014 were used to assess the cross-sectional association with serum alanine aminotransferase (ALT) levels, a marker of liver dysfunction...
January 15, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29334871/biomonitoring-of-arsenic-in-woodworkers-exposed-to-cca-and-evaluation-of-other-non-occupational-sources-in-uruguay
#17
Valery Bühl, María Cristina Álvarez, María H Torre, Mariela Pistón, Nelly Mañay
In Uruguay wood-impregnation plants use chromated copper arsenate (CCA) as preservative applying good manufacture practices (GMP). This study aims a retrospective evaluation of toxicologically relevant species levels in CCA exposed woodworker's urine (As-U) and an assessment of the effects of work risk factors and non-occupational sources in As-U of workers from a selected plant. From 2014 to 2016, As-U in 212 urine samples (As-U) of 73 woodworkers from six CCA impregnation plants were determined. In one of these plants, 35 workers were interviewed to obtain individual data of work tasks, lifestyles, diet, habits, etc...
January 15, 2018: International Journal of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29331917/comparision-of-photocatalysis-and-photolysis-processes-for-arsenic-oxidation-in-water
#18
Klaiani B Fontana, Giane G Lenzi, Eriton C R Seára, Eduardo S Chaves
The oxidation of As(III) to As(V) in aqueous solution was evaluated using heterogeneous photocatalysis and photolysis. The influence of TiO2 as catalyst in different crystalline (rutile, anatase) and commercial forms was evaluated in a batch reactor and an insignificant difference was observed between them. The process by photocatalysis reached up to 97% As(III) oxidation and no significant difference was observed comparing to results obtained by photolysis. The photolysis experiments (UV radiation only), also carried out in a batch system, showed a high oxidation rate of As(III) (90% in 20min)...
January 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29331881/ameliorative-role-of-genistein-against-age-dependent-chronic-arsenic-toxicity-in-murine-brains-via-the-regulation-of-oxidative-stress-and-inflammatory-signaling-cascades
#19
Sukanya Saha, Pritam Sadhukhan, Sushweta Mahalanobish, Sayanta Dutta, Parames C Sil
Brain is highly prone to oxidative damage due to its huge lipid content and extensive energy requirements. Exogenous insult in brain via oxidative injury can lead to severe pathophysiological conditions. Age-dependent deterioration of normal brain functions is also noteworthy. Genistein, a polyphenolic isoflavonoid, obtained from the soy plant, is well known to protect against several diseased conditions. Here, in this study chronic brain toxicity model was developed using oral administration of arsenic for 90 days in adult and aged murines...
December 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331724/diminution-of-arsenic-accumulation-in-rice-seedlings-co-cultured-with-anabaena-sp-modulation-in-the-expression-of-lower-silicon-transporters-two-nitrogen-dependent-genes-and-lowering-of-antioxidants-activity
#20
Ruma Ranjan, Navin Kumar, Arvind Kumar Dubey, Ambedkar Gautam, Shyam Narain Pandey, Shekhar Mallick
The present study was intended to investigate the role of algae, Anabaena sp. in the amelioration of As toxicity, when co-cultured with rice seedlings. The reduction of growth in rice seedlings against As(III) and As(V) was recovered with Anabaena sp. The Anabaena sp. also reduced the accumulation of As, where it was more efficient against 60µM As(III) (49%) than As(V) (23%) in rice shoot. Similarly, with reduction of As accumulation, lower silicon transporters (Lsi-1 and Lsi-2) was found to be suppressed against As treatments...
January 10, 2018: Ecotoxicology and Environmental Safety
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