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https://www.readbyqxmd.com/read/28095176/a-flexible-workflow-for-automated-bioluminescent-kinase-selectivity-profiling
#1
Tracy Worzella, Matt Butzler, Jacquelyn Hennek, Seth Hanson, Laura Simdon, Said Goueli, Cris Cowan, Hicham Zegzouti
Kinase profiling during drug discovery is a necessary process to confirm inhibitor selectivity and assess off-target activities. However, cost and logistical limitations prevent profiling activities from being performed in-house. We describe the development of an automated and flexible kinase profiling workflow that combines ready-to-use kinase enzymes and substrates in convenient eight-tube strips, a bench-top liquid handling device, ADP-Glo Kinase Assay (Promega, Madison, WI) technology to quantify enzyme activity, and a multimode detection instrument...
November 1, 2016: Journal of Laboratory Automation
https://www.readbyqxmd.com/read/28093122/sequential-enzymatic-derivatization-coupled-with-online-microdialysis-sampling-for-simultaneous-profiling-of-mouse-tumor-extracellular-hydrogen-peroxide-lactate-and-glucose
#2
Cheng-Kuan Su, Po-Jen Tseng, Hsien-Ting Chiu, Andrea Del Vall, Yu-Fen Huang, Yuh-Chang Sun
Probing tumor extracellular metabolites is a vitally important issue in current cancer biology. In this study an analytical system was constructed for the in vivo monitoring of mouse tumor extracellular hydrogen peroxide (H2O2), lactate, and glucose by means of microdialysis (MD) sampling and fluorescence determination in conjunction with a smart sequential enzymatic derivatization scheme-involving a loading sequence of fluorogenic reagent/horseradish peroxidase, microdialysate, lactate oxidase, pyruvate, and glucose oxidase-for step-by-step determination of sampled H2O2, lactate, and glucose in mouse tumor microdialysate...
March 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28089562/sequential-multiple-assignment-randomized-trials-an-opportunity-for-improved-design-of-stroke-reperfusion-trials
#3
William J Meurer, Nicholas J Seewald, Kelley Kidwell
BACKGROUND: Modern clinical trials in stroke reperfusion fall into 2 categories: alternative systemic pharmacological regimens to alteplase and "rescue" endovascular approaches using targeted thrombectomy devices and/or medications delivered directly for persistently occluded vessels. Clinical trials in stroke have not evaluated how initial pharmacological thrombolytic management might influence subsequent rescue strategy. A sequential multiple assignment randomized trial (SMART) is a novel trial design that can test these dynamic treatment regimens and lead to treatment guidelines that more closely mimic practice...
January 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28079384/hypoxia-and-h2o2-dual-sensitive-vesicles-for-enhanced-glucose-responsive-insulin-delivery
#4
Jicheng Yu, Chenggen Qian, Yuqi Zhang, Zheng Cui, Yong Zhu, Qundong Shen, Frances S Ligler, John B Buse, Zhen Gu
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive insulin delivery device using a painless microneedle-array patch containing insulin-loaded vesicles. Formed by self-assembly of hypoxia and H2O2 dual-sensitive diblock copolymer, the glucose-responsive polymersome-based vesicles (d-GRPs) can disassociate and subsequently release insulin triggered by H2O2 and hypoxia generated during glucose oxidation catalyzed by glucose specific enzyme...
January 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28076861/potential-applications-of-smart-multifunctional-wearable-materials-to-gerontology
#5
David G Armstrong, Bijan Najafi, Mohsen Shahinpoor
Smart multifunctional materials can play a constructive role in addressing some very important aging-related issues. Aging affects the ability of older adults to continue to live safely and economically in their own residences for as long as possible. Thus, there will be a greater need for preventive, acute, rehabilitative, and long-term health care services for older adults as well as a need for tools to enable them to function independently during daily activities. The objective of this paper is, thus, to present a comprehensive review of some potential smart materials and their areas of applications to gerontology...
January 12, 2017: Gerontology
https://www.readbyqxmd.com/read/28071895/flexible-cuttable-and-self-waterproof-bending-strain-sensors-using-microcracked-gold-nanofilms-paper-substrate
#6
Xinqin Liao, Zheng Zhang, Qijie Liang, Qingliang Liao, Yue Zhang
Rapid advances in functional sensing electronics place tremendous demands on innovation towards creative uses of versatile advanced materials and effective designs of device structures. Here, we first report a feasible and effective fabrication strategy to integrate commercial abrasive papers with microcracked gold (Au) nanofilms to construct cuttable and self-waterproof crack-based resistive bending strain sensors. Via introducing surface microstructures, the sensitivities of the bending strain sensors are greatly enhanced by 27 times than that of the sensors without surface microstructures, putting forward an alternative suggestion for other flexible electronics to improve their performances...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28058697/macro-scale-model-study-of-a-tunable-drug-dispensation-mechanism-for-controlled-drug-delivery-in-potential-wound-healing-applications
#7
Mariam Mir, Umar Ansari, Murtaza Najabat Ali
BACKGROUND: Auxetic materials tend to exhibit stretching in the direction of the applied load as well as in the perpendicular direction. This may be an inherent property of the material, or it might be a particular structural characteristic that confers it with auxetic properties. In this study, the auxetic properties of a rotating squares auxetic design were utilized in tandem with a stretching mechanism to manufacture a device that offers the advantages of adjustable pore size and hence tunable drug delivery characteristics...
October 10, 2016: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28056170/self-sterilized-flexible-single-electrode-triboelectric-nanogenerator-for-energy-harvesting-and-dynamic-force-sensing
#8
Huijuan Guo, Tao Li, Xiaotao Cao, Jin Xiong, Yang Jie, Magnus Willander, Xia Cao, Ning Wang, Zhong Lin Wang
Triboelectric nanogenerators (TENGs) offer great opportunities to deploy advanced wearable electronics that integrate a power generator and smart sensor, which eliminates the associated cost and sustainability concerns. Here, an embodiment of such integrated platforms has been presented in a graphene oxide (GO) based single-electrode TENG (S-TENG). The as-designed multifunctional device could not only harvest tiny bits of mechanical energy from ambient movements with a high power density of 3.13 W·m(-2) but also enable detecting dynamic force with an excellent sensitivity of about 388 μA·MPa(-1)...
January 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28054382/bioinspired-coupling-of-inorganic-layered-nanomaterials-with-marine-polysaccharides-for-efficient-aqueous-exfoliation-and-smart-actuating-hybrids
#9
Lu Zong, Mingjie Li, Chaoxu Li
WS2 and marine alginate are perfectly coupled to ensure scalable production of exfoliated WS2 with unprecedented efficiency, further providing super mechanical properties and the photothermal effect to their composites. Combined with the water-intake and cation-binding capabilities of alginate, biomimetic soft devices are designed with stimuli-responsiveness and actuating properties, capable of serving as a photo-driven motor, walking robot and gripper.
January 5, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28051306/h2o2-responsive-vesicles-integrated-with-transcutaneous-patches-for-glucose-mediated-insulin-delivery
#10
Xiuli Hu, Jicheng Yu, Chenggen Qian, Yue Lu, Anna R Kahkoska, Zhigang Xie, Xiabin Jing, John B Buse, Zhen Gu
A self-regulated "smart" insulin administration system would be highly desirable for diabetes management. Here, a glucose-responsive insulin delivery device, which integrates H2O2-responsive polymeric vesicles (PVs) with a transcutaneous microneedle-array patch was prepared to achieve a fast response, excellent biocompatibility, and painless administration. The PVs are self-assembled from block copolymer incorporated with polyethylene glycol (PEG) and phenylboronic ester (PBE)-conjugated polyserine (designated mPEG-b-P(Ser-PBE)) and loaded with glucose oxidase (GOx) and insulin...
January 4, 2017: ACS Nano
https://www.readbyqxmd.com/read/28042863/evaluating-the-more-suitable-ism-frequency-band-for-iot-based-smart-grids-a-quantitative-study-of-915-mhz-vs-2400-mhz
#11
Ruben M Sandoval, Antonio-Javier Garcia-Sanchez, Felipe Garcia-Sanchez, Joan Garcia-Haro
IoT has begun to be employed pervasively in industrial environments and critical infrastructures thanks to its positive impact on performance and efficiency. Among these environments, the Smart Grid (SG) excels as the perfect host for this technology, mainly due to its potential to become the motor of the rest of electrically-dependent infrastructures. To make this SG-oriented IoT cost-effective, most deployments employ unlicensed ISM bands, specifically the 2400 MHz one, due to its extended communication bandwidth in comparison with lower bands...
December 31, 2016: Sensors
https://www.readbyqxmd.com/read/28036081/odor-sensing-system-to-support-social-participation-of-people-suffering-from-incontinence
#12
Alvaro Ortiz Pérez, Vera Kallfaß-de Frenes, Alexander Filbert, Janosch Kneer, Benedikt Bierer, Pirmin Held, Philipp Klein, Jürgen Wöllenstein, Dirk Benyoucef, Sigrid Kallfaß, Ulrich Mescheder, Stefan Palzer
This manuscript describes the design considerations, implementation, and laboratory validation of an odor sensing module whose purpose is to support people that suffer from incontinence. Because of the requirements expressed by the affected end-users the odor sensing unit is realized as a portable accessory that may be connected to any pre-existing smart device. We have opted for a low-cost, low-power consuming metal oxide based gas detection approach to highlight the viability of developing an inexpensive yet helpful odor recognition technology...
December 29, 2016: Sensors
https://www.readbyqxmd.com/read/28029761/switchable-photonic-crystals-using-one-dimensional-confined-liquid-crystals-for-photonic-device-application
#13
Seong Ho Ryu, Min-Jun Gim, Wonsuk Lee, Suk-Won Choi, Dong Ki Yoon
Photonic crystals (PCs) have recently attracted considerable attention, with much effort devoted to photonic bandgap (PBG) control for varying the reflected color. Here, fabrication of a modulated one-dimensional (1D) anodic aluminum oxide (AAO) PC with a periodic porous structure is reported. The PBG of the fabricated PC can be reversibly changed by switching the ultraviolet (UV) light on/off. The AAO nanopores contain a mixture of photoresponsive liquid crystals (LCs) with irradiation-activated cis/trans photoisomerizable azobenzene...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28029142/an-indoor-positioning-system-based-on-wearables-for-ambient-assisted-living
#14
Óscar Belmonte-Fernández, Adrian Puertas-Cabedo, Joaquín Torres-Sospedra, Raúl Montoliu-Colás, Sergi Trilles-Oliver
The urban population is growing at such a rate that by 2050 it is estimated that 84% of the world's population will live in cities, with flats being the most common living place. Moreover, WiFi technology is present in most developed country urban areas, with a quick growth in developing countries. New Ambient-Assisted Living applications will be developed in the near future having user positioning as ground technology: elderly tele-care, energy consumption, security and the like are strongly based on indoor positioning information...
December 25, 2016: Sensors
https://www.readbyqxmd.com/read/28026935/thermoresponsive-semi-ipn-hydrogel-microfibers-from-continuous-fluidic-processing-with-high-elasticity-and-fast-actuation
#15
Yan Liu, Kaihuan Zhang, Jinghong Ma, G Julius Vancso
Hydrogels with rapid and strong response to external stimuli and possessing high elasticity and strength have been considered as platform materials for numerous applications, e.g., in biomaterials engineering. Thermoresponsive hydrogels based on semi-interpenetrating polymer networks (semi-IPN) featuring N-isopropylacrylamide with copolymers of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) p(NIPAM-HEMA) chains are prepared and described. The copolymer was characterized by FTIR, NMR, and GPC. The semi-IPN structured hydrogel and its responsive properties were evaluated by dynamic mechanical measurements, SEM, DSC, equilibrium swelling ratio, and dynamic deswelling tests...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28024385/controlling-stiction-in-nano-electro-mechanical-systems-using-liquid-crystals
#16
Oleksandr Buchnev, Nina Podoliak, Thomas Frank, Malgosia Kaczmarek, Liudi Jiang, Vassili A Fedotov
Stiction is one of the major reliability issues limiting practical application of nano-electro-mechanical systems (NEMS), an emerging device technology that exploits mechanical movements on the scale of an integrated electronic circuit. We report on a discovery that stiction can be eliminated by infiltrating NEMS with nematic liquid crystals. We demonstrate this experimentally using a NEMS-based tunable photonic metamaterial, where reliable switching of optical response was achieved for the entire range of nanoscopic structural displacements admitted by the metamaterial design...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28024371/high-performance-flexible-thermoelectric-power-generator-using-laser-multiscanning-lift-off-process
#17
Sun Jin Kim, Han Eol Lee, Hyeongdo Choi, Yongjun Kim, Ju Hyung We, Ji Seon Shin, Keon Jae Lee, Byung Jin Cho
Flexible thermoelectric generators (f-TEGs) are emerging as a semipermanent power source for self-powered sensors, which is an important area of research for next-generation smart network monitoring systems in the Internet-of-things era. We report in this paper a f-TEG produced by a screen-printing technique (SPT) and a laser multiscanning (LMS) lift-off process. A screen-printed TEG was fabricated on a SiO2/a-Si/quartz substrate via the SPT process, and the LMS process completely separated the rigid quartz substrate from the original TEG by selective reaction of the XeCl excimer laser with the exfoliation layer (a-Si)...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28018210/measuring-the-moment-to-moment-variability-of-tinnitus-the-trackyourtinnitus-smart-phone-app
#18
Winfried Schlee, Rüdiger C Pryss, Thomas Probst, Johannes Schobel, Alexander Bachmeier, Manfred Reichert, Berthold Langguth
Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnitus perception fluctuates over time. It is therefore necessary to develop tools for measuring fluctuations of tinnitus perception over time and for analyzing data on single subject basis. However, this type of longitudinal measurement is difficult to perform using the traditional research methods such as paper-and-pencil questionnaires or clinical interviews...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28012843/validation-of-a-novel-cognitive-simulator-for-orbital-floor-reconstruction
#19
Renata Khelemsky, Brianna Hill, Daniel Buchbinder
PURPOSE: The increasing focus on patient safety in current medical practice has promoted the development of surgical simulation technology in the form of virtual reality (VR) training designed largely to improve technical skills and less so for nontechnical aspects of surgery such as decision making and material knowledge. The present study investigated the validity of a novel cognitive VR simulator called Touch Surgery for a core maxillofacial surgical procedure: orbital floor reconstruction (OFR)...
December 11, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28009835/smart-device-supported-bds-gnss-real-time-kinematic-positioning-for-sub-meter-level-accuracy-in-urban-location-based-services
#20
Liang Wang, Zishen Li, Jiaojiao Zhao, Kai Zhou, Zhiyu Wang, Hong Yuan
Using mobile smart devices to provide urban location-based services (LBS) with sub-meter-level accuracy (around 0.5 m) is a major application field for future global navigation satellite system (GNSS) development. Real-time kinematic (RTK) positioning, which is a widely used GNSS-based positioning approach, can improve the accuracy from about 10-20 m (achieved by the standard positioning services) to about 3-5 cm based on the geodetic receivers. In using the smart devices to achieve positioning with sub-meter-level accuracy, a feasible solution of combining the low-cost GNSS module and the smart device is proposed in this work and a user-side GNSS RTK positioning software was developed from scratch based on the Android platform...
December 21, 2016: Sensors
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