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https://www.readbyqxmd.com/read/28239840/melasma-systematic-review-of-the-systemic-treatments
#1
REVIEW
Linghong Linda Zhou, Akerke Baibergenova
Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. We sought to evaluate the efficacy and safety/tolerability of oral medications and dietary supplements for the treatment of melasma...
February 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28238351/antenatal-weight-management-diet-physical-activity-and-gestational-weight-gain-in-early-pregnancy
#2
Judy A Swift, Kirsty J Elliott-Sale, Jo Pearce, Preeti H Jethwa, Moira A Taylor, Amanda Avery, Sarah Ellis, Simon C Langley-Evans, Sarah McMullen
OBJECTIVE: to investigate women's physical activity levels, diet and gestational weight gain, and their experiences and motivations of behavior change. DESIGN: analysis of cross-sectional data collected during a longitudinal, cohort study examining physiological, psychological, sociodemographic, and self-reported behavioural measures relating to bodyweight. SETTING: women recruited from routine antenatal clinics at the Nottingham University Hospitals NHS Trust...
January 31, 2017: Midwifery
https://www.readbyqxmd.com/read/28229388/effects-of-boron-supplementation-on-peripartum-dairy-cows-health
#3
Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Alessia Vignoli, Erdem Gulersoy
Although many different dietary studies on the prevention of negative energy balance related diseases are often encountered, this is the first study investigating the effects of boron supplementation on peripartum dairy cows' health in the light of an omics approach. Twenty-eight healthy cows (1 control and 3 experimental groups) were enrolled from 2 months before predicted calving until 2 months after calving. Experimental groups were assigned to receive boron at increasing doses as an oral bolus. Production parameters, biochemical profile, Nuclear Magnetic Resonance based metabolomics profile, and mRNA abundance of gluconeogenic enzymes and lipid oxidation genes were determined...
February 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28228421/randomized-clinical-trial-in-vitamin-d-deficient-adults-comparing-replenishment-with-oral-vitamin-d3-with-narrow-band-uv-type-b-light-effects-on-cholesterol-and-the-transcriptional-profiles-of-skin-and-blood
#4
Manish P Ponda, Yupu Liang, Jaehwan Kim, Richard Hutt, Kathleen Dowd, Patricia Gilleaudeau, Mary M Sullivan-Whalen, Tori Rodrick, Dong Joo Kim, Irina Barash, Michelle A Lowes, Jan L Breslow
Background: Vitamin D deficiency, defined as a serum 25-hydroxyvitamin D [25(OH)D] concentration <20 ng/mL, is correlated with a more atherogenic lipid profile. However, oral vitamin D supplementation does not lower LDL-cholesterol concentrations or raise HDL-cholesterol concentrations. This uncoupling between association and causation may result from a failure of oral vitamin D to mimic the effect of dermally synthesized vitamin D in response to ultraviolet type B (UVB) light.Objective: We tested the hypothesis that, in vitamin D-deficient adults, the replenishment of vitamin D with UVB exposure would lower LDL-cholesterol concentrations compared with the effect of oral vitamin D3 supplementation...
February 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28220480/quality-and-stability-of-extemporaneous-pyridoxal-phosphate-preparations-used-in-the-treatment-of-paediatric-epilepsy
#5
Abeer H A Mohamed-Ahmed, Matthew P Wilson, Maedelyn Albuera, Ting Chen, Philippa B Mills, Emma J Footitt, Peter T Clayton, Catherine Tuleu
OBJECTIVES: To assess the pyridoxal 5'-phosphate (PLP) content and stability of extemporaneous PLP liquids prepared from dietary supplements used for the treatment of vitamin B6 -dependent epilepsy. METHODS: Pyridoxal 5'-phosphate liquids were prepared in accordance with the guidelines given to patients from marketed 50 mg PLP dietary capsules and tablets. The PLP content and its stability were evaluated under conditions resembling the clinical setting using reverse phase HPLC and mass spectrometry...
February 21, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28219840/effect-of-surface-functionalisation-on-the-interaction-of-iron-oxide-nanoparticles-with-polymerase-chain-reaction
#6
Ayse Beyza Aysan, Zdeněk Knejzlík, Pavel Ulbrich, Marek Šoltys, Aleš Zadražil, František Štěpánek
The combination of nanoparticles with the polymerase chain reaction (PCR) can have benefits such as easier sample handling or higher sensitivity, but also drawbacks such as loss of colloidal stability or inhibition of the PCR. The present work systematically investigates the interaction of magnetic iron oxide nanoparticles (MIONs) with the PCR in terms of colloidal stability and potential PCR inhibition due to interaction between the PCR components and the nanoparticle surface. Several types of MIONs with and without surface functionalisation by sodium citrate, dextran and 3-aminopropyl-triethoxysilane (APTES) were prepared and characterised by Transmission Electron Microscopy (TEM), dynamic light scattering (DLS) and Fourier Transform Infrared (FT-IR) spectroscopy...
February 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28216339/the-effect-of-tribulus-terrestris-extract-on-motility-and-viability-of-human-sperms-after-cryopreservation
#7
Atefeh Asadmobini, Mitra Bakhtiari, Sara Khaleghi, Farzaneh Esmaeili, Ali Mostafaei
BACKGROUND: Semen cryopreservation produces significant amounts of reactive oxygen species (ROS), which may lead to impairment of sperm morphology, function, and ultimately, male fertility. Since Tribulus terrestris has antioxidant and free-radical-scavenging properties, this study aims to reveal the effect of the Tribulus terrestris extract on motility and vitality of human sperms after cryopreservation. MATERIALS AND METHODS: Semen specimens from 80 healthy volunteers were divided into eight groups: fresh control (group I), freeze control (group II), groups III, IV, and V, which had 20, 40, and 50 μg/mL doses of Tribulus terrestris extract added before cryopreservation, and groups VI, VII, and VIII, which were supplemented by these extract doses after the freeze-thaw process...
February 17, 2017: Cryobiology
https://www.readbyqxmd.com/read/28215310/review-of-the-mechanisms-of-probiotic-actions-in-the-prevention-of-colorectal-cancer
#8
REVIEW
Sandra A Dos Reis, Lisiane L da Conceição, Nathane P Siqueira, Damiana D Rosa, Letícia L da Silva, Maria do Carmo G Peluzio
The purpose of this review is to discuss the potential mechanisms of probiotics action in colorectal cancer prevention. In this regard, the composition of the intestinal microbiota is considered as an important risk factor in the development of colorectal cancer, and probiotics are able to positively modulate the composition of this microbiota. Studies have shown that the regular consumption of probiotics could prevent the development of colorectal cancer. In this respect, in vitro and experimental studies suggest some potential mechanisms responsible for this anticarcinogenic action...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28212511/arsenic-hyperaccumulator-pteris-vittata-efficiently-solubilized-phosphate-rock-to-sustain-plant-growth-and-as-uptake
#9
Jing-Wei Fu, Xue Liu, Yong-He Han, Hanyi Mei, Yue Cao, Letuzia M de Oliveira, Yungen Liu, Bala Rathinasabapathi, Yanshan Chen, Lena Q Ma
Phosphorus (P) is one of the most important nutrients for phytoremediation of arsenic (As)-contaminated soils. In this study, we demonstrated that As-hyperaccumulator Pteris vittata was efficient in acquiring P from insoluble phosphate rock (PR). When supplemented with PR as the sole P source in hydroponic systems, P. vittata accumulated 49% and 28% higher P in the roots and fronds than the -P treatment. In contrast, non-hyperaccumulator Pteris ensiformis was unable to solubilize P from PR. To gain insights into PR solubilization by plants, organic acids in plant root exudates were analyzed by HPLC...
January 31, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28212404/the-pineal-gland-a-model-for-adrenergic-modulation-of-ubiquitin-ligases
#10
Jerry Vriend, Wenjun Liu, Russel J Reiter
INTRODUCTION: A recent study of the pineal gland of the rat found that the expression of more than 3000 genes showed significant day/night variations (The Hartley dataset). The investigators of this report made available a supplemental table in which they tabulated the expression of many genes that they did not discuss, including those coding for components of the ubiquitin proteasome system. Herein we identify the genes of the ubiquitin proteasome system whose expression were significantly influenced by environmental lighting in the Hartley dataset, those that were stimulated by DBcAMP in pineal glands in culture, and those that were stimulated by norepinephrine...
2017: PloS One
https://www.readbyqxmd.com/read/28206978/pathogenic-roles-of-alterations-in-vitamin-d-and-vitamin-d-receptor-in-gastric-tumorigenesis
#11
REVIEW
Chao Du, Shiming Yang, Xiaoyan Zhao, Hui Dong
Gastric cancer is currently the second leading cause of cancer-related death worldwide, especially in Japan, Korea and China, and the 5-year survival rate of gastric cancer is less than 30%. Thus, it is important to shed more lights on novel agents to prevent gastric cancer or to improve survival rate of the patients. Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Although epidemiological results are not consistent, accumulating evidence from gastric cancer cells, animal models, and clinical trials suggest that vitamin D deficiency may increase the risk and mortality of gastric cancer, but vitamin D supplement might be a safe and economical way to prevent or treat gastric cancer...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28197342/the-function-of-fgfr1-signalling-in-the-spinal-cord-therapeutic-approaches-using-fgfr1-ligands-after-spinal-cord-injury
#12
REVIEW
Barbara Haenzi, Lawrence D F Moon
Extensive research is ongoing that concentrates on finding therapies to enhance CNS regeneration after spinal cord injury (SCI) and to cure paralysis. This review sheds light on the role of the FGFR pathway in the injured spinal cord and discusses various therapies that use FGFR activating ligands to promote regeneration after SCI. We discuss studies that use peripheral nerve grafts or Schwann cell grafts in combination with FGF1 or FGF2 supplementation. Most of these studies show evidence that these therapies successfully enhance axon regeneration into the graft...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28196087/the-potential-of-indigenous-paenibacillus-ehimensis-bs1-for-recovering-heavy-crude-oil-by-biotransformation-to-light-fractions
#13
Biji Shibulal, Saif N Al-Bahry, Yahya M Al-Wahaibi, Abdulkadir E Elshafie, Ali S Al-Bemani, Sanket J Joshi
Microbial Enhanced Oil Recovery (MEOR) is a potential technology for residual heavy oil recovery. Many heavy oil fields in Oman and elsewhere have difficulty in crude oil recovery because it is expensive due to its high viscosity. Indigenous microbes are capable of improving the fluidity of heavy oil, by changing its high viscosity and producing lighter oil fractions. Many spore-forming bacteria were isolated from soil samples collected from oil fields in Oman. Among the isolates, an autochthonous spore-forming bacterium was found to enhance heavy oil recovery, which was identified by 16S rDNA sequencing as Paenibacillus ehimensis BS1...
2017: PloS One
https://www.readbyqxmd.com/read/28188256/mgdg-pg-and-sqdg-regulate-the-activity-of-light-dependent-protochlorophyllide-oxidoreductase
#14
Michal Gabruk, Beata Myśliwa-Kurdziel, Jerzy Kruk
Light-dependent protochlorophyllide oxidoreductase (POR) is a plant enzyme involved in the chlorophyll biosynthesis pathway. POR reduces one of the double bonds of the protochlorophyllide (Pchlide) using NADPH and light. In the present paper, we found out that PG and SQDG are allosteric regulators of the nucleotide binding, which increase the affinity towards NADPH a hundred fold. Moreover, we showed for the first time that NADH can, like NADPH, form active complexes with Pchlide and POR, however at much higher concentrations...
February 10, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28187454/grape-seed-extracts-modify-the-outcome-of-oxaliplatin-in-colon-cancer-cells-by-interfering-with-cellular-mechanisms-of-drug-cytotoxicity
#15
Letizia Porcelli, Rosa Maria Iacobazzi, Anna Elisa Quatrale, Carlo Bergamini, Nunzio Denora, Pasquale Crupi, Donato Antonacci, Anita Mangia, Giovanni Simone, Nicola Silvestris, Amalia Azzariti
Grape seed extracts are commonly utilized as dietary supplements for their antioxidant properties, even from cancer patients. However, whether these natural extracts interfere with chemotherapeutics utilized in colon cancer treatment is still poorly investigated. The cytotoxicity of extracts from Italia and Palieri cultivars either alone or in combination with oxaliplatin was evaluated in colon cancer cells. Grape seed extracts displayed anti-proliferative activity depending on the concentration utilized through apoptosis induction...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177391/effect-of-oral-supplementation-with-different-energy-boosters-in-newborn-piglets-on-pre-weaning-mortality-growth-and-serological-levels-of-igf-i-and-igg
#16
R Muns, M Nuntapaitoon, P Tummaruk
Oral supplements are commonly used in commercial herds to improve energy status and passive immune acquisition of newborn piglets. However, there is little scientific evidence on the efficacy of oral supplements for piglets. The objective of this experiment was to study the effects of 2 oral supplementation products on piglet pre-weaning mortality and growth. A total of 62 litters (749 piglets) were distributed according to the sow's parity among 3 treatments: 1) CONTROL group, no oral supplementation to piglets; 2) EN group, light piglets (LP: birth BW ≤ 1...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28177351/effects-of-increasing-inclusion-of-sodium-hydroxide-treatment-on-growth-performance-carcass-characteristics-and-feeding-behavior-of-steers-fed-50-ddgs
#17
T B Freitas, A E Relling, M S Pedreira, W J B Rocha, A R Schroeder, T L Felix
Objectives were to determine the dietary inclusion level of NaOH in a dried distillers grains with solubles (DDGS)-based diet needed to improve growth performance and carcass characteristics of feedlot steers, and to determine the effects of NaOH treatment of DDGS on pattern of feed intake. Based on previous research regarding the acidity of DDGS, we hypothesized that using NaOH in cattle fed 50% DDGS-based diets to neutralize the acidity inherent in DDGS would improve growth performance of cattle but shift intake patterns...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28174780/shedding-light-on-the-biological-and-chemical-fingerprints-of-three-achillea-species-a-biebersteinii-a-millefolium-and-a-teretifolia
#18
Gokhan Zengin, Abdurrahman Aktumsek, Ramazan Ceylan, Sengul Uysal, Andrei Mocan, Gokalp Ozmen Guler, M Fawzi Mahomoodally, Jasmina Glamočlija, Ana Ćirić, Marina Soković
Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). The antioxidant (free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum), enzyme inhibitory (anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase) and antimicrobial (antibacterial and antifungal) effects were assessed to investigate their biological profiles...
February 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28173617/specificity-of-root-microbiomes-in-native-grown-nicotiana-attenuata-and-plant-responses-to-uvb-increase-deinococcus-colonization
#19
Rakesh Santhanam, Youngjoo Oh, Ramesh Kumar, Arne Weinhold, Van Thi Luu, Karin Groten, Ian T Baldwin
Plants recruit microbial communities from the soil in which they germinate. Our understanding of the recruitment process and the factors affecting it is still limited for most microbial taxa. We analyzed several factors potentially affecting root microbiome structure - the importance of geographic location of natural populations, the microbiome of native seeds as putative source of colonization and the effect of a plant's response to UVB-exposure on root colonization of highly abundant species. The microbiome of Nicotiana attenuata seeds was determined by a culture-dependent and independent approach, and the root microbiome of natural N...
February 7, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28167940/narrowband-uvb-phototherapy-for-clinically-isolated-syndrome-a-trial-to-deliver-the-benefits-of-vitamin-d-and-other-uvb-induced-molecules
#20
Prue H Hart, Robyn M Lucas, David R Booth, William M Carroll, David Nolan, Judith M Cole, Anderson P Jones, Allan G Kermode
Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for MS development of higher 25(OH)D comes from observational studies, but this study design cannot separate out whether 25(OH)D is acting as a marker of vitamin D status, sun exposure, or both. In light of a lack of definitive outcomes in MS patients after trials of vitamin D supplementation and the ability of narrowband UVB to induce vitamin D, as well as other immune-regulatory molecules in skin, the Phototherapy for Clinically Isolated Syndrome (PhoCIS) trial was established to investigate the benefits of narrowband UVB, in addition to supplemented vitamin D, on MS development in individuals with Clinically Isolated Syndrome...
2017: Frontiers in Immunology
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