Ruying Tang, Linyuan Wang, Jianjun Zhang, Wenting Fei, Rui Zhang, Jinlian Liu, Meiyu Lv, Mengyao Wang, Ruilin Lv, Haipeng Nan, Ran Tao, Yawen Chen, Yan Chen, Yanxin Jiang, Hui Zhang
INTRODUCTION: In light of the public health burden of the COVID-19 pandemic, boosting the safety and immunogenicity of COVID-19 vaccines is of great concern. Numerous Traditional Chinese medicine (TCM) preparations have shown to beneficially modulate immunity. Based on pilot experiments in mice that showed that supplementation with Huoxiang Suling Shuanghua Decoction (HSSD) significantly enhances serum anti-RBD IgG titers after inoculation with recombinant SARS-CoV-2 S-RBD protein, we conducted this randomized, double-blind, placebo-controlled clinical trial aimed to evaluate the potential immunogenicity boosting effect of oral HSSD after a third homologous immunization with Sinovac's CoronaVac SARS-CoV-2 (CVS) inactivated vaccine...
2024: Frontiers in Immunology