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https://www.readbyqxmd.com/read/29454888/bioequivalence-decision-for-nanoparticular-iron-complex-drugs-for-parenteral-administration-based-on-their-disposition
#1
Julia Schnorr, Sören Fütterer, Karsten Spicher, Maria Catarinolo, Christoph Schlösser, Harald Enzmann, Peter Langguth
Although parenteral iron products have been established to medicinal use decades before, their structure and pharmacokinetic properties are not fully characterized yet. With its' second reflection paper on intravenous iron-based nano-colloidal products (EMA/CHMP/SWP/620008/2012) the European Medicine Agency provided an extensive catalogue of methods for quality, non-clinical and pharmacokinetic studies for the comparison of nano-sized iron products to an originator (EMA, 2015). For iron distribution studies, the reflection paper assumed the use of rodents...
February 15, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29452128/are-sleep-disturbances-causally-linked-to-the-presence-and-severity-of-psychotic-like-dissociative-and-hypomanic-experiences-in-non-clinical-populations-a-systematic-review
#2
REVIEW
Jack Barton, Simon D Kyle, Filippo Varese, Steven H Jones, Gillian Haddock
The present review aimed to 1) identify what sleep disturbances co-occur alongside psychotic-like, dissociative and hypomanic experiences; 2) assess the strength of potential associations between the severity of sleep disturbances and of the experiences studied; and 3) appraise evidence for a causal link. MedLine and PsycInfo were searched and 44 studies were deemed eligible. Results showed that insomnia was associated with all individual psychotic-like, dissociative and hypomanic experiences reviewed (effect size range: small-to-large)...
February 13, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29451590/by-the-book-adhd-prevalence-in-medical-students-varies-with-analogous-methods-of-addressing-dsm-items
#3
Paulo Mattos, Bruno P Nazar, Rosemary Tannock
OBJECTIVE: The marked increase in the prevalence of attention-deficit/hyperactivity disorder (ADHD) among university students gives rise to questions about how best to diagnose in this setting. The aim of the present study was to calculate ADHD prevalence in a large non-clinical sample of medical students using a stepwise design and to determine whether ADHD diagnosis varies if interviewees use additional probing procedures to obtain examples of positive DSM items. METHODS: A total of 726 students were screened with the Adult Self-Report Scale (ASRS) and invited for an interview with the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) adapted for adults...
February 15, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29449779/-saccharomyces-boulardii-cncm-i-745-improves-intestinal-enzyme-function-a-trophic-effects-review
#4
REVIEW
Margret I Moré, Yvan Vandenplas
Several properties of the probiotic medicinal yeast Saccharomyces boulardii CNCM I-745 contribute to its efficacy to prevent or treat diarrhoea. Besides immunologic effects, pathogen-binding and anti-toxin effects, as well as positive effects on the microbiota, S boulardii CNCM I-745 also has pronounced effects on digestive enzymes of the brush border membrane, known as trophic effects. The latter are the focus of this review. Literature has been reviewed after searching Medline and PMC databases. All relevant non-clinical and clinical studies are summarized...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29447619/autism-spectrum-disorder-traits-in-typically-developing-emerging-adults-and-associated-parenting-a-person-centered-approach
#5
Cliff McKinney, Daniel L Gadke, Mallory L Malkin
Research on parenting children with autism spectrum disorder (ASD) indicates these children receive parenting tailored to their condition. However, little is known about ASD in adulthood, especially in emerging adults at college, and how they are parented. The current study examined how emerging adults in a non-clinical typically-developing sample differed in their current perceptions of parenting as a function of ASD traits. Participants completed questionnaires about their current perceptions of parenting and self-reported ASD traits...
February 15, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29447056/investigating-the-psychometric-properties-of-the-revised-child-anxiety-and-depression-scale-rcads-in-a-non-clinical-sample-of-irish-adolescents
#6
Alanna Donnelly, Amanda Fitzgerald, Mark Shevlin, Barbara Dooley
BACKGROUND: The psychometric properties of the Revised Child Anxiety and Depression Scale (RCADS) have been established cross-culturally, yet psychometric evidence is lacking for an English-speaking European population. AIM: This research sought to further cross-validate the measure in a non-clinical Irish adolescent sample, and to test for gender and age-based differential item functioning in depression and anxiety. METHOD: Participants were Irish second-level school students (N = 345; 164 male; 12-18 years, M =14...
February 15, 2018: Journal of Mental Health
https://www.readbyqxmd.com/read/29444830/characterization-of-a-vesivirus-associated-with-an-outbreak-of-acute-hemorrhagic-gastroenteritis-in-domestic-dogs
#7
Randall W Renshaw, Jennifer Griffing, Jaime Weisman, Lisa M Crofton, Melissa A Laverack, Robert P Poston, Gerald E Duhamel, Edward J Dubovi
Four out of eleven affected dogs died despite aggressive treatment during a 2015 focal outbreak of hemorrhagic gastroenteritis following a stay in a pet housing facility. Routine diagnostic investigations failed to identify a specific cause. Virus isolation from fresh necropsy tissues yielded a calicivirus with sequence homology to a vesivirus within the group colloquially known as the 2117 strains that were originally identified as contaminants in CHO cell bioreactors. In situ hybridization and reverse transcription-PCR assays of tissues from the four deceased dogs confirmed the presence of canine vesivirus (CaVV) nucleic acids that localized to endothelial cells of arterial and capillary blood vessels...
February 14, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29444152/the-interaction-between-cannabis-use-and-the-val158met-polymorphism-of-the-comt-gene-in-psychosis-a-transdiagnostic-meta-analysis
#8
Thomas Stephanus Johannes Vaessen, Lea de Jong, Annika Theresia Schäfer, Thomas Damen, Aniek Uittenboogaard, Pauline Krolinski, Chinyere Vicky Nwosu, Florentina Maria Egidius Pinckaers, Iris Leah Marije Rotee, Antonius Petrus Wilhelmus Smeets, Ayşegül Ermiş, James L Kennedy, Dorien H Nieman, Arun Tiwari, Jim van Os, Marjan Drukker
BACKGROUND: Neither environmental nor genetic factors are sufficient to predict the transdiagnostic expression of psychosis. Therefore, analysis of gene-environment interactions may be productive. OBJECTIVE: A meta-analysis was performed using papers investigating the interaction between cannabis use and catechol-O-methyl transferase (COMT) polymorphism Val158Met (COMTVal158Met). DATA SOURCES: PubMed, Embase, PsychInfo. STUDY ELIGIBILITY CRITERIA: All observational studies assessing the interaction between COMTVal158Met and cannabis with any psychosis or psychotic symptoms measure as an outcome...
2018: PloS One
https://www.readbyqxmd.com/read/29442206/thrown-into-the-world-of-independent-practice-from-unexpected-uncertainty-to-new-identities
#9
Brett Schrewe
One of the most exciting yet stressful times in a physician's life is transitioning from supervised training into independent practice. The majority of literature devoted to this topic has focused upon a perceived gap between clinical and non-clinical skills and interventions taken to address it. Building upon recent streams of scholarship in identity formation and adaptation to new contexts, this work uses a Heideggerian perspective to frame an autoethnographical exploration of the author's transition into independent paediatric practice...
February 13, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29440464/outcome-measures-in-coeliac-disease-trials-the-tampere-recommendations
#10
Jonas F Ludvigsson, Carolina Ciacci, Peter Hr Green, Katri Kaukinen, Ilma R Korponay-Szabo, Kalle Kurppa, Joseph A Murray, Knut Erik Aslaksen Lundin, Markku J Maki, Alina Popp, Norelle R Reilly, Alfonso Rodriguez-Herrera, David S Sanders, Detlef Schuppan, Sarah Sleet, Juha Taavela, Kristin Voorhees, Marjorie M Walker, Daniel A Leffler
OBJECTIVE: A gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies. We aimed to review the literature on coeliac disease therapeutic trials and issue recommendations for outcome measures. DESIGN: Based on a literature review of 10 062 references, we (17 researchers and 2 patient representatives from 10 countries) reviewed the use and suitability of both clinical and non-clinical outcome measures...
February 13, 2018: Gut
https://www.readbyqxmd.com/read/29439664/heart-rate-defined-sustained-attention-in-infants-at-risk-for-autism
#11
Bridgette L Tonnsen, John E Richards, Jane E Roberts
BACKGROUND: Although aberrant visual attention has been identified in infants at high familial risk for autism, the developmental emergence of atypical attention remains unclear. Integrating biological measures of attention into prospective high-risk infant studies may inform more nuanced developmental trajectories, clarifying the onset and course of atypical attention and potentially advancing early screening or treatment protocols. Heart rate-defined sustained attention (HRDSA) is a well-validated biological measure of attentional engagement that, in non-clinical infant populations, provides incremental information about attentional engagement beyond looking behaviors alone...
February 13, 2018: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29434562/latent-profile-analysis-of-schizotypy-and-paranormal-belief-associations-with-probabilistic-reasoning-performance
#12
Andrew Denovan, Neil Dagnall, Kenneth Drinkwater, Andrew Parker
This study assessed the extent to which within-individual variation in schizotypy and paranormal belief influenced performance on probabilistic reasoning tasks. A convenience sample of 725 non-clinical adults completed measures assessing schizotypy (Oxford-Liverpool Inventory of Feelings and Experiences; O-Life brief), belief in the paranormal (Revised Paranormal Belief Scale; RPBS) and probabilistic reasoning (perception of randomness, conjunction fallacy, paranormal perception of randomness, and paranormal conjunction fallacy)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29429046/yoga-and-immune-system-functioning-a-systematic-review-of-randomized-controlled-trials
#13
REVIEW
R I Falkenberg, C Eising, M L Peters
Yoga is an ancient mind-body practice that is increasingly recognized to have health benefits in a variety of clinical and non-clinical conditions. This systematic review summarizes the findings of randomized controlled trials examining the effects of yoga on immune system functioning which is imperative to justify its application in the clinic. Fifteen RCTs were eligible for the review. Even though the existing evidence is not entirely consistent, a general pattern emerged suggesting that yoga can downregulate pro-inflammatory markers...
February 10, 2018: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29429039/health-survey-of-adults-with-neurofibromatosis-1-compared-to-population-study-controls
#14
Krister W Fjermestad, Livø Nyhus, Øivind J Kanavin, Arvid Heiberg, Lise B Hoxmark
Neurofibromatosis type 1 (NF1) is a genetic, autosomal dominant multi-organ disease characterized by susceptibility to tumor formation, changes in skin pigmentation, skeletal abnormalities, and neuropsychological deficits. Clinical studies have shown impaired health-related quality of life (HQoL) in adults with NF1. However, little is known about HQoL in non-clinical NF1 samples. We conducted a cross-sectional self-report survey of 142 persons with NF1 (M age = 50.3 years, SD = 12.0, range 32 to 80; 62...
February 10, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29427652/evaluating-the-abuse-potential-of-psychedelic-drugs-for-medical-use-in-humans
#15
REVIEW
David J Heal, Jane Gosden, Sharon L Smith
Psychedelics comprise drugs come from various pharmacological classes including 5-HT 2A agonists, indirect 5-HT agonists, e.g. MDMA, NMDA antagonists and κ-opioid receptor agonists. There is resurgence in developing psychedelics to treat psychiatric disorders with high unmet clinical need. Many, but not all, psychedelics are schedule 1 controlled drugs (CDs), i.e. no approved medical use. For existing psychedelics in development, regulatory approval will require a move from schedule 1 to a CD schedule for drugs with medical use, i...
February 7, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29425951/a-novel-approach-to-challenging-ocd-related-beliefs-using-a-mobile-app-an-exploratory-study
#16
María Roncero, Amparo Belloch, Guy Doron
BACKGROUND AND OBJECTIVES: According to cognitive models, obsessive compulsive symptoms result from catastrophic misinterpretations of commonly occurring intrusive experiences and the use of counterproductive strategies to manage them. Obsessive Compulsive Disorder (OCD) related beliefs such as inflated responsibility, importance of thoughts and perfectionism increases the likelihood of such misinterpretations. Consistent with a growing body of literature supporting the usefulness of mobile delivered technologies in fostering cognitive behavior change, the present study assessed the effectiveness of a novel cognitive training exercise designed to challenge OCD-related beliefs...
February 2, 2018: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29425218/body-size-estimation-of-self-and-others-in-females-varying-in-bmi
#17
Anne Thaler, Michael N Geuss, Simone C Mölbert, Katrin E Giel, Stephan Streuber, Javier Romero, Michael J Black, Betty J Mohler
Previous literature suggests that a disturbed ability to accurately identify own body size may contribute to overweight. Here, we investigated the influence of personal body size, indexed by body mass index (BMI), on body size estimation in a non-clinical population of females varying in BMI. We attempted to disentangle general biases in body size estimates and attitudinal influences by manipulating whether participants believed the body stimuli (personalized avatars with realistic weight variations) represented their own body or that of another person...
2018: PloS One
https://www.readbyqxmd.com/read/29424087/can-you-detect-early-dementia-from-an-email-a-proof-of-principle-study-of-daily-computer-use-to-detect-cognitive-and-functional-decline
#18
G Stringer, S Couth, L J E Brown, D Montaldi, A Gledson, J Mellor, A Sutcliffe, P Sawyer, J Keane, C Bull, X Zeng, P Rayson, I Leroi
OBJECTIVE: To determine whether multiple computer use behaviours can distinguish between cognitively healthy older adults and those in the early stages of cognitive decline, and to investigate whether these behaviours are associated with cognitive and functional ability. METHODS: Older adults with cognitive impairment (n = 20) and healthy controls (n = 24) completed assessments of cognitive and functional abilities and a series of semi-directed computer tasks...
February 9, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29421368/construct-validation-of-the-hybrid-model-of-posttraumatic-stress-disorder-distinctiveness-of-the-new-symptom-clusters
#19
Madison W Silverstein, Nathalie Dieujuste, Lindsay B Kramer, Daniel J Lee, Frank W Weathers
Despite the factor analytic support for the seven-factor hybrid model (Armour et al., 2015) of posttraumatic stress disorder (PTSD), little research has examined the degree to which newly established symptom clusters (i.e., negative affect, anhedonia, dysphoric arousal, anxious arousal, externalizing behavior) functionally and meaningfully differ in their associations with other clinical phenomena. The aim of the current study was to examine the degree to which newly established PTSD symptom clusters differentially relate to co-occurring psychopathology and related clinical phenomena through Wald testing using latent variable modeling...
December 30, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29416152/a-prospective-observational-study-comparing-criteria-based-discharge-method-with-traditional-time-based-discharge-method-for-discharging-patients-from-post-anaesthesia-care-unit-undergoing-ambulatory-or-outpatient-minor-surgeries-under-general-anaesthesia
#20
Anuj Jain, Varadarajan Muralidhar, Sanjeev Aneja, Anil Kumar Sharma
Background and Aims: Mostly, institutions in India have single post-anaesthesia care unit (PACU) which follows traditional time-based discharge (TBD) method. Recently, it has been classified into PACU Phase I and Phase II, and criteria-based discharge (CBD) method has been used. This study primarily compares CBD versus TBD methods in moving patients through PACU, and other non-clinical factors causing delay in shifting. Methods: One hundred patients, aged 18-65 years, American Society of Anesthesiologist's physical status I and II, scheduled for elective minor surgeries under general anaesthesia were studied...
January 2018: Indian Journal of Anaesthesia
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