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https://www.readbyqxmd.com/read/28641134/adverse-childhood-experiences-ace-and-adult-attachment-interview-aai-in-a-non-clinical-population
#1
Paula Thomson, S Victoria Jaque
Adverse childhood experiences (ACE) tend to be interrelated rather than independently occurring. There is a graded effect associated with ACE exposure and pathology, with an increase when ACE exposure is four or more. This study examined a sample of active individuals (n=129) to determine distribution patterns and relationships between ACEs, attachment classification, unresolved mourning (U), and disclosure difficulty. The results of this study demonstrated a strong relationship between increased ACEs and greater unresolved mourning...
June 19, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28636280/getting-on-the-same-page-communication-patient-involvement-and-shared-understanding-of-decisions-in-oncology
#2
Aaron L Leppin, Marleen Kunneman, Julie Hathaway, Cara Fernandez, Victor M Montori, Jon C Tilburt
BACKGROUND: Patients and clinicians do not often agree on whether a decision has been made about cancer care. This could be explained by factors related to communication quality and/or the type of decision being made. METHODS: We used a self-developed coding scheme to code a random sample of 128 encounters in which patients and clinicians either agreed (n=64) or disagreed (n=64) that a cancer care decision was made and tested for associations between concordance and key communication behaviours...
June 21, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28634459/cognitive-correlates-of-different-mentalizing-abilities-in-individuals-with-high-and-low-trait-schizotypy-findings-from-an-extreme-group-design
#3
Krisztina Kocsis-Bogár, Simone Kotulla, Susanne Maier, Martin Voracek, Kristina Hennig-Fast
Mentalizing or Theory of Mind (ToM) deficits in schizophrenia have been studied to great extent, but studies involving samples of trait schizotypy yield ambiguous results. Executive functions like cognitive inhibition, cognitive flexibility, and agency are all prerequisites of mentalizing, and it is assumed that the impairment of these functions contributes to ToM deficits in schizophrenia. Whether these impairments influence the ToM performance of people with high trait schizotypy remains unclear. Although impaired self-agency has repeatedly been identified in people with schizotypy, its role in mentalizing is yet to be investigated...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28634147/csahi-study-2-validation-of-multi-electrode-array-systems-mea60-2100-for-prediction-of-drug-induced-proarrhythmia-using-human-ips-cell-derived-cardiomyocytes-assessment-of-reference-compounds-and-comparison-with-non-clinical-studies-and-clinical-information
#4
Yumiko Nozaki, Yayoi Honda, Hitoshi Watanabe, Shota Saiki, Kiyotaka Koyabu, Tetsuji Itoh, Chiho Nagasawa, Chiaki Nakamori, Chiaki Nakayama, Hiroshi Iwasaki, Shinobu Suzuki, Kohji Tanaka, Etsushi Takahashi, Kaori Miyamoto, Kaoru Morimura, Atsuhiro Yamanishi, Hiroko Endo, Junko Shinozaki, Hisashi Nogawa, Tadahiro Shinozawa, Fumiyo Saito, Takeshi Kunimatsu
With the aim of reconsidering ICH S7B and E14 guidelines, a new in vitro assay system has been subjected to worldwide validation to establish a better prediction platform for potential drug-induced QT prolongation and the consequent TdP in clinical practice. In Japan, CSAHi HEART team has been working on hiPS-CMs in the MEA (hiPS-CMs/MEA) under a standardized protocol and found no inter-facility or lot-to-lot variability for proarrhythmic risk assessment of 7 reference compounds. In this study, we evaluated the responses of hiPS-CMs/MEA to another 31 reference compounds associated with cardiac toxicities, and gene expression to further clarify the electrophysiological characteristics over the course of culture period...
June 17, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28628809/distrust-of-the-senses-and-its-association-with-obsessive-compulsive-symptoms
#5
Shiu F Wong, Alishia D Williams, Jessica R Grisham
BACKGROUND AND OBJECTIVES: Leading cognitive theories of OCD suggests that despite prevalent and persistent doubt, individuals with OCD do not have perceptual deficits. An alternate cognitive theory, the Seeking Proxies for Internal States hypothesis (SPIS), proposes that sensory distrust in OCD stems from actual deficits in accessing internal states. Consistent with the SPIS, previous research has found that high-OC individuals were less accurate than low-OC individuals in producing target levels of muscle tension in a biofeedback task and that OC symptoms were positively associated with reliance on an external proxy...
June 13, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28624678/the-relationships-between-father-involvement-and-parental-acceptance-on-the-psychological-adjustment-of-children-and-adolescents-the-moderating-effects-of-clinical-status
#6
Mercedes Rodríguez Ruiz, Francisco Pablo Holgado-Tello, Miguel Ángel Carrasco
This study analyzes how a child's clinical condition modifies the relationship of father involvement, parental (fathers and mothers) acceptance and the child´s psychological adjustment, including the internalizing and externalizing problems. The cohort studied was composed of 226 subjects (61.94% males) with a mean age of 14.08 years, of which 113 children were from an incidental clinical sample and 113 from the general population. Both groups were matched by sex, age and family status, and the data show that the same structure of parent-child relationships that predict the child´s psychological adjustment can be accepted for both the clinical and non-clinical groups of children...
June 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28620503/general-practice-views-of-managing-childhood-obesity-in-primary-care-a-qualitative-analysis
#7
Jennifer E O'Donnell, Rachel Foskett-Tharby, Paramjit S Gill
OBJECTIVE: To explore general practice staff views of managing childhood obesity in primary care. DESIGN: A qualitative study to elicit the views of clinical and non-clinical general practice staff on managing childhood obesity. SETTING: Interviews were conducted at 30 general practices across England. These practices were interviewed as part of the Quality and Outcomes Framework Pilot Study. PARTICIPANTS: A total of 52 staff from 30 practices took part in a semi-structured interview...
June 2017: JRSM Open
https://www.readbyqxmd.com/read/28616683/general-practitioners-perceptions-of-the-current-status-and-pharmacists-contribution-to-primary-care-in-iceland
#8
Anna Bryndis Blondal, Jon Steinar Jonsson, Sofia Kälvemark Sporrong, Anna Birna Almarsdottir
Background For the past several years pharmacists' responsibilities have expanded globally from traditional tasks of dispensing medications to collaborating with other health care professionals in patient care. Similar developments have not occurred in outpatient settings in Iceland. Objective The aim of this study was to explore Icelandic general practitioners' views on the current status of primary care, their perceptions of pharmacists as a health care profession, and their attitudes towards future GP-pharmacist collaboration in primary care in Iceland...
June 14, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28614379/microbiome-restoration-diet-improves-digestion-cognition-and-physical-and-emotional-wellbeing
#9
Kate Lawrence, Jeannette Hyde
Manipulating gut bacteria in the microbiome, through the use of probiotics and prebiotics, has been found to have an influence on both physical and emotional wellbeing. This study uses a dietary manipulation 'The Gut Makeover' designed to elicit positive changes to the gut bacteria within the microbiome. 21 healthy participants undertook 'The Gut Makeover' for a four week period. Weight and various aspects of health were assessed pre and post intervention using the Functional Medicine Medical Symptoms Questionnaire (MSQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28612643/survey-of-irish-general-practitioners-preferences-for-continuing-professional-development
#10
B Maher, R O'Neill, A Faruqui, C Bergin, M Horgan, D Bennett, C M P O'Tuathaigh
BACKGROUND: Doctors' continuing professional development (CPD) training needs are known to be strongly influenced by national and local contextual characteristics. Given the changing national demographic profile and government-mandated changes to primary care health care provision, this study aimed to investigate Irish General Practitioners' (GPs) perceptions of, and preferences for, current and future CPD programmes. METHODS: A cross-sectional questionnaire, using closed- and open-ended questions, was administered to Irish GPs, focusing on training needs analysis; CPD course content; preferred format and the learning environment...
June 14, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28612082/reaching-out-for-help-an-analysis-of-the-differences-between-refugees-who-accept-and-those-who-decline-community-mental-health-services
#11
Jennifer L Ballard-Kang, Thomas R Lawson, Jane Evans
In 2012, clinics in Louisville, Kentucky began to use the RHS-15 to screen for mental health issues among refugees. At the same time, mental health outreach programs were developed and implemented by the Mental Health Coordinator. Data from 563 refugee clients referred to the Mental Health Coordinator from 2012 to 2015 was analyzed to examine differences between refugees who accepted referral to community mental health services and those who declined on the variables age, gender, country of origin, time in the U...
June 13, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28611690/rethinking-a-negative-event-the-affective-impact-of-ruminative-versus-imagery-based-processing-of-aversive-autobiographical-memories
#12
Christien Slofstra, Maarten C Eisma, Emily A Holmes, Claudi L H Bockting, Maaike H Nauta
INTRODUCTION: Ruminative (abstract verbal) processing during recall of aversive autobiographical memories may serve to dampen their short-term affective impact. Experimental studies indeed demonstrate that verbal processing of non-autobiographical material and positive autobiographical memories evokes weaker affective responses than imagery-based processing. In the current study, we hypothesized that abstract verbal or concrete verbal processing of an aversive autobiographical memory would result in weaker affective responses than imagery-based processing...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28608402/does-the-severity-of-psychopathology-of-italian-students-receiving-counselling-services-increase-over-time-a-5-year-analysis-and-a-comparison-with-a-clinical-and-non-clinical-sample
#13
Maria Grazia Strepparava, Marco Bani, Federico Zorzi, Umberto Mazza, Francesca Barile, Giorgio Rezzonico
Psychological problems-from the most minor such as exams anxiety to the more severe such as personality disorders-are not rare in young adults. University Counselling Services often present the only opportunity for undergraduates to meet health professionals and to be confronted with their difficulties in a non-clinical setting or-in cases of more severe psychopathology-to be referred to mental health services. Recent research attests to the increasing severity of psychological problems among undergraduate and graduate university students...
June 13, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28606478/withdrawal-of-inhaled-corticosteroids-in-copd-a-meta-analysis
#14
Luigino Calzetta, Maria Gabriella Matera, Fulvio Braido, Marco Contoli, Angelo Corsico, Fabiano Di Marco, Pierachille Santus, Nicola Scichilone, Mario Cazzola, Paola Rogliani
BACKGROUND: Conflicting findings exist on the benefit of withdrawal of inhaled corticosteroid (ICS) in chronic obstructive pulmonary disease (COPD). We performed a quantitative synthesis in order to assess real impact of ICS discontinuation in COPD patients. METHODS: We carried out a meta-analysis via random-effects model on the available clinical evidence to evaluate the effect of ICS discontinuation in COPD. Randomized clinical trials and observational real-life studies investigating the effects of ICS withdrawal on the risk of COPD exacerbation, lung function (forced expiratory volume in 1 s [FEV1]) and quality of life (St...
June 9, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28605709/facial-emotion-recognition-and-borderline-personality-pathology
#15
Kevin B Meehan, Chiara De Panfilis, Nicole M Cain, Camilla Antonucci, Antonio Soliani, John F Clarkin, Fabio Sambataro
The impact of borderline personality pathology on facial emotion recognition has been in dispute; with impaired, comparable, and enhanced accuracy found in high borderline personality groups. Discrepancies are likely driven by variations in facial emotion recognition tasks across studies (stimuli type/intensity) and heterogeneity in borderline personality pathology. This study evaluates facial emotion recognition for neutral and negative emotions (fear/sadness/disgust/anger) presented at varying intensities...
May 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28604925/association-of-adverse-events-with-antibiotic-use-in-hospitalized-patients
#16
Pranita D Tamma, Edina Avdic, David X Li, Kathryn Dzintars, Sara E Cosgrove
Importance: Estimates of the incidence of overall antibiotic-associated adverse drug events (ADEs) in hospitalized patients are generally unavailable. Objective: To describe the incidence of antibiotic-associated ADEs for adult inpatients receiving systemic antibiotic therapy. Design, Setting, and Participants: Retrospective cohort of adult inpatients admitted to general medicine wards at an academic medical center. Exposures: At least 24 hours of any parenteral or oral antibiotic therapy...
June 12, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28601693/causal-role-for-inverse-reasoning-on-obsessive-compulsive-symptoms-preliminary-evidence-from-a-cognitive-bias-modification-for-interpretation-bias-study
#17
Shiu F Wong, Jessica R Grisham
BACKGROUND AND OBJECTIVES: The inference-based approach (IBA) is a cognitive account of the genesis and maintenance of obsessive-compulsive disorder (OCD). According to the IBA, individuals with OCD are prone to using inverse reasoning, in which hypothetical causes form the basis of conclusions about reality. Several studies have provided preliminary support for an association between features of the IBA and OCD symptoms. However, there are currently no studies that have investigated the proposed causal relationship of inverse reasoning in OCD...
June 3, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28601498/self-reported-cognitive-distortions-in-the-psychosis-continuum-a-polish-18-item-version-of-the-davos-assessment-of-cognitive-biases-scale-dacobs-18
#18
Łukasz Gawęda, Katarzyna Prochwicz, Martyna Krężołek, Joanna Kłosowska, Maciej Staszkiewicz, Steffen Moritz
AIM: The aim of this study was to provide a short version of the Davos Assessment of Cognitive Biases Scale (DACOBS), which is a self-report tool to assess cognitive distortions related to psychosis. METHODS: A principal component analysis (PCA) was conducted on a large non-clinical sample (n=1207) and cross-validated with a confirmatory factor analysis on an independent non-clinical sample (n=653). Discriminative validity was performed by contrasting the high risk for psychosis non-clinical sample (n=63), low risk for psychosis non-clinical sample (n=152), patients with schizophrenia (n=105), and patients with depression (n=56)...
June 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28601196/pilot-study-into-milk-haptoglobin-as-an-indicator-of-udder-health-in-heifers-after-calving
#19
P B A Simões, M Campbell, L Viora, J Gibbons, T E Geraghty, P D Eckersall, R N Zadoks
Mastitis, inflammation of the mammary gland, is often caused by intramammary infection with bacterial organisms. It impacts on dairy cattle welfare, production, udder health and longevity in the herd. Current detection methods for mammary inflammation and infection all have limitations, particularly for on-farm diagnosis of non-clinical mastitis after calving. Acute phase proteins have been suggested as alternative early indicators of the disease and can potentially be used as cow-side test with results in real time...
May 23, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28600932/investigation-of-associations-between-attachment-parenting-and-schizotypy-during-the-postnatal-period
#20
Melanie Hugill, Ian Fletcher, Katherine Berry
BACKGROUND: Parenting can be a stressful experience particularly for people with mental health problems or people who experienced abuse or attachment difficulties in their own childhoods. This study examined the relationships between earlier trauma, attachment, parenting and schizotypy in a non-clinical sample, with the specific hypothesis that parenting stress and competence would mediate any association between trauma, attachment and schizotypy. METHODS: One hundred and thirty-four first time parents with a child under 12 months old completed the following questionnaires online: the Experiences of Close Relationships Scale - Short Form (ECR-S), the Schizotypal Personality Questionnaire - Brief, Revised (SPQ-BR) the Parenting Stress Scale, the Parenting Sense of Competence Scale (PSOC) and the Adverse Childhood Experiences (ACE) Questionnaire...
May 31, 2017: Journal of Affective Disorders
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