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https://www.readbyqxmd.com/read/28079671/outcomes-of-exercise-training-following-the-use-of-a-birthing-ball-during-pregnancy-and-delivery
#1
Danielle Fournier, Gloria Feeney, Marie-Eve Mathieu
INTRODUCTION: Using a birthing ball (BB) is an exercise form that is growing in popularity. Improved delivery outcomes have been recently reported with as little a 6-8 hours of training per week; however, little is known regarding lower and higher training levels. The aim of the current study was to document whether more time spent training with a BB resulted in improved delivery outcomes for the mother and the newborn. METHODS: This quasi-experimental study was conducted with a sample of women who participated in one to 28 supervised exercise classes during pregnancy according to the Ballon Forme program offered in non-clinical settings (http://ballonforme...
January 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28078124/advanced-biliary-tract-cancer-clinical-outcomes-with-abc-02-regimen-and-analysis-of-prognostic-factors-in-a-tertiary-care-center-in-the-united-states
#2
Rishi Agarwal, Arun Sendilnathan, Nabeela Iffat Siddiqi, Shuchi Gulati, Abhimanyu Ghose, Changchun Xie, Olugbenga Olanrele Olowokure
BACKGROUND: Gemcitabine plus cisplatin (GC) is currently the standard regimen for advanced biliary tract cancers (BTC) based on the outcomes in ABC-02 trial. Multiple factors can affect outcomes in these patients. This retrospective review evaluates the University of Cincinnati experience with GC in advanced intrahepatic (IHC)/extrahepatic cholangiocarcinoma (EHC) and gall bladder carcinoma (GBC). METHODS: In this study approved by University of Cincinnati IRB, retrospective analysis of advanced BTC patients seen between 01/2008 and 01/2015 was done...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28078089/the-specificity-of-emotion-dysregulation-in-adolescents-with-borderline-personality-disorder-comparison-with-psychiatric-and-healthy-controls
#3
Marina Ibraheim, Allison Kalpakci, Carla Sharp
BACKGROUND: Research has supported the notion that emotion dysregulation is a core feature of BPD. However, given that this feature is typical of healthy adolescents as well as adolescents with other psychiatric disorders, the specificity of emotion dysregulation to BPD in this age group has not yet been determined. The overall aim of this study was to examine emotion dysregulation in adolescent inpatients with BPD compared with non-BPD inpatient adolescents and healthy non-clinical adolescents, taking into account both global emotion dysregulation deficits and more specific impairments...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28077000/specificity-rates-for-non-clinical-bilingual-mexican-americans-on-three-popular-performance-validity-measures
#4
Philip G Gasquoine, Amy A Weimer, Arnoldo Amador
OBJECTIVE: To measure specificity as failure rates for non-clinical, bilingual, Mexican Americans on three popular performance validity measures: (a) the language format Reliable Digit Span; (b) visual-perceptual format Test of Memory Malingering; and (c) visual-perceptual format Dot Counting, using optimal/suboptimal effort cut scores developed for monolingual, English-speakers. METHODS: Participants were 61 consecutive referrals, aged between 18 and 65 years, with <16 years of education who were subjectively bilingual (confirmed via formal assessment) and chose the language of assessment, Spanish or English, for the performance validity tests...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28074265/pharmacokinetic-and-exposure-response-analyses-of-pertuzumab-in-combination-with-trastuzumab-and-docetaxel-during-neoadjuvant-treatment-of-her2-%C3%A2-early-breast-cancer
#5
Angelica L Quartino, Hanbin Li, Jin Y Jin, D Russell Wada, Mark C Benyunes, Virginia McNally, Lucia Viganò, Ihsan Nijem, Bert L Lum, Amit Garg
PURPOSE: The NeoSphere trial evaluated pertuzumab in the neoadjuvant setting [early breast cancer (EBC)] with pathological complete response (pCR) as the primary efficacy end point. This analysis of pertuzumab aimed to (1) compare its pharmacokinetics (PK) in patients with EBC versus advanced cancers, (2) to further evaluate PK drug-drug interactions (DDIs) when given in combination with trastuzumab, and (3) to assess the relationship between exposure and efficacy to assess the clinical dosing regimen in the EBC patients...
January 10, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28073345/reasons-for-faculty-departures-from-an-academic-medical-center-a-survey-and-comparison-across-faculty-lines
#6
Sabine C Girod, Magali Fassiotto, Roseanne Menorca, Henry Etzkowitz, Sherry M Wren
BACKGROUND: Faculty departure can present significant intellectual costs to an institution. The authors sought to identify the reasons for clinical and non-clinical faculty departures at one academic medical center (AMC). METHOD: In May and June 2010, the authors surveyed 137 faculty members who left a west coast School of Medicine (SOM) between 1999 and 2009. In May and June 2015, the same survey was sent to 40 faculty members who left the SOM between 2010-2014, for a total sample size of 177 former faculty members...
January 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28070762/being-on-your-own-or-feeling-lonely-loneliness-and-other-social-variables-in-youths-with-autism-spectrum-disorders
#7
Anne Deckers, Peter Muris, Jeffrey Roelofs
A cross-sectional study was conducted to examine loneliness and its correlates in children (7 to 11 years) and adolescents (12 to 18 years) with autism spectrum disorders (ASD, n = 73) and control groups of clinically referred (ADHD, n = 76) and non-clinical (n = 106) youths. Youths completed questionnaires on loneliness and desire for social interaction, while parents and teachers filled out scales on other aspects of children's social functioning. Results indicated that only at an adolescent age, the ASD group reported higher levels of loneliness than the control groups...
January 9, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28070113/pharmacological-characterization-of-microminipig-as-a-model-to-assess-the-drug-induced-cardiovascular-responses-for-non-clinical-toxicity-and-or-safety-pharmacology-studies
#8
Hirofumi Yokoyama, Yuji Nakamura, Hiroyuki Saito, Yukitoshi Nagayama, Kiyotaka Hoshiai, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Yasuki Akie, Atsushi Sugiyama
We tried to establish the halothane-anesthetized microminipigs as an alternative animal model for non-clinical toxicity and/or safety pharmacology studies. In order to characterize the halothane-anesthetized microminipigs, we firstly clarified the effects of halothane anesthesia on their cardiovascular system (n = 5). Then, we examined the cardiovascular effects of dl-sotalol in doses of 0.1, 0.3 and 1 mg/kg, i.v. on the halothane-anesthetized microminipigs (n = 6). Induction of the halothane anesthesia by itself prolonged the QT interval as well as QTcF, suggesting that the halothane anesthesia can reduce the cardiac repolarization reserve in microminipigs like in dogs...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28065821/an-evaluation-of-the-utility-of-lvdp-dt40-qa-interval-lvdp-dtmin-and-tau-as-indicators-of-drug-induced-changes-in-contractility-and-lusitropy-in-dogs
#9
Michael K Pugsley, Brian Guth, Alan Y Chiang, Jennifer M Doyle, Michael Engwall, Jean-Michel Guillon, Peter K Hoffmann, John E Koerner, Scott W Mittelstadt, Jennifer Beck Pierson, Eric I Rossman, R Dustan Sarazan, Stan Parish
INTRODUCTION: The importance of drug-induced effects on the inotropic state of the heart is well known.Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety testing for years, the non-clinical assessment of drug effects on myocardial contractility is used less frequently with no established translation to humans. The goal of these studies was to determine whether assessment of alternate measures of cardiac inotropy could detect drug-induced changes in the contractile state of the heart using drugs known to have clinically relevant positive and negative effects on myocardial contractility...
January 5, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28062651/an-activist-s-argument-that-participant-values-should-guide-risk-benefit-ratio-calculations-in-hiv-cure-research
#10
David Evans
The patient empowerment movement, spurred by AIDS activism in the 1980s, quickly evolved to encompass how study participants are considered and treated in clinical research. Initially, people fearing death of AIDS sought early access to experimental medications that had not undergone rigorous testing in hopes of extending their lives. Thirty years on, scientists are asking a different set of ethical questions about clinical research, this time in the pursuit of either a sterilising cure or long-term remission for HIV...
January 6, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28060313/generation-of-human-monocyte-derived-dendritic-cells-from-whole-blood
#11
Wilfried Posch, Cornelia Lass-Flörl, Doris Wilflingseder
Dendritic cells (DCs) recognize foreign structures of different pathogens, such as viruses, bacteria, and fungi, via a variety of pattern recognition receptors (PRRs) expressed on their cell surface and thereby activate and regulate immunity. The major function of DCs is the induction of adaptive immunity in the lymph nodes by presenting antigens via MHC I and MHC II molecules to naïve T lymphocytes. Therefore, DCs have to migrate from the periphery to the lymph nodes after the recognition of pathogens at the sites of infection...
December 24, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059633/adolescent-and-young-adult-women-s-opinions-of-common-eating-disorder-prevention-messages
#12
Jennifer S Mills, Nicole Vu, Ron Manley, Shasha Tse
We examined young women's opinions of five common eating disorder (ED) prevention themes in terms of persuasiveness and impact on behavioral intentions. Video-taped prevention themes were rated by female adolescents and young adults (ages 13-25) with and without eating disorders. Overall, younger participants found the prevention messages less persuasive than older participants. Controlling for age, clinical participants found the messages to be less persuasive than did non-clinical participants. Clinical participants reported no change in their behavioral intentions after watching the videos, whereas non-clinical participants reported a lower intention to diet and make body comparisons after viewing the messages...
January 6, 2017: Eating Disorders
https://www.readbyqxmd.com/read/28057170/can-the-ceiba-cocktail-designed-for-human-cytochrome-p450-enzymes-be-used-in-the-rat-for-drug-interaction-studies
#13
Paulo Magalhães, Fernando De Andrés, Amílcar Falcão, Adrián LLerena, Gilberto Alves
Purpose - The CEIBA cocktail consisting of caffeine (CAF), omeprazole (OZ), dextromethorphan (DM) and losartan (LOS) was previously proposed for the clinical phenotyping of five major human cytochrome P450 (CYP) isoenzymes. This work aimed to assess the usefulness of CEIBA cocktail to study non-clinical drug interactions in the rat. Methods - Wistar rats were divided into five groups to receive a single-oral dose of each probe drug (CAF, OZ, LOS, DM), individually or in combination as a cocktail. Plasma concentrations of the probe drugs and their metabolites [paraxanthine (1,7-X), 5-hydroxyomeprazole (5-OZ), losartan carboxylic acid (E-3174), dextrorphan (DX) and 3-methoxymorphinan (3-MM)] were determined by LC-MS/MS, and the corresponding pharmacokinetic parameters were estimated by non-compartmental analysis...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28050505/assessing-difficulties-encountered-by-dental-students-studying-oral-pathology-and-addressing-their-concerns
#14
Swati Saawarn, Anish Gupta, Megha Jain, Nisheeth Saawarn, Sahana Ashok, K P Ashok, Manish Jain, Nilesh Pardhe
INTRODUCTION: The present scenario of Oral Pathology and Oral Histology as a subject is alarming. In spite of so many advancements in terms of books, internet and conferences there are still lacunae between the understanding and interest for the subjects in the students. It can be partly due to the fact that the students perceive it as a non-clinical subject having a lesser scope for practice. AIM: The present study was aimed at evaluating the students approach towards oral pathology department and the subject...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050336/effects-of-preventive-online-mindfulness-interventions-on-stress-and-mindfulness-a-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
Wasantha P Jayewardene, David K Lohrmann, Ryan G Erbe, Mohammad R Torabi
Empirical evidence suggested that mind-body interventions can be effectively delivered online. This study aimed to examine whether preventive online mindfulness interventions (POMI) for non-clinical populations improve short- and long-term outcomes for perceived-stress (primary) and mindfulness (secondary). Systematic search of four electronic databases, manuscript reference lists, and journal content lists was conducted in 2016, using 21 search-terms. Eight randomized controlled trials (RCTs) evaluating effects of POMI in non-clinical populations with adequately reported perceived-stress and mindfulness measures pre- and post-intervention were included...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28050259/support-for-compassionate-care-quantitative-and-qualitative-evaluation-of-schwartz-center-rounds-in-an-acute-general-hospital
#16
Raymond J Chadwick, Steven J Muncer, Bronagh C Hannon, Joanna Goodrich, Jocelyn Cornwell
OBJECTIVE: To evaluate the impact of Schwartz Center Rounds, a multi-disciplinary forum to reflect on the emotional consequences of working in healthcare, on the staff of a large acute general hospital over a three-year period. DESIGN: Evaluation data following each Round were collected routinely from all staff attending over this period and analysed quantitatively and qualitatively. SETTING: An integrated university teaching trust with both acute hospital and community services in the North East of England...
July 2016: JRSM Open
https://www.readbyqxmd.com/read/28048903/su-f-e-17-a-dedicated-teaching-and-research-linac-as-a-stepping-stone-to-introduce-medical-physics-to-students
#17
L Beaulieu, L Gingras, M Bergeron, L Archambault
PURPOSE: This work describes how a non-clinical, research and teaching Linac is used as an extremely motivating and exciting way to introduce students to medical physics. METHODS: The dedicated facility was inaugurated in 2014. The facility is composed of a fully equipped and functional state-of-the-art Varian TrueBeam Linac and a complete set of physics instruments and QA phantoms for the Linac and onboard imaging. The Linac bunker and treatment console are oversized such that a class of 12-15 can comfortably fit, seated if needed for longer sessions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048199/su-g-brc-15-the-potential-clinical-significance-of-dose-mapping-error-for-intra-fraction-dose-mapping-for-lung-cancer-patients
#18
N Sayah, E Weiss, W Watkins, J Siebers
PURPOSE: To evaluate the dose-mapping error (DME) inherent to conventional dose-mapping algorithms as a function of dose-matrix resolution. METHODS: As DME has been reported to be greatest where dose-gradients overlap tissue-density gradients, non-clinical 66 Gy IMRT plans were generated for 11 lung patients with the target edge defined as the maximum 3D density gradient on the 0% (end of inhale) breathing phase. Post-optimization, Beams were copied to 9 breathing phases...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047723/su-f-t-559-high-resolution-scintillating-fiber-array-for-in-vivo-real-time-srs-and-sbrt-patient-qa
#19
T Knewtson, S Pokhrel, S Loyalka, E Izaguirre
PURPOSE: A high-resolution scintillating fiber detector was built for in-vivo real-time patient specific quality assurance (QA). The detector is designed for stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) to monitor treatment delivery and detect real-time deviations from planned dose to increase patient safety and treatment accuracy. METHODS: The detector consists of two high-density scintillating fiber arrays layered to form an X-Y grid which can be attached to the accessory tray of a medical linac for SBRT and cone SRS treatment QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046532/su-f-t-433-evaluation-of-a-new-dose-mimicking-application-for-clinical-flexibility-and-reliability
#20
D Hoffman, C Kumaran Nair, C Wright, T Yamamoto, J Mayadev, R Valicenti, S Benedict, J Markham, Y Rong
PURPOSE: Clinical workflow and machine down time occasionally require patients to be temporarily treated on a system other than the initial treatment machine. A new commercial dose mimicking application provides automated cross-platform treatment planning to expedite this clinical flexibility. The aim of this work is to evaluate the feasibility of automatic plan creation and establish a robust clinical workflow for prostate and pelvis patients. METHODS: Five prostate and five pelvis patients treated with helical plans were selected for re-planning with the dose mimicking application, covering both simple and complex scenarios...
June 2016: Medical Physics
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