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https://www.readbyqxmd.com/read/29243445/-relationship-between-pre-clinical-toxicity-and-efficacy-of-traditional-chinese-medicine
#1
Yun You, Jian-Rong Li, Fang-Hua Huang, Ling Han
Based on the different category of syndromes between traditional Chinese medicine(TCM) and Western medicine, the relationship between the efficacy and non-clinical toxicity of the TCM was analyzed. If TCM preparations have the same pharmacological targets to treat disease with modern medicine or the Chinese herbal preparations treat the diseases with its toxicity, their toxicity often exhibits the amplification and extension of activity; on the other hand, if TCM preparations have overlapped pharmacological targets but not completely the same with modern medicine, or if they have totally different pharmacological targets, the toxicity of TCM could not be inferred by pharmacological activity...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29243388/the-treatment-outcomes-of-antiretroviral-substitutions-in-routine-clinical-settings-in-asia-data-from-the-treat-asia-hiv-observational-database-tahod
#2
In Young Jung, David Boettiger, Wing Wai Wong, Man Po Lee, Sasisopin Kiertiburanakul, Romanee Chaiwarith, Anchalee Avihingsanon, Junko Tanuma, Nagalingeswaran Kumarasamy, Adeeba Kamarulzaman, Fujie Zhang, Pacharee Kantipong, Oon Tek Ng, Benedict Lim Heng Sim, Matthew Law, Jeremy Ross, Jun Yong Choi
INTRODUCTION: Although substitutions of antiretroviral regimen are generally safe, most data on substitutions are based on results from clinical trials. The objective of this study was to evaluate the treatment outcomes of substituting antiretroviral regimen in virologically suppressed HIV-infected patients in non-clinical trial settings in Asian countries. METHODS: The study population consisted of HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD)...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29242073/abbreviated-atovaquone-proguanil-prophylaxis-regimens-in-travellers-after-leaving-malaria-endemic-areas-a-systematic-review
#3
Jelmer Savelkoel, Klaas Hendrik Binnendijk, Rene Spijker, Michèle van Vugt, Kathrine Tan, Thomas Hänscheid, Patricia Schlagenhauf, Martin Peter Grobusch
BACKGROUND: We evaluated existing data on the prophylactic efficacy of atovaquone-proguanil (AP) in order to determine whether prophylaxis in travellers can be discontinued on the day of return from a malaria-endemic area instead of seven days after return as per currently recommended post-travel schedule. METHODS: PubMed and Embase databases were searched to identify relevant studies. This PROSPERO-registered systematic review followed PRISMA guidelines. The search strategy included terms or synonyms relevant to AP combined with terms to identify articles relating to prophylactic use of AP and inhibitory and half-life properties of AP...
December 11, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29239235/assessing-self-reported-disability-in-a-low-literate-population-with-chronic-low-back-pain-cross-cultural-adaptation-and-psychometric-testing-of-igbo-roland-morris-disability-questionnaire
#4
Chinonso N Igwesi-Chidobe, Chinwe Obiekwe, Isaac O Sorinola, Emma L Godfrey
PURPOSE: Cross-culturally adapt and validate the Igbo Roland Morris Disability Questionnaire. METHOD: Cross-cultural adaptation, test-retest, and cross-sectional psychometric testing. Roland Morris Disability Questionnaire was forward and back translated by clinical/non-clinical translators. An expert committee appraised the translations. Twelve participants with chronic low back pain pre-tested the measure in a rural Nigerian community. Internal consistency using Cronbach's alpha; test-retest reliability using intra-class correlation coefficient and Bland-Altman plot; and minimal detectable change were investigated in a convenient sample of 50 people with chronic low back pain in rural and urban Nigeria...
December 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29238426/wearable-devices-for-caloric-intake-assessment-state-of-art-and-future-developments
#5
REVIEW
Maria Laura Magrini, Clara Minto, Francesca Lazzarini, Matteo Martinato, Dario Gregori
Background: The self-monitoring of caloric intake is becoming necessary as the number of pathologies related to eating increases. New wearable devices may help people to automatically record energy assumed in their meals. Objective: The present review collects the released articles about wearable devices or method for automatic caloric assessments. Method: A literature research has been performed with PubMed, Google Scholar, Scopus and ClinicalTrials...
2017: Open Nursing Journal
https://www.readbyqxmd.com/read/29238308/duration-of-absence-from-work-is-related-to-psychopathology-personality-and-sociodemographic-variables-in-a-longitudinal-cohort
#6
Alex Gamma, Roman Schleifer, Ingeborg Warnke, Vladeta Ajdacic-Gross, Wulf Rössler, Jules Angst, Michael Liebrenz
Objective: To examine, in a non-clinical sample, the association of psychopathology, personality, sociodemographic information, and psychosocial indicators of non-occupational functioning with the duration of absence from work in the past 12 months. Method: A longitudinal community cohort of 591 adults from Switzerland was analyzed using multilevel ordered logistic regression, with several alternative models as robustness checks. Psychopathology was assessed using the total score (Global Severity Index) of the Symptom Check List-90 Revised...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29237051/pharmacist-participation-in-antimicrobial-stewardship-in-australian-and-french-hospitals-a-cross-sectional-nationwide-survey
#7
Naomi Weier, Gianpiero Tebano, Nathalie Thilly, Béatrice Demoré, Céline Pulcini, Syed Tabish R Zaidi
Background: Hospital pharmacists are an integral part of antimicrobial stewardship (AMS) programmes globally. Currently, little is known as to how hospital pharmacists see their role and involvement within the AMS framework. Objectives: To assess the current level of involvement of Australian and French hospital pharmacists in AMS programmes and identify barriers limiting their involvement in AMS. Methods: Hospital pharmacists throughout Australia and France were invited to participate in a nationwide online survey throughout March-May 2016...
December 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29233169/an-evidence-based-gamified-mhealth-intervention-for-overweight-young-adults-with-maladaptive-eating-habits-study-protocol-for-a-randomized-controlled-trial
#8
Ioana R Podina, Liviu A Fodor, Ana Cosmoiu, Rareș Boian
BACKGROUND: Cognitive behavior therapy (CBT) is the first-line of treatment for overweight and obesity patients whose problems originate in maladaptive eating habits (e.g., emotional eating). However, in-person CBT is currently difficult to access by large segments of the population. The proposed SIGMA intervention (i.e., the Self-help, Integrated, and Gamified Mobile-phone Application) is a mHealth intervention based on CBT principles. It specifically targets overweight young adults with underlying maladaptive behaviors and cognitions regarding food...
December 12, 2017: Trials
https://www.readbyqxmd.com/read/29230272/the-role-of-guilt-in-posttraumatic-stress-disorder
#9
Konstantin Bub, Miriam J J Lommen
Background: A growing body of evidence supports the notion that the emotional profile of Posttraumatic Stress Disorder (PTSD) may be more diverse than traditional accounts presume. PTSD's image as an anxiety-based disorder is undergoing change as the significance of other emotions in its development becomes more evident. Experimental research is needed in order to expand the understanding of underlying processes driving the development of PTSD. Objective: Experimentally test the influence of stressor-related guilt on the occurrence of PTSD symptomatology...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29229223/genders-and-individual-treatment-progress-in-non-binary-trans-individuals
#10
Andreas Koehler, Jana Eyssel, Timo O Nieder
BACKGROUND: Health care for transgender and transsexual (ie, trans) individuals has long been based on a binary understanding of gender (ie, feminine vs masculine). However, the existence of non-binary or genderqueer (NBGQ) genders is increasingly recognized by academic and/or health care professionals. AIM: To gain insight into the individual health care experiences and needs of binary and NBGQ individuals to improve their health care outcomes and experience. METHODS: Data were collected using an online survey study on experiences with trans health care...
December 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29229220/relationship-between-attachment-style-and-symptom-severity-across-the-psychosis-spectrum-a-meta-analysis
#11
REVIEW
Sarah Christina Carr, Amy Hardy, Miriam Fornells-Ambrojo
There is growing evidence for the role of attachment in psychosis, however, to date there has been no quantitative review of the prevalence of insecure attachment in psychosis. The current study sought to systematically appraise studies investigating the prevalence of insecure attachment and the association with psychosis-spectrum experiences using meta-analytic techniques. A systematic search of studies carried out between January 1980 and 30th November 2015 found 25 papers eligible for inclusion. The meta-analysis showed that the prevalence of insecure attachment style was significantly higher in individuals with psychosis (76%) than in non-clinical samples (38%), with fearful attachment being the most prevalent...
December 6, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29225263/a-phase-i-ii-study-for-dose-finding-and-to-investigate-the-safety-pharmacokinetics-and-preliminary-efficacy-of-nk012-an-sn-38-incorporating-macromolecular-polymeric-micelle-in-patients-with-multiple-myeloma
#12
Masaki Ri, Kenshi Suzuki, Shinsuke Iida, Kiyohiko Hatake, Takaaki Chou, Masafumi Taniwaki, Noriko Watanabe, Tetsuji Tsukamoto
Objective Multiple myeloma (MM) is the second most common hematological cancer. An attempt to treat MM using a topoisomerase I inhibitor was made based on our previous non-clinical studies suggesting the usefulness of an SN-38 derivative. Our aim was to conduct a phase I/II study of NK012, a micelle-forming SN-38 conjugate, in patients with relapsed/refractory multiple myeloma (RRMM). Methods NK012 was administered at doses of 12-24 mg/m2 and the safety, pharmacokinetics and preliminary efficacy were evaluated...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29223193/quality-indicators-for-evaluating-prehospital-emergency-care-a-scoping-review
#13
Ian Howard, Peter Cameron, Lee Wallis, Maaret Castren, Veronica Lindstrom
Introduction Historically, the quality and performance of prehospital emergency care (PEC) has been assessed largely based on surrogate, non-clinical endpoints such as response time intervals or other crude measures of care (eg, stakeholder satisfaction). However, advances in Emergency Medical Services (EMS) systems and services world-wide have seen their scope and reach continue to expand. This has dictated that novel measures of performance be implemented to compliment this growth. Significant progress has been made in this area, largely in the form of the development of evidence-informed quality indicators (QIs) of PEC...
December 10, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29222971/the-divergent-impact-of-catechol-o-methyltransferase-comt-val158met-genetic-polymorphisms-on-executive-function-in-adolescents-with-discrete-patterns-of-childhood-adversity
#14
Huihui Zhang, Jie Li, Bei Yang, Tao Ji, Zhouting Long, Qiquan Xing, Di Shao, Huayu Bai, Jiwei Sun, Fenglin Cao
PURPOSE: Catechol-O-methyltransferase (COMT) Val158Met functional polymorphisms play a crucial role in the development of executive function (EF), but their effect may be moderated by environmental factors such as childhood adversity. The present study aimed at testing the divergent impact of the COMT Val158Met genotype on EF in non-clinical adolescents with discrete patterns of childhood adversity. METHODS: A total of 341 participants completed the Childhood Trauma Questionnaire, the self-reported version of the Behavior Rating Inventory of Executive Function, and self-administered questionnaires on familial function...
November 22, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29215328/a-realist-evaluation-of-social-prescribing-an-exploration-into-the-context-and-mechanisms-underpinning-a-pathway-linking-primary-care-with-the-voluntary-sector
#15
Marcello Bertotti, Caroline Frostick, Patrick Hutt, Ratna Sohanpal, Dawn Carnes
This article adopts a realist approach to evaluate a social prescribing pilot in the areas of Hackney and City in London (United Kingdom). It unpacks the contextual factors and mechanisms that influenced the development of this pilot for the benefits of GPs, commissioners and practitioners, and reflects on the realist approach to evaluation as a tool for the evaluation of health interventions. Primary care faces considerable challenges including the increase in long-term conditions, GP consultation rates, and widening health inequalities...
December 7, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29205699/use-of-telehealth-in-the-delivery-of-comprehensive-care-for-patients-with-haemophilia-and-other-inherited-bleeding-disorders
#16
REVIEW
R Kulkarni
Advances in technology such as telemedicine (TM) have made access to cost-effective, quality health care feasible for remote patients. TM is especially well suited for patients with chronic disorders such as haemophilia and related haemostatic disorders that benefit not only from more frequent interaction with care providers at a specialized haemophilia treatment center but also from consultations with other specialists. Telehealth refers to a broader application of TM and includes non-clinical services such as education, provider training, administrative meetings etc...
December 5, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29199683/gemcitabine-and-carboplatin-in-metastatic-nonsmall-cell-lung-cancer-experience-from-a-tertiary-cancer-center-in-south-india
#17
T Devika, B Dubashi, D G Shewade, S Kayal, Rcs Kumar
BACKGROUND: Gemcitabine and carboplatin combination is widely used as one of the first-line chemotherapeutic regimens in patients with metastatic nonsmall cell lung cancer patients. METHODOLOGY: A total of 112 patients with metastatic disease were recruited. They were on standard 21-day gemcitabine 1.2 g/m2 and carboplatin AUC 5 dosing schedule. Each patient received at least four cycles and a maximum of 6 cycles of treatment. The patients were followed up, and the demographic, efficacy and toxicity profiles were analyzed...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199063/nanosystems-in-nose-to-brain-drug-delivery-a-review-of-non-clinical-brain-targeting-studies
#18
REVIEW
Patrícia C Pires, Adriana O Santos
The treatment of neurodegenerative and psychiatric disorders remains a challenge in medical research. Several strategies have been developed over the years, either to overcome the blood-brain barrier or to achieve a safer or faster brain delivery, one of them being intranasal (IN) administration. The possibility of direct nose-to-brain transport offers enhanced targeting and reduced systemic side effects. Nevertheless, labile, low soluble, low permeant and/or less potent drugs might need a formulation other than the common solutions or suspensions...
November 30, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29198740/early-transmissible-ampicillin-resistance-in-zoonotic-salmonella-enterica-serotype-typhimurium-in-the-late-1950s-a-retrospective-whole-genome-sequencing-study
#19
Alicia Tran-Dien, Simon Le Hello, Christiane Bouchier, François-Xavier Weill
BACKGROUND: Ampicillin, the first semi-synthetic penicillin active against Enterobacteriaceae, was released onto the market in 1961. The first outbreaks of disease caused by ampicillin-resistant strains of Salmonella enterica serotype Typhimurium were identified in the UK in 1962 and 1964. We aimed to date the emergence of this resistance in historical isolates of S enterica serotype Typhimurium. METHODS: In this retrospective, whole-genome sequencing study, we analysed 288 S enterica serotype Typhimurium isolates collected between 1911 and 1969 from 31 countries on four continents and from various sources including human beings, animals, feed, and food...
November 29, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29198262/medical-missions-for-the-provision-of-paediatric-cardiac-surgery-in-low-and-middle-income-countries
#20
Frank J Molloy, Nguyenvu Nguyen, Marisa Mize, Gavin Wright, Cecilia St George-Hyslop, Maura O'Callaghan, Emma Scanlan, William M Novick
This review will outline the role of visiting cardiac surgical teams in low- and middle-income countries drawing on the collective experience of the authors in a wide range of locations. Requests for assistance can emerge from local programmes at a beginner or advanced stage. However, in all circumstances, careful pre-trip planning is necessary in conjunction with clinical and non-clinical local partners. The clinical evaluation, surgical procedures, and postoperative care all serve as a template for collaboration and education between the visiting and local teams in every aspect of care...
December 2017: Cardiology in the Young
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