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https://www.readbyqxmd.com/read/28096662/synthetic-nanoparticles-of-bovine-serum-albumin-with-entrapped-salicylic-acid
#1
E S Bronze-Uhle, B C Costa, V F Ximenes, P N Lisboa-Filho
Bovine serum albumin (BSA) is highly water soluble and binds drugs or inorganic substances noncovalently for their effective delivery to various affected areas of the body. Due to the well-defined structure of the protein, containing charged amino acids, albumin nanoparticles (NPs) may allow electrostatic adsorption of negatively or positively charged molecules, such that substantial amounts of drug can be incorporated within the particle, due to different albumin-binding sites. During the synthesis procedure, pH changes significantly...
2017: Nanotechnology, Science and Applications
https://www.readbyqxmd.com/read/28092854/biopharmaceutical-characterization-of-praziquantel-cocrystals-and-cyclodextrin-complexes-prepared-by-grinding
#2
Martina Cugovčan, Jasna Jablan, Jasmina Lovrić, Dominik Cinčić, Nives Galić, Mario Jug
Mechanochemical activation using several different co-grinding additives was applied as a green chemistry approach to improve physiochemical and biopharmaceutical properties of praziquantel (PZQ). Liquid assisted grinding with an equimolar amount of citric acid (CA), malic acid (MA), salicylic acid (SA) and tartaric acid (TA) gained in cocrystal formation, which all showed pH-dependent solubility and dissolution rate. However, the most soluble cocrystal of PZQ with MA was chemically unstable, as seen during the stability testing...
January 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28088566/removal-of-salicylic-acid-as-an-emerging-contaminant-by-a-polar-nano-dendritic-adsorbent-from-aqueous-media
#3
M Arshadi, F Mousavinia, M K Abdolmaleki, M J Amiri, A Khalafi-Nezhad
A polar nano-dendritic adsorbent containing amine groups (SAPAMAA) was synthesized onto the nanoparticles of SiO2Al2O3 and its uptake of salicylic acid (SA) from the synthetic and real water was investigated. The synthesized nanomaterials were fully studied by nuclear magnetic resonance spectrum ((1)H NMR and (13)C NMR), Fourier transform infrared spectroscopy (FT-IR), zeta potential (ζ), inductively coupled plasma atomic emission spectroscopy (ICP-AES), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) and elemental analysis...
January 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28078866/favourably-effective-formulation-of-sodium-iodide-and-salicylic-acid-plus-professional-hygiene-in-patients-affected-by-desquamative-gingivitis
#4
P Carcieri, R Broccoletti, S Giacometti, A Gambino, D Conrotto, M Cabras, P G Arduino
The aim of this prospective pilot study was to evaluate the efficiency of an oral hygiene protocol, in combination with a solution of sodium iodide associated to salicylic acid (SISA), in patients affected by desquamative gingivitis (DG). Twenty patients not totally responding to conventional topical therapies, were selected. They received oral hygiene instructions with non-surgical periodontal therapy in a 21-day cohort study (during 3 weekly appointments). The SISA was used at the end of each session, with an impregnated gauze (with 5 ml of the solution) applied for 15 minutes for the upper jaw, and for a further 15 minutes with a new gauze for the lower...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28074489/a-novel-nf-%C3%AE%C2%BAb-inhibitor-edasalonexent-cat-1004-in-development-as-a-disease-modifying-treatment-for-patients-with-duchenne-muscular-dystrophy-phase-1-safety-pharmacokinetics-and-pharmacodynamics-in-adult-subjects
#5
Joanne M Donovan, Michael Zimmer, Elliot Offman, Toni Grant, Michael Jirousek
In Duchenne muscular dystrophy (DMD), NF-κB is activated in skeletal muscle from infancy regardless of the underlying dystrophin mutation and drives inflammation and muscle degeneration while inhibiting muscle regeneration. Edasalonexent (CAT-1004) is a bifunctional orally administered small molecule that covalently links 2 compounds known to inhibit NF-κB, salicylic acid and docosahexaenoic acid (DHA). Edasalonexent is designed to inhibit activated NF-κB upon intracellular cleavage to these bioactive components...
January 11, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28071978/nup82-functions-redundantly-with-nup136-in-a-salicylic-acid-dependent-defense-response-of-arabidopsis-thaliana
#6
Kentaro Tamura, Yoichiro Fukao, Noriyuki Hatsugai, Fumiaki Katagiri, Ikuko Hara-Nishimura
The nuclear pore complex (NPC) comprises more than 30 nucleoporins (Nups). NPC mediates macromolecular trafficking between the nucleoplasm and the cytoplasm, but specific roles of individual Nups are poorly understood in higher plants. Here, we show that the novel nucleoporin unique to angiosperm plants (designated as Nup82) functions in a salicylic acid-dependent defense in a redundant manner with Nup136, which is a component of the nuclear basket in the NPC. Arabidopsis thaliana Nup82 had a similar amino acid sequence to the N-terminal half of Nup136 and a Nup82-GFP fusion was localized on the nuclear envelope...
January 10, 2017: Nucleus
https://www.readbyqxmd.com/read/28070585/effect-of-proline-on-biochemical-and-molecular-mechanisms-in-lettuce-lactuca-sativa-l-exposed-to-uv-b-radiation
#7
Ozkan Aksakal, Dilruba Tabay, Aslıhan Esringu, Feyza Icoglu Aksakal, Nevzat Esim
The purpose of the present study was to evaluate the role of proline (Pro) in relieving UV-B radiation-induced oxidative stress in lettuce. Lettuce seedlings were exposed to 3.3 W m(-2) UV-B radiation for 12 h after pre-treatment sprayed with 20 mM Pro. The data for malondialdehyde (MDA), hydrogen peroxide (H2O2), endogenous Pro level, the activities of antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and peroxidase (POD)], total phenolic concentration, antioxidant capacity, expression of phenylalanine ammonia lyase (PAL), γ-tocopherol methyltransferase (γ-TMT) and proline dehydrogenase (ProDH) genes, phytohormone levels such as abscisic acid (ABA), gibberellic acid (GA), indole acetic acid (IAA) and salicylic acid (SA), soluble sugars and organic acids were recorded...
January 10, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28069610/an-incoherent-feed-forward-loop-mediates-robustness-and-tunability-in-a-plant-immune-network
#8
Akira Mine, Tatsuya Nobori, Maria C Salazar-Rondon, Thomas M Winkelmüller, Shajahan Anver, Dieter Becker, Kenichi Tsuda
Immune signaling networks must be tunable to alleviate fitness costs associated with immunity and, at the same time, robust against pathogen interferences. How these properties mechanistically emerge in plant immune signaling networks is poorly understood. Here, we discovered a molecular mechanism by which the model plant species Arabidopsis thaliana achieves robust and tunable immunity triggered by the microbe-associated molecular pattern, flg22. Salicylic acid (SA) is a major plant immune signal molecule...
January 9, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28068569/quantification-of-ph-dependent-speciation-of-organic-compounds-with-spectroscopy-and-chemometrics
#9
Thomas Ritschel, Kai Uwe Totsche
Fluorescence and UV/Vis spectra of aqueous solutions with numerous organic compounds are a superposition of single spectra of the chemical species present. Thus, an isolation of individual spectra with chemometrics is required for their quantification. We investigated UV/Vis spectra and fluorescence excitation-emission matrices of vanillic acid, salicylic acid, phenoxyacetic acid and phthalic acid with positive matrix factorization (PMF) and non-negativity constrained parallel factor analysis (PARAFAC) in combination with the law of mass action...
December 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/28065923/reduced-susceptibility-of-tomato-stem-to-the-necrotrophic-fungus-botrytis-cinerea-is-associated-with-a-specific-adjustment-of-fructose-content-in-the-host-sugar-pool
#10
François Lecompte, Philippe C Nicot, Julie Ripoll, Manzoor A Abro, Astrid K Raimbault, Félicie Lopez-Lauri, Nadia Bertin
BACKGROUND AND AIMS: Plant soluble sugars, as main components of primary metabolism, are thought to be implicated in defence against pathogenic fungi. However, the function of sucrose and hexoses remains unclear. This study aimed to identify robust patterns in the dynamics of soluble sugars in sink tissues of tomato plants during the course of infection by the necrotrophic fungus Botrytis cinerea Distinct roles for glucose and fructose in defence against B. cinerea were hypothesized. METHODS: We examined sugar contents and defence hormonal markers in tomato stem tissues before and after infection by B...
January 8, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28062592/protein-phosphatase-ap2c1-negatively-regulates-basal-resistance-and-defense-responses-to-pseudomonas-syringae
#11
Volodymyr Shubchynskyy, Justyna Boniecka, Alois Schweighofer, Justinas Simulis, Kotryna Kvederaviciute, Michael Stumpe, Felix Mauch, Salma Balazadeh, Bernd Mueller-Roeber, Freddy Boutrot, Cyril Zipfel, Irute Meskiene
Mitogen-activated protein kinases (MAPKs) mediate plant immune responses to pathogenic bacteria. However, less is known about the cell autonomous negative regulatory mechanism controlling basal plant immunity. We report the biological role of Arabidopsis thaliana MAPK phosphatase AP2C1 as a negative regulator of plant basal resistance and defense responses to Pseudomonas syringae AP2C2, a closely related MAPK phosphatase, also negatively controls plant resistance. Loss of AP2C1 leads to enhanced pathogen-induced MAPK activities, increased callose deposition in response to pathogen-associated molecular patterns or to P...
January 6, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28062367/methods-to-simulate-rubbing-of-topical-formulation-for-in-vitro-skin-permeation-studies
#12
Hiep X Nguyen, Ashana Puri, Ajay K Banga
Rubbing a topical formulation on skin is generally assumed to enhance drug penetration. The aim of this study was to demonstrate different techniques such as using glass rod, rheometer, and gloved finger for rubbing a 2% salicylic acid gel on skin and investigate their effect on in vitro permeation of salicylic acid through dermatomed porcine ear skin. The studies included evaluation of the gel's rheological properties, gel distribution on skin surface, in vitro permeability, drug distribution in skin, skin extraction recovery, and mass balance...
January 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28061745/large-scale-transcriptome-comparison-of-sunflower-genes-responsive-to-verticillium-dahliae
#13
Shuchun Guo, Yongchun Zuo, Yanfang Zhang, Chengyan Wu, Wenxia Su, Wen Jin, Haifeng Yu, Yulin An, Qianzhong Li
BACKGROUND: Sunflower Verticillium wilt (SVW) is a vascular disease caused by root infection with Verticillium dahliae (V. dahlia). It is a serious threat to the yield and quality of sunflower. However, chemical and agronomic measures for controlling this disease are not effective. The selection of more resistant genotypes is a desirable strategy to reduce contamination. A deeper knowledge of the molecular mechanisms and genetic basis underlying sunflower Verticillium wilt is necessary to accelerate breeding progress...
January 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28058682/mi-1-gene-expression-in-tomato-plants-under-root-knot-nematode-invasion-and-treatment-with-salicylic-acid
#14
V V Lavrova, Zh V Udalova, E M Matveeva, F K Khasanov, S V Zinovieva
The dynamics of expression of two homologous genes Mi-1.1 and Mi-1.2 in the roots of resistant and susceptible tomato plants in non-invasion conditions and during invasion with the root-knot nematode M. incognita was studied. Nematode invasion was accompanied by a significant increase in the expression level of both genes; however, the accumulation of transcripts at the early stages of nematode invasion in the penetration of nematode juveniles to the roots was observed only in plants that contained the Mi-1...
November 2016: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28057894/validating-genome-wide-association-candidates-through-quantitative-variation-in-nodulation
#15
Shaun J Curtin, Peter Tiffin, Joseph Guhlin, Diana I Trujillo, Liana T Burghardt, Paul Atkins, Nicholas J Baltes, Roxanne Denny, Daniel F Voytas, Robert M Stupar, Nevin Dale Young
Genome wide association (GWA) studies offer the opportunity to identify genes that contribute to naturally occurring variation in quantitative traits. However, GWA relies exclusively on statistical association, so functional validation is necessary to make strong claims about gene function. We used a combination of gene-disruption platforms (Tnt1 retro-transposons, hairpin RNA-interference constructs, and CRISPR/Cas9 nucleases) together with randomized, well-replicated experiments to evaluate the function of genes that an earlier GWAS in Medicago truncatula had identified as candidates contributing to variation in the symbiosis between legumes and rhizobia...
January 5, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28057569/a-novel-peroxidase-purified-from-marsdenia-megalantha-latex-inhibits-phytopathogenic-fungi-mediated-by-cell-membrane-permeabilization
#16
Henrique P Oliveira, Rodolpho G G Silva, Jose T A Oliveira, Daniele O B Sousa, Mirella L Pereira, Pedro F N Souza, Arlete A Soares, Valdirene M Gomes, Ana C O Monteiro-Moreira, Frederico B M B Moreno, Ilka M Vasconcelos
An antifungal class III peroxidase was purified from Marsdenia megalantha latex (named Mo-POX) using DEAE-cellulose and gel filtration chromatography on a Superose 12 HR 10/30 column. Mm-POX has an apparent molecular mass of 67.0kDa and a pI of 5.2, shares identity with other peroxidases, and follows Michaelis-Menten kinetics. It has a high affinity for guaiacol and hydrogen peroxide. The pH and temperature optima for Mm-POX were 5.0-7.0 and 60°C, respectively. The catalytic activity of Mm-POX was decreased in the presence of classic peroxidase inhibitors including azide, dithiothreitol, ethylenediamine tetraacetic acid, and sodium metabisulfite and high concentrations of Na(+), Mn(+), and salicylic acid...
January 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28057169/difference-in-the-dissolution-behaviors-of-tablets-containing-polyvinylpolypyrrolidone-pvpp-depending-on-pharmaceutical-formulation-after-storage-under-high-temperature-and-humid-conditions
#17
Yoh Takekuma, Haruka Ishizaka, Masato Sumi, Yuki Sato, Mitsuru Sugawara
PURPOSE: Storage under high temperature and humid conditions has been reported to decrease the dissolution rate for some kinds of tablets containing polyvinylpolypyrrolidone (PVPP) as a disintegrant. The aim of this study was to elucidate the properties of pharmaceutical formulations with PVPP that cause a decrease in the dissolution rate after storage under high temperature and humid conditions by using model tablets with a simple composition. METHODS: Model tablets, which consisted of rosuvastatin calcium or 5 simple structure compounds, salicylic acid, 2-aminodiphenylmethane, 2-aminobiphenyl, 2-(p-tolyl)benzoic acid or 4...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28056792/elucidation-of-the-molecular-responses-of-a-cucumber-segment-substitution-line-carrying-pm5-1-and-its-recurrent-parent-triggered-by-powdery-mildew-by-comparative-transcriptome-profiling
#18
Qiang Xu, Xuewen Xu, Yang Shi, Xiaohua Qi, Xuehao Chen
BACKGROUND: Powdery mildew (PM) is one of the most severe fungal diseases of cucurbits, but the molecular mechanisms underlying PM resistance in cucumber remain elusive. In this study, we developed a PM resistant segment substitution line SSL508-28 that carried a segment on chromosome five representing the Pm5.1 locus from PM resistant donor Jin5-508 using marker-assisted backcrossing of an elite PM susceptible cucumber inbred line D8. RESULTS: Whole-genome resequencing of SSL508-28, Jin5-508 and D8 was performed to identify the exact boundaries of the breakpoints for this introgression because of the low density of available single sequence repeat markers...
January 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28056558/mechanisms-and-strategies-of-plant-defense-against-botrytis-cinerea
#19
Synan AbuQamar, Khaled Moustafa, Lam-Son Phan Tran
Biotic factors affect plant immune responses and plant resistance to pathogen infections. Despite the considerable progress made over the past two decades in manipulating genes, proteins and their levels from diverse sources, no complete genetic tolerance to environmental stresses has been developed so far in any crops. Plant defense response to pathogens, including Botrytis cinerea, is a complex biological process involving various changes at the biochemical, molecular (i.e. transcriptional) and physiological levels...
January 5, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28056110/selection-of-reference-genes-for-qrt-pcr-analysis-of-gene-expression-in-stipa-grandis-during-environmental-stresses
#20
Dongli Wan, Yongqing Wan, Qi Yang, Bo Zou, Weibo Ren, Yong Ding, Zhen Wang, Ruigang Wang, Kai Wang, Xiangyang Hou
Stipa grandis P. Smirn. is a dominant plant species in the typical steppe of the Xilingole Plateau of Inner Mongolia. Selection of suitable reference genes for the quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) is important for gene expression analysis and research into the molecular mechanisms underlying the stress responses of S. grandis. In the present study, 15 candidate reference genes (EF1 beta, ACT, GAPDH, SamDC, CUL4, CAP, SNF2, SKIP1, SKIP5, SKIP11, UBC2, UBC15, UBC17, UCH, and HERC2) were evaluated for their stability as potential reference genes for qRT-PCR under different stresses...
2017: PloS One
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