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https://www.readbyqxmd.com/read/27917533/human-spinal-ejaculation-generator
#1
Clément Chéhensse, Patricia Facchinetti, Stéphane Bahrami, Philippe Andrey, Jean-Marc Soler, Fabrice Chrétien, Jacques Bernabé, Pierre Clément, Pierre Denys, François Giuliano
OBJECTIVE: A spinal ejaculation generator (SEG) has been identified in the rat with lumbar galaninergic interneurons playing a pivotal role (Science 2002;297:1566-1569). The aim was to evidence a SEG in humans. METHODS: Spatial distribution of galaninergic neurons was studied in postmortem spinal cord segments of 6 men and compared with that of 6 women for evidencing sexual dimorphism. Based on the identified segmental distribution of galaninergic neurons, the ability for penile vibratory stimulation (PVS) to elicit ejaculation when the concerned spinal segments were injured was studied in 384 patients with clinically complete spinal cord injury (SCI) and consequent anejaculation...
December 5, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27915066/the-impact-of-hospital-teaching-status-on-timing-of-intervention-inpatient-morbidity-and-mortality-after-surgery-for-vertebral-column-fractures-with-spinal-cord-injury
#2
Rafael De la Garza Ramos, Jonathan Nakhla, Rani Nasser, Ajit Jada, Daniel M Sciubba, Merritt D Kinon, Reza Yassari
OBJECTIVE: To investigate the impact of hospital teaching status on the timing of intervention and inpatient morbidity and mortality after surgery for acute spinal cord injury (SCI). METHODS: Data from the Nationwide Inpatient Sample (2002 - 2011) were reviewed. Patients were included if they had a diagnosis of closed vertebral column fracture with SCI, underwent spine surgery, and were admitted urgently or emergently. Early intervention (the day of or the day after admission), inpatient morbidity and mortality rates were compared between patients admitted to teaching versus nonteaching hospitals...
November 30, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27913838/isolated-transverse-process-fractures-insignificant-injury-or-marker-of-complex-injury-pattern
#3
G Lombardo, P Petrone, K Prabhakaran, C P Marini
INTRODUCTION: This study investigates the incidence of isolated transverse process fractures (ITPFx) amongst vertebral fractures in trauma patients, and specific-associated injury patterns present in patients with ITPFx. MATERIALS AND METHODS: A retrospective, 4-year review of our Level 1 Trauma Center registry was performed. Patients with blunt spinal column fractures were identified. Data collected included patient demographics, Injury Severity Score (ISS), type of imaging obtained, and concomitant injuries, including rib and pelvic fractures, liver, spleen, and kidney injury (SOI)...
December 2, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/27906739/posterior-vertebral-column-resection-with-intraoperative-manual-retraction-for-the-treatment-of-posttubercular-kyphosis-in-upper-thoracic-spine-or-cervicothoracic-junction
#4
Yuqiao Chen, Guohua Lü, Bing Wang, Lei Li, Lei Kuang
STUDY DESIGN: This is a case-series. OBJECTIVE: To evaluate the clinical and radiologic outcomes of posterior vertebral column resection (PVCR) for treatment of posttubercular kyphosis in upper thoracic spine and cervicothoracic junction (CTJ). SUMMARY OF BACKGROUND DATA: Surgical management of severe posttubercular kyphosis in upper thoracic spine or CTJ is challenging. A new technique that combines PVCR and intraoperative manual traction in a single procedure, was developed to maximize the correction rate and minimize the risk of dural buckling and spinal cord injury...
November 30, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27871718/aza%C3%A3-%C3%A3-n-s-disease-a-19th-century-epidemic-of-neurolathyrism-in-spain
#5
REVIEW
S Giménez-Roldán, P S Spencer
The cultivation and consumption of grasspea (Lathyrus sativus) in Spain probably dates back centuries, especially during times of famine when the neurotoxic potential of this legume was expressed in the form of a spastic paraparesis known as neurolathyrism. Little known outside the country, the epidemic of neurolathyrism in the years following the Spanish Civil War (1936-1939) came to affect more than a thousand people. In late 1872, during the Six Years Revolutionary Term, young Alejandro San Martín Satrústegui (1847-1908), then editor of the popular weekly El Siglo Médico, travelled to Azañón, a remote village in the province of Guadalajara, to clarify a so-far unknown disease...
December 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27867025/comparison-of-short-segment-pedicle-fixation-with-versus-without-inclusion-of-the-fracture-level-in-the-treatment-of-mild-thoracolumbar-burst-fractures
#6
Chao Sun, Guoping Guan, Xinhui Liu, Hailong Zhang, Bin Wang
BACKGROUND: A review of the literature showed that posterior short-segment fixation including the fractured vertebra (PSFFV) has better outcomes in the treatment of thoracolumbar burst fractures(TBFs) than patients with short-segment pedicle screw fixation(SSPF) alone. However, its efficacy in mild TBFs with load-sharing scores of 3 and 4 points has not been specifically analyzed. The aim of this study was to compare the clinical, functional and radiologic results of PSFFV with SSPF for mild TBFs and to determine whether the screws in the fractured vetebra were necessary for these patients...
November 17, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27834648/epidural-stimulation-of-rat-spinal-cord-at-lumbosacral-segment-using-a-surface-electrode-a-computer-simulation-study
#7
Qi Xu, Li Kong, Hui Zhou, Jiping He
Clinical research indicates that the epidural spinal cord stimulation (ESCS) at lumbosacral segment has shown potential for promoting locomotor recovery in patients with incomplete spinal cord injury. However, the underlying neural mechanism needs to be determined by animal experiments. In order to refine experimental protocols, we used a finite element simulation to investigate the activation of nerve fibers in a rat spinal cord model. Our model is composed of a volume conductor model from L1 to S2 spinal segments and the McIntyre-Richard-Grill axon model, which is used to investigate the threshold of selected spinal fibers with different diameters at varied locations and predict the neural responses of any target fibers with bipolar electrode configuration...
November 4, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27816708/minimally-invasive-pedicle-screw-fixation-combined-with-percutaneous-vertebroplasty-for-the-treatment-of-thoracolumbar-burst-fracture
#8
Chunbo Li, Jianfeng Pan, Yutong Gu, Jian Dong
INTRODUCTION: To evaluate the feasibility, efficacy and safety of minimally invasive pedicle screw fixation (MIPS) combined with percutaneous vertebroplasty (PVP) using calcium phosphate for the treatment of thoracolumbar burst fracture without neurologic deficits. METHODS: Between September 2011 and April 2013, a total of thirty-seven patients with a mean age of 50.73 years (range 40-63 years), who suffered from thoracic or lumbar burst fracture without neurologic deficits underwent the procedure of MIPS combined with PVP using calcium phosphate...
November 3, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27788683/analysis-of-the-independent-risk-factors-of-neurologic-deficit-after-thoracolumbar-burst-fracture
#9
Peifu Tang, Anhua Long, Tao Shi, Licheng Zhang, Lihai Zhang
BACKGROUND: The objective of this study is to identify the independent risk factors of neurologic deficit after thoracolumbar burst fracture. Traumatic fractures of the thoracolumbar spine are the most common type of spinal column fractures. Many studies have attempted to determine whether neurologic deficit in such fractures is related to spinal canal stenosis or other parameters observed on axial computed tomography. However, this relationship remains controversial. METHODS: A review of the clinical data and axial computed tomography (CT) for 105 patients was performed...
October 24, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27774835/the-contributions-to-the-human-dorsal-column-tracts-from-the-spinal-cord-laminae
#10
Özlem Kirazlı, Bilgehan Solmaz, Safiye Çavdar
The dorsal column tracts (fasciculus gracilis and fasciculus cuneatus) are concerned with discriminative qualities of sensation. There are controversial descriptions related to the relations of dorsal column tracts with the dorsal horn laminae in text-books. The present study aims to define the laminae of the dorsal horn of the spinal cord that contribute fibers to the dorsal column tracts in the cervical, thoracic and lumbar spinal level. Series paraffin spinal cords sections of six formalin-embalmed adult human cadavers were evaluated...
October 24, 2016: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/27766191/vertebral-column-resection-for-kyphoscoliosis-in-a-patient-with-ehlers-danlos-syndrome-an-intraoperative-neurophysiological-monitoring-alert
#11
Faisal R Jahangiri, Sami Al Eissa, Samir Sayegh, Fahad Al Helal, Shomoukh A Al-Sharif, Monerah M Annaim, Sheryar Muhammad, Tanweer Aziz
A 16-year-old male patient with Ehler-Danlos syndrome (EDS) and a back deformity since birth presented with severe kyphoscoliosis. The patient was neurologically intact but had respiratory and cardiac insufficiencies. A two-stage vertebral column resection (VCR) at T9-T10 with multiple level fusion with multimodality intraoperative neurophysiological monitoring (IONM) was planned.  During the first stage, pedicle screws were placed at multiple spinal levels above and below the VCR level. Upper and lower somatosensory evoked potentials (SSEP), transcranial electrical motor evoked potentials (TCeMEP), and electromyography were monitored continuously and showed no significant changes...
August 31, 2016: Curēus
https://www.readbyqxmd.com/read/27713008/ct-based-morphological-analysis-of-spinal-fractures-in-patients-with-diffuse-idiopathic-skeletal-hyperostosis
#12
Eijiro Okada, Takashi Tsuji, Kentaro Shimizu, Masanori Kato, Kentaro Fukuda, Shinjiro Kaneko, Jun Ogawa, Kota Watanabe, Ken Ishii, Masaya Nakamura, Morio Matsumoto
PURPOSE: To clarify correlations between spinal fracture and delayed paralysis in patients with diffuse idiopathic skeletal hyperostosis (DISH) using computed tomography (CT) with multiplanar reformatting (CT-MPR). DISH increases susceptibility to unstable spinal fractures, leading to neurological deterioration. The pathomechanism of the neurological injury is unclear. METHODS: This multicenter retrospective study included 42 DISH patients (32 male; 10 female) treated for 45 spinal fractures during a 5-year period...
October 3, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27701161/bioelectric-medicine-and-devices-for-the-treatment-of-spinal-cord-injury
#13
Tess Torregrosa, Ryan A Koppes
Recovery of motor control is paramount for patients living with paralysis following spinal cord injury (SCI). While a cure or regenerative intervention remains on the horizon for the treatment of SCI, a number of neuroprosthetic devices have been employed to treat and mitigate the symptoms of paralysis associated with injuries to the spinal column and associated comorbidities. The recent success of epidural stimulation to restore voluntary motor function in the lower limbs of a small cohort of patients has breathed new life into the promise of electric-based medicine...
2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/27699211/altered-spatiotemporal-dynamics-of-cortical-activation-to-tactile-stimuli-in-somatosensory-area-3b-and-area-1-of-monkeys-after-spinal-cord-injury
#14
Ruiqi Wu, Langting Su, Pai-Feng Yang, Li Min Chen
Reactivation of deafferented cortex plays a key role in mediating the recovery of lost functions, although the precise mechanism is not fully understood. This study simultaneously characterized the dynamic spatiotemporal features of tactile responses in areas 3b and 1 before and 6-8 weeks after partial dorsal column lesion (DCL), and examined how the reactivation relates to the recovery of simple hand use in squirrel monkeys. A combination of high spatiotemporal resolution functional intrinsic optical imaging, microelectrode mapping, behavioral assessment, and tracer histology methods were used...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27690838/whiplash-associated-disorders-occupant-kinematics-and-neck-morphology
#15
Brian D Stemper, Brian D Corner
Synopsis Despite considerable research effort, the incidence of whiplash injury during automotive collisions has continued to rise. This is due, at least in part, to a limited recognition of biomechanical injury mechanisms and factors influencing injury risk. While automotive safety modifications reduced injury risk in some cases, impact on the overall whiplash incidence was limited. This is likely attributable to significant occupant-related differences that have a profound impact on injury risk. Many of those differences were outlined in research studies, and examples include female sex and the associated sex-based anthropometrical variation that can affect seating orientation; cervical spinal posture; and anatomical attributes, including cervical column slenderness and neck muscle morphometry...
October 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27662382/spine-injuries-in-child-abuse
#16
Julio J Jauregui, Dean C Perfetti, Frank S Cautela, David B Frumberg, Qais Naziri, Carl B Paulino
BACKGROUND: Although rare, spinal injuries associated with abuse can have potentially devastating implications in the pediatric population. We analyzed the association of pediatric spine injury in abused children and determined the anatomic level of the spine affected, while also focusing on patient demographics, length of stay, and total hospital charges compared with spine patients without a diagnosis of abuse. METHODS: A retrospective review of the Kids' Inpatient Database was conducted from 2000 to 2012 to identify pediatric patients (below 18 y) who sustained vertebral column fractures or spinal cord injuries...
September 22, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27645264/longitudinal-enlargement-of-the-lesion-after-spinal-cord-injury-in-the-rat-a-consequence-of-malignant-edema
#17
P Tomko, D Farkaš, D Čížková, I Vanický
STUDY DESIGN: Experimental animal study. OBJECTIVES: Quantitative analysis of secondary changes in lesion size after experimental spinal cord injury (SCI) in the rat, with special emphasis to the formation of dorsal column lesions. SETTING: Slovakia. METHODS: After SCI in the rat, animals survived for different periods ranging from 5 min to 7 days. Their whole spinal cords were cut transversally into 1 mm thick slabs...
September 20, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27638205/autophagy-induction-stabilizes-microtubules-and-promotes-axon-regeneration-after-spinal-cord-injury
#18
Miao He, Yuetong Ding, Chen Chu, Jing Tang, Qi Xiao, Zhen-Ge Luo
Remodeling of cytoskeleton structures, such as microtubule assembly, is believed to be crucial for growth cone initiation and regrowth of injured axons. Autophagy plays important roles in maintaining cellular homoeostasis, and its dysfunction causes neuronal degeneration. The role of autophagy in axon regeneration after injury remains speculative. Here we demonstrate a role of autophagy in regulating microtubule dynamics and axon regeneration. We found that autophagy induction promoted neurite outgrowth, attenuated the inhibitory effects of nonpermissive substrate myelin, and decreased the formation of retraction bulbs following axonal injury in cultured cortical neurons...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27609442/tract-specific-diffusion-tensor-imaging-reveals-laterality-of-neurological-symptoms-in-patients-with-cervical-compression-myelopathy
#19
Satoshi Maki, Masao Koda, Junya Saito, Sho Takahashi, Taigo Inada, Koshiro Kamiya, Mitsutoshi Ota, Yasushi Iijima, Yoshitada Masuda, Koji Matsumoto, Masatoshi Kojima, Kazuhisa Takahashi, Takayuki Obata, Masashi Yamazaki, Takeo Furuya
BACKBROUND: Patients with cervical compression myelopathy (CCM) generally present bilateral neurological symptoms in their extremities. However, a substantial portion of patients with CCM exhibit laterality of neurological symptoms. The aim of this study was to assess the correlation between intrinsic structural damage and laterality of symptoms using spinal cord diffusion tensor imaging (DTI) of the corticospinal tract. METHODS: We enrolled 10 healthy volunteers and 40 patients with CCM in this study...
September 5, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27603096/temporary-percutaneous-pedicle-screw-stabilization-without-fusion-of-adolescent-thoracolumbar-spine-fractures
#20
Shari Cui, Gennadiy A Busel, Aki S Puryear
BACKGROUND: Pediatric spine trauma often results from high-energy mechanisms. Despite differences in healing potential, comorbidities, and length of remaining life, treatment is frequently based on adult criteria; ligamentous injuries are fused and bony injuries are treated accordingly. In this study, we present short-term results of a select group of adolescent patients treated using percutaneous pedicle screw instrumentation without fusion. METHODS: An IRB-approved retrospective review was performed at a level 1 pediatric trauma center for thoracolumbar spine fractures treated by percutaneous pedicle screw instrumentation...
October 2016: Journal of Pediatric Orthopedics
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