Hui-Wen Yang, Dennis Chun-Yu Ho, Heng-Yi Liao, Yi-Wen Liao, Chih-Yuan Fang, Min Yee Ng, Cheng-Chia Yu, Fu-Chen Lin
BACKGROUND/PURPOSE: Oral submucous fibrosis (OSF) is a precancerous lesion in the oral cavity, commonly results from the Areca nut chewing habit. Arecoline, the main component of Areca nut, is known to stimulate the activation of myofibroblasts, which can lead to abnormal collagen I deposition. Meanwhile, Resveratrol is a non-flavonoid phenolic substance that can be naturally obtained from various berries and foods. Given that resveratrol has significant anti-fibrosis traits in other organs, but little is known about its effect on OSF, this study aimed to investigate the therapeutic impact of resveratrol on OSF and its underlying mechanism...
April 2024: Journal of Dental Sciences