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https://www.readbyqxmd.com/read/28823113/dual-mode-endomicroscopy-for-detection-of-epithelial-dysplasia-in-the-mouth-a-descriptive-pilot-study
#1
Nico Bodenschatz, Catherine F Poh, Sylvia Lam, Pierre Lane, Martial Guillaud, Calum E MacAulay
Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering...
August 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28822108/semi-quantitative-metabolic-values-on-fdg-pet-ct-including-extracardiac-sites-of-disease-as-a-predictor-of-treatment-course-in-patients-with-cardiac-sarcoidosis
#2
Mitsutomi Ishiyama, Laurie A Soine, Hubert J Vesselle
BACKGROUND: Cardiac sarcoidosis is associated with major adverse cardiac events including cardiac arrest, for which anti-inflammatory treatment is indicated. Oral corticosteroid is the mainstay among treatment options; however, adverse effects are a major concern with long-term use. It would be beneficial for providers to predict treatment response and prognosis for proper management strategy of sarcoidosis, though it remains challenging. Fluorine (F)-18 fluorodeoxyglucose (FDG)-positron emission tomography(PET)/computed tomography(CT) has an advantage over anatomical imaging in providing semi-quantitative functional parameters such as standard uptake value (SUV), metabolic volume, and total lesion glycolysis (TLG), which are well-established biomarkers in oncology...
August 18, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28818109/metastatic-colorectal-cancer-responsive-to-regorafenib-for-2-years-a-case-report
#3
Kenji Yoshino, Dai Manaka, Ryo Kudo, Shunpei Kanai, Eisei Mitsuoka, Satoshi Kanto, Shinya Hamasu, Sayuri Konishi, Ryuta Nishitai
BACKGROUND: Regorafenib is an oral multikinase inhibitor that has been demonstrated as clinically effective in patients with metastatic colorectal cancer in phase III studies. Although disease control was achieved in 40% of the pretreated patients with metastatic colorectal cancer in the pivotal studies, radiological response has rarely been reported. Severe adverse events associated with regorafenib are known to occur during the first and second courses of treatment. We present a case of a 62-year-old Japanese patient whose metastatic colorectal cancer has been responding to treatment with regorafenib for 2 years...
August 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28817583/dextran-sodium-sulfate-dss-induces-necrotizing-enterocolitis-like-lesions-in-neonatal-mice
#4
Marco Ginzel, Xiaoyan Feng, Joachim F Kuebler, Christian Klemann, Yi Yu, Reinhard von Wasielewski, Joon-Keun Park, Mathias W Hornef, Gertrud Vieten, Benno M Ure, Torsten Kaussen, Jan Hendrik Gosemann, Steffi Mayer, Anne Suttkus, Martin Lacher
BACKGROUND: Necrotizing enterocolitis (NEC) is an inflammatory bowel disease of preterm human newborns with yet unresolved etiology. An established neonatal murine model for NEC employs oral administration of lipopolysaccharides (LPS) combined with hypoxia/hypothermia. In adult mice, feeding dextran sodium sulfate (DSS) represents a well-established model for experimental inflammatory bowel disease. Here we investigated the effect of DSS administration on the neonatal murine intestine in comparison with the established NEC model...
2017: PloS One
https://www.readbyqxmd.com/read/28817168/infection-with-a-novel-derogenid-trematode-in-a-flap-necked-chameleon-chamaeleo-dilepis
#5
Nancy B Collicutt, Nicole I Stacy, Heather Stockdale Walden, April Childress, Jennifer Dill, Marita Anderson, James F X Wellehan
A 2-year-old female Flap-necked chameleon (Chamaeleo dilepis) was presented with a history of anorexia. On physical examination, three 11×4×2 mm, light tan-pink, raised, gelatinous, freely movable, poorly demarcated, raised nodules were identified within the oral cavity. An impression smear contained multiple, light blue to green structures exhibiting an 18×35 μm, elliptical-shaped anterior portion and a single 1×150 μm filament with a tapered end. Initial differential etiologies included trematode ova, flagellate protozoa, fungal sporangia, plant material, and sperm...
August 17, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28816862/unilateral-optic-neuritis-and-central-retinal-vasculitis-due-to-ocular-syphilis
#6
Murtaza S Khan, Dulanji K Kuruppu, Tanav A Popli, Ramana S Moorthy, Devin D Mackay
PURPOSE: Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs of syphilis. METHODS: A case report of a 22-year-old man with progressive unilateral vision loss. RESULTS: With no known previous history of syphilis, genital lesions, or other extraocular manifestations, the patient presented with pain with eye movements and decreased color vision. His vision dramatically worsened after a course of oral steroids...
August 14, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28816197/cytological-changes-in-normal-oral-mucosa-of-individuals-with-tobacco-habits-a-cytomorphometric-study
#7
Pavan Palakurthy, Pavan G Kulkarni, Rateesh K Nandan, T Madhusudan Rao, D Shyam P Reddy, Keerthi Muddana
INTRODUCTION: Oral cancer is one of the six most common cancers in the world, and globally more than 50% of head and neck cancers occur in Asia, remarkably in India. Overall, 200,000 cases of head and neck cancers occur each year in India, among which 80,000 are oral cancers. Epidemiological and clinical studies suggest a causative role of tobacco use in the evolution of oral potentially malignant and malignant disorders. AIMS AND OBJECTIVES: The aim of the study is to evaluate independently and compare the cytological effects of smoking, tobacco chewing, and smoking in conjunction with tobacco chewing on oral mucosa by cytomorphometric analysis...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28816192/tobacco-abuse-and-associated-oral-lesions-among-interstate-migrant-construction-workers
#8
Anzil Ks Ali, Arshad Mohammed, Archana A Thomas, Shann Paul, M Shahul, K Kasim
AIM: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India. MATERIALS AND METHODS: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28816119/clinical-presentation-and-management-of-dyskinetic-cerebral-palsy
#9
REVIEW
Elegast Monbaliu, Kate Himmelmann, Jean-Pierre Lin, Els Ortibus, Laura Bonouvrié, Hilde Feys, R Jeroen Vermeulen, Bernard Dan
Cerebral palsy is the most frequent cause of severe physical disability in childhood. Dyskinetic cerebral palsy (DCP) is the second most common type of cerebral palsy after spastic forms. DCP is typically caused by non-progressive lesions to the basal ganglia or thalamus, or both, and is characterised by abnormal postures or movements associated with impaired tone regulation or movement coordination. In DCP, two major movement disorders, dystonia and choreoathetosis, are present together most of the time. Dystonia is often more pronounced and severe than choreoathetosis, with a major effect on daily activity, quality of life, and societal participation...
September 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28814981/cpg-location-and-methylation-level-are-crucial-factors-for-the-early-detection-of-oral-squamous-cell-carcinoma-in-brushing-samples-using-bisulfite-sequencing-of-a-13-gene-panel
#10
Luca Morandi, Davide Gissi, Achille Tarsitano, Sofia Asioli, Andrea Gabusi, Claudio Marchetti, Lucio Montebugnoli, Maria Pia Foschini
BACKGROUND: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. The purpose of this study was to evaluate the diagnostic value of methylation level in a set of 18 genes by bisulfite next-generation sequencing...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28814370/unusual-case-of-graphite-tattoo-in-a-pediatric-patient-clinical-presentation-and-differential-diagnosis
#11
Paulo de Camargo Moraes, Victor Angelo Martins Montalli, José Luiz Cintra Junqueira, Francine Kühl Panzarella, Luciana Butini Oliveira
Graphite tattoo, a rare finding in children, is characterized by a localized blue-grey macule of variable sizes and shapes. Intraoral graphite implantation may cause this pigmentation through accidental injury with a graphite pencil. The purpose of this paper is to report an unusual case of graphite tattoo involving the anterior palate region in a seven-year-old girl. A diagnosis was made based on clinical and radiographic examinations and histopathology features. This report also highlights the importance of differential diagnosis and management of oral benign and malignant pigmented lesions in children...
May 15, 2017: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28814316/evaluation-of-sarolaner-and-spinosad-oral-treatments-to-eliminate-fleas-reduce-dermatologic-lesions-and-minimize-pruritus-in-naturally-infested-dogs-in-west-central-florida-usa
#12
Michael W Dryden, Michael S Canfield, Emily Niedfeldt, Amanda Kinnon, Kimberly Kalosy, Amber Smith, Kaitlin M Foley, Vicki Smith, Todd S Bress, Nicole Smith, Mike Endrizzi, Joyce Login
BACKGROUND: An in-home investigation of naturally flea infested dogs was conducted in West Central Florida, USA to evaluate and compare the effectiveness of two different oral flea adulticides to control flea infestations, minimize dermatologic lesions and reduce pruritus over an 8-week period. METHODS: Twenty-nine dogs living in 19 homes and another 26 dogs residing in 16 different homes were orally administered either a sarolaner or spinosad chewable, respectively on day 0 and once between days 28-30...
August 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28814183/diagnoses-and-treatment-of-dental-disorders-in-a-research-colony-of-macaca-fascicularis-a-case-series
#13
Philippe Roux, Muriel Brecheisen, Rafael de Carvalho, Alessandra Bergadano
During daily routine oral examinations in a research colony of nonhuman primates (NHPs, Macaca fascicularis), a variety of oral-dental lesions were identified. A dental care program was established based on these findings. Based on the presence of dental clinical signs and their severity, 31 animals were triaged to be examined and treated by a veterinarian. Clinical examination consisted of visual inspection using a periodontal probe/explorer and full or partial mouth dental radiographs. Treatment was performed during the same procedure...
September 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28814181/full-mouth-intraoral-radiographic-survey-in-rabbits
#14
Adriana Regalado, Loïc Legendre
Dental pathologies are highly prevalent in pet rabbit populations, making oral radiography an essential tool in the evaluation of lagomorph dentitions. The unique anatomy of the rabbit's mouth limits the examination of the conscious animal to the rostral portion of it's mouth. In addition, the oral examination of an aradicular hypsodont tooth is restricted to the short coronal fraction of its crown. Erstwhile images obtained by the extraoral technique were once considered the most practical and informative tool in rabbit dentistry; however, limited visualization of the key structures of individual teeth became the major drawback of this technique...
September 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28813771/hepatic-adenoma-a-case-report
#15
Hasan H Turaihi, Thavam C Thambi-Pillai
Although liver lesions in the young population are relatively rare, clinicians can benefit from being familiar with a subset of common benign liver lesions which include hepatic adenoma, hepatic hemangioma, and focal nodular hyperplasia. This a case report of a 25-year-old Jehovah's Witness female on chronic oral contraception for polycystic ovarian syndrome who presented with progressive right upper quadrant abdominal pain. Ultrasound and MRI findings were consistent with hepatic adenoma. A description of her clinical work up followed by a brief description of the surgical intervention is discussed...
March 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28813105/a-scientific-survey-on-1550-cases-of-oral-lesions-diagnosed-in-a-brazilian-referral-center
#16
Artur C Vasconcelos, Carlos Aburad, Igor F P Lima, Sheila M M Santos, Silas Antonio J DE Freitas, Ademir Franco, Sigmar M Rode, Luiz R Paranhos
The present study aimed to perform an epidemiological survey on the prevalence rate of oral lesions diagnosed in a referral center in Brazil and to establish association between the lesions and the age and gender of the affected patients. This analytical observational study analyzed 3521 medical records of anatomopathological exams of the Pathological Anatomy and Cytopathology Laboratory of the Cancer Hospital of the state of Mato Grosso (Brazil), from December 2011 to September 2015. A total of 1550 relevant medical records was detected...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28811215/molecular-mechanisms-underlying-protection-against-h9n2-influenza-virus-challenge-in-mice-by-recombinant-lactobacillus-plantarum-with-surface-displayed-ha2-ltb
#17
Yanlong Jiang, Guilian Yang, Qi Wang, Zhannan Wang, Wentao Yang, Wei Gu, Chunwei Shi, Jianzhong Wang, Haibin Huang, Chunfeng Wang
It has been considered that the Avian influenza virus (AIV) causes severe threats to poultry industry. In this study, we constructed a series of recombinant Lactobacillus plantarum (L. plantarum) with surface displayed hemagglutinin subunit 2 (HA2) alone or together with heat-labile toxin B subunit (LTB) from enterotoxigenic Escherichia coli. Balb/c mice were used as model to evaluate the protective effects of recombinant L. plantarum strains against H9N2 subtype challenge. The results showed that the presence of LTB significantly increased the percentages of CD3(+)CD4(+)IL-4(+), CD3(+)CD4(+)IFN-γ(+) and CD3(+)CD4(+)IL-17(+) T cells, as well as CD3(+)CD8(+)IFN-γ(+) T cells in spleen and MLNs determined by Fluorescence-Activated Cell Sorting assay...
August 12, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28810997/cutaneous-leishmaniasis-in-a-saudi-arabian-soldier-stationed-in-the-united-states
#18
Kelly Laurent, Jason Susong, Eric Fillman, Simon Ritchie
BACKGROUND: Leishmaniasis is a common parasitic disease seen in many parts of the world, especially in areas where current U.S. and international forces are deployed. Approximately 350 million people are thought to be at risk of cutaneous leishmaniasis (CL) with an annual incidence of 1.5 million cases. Over 90% of cutaneous infections with Leishmania occur in the Middle East, Brazil, and Peru. Outbreaks of CL may occur in military personnel deployed to endemic areas. Since the incubation period for symptomatic CL ranges from weeks to months, symptoms may not appear until well after returning to the United States...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810906/atypical-presentation-of-anti-n-methyl-d-aspartate-receptor-encephalitis-two-case-reports
#19
Maria Cristina Maggio, Greta Mastrangelo, Aldo Skabar, Alessandro Ventura, Marco Carrozzi, Giuseppe Santangelo, Francesca Vanadia, Giovanni Corsello, Rolando Cimaz
BACKGROUND: Anti-N-methyl-D-aspartate receptor encephalitis is a rare autoimmune disease characterized by severe neurological and psychiatric symptoms and a difficult diagnosis. The disease is often secondary to a neoplastic lesion, seldom diagnosed years later. Psychiatric symptoms are prevalent in adults; neurologic symptoms are more evident in children, who typically present primarily with neurological symptoms. To the best of our knowledge, the association with juvenile idiopathic arthritis has not been described...
August 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28809381/serum-levels-of-rankl-and-opg-and-the-rankl-opg-ratio-in-bisphosphonate-related-osteonecrosis-of-the-jaw-are-they-useful-biomarkers-for-the-advanced-stages-of-osteonecrosis
#20
L Bagan, Y Jiménez, M Leopoldo, A Rubert, J Bagan
BACKGROUND: We determined whether serum levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), Osteoprotegerin (OPG), and the RANKL/OPG ratio could be useful biomarkers for the severity of oral lesions in bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: A case-control study in which Group 1 consisted of 41 patients with BRONJ due to intravenous bisphosphonates, and Group 2 consisted of 44 healthy control cases. The plasma levels of RANKL and OPG were analyzed by an ELISA assay...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
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