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https://www.readbyqxmd.com/read/29475177/impact-of-pre-procedural-dual-antiplatelet-therapy-on-periprocedural-myocardial-infarction-in-patients-undergoing-percutaneous-coronary-interventions-with-adjunctive-tirofiban
#1
Monica Verdoia, Patrizia Pergolini, Lucia Barbieri, Roberta Rolla, Matteo Nardin, Federica Negro, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Recent trials have failed to demonstrate any clinical benefit from pre-treatment with dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary interventions, (PCI), even in the setting of acute coronary syndrome. However, suboptimal platelet inhibition during (PCI) has been shown to enhance the risk of acute ischemic complications, such as stent thrombosis and periprocedural myocardial infarction (PMI), thus raising the attention on the potential advantages of adjunctive glycoprotein IIbIIIa inhibitors to obviate to the delayed onset of action of oral antiplatelet drugs...
February 15, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29475082/a-rare-case-of-oral-metastasis-of-colon-adenocarcinoma
#2
I Romanet, R Lan, U Ordioni, A F Albertini, F Campana
INTRODUCTION: Metastatic carcinoma of the colon is frequently encountered. In the literature, metastasis of malignant tumors in the buccal cavity are rare. They represent less than 1% of oral malignant lesions. OBSERVATION: We present a case of oral metastasis of colon adenocarcinoma in the mandible of a 62-year-old patient. The physical examination revealed a swelling in the mandibular symphysis associated with dental displacement. The panoramic X-ray showed significant bone lysis of the symphysis...
February 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29475068/acute-subchronic-oral-toxicity-toxicokinetics-and-genotoxicity-studies-of-dfc-2-an-antitubercular-drug-candidate
#3
Hoonhee Seo, Hafij Al Mahmud, Sukyung Kim, Md Imtiazul Islam, Kee-In Lee, Young Sig Gil, Ho-Yeon Song
The infectious disease tuberculosis remains a serious global health issue and is responsible for nearly 1.8 million deaths every year. In our previous study, DFC-2 was confirmed to show anti-tubercular activity against drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis. To support the safety-in-use of DFC-2 as an anti-tubercular drug, DFC-2 was tested via single- and 28-day repeated-dose oral toxicity study and mutagenicity assays. In the oral toxicity study, a single oral dose of DFC-2 at 2000 mg/kg did not produce deaths or abnormal lesions in the internal organs of rats...
February 20, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29473040/direct-immunofluorescence-using-non-lesional-buccal-mucosa-in-mucous-membrane-pemphigoid
#4
Mayumi Kamaguchi, Hiroaki Iwata, Inkin Ujiie, Hideyuki Ujiie, Jun Sato, Yoshimasa Kitagawa, Hiroshi Shimizu
Mucous membrane pemphigoid (MMP) is a rare organ-specific autoimmune subepithelial blistering disease with predominantly mucosal erosions, most frequently affecting the gingiva. Erosions in the oral cavity usually result in markedly decreased quality of life. The major autoantigens are BP180 and laminin332, which are components of basement membrane proteins in the skin and mucosa. Diagnosis is usually difficult due to histological destruction of the tissue and low autoantibody titers. In this study, we evaluated the diagnostic value of direct immunofluorescence (DIF) using non-lesional buccal mucosa in seven cases of MMP...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29472048/oral-lichen-planus-differential-diagnoses-serum-autoantibodies-hematinic-deficiencies-and-management
#5
REVIEW
Chun-Pin Chiang, Julia Yu-Fong Chang, Yi-Ping Wang, Yu-Hsueh Wu, Shin-Yu Lu, Andy Sun
Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. OLP more commonly affects buccal mucosa, tongue, and gingiva. It always has a bilateral and symmetric distribution of the oral lesions...
February 19, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29469793/lesiones-subcut%C3%A3-neas-dolorosas-en-paciente-con-melanoma-metast%C3%A3-sico-un-caso-de-paniculitis-linfoc%C3%A3-tica-asociado-a-vemurafenib
#6
Felipe Benavente-Villegas, Francisco Ferrando-Roca, Raquel Dolz-Gaitón, María Royo-Peiró
Vemurafenib ha probado ser una herramienta útil en el tratamiento de melanoma metastásico con mutación BRAF-V600E. Los efectos adversos incluyen artralgias, fatiga y toxicidad cutánea, siendo infrecuente la paniculitis. Presentamos el caso de una paciente de 43 años con melanoma metastásico que desarrolla lesiones subcutáneas dolorosas en miembros inferiores y superiores, asociadas a clínica sistémica después de 2 semanas de inicio de tratamiento con Vemurafenib + Cobimetinib. La histología demostró paniculitis linfocitaria septal y lobulillar...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469780/non-dermatomal-varicella-zoster-skin-infection-disseminated-cutaneous-herpes-zoster-without-dermatome-in-an-immunosuppressed-woman
#7
Lindsay P Osborn, Philip R Cohen
Disseminated herpes zoster is defined as the presence of more than 20 lesions outside the dermatome. This unusual presentation is more common in immunosuppressed patients. Complications such as hepatitis, encephalitis, and pneumonitis are more likely in individuals with disseminated varicella zoster virus infection.A 63-year-old woman being treated for breast cancer developed multiple pustules and vesicles days after starting doxorubicin and cyclophosphamide chemotherapy. Ten individual lesions appeared on her chest, abdomen, back, and leg...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469755/atypical-presentations-of-pityriasis-rosea-a-reply
#8
Giulia Ciccarese, Francesco Drago
Pityriasis rosea (PR) may have atypical presentations as regards morphology and distribution of the lesions. Recently, several forms of PR considered atypical for the course of the disease have been described. Differently from the typical PR that resolves within 2-12 weeks, relapsing and persistent PR forms (lasting longer than 12 weeks) have been described in adults and children. Lesions of the oral mucosa in PR may be more common than as reported in the literature. Formerly, the occurrence of oral lesions in PR has been considered more frequent in dark-skinned patients compared to light-skinned patients...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469744/folliculin-mutation-negative-trichodiscomas-in-a-patient-with-multiple-endocine-neoplasia-type-i-syndrome
#9
Jennifer E Yeh, Steven R Tahan, Susan Burgin
Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma that involves the oral mucosal. The manifestation of lesions within the oral cavity generally correlates with a poor prognosis. Management of MF includes skin directed therapies and localized radiation treatment, with systemic biologic therapies and chemotherapy used for more advanced stages. The clinical and histologic features of MF in a patient with oral disease are reviewed.
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469739/cowden-syndrome-clinical-case-and-a-brief-review
#10
Sofia Lopes, Julia Vide, Elisabete Moreira, Filomena Azevedo
Cowden syndrome is a rare genodermatosis of autosomal dominant inheritance characterized by multiple hamartomas in several organs and an increased risk of malignancies. We present the case of a 53-year-old man with a history of benign and malignant thyroid disease, intestinal polyposis, and Chiari malformation. He had several trichilemmomas, papillomatosis of the oral cavity, macular pigmentation of the glans penis, among other clinical features suggestive of Cowden syndrome. Given the suspicion, genetic study was conducted and PTEN mutation was identified...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469724/oral-lesions-as-an-important-marker-for-hiv-progression
#11
Paulo Henrique Braz-Silva, Juliana Lucena Schussel, Karen López Ortega, Marina Gallottini
BACKGROUND: Oral hairy leukoplakia (OHL) is a benign lesion caused by Epstein-Barr virus (EBV) replication in the oral epithelium affecting the borders of the tongue. It is strongly associated with immunosuppression, especially in HIV+ adults but is uncommon in pediatric population. The aim of the study is to show the importance of the correct diagnosis of OHL and its influence on HIV treatment.We report two cases of HIV+ adolescent patients that presented with leukoplakic lesions on the border of the tongue, suggestive of OHL...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469702/infantile-bullous-pemphigoid-with-string-of-pearls-sign
#12
Inês Raposo, Susana Machado, Rita Sampaio, Manuela Selores
Bullous pemphigoid (BP) is an immune mediated bullous disease that is manifested by urticarial plaques with superimposed subepidermal blisters and significant pruritus. It is generally found in the elderly, but is rare in the pediatric population. A 5-month-old girl previously diagnosed with hand-foot-mouth disease was examined in our dermatology department owing to vesicles and bullae, initially located to the hands and feet, which progressed with new lesions. Tense vesicles and bullae distributed in an annular string of pearls pattern on the abdomen and facial and cervical regions were noted...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469597/treatment-of-multiple-eccrine-hidrocystoma-with-oral-isotretinoin-following-erbium-yttrium-aluminum-garnet-laser
#13
Serkan Demirkan
Eccrine hidrocystomes (EH) are benign cystic tumors of dermal eccrine ducts. There is still no gold standard treatment option for EH because of the large number of lesions, the risk of cicatrization and the different treatment options offered. We offer combined oral isotretinoin and following erbium-yttrium aluminum garnet laser treatment as an alternative treatment option in difficult patients with EH.
February 22, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29468684/re-evaluation-of-the-regulation-of-omeprazole-in-racehorses-an-evidence-based-approach
#14
M Viljanto, L Hillyer, P Hincks, C Pearce, S W Paine
Medication control and doping control have been established in horse racing to ensure the integrity of the sport and the welfare of the horses. This ensures that horses do not compete under the influence of any drugs, including omeprazole, a therapeutic medication used to treat equine gastric ulcer syndrome. In this study, pharmacokinetic data were produced in equine plasma and urine following an oral administration of 4 mg/kg of generic buffered formulation of omeprazole to six Thoroughbred horses in five daily doses to determine an appropriate screening limit and detection time in equine plasma and to assess whether the current detection time of 72 hr in equine urine would be applicable when an alternative omeprazole product is administered...
February 22, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29468228/two-cases-of-differentiation-syndrome-with-ocular-manifestations-in-patients-with-acute-promyelocytic-leukaemia-treated-with-all-trans-retinoic-acid-and-arsenic-trioxide
#15
A R Newman, B Leung, A Richards, T G Campbell, J Wellwood, F R Imrie
Purpose: To describe two cases of differentiation syndrome presenting with ocular manifestations including bilateral chorioretinopathy in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and arsenic trioxide differentiation therapy. Observations: This observational case series identifies two patients at a single tertiary institution diagnosed with differentiation syndrome with associated ophthalmic involvement. Both patients reported bilateral reduction in visual acuity at days fourteen and ten respectively following initiation of differentiation therapy in addition to developing other systemic manifestations of differentiation syndrome...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29468223/a-case-of-hypertrophic-herpes-simplex-virus-affecting-the-eyelid-and-cornea-masquerading-as-igg4-related-disease
#16
Prachi Dua, Roman Shinder, Derek B Laskar, Douglas R Lazzaro, Allison E Rizzuti
Purpose: To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. Observations: A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upper and lower eyelids, and severe ocular inflammation with symblepharon...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29465698/enhanced-molecular-typing-of-treponema-pallidum-subsp-pallidum-strains-from-four-italian-hospitals-shows-geographical-differences-in-strain-type-heterogeneity-widespread-resistance-to-macrolides-and-lack-of-mutations-associated-with-doxycycline-resistance
#17
Lorenzo Giacani, Giulia Ciccarese, Christian Puga-Salazar, Ivano Dal Conte, Laura Colli, Marco Cusini, Stefano Ramoni, Sergio Delmonte, Antonietta D'Antuono, Valeria Gaspari, Francesco Drago
BACKGROUND: Although syphilis rates have been relatively high in Italy for over 15 years, no data on the molecular types of Treponema pallidum subsp. pallidum (T. pallidum) circulating in this country are yet available. Likewise, no data exist on how widespread is resistance to macrolide or tetracycline antibiotics in these strains. Such data would however promote comprehensive studies on the molecular epidemiology of syphilis infections in Italy and inform future interventions aiming at syphilis control in this and other European countries...
October 10, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465697/high-baseline-anal-hpv-and-abnormal-anal-cytology-in-a-phase-3-trial-of-the-quadrivalent-hpv-vaccine-in-hiv-infected-individuals-over-26-years-old-actg-5298
#18
Ross D Cranston, Michelle S Cespedes, Pawel Paczuski, Ming Yang, Robert W Coombs, Joan Dragavon, Alfred Saah, Catherine Godfrey, Jennifer Y Webster-Cyriaque, Elizabeth Y Chiao, Barbara Bastow, Timothy Wilkin
BACKGROUND: The quadrivalent human papillomavirus (HPV) vaccine (qHPV; types 6, 11, 16, 18) is indicated for men and women 9-26 years to prevent HPV associated anogenital high grade squamous intraepithelial lesions (HSIL) and cancer. ACTG 5298 was a randomized placebo controlled Phase 3 study in HIV-infected men who have sex with men (MSM), and women of qHPV to prevent persistent anal HPV infection. Baseline data is presented here. METHODS: HIV-infected MSM, and women ≥ 27 years without previous anogenital or oral cancer were enrolled...
October 13, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465494/68ga-psma-pet-ct-revealing-unusual-inguinal-canal-and-distant-nodal-metastasis-in-a-case-of-castration-resistant-prostate-cancer
#19
Shelvin Kumar Vadi, Rajender Kumar, Bhagwant Rai Mittal, Harmandeep Singh, Shrawan Kumar Singh
Gallium-prostate-specific membrane antigen (Ga-PSMA) is well established in the imaging of prostate cancer (PC). Here, we report a case of castration-resistant PC who underwent Ga-PSMA PET/CT for recurrence evaluation, which revealed metastatic lesions in distant lymph nodes and additionally an unusual metastatic deposit in the inguinal canal. The second Ga-PSMA PET/CT done after oral hormonal therapy yielded a favorable response. This pattern of distant metastatic spread is a rare presentation of PC, and PSMA PET/CT revealed the unusual metastasis in the inguinal canal with a timely therapy culminating in favorable disease response...
February 21, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29464980/evaluation-the-efficacy-of-trichloroacetic-acid-tca-33-in-treatment-of-oral-retinoid-induced-cheilitis-compared-with-placebo-vaseline-a-randomized-pilot-study
#20
Parvin Mansouri, Zahra Azizian, Zeinab Najafi, Somaye Hejazi, Shima Younespour
BACKGROUND: Oral Isotretinoin (13-cis-retinoic acid)is a gold standardtreatment for severe forms of acne with cheilitis as a most frequent complication.we designed this novel study to investigate the therapeutic effect of Trichloroacetic Acid(TCA) 33% as compared with placebo to treat cheilitis. METHODS: In this pilot study, 90 acne vulgaris patients between 18 to 50 years, who refered dermatologic clinic with cheilitis, were assigned to either case (TCA) or control (Vaseline) group using permuted-block randomization from 2013 to 2015,with data analysis in 2016...
February 21, 2018: Journal of Dermatological Treatment
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