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Vaginal microbiome

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https://www.readbyqxmd.com/read/29791775/vaginal-microbiome-in-early-pregnancy-and-subsequent-risk-of-spontaneous-preterm-birth-a-case-control-study
#1
Negar Tabatabaei, A Murat Eren, Luis B Barreiro, Vania Yotova, Anne Dumaine, Catherine Allard, William D Fraser
OBJECTIVES: To explore differences in vaginal microbiome between preterm and term deliveries. DESIGN: Nested case-control study in 3D cohort. SETTING: Quebec, Canada. SAMPLE: Ninety-four cases with spontaneous preterm birth (17 early (<34 wk) and 77 late (34-36 wk) preterm birth) and 356 controls with term delivery (≥37 wk). METHODS: To assess vaginal microbiome by sequencing the V4 region of 16S ribosomal-RNA (rRNA) gene in swabs self-collected early pregnancy...
May 23, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29791773/vaginal-microbiome-studies-in-pregnancy-must-also-analyse-host-factors
#2
S S Witkin
It seems logical that the composition of the vaginal microbiota would be a significant variable influencing pregnancy outcome. Bacteria that are not part of the normal microbiota can trigger induction of myometrial contractions and premature delivery. Components of the endogenous microbiome may also be capable, under conditions still ill-defined, of interfering with pregnancy progression. This article is protected by copyright. All rights reserved.
May 23, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29788027/the-neonatal-microbiome-and-its-partial-role-in-mediating-the-association-between-birth-by-cesarean-section-and-adverse-pediatric-outcomes
#3
Diana Montoya-Williams, Dominick J Lemas, Lisa Spiryda, Keval Patel, O'neshia Olivia Carney, Josef Neu, Tiffany L Carson
BACKGROUND: Cesarean sections (CS) are among the most commonly performed surgical procedures in the world. Epidemiologic data has associated delivery by CS with an increased risk of certain adverse health outcomes in children, such as asthma and obesity. OBJECTIVE: To explore what is known about the effect of mode of delivery on the development of the infant microbiome and discuss the potentially mediating role of CS-related microbial dysbiosis in the development of adverse pediatric health outcomes...
May 22, 2018: Neonatology
https://www.readbyqxmd.com/read/29780807/a-critical-review-of-the-bacterial-baptism-hypothesis-and-the-impact-of-cesarean-delivery-on-the-infant-microbiome
#4
REVIEW
Lisa F Stinson, Matthew S Payne, Jeffrey A Keelan
Numerous studies suggest that infants delivered by cesarean section are at a greater risk of non-communicable diseases than their vaginal counterparts. In particular, epidemiological studies have linked Cesarean delivery with increased rates of asthma, allergies, autoimmune disorders, and obesity. Mode of delivery has also been associated with differences in the infant microbiome. It has been suggested that these differences are attributable to the "bacterial baptism" of vaginal birth, which is bypassed in cesarean deliveries, and that the abnormal establishment of the early-life microbiome is the mediator of later-life adverse outcomes observed in cesarean delivered infants...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29776928/enrichment-of-clinically-relevant-organisms-in-spontaneous-preterm-delivered-placenta-and-reagent-contamination-across-all-clinical-groups-in-a-large-uk-pregnancy-cohort
#5
Lydia J Leon, Ronan Doyle, Ernest Diez-Benavente, Taane G Clark, Nigel Klein, Philip Stanier, Gudrun E Moore
In this study differences in the placental microbiota of term and preterm deliveries from a large UK pregnancy cohort were studied using 16S targeted amplicon sequencing. The impact of contamination from DNA extraction, PCR reagents, as well as those from delivery itself were also examined. A total of 400 placental samples from 256 singleton pregnancies were analysed and differences investigated between spontaneous preterm, non-spontaneous preterm, and term delivered placenta. DNA from recently delivered placenta was extracted, and screening for bacterial DNA was carried out using targeted sequencing of the 16S rRNA gene on the Illumina MiSeq platform...
May 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29772525/vaginal-microbiota-dysmicrobism-and-role-of-biofilm-forming-bacteria
#6
Giuseppina Campisciano, Nunzia Zanotta, Vincenzo Petix, Lucia Corich, Francesco De Seta, Manola Comar
Bacterial vaginosis involves the presence of a polymicrobial biofilm on the vaginal epithelium, guaranteeing immune escape and spread of antibiotic resistance. To spot known biofilm-forming bacteria, we profiled the vaginal microbiome of sixty-four symptomatic women suffering from a different grade of vaginal disorders and sixty asymptomatic healthy women. Specific microbial profiles distinguished symptomatic from asymptomatic women and characterized the grade of dysmicrobism within the symptomatic group. Lactobacillus crispatus and iners predominated on the healthy vaginal mucosa, while Lactobacillus gasseri predominated in the intermediate dysmicrobism...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29761040/viromes-of-one-year-old-infants-reveal-the-impact-of-birth-mode-on-microbiome-diversity
#7
Angela McCann, Feargal J Ryan, Stephen R Stockdale, Marion Dalmasso, Tony Blake, C Anthony Ryan, Catherine Stanton, Susan Mills, Paul R Ross, Colin Hill
Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We performed a metagenomic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity...
2018: PeerJ
https://www.readbyqxmd.com/read/29760169/dysbiosis-of-maternal-and-neonatal-microbiota-associated-with-gestational-diabetes-mellitus
#8
Jinfeng Wang, Jiayong Zheng, Wenyu Shi, Nan Du, Xiaomin Xu, Yanming Zhang, Peifeng Ji, Fengyi Zhang, Zhen Jia, Yeping Wang, Zhi Zheng, Hongping Zhang, Fangqing Zhao
OBJECTIVE: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates. DESIGN: Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected...
May 14, 2018: Gut
https://www.readbyqxmd.com/read/29757476/limitations-of-treating-pregnant-women-based-solely-on-vaginal-ph
#9
S S Witkin
It has been widely assumed that a vaginal pH >5.0 in pregnant women indicates the presence of an abnormal vaginal microbiome that increases risk of a preterm delivery. Bellard et al. (BJOG 2018;xx), hypothesized that a single 5 day treatment with Clindamycin would restore the vaginal pH to < 4.5 by selectively eliminating the "harmful" bacteria, and, consequently, reduce the rate of preterm birth in treated women. This article is protected by copyright. All rights reserved.
May 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29753695/the-microbiome-in-preterm-birth
#10
REVIEW
Derrick M Chu, Maxim Seferovic, Ryan M Pace, Kjersti M Aagaard
The microbiome is thought to play a role in the maintenance of a healthy pregnancy and thus may either contribute to or protect from preterm birth. Study of the human microbiome has been aided by metagenomic sequencing approaches, providing greater insight into the commensal bacteria that coexist in and on our bodies. The vaginal microbiome has been the most widely studied, though there have been recent efforts to explore the gut, cervical-vaginal, placental and oral microbiomes in the further search of etiologies of preterm birth...
April 9, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29744039/has-knowledge-of-the-vaginal-microbiome-altered-approaches-to-health-and-disease
#11
REVIEW
Gregor Reid
Sixteen years ago, when we published the first molecular characterization of the vaginal microbiota, little did we know the vast numbers of species that would be detected in this niche. As exciting as these discoveries have been, what have they and more recent advances contributed to how vaginal health and disease are managed? This review provides a brief discussion of the potential, but so far limited, applications that have arisen from microbiome research. Calls for innovation have been made before but to little avail...
2018: F1000Research
https://www.readbyqxmd.com/read/29739953/diversity-time-period-and-diversity-time-area-relationships-exemplified-by-the-human-microbiome
#12
Zhanshan Sam Ma
We extend the ecological laws of species-time relationship (STR) and species-time-area relationship (STAR) to general diversity time-period relationship (DTR) and diversity-time-area relationship (DTAR), and test the extensions with the human vaginal microbiome datasets by building 1460 DTR/DTAR models. Our extensions were inspired by the observation that Hill numbers, well regarded as the most appropriate measure of alpha-diversity and also particularly suitable for multiplicative beta-diversity partitioning, are actually in the units of effective species, and therefore, should be able to substitute for species in the STR and STAR...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738749/the-vaginal-eukaryotic-dna-virome-and-preterm-birth
#13
Kristine M Wylie, Todd N Wylie, Alison G Cahill, George A Macones, Methodius G Tuuli, Molly J Stout
BACKGROUND: Despite decades of attempts to link infectious agents to preterm birth, an exact causative microbe or community of microbes remains elusive. Culture-independent sequencing of vaginal bacterial communities demonstrates community characteristics are associated with preterm birth, although none are specific enough to apply clinically. Viruses are important components of the vaginal microbiome and have dynamic relationships with vaginal bacterial communities. We hypothesized that vaginal eukaryotic DNA viral communities (the "vaginal virome") either alone or in the context of bacterial communities are associated with preterm birth...
May 5, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29737047/generalized-hotelling-s-test-for-paired-compositional-data-with-application-to-human-microbiome-studies
#14
Ni Zhao, Xiang Zhan, Katherine A Guthrie, Caroline M Mitchell, Joseph Larson
The human microbiome is a dynamic system that changes due to diseases, medication, change in diet, etc. The paired design is a common approach to evaluate the microbial changes while controlling for the inherent differences between people. For example, microbiome data may be collected from the same individuals before and after a treatment. Two challenges exist in analyzing this type of data. First, microbiome data are compositional such that the reads for all taxa in each sample are constrained to sum to a constant...
May 7, 2018: Genetic Epidemiology
https://www.readbyqxmd.com/read/29724017/low-maternal-microbiota-sharing-across-gut-breast-milk-and-vagina-as-revealed-by-16s-rrna-gene-and-reduced-metagenomic-sequencing
#15
Ekaterina Avershina, Inga Leena Angell, Melanie Simpson, Ola Storrø, Torbjørn Øien, Roar Johnsen, Knut Rudi
The maternal microbiota plays an important role in infant gut colonization. In this work we have investigated which bacterial species are shared across the breast milk, vaginal and stool microbiotas of 109 women shortly before and after giving birth using 16S rRNA gene sequencing and a novel reduced metagenomic sequencing (RMS) approach in a subgroup of 16 women. All the species predicted by the 16S rRNA gene sequencing were also detected by RMS analysis and there was good correspondence between their relative abundances estimated by both approaches...
May 1, 2018: Genes
https://www.readbyqxmd.com/read/29718358/identification-of-key-bacteria-involved-in-the-induction-of-incident-bacterial-vaginosis-a-prospective-study
#16
Christina A Muzny, Eugene Blanchard, Christopher M Taylor, Kristal J Aaron, Rajesh Talluri, Michael E Griswold, David T Redden, Meng Luo, David A Welsh, William J Van Der Pol, Elliot J Lefkowitz, David H Martin, Jane R Schwebke
Objective: To determine the sequence of events preceding incident BV (iBV). Methods: African American women who have sex with women (AAWSW) with no Amsel criteria and Nugent score 0-3 were followed for iBV (Nugent score 7-10 on at least 2-3 consecutive days) with self-collected vaginal swabs for 90 days. For women with iBV and women maintaining normal vaginal flora, 16S rRNA gene sequencing targeting V4 was performed. Longitudinal vaginal microbiome data were analyzed...
April 28, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29709092/the-vaginal-microbiome-amplifies-sex-hormone-associated-cyclic-changes-in-cervicovaginal-inflammation-and-epithelial-barrier-disruption
#17
Frideborg Bradley, Kenzie Birse, Klara Hasselrot, Laura Noël-Romas, Andrea Introini, Hugo Wefer, Maike Seifert, Lars Engstrand, Annelie Tjernlund, Kristina Broliden, Adam D Burgener
PROBLEM: Susceptibility to HIV is associated with the menstrual cycle and vaginal microbiome, but their collective impact on vaginal inflammation remains unclear. Here, we characterized the cervicovaginal proteome, inflammation, and microbiome community structure and function during the menstrual cycle. METHOD OF STUDY: Cervicovaginal secretions were collected from regularly cycling women (n = 16) at median day 10, 16, and 24 of each menstrual cycle and analyzed by mass spectrometry, 16S rRNA gene sequencing, and a multiplex bead array immunoassay...
April 30, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29705211/assessment-of-microbiota-host-interactions-at-the-vaginal-mucosa-interface
#18
REVIEW
Pamela Pruski, Holly V Lewis, Yun S Lee, Julian R Marchesi, Phillip R Bennett, Zoltan Takats, David A MacIntyre
There is increasing appreciation of the role that vaginal microbiota play in health and disease throughout a woman's lifespan. This has been driven partly by molecular techniques that enable detailed identification and characterisation of microbial community structures. However, these methods do not enable assessment of the biochemical and immunological interactions between host and vaginal microbiota involved in pathophysiology. This review examines our current knowledge of the relationships that exist between vaginal microbiota and the host at the level of the vaginal mucosal interface...
April 26, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29704918/microbiota-drug-interactions-impact-on-metabolism-and-efficacy-of-therapeutics
#19
REVIEW
Ellen M Wilkinson, Zehra Esra Ilhan, Melissa M Herbst-Kralovetz
The microbiome not only represents a vital modifier of health and disease, but is a clinically important drug target. Therefore, study of the impact of the human microbiome on drug metabolism, toxicity and efficacy is urgently needed. This review focuses on gut and vaginal microbiomes, and the effect of those microbiomes or components thereof on the pharmacokinetics of specific chemotherapeutic agents, immunotherapies, anti-inflammatory and antimicrobial drugs. In some cases, the presence of specific bacterial species within the microbiome can alter the metabolism of certain drugs, such as chemotherapeutic agents and antiviral drugs...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29688458/preterm-infants-have-distinct-microbiomes-not-explained-by-mode-of-delivery-breastfeeding-duration-or-antibiotic-exposure
#20
Cecilie Dahl, Hein Stigum, Jørgen Valeur, Nina Iszatt, Virissa Lenters, Shyamal Peddada, Jørgen V Bjørnholt, Tore Midtvedt, Siddhartha Mandal, Merete Eggesbø
Background: Preterm infants have low gut microbial diversity and few anaerobes. It is unclear whether the low diversity pertains to prematurity itself or is due to differences in delivery mode, feeding mode or exposure to antibiotics. Methods: The Norwegian Microbiota Study (NoMIC) was established to examine the colonization of the infant gut and health outcomes. 16S rRNA gene Illumina amplicon-sequenced samples from 519 children (160 preterms), collected at 10 days, 4 months and 1 year postnatally, were used to calculate alpha diversity...
April 20, 2018: International Journal of Epidemiology
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