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Neisseria gonorrhoeae

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https://www.readbyqxmd.com/read/28098538/neisseria-meningitidis-st11-complex-isolates-associated-with-nongonococcal-urethritis-indiana-usa-2015-2016
#1
Evelyn Toh, Dharanesh Gangaiah, Byron E Batteiger, James A Williams, Janet N Arno, Albert Tai, Teresa A Batteiger, David E Nelson
At a clinic in Indianapolis, Indiana, USA, we observed an increase in Neisseria gonorrhoeae-negative men with suspected gonococcal urethritis who had urethral cultures positive for N. meningitidis. We describe genomes of 2 of these N. meningitidis sequence type 11 complex urethritis isolates. Clinical evidence suggests these isolates may represent an emerging urethrotropic clade.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28094065/risk-factors-for-antimicrobial-resistant-neisseria-gonorrhoeae-and-characteristics-of-patients-infected-with-gonorrhea
#2
Irene Fuertes de Vega, Carola Baliu-Piqué, Jordi Bosch Mestres, Andrea Vergara Gómez, Xavier Vallés, Mercè Alsina Gibert
BACKGROUND: There are very few data available regarding risk factors associated with antibiotic resistant-Neisseria gonorrhoeae. METHODS: A study was conducted on 110 samples from 101 patients with gonococcal infection, in order to describe their characteristics and compare them with the antimicrobial susceptibility profile of their samples. RESULTS: An association was observed between resistant infections and heterosexual men, older age, concurrent sexually transmitted infection, and unsafe sexual behaviors...
January 13, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28079519/trends-in-antimicrobial-susceptibility-for-azithromycin-and-ceftriaxone-in-neisseria-gonorrhoeae-isolates-in-amsterdam-the-netherlands-between-2012-and-2015
#3
Carolien M Wind, Maarten F Schim van der Loeff, Alje P van Dam, Henry Jc de Vries, Jannie J van der Helm
Resistance of Neisseria gonorrhoeae to azithromycin and ceftriaxone has been increasing in the past years. This is of concern since the combination of these antimicrobials is recommended as the first-line treatment option in most guidelines. To analyse trends in antimicrobial resistance, we retrospectively selected all consultations with a positive N. gonorrhoeae culture at the sexually transmitted infection clinic, Amsterdam, the Netherlands, from January 2012 through September 2015. Minimum inhibitory concentrations (MICs) for azithromycin and ceftriaxone were analysed per year, and determinants associated with decreased susceptibility to azithromycin (MIC > 0...
January 5, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28077695/stability-studies-on-dry-swabs-and-wet-mailed-swabs-for-the-detection-of-c-trachomatis-and-n-gonorrhoeae-in-the-aptima-assays
#4
Jeanne Moncada, Carey B Clark, Jeffrey Holden, Edward W Hook, Charlotte A Gaydos, Julius Schachter
The Aptima Combo2 (AC2) and Aptima CT (ACT) (Hologic Inc., San Diego, CA) are nucleic acid amplified tests (NAATs) that detect Chlamydia trachomatis (CT). AC2 also detects Neisseria gonorrhoeae (NG). Storage and temperature conditions may impact the utility of NAATs in some settings and screening programs. We evaluated specimen stability for use beyond the Aptima package insert temperature and duration of storage specifications (between 2° to 30°C, 60 days) in two studies: 1) dry CT seeded swabs were used with ACT after storage at 4°C, 23°C or 36°C for up to 84 days and 2) swabs seeded with CT and NG then placed in transport media were tested with AC2, after mailing via the U...
January 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28073612/gonorrhea-and-chlamydia-in-the-emergency-department-continued-need-for-more-focused-treatment-for-men-women-and-pregnant-women
#5
Sean P Wilson, Taher Vohra, McKenna Knych, Jared Goldberg, Christopher Price, Sean Calo, Meredith Mahan, Joseph Miller
INTRODUCTION: Delay in current nucleic acid amplification testing for Neisseria gonorrhoeae and Chlamydia trachomatis has led to recommendations for presumptive treatment in patients with concern for infection and unreliable follow-up. In the urban setting, it is assumed that many patients have unreliable follow-up, therefore presumptive therapy is thought to be used frequently. We sought to measure the frequency of disease and accuracy of presumptive treatment for these infections. METHODS: This was an observational cohort study performed at an urban academic Level 1 trauma center ED with an annual census of 95,000 visits per year...
January 3, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28072668/genital-and-extragenital-gonorrhea-and-chlamydia-in-children-and-adolescents-evaluated-for-sexual-abuse
#6
Nancy D Kellogg, John D Melville, James L Lukefahr, Shalon M Nienow, Edward L Russell
OBJECTIVE: The aim of this study was to describe the use of a nucleic acid amplification test in detecting genital and extragenital Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) in children and adolescents assessed for sexual abuse/assault. METHODS: The charts of children aged 0 to 17 years, consecutively evaluated for sexual victimization, in emergency department and outpatient settings were reviewed. Data extracted included age, sex, type of sexual contact, anogenital findings, previous sexual contact, toxicology results, and sites tested for NG and CT...
January 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28072403/antimicrobial-resistant-sexually-transmitted-infections-gonorrhoea-and-mycoplasma-genitalium
#7
REVIEW
Magnus Unemo, Jorgen S Jensen
The emergence of antimicrobial resistance (AMR) is a major concern worldwide and already compromises treatment effectiveness and control of several bacterial sexually transmitted infections (STIs). Neisseria gonorrhoeae and Mycoplasma genitalium are evolving into so-called superbugs that can become resistant, both in vitro and clinically, to essentially all antimicrobials available for treatment, causing exceedingly difficult-to-treat or untreatable STIs and threatening global public health. Widespread AMR in these bacteria is likely to persist and even worsen in the future, owing to the high number of infections, widespread and uncontrolled use of antimicrobials, limited surveillance of AMR and clinical failures, as well as the extraordinary capacity of these bacteria to develop AMR...
January 10, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28069643/gepotidacin-gsk2140944-in-vitro-activity-against-neisseria-gonorrhoeae-mic-mbc-kill-kinetics-checkerboard-pae-sme-tests
#8
D J Farrell, H S Sader, P R Rhomberg, N E Scangarella-Oman, R K Flamm
Gepotidacin, (formerly GSK2140944) is a novel, first in class, triazaacenaphthylene antibacterial, which inhibits bacterial DNA gyrase and topoisomerase IV via a unique mechanism and has demonstrated in vitro activity against Neisseria gonorrhoeae, including drug-resistant strains, and also target pathogens associated with other conventional and biothreat infections. Broth microdilution was used to evaluate the minimum inhibitory/bactericidal concentration (MIC/MBC) activity of gepotidacin and comparators against 25 N...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28068218/comparison-of-self-collected-meatal-swabs-with-urine-specimens-for-the-diagnosis-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-men
#9
Lisa Berry, Belinda Stanley
Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) are common bacterial causes of sexually transmitted infection. Self-taken meatal swabs are a possible alternative to urine samples in testing for infection; however the data surrounding their use are limited. We carried out a prospective service review in a large sexual health clinic comparing urine samples and self-taken meatal swabs in men presenting for sexual transmissible infection screening for CT and GC with the BD Viper XTR system. We found an overall prevalence of CT infections was 10...
January 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28063198/functional-and-structural-studies-on-the-neisseria-gonorrhoeae-gmha-the-first-enzyme-in-the-glycero-manno-heptose-biosynthesis-pathways-demonstrate-a-critical-role-in-lipooligosaccharide-synthesis-and-gonococcal-viability
#10
Igor H Wierzbicki, Ryszard A Zielke, Konstantin V Korotkov, Aleksandra E Sikora
Sedoheptulose-7-phosphate isomerase, GmhA, is the first enzyme in the biosynthesis of nucleotide-activated-glycero-manno-heptoses and an attractive, yet underexploited, target for development of broad-spectrum antibiotics. We demonstrated that GmhA homologs in Neisseria gonorrhoeae and N. meningitidis (hereafter called GmhAGC and GmhANM , respectively) were interchangeable proteins essential for lipooligosaccharide (LOS) synthesis, and their depletion had adverse effects on neisserial viability. In contrast, the Escherichia coli ortholog failed to complement GmhAGC depletion...
January 7, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28052997/human-three-dimensional-endometrial-epithelial-cell-model-to-study-host-interactions-with-vaginal-bacteria-and-neisseria-gonorrhoeae
#11
Paweł Łaniewski, Adriana Gomez, Geoffrey Hire, Magdalene So, Melissa M Herbst-Kralovetz
Colonization of the endometrium by pathogenic bacteria, ascending from the lower female reproductive tract (FRT), is associated with many gynecologic and obstetric health complications. To study these host-microbe interactions in vitro, we developed a human three-dimensional (3-D) endometrial epithelial cell (EEC) model using the HEC-1A cell line and rotating wall vessel (RWV) bioreactor technology. Our model, composed of 3-D EEC aggregates, recapitulates several functional/structural characteristics of human endometrial epithelial tissue including cell differentiation, junctional complexes/desmosomes, microvilli, membrane-associated mucins and Toll-like receptors (TLRs)...
January 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28038960/use-of-whole-genome-sequencing-data-to-analyze-23s-rrna-mediated-azithromycin-resistance
#12
Steven R Johnson, Yonatan Grad, A Jeanine Abrams, Kevin Pettus, David L Trees
The whole-genome sequences of 24 isolates of Neisseria gonorrhoeae with elevated minimum inhibitory concentrations (MICs) to azithromycin (≥2.0 µg/mL) were analyzed against a modified sequence derived from the whole-genome sequence of N. gonorrhoeae FA1090 to determine, by signal ratio, the number of mutant copies of the 23S rRNA gene and the copy number effect on 50S ribosome-mediated azithromycin resistance. Isolates that were predicted to contain four mutated copies were accurately identified compared with the results of direct sequencing...
December 19, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28035227/plasmid-mediated-resistance-to-tetracyclines-among-neisseria-gonorrhoeae-strains-isolated-in-poland-between-2012-and-2013
#13
Beata Młynarczyk-Bonikowska, Marlena Kujawa, Magdalena Malejczyk, Grażyna Młynarczyk, Sławomir Majewski
INTRODUCTION: One of two main mechanisms of resistance in tetracycline-resistant Neisseria gonorrhoeae (TRNG) is associated with the presence of TetM protein responsible for actively blocking of the tetracycline target site in the 30S ribosomal subunit. This mechanism is encoded by conjugative plasmids. The second mechanism is chromosomal in nature and due to mutations in specific genes. AIM: To determine the incidence and type of tetM determinants in TRNG strains isolated from patients presenting with gonorrhea infection to the Dermatology and Venereology Clinic in Warsaw in 2012-2013...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28034887/implementation-of-a-rapid-genotypic-assay-to-promote-targeted-ciprofloxacin-therapy-of-neisseria-gonorrhoeae-in-a-large-health-system
#14
Lao-Tzu Allan-Blitz, Romney M Humphries, Peera Hemarajata, Ashima Bhatti, Mark W Pandori, Mark J Siedner, Jeffrey D Klausner
Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.
December 28, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28007229/sexually-transmitted-diseases-and-infertility
#15
REVIEW
Danielle G Tsevat, Harold C Wiesenfeld, Caitlin Parks, Jeffrey F Peipert
Female infertility, including tubal factor infertility, is a major public health concern worldwide. Most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. Evidence has consistently demonstrated the effects of Chlamydia trachomatis and Neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor infertility and pelvic inflammatory disease...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28006003/genital-chlamydia-trachomatis-infection-among-women-of-reproductive-age-attending-the-gynecology-clinic-of-hawassa-university-referral-hospital-southern-ethiopia
#16
Endale Tadesse, Million Teshome, Anteneh Amsalu, Techalew Shimelis
BACKGROUND: Urogenital infection with Chlamydia trachomatis(CT) is one of the most common bacterial sexually transmitted infections (STIs) world-wide, especially in developing nations where routine laboratory diagnosis is unavailable. Little is known about the epidemiology of this infection in Ethiopia where other STIs are prevalent. This study was conducted to determine the prevalence and associated factors of CT infection among women of reproductive age. METHODS: A cross-sectional study was conducted among 322 consecutive women aged between 15-49 years at Hawassa University Referral Hospital from November 2014 to April 2015...
2016: PloS One
https://www.readbyqxmd.com/read/28002109/neonatal-bacterial-conjunctivitis-in-korea-in-the-21st-century
#17
Kang Yeun Pak, Sung Il Kim, Jong Soo Lee
PURPOSE: To investigate the microbial cause and antibiotic susceptibility of neonatal bacterial conjunctivitis in Korean patients in the 21st century. METHODS: We retrospectively reviewed the medical records of patients diagnosed with neonatal bacterial conjunctivitis between January 2000 and December 2015. We recorded the organism, antibiotic susceptibility, and antibiotics used. RESULTS: A total of 82 neonates were included in the study (53 males and 29 females), with a mean age of 17...
December 20, 2016: Cornea
https://www.readbyqxmd.com/read/27999043/changes-in-the-rates-of-neisseria-gonorrhoeae-antimicrobial-resistance-are-primarily-driven-by-dynamic-fluctuations-in-common-gonococcal-genotypes
#18
Monica M Lahra, Ella Trembizki, Cameron Buckley, Basil Donovan, Marcus Chen, Rebecca Guy, Ratan L Kundu, David G Regan, David M Whiley
OBJECTIVES: To examine how gonococcal genotypes and associated changes over time influence rates of Neisseria gonorrhoeae antimicrobial resistance. METHODS: All available N. gonorrhoeae isolates collected in New South Wales, Australia in the first half of both 2012 and 2014 were genotyped using the Agena MassARRAY iPLEX platform. Genotypic data were compared with phenotypic antimicrobial resistance profiles over time. We focused on penicillin and ciprofloxacin as significant increases in resistance to both antibiotics were observed over this time period...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27998950/antiseptic-mouthwash-against-pharyngeal-neisseria-gonorrhoeae-a-randomised-controlled-trial-and-an-in-vitro-study
#19
Eric Pf Chow, Benjamin P Howden, Sandra Walker, David Lee, Catriona S Bradshaw, Marcus Y Chen, Anthony Snow, Stuart Cook, Glenda Fehler, Christopher K Fairley
BACKGROUND: Gonorrhoea is increasing among men who have sex with men (MSM). We aimed to determine whether Listerine, a commercial mouthwash product, has an inhibitory effect against Neisseria gonorrhoeae in a randomised controlled trial (RCT) and an in vitro study, and therefore may be a potentially useful agent for gonorrhoea control. METHODS: In vitro: a suspension of ∼10(8) colony forming units per mL (CFU/mL) of N. gonorrhoeae was added to a serial of dilutions (up to 1:32) of alcohol-containing Listerine mouthwashes (Cool Mint and Total Care) for 1 min...
December 20, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27981386/-non-viral-sexually-transmitted-infections-epidemiology-clinical-manifestations-diagnostics-and-therapy-part%C3%A2-1-gonococci
#20
REVIEW
P Nenoff, A Manos, I Ehrhard, C Krüger, U Paasch, P Helmbold, W Handrick
Approximately 1 million people are infected per day worldwide by one or more sexually transmitted infections (STI) as estimated by the World Health Organization (WHO). Gonorrhoea represents an almost exclusively sexually transmitted infection, which predominantly affects mucous membranes of the genitourinary tract. Extragenital localization of infections is also possible, e. g. in the anorectal region. Currently, only syphilis and human immunodeficiency virus (HIV) are notifiable diseases according to the Infection Protection Act in Germany...
December 15, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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