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Neisseria gonorrhoeae

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https://www.readbyqxmd.com/read/28646898/prevalence-of-chlamydia-trachomatis-neisseria-gonorrhoeae-mycoplasma-genitalium-and-ureaplasma-urealyticum-infections-using-a-novel-isothermal-simultaneous-rna-amplification-testing-method-in-infertile-males
#1
Ling Qing, Qi-Xiang Song, Jian-Li Feng, Hai-Yan Li, Guiming Liu, Hai-Hong Jiang
BACKGROUND: The purpose of this study was to evaluate the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Ureaplasma urealyticum infections in infertile men that consulted our outpatient departments using a novel simultaneous amplification testing (SAT) that is RNA-detection based. The possible impact of C. trachomatis, N. gonorrhoeae, M. genitalium and U. urealyticum infections on semen parameters was also noted in the present study. METHODS: A total of 2607 males that were diagnosed with infertility were included in this study...
June 24, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28645177/mobile-genetic-elements-in-neisseria-gonorrhoeae-movement-for-change
#2
Ana Cehovin, Steven B Lewis
Neisseria gonorrhoeae, the causative agent of the sexually transmitted disease gonorrhoeae, possesses several mobile genetic elements (MGEs). The MGEs such as transposable elements mediate intra-chromosomal rearrangements, while plasmids and the gonococcal genetic island are involved in inter-chromosomal gene transfer. Additionally, gonococcal MGEs serve as hotspots for recombination and integration of other genetic elements such as bacteriophages, contribute to gene regulation or spread genes through gonococcal populations by horizontal gene transfer...
June 22, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28638824/dual-epidemics-of-club-drug-use-and-sexually-transmitted-infections-among-chinese-female-sex-workers-new-challenges-to-sti-prevention
#3
Jing Li, Xiang-Dong Gong, Xiaoli Yue, Ning Jiang
OBJECTIVES: To evaluate club drug use and its potential association with STI among female sex workers (FSWs) in China. METHODS: From November 2008 to January 2009, participants were recruited at sex work venues in five cities for a questionnaire survey. Free testing for syphilis, Chlamydia trachomatis (CT), and Neisseria gonorrhoeae (NG) was provided. Logistic regression models were used to assess factors associated with club drug use and its association with STI...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28637523/ureaplasma-urealyticum-and-u-parvum-in-sexually-active-women-attending-public-health-clinics-in-brazil
#4
T N Lobão, G B Campos, N N Selis, A T Amorim, S G Souza, S S Mafra, L S Pereira, D B Dos Santos, T B Figueiredo, L M Marques, J Timenetsky
Ureaplasma urealyticum and U. parvum have been associated with genital infections. The purpose of this study was to detect the presence of ureaplasmas and other sexually transmitted infections in sexually active women from Brazil and relate these data to demographic and sexual health, and cytokines IL-6 and IL-1β. Samples of cervical swab of 302 women were examined at the Family Health Units in Vitória da Conquista. The frequency of detection by conventional PCR was 76·2% for Mollicutes. In qPCR, the frequency found was 16·6% for U...
June 22, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28636866/prevalence-and-risk-factors-of-chlamydia-trachomatis-neisseria-gonorrhoeae-trichomonas-vaginalis-and-other-sexually-transmissible-infections-among-women-attending-antenatal-clinics-in-three-provinces-in-papua-new-guinea-a-cross-sectional-survey
#5
Lisa M Vallely, Pamela Toliman, Claire Ryan, Glennis Rai, Johanna Wapling, Carolyn Tomado, Savarina Huliafi, Gloria Munnull, Patricia Rarau, Suparat Phuanukoonnon, Handan Wand, Peter Siba, Glen D L Mola, John M Kaldor, Andrew J Vallely
Background Papua New Guinea (PNG) is estimated to have among the highest prevalences of HIV and sexually transmissible infections (STIs) of any Asia-Pacific country, and one of the highest burdens of maternal syphilis globally. The prevalence of curable STIs, such as Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV), among pregnant women in PNG is relatively unknown. METHODS: A cross-sectional bio-behavioural survey to investigate the epidemiology of CT, NG, TV and other STIs among pregnant women in three provinces of PNG was undertaken...
October 2016: Sexual Health
https://www.readbyqxmd.com/read/28633281/the-sweet-side-of-the-pathogenic-neisseria-the-role-of-glycan-interactions-in-colonisation-and-disease
#6
Tsitsi D Mubaiwa, Evgeny A Semchenko, Lauren E Hartley-Tassell, Christopher J Day, Michael P Jennings, Kate L Seib
Glycomics is a rapidly growing field that focuses on the structure and function of carbohydrates (glycans) in biological systems. Glycan interactions play a major role in infectious disease, at all stages of colonisation and disease progression. Neisseria meningitidis, the cause of meningococcal sepsis and meningitis, and Neisseria gonorrhoeae, which causes the sexually transmitted infection gonorrhoea, are responsible for significant morbidity and mortality worldwide. N. meningitidis displays a range of surface glycosylations including capsule polysaccharide, lipooligosaccharide and O-linked glycoproteins...
June 13, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28632191/sexually-transmitted-infections-a-novel-screening-strategy-for-improving-women-s-health-in-vulnerable-populations
#7
Elena R Frati, Ester Fasoli, Marianna Martinelli, Daniela Colzani, Silvia Bianchi, Luciana Carnelli, Antonella Amendola, Pierfranco Olivani, Elisabetta Tanzi
BACKGROUND: Migrant women are one of the most vulnerable population to health problems and well-being. This study aimed at implementing a counseling and preventive strategy for sexually transmitted infections (STIs) in undocumented migrant women in Milan, Italy. METHODS: Women (ages 18-65) were enrolled at the NAGA Centre (2012-2013) and asked for a urine sample in order to carry out molecular detection of Human papillomavirus (HPV), Chlamydia trachomatis (Ct), Trichomonas vaginalis (Tv), Neisseria gonorrhoeae (Ng)-DNA...
June 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28630127/deciphering-function-of-new-gonococcal-vaccine-antigens-using-phenotypic-microarrays
#8
Benjamin I Baarda, Sarah Emerson, Philip J Proteau, Aleksandra E Sikora
The function and extracellular location of cell envelope proteins make them attractive candidates for developing vaccines against bacterial diseases, including challenging, drug-resistant pathogens such as Neisseria gonorrhoeae Proteomics-driven reverse vaccinology delivered multiple gonorrhea vaccine candidates; however, the biological functions of many of them remain to be elucidated. Herein, the functions of six gonorrhea vaccine candidates - NGO2121, NGO1985, NGO2054, NGO2111, NGO1205, and NGO1344 - in cell envelope homeostasis were probed using phenotype microarrays with 1,056 conditions and a ΔbamE mutant (Δngo1780) as a reference of perturbed outer membrane integrity...
June 19, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28629687/sensitivity-and-specificity-of-empiric-treatment-for-sexually-transmitted-infections-in-a-pediatric-emergency-department
#9
Kristen Breslin, Lisa Tuchman, Katie L Hayes, Gia Badolato, Monika K Goyal
OBJECTIVE: To determine test characteristics of provider judgment for empiric antibiotic provision to patients undergoing testing for a sexually transmitted infection. STUDY DESIGN: We conducted a retrospective cross-sectional electronic health record review of all patients aged 13-19 years who had Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) testing sent from an urban, academic pediatric emergency department in 2012. We abstracted data, including patient demographics, chief complaint, sexually transmitted infection test results, and treatment...
June 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28615273/analysis-of-the-potential-for-point-of-care-test-to-enable-individualised-treatment-of-infections-caused-by-antimicrobial-resistant-and-susceptible-strains-of-neisseria-gonorrhoeae-a-modelling-study
#10
Katy Me Turner, Hannah Christensen, Elisabeth J Adams, David McAdams, Helen Fifer, Anthony McDonnell, Neil Woodford
OBJECTIVE: To create a mathematical model to investigate the treatment impact and economic implications of introducing an antimicrobial resistance point-of-care test (AMR POCT) for gonorrhoea as a way of extending the life of current last-line treatments. DESIGN: Modelling study. SETTING: England. POPULATION: Patients accessing sexual health services. INTERVENTIONS: Incremental impact of introducing a hypothetical AMR POCT that could detect susceptibility to previous first-line antibiotics, for example, ciprofloxacin or penicillin, so that patients are given more tailored treatment, compared with the current situation where all patients are given therapy with ceftriaxone and azithromycin...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28608788/increases-in-the-rate-of-neisseria-gonorrhoeae-among-gay-bisexual-and-other-men-who-have-sex-with-men-findings-from-the-sexually-transmitted-disease-surveillance-network-2010-2015
#11
Mark R Stenger, Preeti Pathela, Greta Anschuetz, Heidi Bauer, Julieann Simon, Robert Kohn, Christina Schumacher, Elizabeth Torrone
BACKGROUND: Inequalities in Neisseria gonorrhoeae (gonorrhea) burden by sexual minority status in the United States are difficult to quantify. Sex of sex partner is not routinely collected for reported cases. Population estimates of men who have sex with men (MSM) necessary to calculate case rates have not been available until recently. For these reasons, trends in reported gonorrhea rates among MSM have not been described across multiple jurisdictions. METHODS: We estimated of the number of MSM cases reported in 6 jurisdictions continuously participating in the STD Surveillance Network 2010-2015 based on interviews with a random sample of cases...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28607013/pena-pona-porb1-and-mtrr-mutations-and-molecular-epidemiological-typing-of-neisseria-gonorrhoeae-with-decreased-susceptibility-to-cephalosporin
#12
Kayo Osawa, Katsumi Shigemura, Yukie Nukata, Koichi Kitagawa, Fukashi Yamamichi, Hiroyuki Yoshida, Toshiro Shirakawa, Soichi Arakawa, Masato Fujisawa
In recent years, N. gonorrhoeae strains with decreased susceptibilities (DS; MIC > 0.064 mg/L) or resistance to cefixime (CFM) or ceftriaxone (CRO), have been classed as a "superbug" and have spread worldwide, resulting in treatment failures for gonorrhea (1-3).….
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28604481/comparative-evaluation-of-2-nucleic-acid-amplification-tests-for-the-detection-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-at-extragenital-sites
#13
Claire C Bristow, Mark R McGrath, Adam C Cohen, Laura J Anderson, Kristie K Gordon, Jeffrey D Klausner
Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections are frequently asymptomatic, requiring highly accurate diagnostic tests and proper management to prevent further transmission. We compared two nucleic acid tests, Xpert® CT/NG (Cepheid, Sunnyvale, CA) point-of-care platform and at an offsite clinical laboratory with Aptima Combo 2® (Hologic, Inc., San Diego, CA) assay, for the detection of extragenital infection in patients at an STI clinic in Hollywood, CA.We calculated concordance between the two assays and used the exact binomial method to calculate 95% confidence intervals (CIs) for each specimen type and pathogen...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28596392/fourteen-draft-genome-sequences-for-the-first-reported-cases-of-azithromycin-resistant-neisseria-gonorrhoeae-in-ireland
#14
Micheál Mac Aogáin, Nicholas Fennelly, Anne Walsh, Yvonne Lynagh, Michaël Bekaert, Brendan Lawlor, Paul Walsh, Brian Kelly, Thomas R Rogers, Brendan Crowley
Here, we report the draft genome assemblies of 14 azithromycin-resistant Neisseria gonorrhoeae clinical isolates, representing the first such strains identified in Ireland. Among these isolates are the first reported highly resistant strains (MIC >256 mg/liter), which both belonged to the ST1580 sequence type.
June 8, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28591853/neisseria-genomics-current-status-and-future-perspectives
#15
Odile B Harrison, Christoph Schoen, Adam C Retchless, Xin Wang, Keith A Jolley, James E Bray, Martin C J Maiden
High-throughput whole genome sequencing has unlocked a multitude of possibilities enabling members of the Neisseria genus to be examined with unprecedented detail, including the human pathogens Neisseria meningitidis and Neisseria gonorrhoeae. To maximise the potential benefit of this for public health, it is becoming increasingly important to ensure that this plethora of data are adequately stored, disseminated and made readily accessible. Investigations facilitating cross-species comparisons as well as the analysis of global datasets will allow differences among and within species and across geographic locations and different times to be identified, improving our understanding of the distinct phenotypes observed...
June 7, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28590237/evaluation-of-self-collected-rectal-swabs-for-the-detection-of-bacteria-responsible-for-sexually-transmitted-infections-in-a-cohort-of-hiv-1-infected-patients
#16
Sophie Edouard, Catherine Tamalet, Hervé Tissot-Dupont, Philippe Colson, Amélie Ménard, Isabelle Ravaux, Catherine Dhiver, Christelle Tomei, Andreas Stein, Didier Raoult
PURPOSE: The standard approach to screening sexually transmitted infections (STIs) has often been restricted to urogenital specimens. Most current guidelines, however, also recommend testing extra-genital sites, including rectal locations, because asymptomatic rectal carriage of pathogens has often been reported. The aim of our study was to evaluate self-collected rectal swabs to screen bacterial STIs in HIV-infected patients in Marseille, France. METHODOLOGY: Between January 2014 and December 2015, 118 HIV-infected patients (93 males and 25 females) agreed to self-sample anal swabs for detection of bacterial STI...
June 8, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28585815/neisseria-gonorrhoeae-lytic-transglycosylases-ltga-and-ltgd-reduce-host-innate-immune-signaling-through-tlr2-and-nod2
#17
Kayla J Knilans, Kathleen T Hackett, James E Anderson, Chengyu Weng, Joseph P Dillard, Joseph A Duncan
Neisseria gonorrhoeae releases anhydro peptidoglycan monomers during growth through the action of two lytic transglycosylases encoded in the N. gonorrhoeae genome, LtgA and LtgD. Because peptidoglycan and peptidoglycan components activate innate immune signaling, we hypothesized that the activity of LtgA and LtgD would influence the host responses to gonococcal infection. N. gonorrhoeae lacking LtgA and LtgD caused increased host production of inflammatory cytokines IL-1β and TNF-α. Culture supernatants from ΔltgA/ΔltgD N...
June 21, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28584144/peptide-inhibitors-targeting-the-neisseria-gonorrhoeae-pivotal-anaerobic-respiration-factor-ania
#18
Aleksandra E Sikora, Robert H Mills, Jacob V Weber, Adel Hamza, Bryan W Passow, Andrew Romaine, Zachary A Williamson, Robert W Reed, Ryszard A Zielke, Konstantin V Korotkov
Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea, which is highly prevalent worldwide and has a major impact on reproductive and neonatal health. The "superbug" status of N. gonorrhoeae necessitates development of drugs with different mechanisms of action. Here, we focused on targeting the nitrite reductase AniA, which is a pivotal component of N. gonorrhoeae anaerobic respiration and biofilm formation. Our studies showed that gonococci expressing AniA containing altered catalytic residues, D137A and H280A, failed to grow under anaerobic conditions demonstrating that the nitrite reductase function is essential...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28583150/prevalence-of-pregnancy-relevant-infections-in-a-rural-setting-of-ghana
#19
Fabian Völker, Paul Cooper, Oliver Bader, Angela Uy, Ortrud Zimmermann, Raimond Lugert, Uwe Groß
BACKGROUND: Although infectious diseases still account for a high burden of morbidity and mortality in sub-Saharan Africa, simultaneous investigations on multiple infections affecting maternal and child health are missing. METHODS: We conducted a cross-sectional, single-centre pilot study in a rural area of Ghana to assess the infectiological profile during pregnancy. Screening of 180 expectant mothers was done by vaginal swabs and serology to detect the most common pregnancy-relevant infections...
June 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28581359/in-vitro-activity-of-sitafloxacin-and-additional-newer-generation-fluoroquinolones-against-ciprofloxacin-resistant-neisseria-gonorrhoeae-isolates
#20
Ryoichi Hamasuna, Makoto Ohnishi, Masahiro Matsumoto, Ryo Okumura, Magnus Unemo, Tetsuro Matsumoto
Emergence of antimicrobial resistance in Neisseria gonorrhoeae is a major public health concern globally, and new antimicrobials for treatment of gonorrhea are imperative. In this study, the in vitro activity of sitafloxacin, a fluoroquinolone mainly used for respiratory tract or urogenital infections in Japan, and additional newer generation fluoroquinolones were determined against ciprofloxacin-resistant N. gonorrhoeae isolates. Minimum inhibitory concentrations (MICs) of ciprofloxacin, levofloxacin, moxifloxacin, sitafloxacin, pazufloxacin, and tosufloxacin against 47 N...
June 5, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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