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Lactoferrin

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https://www.readbyqxmd.com/read/29238342/breastfeeding-behaviors-and-the-innate-immune-system-of-human-milk-working-together-to-protect-infants-against-inflammation-hiv-1-and-other-infections
#1
REVIEW
Bethany M Henrick, Xiao-Dan Yao, Laila Nasser, Ava Roozrogousheh, Kenneth L Rosenthal
The majority of infants' breastfeeding from their HIV-infected mothers do not acquire HIV-1 infection despite exposure to cell-free virus and cell-associated virus in HIV-infected breast milk. Paradoxically, exclusive breastfeeding regardless of the HIV status of the mother has led to a significant decrease in mother-to-child transmission (MTCT) compared with non-exclusive breastfeeding. Although it remains unclear how these HIV-exposed infants remain uninfected despite repeated and prolonged exposure to HIV-1, the low rate of transmission is suggestive of a multitude of protective, short-lived bioactive innate immune factors in breast milk...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29222991/salivary-immune-proteins-monitoring-can-help-detection-of-binge-and-chronic-alcohol-drinkers-preliminary-findings
#2
Napoleon Waszkiewicz, Beata Galińska-Skok, Anna Zalewska, Sławomir Dariusz Szajda, Krzysztof Zwierz, Magdalena Więdłocha, Agata Szulc
BACKGROUND: We compared effects of binge and chronic alcohol drinking on oral health and salivary immunity proteins. METHODS: The study involved males: 13 healthy social-drinking (C), 10 alcohol-dependent after chronic alcohol-intoxication (A), and 8 binge-drinkers after a single binge-drinking session (B). We compared periodontal/dental state and salivary immune proteins (lactoferrin -Lf, lysozyme -Lz, oral peroxidase -OPO, immunoglobulin A -IgA) in all groups...
December 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29214534/development-of-a-sandwich-elisa-with-potential-for-selective-quantification-of-human-lactoferrin-protein-nitrated-through-disease-or-environmental-exposure
#3
Amani Y Alhalwani, John E Repine, Michelle K Knowles, J Alex Huffman
Lactoferrin (LF) is an important multifunctional protein that comprises a large fraction of the protein mass in certain human fluids and tissues, and its concentration is often used to assess health and disease. LF can be nitrated by multiple routes, leading to changes in protein structure, and nitrated proteins can negatively impact physiological health via nitrosative stress. Despite an awareness of the detrimental effects of nitrated proteins and the importance of LF within the body, cost-effective methods for detecting and quantifying nitrated lactoferrin (NLF) are lacking...
December 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29198543/exposure-to-gastric-acid-inhibitors-increases-the-risk-of-infection-in-preterm-very-low-birth-weight-infants-but-concomitant-administration-of-lactoferrin-counteracts-this-effect
#4
Paolo Manzoni, Ruben García Sánchez, Michael Meyer, Ilaria Stolfi, Lorenza Pugni, Hubert Messner, Silvia Cattani, Pasqua Maria Betta, Luigi Memo, Lidia Decembrino, Lina Bollani, Matteo Rinaldi, Maria Fioretti, Michele Quercia, Milena Maule, Elena Tavella, Alessandro Mussa, Chryssoula Tzialla, Nicola Laforgia, Fabio Mosca, Rosario Magaldi, Michael Mostert, Daniele Farina
OBJECTIVE: To investigate whether exposure to inhibitors of gastric acidity, such as H2 blockers or proton pump inhibitors, can independently increase the risk of infections in very low birth weight (VLBW) preterm infants in the neonatal intensive care unit. STUDY DESIGN: This is a secondary analysis of prospectively collected data from a multicenter, randomized controlled trial of bovine lactoferrin (BLF) supplementation (with or without the probiotic Lactobacillus rhamnosus GG) vs placebo in prevention of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) in preterm infants...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29196676/efficiency-of-novel-nanocombinations-of-bovine-milk-proteins-lactoperoxidase-and-lactoferrin-for-combating-different-human-cancer-cell-lines
#5
Marwa M Abu-Serie, Esmail M El-Fakharany
Bovine lactoperoxidase (LPO) and lactoferrin (LF) are suitable proteins to be loaded or adsorbed to chitosan nanoparticles (NPs) for preparing stable nanoformulations with potent anticancer activity. In the present study, nanocombinations of LPO and LF revealed improvement in their stability and activity compared to single (free or nanoformulated) bovine proteins. The coating or loading of LPO-loaded NPs with LF resulted in the highest synergistic cytotoxicity effect against Caco-2, HepG-2, MCF-7 and PC-3 cells in comparison with other NPs and free proteins without causing toxicity toward normal cells...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29191424/receptor-mediated-targeted-delivery-of-dna-using-lactoferrin-nanoparticles
#6
Sonali Kumari, Anand Kumar Kondapi
Efficient gene delivery facilitated by non-viral vectors, is comparatively safer alternative than viral carriers. Current approaches to gene delivery largely depends on methods that overcome cellular and tissue barriers impeding efficient DNA delivery. While the conventional delivery systems have the drawback of low cellular uptake and off target effects, the receptor-mediated gene delivery system has shown remarkable breakthrough. In that context exploiting the specific receptor targeting properties of lactoferrin protein, we have developed pDNA loaded lactoferrin protein nanoparticles (pDNA-LfNPs)...
November 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29180990/the-n-terminus-of-human-lactoferrin-displays-anti-biofilm-activity-on-candida-parapsilosis-in-lumen-catheters
#7
Roberta Fais, Mariagrazia Di Luca, Cosmeri Rizzato, Paola Morici, Daria Bottai, Arianna Tavanti, Antonella Lupetti
Candida parapsilosis is a major cause of hospital-acquired infection, often related to parenteral nutrition administered via catheters and hand colonization of health care workers, and its peculiar biofilm formation ability on plastic surfaces. The mortality rate of 30% points to the pressing need for new antifungal drugs. The present study aimed at analyzing the inhibitory activity of the N-terminal lactoferrin-derived peptide, further referred to as hLF 1-11, against biofilms produced by clinical isolates of C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29165086/association-between-ltf-polymorphism-and-risk-of-hiv-1-transmission-among-zambian-seropositive-mothers
#8
Luisa Zupin, Vania Polesello, Ludovica Segat, Anselmo Jiro Kamada, Louise Kuhn, Sergio Crovella
BACKGROUND: Lactoferrin is a member of the innate immune system acting in the first line of defence against pathogens, and it is known for its antibacterial, antifungal and antiviral activity, including HIV-1. Two polymorphisms, T29A and R47K, in the exon 1 region of the LTF gene (encoding for the lactoferrin protein) were previously described as able to influence the lactoferrin antimicrobial function. OBJECTIVES: LTF T29A and R47K genetic variants were analysed in a Zambian population to unravel if these polymorphisms could play a role in HIV-1 mother-to-child HIV-1 transmission...
November 19, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29164069/iron-acquisition-mechanisms-and-their-role-in-the-virulence-of-burkholderia-species
#9
REVIEW
Aaron T Butt, Mark S Thomas
Burkholderia is a genus within the β-Proteobacteriaceae that contains at least 90 validly named species which can be found in a diverse range of environments. A number of pathogenic species occur within the genus. These include Burkholderia cenocepacia and Burkholderia multivorans, opportunistic pathogens that can infect the lungs of patients with cystic fibrosis, and are members of the Burkholderia cepacia complex (Bcc). Burkholderia pseudomallei is also an opportunistic pathogen, but in contrast to Bcc species it causes the tropical human disease melioidosis, while its close relative Burkholderia mallei is the causative agent of glanders in horses...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29163511/lactoferrin-in-a-context-of-inflammation-induced-pathology
#10
REVIEW
Marian L Kruzel, Michal Zimecki, Jeffrey K Actor
Much progress has been achieved to elucidate the function of lactoferrin (LTF), an iron-binding glycoprotein, in the milieu of immune functionality. This review represents a unique examination of LTF toward its importance in physiologic homeostasis as related to development of disease-associated pathology. The immunomodulatory nature of this protein derives from its unique ability to "sense" the immune activation status of an organism and act accordingly. Underlying mechanisms are proposed whereby LTF controls disease states, thereby pinpointing regions of entry for LTF in maintenance of various physiological pathways to limit the magnitude of tissue damage...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29155126/treatment-strategy-by-lactoperoxidase-and-lactoferrin-combination-immunomodulatory-and-antibacterial-activity-against-multidrug-resistant-acinetobacter-baumannii
#11
Likaa Mahdi, Nada Mahdi, Sana'a Al-Kakei, Hadeel Musafer, Ikbal Al-Joofy, Rajwa Essa, Luma Zwain, Istabreq Salman, Haifa Mater, Shaymaa Al-Alak, Rasha Al-Oqaili
Lactoperoxidase (Lpo) and Lactoferrin (Lf) were extracted from camel colostrum milk and purified. The antibacterial activity of the two purified proteins was estimated against 14 isolates of multidrug resistance Acinetobacter baumannii. A combination of Lpo and Lf exhibited bactericidal action against A. baumannii in vitro. A mouse model of acute A. baumannii pneumonia was improved. The injection of combined Lpo and Lf after infection leads to significant clearance of A. baumannii rates in lung as well as blood culture P < 0...
November 15, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29151693/endoscopic-balloon-dilation-of-crohn-s-disease-strictures-safety-efficacy-and-clinical-impact
#12
Susana Lopes, Eduardo Rodrigues-Pinto, Patrícia Andrade, Joana Afonso, Todd H Baron, Fernando Magro, Guilherme Macedo
AIM: To evaluate the incidence of anastomotic strictures after intestinal resection in Crohn's disease (CD), demonstrate long-term efficacy and safety of endoscopic balloon dilation (EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. METHODS: Retrospective single tertiary center study based on prospectively collected data between 2010 and 2015 including anastomotic and non-anastomotic strictures. RESULTS: 29% of 162 CD patients included developed an anastomotic stricture...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29134552/intranasal-delivery-of-%C3%AE-asarone-to-the-brain-with-lactoferrin-modified-mpeg-pla-nanoparticles-prepared-by-premix-membrane-emulsification
#13
Linmei Pan, Jing Zhou, Feng Ju, Huaxu Zhu
Alpha-asarone is a bioactive component of Acorus tatarincuii Schott with low bioavailability, which is often used for treatments of various brain diseases in clinical setting. This study was to formulate biodegradable methoxy polyethylene glycol-polylactic acid (mPEG-PLA) nanoparticles (NPs) surface-modified by lactoferrin (Lf), for delivering α-asarone into the brain following intranasal administration. Alpha-asarone NPs were prepared by premix membrane emulsification. The relative parameters were optimized by a Box-Behnken experimental design...
November 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29132828/lactoferrin-chitosan-and-melaleuca-alternifolia-natural-products-that-show-promise-in-candidiasis-treatment
#14
REVIEW
Lorena de Oliveira Felipe, Willer Ferreira da Silva Júnior, Katialaine Corrêa de Araújo, Daniela Leite Fabrino
The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited a high rate of resistance to antifungal drugs. Therefore, the objective of this review is to show that the use of natural products (extracts or isolated biomolecules), along with conventional antifungal therapy, can be a very promising strategy to overcome microbial multiresistance...
November 10, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29129647/salivary-biomarker-combination-prediction-model-for-the-diagnosis-of-periodontitis-in-a-taiwanese-population
#15
Yun-Chun Wu, Lee Ning, Yu-Kang Tu, Chen-Pang Huang, Nien-Tsu Huang, Yih-Fan Chen, Po-Chun Chang
BACKGROUND/PURPOSE: This study aimed at screening the diagnostic potential of salivary biomarkers and pairing them to establish a prediction model with higher accuracy in diagnosing periodontitis in the Taiwanese population. METHODS: Fifty-seven participants were divided into a non-periodontitis group and a periodontitis group. Salivary biomarkers CRP, IL-6, IL-8, IL-1β, IL-1ra, lactoferrin, MMP-8, MMP-9, PDGF-BB, TNF-α, and VEGF, were analyzed. The potential and reliability of the biomarkers for diagnosing periodontitis were analyzed dichotomously...
November 9, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29113893/saccharide-binding-by-intelectins
#16
Shailza Sharma, T N C Ramya
This communication probes ligand binding by human Intelectin-1 with several saccharides. Human Intelectin-1 was previously reported to bind to microbial glycans via ribofuranoside or galactofuranoside residues, whereas subsequently, a crystal structure of ligand bound hITLN1 indicated that hITLN1 does not bind to ribofuranoside but distinguishes between microbial and human glycans through a glycan motif - a terminal, acyclic 1,2-diol, which is present on galactofuranose and other microbial saccharides. Here, we demonstrate that besides glycerol and glycerol derivatives (which have an acyclic 1,2-diol), and 2-deoxy-d-galactose, d-ribose and 2-deoxy-d-ribose, which have been previously reported as human Intelectin-1 ligands, 2-C-hydroxymethyl-d-ribose, d-talose, d-idose, d-altrose and sorbitol also elute human Intelectin-1 from Sepharose CL-6B...
November 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29113196/inhibition-of-dmh-dss-induced-colorectal-cancer-by-liposomal-bovine-lactoferrin-in-rats
#17
Yuka Sugihara, Xiaoxu Zuo, Takashi Takata, Shengjian Jin, Mutumi Miyauti, Atusi Isikado, Hiromichi Imanaka, Masaaki Tatsuka, Guangying Qi, Fumio Shimamoto
Bovine lactoferrin (bLF) is a multifunctional protein with anti-inflammatory, antibacterial, antiviral, anti-tumour and immunoregulatory effects. The present study was conducted to evaluate the anti-inflammatory and anti-tumour effects of liposomal bLF (LbLF) in a 1,2-dimethylhydrazine (DMH)/dextran sulphate sodium (DSS)-induced model of carcinogenesis in F344 rats. F344 rats were randomly divided into three groups: Control (water), 500 or 1,000 mg/kg/day LbLF; additionally, the rats were injected with DMH (20 mg/kg) once per week for 8 consecutive weeks, after one week of drinking water containing 1% DSS...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112400/lactoferrin-exerts-anti-tumor-effects-by-inhibiting-angiogenesis-in-a-ht29-human-colon-tumor-model
#18
Huiying Li, Ming Li, Chaochao Luo, Jiaqi Wang, Nan Zheng
To investigate the effect and potential mechanisms of lactoferrin on colon cancer cells and tumors, HT29 and HCT8 cells were exposed to varying concentrations of lactoferrin, and the impact on cell proliferation, migration and invasion were observed. Cell proliferation test showed that high dosage of lactoferrin (5-100 mg/mL) inhibited cell viability in a dose-dependent manner, with the 50% concentration of inhibition at 81.3±16.7 mg/mL and 101±23.8 mg/mL for HT29 and HCT8 cells, respectively. Interestingly, migration and invasion of the cells were inhibited dramatically by 20 mg/mL lactoferrin, consistent with the significant down regulation of VEGFR2, VEGFA, pPI3K, pAkt and pErk1/2 proteins...
November 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29110675/lactoferrin-and-lysozyme-to-reduce-environmental-enteric-dysfunction-and-stunting-in-malawian-children-study-protocol-for-a-randomized-controlled-trial
#19
William D Cheng, Karl J Wold, Nicole S Benzoni, Chrissie Thakwalakwa, Kenneth M Maleta, Mark J Manary, Indi Trehan
BACKGROUND: Chronic childhood malnutrition, as manifested by stunted linear growth, remains a persistent barrier to optimal child growth and societal development. Environmental enteric dysfunction (EED) is a significant underlying factor in the causal pathway to stunting, delayed cognitive development, and ultimately morbidity and mortality. Effective therapies against EED and stunting are lacking and further clinical trials are warranted to effectively identify and operationalize interventions...
November 6, 2017: Trials
https://www.readbyqxmd.com/read/29103168/fusion-of-dna-binding-domain-of-pyrococcus-furiosus-ligase-with-taqstoffel-dna-polymerase-as-a-useful-tool-in-pcr-with-difficult-targets
#20
Marta Śpibida, Beata Krawczyk, Beata Zalewska-Piątek, Rafał Piątek, Magdalena Wysocka, Marcin Olszewski
The DNA coding sequence of TaqStoffel polymerase was fused with the DNA-binding domain of Pyrococcus furiosus ligase. The resulting novel recombinant gene was cloned and expressed in E. coli. The recombinant enzyme was purified and its enzymatic features were studied. The fusion protein (PfuDBDlig-TaqS) was found to have enhanced processivity as a result of the conversion of the TaqDNA polymerase from a relatively low processive to a highly processive enzyme. The abovementioned processivity enhancement was about threefold as compared to the recombinant TaqStoffel DNA polymerase (TaqS), and the recombinant fusion protein was more thermostable...
November 4, 2017: Applied Microbiology and Biotechnology
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