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Lactoferrin

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https://www.readbyqxmd.com/read/27917008/visualization-of-neutrophil-extracellular-traps-and-fibrin-meshwork-in-human-fibrinopurulent-inflammatory-lesions-iii-correlative-light-and-electron-microscopic-study
#1
Takanori Onouchi, Kazuya Shiogama, Yasuyoshi Mizutani, Takashi Takaki, Yutaka Tsutsumi
Neutrophil extracellular traps (NETs) released from dead neutrophils at the site of inflammation represent webs of neutrophilic DNA stretches dotted with granule-derived antimicrobial proteins, including lactoferrin, and play important roles in innate immunity against microbial infection. We have shown the coexistence of NETs and fibrin meshwork in varied fibrinopurulent inflammatory lesions at both light and electron microscopic levels. In the present study, correlative light and electron microscopy (CLEM) employing confocal laser scanning microscopy and scanning electron microscopy was performed to bridge light and electron microscopic images of NETs and fibrin fibrils in formalin-fixed, paraffin-embedded, autopsied lung sections of legionnaire's pneumonia...
November 1, 2016: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/27913645/iga-complexes-in-plasma-and-synovial-fluid-of-patients-with-rheumatoid-arthritis-induce-neutrophil-extracellular-traps-via-fc%C3%AE-ri
#2
Esil Aleyd, Marjon Al, Cornelis W Tuk, Conny J van der Laken, Marjolein van Egmond
Autoantibodies, including rheumatoid factor (RF), are an important characteristic of rheumatoid arthritis (RA). Interestingly, several studies reported a correlation between the presence of IgA autoantibodies and worse disease course. We demonstrated previously that triggering the IgA Fc receptor (FcαRI) on neutrophils results in neutrophil recruitment and the release of neutrophil extracellular traps (NETs). Because this can lead to tissue damage, we investigated whether IgA immune complexes in plasma and synovial fluid of RA patients activate neutrophils...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27912038/high-levels-of-chemokine-c-c-motif-ligand-20-in-human-milk-and-its-production-by-oral-keratinocytes
#3
Alan G Lourenço, Marilena C Komesu, Geraldo Duarte, Luiz A Del Ciampo, Marisa M Mussi-Pinhata, Aparecida Y Yamamoto
BACKGROUND: Chemokine C-C motif ligand 20 (CCL20) is implicated in the formation and function of mucosal lymphoid tissues. Although CCL20 is secreted by many normal human tissues, no studies have evaluated the presence of CCL20 in human milk or its production by oral keratinocytes stimulated by human milk. OBJECTIVE: To evaluate the presence of CCL20 in breast milk and verify CCL20 secretion in vitro by oral keratinocytes stimulated with human and bovine milk, as well as its possible association with breast milk lactoferrin levels...
December 2, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27910138/canine-and-feline-colostrum
#4
S Chastant-Maillard, C Aggouni, A Albaret, A Fournier, H Mila
Puppy and kitten survival over the first weeks is particularly dependent on colostrum, a specific secretion of the mammary gland produced during the first 2 days post-partum. Colostrum is a source of nutrients and immunoglobulins. It also contributes to the digestive tract maturation. Colostrum differentiates from milk mainly based on its concentration in immunoglobulins G: 20-30 g/L in dog colostrum, 40-50 g/L in cats' vs <1 g/L in milk. IgG concentration rapidly drops after parturition (-50% in 24 hr)...
November 30, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27903840/evaluation-of-antioxidant-intakes-in-relation-to-inflammatory-markers-expression-within-the-normal-breast-tissue-of-breast-cancer-patients
#5
Danielle Larouche, Mirette Hanna, Sue-Ling Chang, Simon Jacob, Bernard Têtu, Caroline Diorio
Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903408/correlations-between-ceruloplasmin-lactoferrin-and-myeloperoxidase-in-meconium
#6
Ewa Skarżyńska, Joanna Żytyńska-Daniluk, Barbara Lisowska-Myjak
BACKGROUND AND AIMS: Oxidative stress and the generation of reactive oxygen/nitrogen species has a known significant impact on intrauterine fetal growth and the risk of metabolic diseases in adulthood. Compounds accumulated in fetal meconium may be a source of information about the oxidoreductive status during the intrauterine development. Three metal-containing proteins ceruloplasmin (CP), lactoferrin (LF) and myeloperoxidase (MPO) constitute the complementary panel modulating oxidative stress...
November 23, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27902700/plasma-lactoferrin-levels-positively-correlate-with-insulin-resistance-despite-an-inverse-association-with-total-adiposity-in-lean-and-severely-obese-patients
#7
Sylvain Mayeur, Alain Veilleux, Yves Pouliot, Benoît Lamarche, Jean-François Beaulieu, Frédéric S Hould, Denis Richard, André Tchernof, Emile Levy
CONTEXT: Lactoferrin (Lf) is an important protein found on mucosal surfaces, within neutrophils and various cells, and in biological fluids. It displays multiple functions, including iron-binding as well as antimicrobial, immunomodulatory and anti-inflammatory activities. Although Lf ingestion has been suggested to cause adiposity reduction in murine models and humans, its relationship with insulin resistance (IR) has not been studied thoroughly. OBJECTIVE: To establish the association between circulating Lf levels, glucose status and blood lipid/lipoprotein profile...
2016: PloS One
https://www.readbyqxmd.com/read/27889801/production-and-purification-of-an-untagged-recombinant-pneumococcal-surface-protein-a-pspa4pro-with-high-purity-and-low-endotoxin-content
#8
Douglas B Figueiredo, Eneas Carvalho, Mauricio P Santos, Stefanie Kraschowetz, Rafaela T Zanardo, Gilson Campani, Gabriel G Silva, Cíntia R Sargo, Antonio Carlos L Horta, Roberto de C Giordano, Eliane N Miyaji, Teresa C Zangirolami, Joaquin Cabrera-Crespo, Viviane Maimoni Gonçalves
Streptococcus pneumoniae is the main cause of pneumonia, meningitis, and other conditions that kill thousands of children every year worldwide. The replacement of pneumococcal serotypes among the vaccinated population has evidenced the need for new vaccines with broader coverage and driven the research for protein-based vaccines. Pneumococcal surface protein A (PspA) protects S. pneumoniae from the bactericidal effect of human apolactoferrin and prevents complement deposition. Several studies indicate that PspA is a very promising target for novel vaccine formulations...
November 26, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27885724/identification-of-lactoferrin-and-glutamate-receptor-interacting-protein-1-in-bovine-cervical-mucus-a-putative-marker-for-oestrous-detection
#9
W Y Lee, M H Park, K W Kim, H Song, K B Kim, C S Lee, N K Kim, J K Park, B C Yang, K B Oh, G S Im, H J Chung
Accurate detection of oestrus is important for artificial insemination. The aim of this study was to identify oestrous-specific bovine cervical mucus proteins that could be used to determine the optimal time for artificial insemination. Non-oestrous and controlled internal drug release (CIDR)-induced oestrous-stage mucus proteins were purified and subjected to surface-enhanced laser desorption/ionization time-of-flight mass spectrometry, sodium dodecyl sulphate polyacrylamide gel electrophoresis and MALDI-TOF/TOF...
November 25, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27875949/treponema-iron-and-neurodegeneration
#10
A Jolivet-Gougeon, M Bonnaure Mallet
Spirochetes are suspected to be linked to the genesis of neurological diseases, including neurosyphillis or neurodegeneration (ND). Impaired iron homeostasis has been implicated in loss of function in several enzymes requiring iron as a cofactor, formation of toxic oxidative species, inflammation and elevated production of beta-amyloid proteins. This review proposes to discuss the link that may exist between the involvement of Treponema spp. in the genesis or worsening of ND, and iron dyshomeostasis. Proteins secreted by Treponema can act directly on iron metabolism, with hemin binding ability (HbpA and HbpB) and iron reductase able to reduce the central ferric iron of hemin, iron-containing proteins (rubredoxin, neelaredoxin, desulfoferrodoxin metalloproteins, bacterioferritins etc)...
November 21, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27872513/vaginal-lactoferrin-modulates-pge2-mmp-9-mmp-2-and-timp-1-amniotic-fluid-concentrations
#11
Alessandro Trentini, Martina Maritati, Carlo Cervellati, Maria C Manfrinato, Arianna Gonelli, Carlo A Volta, Fortunato Vesce, Pantaleo Greco, Franco Dallocchio, Tiziana Bellini, Carlo Contini
Inflammation plays an important role in pregnancy, and cytokine and matrix metalloproteases (MMPs) imbalance has been associated with premature rupture of membranes and increased risk of preterm delivery. Previous studies have demonstrated that lactoferrin (LF), an iron-binding protein with anti-inflammatory properties, is able to decrease amniotic fluid (AF) levels of IL-6. Therefore, we aimed to evaluate the effect of vaginal LF administration on amniotic fluid PGE2 level and MMP-TIMP system in women undergoing genetic amniocentesis...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27864056/lactoferrin-nanoparticle-mediated-targeted-delivery-of-5-fluorouracil-for-enhanced-therapeutic-efficacy
#12
Sonali Kumari, Anand K Kondapi
Malignant melanoma is an aggressive form of skin cancer with high mortality rates. Common treatments for malignant melanoma involve a combination of radiotherapy and chemotherapy with fluorouracil (5-FU). A major challenge with melanoma treatment is active resistance to chemotherapeutic drugs. Superior treatment outcome lies on balance involving optimum therapeutic doses and the side effects associated with dose escalation. The study aimed to efficiently entrap 5-FU in lactoferrin nanoparticles (LfNPs) in an attempt to enhance its therapeutic efficacy...
November 15, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27861481/-presence-of-lactoferrin-lf-in-lymphocutaneous-sporotrichosis-yeast-bound-antimicrobial-peptide
#13
Alejandro Palma-Ramos, Laura E Castrillón-Rivera, María Elisa Vega-Mémije, Roberto Arenas-Guzmán, Lucía Rangel-Gamboa
: Sporotrichosis is a common subcutaneous mycosis in Latin America, produced by dimorphic fungi belong to Sporothrix schenckii complex of cryptic species. Infection is acquired by traumatic inoculation with contaminated organic material. Host immune response includes polymorphonuclear neutrophils chemotaxis and release of granular components. Lactoferrin is a protein member of the transferrin family of iron-binding proteins, present inside polymorphonuclear granular structure, and has been reported to affect growth and development of infectious agents, including fungal organisms...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27860377/local-application-of-lactoferrin-promotes-bone-regeneration-in-a-rat-critical-sized-calvarial-defect-model-as-demonstrated-by-micro-ct-and-histological-analysis
#14
Ryan Gao, Maureen Watson, Karen E Callon, Donna Tuari, Michael S Dray, Dorit Naot, Satya Amirapu, Jacob T Munro, Jillian Cornish, David S Musson
Lactoferrin is a multifunctional glycoprotein with therapeutic potential for bone tissue engineering. The aim of this study was to assess the efficacy of local application of lactoferrin on bone regeneration. Five-millimetre critical-sized defects were created over the right parietal bone in 64 Sprague-Dawley rats. The rats were randomized into four groups: group 1 (n = 20) had empty defects; group 2 (n = 20) had defects grafted with collagen gels (3 mg/mL); group 3 (n = 20) had defects grafted with collagen gels impregnated with bovine lactoferrin (10 µg/gel) and group 4 (n = 4) had sham surgeries (skin and periosteal incisions only)...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27845023/antimicrobial-activity-of-buttermilk-and-lactoferrin-peptide-extracts-on-poultry-pathogens
#15
Catherine Jean, Martine Boulianne, Michel Britten, Gilles Robitaille
Antibiotics are commonly used in poultry feed as growth promoters. This practice is questioned given the arising importance of antibiotic resistance. Antimicrobial peptides can be used as food additives for a potent alternative to synthetic or semi-synthetic antibiotics. The objective of this study was to develop a peptide production method based on membrane adsorption chromatography in order to produce extracts with antimicrobial activity against avian pathogens (Salmonella enterica var. Enteritidis, Salmonella enterica var...
November 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27834141/in-vitro-exploration-of-the-anti-hcv-potential-of-the-synthetic-spacer-peptides-derived-from-human-bovine-and-camel-lactoferrins
#16
Abdulgader H Albar, Esmail M El-Fakharany, Hussein A Almehdar, Vladimir N Uversky, Elrashdy M Redwan
Chronic liver disease is often associated with the infection by hepatitis C virus (HCV), which is an enveloped RNA virus belonging to the Flaviviridae family. Many studies found that milk proteins, such as lactoferrin, might have profound antiviral activity against HCV. Various secretory fluids ranging from milk, to tears, saliva, and nasal secretion, and to bile and pancreatic juice, as well as neutrophils, mucosal surfaces, and blood contain a widely spread multifunctional glycoprotein, lactoferrin (Lf), structure of which can be depicted as two homologous domains connected by the short spacer peptide...
November 11, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27833152/selenium-binding-lactoferrin-is-taken-into-corneal-epithelial-cells-by-a-receptor-and-prevents-corneal-damage-in-dry-eye-model-animals
#17
Akihiro Higuchi, Hiroyoshi Inoue, Yoshio Kaneko, Erina Oonishi, Kazuo Tsubota
The ocular surface is strongly affected by oxidative stress, which causes many ocular diseases including dry eye. Previously, we showed that selenium compounds, e.g., selenoprotein P and Se-lactoferrin, were candidates for treatment of dry eye. This paper shows the efficacy of Se-lactoferrin for the treatment of dry eye compared with Diquas as a control drug using two dry eye models and incorporation of lactoferrin into corneal epithelial cells via lactoferrin receptors. We show the efficacy of Se-lactoferrin eye drops in the tobacco smoke exposure rat dry eye model and short-term rabbit dry eye model, although Diquas eye drops were only effective in the short-term rabbit dry eye model...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27832504/effects-of-lactoferrin-derived-peptides-on-simulants-of-biological-warfare-agents
#18
Tjitske Sijbrandij, Antoon J Ligtenberg, Kamran Nazmi, Enno C I Veerman, Jan G M Bolscher, Floris J Bikker
Lactoferrin (LF) is an important immune protein in neutrophils and secretory fluids of mammals. Bovine LF (bLF) harbours two antimicrobial stretches, lactoferricin and lactoferampin, situated in close proximity in the N1 domain. To mimic these antimicrobial domain parts a chimeric peptide (LFchimera) has been constructed comprising parts of both stretches (LFcin17-30 and LFampin265-284). To investigate the potency of this construct to combat a set of Gram positive and Gram negative bacteria which are regarded as simulants for biological warfare agents, the effect on bacterial killing, membrane permeability and membrane polarity were determined in comparison to the constituent peptides and the native bLF...
January 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27829421/bovine-lactoferrin-free-of-lipopolysaccharide-can-induce-a-proinflammatory-response-of-macrophages
#19
Nada Zemankova, Katarina Chlebova, Jan Matiasovic, Jana Prodelalova, Jan Gebauer, Martin Faldyna
BACKGROUND: Lactoferrin (LF) is an 80 kDa glycoprotein which is known for its effects against bacteria, viruses and other pathogens. It also has a high potential in nutrition therapy and welfare of people and a variety of animals, including piglets. The ability to bind lipopolysaccharide (LPS) is one of the described anti-inflammatory mechanisms of LF. Previous studies suggested that cells can be stimulated even by LPS-free LF. Therefore, the aim of our study was to bring additional information about this possibility...
November 10, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27825391/oestrous-cycle-dependent-equine-uterine-immune-response-to-induced-infectious-endometritis
#20
Christina D Marth, Simon M Firestone, Lisa Y Glenton, Glenn F Browning, Neil D Young, Natali Krekeler
Infectious endometritis is a major cause of reduced pregnancy rates in horses. The objectives of this study were to establish a timeline of the innate immune response in the uterus of healthy horses and to investigate the oestrous cycle effect on this. Endometrial biopsies were collected from five horses before and at 3, 12, 24, 48 and 72 h after inoculation of Escherichia coli, once in oestrus and once in dioestrus. They were analysed by quantitative real-time PCR, microbiology and histology. Neutrophil numbers increased from very low levels in the absence of inflammation to severe neutrophilia 3 h after inoculation...
November 8, 2016: Veterinary Research
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