keyword
MENU ▼
Read by QxMD icon Read
search

Role model

keyword
https://www.readbyqxmd.com/read/29169219/genome-analysis-of-the-naphthalene-degrading-pseudomonas-sp-as1-harboring-the-megaplasmid-pas1
#1
Jisun Kim, Woojun Park
Polycyclic aromatic hydrocarbons (PAHs), including naphthalene, are widely distributed in nature. Naphthalene has been regarded as a model PAH compound for investigating the mechanisms of bacterial PAH biodegradation. Pseudomonas sp. AS1 isolated from an arsenic-contaminated site is capable of growing on various aromatic compounds such as naphthalene, salicylate, and catechol, but not on gentisate. The genome of strain AS1 consists of a 6,126,864 bp circular chromosome and the 81,841 bp circular plasmid pAS1...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29169198/-changes-in-sense-of-coherence-mental-distress-and-satisfaction-with-life-and-studies-in-the-course-of-psychosocial-counselling
#2
Asimina Koutsoukou-Argyraki, Alina Bertolino, Volker Kreß, Frank-Hagen Hofmann, Michael Sperth, Rainer Matthias Holm-Hadulla
"Sense of coherence" (SOC) plays an essential role in the maintenance or recovery of health, according to the salutogenetic approach of Aaron Antonovsky. Empirical studies provide evidence of significant links between sense of coherence and different indicators of mental health. In the present study, the effectivity of an integrative counselling concept for the promotion of sense of coherence, reduction of mental distress and improvement of satisfaction with life was tested in a sample of 153 clients and patients...
November 23, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29169114/evaluation-of-antiparkinson-activity-of-ptupb-by-measuring-dopamine-and-its-metabolites-in-drosophila-melanogaster-lc-ms-ms-method-development
#3
Navya Lakkappa, Praveen T Krishnamurthy, Karthik Yamjala, Sung Hee Hwang, Bruce D Hammock, B Babu
Soluble epoxide hydrolase (sEH) inhibition is reported to elevate endogenous epoxyeicosatrienoic acids (EET's), which are known to play an important role in neuroprotection by inhibiting oxidative stress and neuroinflammation. In the present study, PTUPB, a dual inhibitor of sEH and COX-2, has been tested for its antiparkinson activity against rotenone (ROT) induced neurodegeneration in Drosophila model of Parkinson's disease (PD). To determine the efficacy and brain bioavailability of PTUPB a simple, rapid and sensitive LC-MS/MS method was developed and validated for the estimation of PTUPB (Method-I), dopamine (DA) and its metabolites (Method-II) in fly head...
November 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169109/mechanism-and-efficiency-of-contaminant-reduction-by-hydrated-electron-in-the-sulfite-iodide-uv-process
#4
Keer Yu, Xuchun Li, Liwei Chen, Jingyun Fang, Huali Chen, Qiangbiao Li, Nianping Chi, Jun Ma
Advanced reduction by the extremely strong reducing species, hydrated electron (eaq(-)), is a promising and viable approach to eliminate a wide variety of persistent and toxic contaminants. In this study, we proposed a sulfite/iodide/UV process, which offered efficient production of eaq(-) for contaminant reduction. Using monochloroacetic acid (MCAA) as a simple eaq(-) probe, the availability of eaq(-) was assessed, and the mechanism involving the roles of S(IV) and iodide in the process was elucidated. A pronounced synergistic effect of S(IV) and iodide was observed in MCAA reductive dechlorination...
November 15, 2017: Water Research
https://www.readbyqxmd.com/read/29169086/linking-dynamic-patterns-of-neural-activity-in-orbitofrontal-cortex-with-decision-making
#5
REVIEW
Erin L Rich, Frederic M Stoll, Peter H Rudebeck
Humans and animals demonstrate extraordinary flexibility in choice behavior, particularly when deciding based on subjective preferences. We evaluate options on different scales, deliberate, and often change our minds. Little is known about the neural mechanisms that underlie these dynamic aspects of decision-making, although neural activity in orbitofrontal cortex (OFC) likely plays a central role. Recent evidence from studies in macaques shows that attention modulates value responses in OFC, and that ensembles of OFC neurons dynamically signal different options during choices...
November 20, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29169069/anti-inflammatory-agents-in-peripheral-arterial-disease
#6
REVIEW
Alexios S Antonopoulos, Evi Papanikolaou, Georgia Vogiatzi, Evangelos Oikonomou, Dimitris Tousoulis
Inflammation is pivotally involved in coronary and peripheral atherosclerotic disease. This established concept is based on both experimental animal models of vascular inflammation and Mendelian randomization studies demonstrating a causal relationship between pro-inflammatory cytokines (e.g. interleukin-6) and cardiovascular disease risk. More recently, the reduction of cardiovascular events by use of an interleukin-1β inhibitor (canakinumab) has revived interest in the use of anti-inflammatory agents for the treatment of atherosclerotic disease, including peripheral arterial disease...
November 20, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29169026/structures-and-mechanisms-in-clay-nanopore-trapping-of-structurally-different-fluoroquinolone-antimicrobials
#7
Fanny E K Okaikue-Woodi, Sabrina E Kelch, Michael P Schmidt, Carmen Enid Martinez, Randall E Youngman, Ludmilla Aristilde
Smectite clay nanoparticles are implicated in the retention of antimicrobials within soils and sediments; these clays are also inspected as drug carriers in physiological systems. Cation exchange is considered the primary adsorption mechanism of antimicrobials within smectite nanopores. However, a dual role of acid-base chemistry and adsorptive structures is speculated by recent studies. Using the prototypical smectite clay montmorillonite, we employed a combination of X-ray diffraction (XRD), nuclear magnetic resonance, attenuated total reflectance-Fourier transform infrared spectroscopy, and molecular dynamics simulations to investigate the interlayer nanopore trapping of two structurally-different fluoroquinolone (FQ) antimicrobials with similar acid-base chemistry: ciprofloxacin (a first-generation FQ) and moxifloxacin (a third-generation FQ)...
November 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29168945/analysis-of-the-experiences-of-nurses-who-return-to-nursing-after-cancer
#8
Karen-Leigh Edward, Jo-Ann Giandinoto, Judelle McFarland
BACKGROUND: understanding the impact of role ambiguity (both professional and patient) can be a factor in deepening the understanding of the ongoing personal, professional and organisational requirements of nurses who are cancer survivors. PURPOSE: the aim of this qualitative study was to elucidate an in-depth description of nurses' experiences of surviving cancer. METHOD: an exploratory qualitative research design was used (n=8), with participants recruited between September 2014 and December 2016...
November 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29168897/early-socioeconomic-conditions-and-severe-tooth-loss-in-middle-aged-costa-ricans
#9
Romain Fantin, Cyrille Delpierre, Michelle Kelly-Irving, Cristina Barboza Solís
OBJECTIVE: A wide literature shows a strong social gradient in tooth loss according to income, education and occupation, in both developed and developing countries. It has been shown associations between tooth loss and parental education and occupation, independently of adult conditions. To explore the role of early socioeconomic circumstances on tooth loss, we used a lifecourse model. We analysed the direct and indirect links between early socioeconomic conditions and severe adult tooth loss...
November 23, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29168882/fibroblast-growth-factor-2-regulates-activity-and-gene-expression-of-human-postmitotic-excitatory-neurons
#10
Shweta Gupta, Tanya M-Redmond, Fan Meng, Andrew Tidball, Huda Akil, Stanley Watson, Jack M Parent, Michael Uhler
Many neuropsychiatric disorders are thought to result from subtle changes in neural circuit formation. We used human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) to model mature, postmitotic excitatory neurons and examine effects of FGF2. FGF2 gene expression is known to be altered in brain regions of major depressive disorder (MDD) patients and FGF2 has anti-depressive effects in animal models of depression. We generated stable inducible neurons (siNeurons) conditionally expressing human neurogenin 2 (NEUROG2) to generate a homogenous population of post-mitotic excitatory neurons and study the functional as well as the transcriptional effects of FGF2...
November 23, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29168797/role-of-vitamin-e-in-the-treatment-of-alzheimer-s-disease-evidence-from-animal-models
#11
REVIEW
Agnese Gugliandolo, Placido Bramanti, Emanuela Mazzon
Alzheimer's disease (AD) is a neurodegenerative disorder representing the major cause of dementia. It is characterized by memory loss, and cognitive and behavioral decline. In particular, the hallmarks of the pathology are amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), formed by aggregated hyperphosphorylated tau protein. Oxidative stress plays a main role in AD, and it is involved in initiation and progression of AD. It is well known that Aβ induced oxidative stress, promoting reactive oxygen species (ROS) production and consequently lipid peroxidation, protein oxidation, tau hyperphosphorylation, results in toxic effects on synapses and neurons...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168762/dual-roles-of-fer-kinase-are-required-for-proper-hematopoiesis-and-vascular-endothelium-organization-during-zebrafish-development
#12
Emily M Dunn, Elizabeth J Billquist, Amy L VanderStoep, Phillip G Bax, Laura M Westrate, Lisa K McLellan, Shelby C Peterson, Jeffrey P MacKeigan, Aaron P Putzke
Fer kinase, a protein involved in the regulation of cell-cell adhesion and proliferation, has been shown to be required during invertebrate development and has been implicated in leukemia, gastric cancer, and liver cancer. However, in vivo roles for Fer during vertebrate development have remained elusive. In this study, we bridge the gap between the invertebrate and vertebrate realms by showing that Fer kinase is required during zebrafish embryogenesis for normal hematopoiesis and vascular organization with distinct kinase dependent and independent functions...
November 23, 2017: Biology
https://www.readbyqxmd.com/read/29168731/factors-influencing-the-phenotypic-characterization-of-the-oral-marker-prop
#13
REVIEW
Beverly J Tepper, Melania Melis, Yvonne Koelliker, Paolo Gasparini, Karen L Ahijevych, Iole Tomassini Barbarossa
In the last several decades, the genetic ability to taste the bitter compound, 6-n-propyltiouracil (PROP) has attracted considerable attention as a model for understanding individual differences in taste perception, and as an oral marker for food preferences and eating behavior that ultimately impacts nutritional status and health. However, some studies do not support this role. This review describes common factors that can influence the characterization of this phenotype including: (1) changes in taste sensitivity with increasing age; (2) gender differences in taste perception; and (3) effects of smoking and obesity...
November 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29168693/zfp281-is-essential-for-mouse-epiblast-maturation-through-transcriptional-and-epigenetic-control-of-nodal-signaling
#14
Xin Huang, Sophie Balmer, Fan Yang, Miguel Fidalgo, Dan Li, Diana Guallar, Anna-Katerina Hadjantonakis, Jianlong Wang
Pluripotency is defined by a cell's potential to differentiate into any somatic cell type. How pluripotency is transited during implantation, followed by lineage specification and establishment of the basic body plan is poorly understood. Here we report the transcription factor Zfp281 functions in the exit from naive pluripotency occurring coincident with pre-to-post-implantation mouse embryonic development. By characterizing Zfp281 mutant phenotypes and identifying Zfp281 gene targets and protein partners in developing embryos and cultured pluripotent stem cells, we establish critical roles for Zfp281 in activating components of the Nodal signaling pathway and lineage-specific genes...
November 23, 2017: ELife
https://www.readbyqxmd.com/read/29168662/how-social-stigma-sustains-the-hiv-treatment-gap-for-msm-in-mpumalanga-south-africa
#15
Kabelo Maleke, Joseph Daniels, Tim Lane, Helen Struthers, James McIntyre, Thomas Coates
There are gaps in HIV care for men who have sex with men (MSM) in African settings, and HIV social stigma plays a significant role in sustaining these gaps. We conducted a three-year research project with 49 HIV-positive MSM in two districts in Mpumalanga Province, South Africa, to understand the factors that inform HIV care seeking behaviors. Semi-structured focus group discussions and interviews were conducted in IsiZulu, SiSwati, and some code-switching into English, and these were audio-recorded, transcribed, and translated into English...
November 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/29168636/a-synthetic-isoprenoid-lipoquinone-menaquinone-2-adopts-a-folded-conformation-in-solution-and-at-a-model-membrane-interface
#16
Jordan T Koehn, Estela S Magallanes, Benjamin J Peters, Cheryle N Beuning, Allison A Haase, Michelle J Zhu, Christopher D Rithner, Dean C Crick, Debbie C Crans
Menaquinones (naphthoquinones, MK) are isoprenoids that play key roles in the respiratory electron transport system of some prokaryotes by shuttling electrons between membrane-bound protein complexes acting as electron acceptors and donors. Menaquinone-2 (MK-2), a truncated MK, was synthesized and the studies presented herein characterize the conformational and chemical properties of the hydrophobic MK-2 molecule. Using 2D NMR spectroscopy, we established for the first time that MK-2 has a folded conformation defined by the isoprenyl side-chain folding back over the napthoquinone in a U-shape, which depends on the specific environmental conditions found in different solvents...
November 23, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29168580/resveratrol-pterostilbene-and-dementia
#17
REVIEW
Klaus W Lange, Shiming Li
Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti-inflammatory, and antiamyloid effects. Resveratrol and its derivative pterostilbene are able to cross the blood-brain barrier and to influence brain activity. The present short review summarizes the available evidence regarding the effects of these polyphenols on pathology and cognition in animal models and human subjects with dementia. Numerous investigations in cellular and mammalian models have associated resveratrol and pterostilbene with protection against dementia syndromes such as Alzheimer's disease (AD) and vascular dementia...
November 23, 2017: BioFactors
https://www.readbyqxmd.com/read/29168546/glucocorticoids-and-beta-cell-function
#18
Marta Fichna, Piotr Fichna
Glucocorticoids (GCs) play a pivotal role in carbohydrate metabolism. They counteract insulin by decreasing peripheral glucose uptake and stimulating hepatic gluconeogenesis, although they are best known for inducing insulin resistance (IR). Moreover, GCs may attenuate the incretin effect. Nevertheless, their direct impact on beta cells is not fully defined. This review aims to present the current understanding of this subject. Humans exposed to GC excess display IR, impaired glucose tolerance, and eventually develop diabetes...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29168506/nfs1-undergoes-positive-selection-in-lung-tumours-and-protects-cells-from-ferroptosis
#19
Samantha W Alvarez, Vladislav O Sviderskiy, Erdem M Terzi, Thales Papagiannakopoulos, Andre L Moreira, Sylvia Adams, David M Sabatini, Kıvanç Birsoy, Richard Possemato
Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and in vivo tumours. Above the 3-8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1. Mammary or subcutaneous tumours grow despite suppression of NFS1, whereas metastatic or primary lung tumours do not...
November 22, 2017: Nature
https://www.readbyqxmd.com/read/29168482/uv-light-driven-prebiotic-synthesis-of-iron-sulfur-clusters
#20
Claudia Bonfio, Luca Valer, Simone Scintilla, Sachin Shah, David J Evans, Lin Jin, Jack W Szostak, Dimitar D Sasselov, John D Sutherland, Sheref S Mansy
Iron-sulfur clusters are ancient cofactors that play a fundamental role in metabolism and may have impacted the prebiotic chemistry that led to life. However, it is unclear whether iron-sulfur clusters could have been synthesized on prebiotic Earth. Dissolved iron on early Earth was predominantly in the reduced ferrous state, but ferrous ions alone cannot form polynuclear iron-sulfur clusters. Similarly, free sulfide may not have been readily available. Here we show that UV light drives the synthesis of [2Fe-2S] and [4Fe-4S] clusters through the photooxidation of ferrous ions and the photolysis of organic thiols...
December 2017: Nature Chemistry
keyword
keyword
20001
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"