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https://www.readbyqxmd.com/read/28650313/molecular-mechanisms-and-epidemiology-of-resistance-in-streptococcus-pneumoniae-in-the-middle-east-region
#1
Grace El Moujaber, Marwan Osman, Rayane Rafei, Fouad Dabboussi, Monzer Hamze
PURPOSE: Streptococcus pneumoniae is a commensal bacterium that normally colonizes the human nasopharyngeal cavity. Once disseminated, it can cause several diseases, ranging from non-invasive infections such as acute otitis media and sinusitis through to invasive infections with higher mortality, including meningitis and septicaemia. Since the identification of the first S. pneumoniae strain with decreased susceptibility to penicillin in the 1960s, antibiotic resistance among S. pneumoniae has increased disturbingly and the mechanisms of resistance have begun to unfold...
June 26, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28650250/a-retrospective-longitudinal-claims-based-comparison-of-concomitant-diagnoses-between-individuals-with-and-without-down-syndrome
#2
Amanda M Kong, Dana Hurley, Kristin A Evans, Diana Brixner, Csilla Csoboth, Jeannie Visootsak
BACKGROUND: Individuals with Down syndrome (DS) experience various comorbidities in excess of the prevalence seen among the non-DS population. However, the extent of the excess burden of comorbidities specifically within commercially and publicly insured DS populations aged < 21 years is not currently known. OBJECTIVES: To (a) describe the most common diagnoses among individuals with DS who have either commercial or Medicaid insurance and (b) compare the prevalence of those diagnoses between DS cases and non-DS controls...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28649508/isolation-of-shewanella-putrefaciens-in-an-elderly-man-with-subacute-intestinal-obstruction-appendicitis
#3
Arif Maqsood Ali, Muhammad Noorulamin, Shazia Arif
Shewanella is Gram-negative motile bacillus, non fermentative and facultative anaerobe. Its natural habitat is all forms of water and soil, but has also been isolated from fish, dairy products, oils, and carcasses. Often found with microflora of the marine environment. Bacterial infections with Shewanella spp. are rare. The exposure to the marine environment, sea and diary food are considered as a risk factor for Shewanella spp. infection. Clinical infections seen are otitis, soft tissue infection, bacteremia, ear infection, eye infection, infective arthritis, osteomyelitis, infective endocarditis and peritonitis...
2017: IDCases
https://www.readbyqxmd.com/read/28648390/clinical-and-microbiological-characteristics-of-unusual-manifestations-of-invasive-pneumococcal-disease
#4
Adrian Sousa, Maria Teresa Pérez-Rodríguez, Andrés Nodar, Lucía Martínez-Lamas, Francisco Jose Vasallo, Maximiliano Álvarez-Fernández, Manuel Crespo
INTRODUCTION: Invasive pneumococcal disease (IPD) typically presents as bacterial pneumonia, meningitis or primary bacteraemia. However, Streptococcus pneumoniae can produce infection at any level of the body (endocarditis, arthritis, spontaneous bacterial peritonitis, etc.), which is also known as unusual IPD (uIPD). There are very limited data available about the clinical and microbiological profile of these uncommon manifestations of pneumococcal disease. Our aim was to analyse clinical forms, microbiological profile, epidemiology and prognosis of a cohort of patients with unusual invasive pneumococcal disease (uIPD)...
June 22, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28645923/the-connection-between-acute-otitis-media-and-the-acute-abdomen
#5
Imran Masood, Tami Hendriksz
A female aged 9 years with a recent episode of acute otitis media (AOM) presented to her primary care physician with complaints of severe abdominal pain with right lower quadrant rebound tenderness, suggestive of an acute surgical abdomen. Neurological examination was normal on presentation. She was transferred to the local children's hospital for workup of appendicitis, during which she began exhibiting ataxia and slurred speech. Further evaluation revealed mastoiditis, venous sinus thrombosis and subdural empyema...
June 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28637148/pure-tone-hearing-profiles-in-children-with-otitis-media-with-effusion
#6
Ting Cai, Bradley McPherson, Caiwei Li, Feng Yang
INTRODUCTION: Otitis media with effusion (OME) is a common middle ear disease in children. The associated conductive hearing loss is a major concern for hearing health professionals. The aim of the present study was to describe the configuration of pure tone audiograms of children with OME and to design a statistical stratification algorithm to facilitate hearing loss profiling in children with OME. METHODS: School age children with OME were recruited. Bone and air conduction thresholds were obtained using standard procedures...
February 25, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28636202/squamous-cell-carcinoma-of-the-temporal-bone-in-30-patients-difference-in-presentation-and-treatment-of-post-irradiation-and-de-novo-disease
#7
Ho Yee Sun, Raymond K Tsang
Squamous cell carcinoma temporal bone (SCCTB) is a rare malignancy with incidence of around 1 to 1.2 case per million populations per year. Risk factors included chronic otitis media and chronic irritation of the skin and mucosa of the external and middle ear. A rare but important aetoloigy is radiation to the region for treatment of head and neck malignancies. This article is protected by copyright. All rights reserved.
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28631687/-acquired-atresia-and-stenosis-of-the-external-acoustic-meatus
#8
D S Kondratchikov, Kh M Diab, V S Korvyakov, L I Terekhina
Acquired atresia of the external acoustic meatus is a rare pathological condition characterized by obliteration of the medial part of the external acoustic canal by a soft fibrous plug. The present article presents an overview of a series of cases of acquired atresia and stenosis of the external acoustic meatus with the description of etiology, pathogenesis, and methods for the treatment of this condition. In the majority of the cases, atresia develops at the final stage of granulation external otitis with or without an accompanying dermatological pathology...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28631681/-the-evaluation-of-the-quality-of-life-in-a-healthy-population-with-the-use-of-the-comq-12-questionnaire
#9
S Ya Kosyakov, Yu V Minavnina, K N Bgantseva, A L Dryupin
The COMQ-12 questionnaire has been elaborated to evaluate the deterioration in the quality of life of the subjects suffering from chronic suppurative otitis media (CSOM) based on the reports of the patients themselves. This questionnaire is of special interest in that it allows to register the complaints of the patients stated by them in the order of priority beginning from those that are responsible for the most pronounced manifestations of the impairment in the quality of life. It, in turn, helps the medical practitioner to rationally organize the treatment of a concrete patient taking into consideration his or her individual expectations...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28631672/-the-influence-of-interleukin-gene-polymorphism-on-the-serum-cytokine-level-in-the-patients-presenting-with-chonic-suppurative-otitis-media
#10
E V Baike, Yu A Vitkovsky, A A Dutova
The objective of the present work was to study the influence of allelic variant associations of 1-beta interleukin (C3953T, &511C, T31C), interleukin-6 (C174G), and tumour necrosis factor-alpha (G308A) gene polymorphisms on the serum cytokine level in the patients presenting with chronic suppurative otitis media. A total of 299 patients at the age varying from 16 to 55 years with this condition divided into three groups were examined. Group 1 was comprised of 146 patients suffering from the tubotympanic form of chronic suppurative otitis media (CSOM)...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28631671/-the-anatomical-features-of-the-middle-ear-exerting-the-influence-on-the-formation-of-exudative-otitis-media-in-the-breast-fed-infants-of-different-gestational-age
#11
A G Matroskin, I V Rakhmanova, A A Dreval', A N Kislyakov, A I Vladimirov
The objective of the present study was to elucidate the anatomical features of the structure of the middle ear and eustachian tube in the breast-fed infants of different gestational age that may be responsible for the formation of exudates (fluids). We have examined 150 temporal bones obtained from the children's cadavers that were allocated to three groups as follows: 50 temporal bones obtained at weeks 26-30 weeks of gestation (group 1), 44 bones 31-36 weeks of gestation (group 2), and 37-40 weeks of gestation (full-term babies, group 3),The analysis of the data obtained on an individual bases revealed either increase or decreases in the selected characteristics of the eustachian tube in comparison with the respective average values as well as the well apparent predominance of a single change or a combination of alteration of several parameters in one case in 26-30 weeks and 31-36 weeks groups...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28628951/cranial-indicators-identified-for-peak-incidence-of-otitis-media
#12
Anthony Pagano, Eugene Wang, Derek Yuan, Daniel Fischer, Charles Bluestone, Samuel Marquez, Jeffrey Laitman
Acute otitis media (AOM) is one of the most common pediatric conditions worldwide. Peak age of occurrence for AOM has been identified within the first postnatal year and it remains frequent until approximately six postnatal years. Morphological differences between adults and infants in the cartilaginous Eustachian tube (CET) and associated structures may be responsible for development of this disease yet few have investigated normal growth trajectories. We tested hypotheses on coincidence of skeletal growth changes and known ages of peak AOM occurrence...
June 19, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28625810/evaluating-the-ototoxicity-of-a-anti-mrsa-peptide-kr-12-a2
#13
Chung Man Sung, Hong Chan Kim, Yong Beom Cho, Song Yub Shin, Chul Ho Jang
INTRODUCTION: Methicillin-Resistant Staphylococcus aureus (MRSA) is an emerging problem for the treatment of chronic suppurative otitis media, and also for pediatric tympanostomy tube otorrhea. To date, there are no effective topical antibiotic drugs to treat MRSA otorrhea. OBJECTIVE: In this study, we evaluated the ototoxicity of topical KR-12-a2 solution on the cochlea when it applied topically in the middle ear of guinea pigs. METHODS: The antimicrobial activity of KR-12-a2 against MRSA strains was examined by using the inhibition zone test...
May 31, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28616365/streptococcus-pneumoniae-otitis-media-pathogenesis-and-how-it-informs-our-understanding-of-vaccine-strategies
#14
REVIEW
Caroline Bergenfelz, Anders P Hakansson
PURPOSE OF REVIEW: This study aimed to review the literature regarding the mechanisms of transition from asymptomatic colonization to induction of otitis media and how the insight into the pathogenesis of otitis media has the potential to help design future otitis media-directed vaccines. RECENT FINDINGS: Respiratory viruses have long been shown to predispose individuals to bacterial respiratory infections, such as otitis media. Recent information suggests that Streptococcus pneumoniae, which colonize the nasopharynx asymptomatically, can sense potentially "threatening" changes in the nasopharyngeal environment caused by virus infection by upregulating specific sets of genes involved in biofilm release, dissemination from the nasopharynx to other sites, and protection against the host immune system...
2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/28616364/recurrent-acute-otitis-media-what-are-the-options-for-treatment-and-prevention
#15
REVIEW
Anna Granath
PURPOSE OF REVIEW: To survey current strategies for treatment and prevention of recurrent acute otitis media (rAOM). RECENT FINDINGS: Treatment with systemic antibiotics is required in recurrent episodes of acute otitis media. A cautious attitude is recommended due to antibiotic resistance. Antibiotics also provide effective prophylaxis for rAOM. Topical treatment with ear drops is recommended in rAOM with otorrhea from tympanostomy tubes. Pneumococcal conjugated vaccines seem to have a moderate reductive effect on overall otitis media...
2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/28615125/effect-of-mycoplasma-bovis-on-bovine-neutrophils
#16
Steve Jimbo, Muhammad Suleman, Teresia Maina, Tracy Prysliak, Musa Mulongo, Jose Perez-Casal
Mycoplasma bovis (M. bovis) is a small bacterium that lacks a cell wall. M. bovis infection results in chronic pneumonia and polyarthritis syndrome (CPPS), otitis media, conjunctivitis, and meningitis in feedlot cattle and mastitis in dairy cattle. Numerous studies of peripheral mononuclear cells (PBMC) indicate that M. bovis evades host immunity through targeted effects on immune cell activity, including inhibition of effector function and simultaneous aberrant activation of immune cell activity that has no effect on protection against the bacterium...
June 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28611633/hematogenous-renal-cell-carcinoma-metastasis-in-the-postoperative-temporal-bone
#17
Masaya Konishi, Kensuke Suzuki, Hiroshi Iwai
Metastatic renal cell carcinoma (RCC) involving the temporal bone is a rare entity. It is usually asymptomatic and misdiagnosis as acute otitis media, mastoiditis, and Ramsay-Hunt syndrome in early onset is not uncommon. We report a case of RCC metastasis to the postoperative temporal bone in the middle of molecular targeted therapy. A 60-year-old man presented left facial palsy with severe retro-auricular pain and he also underwent left middle ear surgery for cholesteatoma more than 30 years before and had been aware of discontinuous otorrhea; therefore, initially we speculated that facial palsy was derived from recurrent cholesteatoma or Ramsay-Hunt syndrome...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28608739/safety-of-repeated-dose-intratympanic-injections-with-am-101-in-acute-inner-ear-tinnitus
#18
Hinrich Staecker, Michael Morelock, Timothy Kramer, Pavel Chrbolka, Joong Ho Ahn, Thomas Meyer
Objective To evaluate the safety and tolerability of repeated intratympanic administration of the gel-formulated NMDA receptor antagonist AM-101 in acute patients with inner ear tinnitus. Study Design Prospective, double-blind, randomized, placebo-controlled study. Setting Sixty-nine secondary and tertiary sites in North America, Europe, and Asia. Subjects and Methods In total, 343 subjects with persistent acute tinnitus after traumatic cochlear injury or otitis media were randomized to receive 3 intratympanic doses of either AM-101 0...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28607891/cholesteatoma-induced-labyrinthine-fistula-is-aggressiveness-in-removing-disease-justified
#19
Prem Sagar, K Devaraja, Rajeev Kumar, Sumanth Bolu, Suresh C Sharma
Issues of complete disease clearance and hearing preservation in cholesteatoma induced labyrinthine fistula cases has been discussed and updated in this article. Successful disease clearance and hearing preservation in a case of cholesteatoma induced isolated cochlear promontory fistula encouraged us to retrospectively analyse 13 more cases of cholesteatoma induced labyrinthine fistula who presented in emergency service as complicated chronic suppurtive otitis media. Pre-operatively nine patients experienced vertigo, two had profound sensori neural hearing loss and radiology was suggestive of labyrinthine fistula in 12 patients...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28607885/comparative-evaluation-of-tympanoplasty-with-or-without-mastoidectomy-in-treatment-of-chronic-suppurative-otitis-media-tubotympanic-type
#20
Anjana Agrawal, Puneet Bhargava
To study the role of tympanoplasty alone and tympanoplasty done along with cortical mastoidectomy in CSOM in term of graft uptake, improvement of hearing and removal of disease. This is retrospective study of patient at tertiary referral centre, conducted in between October 2015 and October 2016, study was done on 40 patients of either sex in the age group 20-50 years. Tympanoplasty alone was done in 20 cases and tympanoplasty along with cortical mastoidectomy was done in rest 20 cases. Patient were reviewed post operatively on 2, 4, 8 and 16 weeks to inspect post operative graft uptake and PTA was done at fourth month to evaluate hearing improvement...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
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