keyword
MENU ▼
Read by QxMD icon Read
search

Biopsy processing

keyword
https://www.readbyqxmd.com/read/28945035/-preliminary-research-on-effect-of-licorice-processed-tripterygium-wilfordii-on-reducing-liver-toxicity
#1
Xiao-Mei Zhao, Man Gong, Jie-Ming Dong, Jia-Bo Wang, Xiao-He Xiao, Kui-Jun Zhao, Zhi-Jie Ma
To explore the effect of the licorice-processed Tripterygium wilfordii on reducing the liver toxicity. In animal experiments, the liver toxicity of T. wilfordii was evaluated both before and after processing, and the differences in liver tissue biopsy, serum biochemical indexes and inflammatory cell factor among blank group, T. wilfordii group and licorice-processed T. wilfordii group were observed. Liver tissue biopsy results showed that liver tissue injury was obvious in T. wilfordii group, and no obvious injury was found in licorice-processed T...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944115/demographics-and-incidence-of-histologically-confirmed-intracranial-tumors-a-five-year-two-center-prospective-study
#2
George S Stoyanov, Deyan L Dzhenkov, Martina Kitanova, Peter Ghenev, Anton B Tonchev
Introduction Intracranial tumors (ICTs) are a diverse group of malignancies that pose an immediate threat to patients' lives, no matter their local or metastatic origin, benign or malignant nature. These lesions have severe clinical courses and need to be diagnosed and treated as soon as possible, with pathological verification being the pivotal moment in the process of determining curative modalities. Aim The aim of this study was to compare the incidence of histologically confirmed ICTs in Eastern Bulgaria, based on their type (primary, metastatic, and non-volume occupying lesions (NVOL)), their respective subtypes, and incidence in a descriptive manner...
July 16, 2017: Curēus
https://www.readbyqxmd.com/read/28942013/major-challenges-related-to-tumor-biological-characteristics-in-accurate-mutation-detection-of-colorectal-cancer-by-next-generation-sequencing
#3
Weihua Li, Tian Qiu, Lei Guo, Jianming Ying
Next-generation sequencing (NGS) has been used in mutation detection of colorectal cancer (CRC). We here interrogated 747 CRC samples to detect mutations in 22 cancer-related genes by using NGS, and to explore some key challenges related to tumor biology. RAS mutations (KRAS or NRAS mutations), RAS/BRAF/PIK3CA mutations (mutations in KRAS, NRAS, BRAF or PIK3CA) and mutation burden (mutations in any of the 22 detected genes) were observed in 53.0% (396/747), 57.1% (431/747) and 84.2% (629/747) of specimens, respectively...
September 20, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28941013/deoxycholic-acid-promotes-development-of-gastroesophageal-reflux-disease-and-barrett-s-oesophagus-by-modulating-integrin-%C3%AE-v-trafficking
#4
David O Prichard, Anne Marie Byrne, James O Murphy, John V Reynolds, Jacintha O'Sullivan, Ronan Feighery, Brendan Doyle, Osama Sharaf Eldin, Stephen P Finn, Aoife Maguire, Deirdre Duff, Dermot P Kelleher, Aideen Long
The fundamental mechanisms underlying erosive oesophagitis and subsequent development of Barrett's oesophagus (BO) are poorly understood. Here, we investigated the contribution of specific components of the gastric refluxate on adhesion molecules involved in epithelial barrier maintenance. Cell line models of squamous epithelium (HET-1A) and BO (QH) were used to examine the effects of bile acids on cell adhesion to extracellular matrix proteins (Collagen, laminin, vitronectin, fibronectin) and expression of integrin ligands (α3 , α4, α5 , α6 and αν )...
September 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28939949/focal-segmental-glomerulosclerosis-associated-with-cutaneous-and-systemic-plasmacytosis
#5
Shinsuke Isobe, Naro Ohashi, Naoko Katahashi, Sayaka Ishigaki, Naoko Tsuji, Takayuki Tsuji, Akihiko Kato, Yoshihide Fujigaki, Akira Shimizu, Hideo Yasuda
Cutaneous and systemic plasmacytosis (CSP) is a rare lymphoproliferative disorder that mainly affects middle-aged Asian individuals. Although Castleman disease is often complicated with various renal involvements, glomerulonephritis associated with CSP, which is considered as a variant of Castleman disease, is rare. This report presents the case of a 41-year-old Japanese man with nephrotic syndrome associated with CSP. Renal biopsy findings showed focal segmental glomerulosclerosis (FSGS) and diffusely mild segmental mesangial proliferation...
September 22, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28939284/modulation-of-galectin-3-and-galectin-9-in-gastric-mucosa-of-patients-with-chronic-gastritis-and-positive-helicobacter-pylori-infection
#6
Rayane Bernardes Estevam, Natalia Maria Jacom Wood da Silva, Wood da Silva, Fernanda Machado Fonseca, Adriana Gonçalves de Oliveira, Nogueira, Sanívia Aparecida de Lima Pereira, Thiago Lima Pereira, Sheila Jorge Adad, Virmondes Júnior Rodrigues, Denise Bertulucci Rocha Rodrigues
OBJECTIVES: Galectins are mediators that play an important role in the inflammatory response and in this study we analyzed the expression of Galectins (Gal) -1, -3 and -9 in biopsies of the gastric antrum of patients with upper gastrointestinal symptoms. METHODOLOGY: 44 patients with upper digestive tract symptoms were evaluated, and underwent Upper Digestive Endoscopy examination. Sections of the gastric antrum were fixed in buffered formaldehyde at 4% in order to perform the anatomopathological examination and immunohistochemical analysis for Galectins-1, -3 and -9 expression...
August 25, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28938555/exosomes-of-invasive-urothelial-carcinoma-cells-are-characterized-by-a-specific-mirna-expression-signature
#7
Sophie Baumgart, Sebastian Hölters, Carsten-Henning Ohlmann, Rainer Bohle, Michael Stöckle, Marie Stampe Ostenfeld, Lars Dyrskjøt, Kerstin Junker, Joana Heinzelmann
Muscle-invasive bladder cancer (MIBC) represents a highly aggressive tumor type compared to non-muscle-invasive tumors. MIBC is characterized by specific molecular alterations, which may also modulate extracellular tumorigenic effects. Tumor-associated exosomes, especially exosomal miRNAs, are important regulators in the interaction between tumor cells and tumor microenvironment by affecting tumor-promoting processes in target cells. It is important to analyze whether their exosomal patterns also reflect the specific molecular characteristics of MIBC...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937266/statistical-analysis-of-adcs-and-clinical-biomarkers-in-detecting-acute-renal-transplant-rejection
#8
Elizabeth Hollis, Mohamed Shehata, Mohamed Abou El-Ghar, Mohammed Ghazal, Tarek Eldiasty, Michael Merchant, Andrew E Switala, Ayman El-Baz
OBJECTIVE: To determine which parameters are correlated with transplanted kidney status in patients who have undergone kidney transplantation and can be used for early assessment of acute renal rejection. METHODS: The study included 16 patients with stable renal allografts (Group 1) and 37 patients with rejected allografts (Group 2), determined by renal biopsy post transplantation. All patients' kidneys were evaluated using diffusion-weighted MRI (DW-MRI), in which both clincal and MRI-derived biomarkers were integrated...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936478/recurrence-rate-of-melanoma-in-situ-when-treated-with-serial-disk-staged-excision-a-case-series
#9
Daniel Garcia, Robert E Eilers, S Brian Jiang
BACKGROUND: Cutaneous melanoma is one of the fastest rising cancer diagnoses in recent years. Melanoma in situ (MIS) constitutes a large proportion of all diagnosed melanomas. While surgical excision is considered the standard of therapy, the literature is not clear on which surgical technique minimizes local recurrence. A common technique is serial staged excision (SSE), in which a series of mapped excisions are made according to histopathological examination of tissue. Previously published recurrence rates for SSE ranges from 0-12%, over a range of 4...
February 2017: Journal of Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28936404/-18-f-fdg-pet-for-assessing-biological-viability-and-prognosis-in-liver-transplant-patients-with-hepatocellular-carcinoma
#10
REVIEW
Arno Kornberg, Martina Schernhammer, Helmut Friess
Liver transplantation (LT) has become standard of care in patients with non-resectable early stage hepatocellular carcinoma (HCC) in liver cirrhosis. Currently, patient selection for LT is strictly based on tumor size and number, provided by the Milan criteria. This may, however, exclude patients with advanced tumor load but favourable biology from a possibly curative treatment option. It became clear in recent years that biological tumor viability rather than tumor macromorphology determines posttransplant outcome...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28935210/office-based-procedures-for-the-diagnosis-and-treatment-of-laryngeal-pathology
#11
REVIEW
David J Wellenstein, Henrieke W Schutte, Robert P Takes, Jimmie Honings, Henri A M Marres, James A Burns, Guido B van den Broek
INTRODUCTION: Since the development of distal chip endoscopes with a working channel, diagnostic and therapeutic possibilities in the outpatient clinic in the management of laryngeal pathology have increased. Which of these office-based procedures are currently available, and their clinical indications and possible advantages, remains unclear. MATERIAL AND METHODS: Review of literature on office-based procedures in laryngology and head and neck oncology. RESULTS: Flexible endoscopic biopsy (FEB), vocal cord injection, and laser surgery are well-established office-based procedures that can be performed under topical anesthesia...
September 18, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28932925/hepatic-complications-of-anorexia-nervosa
#12
REVIEW
Elissa Rosen, Neeru Bakshi, Ashlie Watters, Hugo R Rosen, Philip S Mehler
Anorexia nervosa (AN) has the highest mortality rate of all psychiatric illnesses due to the widespread organ dysfunction caused by the underlying severe malnutrition. Starvation causes hepatocyte injury and death leading to a rise in aminotransferases. Malnutrition-induced hepatitis is common among individuals with AN especially as body mass index decreases. Acute liver failure associated with coagulopathy and encephalopathy can rarely occur. Liver enzymes may also less commonly increase as part of the refeeding process due to hepatic steatosis and can be distinguished from starvation hepatitis by the finding of a fatty liver on ultrasonography...
September 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28932153/oral-squamous-cell-carcinoma-masquerading-as-gingival-overgrowth
#13
Roshni Ramesh, Arun Sadasivan
Gingival enlargements are frequently encountered in dental practice. There are different types of gingival enlargements and they vary according to the etiologic factors and pathologic processes that produce them. The exact diagnosis of the enlargement is important as some gingival enlargements can cause extensive morbidity or even mortality. Oral cancers especially squamous cell carcinomas present with variations in clinical presentation and the sites affected. A detailed medical history, clinical examination and radiographic evaluation will help identify the lesion...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28928357/successful-dual-kidney-transplantation-after-hypothermic-oxygenated-perfusion-of-discarded-human-kidneys
#14
Matteo Ravaioli, Vanessa De Pace, Giorgia Comai, Marco Busutti, Massimo Del Gaudio, Annalisa Amaduzzi, Alessandro Cucchetti, Antonio Siniscalchi, Gaetano La Manna, Antonietta A D D'Errico, Antonio Daniele Pinna
BACKGROUND The recovery of discarded human kidneys has increased in recent years and impels to use of unconventional organ preservation strategies that improve graft function. We report the first case of human kidneys histologically discarded and transplanted after hypothermic oxygenated perfusion (HOPE). CASE REPORT Marginal kidneys from a 78-year-old woman with brain death were declined by Italian transplant centers due to biopsy score (right kidney: 6; left kidney: 7). We recovered and preserved both kidneys through HOPE and we revaluated their use for transplantation by means of perfusion parameters...
September 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28927212/fluorescein-guided-neuroendoscopy-for-intraventricular-lesions-a-case-series
#15
Alessandro Fiorindi, Alessandro Boaro, Giulia Del Moro, Pierluigi Longatti
BACKGROUND: The benefits of neuroendoscopy in the pathological diagnosis of intra- and paraventricular tumors have already been shown in many neurosurgical studies. However, most authors agree that neuroendoscopic biopsies are not infrequently inconclusive due to small or inadequate samples, prompting the need for new diagnostic strategies. OBJECTIVE: To describe a technique not previously reported in the literature, combining neuroendoscopy with angiofluorescein guidance for the pathological diagnosis of intra- and paraventricular tumors...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28925390/alterations-of-micrornas-throughout-the-malignant-evolution-of-cutaneous-squamous-cell-carcinoma-the-role-of-mir-497-in-epithelial-to-mesenchymal-transition-of-keratinocytes
#16
A Mizrahi, A Barzilai, D Gur-Wahnon, I Z Ben-Dov, S Glassberg, T Meningher, E Elharar, M Masalha, J Jacob-Hirsch, H Tabibian-Keissar, I Barshack, J Roszik, R Leibowitz-Amit, Y Sidi, D Avni
Skin carcinogenesis is known to be a multi-step process with several stages along its malignant evolution. We hypothesized that transformation of normal epidermis to cutaneous squamous cell carcinoma (cSCC) is causally linked to alterations in microRNAs (miRNA) expression. For this end we decided to evaluate their alterations in the pathologic states ending in cSCC. Total RNA was extracted from formalin fixed paraffin embedded biopsies of five stages along the malignant evolution of keratinocytes towards cSCC: Normal epidermis, solar elastosis, actinic keratosis KIN1-2, advanced actinic keratosis KIN3 and well-differentiated cSCC...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28922518/accelerated-epithelialization-and-improved-wound-healing-metrics-in-porcine-full-thickness-wounds-transplanted-with-full-thickness-skin-micrografts
#17
Christina L Rettinger, John L Fletcher, Anders H Carlsson, Rodney K Chan
Split-thickness skin grafting (STSG) is the current gold standard for treatment of extensive burn and traumatic skin injuries. However, STSG is limited by donor-site morbidity and availability, and often leads to scarring and wound contracture. Furthermore, these thin grafts lack dermal elements such as nerves and adnexa which are important in recapitulating normal skin function. Methods of fractional skin replacement either as minced STSGs or microscopic skin tissue columns (MSTCs) have been proposed, though these techniques have not been fully-characterized and lack evidence of regenerated adnexal structures...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28916757/muscle-pathology-from-stochastic-low-level-dux4-expression-in-an-fshd-mouse-model
#18
Darko Bosnakovski, Sunny S K Chan, Olivia O Recht, Lynn M Hartweck, Collin J Gustafson, Laura L Athman, Dawn A Lowe, Michael Kyba
Facioscapulohumeral muscular dystrophy is a slowly progressive but devastating myopathy caused by loss of repression of the transcription factor DUX4; however, DUX4 expression is very low, and protein has not been detected directly in patient biopsies. Efforts to model DUX4 myopathy in mice have foundered either in being too severe, or in lacking muscle phenotypes. Here we show that the endogenous facioscapulohumeral muscular dystrophy-specific DUX4 polyadenylation signal is surprisingly inefficient, and use this finding to develop an facioscapulohumeral muscular dystrophy mouse model with muscle-specific doxycycline-regulated DUX4 expression...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28916027/oral-leukoplakia-and-oral-cavity-squamous-cell-carcinoma
#19
Arnaud F Bewley, D Gregory Farwell
Oral leukoplakia is defined as a white oral lesion not related to another disease process. These lesions are largely asymptomatic, and the clinical relevance of oral leukoplakia is primarily tied to its association with oral cavity squamous cell carcinoma. Timely workup and effective management of these lesions can reduce the risk of malignant transformation and promote early diagnosis of invasive tumors. A biopsy should be performed promptly of any persistent or suspicious leukoplakia with subsequent management dictated by histologic findings...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28915272/receptor-and-post-receptor-abnormalities-contribute-to-insulin-resistance-in-myotonic-dystrophy-type-1-and-type-2-skeletal-muscle
#20
Laura Valentina Renna, Francesca Bosè, Sara Iachettini, Barbara Fossati, Lorenzo Saraceno, Valentina Milani, Roberto Colombo, Giovanni Meola, Rosanna Cardani
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant multisystemic disorders caused by expansion of microsatellite repeats. In both forms, the mutant transcripts accumulate in nuclear foci altering the function of alternative splicing regulators which are necessary for the physiological mRNA processing. Missplicing of insulin receptor (IR) gene (INSR) has been associated with insulin resistance, however, it cannot be excluded that post-receptor signalling abnormalities could also contribute to this feature in DM...
2017: PloS One
keyword
keyword
19992
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"