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https://www.readbyqxmd.com/read/28655195/positive-autobiographical-memory-retrieval-reduces-temporal-discounting
#1
Karolina M Lempert, Megan E Speer, Mauricio R Delgado, Elizabeth A Phelps
People generally prefer rewards sooner rather than later. This phenomenon, temporal discounting, underlies many societal problems, including addiction and obesity. One way to reduce temporal discounting is to imagine positive future experiences. Since there is overlap in the neural circuitry associated with imagining future experiences and remembering past events, here we investigate whether recalling positive memories can also promote more patient choice. We found that participants were more patient after retrieving positive autobiographical memories, but not when they recalled negative memories...
June 26, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28654912/identification-of-dysregulated-long-non-coding-rnas-micrornas-mrnas-in-tnm-i-stage-lung-adenocarcinoma
#2
Ziqiang Tian, Shiwang Wen, Yuefeng Zhang, Xinqiang Shi, Yonggang Zhu, Yanzhao Xu, Huilai Lv, Guiying Wang
Lung adenocarcinoma (LUAD) is the primary subtype in lung cancer, which is the leading cause of cancer-related death worldwide. This study aimed to investigate the aberrant expression profiling of long non-coding RNA (lncRNA) in TNM I stage (stage I) LUAD. The lncRNA/mRNA/miRNA expression profiling of stage I LUAD and adjacent non-tumor tissues from 4 patients were measured by RNA-sequencing. Total of 175 differentially expressed lncRNAs (DELs), 1321 differentially expressed mRNAs (DEMs) and 94 differentially expressed microRNAs (DEMIs) were identified in stage I LUAD...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654658/butyrate-modifies-intestinal-barrier-function-in-ipec-j2-cells-through-a-selective-upregulation-of-tight-junction-proteins-and-activation-of-the-akt-signaling-pathway
#3
Hui Yan, Kolapo M Ajuwon
The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and intestinal secretions, prevents passage of luminal substances and antigens through the paracellular space. Dysfunction of the intestinal barrier integrity induced by toxins and pathogens is associated with a variety of gastrointestinal disorders and diseases. Although butyrate is known to enhance intestinal health, its role in the protection of intestinal barrier function is poorly characterized. Therefore, we investigated the effect of butyrate on intestinal epithelial integrity and tight junction permeability in a model of LPS-induced inflammation in IPEC-J2 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28654639/improvement-of-atropine-on-esophagogastric-junction-observation-during-sedative-esophagogastroduodenoscopy
#4
Zhihao Chen, Lingang Liu, Jiangfeng Tu, Guangming Qin, Weiwei Su, Xiaoge Geng, Xiaojun Chen, Hongguang Wu, Wensheng Pan
BACKGROUND AND STUDY AIMS: Although sedation esophagogastroduodenoscopy (EGD) is now widely used, previous research has reported that sedation during EGD exhibits a negative effect on esophagogastric junction (EGJ) exposure. Atropine might improve EGJ exposure, as noted in clinical practice. The aim of this study was to examine whether sedation had a negative effect on EGJ observation in the Chinese population, and whether atropine had some ability to act as an antidote to this unexpected secondary effect of sedation...
2017: PloS One
https://www.readbyqxmd.com/read/28654468/bullous-pemphigoid-use-of-c4d-immunofluorescent-staining-in-a-case-with-repeated-negative-conventional-direct-immunofluorescence-studies
#5
Sarah S Kassaby, Alexander Hicks, Stuart Leicht, George A Youngberg
Direct immunofluorescence (DIF) using frozen section material from a fresh/preserved perilesional biopsy is the gold standard for the immunopathologic diagnosis of bullous pemphigoid (BP). DIF in BP shows linear dermoepidermal junction (DEJ) staining for C3, with or without staining for IgG. In some situations, only a formalin-fixed lesional biopsy is obtained (with no fresh/preserved perilesional biopsy for DIF). In this setting, paraffin section C4d immunohistochemistry has proven to be diagnostically useful, demonstrating linear DEJ positivity for C4d...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654245/effects-of-in-utero-pfos-exposure-on-transcriptome-lipidome-and-function-of-mouse-testis
#6
Keng Po Lai, Jetty Chung-Yung Lee, Hin Ting Wan, Jing Woei Li, Aman Yi-Man Wong, Ting-Fung Chan, Camille Oger, Jean-Marie Galano, Thierry Durand, Kin Sum Leung, Cherry C Leung, Rong Li, Chris Kong-Chu Wong
Transcriptomic and LC-MS/MS-based targeted lipidomic analyses were conducted to identify the effects of in utero PFOS exposure on neonatal testes and its relation to testicular dysfunction in adult offspring. Pregnant mice were orally administered 0.3 and 3 µg PFOS/g body weight until term. Neonatal testes (P1) were collected for the detection of PFOS, and were subjected to omics study. Integrated pathway analyses using DAVID, KEGG and IPA underlined the effects of PFOS exposure on lipid metabolism, oxidative stress and cell junction signaling in testes...
June 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28654075/clock-scan-protocol-for-image-analysis-imagej-plugins
#7
Maxim Dobretsov, Georg Petkau, Abdallah Hayar, Eugen Petkau
The clock scan protocol for image analysis is an efficient tool to quantify the average pixel intensity within, at the border, and outside (background) a closed or segmented convex-shaped region of interest, leading to the generation of an averaged integral radial pixel-intensity profile. This protocol was originally developed in 2006, as a visual basic 6 script, but as such, it had limited distribution. To address this problem and to join similar recent efforts by others, we converted the original clock scan protocol code into two Java-based plugins compatible with NIH-sponsored and freely available image analysis programs like ImageJ or Fiji ImageJ...
June 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654072/subcutaneous-neurotrophin-4-infusion-using-osmotic-pumps-or-direct-muscular-injection-enhances-aging-rat-laryngeal-muscles
#8
Richard D Andreatta, Joseph C Stemple, Tanya S Seward, Colleen A McMullen
Laryngeal dysfunction in the elderly is a major cause of disability, from voice disorders to dysphagia and loss of airway protective reflexes. Few, if any, therapies exist that target age-related laryngeal muscle dysfunction. Neurotrophins are involved in muscle innervation and differentiation of neuromuscular junctions (NMJs). It is thought that neurotrophins enhance neuromuscular transmission by increasing neurotransmitter release. The neuromuscular junctions (NMJs) become smaller and less abundant in aging rat laryngeal muscles, with evidence of functional denervation...
June 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654067/bidirectional-retroviral-integration-site-pcr-methodology-and-quantitative-data-analysis-workflow
#9
Gajendra W Suryawanshi, Song Xu, Yiming Xie, Tom Chou, Namshin Kim, Irvin S Y Chen, Sanggu Kim
Integration Site (IS) assays are a critical component of the study of retroviral integration sites and their biological significance. In recent retroviral gene therapy studies, IS assays, in combination with next-generation sequencing, have been used as a cell-tracking tool to characterize clonal stem cell populations sharing the same IS. For the accurate comparison of repopulating stem cell clones within and across different samples, the detection sensitivity, data reproducibility, and high-throughput capacity of the assay are among the most important assay qualities...
June 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654065/analysis-of-the-gap-junction-dependent-transfer-of-mirna-with-3d-frap-microscopy
#10
Heiko Lemcke, Natalia Voronina, Gustav Steinhoff, Robert David
Small antisense RNAs, like miRNA and siRNA, play an important role in cellular physiology and pathology and, moreover, can be used as therapeutic agents in the treatment of several diseases. The development of new, innovative strategies for miRNA/siRNA therapy is based on an extensive knowledge of the underlying mechanisms. Recent data suggest that small RNAs are exchanged between cells in a gap junction-dependent manner, thereby inducing gene regulatory effects in the recipient cell. Molecular biological techniques and flow cytometric analysis are commonly used to study the intercellular exchange of miRNA...
June 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654012/i-v-and-c-v-characterization-of-a-high-responsivity-graphene-silicon-photodiode-with-embedded-mos-capacitor
#11
Giuseppe Luongo, Filippo Giubileo, Luca Genovese, Laura Iemmo, Nadia Martucciello, Antonio Di Bartolomeo
We study the effect of temperature and light on the I-V and C-V characteristics of a graphene/silicon Schottky diode. The device exhibits a reverse-bias photocurrent exceeding the forward current and achieves a photoresponsivity as high as 2.5 A / W . We show that the enhanced photocurrent is due to photo-generated carriers injected in the graphene/Si junction from the parasitic graphene/SiO₂/Si capacitor connected in parallel to the diode. The same mechanism can occur with thermally generated carriers, which contribute to the high leakage current often observed in graphene/Si junctions...
June 27, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28653984/multiple-isoforms-of-anril-in-melanoma-cells-structural-complexity-suggests-variations-in-processing
#12
Debina Sarkar, Ali Oghabian, Pasani K Bodiyabadu, Wayne R Joseph, Euphemia Y Leung, Graeme J Finlay, Bruce C Baguley, Marjan E Askarian-Amiri
The long non-coding RNA ANRIL, antisense to the CDKN2B locus, is transcribed from a gene that encompasses multiple disease-associated polymorphisms. Despite the identification of multiple isoforms of ANRIL, expression of certain transcripts has been found to be tissue-specific and the characterisation of ANRIL transcripts remains incomplete. Several functions have been associated with ANRIL. In our judgement, studies on ANRIL functionality are premature pending a more complete appreciation of the profusion of isoforms...
June 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28653722/porous-pdms-structures-for-the-storage-and-release-of-aqueous-solutions-into-fluidic-environments
#13
Peter Thurgood, Sara Baratchi, Crispin Szydzik, Arnan Mitchell, Khashayar Khoshmanesh
Typical microfluidic systems take advantage of multiple storage reservoirs, pumps and valves for the storage, driving and release of buffers and other reagents. However, the fabrication, integration, and operation of such components can be difficult. In particular, the reliance of such components on external off-chip equipment limits their utility for creating self-sufficient, stand-alone microfluidic systems. Here, we demonstrate a porous sponge made of polydimethylsiloxane (PDMS), which is fabricated by templating microscale water droplets using a T-junction microfluidic structure...
June 27, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28653159/could-a-feeding-jejunostomy-be-integrated-into-a-standardized-preoperative-management-of-oeso-gastric-junction-adenocarcinoma
#14
Simone Manfredelli, Jean-Baptiste Delhorme, Aïna Venkatasamy, Christian Gaiddon, Cécile Brigand, Serge Rohr, Benoît Romain
PURPOSE: To evaluate the impact of a feeding jejunostomy (FJ) on the preoperative management of patients with an oesogastric adenocarcinoma (OGA). METHODS: From January 2007 to December 2014, patients with potentially resectable OGA were enrolled in a perioperative chemotherapy protocol. FJ was performed before starting perioperative treatments in patients presenting with dysphagia or with a nutritional risk index (NRI) <97.5. The patients who did not require a FJ served as a control group...
June 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28653157/computational-analysis-on-down-regulated-images-of-macrophage-scavenger-receptor
#15
Byeongtaek Oh, Yugyung Lee, Mingui Fu, Chi H Lee
BACKGROUND: Thiolated-graphene quantum dots (SH-GQDs) were developed and assessed for an efficient preventive means against atherosclerosis and potential toxicity through computational image analysis and animal model studies. EXPERIMENTS: Zebrafish (wild-type, wt) were used for evaluation of toxicity through the assessment of embryonic mortality, malformation and ROS generation. The amounts of SH-GQDs uptaken by mouse macrophage cells (Raw264.7) were analyzed using a flow cytometer...
June 26, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28652736/magnetic-alginate-microspheres-detected-by-mri-fabricated-using-microfluidic-technique-and-release-behavior-of-encapsulated-dual-drugs
#16
Qin Wang, Shanshan Liu, Fan Yang, Lu Gan, Xiangliang Yang, Yajiang Yang
Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28652650/role-of-non-steroidal-anti-inflammatory-drugs-on-intestinal-permeability-and-nonalcoholic-fatty-liver-disease
#17
REVIEW
Erika Utzeri, Paolo Usai
The use of non-steroidal anti-inflammatory drugs (NSAIDs) is widespread worldwide thanks to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is placed upon the recurrence of digestive system complications in the course of their use. Recent data suggests that the complications of the lower gastro-intestinal tract may be as frequent and severe as those of the upper tract. NSAIDs enteropathy is due to enterohepatic recycling of the drugs resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28652265/a-massively-parallel-fluorescence-assay-to-characterize-the-effects-of-synonymous-mutations-on-tp53-expression
#18
Geetha Bhagavatula, Matthew S Rich, David L Young, Maximillian Marin, Stanley Fields
Although synonymous mutations can affect gene expression, they have generally not been considered in genomic studies that focus on mutations that increase the risk of cancer. However, mounting evidence implicates some synonymous mutations as driver mutations in cancer. Here a massively parallel assay, based on cell sorting of a reporter containing a segment of p53 fused to green fluorescent protein (GFP), was used to measure the effects of nearly all synonymous mutations in exon 6 of TP53. In this reporter context, several mutations within the exon caused strong expression changes including mutations that may cause potential gain or loss of function...
June 26, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28652146/downregulation-of-pkc%C3%AE-pard3-pard6b-is-responsible-for-lung-adenocarcinoma-cell-emt-and-invasion
#19
Qiyuan Zhou, Jingbo Dai, Tianji Chen, Laura A Dada, Xu Zhang, Wei Zhang, Malcolm M DeCamp, Robert A Winn, Jacob I Sznajder, Guofei Zhou
Atypical protein kinase C ζ (PKCζ) forms an apico-basal polarity complex with Partitioning Defective (Pard) 3 and Pard6 to regulate normal epithelial cell apico-basolateral polarization. The dissociation of the PKCζ/Pard3/Pard6 complex is essential for the disassembly of the tight/adherens junction and epithelial-mesenchymal transition (EMT) that is critical for tumor spreading. Loss of cell polarity and epithelial organization is strongly correlated with malignancy and tumor progression in some other cancer types...
June 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28652124/ureterocalicostomy-for-reconstruction-of-complicated-ureteropelvic-junction-obstruction-in-adults-long-term-outcome-factors-predicting-its-failure-in-contemporary-cohort
#20
Devarshi Srivastava, Sanjoy K Sureka, Priyank Yadav, Ankur Bansal, Shashikant Gupta, Rakesh Kapoor, M S Ansari, Aneesh Srivastava
INTRODUCTION: Ureterocalicostomy (UC) is a well-established treatment option for patients with recurrent ureteropelvic junction obstruction (UPJO) with postoperative fibrosis and a relatively inaccessible renal pelvis. This study aimed to evaluate the long-term outcome of UC and factors predicting its failure. MATERIALS AND METHODS: We retrospectively analysed data of 72 patients who underwent open or laparoscopic UC from 2000 to 2014. Variables that may affect the outcomes of UC were assessed with regard to primary pathology, age, serum creatinine, preoperative renal size (<15 cm and > 15 cm), renal cortical thickness (<5mm and >5 mm), grade of hydronephrosis and preoperative renal function (GFR < or >20 ml/min)...
June 23, 2017: Journal of Urology
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