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https://www.readbyqxmd.com/read/29786620/the-effect-of-bottom-electrode-on-ferroelectric-tunnel-junctions-based-on-cmos-compatible-hfo2
#1
Youngin Goh, Sanghun Jeon
Ferroelectric tunnel junctions (FTJs) have attracted research interest as promising candidates for non-destructive readout non-volatile memories. Unlike conventional perovskite FTJs, hafnia FTJ offers many advantages in terms of scalability and CMOS compatibility. However, so far, hafnia FTJ has shown poor endurance and relatively low resistance ratio and these have remained the issue for real device applications. In our study, we fabricated HfZrO-based FTJ with various electrodes (TiN, Si, SiGe, Ge) and improved the memory performance of HfZrO-based FTJ by using the asymmetry of the charge screening lengths of the electrodes...
May 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29786451/annexin-a2-is-a-robo4-ligand-that-modulates-arf6-activation-associated-cerebral-trans-endothelial-permeability
#2
Wenlu Li, Zhigang Chen, Jing Yuan, Zhanyang Yu, Chongjie Cheng, Qiuchen Zhao, Lena Huang, Katherine A Hajjar, Zhong Chen, Eng H Lo, Haibin Dai, Xiaoying Wang
Blood-brain barrier (BBB) disruption in neurological disorders remains an intractable problem with limited therapeutic options. Here, we investigate whether the endothelial cell membrane protein annexin A2 (ANXA2) may play a role in reducing trans-endothelial permeability and maintaining cerebrovascular integrity after injury. Compared with wild-type mice, the expression of cerebral endothelial junctional proteins was reduced in E15.5 and adult ANXA2 knockout mice, along with increased leakage of small molecule tracers...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29786431/ultrasonic-assisted-spin-coating-improved-junction-by-enhanced-permeation-of-coating-material-within-nanostructures
#3
Jong-Won Yun, Farman Ullah, Se-Jeong Jang, Do Hui Kim, Tri Khoa Nguyen, Ki Yeon Ryu, Shinuk Cho, Joon I Jang, Dooyong Lee, Sungkyun Park, Yong Soo Kim
Over the last decades, the spin coating (SC) technique has been widely used to prepare thin films of various materials in liquid phase on arbitrary substrates. The technique simply relies on centrifugal force to spread a coating solution radially outwards over the substrate. This mechanism works fairly well for solutions with low surface tension to form thin films of reasonable junctions on smooth substrates. Here, we present a modified SC technique, namely ultrasonic-assisted spin-coating (UASC), to form thin films of coating solution having high surface tension on rough substrates with excellent junctions...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786119/full-length-and-defective-enterovirus-g-genomes-with-distinct-torovirus-protease-insertions-are-highly-prevalent-on-a-chinese-pig-farm
#4
Yan Wang, Wen Zhang, Zhijian Liu, Xingli Fu, Jiaqi Yuan, Jieji Zhao, Yuan Lin, Quan Shen, Xiaochun Wang, Xutao Deng, Eric Delwart, Tongling Shan, Shixing Yang
Recombination occurs frequently between enteroviruses (EVs) which are classified within the same species of the Picornaviridae family. Here, using viral metagenomics, the genomes of two recombinant EV-Gs (strains EVG 01/NC_CHI/2014 and EVG 02/NC_CHI/2014) found in the feces of pigs from a swine farm in China are described. The two strains are characterized by distinct insertion of a papain-like protease gene from toroviruses classified within the Coronaviridae family. According to recent reports the site of the torovirus protease insertion was located at the 2C/3A junction region in EVG 02/NC_CHI/2014...
May 21, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29785754/expression-of-zo-1-and-claudin-1-in-a-3d-epidermal-equivalent-using-canine-progenitor-epidermal-keratinocytes
#5
Keiji Teramoto, Ryota Asahina, Hidetaka Nishida, Hiroaki Kamishina, Sadatoshi Maeda
BACKGROUND: Previous studies indicate that tight junctions are involved in the pathogenesis of canine atopic dermatitis (cAD). An in vitro skin model is needed to elucidate the specific role of tight junctions in cAD. A 3D epidermal equivalent model using canine progenitor epidermal keratinocytes (CPEK) has been established; the expression of tight junctions within this model is uncharacterized. HYPOTHESIS/OBJECTIVES: To investigate the expression of tight junctions in the 3D epidermal equivalent...
May 21, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29785723/decreased-e-cadherin-in-mcf7-human-breast-cancer-cells-forming-multicellular-spheroids-exposed-to-simulated-microgravity
#6
Jayashree Sahana, Mohamed Zakaria Nassef, Markus Wehland, Sascha Kopp, Marcus Krüger, Thomas J Corydon, Manfred Infanger, Johann Bauer, Daniela Grimm
MCF7 human breast cancer cells were cultured under normal gravity (1g) and on a random positioning machine (RPM) preventing sedimentation. After two weeks, adherent 1g-control and adherent RPM cells (AD) as well as multicellular spheroids (MCS) were harvested. AD and MCS had been exposed to the RPM in the same culture flask. In a subsequent proteome analysis, the majority of the proteins detected showed similar label-free quantification scores (LFQ) in each of the respective subpopulations, but in both AD or MCS cultures, proteins were also found whose LFQs deviated at least twofold from their counterparts in the 1g-control cells...
May 21, 2018: Proteomics
https://www.readbyqxmd.com/read/29785556/bilateral-simultaneous-santosh-post-graduate-institute-tubularized-flap-pyelovesicostomy-in-a-case-of-bilateral-pelvi-ureteric-junction-obstruction-with-bilateral-giant-hydronephrosis
#7
Santosh Kumar, Ashish Khanna, Kalpesh Parmar, Abhishek Chandna, Subhajit Mandal, Vignesh Manoharan
We present a case of bilateral giant hydronephrosis (HDN) secondary to bilateral pelvi-ureteric junction obstruction (PUJO) in a young girl, managed successfully by robot-assisted bilateral tubularized flap pyelo-vesicostomy. This case report highlights the feasibility, reproducibility and technicalities of this procedure.
May 21, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29785346/integrated-bioinformatic-changes-and-analysis-of-retina-with-time-in-diabetic-rats
#8
Zekai Cui, Qiaolang Zeng, Yonglong Guo, Shiwei Liu, Jiansu Chen
Diabetic retinopathy (DR) is the most common chronic complication of diabetes. It can cause impaired vision and even blindness. However, the pathological mechanism of DR is still unknown. In the present study, we use bioinformatic analysis to reveal the pathological changes of early DR in a streptozotocin (STZ) induced diabetes rat model. The dataset GSE28831 was downloaded from the Gene Expression Omnibus (GEO) database. To clarify the pathological mechanism of early DR, genes which were up-regulated (UP group) or down-regulated (DOWN group) over time were identified...
2018: PeerJ
https://www.readbyqxmd.com/read/29785054/correlating-the-nanostructure-of-al-oxide-with-deposition-conditions-and-dielectric-contributions-of-two-level-systems-in-perspective-of-superconducting-quantum-circuits
#9
S Fritz, A Seiler, L Radtke, R Schneider, M Weides, G Weiß, D Gerthsen
This work is concerned with Al/Al-oxide(AlOx )/Al-layer systems which are important for Josephson-junction-based superconducting devices such as quantum bits. The device performance is limited by noise, which has been to a large degree assigned to the presence and properties of two-level tunneling systems in the amorphous AlOx tunnel barrier. The study is focused on the correlation of the fabrication conditions, nanostructural and nanochemical properties and the occurrence of two-level tunneling systems with particular emphasis on the AlOx -layer...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29785052/observation-of-anisotropic-magneto-peltier-effect-in-nickel
#10
Ken-Ichi Uchida, Shunsuke Daimon, Ryo Iguchi, Eiji Saitoh
The Peltier effect, discovered in 1834, converts a charge current into a heat current in a conductor, and its performance is described by the Peltier coefficient, which is defined as the ratio of the generated heat current to the applied charge current1,2 . To exploit the Peltier effect for thermoelectric cooling or heating, junctions of two conductors with different Peltier coefficients have been believed to be indispensable. Here we challenge this conventional wisdom by demonstrating Peltier cooling and heating in a single material without junctions...
May 21, 2018: Nature
https://www.readbyqxmd.com/read/29785030/landau-zener-st%C3%A3-ckelberg-interferometry-for-majorana-qubit
#11
Zhi Wang, Wen-Chao Huang, Qi-Feng Liang, Xiao Hu
Stimulated by a recent experiment observing successfully two superconducting states with even- and odd-number of electrons in a nanowire topological superconductor as expected from the existence of two end Majorana quasiparticles (MQs) [Albrecht et al., Nature 531, 206 (2016)], we propose a way to manipulate Majorana qubit exploiting quantum tunneling effects. The prototype setup consists of two one-dimensional (1D) topological superconductors coupled by a tunneling junction which can be controlled by gate voltage...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784924/allergy-immunotherapy-restores-airway-epithelial-barrier-dysfunction-through-suppressing-il-25-induced-endoplasmic-reticulum-stress-in-asthma
#12
Xiefang Yuan, Junyi Wang, Yin Li, Xiang He, Bin Niu, Dehong Wu, Nan Lan, Xiaoyun Wang, Yun Zhang, Xi Dai, Xing Wang, Zhigang Liu, Guoping Li
Constant exposure to allergen triggers destructive type 2 cell-mediated inflammation. The effect of allergen specific immunotherapy (SIT) in maintaining airway epithelial barrier function in asthma remains unknown. In the current study, we showed that SIT maintained airway epithelial homeostasis in mice exposed to dermatophagoides farinae (Der f), which induced increased expression of IL-25, endoplasmic reticulum (ER) stress and airway epithelial apoptosis. Meanwhile, SIT treatment ameliorated airway inflammatory infiltration and hyper-responsiveness in allergic mice...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784671/a-non-autonomous-function-of-the-core-pcp-protein-vangl2-directs-peripheral-axon-turning-in-the-developing-cochlea
#13
Satish R Ghimire, Evan M Ratzan, Michael R Deans
The cochlea is innervated by neurons that relay sound information from hair cells to central auditory targets. A subset of these are the TypeΙΙ spiral ganglion neurons which have nociceptive features and contribute to feedback circuits providing neuroprotection in extreme noise. TypeΙΙ neurons make a distinctive 90 degree turn towards the cochlear base to synapse with 10-15 outer hair cells. We demonstrate that this axon turning event requires Planar Cell Polarity (PCP) signaling, is disrupted in Vangl2 and Celsr1 knockout mice, and that VANGL2 acts non-autonomously from the cochlea to direct turning...
May 21, 2018: Development
https://www.readbyqxmd.com/read/29784594/the-effect-of-increasing-catheter-distance-from-the-deep-junction-on-the-outcomes-of-radiofrequency-vein-ablation
#14
Afsha Aurshina, Yawei Zhang, Fang Wang, Jonathan Cardella, Kristine Orion, Bauer Sumpio, Timur Sarac, Cassius Iyad Ochoa Chaar
OBJECTIVE: Thermal vein ablation (VA) is the recommended treatment modality for superficial venous reflux, with a recommended positioning of the catheter at 2 to 3 cm from the junction of the deep venous system. In contrast, novel sealing technology for saphenous VA involves treatment starting at 3 to 5 cm distal to the deep junction. This study examines the effect of increasing catheter distance from the junction on the outcomes of VA using radiofrequency. METHODS: A retrospective single-center review of patients treated with VA was performed...
May 18, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29784491/neonatal-and-pediatric-arrhythmias-clinical-and-electrocardiographic-aspects
#15
REVIEW
Fabrizio Drago, Irma Battipaglia, Corrado Di Mambro
Arrhythmias have acquired a specific identity in pediatric cardiology, but for pediatric cardiologists it has always been difficult to recognize and treat them. Changes in anatomy and physiology result in electrocardiogram features that differ from the normal adult pattern and vary according to the age of the child. Sinus arrhythmia, ectopic atrial rhythm, "wandering pacemaker," and junctional rhythm can be normal characteristics in children (15%-25% of healthy children can have these rhythms on the electrocardiogram)...
June 2018: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29784483/ectopic-beats-insights-from-timing-and-morphology
#16
REVIEW
Giuseppe Bagliani, Domenico Giovanni Della Rocca, Roberto De Ponti, Alessandro Capucci, Margherita Padeletti, Andrea Natale
Premature complexes are electrical impulses arising from atrial, junctional, or ventricular tissue, leading to premature heart beats. Premature atrial beats are much more frequent than those arising in the atrioventricular junction but less frequent than premature beats from the ventricles. Although they are usually benign and highly prevalent in the general population, they could trigger sustained supraventricular and ventricular arrhythmias, and cause cardiomyopathies. The aim of this article was to review the main electrocardiology features of premature complexes and discuss their implications in clinical practice...
June 2018: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29784382/the-application-of-a-spectrophotometric-method-to-determine-ph-in-acidic-ph-5-soils
#17
Sima Bargrizan, Ronald J Smernik, Rob W Fitzpatrick, Luke M Mosley
pH is a "master variable" controlling many biogeochemical processes in soils. Acid sulfate soils undergo rapid and large pH changes from circumneutral pH under anaerobic soil conditions to sulfuric soils with ultra (pH < 3.5) and extremely (pH 3.5-4.4) acidic properties following oxidation. Measuring soil pH using a glass electrode has several potential drawbacks including liquid junction errors, drift, suspension effects and clogging. Spectrophotometric pH measurement, involving addition of an indicator dye to the sample, is widely used in seawater and has recently been developed for soil extracts at circumneutral pH ranges...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783994/large-scale-transcriptomic-analysis-reveals-that-pridopidine-reverses-aberrant-gene-expression-and-activates-neuroprotective-pathways-in-the-yac128-hd-mouse
#18
Rebecca Kusko, Jennifer Dreymann, Jermaine Ross, Yoonjeong Cha, Renan Escalante-Chong, Marta Garcia-Miralles, Liang Juin Tan, Michael E Burczynski, Ben Zeskind, Daphna Laifenfeld, Mahmoud Pouladi, Michal Geva, Iris Grossman, Michael R Hayden
BACKGROUND: Huntington Disease (HD) is an incurable autosomal dominant neurodegenerative disorder driven by an expansion repeat giving rise to the mutant huntingtin protein (mHtt), which is known to disrupt a multitude of transcriptional pathways. Pridopidine, a small molecule in development for treatment of HD, has been shown to improve motor symptoms in HD patients. In HD animal models, pridopidine exerts neuroprotective effects and improves behavioral and motor functions. Pridopidine binds primarily to the sigma-1 receptor, (IC50 ~ 100 nM), which mediates its neuroprotective properties, such as rescue of spine density and aberrant calcium signaling in HD neuronal cultures...
May 21, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29783744/interplay-between-er-ca-2-binding-proteins-stim1-and-stim2-is-required-for-store-operated-ca-2-entry
#19
Heather A Nelson, Colin A Leech, Richard F Kopp, Michael W Roe
Store-operated calcium entry (SOCE), a fundamentally important homeostatic and Ca2+ signaling pathway in many types of cells, is activated by the direct interaction of stromal interaction molecule 1 (STIM1), an endoplasmic reticulum (ER) Ca2+ -binding protein, with Ca2+ -selective Orai1 channels localized in the plasma membrane. While much is known about the regulation of SOCE by STIM1, the role of stromal interaction molecule 2 (STIM2) in SOCE remains incompletely understood. Here, using clustered regularly interspaced short palindromic repeats -CRISPR associated protein 9 (CRISPR-Cas9) genomic editing and molecular imaging, we investigated the function of STIM2 in NIH 3T3 fibroblast and αT3 cell SOCE...
May 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29783653/avian-influenza-virus-subtype-h9n2-affects-intestinal-microbiota-barrier-structure-injury-and-inflammatory-intestinal-disease-in-the-chicken-ileum
#20
Hongxin Li, Xiaolin Liu, Feiyang Chen, Kejing Zuo, Che Wu, Yiming Yan, Weiguo Chen, Wencheng Lin, Qingmei Xie
Avian influenza virus subtype H9N2 (H9N2 AIV) has caused significant losses to the poultry industry due to the high mortality associated with secondary infections attributable to E. coli . This study tries to address the underlying secondary mechanisms after H9N2 AIV infection. Initially, nine day-old specific pathogen-free chickens were assigned to control (uninfected) and H9N2-infected groups, respectively. Using Illumina sequencing, histological examination, and quantitative real-time PCR, it was found that H9N2 AIV caused intestinal microbiota disorder, injury, and inflammatory damage to the intestinal mucosa...
May 18, 2018: Viruses
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