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https://www.readbyqxmd.com/read/28454478/enhanced-mri-t-2-relaxivity-in-contrast-probed-anchor-free-pegylated-iron-oxide-nanoparticles
#1
Bibek Thapa, Daysi Diaz-Diestra, Juan Beltran-Huarac, Brad R Weiner, Gerardo Morell
Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through a dipole-cation covalent interaction. Anchor-free PEG-SPIONs exhibit a spin-spin relaxivity of 123 ± 6 mM(-1)s(-1), which is higher than those of PEG-SPIONs anchored with intermediate biomolecules, iron oxide nanoworms, or Feridex...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454351/the-role-of-quercetin-and-vitamin-c-in-nrf2-dependent-oxidative-stress-production-in-breast-cancer-cells
#2
Zohreh Mostafavi-Pour, Fatemeh Ramezani, Fatemeh Keshavarzi, Nasser Samadi
The balance between the production and elimination of reactive oxygen species (ROS) is essential in determining whether cells survive or undergo apoptosis. Nuclear factor erythroid 2-related factor 2 (Nrf2) may act as a sensor for electrophilic stress, thus regulating the intracellular antioxidant response. The present study investigated the role of vitamin C (VC) and quercetin (Q) in the induction of Nrf2-mediated oxidative stress in cancer cells. An MTT assay was conducted to examine the anti-proliferative effects of VC and Q...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454172/are-optical-fibers-really-uniform-measurement-of-refractive-index-on-a-centimeter-scale
#3
Sébastien Loranger, Raman Kashyap
Many applications of optical fiber, such as specialized fiber Bragg gratings (FBGs), require high uniformity of a fiber's refractive index (RI) along its length. We show here that the mode effective index of most fibers is not constant, even on a short length scale. To help improve fiber manufacturing and selection, we demonstrate a technique for characterizing a meter length single-mode optical fiber's effective RI over a centimeter scale with a precision of 3×10<sup>-6</sup> RI units (RIUs) and an absolute accuracy of 2×10<sup>-4</sup> RIU...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454146/snr-enhancement-in-high-resolution-phase-sensitive-otdr-systems-using-chirped-pulse-amplification-concepts
#4
Juan Pastor-Graells, Luis Romero Cortés, María R Fernández-Ruiz, Hugo F Martins, José Azaña, Sonia Martin-Lopez, Miguel Gonzalez-Herraez
Phase-sensitive optical time-domain reflectometry (φOTDR) is widely used for the distributed detection of mechanical or environmental variations with resolutions of typically a few meters. The spatial resolution of these distributed sensors is related to the temporal width of the input probe pulses. However, the input pulse width cannot be arbitrarily reduced (to improve the resolution), since a minimum pulse energy is required to achieve a good level of signal-to-noise ratio (SNR), and the pulse peak power is limited by the advent of nonlinear effects...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454141/incoherent-optical-modulation-of-graphene-based-on-an-in-line-fiber-mach-zehnder-interferometer
#5
Cong Gao, Lei Gao, Tao Zhu, Guolu Yin
We investigated the incoherent optical modulation of graphene based on an in-line fiber Mach-Zehnder interferometer fabricated by offset splicing of a D-shaped fiber and single-mode fibers. The D-shaped flat surface was coated with a single-layer graphene whose refractive index can be modulated by an external laser. With a backward pump-probe setup, we found that the incoherent optical modulation occurred independently of the wavelength difference between the pump and probe lasers, supporting the theoretical analysis that the incoherent optical modulation is mainly contributed by the carrier-phonon process of graphene...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454138/programmable-single-pixel-based-broadband-stimulated-raman-scattering
#6
Pascal Berto, Camille Scotté, Frédéric Galland, Hervè Rigneault, Hilton B de Aguiar
We report a simple add-on for broadband stimulated Raman scattering (SRS) microscopes to enable fast and programmable spectroscopy acquisition. It comprises a conventional dispersive spectrometer layout incorporating a fast digital micromirror device (DMD). The approach is validated by acquiring SRS spectra of standard chemicals. We demonstrate a DMD's advantage in broadband SRS by showing higher signal-to-noise ratio using a multiplexed Hadamard spectral basis and compressive sensing detection. Our results apply to a variety of frequency-domain pump-probe spectroscopy...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454072/fluorescent-coumarin-based-probe-for-cysteine-and-homocysteine-with-live-cell-application
#7
Ling-Fang Wei, Natesan Thirumalaivasan, Yu-Cheng Liao, Shu-Pao Wu
Cysteine (Cys) and homocysteine (Hcy) are two of important biological thiols and function as important roles in several biological processes. The development of Cys and Hcy probes will help to explore the functions of biothiols in biological systems. In this work, a new coumarin-based probe AC, containing an acryloyl moiety, was developed for Cys and Hcy detection in cells. Cys and Hcy undergo a nucleophilic addition and subsequent cyclization reaction to remove to the acryloyl group and yield a fluorescent product, 7-hydroxylcomuarin...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28454066/direct-measurement-of-igm-antigen-interaction-energy-on-individual-red-blood-cells
#8
Natasha Yeow, Rico F Tabor, Gil Garnier
Most blood grouping tests rely on the principle of red blood cells (RBCs) agglutination. Agglutination is triggered by the binding of specific blood grouping antibodies to the corresponding RBC surface antigen on multiple cells. The interaction energies between blood grouping antibodies and antigens have been poorly defined in immunohaematology. Here for the first time, we functionalized atomic force microscope (AFM) cantilevers with the IgM form of blood grouping antibodies to probe populations of individual RBCs of different groups under physiological conditions...
April 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28454059/outcome-focused-judgements-of-moral-dilemmas-in-schizophrenia
#9
Jonathan McGuire, Martin Brüne, Robyn Langdon
Previous research on moral judgement in healthy adults suggests a complex interplay of automatic, emotional and deliberative processing. We aimed to advance understanding of these processes by examining moral judgement in individuals with schizophrenia, a population characterised by social-cognitive deficits and interpersonal difficulties. Forty-five patients with schizophrenia and 27 healthy controls judged high-conflict moral dilemmas in response to 3rd-person (i.e. "Is it morally okay to [perform X]?") and 1st-person (i...
April 25, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28454057/application-of-2d-nmr-with-room-temperature-nmr-probes-for-the-assessment-of-the-higher-order-structure-of-filgrastim
#10
Robert G Brinson, Houman Ghasriani, Derek J Hodgson, Kristie M Adams, Ian McEwen, Darón I Freedberg, Kang Chen, David A Keire, Yves Aubin, John P Marino
The higher order structure (HOS) of biotherapeutics is a critical quality attribute that can be evaluated by nuclear magnetic resonance (NMR) spectroscopy at atomic resolution. NMR spectral mapping of HOS can be used to establish HOS consistency of a biologic across manufacturing changes or to compare a biosimilar to an innovator reference product. A previous inter-laboratory study performed using filgrastim drug products demonstrated that two-dimensional (2D)-NMR (1)H(N)-(15)N(H) heteronuclear correlation spectroscopy is a highly robust and precise method for mapping the HOS of biologic drugs at natural abundance using high sensitivity NMR 'cold probes...
April 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28454043/vacuum-scanning-capillary-photoemission-microscopy
#11
S A Aseyev, A P Cherkun, B N Mironov, V V Petrunin, S V Chekalin
We demonstrate the use of a conical capillary in a scanning probe microscopy for surface analysis. The probe can measure photoemission from a substrate by transmitting photoelectrons along the capillary as a function of probe position. The technique is demonstrated on a model substrate consisting of a gold reflecting layer on a compact disc which has been illuminated by an unfocused laser beam with a wavelength 400nm, from a femtosecond laser with a beam size of 4mm. A quartz capillary with a 2-µm aperture has been used in the experiments...
April 19, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28454038/long-term-variations-measurement-of-electromagnetic-field-exposures-in-alcal%C3%A3-de-henares-spain
#12
R Sánchez-Montero, C Alén-Cordero, P L López-Espí, J M Rigelsford, F Aguilera-Benavente, J Alpuente-Hermosilla
Electromagnetic radiowave exposure is a major concern in most countries due to possible adverse health effects. Over the last 10years, many technological changes (digital television, mobile technologies, wireless networks…) have led to variations in the electromagnetic field (EMF) levels. A large number of studies devoted to the analysis of EMF levels with personal dosimeters or computer models of the exposure of mobile stations have been conducted. However, the study of the exposure values, taking into account all the existing sources, and their evolution in a wide area, using measurements, has rarely been performed...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28453941/probing-molecular-interactions-between-human-carbonic-anhydrases-hcas-and-a-novel-class-of-benzenesulfonamides
#13
Elvira Bruno, Maria Rosa Buemi, Anna Di Fiore, Laura De Luca, Stefania Ferro, Andrea Angeli, Roberto Cirilli, Daniele Sadutto, Vincenzo Alterio, Simona Maria Monti, Claudiu T Supuran, Giuseppina De Simone, Rosaria Gitto
On the basis of X-ray crystallographic studies of the complex of hCA II with 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)benzenesulfonamide (3) (PDB code 4Z1J), a novel series of 4-(1-aryl-3,4-dihydro-1H-isoquinolin-2-carbonyl)benzenesulfonamides (23-33) was designed. Specifically, our idea was to improve the selectivity toward druggable isoforms through the introduction of additional hydrophobic/hydrophilic functionalities. Among the synthesized and tested compounds, the (R,S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide (30) exhibited a remarkable inhibition for the brain-expressed hCA VII (Ki = 0...
April 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28453932/a-green-route-to-a-na2fepo4f-based-cathode-for-sodium-ion-batteries-of-high-rate-and-long-cycling-life
#14
Xiang Deng, Wenxiang Shi, Jaka Sunarso, Meilin Liu, Zongping Shao
Sodium-ion batteries (SIBs) are considered one of the most promising alternatives for large-scale energy storage due largely to the abundance and low cost of sodium. However, the lack of high-performance cathode materials at low cost represents a major obstacle towards broad commercialization of SIB technology. In this work, we report a green route strategy that allows cost-effective fabricaiton of carbon-coated Na2FePO4F cathode for SIBs. By using vitamin C as a green organic carbon source and environment-friendly water-based polyacrylic latex as the binder, we have demonstrated that the Na2FePO4F phase in the as-derived Na2FePO4F/C electrode shows a high reversible capacity of 117 mAh g-1 at a cycling rate of 0...
April 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28453927/tir-domain-containing-adapter-inducing-interferon-%C3%AE-trif-forms-filamentous-structures-whose-pro-apoptotic-signalling-is-terminated-by-autophagy
#15
I E Gentle, K T McHenry, A Weber, A Metz, O Kretz, D Porter, G Häcker
The formation of amyloid-like protein structures has recently emerged as a feature in signal transduction, particularly in innate immunity. These structures appear to depend on defined domains for their formation but likely also require dedicated ways to terminate signalling. We here define the innate immunity protein/Toll-like receptor adaptor TRIF as a novel platform of fibril formation and probe signal initiation through TRIF as well as its termination in toll-like receptor 3 (TLR3)-stimulated melanoma cells...
April 28, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28453890/less-is-more-patient-level-meta-analysis-reveals-paradoxical-dose-response-effects-of-a-computer-based-social-anxiety-intervention-targeting-attentional-bias
#16
REVIEW
Rebecca B Price, Jennie M Kuckertz, Nader Amir, Yair Bar-Haim, Per Carlbring, Meredith L Wallace
BACKGROUND: The past decade of research has seen considerable interest in computer-based approaches designed to directly target cognitive mechanisms of anxiety, such as attention bias modification (ABM). METHODS: By pooling patient-level datasets from randomized controlled trials of ABM that utilized a dot-probe training procedure, we assessed the impact of training "dose" on relevant outcomes among a pooled sample of 693 socially anxious adults. RESULTS: A paradoxical effect of the number of training trials administered was observed for both posttraining social anxiety symptoms and behavioral attentional bias (AB) toward threat (the target mechanism of ABM)...
April 28, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28453869/nonsurgical-treatment-of-peri-implant-mucositis-and-peri-implantitis-at-two-piece-zirconium-implants-a-clinical-follow-up-observation-after-up-to-3-years
#17
G John, J Becker, A Schmucker, F Schwarz
OBJECTIVES: To assess the long-term clinical outcomes following nonsurgical therapy of peri-implant diseases at two-piece zirconium implants. MATERIAL & METHODS: A total of 27 patients suffering from either (i) peri-implant mucositis (n=24 implants) or (ii) peri-implantitis (n=16 implants) completed a mean follow-up period of 32.8±2.85 months (median: 34 months). The initial treatment procedures included (i) mechanical debridement + local antiseptic therapy using chlorhexidine digluconate (MD+CXH), or (ii) Er:YAG laser monotherapy (ERL)...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453865/saliva-and-plasma-levels-of-cardiac-related-biomarkers-in-post-myocardial-infarction-patients
#18
N Rathnayake, K Buhlin, B Kjellström, B Klinge, C Löwbeer, A Norhammar, L Rydén, T Sorsa, T Tervahartiala, A Gustafsson
AIM: To relate cardiac biomarkers, such as Cystatin C and Growth differentiation factor-15 (GDF-15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. MATERIALS AND METHODS: 200 patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453850/a-novel-ligand-of-toll-like-receptor-4-from-the-sheath-of-wuchereria-bancrofti-microfilaria-induces-proinflammatory-response-in-macrophages
#19
Suprabhat Mukherjee, Sandip Mukherjee, Tushar K Maiti, Samir Bhattacharya, Santi P Sinha Babu
Background.: Lymphatic filariasis, frequently caused from Wuchereria bancrofti infection, is endemic in several parts of the globe and responsible for human health problems and socioeconomic loss to a large extent. Inflammatory consequences originating from host-parasite interaction play a major role in the disease pathology and allied complications. The identity of the key mediator of this process is yet unknown in filarial research. Methods.: Microfilarial protein (MfP) was isolated from the sheath of W...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28453818/downstream-element-determines-rnase-y-cleavage-of-the-saepqrs-operon-in-staphylococcus-aureus
#20
Gabriella Marincola, Christiane Wolz
In gram-positive bacteria, RNase J1, RNase J2 and RNase Y are thought to be major contributors to mRNA degradation and maturation. In Staphylococcus aureus, RNase Y activity is restricted to regulating the mRNA decay of only certain transcripts. Here the saePQRS operon was used as a model to analyze RNase Y specificity in living cells. A RNase Y cleavage site is located in an intergenic region between saeP and saeQ. This cleavage resulted in rapid degradation of the upstream fragment and stabilization of the downstream fragment...
April 27, 2017: Nucleic Acids Research
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