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https://www.readbyqxmd.com/read/29668140/-standardization-of-a-multiplex-real-time-pcr-test-for-the-identification-of-angiostrongylus-cantonensis-a-costaricensis-and-a-vasorum
#1
Rubén E Varela-M, Jinney Stefany Arias, Luz Elena Velásquez
INTRODUCTION: Angiostrongyliasis is a disease caused by Angiostrongylus nematodes that is present worldwide. The infections with the highest impact on human and animal health are caused by A. cantonensis, A. costaricensis, and A. vasorum. Clinical forms of the disease in humans are eosinophilic meningitis and abdominal angiostrongyliasis, while the most common effect on dogs are cardiopulmonary damages. It is deemed as an emerging disease as the result of the global dissemination of the African snail Lissachatina fulica, an intermediary host of these parasites...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668002/a-sharp-edge-based-acoustofluidic-chemical-signal-generator
#2
Po-Hsun Huang, Chung Yu Chan, Peng Li, Yuqi Wang, Nitesh Nama, Hunter Bachman, Tony Jun Huang
Resolving the temporal dynamics of cell signaling pathways is essential for regulating numerous downstream functions, from gene expression to cellular responses. Mapping these signaling pathways requires the exposure of cells to time-varying chemical signals; these are difficult to generate and control over a wide temporal range. Herein, we present an acoustofluidic chemical signal generator based on a sharp-edge-based micromixing strategy. The device, simply by modulating the driving signals of an acoustic transducer including the ON/OFF switching frequency, actuation time and duty cycle, is capable of generating both single-pulse and periodic chemical signals that are temporally controllable in terms of stimulation period, stimulation duration and duty cycle...
April 18, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29667932/fused-data-transrectal-eit-for-prostate-cancer-imaging
#3
Ethan K Murphy, Xiaotian Wu, Ryan J Halter
OBJECTIVE: Prostate cancer is a significant problem affecting 1 in 7 men. Unfortunately, the diagnostic gold-standard of ultrasound-guided biopsy misses 10-30% of all cancers. The objective of this study was to develop an Electrical Impedance Tomography (EIT) approach that has the potential to image the entire prostate using multiple impedance measurements recorded between electrodes integrated onto an end-fired transrectal ultrasound (TRUS) device and a biopsy probe (BP). APPROACH: Simulations and sensitivity analyses were used to investigate the best combination of electrodes, and measured tank experiments were used to evaluate a fused-data transrectal EIT (fd-TREIT) and BP approach...
April 18, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29667813/a-sensitive-water-soluble-reversible-optical-probe-for-hg-2-detection
#4
Sayani Das, Anindita Sarkar, Ananya Rakshit, Ankona Datta
We report the serendipitous discovery of an optical mercury sensor while trying to develop a water-soluble manganese probe. The sensor is based on a pentaaza macrocycle conjugated to a hemicyanine dye. The pentaaza macrocycle earlier designed in our group was used to develop photoinduced electron transfer (PET)-based "turn-on" fluorescent sensors for manganese. (1) In an attempt to increase the water-solubility of the manganese sensors we changed the dye from BODIPY to hemicyanine. The resultant molecule qHCM afforded a distinct reversible change in the absorption features and a concomitant visible color change upon binding to Hg2+ ions, leading to a highly water-soluble mercury sensor with a 10 ppb detection limit...
April 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29667809/strand-displacement-probes-combined-with-isothermal-nucleic-acid-amplification-for-instrument-free-detection-from-complex-samples
#5
Elizabeth A Phillips, Taylor J Moehling, Sanchita Bhadra, Andrew D Ellington, Jacqueline C Linnes
Sensitive and specific detection of pathogens via nucleic acid amplification is currently constrained to laboratory settings and portable equipment with costly fluorescent detectors. Nucleic acid-detecting lateral flow immunoassay strips (LFIAs) offer a low-cost visual transduction strategy at points of need. Unfortunately, these LFIAs frequently detect amplification byproducts that can yield spurious results which can only be deciphered through statistical analysis. We integrated customizable strand displacement probes into standard loop mediated isothermal amplification (LAMP) assays to prevent byproduct capture on commercial LFIAs...
April 18, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29667743/a-combined-25mg-solid-state-nmr-and-ab-initio-dft-approach-to-probe-the-local-structural-differences-in-magnesium-acetate-phases-mg-ch3coo-2-nh2o-n-0-1-4
#6
Valerie Seymour, Stephen Day, Gudrun Scholz, Kerstin Scheurell, Dinu Iuga, John Griffin, Erhard Kemnitz, John Hanna, Mark E Smith
Multinuclear (1H, 13C, 25Mg) solid-state NMR data is reported for a series of magnesium acetate phases Mg(CH3COO)2.nH2O (n = 0 (two polymorphs), 1, 4). The central focus here is 25Mg as this set of compounds provides an expanded range of local magnesium coordinations compared to what has previously been reported in the literature using NMR. These four compounds provide 10 distinct magnesium sites with varying NMR interaction parameters. One of the anhydrous crystal structures (α) has an MgO7 site which is reported, to the best of our knowledge, for the first time...
April 18, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29667686/rheological-characterization-of-dynamic-remodeling-of-the-pericellular-region-by-human-mesenchymal-stem-cell-secreted-enzymes-in-well-defined-synthetic-hydrogel-scaffolds
#7
Maryam Daviran, Sarah M Longwill, Jonah F Casella, Kelly M Schultz
Human mesenchymal stem cells (hMSCs) dynamically remodel their microenvironment during basic processes, such as migration and differentiation. Migration requires extracellular matrix invasion, necessitating dynamic cell-material interactions. Understanding these interactions is critical to advancing materials designs that harness and manipulate these processes for applications including wound healing and tissue regeneration. In this work, we encapsulate hMSCs in a cell-degradable poly(ethylene glycol)-peptide hydrogel to determine how cell-secreted enzymes, specifically matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), create unique pericellular microenvironments...
April 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29667670/two-dimensional-transition-metal-carbides-and-nitrides-mxenes-for-biomedical-applications
#8
Kai Huang, Zhongjun Li, Jing Lin, Gang Han, Peng Huang
Two-dimensional transition metal carbides and nitrides known as MXenes, with a general formula of Mn+1Xn (n = 1-3), integrate the advantages of metallic conductive transition metals with large groups of carbides, nitrides, or carbonitrides. They have led to a burgeoning research interest in biomedical applications due to their ultrathin structure and fascinating physiochemical (electronic, optical, magnetic, etc.) properties. In this review, we summarize recent advances in biomedical applications for MXenes...
April 18, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29667601/probing-ionization-potential-electron-affinity-and-self-energy-effect-on-the-spectral-shape-and-exciton-binding-energy-of-quantum-liquid-water-with-self-consistent-many-body-perturbation-theory-and-bethe-salpeter-equation
#9
Vafa Ziaei, Thomas Bredow
An accurate theoretical prediction of ionization potential (IP) and electron
 affinity (EA) is key for understanding of complex photochemical processes in
 aqueous environments. There have been numerous efforts in literature to
 accurately predict IP and EA of liquid water, however with often
 conflicting results depending on the level of theory and the underlying water
 structures. In a recent study based on hybrid-non-self-consistent many-body
 perturbation theory (MBPT)
 Gaiduk et al...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667536/simulation-of-protein-diffusion-a-sensitive-probe-of-protein-solvent-interactions
#10
Valerio Ferrario, Jürgen Pleiss
Aqueous solutions of Candida antarctica lipase B (CALB) were simulated considering three different water models (SPC/E, TIP3P, TIP4P) by a series of molecular dynamics (MD) simulations of three different box sizes (L = 9, 14, and 19 nm) to determine the diffusion coefficient, the water viscosity, and the protein density. The protein-water systems were equilibrated for 500 ns, followed by 100 ns production runs which were analyzed. The diffusional properties of CALB were characterized by the Stokes radius (RS ), which was derived from the diffusion coefficient and the viscosity...
April 18, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29667525/the-association-between-bronchial-asthma-and-periodontitis-a-case-control-study-in-jordan
#11
Basheer Khassawneha, Rola Alhabashnehb, Fadi Ibrahimc
OBJECTIVE: Our aim is to study the association between bronchial asthma (BA) and periodontitis in northern Jordan. METHODS: A case-control study of 260 subjects; 130 with BA and 130 without BA (controls) were recruited from pulmonary clinics at a university hospital in northern Jordan. BA was physician diagnosed and on anti-asthma medications for ≥12 months. Periodontitis was defined as the presence of ≥ 4 teeth with ≥ 1 site with probing pocket depth (PPD) ≥ 4 mm and clinical attachment level (CAL) ≥ 3 mm...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29667366/divergent-effects-of-healthy-ageing-on-semantic-knowledge-and-control-evidence-from-novel-comparisons-with-semantically-impaired-patients
#12
Paul Hoffman
Effective use of semantic knowledge requires a set of conceptual representations and control processes which ensure that currently relevant aspects of this knowledge are retrieved and selected. It is well-established that levels of semantic knowledge increase across the lifespan. However, the effects of ageing on semantic control processes have not been assessed. I addressed this issue by comparing the performance profiles of young and older people on a verbal comprehension test. Two sets of variables were used to predict accuracy and RT in each group: (1) the psycholinguistic properties of words probed in each trial and (2) the performance on each trial by two groups of semantically impaired neuropsychological patients...
April 17, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29667306/carbon-and-nitrogen-based-nanosheets-as-fluorescent-probes-with-tunable-emission
#13
Jingwen Sun, Ravit Malishev, Adi Azoulay, Jonathan Tzadikov, Michael Volokh, Raz Jelinek, Menny Shalom
2D carbon and nitrogen based semiconductors (CN) have attracted widespread attention for their possible use as low-cost and environmentally friendly materials for various applications. However, their limited solution-dispersibility and the difficulty in preparing exfoliated sheets with tunable photophysical properties restrain their exploitation in imaging-related applications. Here, the synthesis of carbon and nitrogen organic scaffolds with highly tunable optical properties, excellent dispersion in water and DMSO, and good bioimaging properties is reported...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667250/a-new-2d-echocardiographic-approach-to-evaluate-the-membrane-and-valve-movement-of-the-berlin-heart-excor-vad-chamber-in-pediatric-vad-patients
#14
Arianna Di Molfetta, Roberta Iacobelli, Gianfranco Ferrari, Sergio Filippelli, Gianluigi Perri, Alessandra Toscano, Rachele Adorisio, Paolo Guccione, Antonio Amodeo
The use of Berlin Heart EXCOR VAD (BH) is a validated therapy to bridge pediatric patients to heart transplant. Serial echocardiographic (ECHO) assessment of VAD patients is necessary to support patients' management. This work aims at developing an innovative strategy to evaluate the BH device functioning by ECHO and its interaction with the native heart in a pediatric population. ECHO evaluation of BH membrane movement, and inflow and outflow valves was performed in 2D, 2D-color Doppler, M-mode, and M-mode color Doppler to assess the functioning of the device by direct positioning of the ECHO probe on the BH cannulas and membranes...
April 2018: Artificial Organs
https://www.readbyqxmd.com/read/29667241/large-enhancement-of-2d-electron-gases-mobility-induced-by-interfacial-localized-electron-screening-effect
#15
Xiao Chi, Zhen Huang, Teguh C Asmara, Kun Han, Xinmao Yin, Xiaojiang Yu, Caozheng Diao, Ming Yang, Daniel Schmidt, Ping Yang, Paolo E Trevisanutto, T J Whitcher, T Venkatesan, Mark B H Breese, Ariando, Andrivo Rusydi
The interactions between delocalized and localized charges play important roles in correlated electron systems. Here, using a combination of transport measurements, spectroscopic ellipsometry (SE), and X-ray absorption spectroscopy (XAS) supported by theoretical calculations, we reveal the important role of interfacial localized charges and their screening effects in determining the mobility of (La0.3 Sr0.7 )(Al0.65 Ta0.35 )O3 /SrTiO3 (LSAT/SrTiO3 ) interfaces. When the LSAT layer thickness reaches the critical value of 5 uc, the insulating interface abruptly becomes conducting, accompanied by the appearance of a new midgap state...
April 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29667226/probing-long-range-spin-spin-coupling-constants-in-2-halo-substituted-cyclohexanones-and-cyclohexanethiones-the-role-of-solvent-and-stereoelectronic-effects
#16
Fátima M P de Rezende, Matheus P Freitas, Teodorico C Ramalho
Earlier studies with 2-bromocyclohexanone demonstrated a measurable long-range coupling constant (4 JH2,H6 ) for the equatorial conformer, while 4 JH2,H4 and 4 JH4,H6 were not observed; as a consequence, it is inferred that the carbonyl group plays an important role particularly due to hyperconjugative interactions σC2H2 →π*C=O and σC6H6 →π*C=O. In the present study, NBO analysis and coupling constant calculations were performed to cyclohexanone and cyclohexanethione alpha substituted with F, Cl and Br, aiming to evaluate the halogen effect and acceptor character of the π* orbital on the long-range coupling pathway...
April 17, 2018: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29667001/c-phycoerythrin-as-a-colorimetric-and-fluorometric-probe-for-the-sensitive-selective-and-quantitative-detection-of-cu-2-in-aqueous-samples
#17
Tonmoy Ghosh, Apeksha Vyas, Khushbu Bhayani, Sandhya Mishra
C-phycoerythrin (CPE) was investigated as a colorimetric and fluorometric quantitative sensor for Cu2+ ions in an aqueous medium. UV - visible studies with 50 μM concentration of different metals were carried out with only Cu and Ag showing changes in the absorption spectra. Fluorescence emission studies showed similar results. UV - visible titration of CPE with different [Cu] resulted in a linear relationship within 10 μM Cu and a 'naked eye' visible difference in colour, most likely due to the formation of a CPE - Cu complex...
April 18, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29666907/three-dimensional-analysis-of-nuclear-heterochromatin-distribution-during-early-development-in-the-rabbit
#18
Amélie Bonnet-Garnier, Kiên Kiêu, Tiphaine Aguirre-Lavin, Krisztina Tar, Pierre Flores, Zichuan Liu, Nathalie Peynot, Martine Chebrout, András Dinnyés, Véronique Duranthon, Nathalie Beaujean
Changes to the spatial organization of specific chromatin domains such as constitutive heterochromatin have been studied extensively in somatic cells. During early embryonic development, drastic epigenetic reprogramming of both the maternal and paternal genomes, followed by chromatin remodeling at the time of embryonic genome activation (EGA), have been observed in the mouse. Very few studies have been performed in other mammalian species (human, bovine, or rabbit) and the data are far from complete. During this work, we studied the three-dimensional organization of pericentromeric regions during the preimplantation period in the rabbit using specific techniques (3D-FISH) and tools (semi-automated image analysis)...
April 18, 2018: Chromosoma
https://www.readbyqxmd.com/read/29666868/in-vitro-antibacterial-activity-of-oxide-and-non-oxide-bioceramics-for-arthroplastic-devices-ii-fourier-transform-infrared-spectroscopy
#19
Francesco Boschetto, Nami Toyama, Satoshi Horiguchi, Ryan M Bock, Bryan J McEntire, Tetsuya Adachi, Elia Marin, Wenliang Zhu, Osam Mazda, B Sonny Bal, Giuseppe Pezzotti
The metabolic response of Gram-positive Staphylococcus epidermidis (S. epidermidis) bacteria to bioceramic substrates was probed by means of Fourier transform infrared spectroscopy (FTIR). Oxide zirconia-toughened alumina (ZTA) and non-oxide silicon nitride (Si3N4) substrates were tested. Bacteria exposed to silica glass substrates were used as a control. S. epidermidis, a major cause of periprosthetic infections, was screened to obtain a precise time-lapse knowledge of its molecular composition and to mechanistically understand its interaction with different substrates...
April 18, 2018: Analyst
https://www.readbyqxmd.com/read/29666865/preparation-of-lactic-acid-and-glucose-responsive-poly-%C3%AE%C2%B5-caprolactone-b-poly-ethylene-oxide-block-copolymer-micelles-using-phenylboronic-ester-as-a-sensitive-block-linkage
#20
David Vrbata, Mariusz Uchman
The present study describes the synthesis, self-assembly and responsiveness to glucose and lactic acid of biocompatible and biodegradable block copolymer micelles using phenylboronic ester as the linkage between hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene oxide) (PEO). The PCL block with pendant phenylboronic acid (PCLBA) was synthesized by combining ε-caprolactone (ε-CL) ring-opening polymerisation (ROP), using 4-hydroxymethyl(phenylboronic) acid pinacolate as the initiator, and pinacol deprotection...
April 18, 2018: Nanoscale
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