Junyu Lin, Chunyu Li, Ruwei Ou, Yanbing Hou, Lingyu Zhang, Qianqian Wei, Kuncheng Liu, Qirui Jiang, Tianmi Yang, Yi Xiao, Dejiang Pang, Yujiao Yu, Wei Song, Bi Zhao, Xueping Chen, Jing Yang, Ying Wu, Huifang Shang
BACKGROUND: Excessive daytime sleepiness (EDS) is one of the most frequent non-motor symptoms in Parkinson's disease (PD); however, the pathogenesis of EDS is unclear, and there is a lack of information on plasma biomarkers for EDS in PD. We aimed to investigate the plasma biomarkers of EDS in a large PD cohort. METHODS: A total of 159 PD patients were included in the prospective cohort study and followed up annually for three years. Plasma biomarkers including glial fibrillary acidic protein, amyloid-beta, p-tau181, and neurofilament light chain (NfL), were measured using an ultrasensitive single-molecule array (SimoaTM) technology at each visit...
March 25, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences