keyword
MENU ▼
Read by QxMD icon Read
search

Non-motor symptoms

keyword
https://www.readbyqxmd.com/read/29054917/longitudinal-diffusion-imaging-across-the-c9orf72-clinical-spectrum
#1
Mary Kay Floeter, Laura E Danielian, Laura E Braun, Tianxia Wu
INTRODUCTION: Discrepancies between diffusion tensor imaging (DTI) findings and functional rating scales in amyotrophic lateral sclerosis (ALS) may be due to symptom heterogeneity, particularly coexisting cognitive-behavioural dysfunction affecting non-motor regions of the brain. Carriers of expansion mutations in the C9orf72 gene, whose motor and cognitive-behavioural symptoms span a range from ALS to frontotemporal dementia, present an opportunity to evaluate the relationship between symptom heterogeneity and DTI changes...
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29054329/the-optimal-stimulation-site-for-high-frequency-repetitive-transcranial-magnetic-stimulation-in-parkinson-s-disease-a-double-blind-crossover-pilot-study
#2
Masaru Yokoe, Tomoo Mano, Tomoyuki Maruo, Koichi Hosomi, Toshio Shimokawa, Haruhiko Kishima, Satoru Oshino, Shayne Morris, Yu Kageyama, Yuko Goto, Takeshi Shimizu, Hideki Mochizuki, Toshiki Yoshimine, Youichi Saitoh
Many reports have shown improvements in motor symptoms after repetitive transcranial magnetic stimulation (rTMS). However, the best stimulation area in the brain has not currently been determined. We assessed the effects of high-frequency rTMS (HF-rTMS) on the motor and mood disturbances in Parkinson's disease (PD) patients and attempted to determine whether the primary motor area (M1), the supplementary motor area (SMA), and the dorsolateral prefrontal cortex (DLPFC) were the best treatment targets. In this randomized, double-blind crossover design study, we investigated the efficacy of 3 consecutive days of HF-rTMS over the M1, SMA, and DLPFC and compared these HF-rTMS to sham stimulations...
October 17, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29053115/-syndrome-of-rapid-eye-movement-sleep-behavior-disorder-and-nocturia-in-parkinson-s-disease
#3
M R Nodel, Yu V Ukraintseva, N N Yakhno
AIM: Parasomnia, a syndrome of rapid eye movement sleep behavior disorder (RBD), is a common non-motor impairment in patients with Parkinson's disease (PD). The relationship between RBD with other symptoms of PD affecting night sleep, in particular, nocturia, is understudied. An aim of the study was to determine the symptoms related to night sleep disturbances in PD patients with RBD and assess the dynamics of these disturbances with the disease progression taking into account RBD onset...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29051842/is-there-a-premotor-phase-of-essential-tremor
#4
REVIEW
Abhishek Lenka, Julian Benito-León, Elan D Louis
BACKGROUND: Essential tremor (ET) is the most common tremor disorder. In addition to its hallmark feature, kinetic tremor of the upper limbs, patients may have a number of non-motor symptoms and signs (NMS). Several lines of evidence suggest that ET is a neurodegenerative disorder and certain NMS may antedate the onset of tremor. This article comprehensively reviews the evidence for the existence of a "premotor phase" of ET, and discusses plausible biological explanations and implications...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29043468/cognitive-and-behavioral-disorders-in-parkinson-s-disease-an-update-i-cognitive-impairments
#5
Costanza Papagno, Luigi Trojano
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by motor symptoms such as rigidity, rest tremor, and bradykinesia. However, a growing body of evidence demonstrated that PD encompasses several non-motor disturbances as well, such as cognitive impairment. Cognitive defects can be present since early stages of the disease but tend to dominate the clinical picture as the disease progresses. Around 40% of patients with PD present with cognitive impairments in several cognitive domains including attention, working memory and executive functions, language, visuospatial skills, and episodic memory; in later stages of the disease, cognitive defects and associated behavioral disorders concur to determine clinically relevant PD-associated dementia...
October 17, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29037500/motor-behavioural-and-cognitive-correlates-of-fatigue-in-early-de-novo-parkinson-disease-patients
#6
M Siciliano, L Trojano, R De Micco, A De Mase, F Garramone, A Russo, G Tedeschi, A Tessitore
INTRODUCTION: Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS: Eighty-one consecutive de novo PD patients (64% men; mean age 65.73 ± 8.26 years) underwent a comprehensive examination, including Parkinson's disease Fatigue Scale (PFS), Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Beck Depression Inventory (BDI), Parkinson's Anxiety Scale (PAS), and Apathy Evaluation Scale (AES)...
October 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29037499/neuropsychiatric-and-cognitive-profile-of-early-richardson-s-syndrome-progressive-supranuclear-palsy-parkinsonism-and-parkinson-s-disease
#7
Clelia Pellicano, Francesca Assogna, Nystya Cellupica, Federica Piras, Mariangela Pierantozzi, Alessandro Stefani, Rocco Cerroni, Bruno Mercuri, Carlo Caltagirone, Francesco E Pontieri, Gianfranco Spalletta
INTRODUCTION: The two main variants of Progressive Supranuclear Palsy (PSP), Richardson's syndrome (PSP-RS) and PSP-parkinsonism (PSP-P), share motor and non-motor features with Parkinson's disease (PD) particularly in the early stages. This makes the precocious diagnosis more challenging. We aimed at defining qualitative and quantitative differences of neuropsychiatric and neuropsychological profiles between PSP-P, PSP-RS and PD patients recruited within 24 months after the onset of symptoms, in order to clarify if the identification of peculiar cognitive and psychiatric symptoms is of help for early PSP diagnosis...
October 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29037498/levodopa-carbidopa-intestinal-gel-in-advanced-parkinson-s-final-results-of-the-gloria-registry
#8
Angelo Antonini, Werner Poewe, K Ray Chaudhuri, Robert Jech, Barbara Pickut, Zvezdan Pirtošek, Jozsef Szasz, Francesc Valldeoriola, Christian Winkler, Lars Bergmann, Ashley Yegin, Koray Onuk, David Barch, Per Odin
INTRODUCTION: This registry evaluated the 24-month safety and efficacy of levodopa-carbidopa intestinal gel (LCIG) treatment in advanced Parkinson's disease (PD) patients under routine clinical care. METHODS: Motor fluctuations, dyskinesia, non-motor symptoms, quality of life, and safety were evaluated. Observations were fully prospective for treatment-naïve patients (60% of patients) and partially retrospective for patients with ≤12 months of pre-treatment with LCIG (40% of patients)...
September 22, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29037340/-neuropsychiatry-of-movement-disorders
#9
Juan Manuel Orjuela-Rojas, Gustavo Adolfo Barrios Vincos, Melisa Alejandra Martínez Gallego
Movement disorders can be defined as neurological syndromes presenting with excessive or diminished automatic or voluntary movements not related to weakness or spasticity. Both Parkinson's disease (PD) and Huntington's disease (HD) are well-known examples of these syndromes. The high prevalence of comorbid psychiatric symptoms like depression, anxiety, obsessive-compulsive symptoms, hallucinations, delusions, impulsivity, sleep disorders, apathy and cognitive impairment mean that these conditions must be regarded as neuropsychiatric diseases...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29037065/patterns-of-symptom-development-in-patients-with-motor-neuron-disease
#10
Renée Walhout, Esther Verstraete, Martijn P Van Den Heuvel, Jan H Veldink, Leonard H Van Den Berg
OBJECTIVE: To investigate whether symptom development in motor neuron disease (MND) is a random or organized process. METHODS: Six hundred patients with amyotrophic lateral sclerosis (ALS), upper motor neuron (UMN) or lower motor neuron (LMN) phenotypes were invited for a questionnaire concerning symptom development. A binomial test was used to examine distribution of symptoms from site of onset. Development of symptoms over time was evaluated by Kaplan-Meier analysis...
October 16, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29034646/index-of-theta-alpha-ratio-of-the-quantitative-electroencephalogram-in-alzheimer-s-disease-a-case-control-study
#11
Golshan Fahimi, Seyed Mahmoud Tabatabaei, Elnaz Fahimi, Hamid Rajebi
Alzheimer's disease (AD) is a devastating neurodegenerative disorder in human beings associated with cognitive, behavioral and motor impairments. The main symptom of AD is dementia, which causes difficulties in carrying out daily practices. Brain waves are altered in people with AD. Relative indices of brain waves can be beneficial in the diagnosis of AD. In this case-control study, 50 patients with AD and 50 matched healthy individuals were enrolled in case and control groups respectively. With recording and analyzing of brain waves with the utilization of quantitative electroencephalogram (QEEG), index of theta/alpha ratio was assessed in both groups...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29033800/stimulation-of-cortico-subthalamic-projections-amplifies-resting-motor-circuit-activity-and-leads-to-increased-locomotion-in-dopamine-depleted-mice
#12
Teresa H Sanders
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in patients with Parkinson's disease (PD). STN-DBS enables similar improved motor function, including increased movement speed (reduced bradykinesia), in the 6-OHDA dopamine-depletion mouse model of PD. Previous analyses of electrophysiological recordings from STN and motor cortex (M1) have explored signaling changes that correspond to PD and amelioration of PD symptoms. The most common results show an increase in beta frequency power during 'off' states and a reduction in beta during 'on' states...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29032012/continuous-subcutaneous-apomorphine-infusion-in-parkinson-s-disease-patients-with-cognitive-dysfunction-a-retrospective-long-term-follow-up-study
#13
Robbert W K Borgemeester, Teus van Laar
INTRODUCTION: Continuous apomorphine infusion (CAI) is an advanced therapy in fluctuating Parkinson's disease (PD). The use of CAI is controversial in PD patients with cognitive dysfunction including visual hallucinations (VHs), and orthostatic hypotension (OH). This study was set-up to analyze the effectiveness and safety of CAI in elderly PD patients with cognitive dysfunction. METHODS: This new-user cohort study identified fluctuating PD patients who started CAI treatment at the rehabilitation unit of Parkinson Expertise Center (RU-PEC) Groningen, from November 2004 until 2016...
September 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29031008/identification-of-a-novel-homozygous-trappc9-gene-mutation-causing-non-syndromic-intellectual-disability-speech-disorder-and-secondary-microcephaly
#14
Ansar A Abbasi, Kathrin Blaesius, Hao Hu, Zahid Latif, Sylvie Picker-Minh, Muhammad N Khan, Sundas Farooq, Muzammil A Khan, Angela M Kaindl
TRAPPC9 gene mutations have been linked recently to autosomal recessive mental retardation 13 (MRT13; MIM#613192) with only eight families reported world-wide. We assessed patients from two consanguineous pedigrees of Pakistani descent with non-syndromic intellectual disability and postnatal microcephaly through whole exome sequencing (WES) and cosegregation analysis. Here we report six further patients from two pedigrees with homozygous TRAPPC9 gene mutations, the novel nonsense mutation c.2065G>T (p.E689*) and the previously identified nonsense mutation c...
October 14, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29024046/traumatic-brain-injury-in-the-prodromal-period-of-parkinson-disease-a-large-epidemiological-study-using-medicare-data
#15
Alejandra Camacho-Soto, Mark N Warden, Susan Searles Nielsen, Amber Salter, David L Brody, Heidi Prather, Brad A Racette
OBJECTIVE: Studies suggest a greater risk of Parkinson disease (PD) after traumatic brain injury (TBI), but it is possible that the risk of TBI is greater in the prodromal period of PD. We aimed to examine the time-to-TBI in PD patients in their prodromal period compared to population-based controls. METHODS: We identified 89,790 incident PD cases and 118,095 comparable controls > 65 years of age in 2009 using Medicare claims data. Using data from the preceding five years, we compared time-to-TBI in PD patients in their prodromal period to controls...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29021863/brain-magnetic-resonance-imaging-examination-in-a-patient-with-non-magnetic-resonance-conditional-pacemaker
#16
Toshiko Nakai, Toshiaki Sato, Kyoko Soejima, Yusuke Takamine, Mitsuru Watanabe, Kazutaka Kobayashi, Hideki Oshima, Chikashi Fukaya, Yasuo Okumura, Kimie Ohkubo, Satoshi Kunimoto, Ichiro Watanabe, Atsuo Yoshino, Atsushi Hirayama
Clinical dilemmas arise when patients with a non-magnetic resonance (MR) conditional pacemaker are required to undergo magnetic resonance imaging (MRI). We encountered a pacemaker patient with debilitating non-motor symptoms of Parkinson׳s disease, who required an MRI prior to deep brain stimulation (DBS) surgery. MRI was performed safely without adverse events despite the presence of a conventional pacemaker.
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29019056/physical-exercise-modulates-l-dopa-regulated-molecular-pathways-in-the-mptp-mouse-model-of-parkinson-s-disease
#17
Cornelius J H M Klemann, Helena Xicoy, Geert Poelmans, Bas R Bloem, Gerard J M Martens, Jasper E Visser
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc), resulting in motor and non-motor dysfunction. Physical exercise improves these symptoms in PD patients. To explore the molecular mechanisms underlying the beneficial effects of physical exercise, we exposed 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP)-treated mice to a four-week physical exercise regimen, and subsequently explored their motor performance and the transcriptome of multiple PD-linked brain areas...
October 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29016440/the-feature-of-clinical-and-radiographic-outcomes-in-elderly-patients-with-cervical-spondylotic-myelopathy-a-prospective-cohort-study-on-1025-patients
#18
Masaaki Machino, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Kenyu Ito, Mikito Tsushima, Akiyuki Matsumoto, Masayoshi Morozumi, Satoshi Tanaka, Keigo Ito, Fumihiko Kato, Yoshihiro Nishida, Naoki Ishiguro
STUDY DESIGN: A prospective cohort study OBJECTIVE.: The purpose of this study was to compare the surgical outcomes between non-elderly and elderly patients with cervical spondylotic myelopathy (CSM) and to characterize the preoperative symptoms and postoperative residual symptoms in elderly patients. SUMMARY OF BACKGROUND DATA: Age at the time of surgery influences the surgical outcome. However, no report has elucidated residual symptoms following surgery in elderly patients with CSM...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28993094/characterization-of-diplopia-in-non-demented-patients-with-parkinson-s-disease
#19
Katharina A Schindlbeck, Shideh Schönfeld, Wanda Naumann, David J Friedrich, André Maier, Charlotte Rewitzer, Fabian Klostermann, Frank Marzinzik
INTRODUCTION: Although diplopia is considered a frequent symptom of Parkinson's disease (PD), little is known about its clinical manifestation, associated mechanisms and treatment. Here we characterized binocular diplopia in non-demented PD patients in an interdisciplinary setting. METHODS: PD patients were prospectively screened for diplopia, visual hallucinations, problems with spatial perception, contrast sensitivity, presence of blurred vision, and history of ophthalmological comorbidities via interview...
September 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28991700/cardiac-sympathetic-denervation-and-dementia-in-de-novo-parkinson-s-disease-a-7-year-follow-up-study
#20
Mun Hee Choi, Jung Han Yoon, Suk Woo Yong
BACKGROUND: Postganglionic cardiac sympathetic denervation is evident in patients with early-stage Parkinson's disease (PD). Cardiac iodine-123-meta-iodobenzylguanidine (MIBG) uptake is correlated with the non-motor symptoms of PD, suggesting that low cardiac MIBG uptake may reflect wider alpha-synuclein pathology. In addition, low cardiac MIBG could be related to orthostatic hypotension in PD, which may affect cognition. However, the prognostic validity of baseline MIBG scintigraphy in terms of the risk of subsequent dementia remains unclear...
October 15, 2017: Journal of the Neurological Sciences
keyword
keyword
19983
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"