keyword
https://read.qxmd.com/read/38536604/oral-microbiota-and-porphyromonas-gingivalis-kgp-genotypes-altered-in-parkinson-s-disease-with-mild-cognitive-impairment
#1
JOURNAL ARTICLE
Dongcheng Li, Tengzhu Ren, Hao Li, Mingdi Huang, Jiaxin Chen, Qishan He, Wei Lv, Hailing Liu, Renshi Xu, Xiong Zhang
Cognitive impairment (CI) is a common complication of the non-motor symptoms in Parkinson's disease (PD), including PD with mild cognitive impairment (PD-MCI) and PD dementia. Recent studies reported the oral dysbiosis in PD and CI, respectively. Porphyromonas gingivalis (P. gingivalis), a pathogen of oral dysbiosis, plays an important role in PD, whose lysine-gingipain (Kgp) could lead to AD-type pathologies. No previous study investigated the composition of oral microbiota and role of P. gingivalis in PD-MCI...
March 27, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38534569/leveraging-deep-learning-for-fine-grained-categorization-of-parkinson-s-disease-progression-levels-through-analysis-of-vocal-acoustic-patterns
#2
JOURNAL ARTICLE
Hadi Sedigh Malekroodi, Nuwan Madusanka, Byeong-Il Lee, Myunggi Yi
Speech impairments often emerge as one of the primary indicators of Parkinson's disease (PD), albeit not readily apparent in its early stages. While previous studies focused predominantly on binary PD detection, this research explored the use of deep learning models to automatically classify sustained vowel recordings into healthy controls, mild PD, or severe PD based on motor symptom severity scores. Popular convolutional neural network (CNN) architectures, VGG and ResNet, as well as vision transformers, Swin, were fine-tuned on log mel spectrogram image representations of the segmented voice data...
March 21, 2024: Bioengineering
https://read.qxmd.com/read/38534318/nicotinic-acetylcholine-receptors-in-glial-cells-as-molecular-target-for-parkinson-s-disease
#3
REVIEW
Érica Novaes Soares, Ana Carla Dos Santos Costa, Gabriel de Jesus Ferrolho, Rodrigo Portes Ureshino, Bruk Getachew, Silvia Lima Costa, Victor Diogenes Amaral da Silva, Yousef Tizabi
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address neuronal loss and the progression of the disease...
March 7, 2024: Cells
https://read.qxmd.com/read/38529740/systemic-symptoms-in-huntington-s-disease-a-comprehensive-review
#4
REVIEW
Raja Mehanna, Joseph Jankovic
BACKGROUND: Although Huntington's disease (HD) is usually thought of as a triad of motor, cognitive, and psychiatric symptoms, there is growing appreciation of HD as a systemic illness affecting the entire body. OBJECTIVES: This review aims to draw attention to these systemic non-motor symptoms in HD. METHODS: We identified relevant studies published in English by searching MEDLINE (from 1966 to September 2023), using the following subject headings: Huntington disease, autonomic, systemic, cardiovascular, respiratory, gastrointestinal, urinary, sexual and cutaneous, and additional specific symptoms...
March 26, 2024: Movement Disorders Clinical Practice
https://read.qxmd.com/read/38528593/a-novel-large-intragenic-dpyd-deletion-causing-dihydropyrimidine-dehydrogenase-deficiency-a-case-report
#5
JOURNAL ARTICLE
Anna Malekkou, Marios Tomazou, Gavriella Mavrikiou, Maria Dionysiou, Theodoros Georgiou, Ioannis Papaevripidou, Angelos Alexandrou, Carolina Sismani, Anthi Drousiotou, Olga Grafakou, Petros P Petrou
BACKGROUND: Dihydropyrimidine dehydrogenase (DPD), is the initial and rate-limiting enzyme in the catabolic pathway of pyrimidines. Deleterious variants in the DPYD gene cause DPD deficiency, a rare autosomal recessive disorder. The clinical spectrum of affected individuals is wide ranging from asymptomatic to severely affected patients presenting with intellectual disability, motor retardation, developmental delay and seizures. DPD is also important as the main enzyme in the catabolism of 5-fluorouracil (5-FU) which is extensively used as a chemotherapeutic agent...
March 25, 2024: BMC Medical Genomics
https://read.qxmd.com/read/38528282/association-between-fatigue-and-mds-updrs-in-individuals-with-parkinson-s-disease-cross-sectional-study
#6
JOURNAL ARTICLE
Marcelle Brandão Terra, Josiane Lopes, Maria Eduarda Brandão Bueno, Luzia Aparecida Trinca, Suhaila Mahmoud Smaili
BACKGROUND: Fatigue is significant in the context of Parkinson's disease (PD), considering that one-third of patients classify it as the most restricting symptom in their daily life activities (DLAs). The objective was to verify the relationship (association) between fatigue and non-motor and motor symptoms of PD. METHODS: A cross-sectional study which included 100 individuals with PD. Initially, demographic and clinical data (modified Hoehn and Yahr scale-HY, anxiety, and depression) were collected...
March 26, 2024: Neurological Sciences
https://read.qxmd.com/read/38527507/-analysis-of-9-patients-with-adolescence-onset-methylenetetrahydrofolate-reductase-deficiency
#7
JOURNAL ARTICLE
H T Zhang, X Ma, Y Jin, M Q Li, J Q Song, Z H Chen, Y Liu, X P Lu, H Zheng, Y L Yang
Objective: To explore the diagnosis and treatment of adolescence-onset methylenetetrahydrofolate reductase (MTHFR) deficiency. Methods: This was a retrospective case study. Nine patients with adolescence-onset MTHFR deficiency were diagnosed at Peking University First Hospital from January 2016 to December 2022, and followed up for more than 1 year. Their general information, clinical manifestations, laboratory tests, cranial images, MTHFR gene variants, diagnosis, treatment, and outcome were analyzed retrospectively...
March 25, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38526870/longitudinal-evolution-and-plasma-biomarkers-for-excessive-daytime-sleepiness-in-parkinson-s-disease
#8
JOURNAL ARTICLE
Junyu Lin, Chunyu Li, Ruwei Ou, Yanbing Hou, Lingyu Zhang, Qianqian Wei, Kuncheng Liu, Qirui Jiang, Tianmi Yang, Yi Xiao, Dejiang Pang, Yujiao Yu, Wei Song, Bi Zhao, Xueping Chen, Jing Yang, Ying Wu, Huifang Shang
BACKGROUND: Excessive daytime sleepiness (EDS) is one of the most frequent non-motor symptoms in Parkinson's disease (PD); however, the pathogenesis of EDS is unclear, and there is a lack of information on plasma biomarkers for EDS in PD. We aimed to investigate the plasma biomarkers of EDS in a large PD cohort. METHODS: A total of 159 PD patients were included in the prospective cohort study and followed up annually for three years. Plasma biomarkers including glial fibrillary acidic protein, amyloid-beta, p-tau181, and neurofilament light chain (NfL), were measured using an ultrasensitive single-molecule array (SimoaTM) technology at each visit...
March 25, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38525905/treating-inflammation-to-reduce-stroke-risk-non-motor-symptoms-after-stroke-cerebral-microinfarcts-in-cancer-and-prognosis-in-cervical-dissection
#9
EDITORIAL
Hugh S Markus
No abstract text is available yet for this article.
April 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38523931/correlation-between-depression-and-quality-of-life-among-patients-with-parkinson-s-disease-an-analytical-cross-sectional-study
#10
JOURNAL ARTICLE
Priya Sujith, Porkodi Arjunan, Thomas Iype, Venkatesh Natarajan
Introduction Parkinson's disease (PD) is a progressive complex degenerative disorder characterised by several motor and non-motor symptoms that result in disability and deterioration of the patient's quality of life (QOL). Depression is the most common non-motor symptom that may severely alter the QOL. The objective of this study was to examine the correlation between depression and QOL among patients with PD who received treatment from a movement disorder clinic of a tertiary care teaching hospital in South India...
February 2024: Curēus
https://read.qxmd.com/read/38520160/the-role-of-orexin-in-parkinson-s-disease
#11
REVIEW
Alisha Braun, Jim Manavis, Akihiro Yamanaka, Youichirou Ootsuka, Peter Blumbergs, Larisa Bobrovskaya
Emerging evidence has implicated the orexin system in non-motor pathogenesis of Parkinson's disease. It has also been suggested the orexin system is involved in the modulation of motor control, further implicating the orexin system in Parkinson's disease. Parkinson's disease is the second most common neurodegenerative disease with millions of people suffering worldwide with motor and non-motor symptoms, significantly affecting their quality of life. Treatments are based solely on symptomatic management and no cure currently exists...
March 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38517805/opportunities-and-pitfalls-of-rem-sleep-behavior-disorder-and-olfactory-dysfunction-as-early-markers-in-parkinson-s-disease
#12
REVIEW
Beatrice Orso, Sarah Brosse, Johannes Frasnelli, Dario Arnaldi
During its pre-motor stage, Parkinson's disease (PD) presents itself with a multitude of non-motor symptoms with different degrees of specificity and sensitivity. The most important among them are REM sleep behavior disorder (RBD) and olfactory dysfunction. RBD is a parasomnia characterized by the loss of REM sleep muscle atonia and dream-enacting behaviors. Olfactory dysfunction in individuals with prodromal PD is usually described as hyposmia (reduced sense of smell) or anosmia (complete loss of olfactory function)...
March 22, 2024: Journal of Parkinson's Disease
https://read.qxmd.com/read/38517803/gait-adaptability-and-the-effect-of-ocular-disorders-on-visually-guided-walking-in-parkinson-s-disease
#13
JOURNAL ARTICLE
Carlijn D J M Borm, Debbie De Graaf, Bastiaan R Bloem, Thomas Theelen, Carel Hoyng, Nienke de Vries, Vivian Weerdesteyn
Gait disorders are a disabling feature of Parkinson's disease (PD). To avoid falls, people with PD should be able to adequately adapt their gait. This requires correct response inhibition and integration of visual information. In this small pilot study, we investigated PD-related impairments in gait adaptability and the influence of ocular disorders thereon. Compared with controls, persons with PD were less able to adapt their gait in unexpected situations (U = 21.5, p = 0.013), with only a small influence of ocular disorders on precision stepping (U = 6, p = 0...
March 22, 2024: Journal of Parkinson's Disease
https://read.qxmd.com/read/38516493/unveiled-a-case-of-n-methyl-d-aspartate-receptor-antibody-encephalitis-with-delayed-diagnosis-of-ovarian-teratoma
#14
Patricia Fleur J Andaya, Alejandro Bimbo F Diaz
N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is an autoimmune syndrome with potentially fatal sequelae causing profound dysregulation of neurotransmission. Patients most often present with a constellation of neuropsychiatric signs and symptoms, including behavioral changes, motor disturbances, and seizures. Frequently, the development of anti-NMDAR antibodies has been linked to specific malignancies, although the exact event that triggers the production of these antibodies remains unknown...
February 2024: Curēus
https://read.qxmd.com/read/38512027/rab3-phosphorylation-by-pathogenic-lrrk2-impairs-trafficking-of-synaptic-vesicle-precursors
#15
JOURNAL ARTICLE
Dan Dou, Jayne Aiken, Erika L F Holzbaur
Gain-of-function mutations in the LRRK2 gene cause Parkinson's disease (PD), characterized by debilitating motor and non-motor symptoms. Increased phosphorylation of a subset of RAB GTPases by LRRK2 is implicated in PD pathogenesis. We find that increased phosphorylation of RAB3A, a cardinal synaptic vesicle precursor (SVP) protein, disrupts anterograde axonal transport of SVPs in iPSC-derived human neurons (iNeurons) expressing hyperactive LRRK2-p.R1441H. Knockout of the opposing protein phosphatase 1H (PPM1H) in iNeurons phenocopies this effect...
June 3, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38508293/temporal-interference-stimulation-targets-deep-primate-brain
#16
JOURNAL ARTICLE
Ruobing Liu, Guanyu Zhu, Zhengping Wu, Yifei Gan, Jianguo Zhang, Jiali Liu, Liang Wang
Temporal interference (TI) stimulation, a novel non-invasive stimulation strategy, has recently been shown to modulate neural activity in deep brain regions of living mice. Yet, it is uncertain if this method is applicable to larger brains and whether the electric field produced under traditional safety currents can penetrate deep regions as observed in mice. Despite recent model-based simulation studies offering positive evidence at both macro- and micro-scale levels, the absence of electrophysiological data from actual brains hinders comprehensive understanding and potential application of TI...
March 18, 2024: NeuroImage
https://read.qxmd.com/read/38503261/off-episode-quality-of-life-impact-scale-offelia-a-new-measure-of-quality-of-life-for-off-episodes-in-parkinson-s-disease
#17
JOURNAL ARTICLE
Maja Kuharic, Victoria Kulbokas, Kent Hanson, Jonathan L Nazari, Kanya K Shah, Ai Nguyen, Tara Hensle, Connie Marras, Melissa J Armstrong, Yash J Jalundhwala, A Simon Pickard
INTRODUCTION: OFF Episodes occur in people with Parkinson's disease when their medication wears off, and motor and/or non-motor symptoms emerge. Existing measures used to assess OFF Episodes focus on the time spent in OFF Episodes through diaries or by identifying symptoms, but they are limited in their ability to capture the severity and functional impact of OFF episodes. The aim of this study was to develop and validate a new instrument, called "OFFELIA," that measures the impact of OFF episodes on the quality of life of individuals with Parkinson's disease...
March 12, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38502556/conservative-non-pharmacological-treatments-for-chemotherapy-induced-peripheral-neuropathies-in-women-treated-for-breast-cancer-a-systematic-review
#18
JOURNAL ARTICLE
Gianpaolo Ronconi, Dario M Gatto, Sefora Codazza, Mariantonietta Ariani, Eloisa Martire, Luca Cerretti, Valentina Carella, Daniele Coraci, Giorgio Ferriero, Paola E Ferrara
INTRODUCTION: Over the last few decades, the use of neo/adjuvant therapies has significantly increased the number of breast cancer survivors who experience chemotherapy-induced peripheral neuropathy (CIPN). To date, few, low-efficacy, pharmacological remedies exist to manage this side effect. For this reason, alternative treatments are increasingly being investigated as possible strategies to prevent or promote faster recovery from CIPN. In this review we aimed to provide an overview of the literature evidence regarding all the non-pharmacological and rehabilitative interventions for patients affected by CIPN secondary to breast cancer care...
March 19, 2024: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38499888/hyposmia-correlates-with-axial-signs-and-gait-disorder-in-parkinson-s-disease-an-italian-olfactory-identification-test-study
#19
JOURNAL ARTICLE
Nicola Tambasco, Alessandro Mechelli, Pasquale Nigro, Simone Simoni, Federico Paolini Paoletti, Paolo Eusebi, Elona Brahimi, Carlo Maremmani, Lucilla Parnetti
BACKGROUND: Olfactory dysfunction is a non-motor symptom and an important biomarker of Parkinson's disease (PD) because of its high prevalence (> 90%). Whether hyposmia correlates with motor symptoms is unclear. In the present study, we aim to investigate the relationship between olfactory impairment with both motor and non-motor features and disease variables (disease duration, stage, and severity). METHODS: One-hundred fifty-four PD patients were evaluated...
March 19, 2024: Neurological Sciences
https://read.qxmd.com/read/38499659/sleep-deprivation-induces-late-deleterious-effects-in-a-pharmacological-model-of-parkinsonism
#20
JOURNAL ARTICLE
L B Lopes-Silva, D M G Cunha, A C Lima, V S Bioni, N Gonçalves, J P F Kurita, R Wuo-Silva, R H Silva
Parkinson's disease is a degenerative, chronic and progressive disease, characterized by motor dysfunctions. Patients also exhibit non-motor symptoms, such as affective and sleep disorders. Sleep disorders can potentiate clinical and neuropathological features and lead to worse prognosis. The goal of this study was to evaluate the effects of sleep deprivation (SD) in mice submitted to a progressive pharmacological model of Parkinsonism (chronic administration with a low dose of reserpine). Male Swiss mice received 20 injections of reserpine (0...
March 18, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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