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H H Kerschbaum
Parvalbumin-like material was localized using an immunoeytochcmieal method, in neurons of the central nervous system and in cells intermingled in the skin of the earthworm. Lumbricus terreslris L. Parvalbumin-immunoreactive material was found in the cytoplasm of perikarya and neutrites, not in the nucleoplasm. In contrast to vertebrates, Lumbricus musculature did not contain parvalbumin-immunoreactive material.
1992: Tissue & Cell
M Lu, W Witke, D J Kwiatkowski, K S Kosik
Growth cones extend dynamic protrusions called filopodia and lamellipodia as exploratory probes that signal the direction of neurite growth. Gelsolin, as an actin filament-severing protein, may serve an important role in the rapid shape changes associated with growth cone structures. In wild-type (wt) hippocampal neurons, antibodies against gelsolin labeled the neurite shaft and growth cone. The behavior of filopodia in cultured hippocampal neurons from embryonic day 17 wt and gelsolin null (Gsn-) mice (Witke, W...
September 22, 1997: Journal of Cell Biology
K Ohta, H Iwamasa, U Drescher, H Terasaki, H Tanaka
Eph-related receptor tyrosine kinases and ligands are expressed at high levels in the developing nervous system, giving rise to the proposal that they are involved in neuronal connection. Cek8 was found to be predominantly expressed on a subset of motoneurons innervating limb but not body muscles during motoneuron axonal growth. Here we show that the ligands RAGS and ELF-1 were expressed in limb buds and that they activated Cek8 when presented in membrane-bound or clustered forms of Fc chimeric proteins but not in unclustered soluble forms...
June 1997: Mechanisms of Development
D E Kang, T Saitoh, X Chen, Y Xia, E Masliah, L A Hansen, R G Thomas, L J Thal, R Katzman
The presence of the APOE epsilon 4 allele encoding apolipoprotein E4 (apoE4) is the major genetic risk factor for late-onset Alzheimer's disease (AD). However, the molecular and cellular mechanisms by which APOE epsilon 4 renders AD risk are unclear. In this report, we present genetic evidence that an apoE receptor, LRP, may be associated with the expression of late-onset AD. Using a biallelic genetic marker in exon 3 of LRP, late-onset AD cases markedly differed from the control subjects in the distribution of LRP genotypes, and this difference was highly accentuated among AD cases with positive family history of senile dementia...
July 1997: Neurology
H K Edelberg, J Y Wei
The pathological hallmarks of Alzheimer's disease (AD) are amyloid angiopathy (AA), neutritic plaques (NP), and neurofibrillary tangles (NFT). This article will provide an update on Alzheimer's disease as well as discuss the key elements of a proposed multi-step pathogenic pathway. In an attempt to simplify this complex process, the focus will be on the production of NP/AA and NFT and the mechanisms of disease underlying their formation. In particular, this review will explore the possibility that AD is in part an inflammatory or immunological process, the potential role of oxidative DNA damage from oxygen free radical metabolites, and/or the putative role of excitotoxicity or ischemic neurological injury...
October 25, 1996: Mechanisms of Ageing and Development
P C Begovac, B D Shur
Neurite outgrowth from PC12 pheochromocytoma cells, as well as from peripheral and central nervous system neurons in vitro, is mediated by the extracellular matrix molecule, laminin. We have recently shown that mesenchymal cell spreading and migration on laminin is mediated, in part, by the cell surface enzyme, beta 1,4 galactosyltransferase (GalTase). GalTase is localized on lamellipodia of migrating cells where it functions as a laminin receptor by binding to specific N-linked oligosaccharides in laminin (Runyan et al...
February 1990: Journal of Cell Biology
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