Han Xiao-Hong, Wang Meng, Pan Yang-Yang, Fan Jiang-Feng, Wang Jing-Lei, Zhao Ling, Wang Ya-Ying, Zhang Tong-Xiang, Zhao Tian, Ding Tian-Yi, Cui Yan, Yu Si-Jiu
Follicle-stimulating hormone (FSH), luteinizing hormone (LH), miR-23a, apoptosis signal-regulating kinase 1(ASK1)/c-Jun N-terminal kinase (JNK), autophagy and apoptosis play crucial roles in follicular development. However, their role in yak granulosa cells (GCs) remains unknown. Therefore, we examined the effect of miR-23a, ASK1, FSH, and LH on apoptosis, autophagy, the release and reception of some steroid hormones in these cells. Our results showed that miR-23a overexpression significantly increased the abundance of beclin-1, the LC3II/I ratio, and the number of Ad-mRFP-GFP-LC3-labeled autophagosomes, and decreased p62 abundance...
December 19, 2023: Cellular Signalling