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https://www.readbyqxmd.com/read/27901103/fsh-protects-mouse-granulosa-cells-from-oxidative-damage-by-repressing-mitophagy
#1
Ming Shen, Yi Jiang, Zhiqiang Guan, Yan Cao, Shao-Chen Sun, Honglin Liu
Oxidative stress has been implicated in triggering granulosa cell (GC) death during follicular atresia. Recent studies suggested that follicle-stimulating hormone (FSH) has a pivotal role in protecting GCs from oxidative injury, although the exact mechanism remains largely unknown. Here, we report that FSH promotes GC survival by inhibiting oxidative stress-induced mitophagy. The loss of GC viability caused by oxidative stress was significantly reduced after FSH treatment, which was correlated with impaired activation of mitophagy upon oxidative stress...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896503/effect-of-pgc-1%C3%AE-overexpression-or-silencing-on-mitochondrial-apoptosis-of-goat-luteinized-granulosa-cells
#2
Guo-Min Zhang, Ming-Tian Deng, Yan-Li Zhang, Yi-Xuan Fan, Yong-Jie Wan, Hai-Tao Nie, Zi-Yu Wang, Feng Wang, Zhi-Hai Lei
During goat follicular development, abnormal expression of peroxisome proliferator- activated receptor gamma coactivator-1 alpha (PGC-1α) in granulosa cells (GCs) may contribute to follicular atresia with unknown regulatory mechanisms. In this study, we investigate the effect of ectopic expression or interference of PGC-1α on cell apoptosis of goat first passage granulosa cells (FGCs) in vitro. The results indicate that PGC-1α silencing by short hairpin RNA (shRNA) in goat FGCs significantly reduced mitochondrial DNA (mtDNA) copy number (P < 0...
November 28, 2016: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/27882941/tgf-%C3%AE-signaling-controls-fshr-signaling-reduced-ovarian-granulosa-cell-apoptosis-through-the-smad4-mir-143-axis
#3
Xing Du, Lifan Zhang, Xinyu Li, Zengxiang Pan, Honglin Liu, Qifa Li
Follicle-stimulating hormone receptor (FSHR) and its intracellular signaling control mammalian follicular development and female infertility. Our previous study showed that FSHR is downregulated during follicular atresia of porcine ovaries. However, its role and regulation in follicular atresia remain unclear. Here, we showed that FSHR knockdown induced porcine granulosa cell (pGC) apoptosis and follicular atresia, and attenuated the levels of intracellular signaling molecules such as PKA, AKT and p-AKT. FSHR was identified as a target of miR-143, a microRNA that was upregulated during porcine follicular atresia...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27865417/knock-down-of-apoptosis-inducing-factor-gene-protects-endoplasmic-reticulum-stress-mediated-goat-granulosa-cell-apoptosis
#4
Diqi Yang, Tingting Jiang, Pengfei Lin, Huatao Chen, Lei Wang, Nan Wang, Fan Zhao, Aihua Wang, Yaping Jin
The apoptosis of granulosa cells is the main cause of follicular atresia, and endoplasmic reticulum (ER) stress is involved in the apoptosis of granulosa cells. Apoptosis inducing factor (AIF) mediates caspase-independent apoptosis and causes chromatin condensation and DNA fragmentation, but its role in ER stress-mediated granulosa cell apoptosis during goat follicular atresia remains largely unknown. The aim of this study was to investigate the function of AIF in the apoptosis of goat granulosa cells mediated by ER stress...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27821562/oxidative-stress-in-granulosa-lutein-cells-from-in-vitro-fertilization-patients
#5
Julio Ávila, Rebeca González-Fernández, Deborah Rotoli, Jairo Hernández, Angela Palumbo
Ovarian aging is associated with gradual follicular loss by atresia/apoptosis. Increased production of toxic metabolites such as reactive oxygen species (ROS) and reactive nitrogen species as well as external oxidant agents plays an important role in the process of ovarian senescence and in the pathogenesis of ovarian pathologies such as endometriosis and polycystic ovary syndrome (PCOS). This review provides a synthesis of available studies of oxidative stress (OS) in the ovary, focusing on the most recent evidence obtained in mural granulosa-lutein (GL) cells of in vitro fertilization patients...
December 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27752308/characterization-of-blood-flow-and-the-effects-of-exogenous-estradiol-benzoate-on-residual-follicles-formed-after-ultrasound-guided-transvaginal-follicle-aspiration-in-cattle
#6
Alberto Mansur Ghetti, Luiz Gustavo Bruno Siqueira, Eduardo Kenji Nunes Arashiro, Miller Pereira Palhao, Felipe Zandonadi Brandao, Joao Henrique Moreira Viana
BACKGROUND: Removal of the follicular content by ultrasound-guided transvaginal follicle aspiration (TVFA) may fail to induce immediate atresia and loss of function, resulting in the occurrence of residual follicles (RF). The aims of this study were to characterize the blood flow in RF and to determine the effects of the treatment with estradiol benzoate on RF fate. Lactating, cyclic Holstein-Gir crossbred cows were used. In Experiment 1, follicular wave emergence (D0) was synchronized in cows (n = 10) and follicular growth was then monitored by transrectal ultrasonography from D0 to D8, followed by TVFA of the largest follicle present on the ovaries 24 h later...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27708774/effects-of-chronic-heat-stress-on-granulosa-cell-apoptosis-and-follicular-atresia-in-mouse-ovary
#7
Jieyun Li, Hui Gao, Zhen Tian, Yi Wu, Yingzheng Wang, Yuan Fang, Lu Lin, Ying Han, Shuaishuai Wu, IhteshamUl Haq, Shenming Zeng
BACKGROUND: Heat stress is known to alter follicular dynamics and granulosa cell function and may contribute to the diminished reproductive efficiency commonly observed in mammals during the summer. Although several investigators have studied heat-induced ovarian injury, few reports have focused on the effects of chronic heat stress on ovarian function and the molecular mechanisms through which it induces ovarian injury. METHODS: In Exp. 1, 48 female mice were assigned to a control or heat-stressed treatment...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27684714/paraptosis-like-cell-death-in-wistar-rat-granulosa-cells
#8
Nayeli Torres-Ramírez, María L Escobar, Gerardo H Vázquez-Nin, Rosario Ortiz, Olga M Echeverría
Follicular atresia, a common process present in all mammals, involves apoptotic and autophagic cell death. However, the participation of paraptosis, a type of caspase-independent cell death, during follicular atresia is unknown. This study found swollen endoplasmic reticulum in the granulosa cells of adult Wistar rats. Calnexin was used as a marker of the endoplasmic reticulum at the ultrastructural and optical levels. The cells with swelling of the endoplasmic reticulum were negative to the TUNEL assay and active caspase-3 immunodetection, indicating that this swelling is not part of any apoptotic or autophagic process...
October 2016: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/27664382/a-mirna-target-network-putatively-involved-in-follicular-atresia
#9
F X Donadeu, B T Mohammed, J Ioannidis
In a previous microarray study, we identified a subset of micro RNAS (miRNAs), which expression was distinctly higher in atretic than healthy follicles of cattle. In the present study, we investigated the involvement of those miRNAs in granulosa and theca cells during atresia. Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR) confirmed that miR-21-5p/-3p, miR-150, miR-409a, miR-142-5p, miR-378, miR-222, miR-155, and miR-199a-5p were expressed at higher levels in atretic than healthy follicles (9-17 mm, classified based on steroidogenic capacity)...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27638465/dual-role-for-the-unfolded-protein-response-in-the-ovary-adaption-and-apoptosis
#10
Ning Huang, Yang Yu, Jie Qiao
The endoplasmic reticulum (ER) is the principal organelle responsible for several specific cellular functions including synthesis and folding of secretory or membrane proteins, lipid metabolism, and Ca(2+) storage. Different physiological as well as pathological stress conditions can, however, perturb ER homeostasis, giving rise to an accumulation of unfolded or misfolded proteins in the ER lumen, a condition termed ER stress. To deal with an increased folding demand, cells activate the unfolded protein response (UPR), which is initially protective but can become detrimental if ER stress is severe and prolonged...
September 8, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27569271/altered-state-of-primordial-follicles-in-neonatal-and-early-infantile-rats-due-to-maternal-hypothyroidism-light-and-electron-microscopy-approach
#11
Jelena Danilović Luković, Aleksandra Korać, Ivan Milošević, Tijana Lužajić, Nela Puškaš, Milica Kovačević Filipović, Anita Radovanović
Thyroid hormones (TH) are one of the key factors for normal prenatal development in mammals. Previously, we showed that subclinical maternal hypothyroidism leads to premature atresia of ovarian follicles in female rat offspring in the pre-pubertal and pubertal periods. The influence of decreased concentration of TH on primordial follicles pool formation during neonatal and early infantile period of rat pups was not investigated previously. Maternal hypothyroidism during pregnancy has irreversible negative influence on primordial follicles pool formation and population of resting oocytes in female rat offspring...
November 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27562289/ovarian-ageing-the-role-of-mitochondria-in-oocytes-and-follicles
#12
Pascale May-Panloup, Lisa Boucret, Juan-Manuel Chao de la Barca, Valérie Desquiret-Dumas, Véronique Ferré-L'Hotellier, Catherine Morinière, Philippe Descamps, Vincent Procaccio, Pascal Reynier
BACKGROUND: There is a great inter-individual variability of ovarian ageing, and almost 20% of patients consulting for infertility show signs of premature ovarian ageing. This feature, taken together with delayed childbearing in modern society, leads to the emergence of age-related ovarian dysfunction concomitantly with the desire for pregnancy. Assisted reproductive technology is frequently inefficacious in cases of ovarian ageing, thus raising the economic, medical and societal costs of the procedures...
August 25, 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27535959/the-novel-pig-in-vitro-maturation-system-to-improve-developmental-competence-of-oocytes-derived-from-atretic-non-vascularized-follicle
#13
Asako Okamoto, Maki Ikeda, Aeri Kaneko, Chika Kishida, Masayuki Shimada, Yasuhisa Yamashita
The in vitro maturation (IVM) technique is beneficial for producing animal offspring, but the blastocyst rate is low after IVM. In this technique, cumulus-oocyte complexes (COCs) are collected from medium size follicles. The follicles are ultimately selected as large dominant follicles or atretic follicles; therefore it is possible that the COCs collected using IVM are contaminated by follicles that will develop into large follicles and induce atresia. In the dominant follicles, estradiol-17beta and progesterone induce the differentiation of follicular somatic cells which exhibit the ability to respond to ovulation during follicular development...
August 17, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27526019/-lungs-hassalloid%C3%A2-s-like-bodies-in-children-with-epidermolysis-bullosa-junctionalis-and-bart%C3%A2-s-syndrome
#14
Katarína Adamicová, Tomáš Balhárek, Želmíra Fetisovová, Yvetta Mellová
Epidermolysis bullosa and Bart´s syndrome are fairly accurately documented diseases by histopathology. In the article the authors describe interesting and hitherto undescribed phenomenon in the lungs male infant with epidermolysis bullosa junctionalis and Barts syndrome, who died 17 days after birth and 13 days after surgery for pyloric atresia, on multiorgan failure within basic congenital diseases.Histologically in lung alveoli was found to the massive presence of foamy macrophages and numerous globoid formations resembling morphological and immunohistochemical "Hassall´s" bodies in a thymus of the newborn...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27495896/dehp-exposure-in-utero-disturbs-sex-determination-and-is-potentially-linked-with-precocious-puberty-in-female-mice
#15
Yongan Wang, Qing Yang, Wei Liu, Mingxi Yu, Zhou Zhang, Xiaoyu Cui
Human's ubiquitous exposure to di (2-ethylhexyl) phthalate (DEHP) is thought to be associated with female reproductive toxicity. Previous studies found that DEHP inhibited follicle growth and decreased estradiol levels in adult female mice. However, limited information is available on the link between in utero DEHP exposure and ovarian development in female mouse offspring. The present study evaluates the disturbances in regulatory genes involved in female sex determination and the ovarian outcomes in fetal and postnatal female mice treated with in utero DEHP exposure...
September 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27436181/age-associated-up-regulation-of-egr1-promotes-granulosa-cell-apoptosis-during-follicle-atresia-in-mice-through-the-nf-%C3%AE%C2%BAb-pathway
#16
Suzhen Yuan, Jingyi Wen, Jing Cheng, Wei Shen, Su Zhou, Wei Yan, Lu Shen, Aiyue Luo, Shixuan Wang
Follicular atresia is the main process responsible for the loss of follicles and oocytes from the ovary, and it is the root cause of ovarian aging. Apoptosis of granulosa cells (GCs) is the cellular mechanism responsible for follicular atresia in mammals. Recent advances have highlighted fundamental roles for EGR1 in age-related diseases via the induction of apoptosis. In the present study, we found that the expression of EGR1 was significantly increased in aged mouse ovaries compared with young ovaries. Immunohistochemical analysis revealed strongly positive EGR1 staining in atretic follicles, especially in apoptotic granulosa cells...
November 2016: Cell Cycle
https://www.readbyqxmd.com/read/27417237/microrna-let-7g-regulates-mouse-granulosa-cell-autophagy-by-targeting-insulin-like-growth-factor-1-receptor
#17
Jilong Zhou, Wang Yao, Kaiqing Liu, Qiannan Wen, Wangjun Wu, Honglin Liu, Qifa Li
As an important type of somatic cell, granulosa cells play a major role in deciding the fate of follicles. Therefore, analyses of granulosa cell apoptosis and follicular atresia have become hotspots of animal research. Autophagy is a cellular catabolic mechanism that protects cells from stress conditions, including starvation, hypoxia, and accumulation of misfolded proteins. However, the relationship between autophagy and apoptosis in granulosa cells is not well known. Here, we demonstrate that let-7g regulates the mouse granulosa cell autophagy signaling pathway by inhibiting insulin-like growth factor 1 receptor expression and affecting the phosphorylation of protein kinase B/mammalian target of rapamycin...
September 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27413107/embryonic-atrazine-exposure-elicits-alterations-in-genes-associated-with-neuroendocrine-function-in-adult-male-zebrafish
#18
Sara E Wirbisky, Maria S Sepúlveda, Gregory J Weber, Amber S Jannasch, Katharine A Horzmann, Jennifer L Freeman
The developmental origins of health and disease (DOHaD) hypothesis states that exposure to environmental stressors early in life can elicit genome and epigenome changes resulting in an increased susceptibility of a disease state during adulthood. Atrazine, a common agricultural herbicide used throughout the Midwestern United States, frequently contaminates potable water supplies and is a suspected endocrine disrupting chemical. In our previous studies, zebrafish was exposed to 0, 0.3, 3, or 30 parts per billion (μg/l) atrazine through embryogenesis, rinsed, and allowed to mature to adulthood...
September 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27391761/effects-of-melatonin-on-follicular-atresia-and-granulosa-cell-apoptosis-in-the-porcine
#19
Yamei He, Honghui Deng, Zhongliang Jiang, Qingwang Li, Meihong Shi, Huali Chen, Zengsheng Han
The accumulation of reactive oxygen species is detrimental to the health of the ovarian follicle. The protective, antioxidant properties of melatonin, an endogenous component of porcine follicular fluid, on apoptosis of granulosa cells were evaluated in this study. Porcine granulosa cells from medium-sized (3-5 mm), healthy follicles were cultured in serum-free conditions with melatonin (0, 0.01, 0.1, 1.0, 10, and 100 ng/mL) with or without its receptor antagonist, luzindole, followed by evaluation of apoptotic markers in the treated cells...
August 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27346587/effect-of-hormonal-synchronisation-and-or-short-term-supplementation-with-maize-on-follicular-dynamics-and-hormone-profiles-in-goats-during-the-non-breeding-season
#20
D M Nogueira, J Cavalieri, L A Fitzpatrick, B Gummow, D Blache, A J Parker
This study aimed to evaluate the reproductive response of anoestrous goats that were either hormonally treated and/or supplemented with maize for 9days to determine which treatment combination was the most effective in enhancing follicular development and ovulation rate, and whether these responses were associated with increases in metabolic hormones. The experiment was carried out using 28 does, using a 2×2 factorial design with seven does in each group to test the effect of synchronisation of oestrus, supplementation with maize and their interactions...
August 2016: Animal Reproduction Science
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