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follicular atresia

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https://www.readbyqxmd.com/read/29767707/preantral-follicular-atresia-occurs-mainly-through-autophagy-while-antral-follicles-degenerate-mostly-through-apoptosis
#1
Li Meng, Sabrina Z Jan, Geert Hamer, Ans M van Pelt, Inge van der Stelt, Jaap Keijer, Katja J Teerds
There is general agreement that granulosa cell apoptosis is the cause of antral follicle attrition. Less clear is whether this pathway is also activated in case of preantral follicle degeneration, as several reports mention that the incidence of granulosa cell apoptosis in preantral follicles is negligible. Our objective is therefore to determine which cell-death pathways are involved in preantral and antral follicular degeneration.Atretic preantal and antral follicles were investigated using immunohistochemistry and laser-capture micro-dissection followed by qRT-PCR...
May 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29743261/initiation-of-follicular-atresia-gene-networks-during-early-atresia-in-pig-ovaries
#2
Jinbi Zhang, Yang Liu, Wang Yao, Qifa Li, Hong-Lin Liu, Zengxiang Pan
In mammals, more than 99% of ovarian follicles undergo a degenerative process known as atresia. The molecular events involve in atresia initiation remain incompletely understood. The objective of this study was to analyze differential gene expression profiles of medium antral ovarian follicles during early atresia in pig. The transcriptome evaluation was performed on cDNA microarrays using healthy and early atretic follicle samples and was validated by quantitative PCR. Annotation analysis applying current database (sus scrofa 11...
May 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29725001/ablation-of-beta-subunit-of-protein-kinase-ck2-in-mouse-oocytes-causes-follicle-atresia-and-premature-ovarian-failure
#3
Qiu-Xia Liang, Zhen-Bo Wang, Fei Lin, Chun-Hui Zhang, Hong-Mei Sun, Liang Zhou, Qian Zhou, Heide Schatten, Filhol-Cochet Odile, Boldyreff Brigitte, Qing-Yuan Sun, Wei-Ping Qian
Premature ovarian failure (POF), a major cause of female infertility, is a complex disorder, but the molecular mechanisms underlying the disorder are only poorly understood. Here we report that protein kinase CK2 contributes to maintaining follicular survival through PI3K/AKT pathway and DNA damage response pathway. Targeted deletion of CK2β in mouse oocytes from the primordial follicle stage resulted in female infertility, which was attributed to POF incurring by massive follicle atresia. Downregulated PI3K/AKT signaling was found after CK2β deletion, indicated by reduced level of phosphorylated AKT (S473, T308, and S129) and altered AKT targets related to cell survival...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29723543/the-transcription-factor-smad4-and-mir-10b-contribute-to-e2-release-and-cell-apoptosis-in-ovarian-granulosa-cells-by-targeting-cyp19a1
#4
Qiqi Li, Xing Du, Zengxiang Pan, Lifan Zhang, Qifa Li
The cytochrome P450 family 19 subfamily A member 1 (CYP19A1) gene, encodes aromatase, a key enzyme in estradiol (E2) synthesis, and is down-regulated during porcine follicular atresia. However, its role in and the mechanism of transcriptional repression in follicular atresia is largely unknown. In the present study, we show that the CYP19A1 gene stimulates E2 release and inhibits cell apoptosis in porcine granulosa cells (GCs). SMAD4, an anti-apoptotic moderator, was identified as a transcription factor of the porcine CYP19A1 gene and enhanced the expression and function of CYP19A1 in porcine GCs through direct binding to a SMAD4-binding element (SBE) within the promoter region of CYP19A1 gene...
April 30, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29706932/potential-functions-of-igfbp-2-for-ovarian-folliculogenesis-and-steroidogenesis
#5
REVIEW
Marion Spitschak, Andreas Hoeflich
Ovarian follicles, as transient structural and functional complexes with the oocyte and the associated cells, determine the female reproductive cycle and thus fertility. Ovarian function is subject to the strict control of hormones and growth factors and thus regulated by auto-, para-, and endocrine mechanisms but influenced also by endogenous factors. During the waves of follicular growth and development, one follicle (monoovulatory) or a limited number of them (polyovulatory) are selected under hypothalamic-gonadal control for maturation until ovulation, resulting in the fertile oocyte...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29684721/oocyte-atresia-in-wt-hdrr-and-p53-medaka-oryzias-latipes-exposed-to-uva
#6
A H Sayed, Rania F Ismail, Hiroshi Mitani
The negative effects of ambient ultraviolet (UVA) on the water environment have been recently highlighted; UVA can create deleterious effects by stimulating stress on pelagic organisms. Little is known about UVA effects on oocyte characteristics of female fish. In the present study we explored the effects of exposure to ecologically relevant levels of simulated UVA radiation on ovaries of two major strains WT (HdrR) and P53 (-/-) of medaka (Oryzias latipes) mature female. Fish were assigned to control and three UVA-exposed groups as (15 min, 30 min, and 60 min/day) for three days and sample selection was 24 h and 14 days after exposure...
April 12, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29681242/germ-cell-depletion-from-mammalian-ovary-possible-involvement-of-apoptosis-and-autophagy
#7
REVIEW
Pramod K Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Shilpa Prasad, Ashutosh N Pandey, Shail K Chaube
Mammalian ovary contains millions of germ cells during embryonic life but only few of them are culminated into oocytes that achieve meiotic competency just prior to ovulation. The majority of germ cells are depleted from ovary through several pathways. Follicular atresia is one of the major events that eliminate germ cells from ovary by engaging apoptotic as well as non-apoptotic pathways of programmed cell death. Apoptosis is characterized by several morphological changes that include cell shrinkage, nuclear condensation, membrane blebbing and cytoplasmic fragmentation by both mitochondria- as well as death receptor-mediated pathways in encircling granulosa cells and oocyte...
April 23, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29676088/-explore-microcosmic-connection-between-autophagy-mechanism-and-follicular-development-based-on-kidney-governing-reproduction-theory
#8
REVIEW
Jun Bai, Ke-Ming Wu, Ran-Ran Gao
In the theory of traditional Chinese medicine(TCM) that "kidney storing essence and governing reproduction", reproductive essence is an important part of the kidney essence and acts as the original material of offspring embryos. Sperm, oocyte and zygote should be all included in the range of reproductive essence. Ovum is the essence of reproduction from inborn. The follicles maturation depends on the quality of oocyte and the vigor of kidney essence. Meanwhile, discharge of mature ovum relies on the stimulation and promotion by kidney Qi...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29668890/luteinizing-hormone-facilitates-antral-follicular-maturation-and-survival-via-thecal-paracrine-signaling-in-cattle
#9
Katsushige Hattori, Makoto Orisaka, Shin Fukuda, Kimihisa Tajima, Yukiko Yamazaki, Tetsuya Mizutani, Yoshio Yoshida
The use of LH supplementation in assisted reproductive technology (ART) cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral follicles, we used an in vitro two-cell system that involved co-culturing bovine granulosa cells (GC) and theca cells (TC) on a collagen membrane. Treatment of TC with LH stimulated androgen production in TC by inducing the expression of androgenic factors, subsequently increasing estrogen biosynthesis in GC by providing androgen substrates and inducing aromatase expression...
April 13, 2018: Endocrinology
https://www.readbyqxmd.com/read/29668885/follicle-capacitation-a-meta-analysis-to-investigate-the-transcriptome-dynamics-following-fsh-decline-in-bovine-granulosa-cells
#10
David A Landry, Marc-André Sirard
In recent years, exciting progress was made to improve the embryo outcome after ovarian stimulation in domestic animals. The practice of follicle-stimulating hormone (FSH) withdrawal, which is defined as the period of time between the last injection of FSH and oocyte retrieval, resulted in embryo yields significantly superior. Since then, specific changes in the transcriptome of granulosa cells were associated with the increase and also the decline in oocyte developmental competence following the FSH decline...
April 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29643837/insulin-like-growth-factor-binding-proteins-and-igfbp-proteases-a-dynamic-system-regulating-the-ovarian-folliculogenesis
#11
REVIEW
Sabine Mazerbourg, Philippe Monget
The aim of the present article is to update our understanding of the expression of the insulin-like growth factor binding proteins (IGFBPs), IGFBP proteases and their implication in the different processes of ovarian folliculogenesis in mammals. In the studied species, IGFs and several small-molecular weight IGFBPs (in particular IGFBP-2 and IGFBP-4) are considered, respectively, as stimulators and inhibitors of follicular growth and maturation. IGFs play a key role in sensitizing ovarian granulosa cells to FSH action during terminal follicular growth...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29589294/examination-of-the-ovotoxicity-of-5-fluorouracil-in-mice
#12
M Lambouras, S H Liew, K Horvay, H E Abud, J M Stringer, Karla J Hutt
PURPOSE: Undesirable side effects of cancer treatments are common and include damage to the ovary, and depletion of the follicle reserve, which if severe enough, can lead to infertility and early menopause. Antimetabolite drugs, such as 5-fluorouracil (5-FU), are not considered to be detrimental to the ovary, but the ovotoxicity of 5-FU has not been evaluated in any detail. The purpose of this study was to evaluate the effects of 5-FU on follicle number. METHODS: In this study, adult female C57Bl6 mice (n = 4-6 animals/group) received a single dose of saline or 5-FU (150 mg/kg) and markers of ovarian damage and follicle depletion were assessed 12 h and 7 days later...
March 27, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29544632/involvement-of-bone-morphogenetic-proteins-bmp-in-the-regulation-of-ovarian-function
#13
Sheena L P Regan, Phil G Knight, John L Yovich, Yee Leung, Frank Arfuso, Arun Dharmarajan
Primordial germ cells migrate to the fetal gonads and proliferate during gestation to generate a fixed complement of primordial follicles, the so-called ovarian reserve. Primordial follicles comprise an oocyte arrested at the diplotene stage of meiosis, surrounded by a layer of pregranulosa cells. Activation of primordial follicles to grow beyond this arrested stage is of particular interest because, once activated, they are subjected to regulatory mechanisms involved in growth, selection, maturation, and ultimately, ovulation or atresia...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29512695/sumo2-modification-of-aurora-b-and-its-impact-on-follicular-development-and-atresia-in-the-mouse-ovary
#14
Jing Cao, Xiao-Ming Liu, Li-Lin Huang, Li Wang, Xiao-Fei Jiao, Li-Jun Huo
In the mammalian ovary, >99% follicles fail to ovulate due to apoptosis in granulosa cells. Aurora B, a core subunit enzyme of the chromosomal passenger complex, exerts a crucial role in microtubule‑kinetochore attachment, and has been reported to be modified by small ubiquitin‑related modifier (SUMO) proteins. However, the details of how Aurora B and its SUMOylation impact on follicular development have yet to be fully elucidated. The aim of the present study was to explore the roles, and possible molecular mechanism, of Aurora B and its SUMOylation in the granulosa cells of the mouse follicle...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29482665/study-on-the-relationship-between-expression-patterns-of-cocaine-and-amphetamine-regulated-transcript-and-hormones-secretion-in-porcine-ovarian-follicles
#15
Pengfei Li, Jinzhu Meng, Jiongjie Jing, Qingling Hao, Zhiwei Zhu, Jianbo Yao, Lihua Lyu
BACKGROUND: Cocaine-and amphetamine regulated transcript (CART) is an endogenous neuropeptide, which is widespread in animals, plays a key role in regulation of follicular atresia in cattle and sheep. Among animal ovaries, CART mRNA was firstly found in the cattle ovaries. CART was localized in the antral follicles oocytes, granulosa and cumulus cells by immunohistochemistry and in situ hybridization. Further research found that secretion of E2 was inhibited in granulosa cells with a certain dose of CART, the effect depends on the stage of cell differentiation, suggesting that CART could play a crucial role in regulating follicle atresia...
February 26, 2018: Biological Research
https://www.readbyqxmd.com/read/29422438/effect-of-luteinizing-hormone-on-goat-theca-cell-apoptosis-and-steroidogenesis-through-activation-of-the-pi3k-akt-pathway
#16
Xiaomei Wang, Pengda Zou, Yuanyuan He, Kai Meng, Fusheng Quan, Yong Zhang
Luteinizing hormone (LH) is a glycoprotein that regulates the function of ovarian follicular cells. Theca cells (TCs) also have a key role in follicular growth and atresia. The effects and intracellular signaling mechanisms were investigated of LH on apoptosis and steroidogenesis in goat gonadotropin-independent follicular (1.0-4.0 mm) TCs. The results indicated that LH increased androstenedione secretion and relative abundance of CYP17A1 and BCL2 mRNA in the TCs, whereas LH in combination with LY294002, a PI3K/AKT inhibitor, decreased LH-induced function...
March 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29402772/ablation-of-the-mir-17-92-microrna-cluster-in-germ-cells-causes-subfertility-in-female-mice
#17
Jian Wang, Bo Xu, Geng G Tian, Tao Sun, Ji Wu
BACKGROUND/AIMS: Oogenesis is a highly complex process that is intricately regulated by interactions of multiple genes and signaling molecules. However, the underlying molecular mechanisms are poorly understood. There is emerging evidence that microRNAs contribute to oogenesis. Here, we aimed to investigate the role of miR-17-92 cluster in regulating oogenesis. METHODS: The miR-17-92 cluster was genetically ablated in germ cells of female mice by applying the Cre-loxp system for conditional gene knockout...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29386068/effects-of-hpmscs-on-granulosa-cell-apoptosis-and-amh-expression-and-their-role-in-the-restoration-of-ovary-function-in-premature-ovarian-failure-mice
#18
Hongqin Zhang, Qianqian Luo, Xueyan Lu, Na Yin, Dongli Zhou, Lianshuang Zhang, Wei Zhao, Dong Wang, Pengchao Du, Yun Hou, Yan Zhang, Wendan Yuan
BACKGROUND: This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone receptor (FSHR) expression in autoimmune drug-induced premature ovarian failure (POF) mice. The aim of this research is to investigate the mechanisms of hPMSCs on ovarian reserve capacity. METHODS: The POF mice model was established by injection of zona pellucida 3 peptide (pZP3)...
January 31, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29380011/effects-of-bisphenol-a-on-ovarian-follicular-development-and-female-germline-stem-cells
#19
Xiaoqin Zhu, Geng G Tian, Baoli Yu, Yanzhou Yang, Ji Wu
Bisphenol A (BPA), one of the most frequently detected emerging pollutants in the environment, has been implicated in adverse effects in male and female reproduction at extremely low concentrations. This study aimed to investigate the effects and potential mechanism of BPA on mouse ovarian follicular development and female germline stem cells (FGSCs). Female CD-1 adult mice were administered gradient concentrations of BPA (12.5, 25, and 50 mg/kg/day) by intraperitoneal injection. We found that the number of atretic ovarian follicles was significantly increased at high BPA concentrations...
April 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29378329/mir-1275-controls-granulosa-cell-apoptosis-and-estradiol-synthesis-by-impairing-lrh-1-cyp19a1-axis
#20
Jiying Liu, Xinyu Li, Yong Yao, Qiqi Li, Zenxiang Pan, Qifa Li
miR-1275 is one of the microRNAs (miRNAs) that are differentially expressed during follicular atresia in pig ovaries, as identified by a miRNA microarray assay in our previous study [1]. However, its functions in follicular atresia remain unknown. In this study, we showed that miR-1275 promotes early apoptosis of porcine granulosa cells (pGCs) and the initiation of follicular atresia, and inhibits E2 release and expression of CYP19A1, the key gene in E2 production. Bioinformatics and luciferase reporter assays revealed that liver receptor homolog (LRH)-1, not CYP19A1, is a direct functional target of miR-1275...
March 2018: Biochimica et Biophysica Acta
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