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https://www.readbyqxmd.com/read/29055259/functional-impairment-in-adult-bipolar-disorder-with-adhd
#1
Imma Torres, Marina Garriga, Brisa Sole, Caterina M Bonnín, Montse Corrales, Esther Jiménez, Eva Sole, Josep A Ramos-Quiroga, Eduard Vieta, Jose M Goikolea, Anabel Martínez-Aran
BACKGROUND: It is well established that patients with either bipolar disorder (BD) or attention-deficit/hyperactivity disorder (ADHD) present functional impairment even when in remission. Nevertheless, research on functional impairment with adult patients with bipolar disorder comorbid to ADHD (BD+ADHD) is very scarce. The main objective of the current report was to evaluate the overall and specific domains of functioning, in patients with BD+ADHD compared to patients with pure bipolar disorder (pBD) and healthy controls (HCs)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29054935/familial-history-aggregation-on-acute-appendicitis
#2
Francesc Simó Alari, Israel Gutierrez, Judit Gimenéz Pérez
Appendectomy is the most commonly performed surgical procedure, affecting 1%-8% of the paediatric population, with a total 7% lifetime risk, most likely in adolescents and young adults.A case of familial aggregation was reported in our hospital in a family composed of nine siblings from which six of them (66.6%) had been treated of acute appendicitis, five of them in our centre.Many factors have been described as predisposing to appendicitis. Several studies have highlighted the influence of genes in the evolution of this disease and its severity, demonstrating a relative risk increase by three when family history is present...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054751/ng2-cspg4-and-progranulin-in-the-posttraumatic-glial-scar
#3
REVIEW
Michael K E Schäfer, Irmgard Tegeder
Traumatic injury of the central nervous system is one of the leading causes of death and disability in young adults. Failure of regeneration is caused by autonomous neuronal obstacles and by formation of the glial scar, which is essential to seal the injury but also constitutes a barrier for regrowing axons. The scar center is highly inflammatory and populated by NG2+ glia, whereas astrocytes form the sealing border and trap regrowing axons, suggesting that the non-permissive environment of activated astrocytes and extracellular matrix components is one of the reasons for the regenerative failure...
October 17, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29054387/the-post-natal-development-of-intraocular-pressure-in-normal-domestic-cats-felis-catus-and-in-feline-congenital-glaucoma
#4
Sara Adelman, Daniel Shinsako, Julie A Kiland, Vincent Yaccarino, N Matthew Ellinwood, Gil Ben-Shlomo, Gillian J McLellan
Intraocular pressure (IOP) is the most consistent risk factor for progressive vision loss in glaucoma. Cats with recessively inherited feline congenital glaucoma (FCG) exhibit elevated IOP with gradual, painless progression of glaucoma similar to humans and are studied as a model of glaucoma in humans and animals. Here, post-natal development of IOP was characterized in normal domestic cats and in cats with FCG caused by a homozygous LTBP2 mutation. Rebound tonometry (TonoVet(®), ICare Oy, Finland) was used to measure IOP non-invasively, 2-3 times weekly in 63 FCG and 33 normal kittens, of both sexes, from eyelid opening until 3-6 months of age...
October 17, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29054340/the-transmission-of-family-food-and-mealtime-practices-from-adolescence-to-adulthood-longitudinal-findings-from-project-eat-iv
#5
Allison Watts, Jerica M Berge, Katie Loth, Nicole Larson, Dianne Neumark-Sztainer
OBJECTIVE: To determine whether family food and mealtime practices experienced in adolescence are carried forward into parenthood. DESIGN: Baseline (Project Eating and Activity in Teens and Young Adults [EAT]-I) and 15-year follow-up (EAT-IV) survey data from a population-based cohort study (Project EAT). PARTICIPANTS: Cohort members identified as parents at follow-up (n = 727). To gain additional data about the practices of both parents in the household, significant others completed surveys at EAT-IV (n = 380)...
October 17, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29054132/measuring-mental-workload-ocular-astigmatism-aberration-as-a-novel-objective-index
#6
Raimundo Jiménez, David Cárdenas, Rosario G Anera, José R Jiménez, Jesús Vera
This study assessed the effect of two perceptually matched mental tasks with different levels of mental demand on ocular aberrations in a group of young adults. We measured ocular aberration with a wave-front sensor, and total, internal, and corneal RMS (root mean square) aberrations were calculated from Zernike coefficients, considering natural and scaled pupils (5, 4.5, and 4 mm). We found that total, internal, and corneal astigmatism RMS showed significant differences between mental tasks with natural pupils (p<...
October 20, 2017: Ergonomics
https://www.readbyqxmd.com/read/29054031/mental-health-of-heroin-users-with-differing-injection-drug-use-histories-a-non-treatment-sample-of-mexican-american-young-adult-men
#7
Kathryn M Nowotny, Tasha Perdue, Alice Cepeda, Avelardo Valdez
BACKGROUND: While the comorbidity of mental health and injecting heroin has been documented, current research is limited by describing the mental health of people who inject drugs without a comparison group and by the lack of research on nontreatment samples in the United States, particularly among Hispanics. The purpose of this study was to examine the association of injecting history (never, former, occasional, and daily) and multiple outcomes of global and mental health using a sample of U...
October 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29053980/incident-mental-disorders-in-the-aftermath-of-traumatic-events-a-prospective-longitudinal-community-study
#8
Eva Asselmann, Hans-Ulrich Wittchen, Roselind Lieb, Axel Perkonigg, Katja Beesdo-Baum
BACKGROUND: Few strictly prospective-longitudinal community studies examined the role of traumatic events for risk of developing a broad range of incident mental disorders over several years. METHOD: A representative community sample of adolescents and young adults (n = 2797, baseline age 14-24) was prospectively examined in up to three assessment waves over up to 10 years. Traumatic events and DSM-IV mental disorders were assessed at each wave using the DIA-X/M-CIDI...
October 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053909/impact-of-ledipasvir-sofosbuvir-on-the-work-productivity-of-genotype-1-chronic-hepatitis-c-patients-in-asia
#9
Zobair M Younossi, Henry Lik Yuen Chan, Yock Young Dan, Mei Hsuan Lee, Young-Suk Lim, Eliza Kruger, Seng Chuen Tan
Chronic, untreated hepatitis C virus (HCV) infection is associated with a poor clinical prognosis and a detrimental impact on patients' lives, including on work productivity. To estimate the value of productivity losses due to genotype 1 (GT1) HCV infection in Hong Kong, Singapore, South Korea and Taiwan and to estimate the potential productivity gains associated with treating patients with ledipasvir/sofosbuvir (LDV/SOF) therapy,an economic model was developed with a time horizon of one year. HCV patients entered the model at 12 weeks post-treatment, having achieved or not achieved sustained virological response (SVR)...
October 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29053891/look-beyond-the-door-not-through-the-keyhole-evidence-from-a-cognitive-assessment-including-social-cognition-evaluation-in-multiple-sclerosis
#10
EDITORIAL
Antonio Carotenuto
Multiple sclerosis (MS) is a neurological disorder leading to both physical and cognitive disability in young adults. These limitations harshly impact the overall subject's habits and are predictive of poor social integration, resulting in reduced working activity and limited social network [1]. To this point, among the cognitive domains that could be impaired in MS, Social Cognition (SC) can have a direct impact on this outcome, due to its involvement in social interactions. This article is protected by copyright...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053810/associations-between-cellular-aging-markers-and-metabolic-syndrome-findings-from-the-cardia-study
#11
Dóra Révész, Josine E Verhoeven, Martin Picard, Jue Lin, Stephen Sidney, Elissa S Epel, Brenda W J H Penninx, Eli Puterman
Background: Metabolic syndrome (MetS) is thought to promote biological aging, which might lead to cardiovascular and aging-related complications. This large-scale study investigated longitudinal relationships between MetS, its components, and cellular aging markers: leukocyte mitochondrial DNA copy number (mtDNAcn) and telomere length (TL). Methods: We included 989 participants from the Coronary Artery Risk Development in Young Adults Study. MtDNAcn (CARDIA Years 15, 25) and TL (Y15, Y20, Y25) were measured using quantitative PCR...
October 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29053727/impaired-glucose-metabolism-in-subjects-with-the-williams-beuren-syndrome-a-five-year-follow-up-cohort-study
#12
Maria Elena Lunati, Maria Francesca Bedeschi, Veronica Resi, Valeria Grancini, Eva Palmieri, Simona Salera, Faustina Lalatta, Giuseppe Pugliese, Emanuela Orsi
OBJECTIVE: The Williams-Beuren syndrome (WS) is associated with impaired glucose metabolism (IGM) early in adulthood. However, the pathophysiology of IGM remains poorly defined, due to the lack of longitudinal studies investigating the contribution of β-cell dysfunction and impaired insulin sensitivity. This study aimed at assessing incidence of IGM and the underlying mechanisms in WS adults. METHODS: This observational, longitudinal (5-year), cohort study enrolled thirty-one consecutive WS subjects attending a tertiary referral center...
2017: PloS One
https://www.readbyqxmd.com/read/29053714/atopic-asthmatic-immune-phenotypes-associated-with-airway-microbiota-and-airway-obstruction
#13
Benjamin A Turturice, Halvor S McGee, Brian Oliver, Melissa Baraket, Brian T Nguyen, Christian Ascoli, Ravi Ranjan, Asha Rani, David L Perkins, Patricia W Finn
BACKGROUND: Differences in asthma severity may be related to inflammation in the airways. The lower airway microbiota has been associated with clinical features such as airway obstruction, symptom control, and response to corticosteroids. OBJECTIVE: To assess the relationship between local airway inflammation, severity of disease, and the lower airway microbiota in atopic asthmatics. METHODS: A cohort of young adult, atopic asthmatics with intermittent or mild/moderate persistent symptoms (n = 13) were assessed via bronchoscopy, lavage, and spirometry...
2017: PloS One
https://www.readbyqxmd.com/read/29053654/retrospective-analysis-of-jaw-biopsies-in-young-adults-a-study-of-1599-cases-in-southern-brazil
#14
K Silva, A Alves, M Correa, A Etges, A-C Vasconcelos, A-P Gomes, S Tarquinio
BACKGROUND: To evaluate the prevalence and the characteristics of jaw lesions diagnosed in young adults aged 20 to 30 years in a southern Brazil reference center, over a period of 25 years. And to analyze the concordance between clinical and histological diagnosis. MATERIAL AND METHODS: In this cross-sectional retrospective study, the biopsies files from this center were retrieved and data regarding sex, age, bone localization, clinical and histological diagnosis were collected...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29053649/oral-and-oropharyngeal-squamous-cell-carcinoma-in-young-adults-a-retrospective-study-in-granada-university-hospital
#15
P Cariati, A Cabello-Serrano, M Perez-de Perceval-Tara, F Monsalve-Iglesias
BACKGROUND: This study aims to evaluate and analyze the clinical features and outcomes of oral and oropharyngeal squamous cell carcinoma (SCC) in patients < 45-years old in our center. MATERIAL AND METHODS: A retrospective analysis was conducted using the records of patients diagnosed with oral and oropharyngeal SCC between 1998 and 2011 in the University Hospital of Granada (Spain). The analysis identified 33 patients with oral and oropharyngeal SCC with an age of <45 years...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29053023/n-acetylcysteine-for-nonsuicidal-self-injurious-behavior-in-adolescents-an-open-label-pilot-study
#16
Kathryn R Cullen, Bonnie Klimes-Dougan, Melinda Westlund Schreiner, Patricia Carstedt, Nicholas Marka, Katharine Nelson, Michael J Miller, Kristina Reigstad, Ana Westervelt, Meredith Gunlicks-Stoessel, Lynn E Eberly
BACKGROUND: Nonsuicidal self-injury (NSSI) is common in adolescents and young adults, and few evidence-based treatments are available for this significant problem. N-acetylcysteine (NAC) is a widely available nutritional supplement that has been studied in some psychiatric disorders relevant to NSSI including mood and addictive disorders. This pilot study tested the use of NAC as a potential treatment for NSSI in youth. METHODS: Thirty-five female adolescents and young adults with NSSI aged 13-21 years were enrolled in this study that had an open-label, single-arm study design...
October 20, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29052972/impaired-intestinal-barrier-function-and-relapsing-digestive-disease-lessons-from-a-porcine-model-of-early-life-stress
#17
REVIEW
A L Ziegler, A T Blikslager
Within this issue of Neurogastroenterology and Motility, an article by Pohl et al highlights new insights from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders. Early weaning stress closely mimics the early life psychosocial stressors that have been linked to adult onset gastrointestinal dysfunction. This early weaning model provides reproducible and highly translatable outcomes in young stress-challenged pigs. Due to the convincingly comparable neurological and gastroenterological anatomy and physiology between pigs and human beings, gastrointestinal stress and injury studies utilizing swine models will provide invaluable insights to improve our understanding and treatment of gastrointestinal disease in human beings...
November 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29052952/factor-structure-of-the-cannabis-experiences-questionnaire-in-a-first-episode-psychosis-sample
#18
Michael L Birnbaum, Sean D Cleary, Claire Ramsay Wan, Luca Pauselli, Michael T Compton
AIM: The Cannabis Experiences Questionnaire (CEQ) was developed to measure the subjective experiences of cannabis use both during and after intoxication. Despite the need to better understand the nature of the complex and significant relationship between cannabis use and early psychosis, this questionnaire has rarely been used in individuals with first-episode psychosis. METHODS: We conducted a set of factor analyses using CEQ data from 194 first-episode psychosis patients who used cannabis in order to uncover the underlying factor structure of the questionnaire and thus the overarching types of psychological experiences during/after using cannabis in young people with psychotic disorders...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29052947/exploring-opportunities-to-support-mental-health-care-using-social-media-a-survey-of-social-media-users-with-mental-illness
#19
John A Naslund, Kelly A Aschbrenner, Gregory J McHugo, Jürgen Unützer, Lisa A Marsch, Stephen J Bartels
AIM: Social media holds promise for expanding the reach of mental health services, especially for young people who frequently use these popular platforms. We surveyed social media users who self-identified as having a mental illness to learn about their use of social media for mental health and to identify opportunities to augment existing mental health services. METHODS: We asked 240 Twitter users who self-identified in their profile as having a mental illness to participate in an online survey...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29052865/research-review-is-anxiety-associated-with-negative-interpretations-of-ambiguity-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#20
REVIEW
Suzannah Stuijfzand, Cathy Creswell, Andy P Field, Samantha Pearcey, Helen Dodd
BACKGROUND: The tendency to interpret ambiguity as threat (negative interpretation) has been implicated in cognitive models of anxiety. A significant body of research has examined the association between anxiety and negative interpretation, and reviews suggest there is a robust positive association in adults. However, evidence with children and adolescents has been inconsistent. This study aimed to provide a systematic quantitative assessment of the association between anxiety and negative interpretation in children and adolescents...
October 20, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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