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https://www.readbyqxmd.com/read/28650971/a-lab-on-phone-instrument-with-varifocal-microscope-via-a-liquid-actuated-aspheric-lens-lal
#1
Yiin-Kuen Fuh, Zheng-Hong Lai, Li-Han Kau, Hung-Jui Huang
In this paper, we introduce a novel concept of liquid-actuated aspheric lens (LAL) with a built-in aspheric polydimethylsiloxane lens (APL) to enable the design of compact optical systems with varifocal microscopic imaging. The varifocal lens module consists of a sandwiched structures such as 3d printed syringe pump functionally serves as liquid controller. Other key components include two acrylic cylinders, a rigid separator, a APL/membrane composite (APLMC) embedded PDMS membrane. In functional operation, the fluidic controller was driven to control the pressure difference and ALPMC deformation...
2017: PloS One
https://www.readbyqxmd.com/read/28650970/point-of-care-testing-for-toxoplasma-gondii-igg-igm-using-toxoplasma-ict-igg-igm-test-with-sera-from-the-united-states-and-implications-for-developing-countries
#2
Ian J Begeman, Joseph Lykins, Ying Zhou, Bo Shiun Lai, Pauline Levigne, Kamal El Bissati, Kenneth Boyer, Shawn Withers, Fatima Clouser, A Gwendolyn Noble, Peter Rabiah, Charles N Swisher, Peter T Heydemann, Despina G Contopoulos-Ioannidis, Jose G Montoya, Yvonne Maldonado, Raymund Ramirez, Cindy Press, Eileen Stillwaggon, François Peyron, Rima McLeod
BACKGROUND: Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved. METHODS: We tested 180 sera with the Toxoplasma ICT IgG-IgM point-of-care (POC) test. Sera were from 116 chronically infected persons (48 serotype II; 14 serotype I-III; 25 serotype I-IIIa; 28 serotype Atypical, haplogroup 12; 1 not typed)...
June 26, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28650611/integrating-target-responsive-hydrogel-with-pressuremeter-readout-enables-simple-sensitive-user-friendly-quantitative-point-of-care-testing
#3
Dan Liu, Shasha Jia, Huimin Zhang, Yanli Ma, Zhichao Guan, Jiuxing Li, Zhi Zhu, Tianhai Ji, Chaoyong James Yang
Point-of-care testing (POCT) with the advantages of speed, simplicity, and low cost, as well as no need for instrumentation is critical for the measurement of analytes in a variety of environments lacking access to laboratory infrastructure. In the present study, a hydrogel pressure-based assay for quantitative POCT was developed by integrating a target-responsive hydrogel with pressuremeter readout. The target-responsive hydrogels were constructed with DNA grafted linear polyacrylamide and the crosslinking DNA for selective target recognition...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28650005/sub-picomolar-label-free-detection-of-thrombin-using-electrochemical-impedance-spectroscopy-of-aptamer-functionalized-mos2
#4
Kai-Chun Lin, Badrinath Jagannath, Sriram Muthukumar, Shalini Prasad
An ultrasensitive aptasensor for the label free non-faradaic detection of thrombin has been demonstrated on molybdenum disulphide (MoS2) nanosheets. These nanosheets were physiochemically immobilized onto a silicon micro-electrode platform. Thrombin detection was achieved through the charge modulation of the electrical double layer due to the specific and dose dependent binding of thrombin to the surface of thiol terminated ssDNA aptamer functionalized MoS2 nanosheets. Electrical double layer charge modulation associated with thrombin binding was characterized using electrochemical impedance spectroscopy...
June 26, 2017: Analyst
https://www.readbyqxmd.com/read/28649724/evaluation-of-the-uriscan-2-acr-strip-to-estimate-the-urine-albumin-creatinine-ratios
#5
Sangeun Lim, Hui-Jin Yu, Seungjun Lee, Hyosoon Park, Min-Jung Kwon, Hee-Yeon Woo
BACKGROUND: The urine albumin/creatinine ratio (ACR) test is used to screen patients with chronic diseases, such as diabetes, hypertension and cardiovascular diseases that put them at an increased risk of developing kidney disease. Here, we evaluated the performance of the URiSCAN 2 ACR Strip (URiSCAN; YD diagnostics, Yongin, Korea), a semiquantitative point-of-care testing (POCT) assay, and we compared to an existing POCT assay and a quantitative assay. MATERIALS AND METHODS: A total of 1,020 random urine specimens were analyzed using the semiquantitative URiSCAN 2 ACR Strip and semiquantitative CLINITEK Microalbumin 2 Strip (CLINITEK; Siemens, New York, USA)...
June 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28649711/point-of-care-ultrasound-in-general-surgery-residency-training-a-proposal-for-milestones-in-graduate-medical-education-ultrasound
#6
Eliza W Beal, Benjamin R Sigmond, Latifa Sage-Silski, Samantha Lahey, Victor Nguyen, David P Bahner
The use of point-of-care ultrasound (US) in the clinical setting has undergone massive growth, although its incorporation into training and practice is variable. Surgeons are interested in using point-of-care US and can incorporate it effectively into clinical practice. However, the current state of point-of-care US training in general surgery is inadequate. The Accreditation Council for Graduate Medical Education introduced the Milestones Project to evaluate resident and fellow performance. Emergency medicine is the only specialty with a point-of-care US milestone...
June 26, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28649484/enhancing-the-angular-sensitivity-of-plasmonic-sensors-using-hyperbolic-metamaterials
#7
Kandammathe Valiyaveedu Sreekanth, Yunus Alapan, Mohamed ElKabbash, Amy M Wen, Efe Ilker, Michael Hinczewski, Umut A Gurkan, Nicole F Steinmetz, Giuseppe Strangi
Surface plasmon resonance (SPR) sensors operate mainly on prism and grating coupling techniques, with spectral and angular scans being the two major interrogation schemes. Among them, the angular scan technique has several advantages including higher measurement precision owing to its higher signal-to-noise ratio. The currently available SPR sensor arrangements provide a maximum angular sensitivity of 500°-600° per RIU. Here, we report the study of grating coupled-hyperbolic metamaterial (GC-HMM) sensors with high angular sensitivity...
November 2016: Advanced Optical Materials
https://www.readbyqxmd.com/read/28649026/proximity-hybridization-regulated-electrogenerated-chemiluminescence-bioassay-of-%C3%AE-fetoprotein-via-target-induced-quenching-mechanism
#8
Hongfang Gao, Xiaofei Wang, Man Li, Honglan Qi, Qiang Gao, Chengxiao Zhang
A proximity hybridization-regulated electrogenerated chemiluminescence (PLA-ECL) bioassay was developed for the detection of α-fetoprotein (AFP) on basis of the sensitization of gold nanoparticles (AuNPs) and target-induced quenching mechanism. Ru(bpy)3(2+) was used as ECL signal while ferrocene (Fc) was used as ECL quencher. Ru(bpy)3(2+) was electrostatically adsorbed into the AuNPs/Nafion film prepared by casting the mixture of Nafion and AuNPs onto the surface of glassy carbon electrode (GCE) to form an ECL platform (Ru(bpy)3(2+)/AuNPs/Nafion/GCE), which displayed strong ECL emissions...
June 21, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28649024/microfluidic-platform-integrated-with-graphene-gold-nano-composite-aptasensor-for-one-step-detection-of-norovirus
#9
Rohit Chand, Suresh Neethirajan
Noroviruses are a foremost cause of gastroenteritis outbreaks throughout the world. On-site sample processing and detection of the viral clinical samples has always been a problem. This study reports an all-polydimethylsiloxane microfluidic chip integrated with screen-printed carbon electrode for the electrochemical detection of norovirus. The microfluidic chip contained packed silica microbeads zones to filter and enrich the norovirus infected clinical sample. Selective detection of norovirus was accomplished by functionalizing the graphene-gold nanoparticles composite modified carbon electrode with the viral capsid-specific aptamer...
June 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28649023/stability-enhanced-repeatability-improved-parylene-c-passivated-on-qcm-sensor-for-aptt-measurement
#10
Yuchen Yang, Wei Zhang, Zhen Guo, Zhiqi Zhang, Hongnan Zhu, Ruhong Yan, Lianqun Zhou
Determination of blood clotting time is essential in monitoring therapeutic anticoagulants. In this work, Parylene-C passivated on quartz crystal microbalance (P-QCM) was developed for the activated partial thromboplastin time (aPTT) measurement. Compared with typical QCM, P-QCM possessed a hydrophobic surface and sensitive frequency response to viscoelastic variations on electrode surface. Fibrin could be adsorbed effectively, due to the hydrophobicity of the P-QCM surface. Comparing with typical QCM, the peak-to-peak value (PPV) of P-QCM was increased by 1...
June 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28648871/creation-of-an-open-framework-for-point-of-care-computer-assisted-reporting-and-decision-support-tools-for-radiologists
#11
Tarik K Alkasab, Bernardo C Bizzo, Lincoln L Berland, Sujith Nair, Pari V Pandharipande, H Benjamin Harvey
Decreasing unnecessary variation in radiology reporting and producing guideline-concordant reports is fundamental to radiology's success in value-based payment models and good for patient care. In this article, we present an open authoring system for point-of-care clinical decision support tools integrated into the radiologist reporting environment referred to as the computer-assisted reporting and decision support (CAR/DS) framework. The CAR/DS authoring system, described herein, includes: (1) a definition format for representing radiology clinical guidelines as structured, machine-readable Extensible Markup Language documents and (2) a user-friendly reference implementation to test the fidelity of the created definition files with the clinical guideline...
June 22, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28646991/understanding-the-immune-signature-fingerprint-of-peritoneal-dialysis-related-peritonitis
#12
Tadashi Takeuchi, Hiroshi Ohno, Naoko Satoh-Takayama
Although acute peritonitis is a common and severe complication associated with peritoneal dialysis, the culture-based test used as the diagnostic criterion for this disease is often too slow to allow appropriate point-of-care diagnosis of specific bacterial infection. To address this problem, Zhang et al. report the efficacy of a novel set of immune biomarkers derived from a machine-learning algorithm applied to patient data. This fingerprint could predict major pathogenic causes of peritonitis.
July 2017: Kidney International
https://www.readbyqxmd.com/read/28646719/dna-aptamer-based-colorimetric-detection-platform-for-salmonella-enteritidis
#13
Ceren Bayraç, Füsun Eyidoğan, Hüseyin Avni Öktem
Food safety is a major issue to protect public health and a key challenge is to find detection methods for identification of hazards in food. Food borne infections affects millions of people each year and among pathogens, Salmonella Enteritidis is most widely found bacteria causing food borne diseases. Therefore, simple, rapid, and specific detection methods are needed for food safety. In this study, we demonstrated the selection of DNA aptamers with high affinity and specificity against S. Enteritidis via Cell Systematic Evolution of Ligands by Exponential Enrichment (Cell-SELEX) and development of sandwich type aptamer-based colorimetric platforms for its detection...
June 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28646627/collecting-validity-evidence-for-simulation-based-assessment-of-point-of-care-ultrasound-skills
#14
Jesper Kørup Jensen, Liv Dyre, Mattis Enggaard Jørgensen, Lisbeth Anita Andreasen, Martin Grønnebaek Tolsgaard
OBJECTIVES: The aim of this study was to examine the validity of a simulator test designed to evaluate focused assessment with sonography for trauma (FAST) skills. METHODS: Participants included a group of ultrasound novices (n = 25) and ultrasound experts (n = 10). All participants had their FAST skills assessed using a virtual reality ultrasound simulator. Procedural performance on the 4 FAST windows was assessed by automated simulator metrics, which received a passing or failing score...
June 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28646595/point-of-care-ultrasound-work-flow-innovation-impact-on-documentation-and-billing
#15
Matthew J Flannigan, Srikar Adhikari
OBJECTIVES: To evaluate the impact that an innovative automated ultrasound (US) work flow, which allows for bedside performance of examination documentation and order placement, has on point-of-care US billing compared to ordering US examinations through an electronic medical record. METHODS: We conducted a retrospective review of point-of-care US billing data (March 2014-February 2016) for adult and pediatric emergency departments with an emergency medicine residency and a US fellowship...
June 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28644046/paper-based-point-of-care-testing-in-disease-diagnostics
#16
Leila Syedmoradi, Frank A Gomez
No abstract text is available yet for this article.
June 23, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28643228/a-urologic-stethoscope-urologist-performed-sonography-using-a-pocket-size-ultrasound-device-in-the-point-of-care-setting
#17
Arnon Lavi, Sharon Tzemah, Anan Hussein, Ibrahim Bishara, Nikolay Shcherbakov, Genady Zelichenko, Alon Mashiah, Michael Gross, Leonid Cherbinski, Ziv Neeman, Michael Cohen
PURPOSE: Ultrasound is commonly used in urology. Technical advances with reduced size and cost led to diffusion of small ultrasound devices to many clinical settings. Even so, most ultrasound studies are performed by non-urologists. We aimed to evaluate the utility of a pocket-size ultrasound device (Vscan™ GE Healthcare) and the quality of urologist performed study. METHODS: Three consecutive studies were performed: (1) a urologist using the pocket ultrasound, (2) a sonographist using the pocket ultrasound, and (3) a sonographist using a standard ultrasound device...
June 22, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28640133/effectiveness-of-education-in-point-of-care-ultrasound-assisted-physical-examinations-in-an-emergency-department-a-before-and-after-study
#18
Yoo Jin Choi, Jae Yun Jung, Hyuksool Kwon
Implementation of point-of-care ultrasonography (POCUS)-assisted physical examination (PE) in emergency departments (EDs) was conducted in the ED of an urban tertiary teaching hospital. This study examines the effect of POCUS implementation in emergency medicine departments by using a systematic education program on image acquisition to analyze decision making.Educating staff on POCUS involved a technique related to image acquisition and then accurately diagnosing subsequent POCUS results. The quasi-experimental, uncontrolled before-and-after study was performed to evaluate the education effect...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28638663/acute-abdominal-compartment-syndrome-following-extraperitoneal-bladder-perforation
#19
Ana Licina
Extraperitoneal bladder perforation is a known complication of a commonly performed rigid cystoscopy. If unrecognized, this complication can lead to continuous intra-abdominal fluid leakage with consequent organ function impairment and symptoms. This is the first case report in literature of a transurethral bladder perforation causing an acute abdominal compartment syndrome, which was subsequently managed conservatively with supportive management only. Case Presentation. We describe a clinical course of a 73-year-old Caucasian female whose initial acute presentation involved urinary symptoms...
2017: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/28638471/rapid-detection-of-avian-influenza-virus-by-fluorescent-diagnostic-assay-using-an-epitope-derived-peptide
#20
Duong Tuan Bao, Do Thi Hoang Kim, Hyun Park, Bui Thi Cuc, Nguyen Minh Ngoc, Nguyen Thi Phuong Linh, Nguyen Chien Huu, Trinh Thi Thuy Tien, Nguyen Thi Viet Anh, Tung Dao Duy, Chom-Kyu Chong, Seung-Taek Yu, Do-Young Choi, Seon-Ju Yeo
Currently, the point of care testing (POCT) is not fully developed for subtype-specific avian influenza virus detection. In this study, an H5N1 hemaglutinin 1 (HA1) epitope (P0: KPNDAINF) and three modified peptides (P1: KPNTAINF, P2: KPNGAINF, P3: KPNDAINDAINF) were evaluated as POCT elements for rapid detection of avian influenza virus. Based on modeling predictions by Autodock Vina, binding affinity varied depending on alteration of one amino acid in these peptides. The binding energy of P2 indicated its potential for a strong interaction with HA...
2017: Theranostics
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