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spasticity in cp

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https://www.readbyqxmd.com/read/29149666/relationship-between-radiographic-patella-alta-pathology-and-walking-dysfunction-in-children-with-bilateral-spastic-cerebral-palsy
#1
Matthias Hösl, Harald Böhm, Michaela Seltmann, Chakravarthy Ugandhar Dussa, Leonhard Döderlein
BACKGROUND: Patella-alta is very common in patients with Cerebral Palsy (CP). While several diagnostic x-ray indices have been developed for patella-alta in general, the specific relationship with walking dysfunction in CP is only partly understood. METHODS: 33 participants with bilateral spastic CP between 4 and 20 years (GMFCS I-II without previous surgery) that underwent 3D gait analysis as well as a radiographic exam within 0.8 (SD 1.2) months were retrospectively included...
November 10, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29149272/use-of-paracetamol-ibuprofen-or-aspirin-in-pregnancy-and-risk-of-cerebral-palsy-in-the-child
#2
Tanja Gram Petersen, Zeyan Liew, Anne-Marie Nybo Andersen, Guro L Andersen, Per Kragh Andersen, Torben Martinussen, Jørn Olsen, Cristina Rebordosa, Mette Christophersen Tollånes, Peter Uldall, Allen J Wilcox, Katrine Strandberg-Larsen
Background: It has been debated whether mild analgesics, mainly paracetamol, adversely affect aspects of neurodevelopment. We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child. Method: We included 185 617 mother-child pairs from the Danish National Birth Cohort and the Norwegian Mother and Child Cohort Study. We created harmonized definitions of analgesic use in pregnancy, as well as indications for analgesic use and other potential confounders...
November 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29148568/intrathecal-baclofen-in-dyskinetic-cerebral-palsy-effects-on-function-and-activity
#3
Meta N Eek, Kristina Olsson, Karin Lindh, Berit Askljung, Magnus Påhlman, Olle Corneliusson, Kate Himmelmann
AIM: To investigate the effect of intrathecal baclofen (ITB) on function and activity in dyskinetic cerebral palsy (CP). METHOD: A retrospective cohort study of records from 25 children (15 males, 10 females; mean age 10y 11mo, SD 4y 9mo). Five were classified in Gross Motor Function Classification level IV and 20 in level V. Parents were interviewed about activities in daily life, sitting, communication, pain, sleep, and gross and fine motor function. Differences before and 1 year after ITB were graded as positive, no change, or negative...
November 17, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29148138/artificial-walking-technologies-to-improve-gait-in-cerebral-palsy-multichannel-neuromuscular-stimulation
#4
Jessica Rose, Katelyn Cahill-Rowley, Erin E Butler
Cerebral palsy (CP) is the most common childhood motor disability and often results in debilitating walking abnormalities, such as flexed-knee and stiff-knee gait. Current medical and surgical treatments are only partially effective in improving gait abnormalities and may cause significant muscle weakness. However, emerging artificial walking technologies, such as step-initiated, multichannel neuromuscular electrical stimulation (NMES), can substantially improve gait patterns and promote muscle strength in children with spastic CP...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29146092/ultrasonographic-evaluation-of-changes-in-the-muscle-architecture-of-the-gastrocnemius-with-botulinum-toxin-treatment-for-lower-extremity-spasticity-in-children-with-cerebral-palsy
#5
Akihiro Kawano, Taiichiro Yanagizono, Ichiro Kadouchi, Tetsuya Umezaki, Etsuo Chosa
BACKGROUND: Botulinum toxin A treatment involves injecting botulinum toxin A to relax muscle spasticity. Using ultrasonography, this study examined changes in the muscle architecture before and after treatment to evaluate the influence of botulinum toxin A injection on muscles. METHODS: The participants included 18 children (mean age, 6.2 years) with cerebral palsy who were treated with botulinum toxin A for lower extremity spasticity and 27 healthy children (mean age, 6...
November 13, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29145580/effect-of-botulinum-toxin-a-on-muscle-healing-and-its-implications-in-aesthetic-and-reconstructive-surgery
#6
Eldad Silberstein, Ehud Maor, Oleg Sukmanov, Alexander Bogdanov Berezovsky, Yaron Shoham, Yuval Krieger
Background: Muscle activity contributes to the enhancement of facial aging deformity, blepharospasm, cerebral palsy spasticity, trismus, torticollis, and other conditions. Myotomy of the involved muscles in order to reduce the deformity has variable success rates due to muscle healing and regeneration of activity. Objectives: The goal of this study was to investigate whether blocking striated muscle activity with Botulinum toxin (BtxA) during the healing time after myotomy alters the healing process and reduces long-term muscle activity...
November 14, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29135566/management-of-hypertonia-in-cerebral-palsy
#7
Nickolas J Nahm, H Kerr Graham, Mark E Gormley, Andrew G Georgiadis
PURPOSE OF REVIEW: The review provides an update on the treatment of hypertonia in cerebral palsy, including physical management, pharmacotherapy, neurosurgical, and orthopedic procedures. RECENT FINDINGS: Serial casting potentiates the effect of Botulinum neurotoxin A injections for spasticity. Deep brain stimulation, intraventricular baclofen, and ventral and dorsal rhizotomy are emerging tools for the treatment of dystonia and/or mixed tone. The long-term results of selective dorsal rhizotomy and the timing of orthopedic surgery represent recent advances in the surgical management of hypertonia...
November 11, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29123343/multiple-nutritional-deficiencies-in-cerebral-palsy-compounding-physical-and-functional-impairments
#8
P G Hariprasad, K E Elizabeth, Mathew J Valamparampil, D Kalpana, T S Anish
Introduction: Cerebral palsy (CP) refers to a spectrum of disorders causing physical and intellectual morbidity. Macro and micro nutrient deficiencies often contribute to the subnormal physical and mental capabilities of them. Objectives: To assess the growth, nutritional status, physical and functional ability and quality of life in cerebral palsy children and to determine any relation with their gross motor and functional capabilities. Method: The study was conducted at a Tertiary Care Centre, with the participants in the age group 1-16 years...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29116382/selective-dorsal-rhizotomy-for-the-treatment-of-severe-spastic-cerebral-palsy-efficacy-and-therapeutic-durability-in-gmfcs-grade-iv-and-v-children
#9
Daniel D'Aquino, Ahmad A Moussa, Amr Ammar, Harshal Ingale, Michael Vloeberghs
BACKGROUND: Selective dorsal rhizotomy (SDR) has been established as an effective surgical treatment for spastic diplegia. The applicability of SDR to the full spectrum of spastic cerebral palsy and the durability of its therapeutic effects remain under investigation. There are currently limited data in the literature regarding efficacy and outcomes following SDR in Gross Motor Function Classification System (GMFCS) IV and V patients. Intrathecal baclofen has traditionally been the surgical treatment of choice for these patients...
November 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29102350/prevalence-of-cerebral-palsy-in-uganda-a-population-based-study
#10
Angelina Kakooza-Mwesige, Carin Andrews, Stefan Peterson, Fred Wabwire Mangen, Ann Christin Eliasson, Hans Forssberg
BACKGROUND: Few population-based studies of cerebral palsy have been done in low-income and middle-income countries. We aimed to examine cerebral palsy prevalence and subtypes, functional impairments, and presumed time of injury in children in Uganda. METHODS: In this population-based study, we used a nested, three-stage, cross-sectional method (Iganga-Mayuge Health and Demographic Surveillance System [HDSS]) to screen for cerebral palsy in children aged 2-17 years in a rural eastern Uganda district...
October 25, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29100187/mechanical-muscle-and-tendon-properties-of-the-plantar-flexors-are-altered-even-in-highly-functional-children-with-spastic-cerebral-palsy
#11
Annika Kruse, Christian Schranz, Martin Svehlik, Markus Tilp
BACKGROUND: Recent ultrasound studies found increased passive muscle stiffness and no difference in tendon stiffness in highly impaired children and young adults with cerebral palsy. However, it is not known if muscle and tendon mechanical properties are already altered in highly functional children with cerebral palsy. Therefore, the purpose of this study was to compare the mechanical and material properties of the plantar flexors in highly functional children with cerebral palsy and typically developing children...
October 28, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29072043/evaluation-of-a-self-administered-transcutaneous-electrical-stimulation-concept-for-the-treatment-of-spasticity-a-randomised-placebo-controlled-trial
#12
Per Ertzgaard, Jenny Alwin, Ann Sörbo, Marie Lindgren, Leif Sandsjö
BACKGROUND: Spasticity is a common consequence of injury to the central nervous system negatively affecting patient's everyday activities. Treatment mainly consists of training and different drugs, often with side effects. There is a need for treatment options that can be performed by the patient in their home environment. AIM: The objective of this study was to assess the effectiveness of an assistive technology (AT), Mollii®, a garment with integrated electrodes for multifocal transcutaneous electrical stimulation intended for self-treatment of spasticity, in study participants with spasticity due to stroke or CP...
October 25, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29067675/estimating-medial-gastrocnemius-muscle-volume-in-children-with-spastic-cerebral-palsy-a-cross-sectional-investigation
#13
Simon-Henri Schless, Britta Hanssen, Francesco Cenni, Lynn Bar-On, Erwin Aertbeliën, Guy Molenaers, Kaat Desloovere
AIM: This cross-sectional investigation evaluates the reliability of estimating medial gastrocnemius anatomical cross-sectional area (aCSA) in typically developing and spastic cerebral palsy (SCP) cohorts. It verifies whether muscle volume estimations based on aCSA improve when aCSA is multiplied by muscle-tendon unit (MTU) or muscle length, and whether the resulting errors in volume estimations are smaller than changes after intervention. METHOD: Fifteen typically developing children (mean age 8y 2mo [SD 1y 5mo], six males, nine females) and 30 children with SCP (mean age 9y 2mo [SD 2y 5mo], 22 males, eight females, Gross Motor Function Classification System [GMFCS] level I=15, II=15) participated in the investigation...
October 24, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29066586/mechanical-insufflation-exsufflation-versus-conventional-chest-physiotherapy-in-children-with-cerebral-palsy
#14
Rasintra Siriwat, Jitladda Deerojanawong, Suchada Sritippayawan, Sumalee Hantragool, Prapasri Cheanprapai
BACKGROUND: The cough mechanism is often impaired in children with quadriplegic spastic cerebral palsy, accounting for the high prevalence of pneumonia and atelectasis requiring prolonged hospitalization. Conventional chest physiotherapy (CPT) is a current technique recommended at the onset of lower-respiratory infections in cerebral palsy. Previous studies have demonstrated the usefulness of mechanical insufflation-exsufflation (MI-E) in children with neuromuscular disease. To date, there has been no study of MI-E in children with quadriplegic spastic cerebral palsy...
October 24, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29066071/altered-regional-and-circuit-resting-state-activity-in-patients-with-occult-spastic-diplegic-cerebral-palsy
#15
Xuetao Mu, Zhiqun Wang, Binbin Nie, Shaofeng Duan, Qiaozhi Ma, Guanghui Dai, Chunnan Wu, Yuru Dong, Baoci Shan, Lin Ma
BACKGROUND: Very few studies have been made to investigate functional activity changes in occult spastic diplegic cerebral palsy (SDCP). The purpose of this study was to analyze whole-brain resting state regional brain activity and functional connectivity (FC) changes in patients with SDCP. METHODS: We examined 12 occult SDCP and 14 healthy control subjects using resting-state functional magnetic resonance imaging. The data were analyzed using Resting-State fMRI Data Analysis Toolkit (REST) software...
October 7, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29060644/antagonist-thigh-muscle-activity-in-6-to-8-year-old-children-assessed-by-surface-emg-during-walking
#16
Francesco Di Nardo, Annachiara Strazza, Alessandro Mengarelli, Serena Ercolani, Laura Burattini, Sandro Fioretti
Analysis of muscle co-contractions seems to be relevant in the characterization of children pathologies such as spastic cerebral palsy. The aim of the study was the quantification of thigh-muscle co-contractions during walking in healthy children. To this aim, the Statistical Gait Analysis, a recent methodology providing a statistical characterization of gait, was performed on surface EMG signals from Vastus Medialis (VM) and Lateral Hamstrings (LH) in 30 healthy 6-to-8-year-old children. Muscular co-contraction was assessed as the overlapping period between activation intervals of agonist and antagonist muscles...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058612/skeletal-muscle-mechanics-energetics-and-plasticity
#17
REVIEW
Richard L Lieber, Thomas J Roberts, Silvia S Blemker, Sabrina S M Lee, Walter Herzog
The following papers by Richard Lieber (Skeletal Muscle as an Actuator), Thomas Roberts (Elastic Mechanisms and Muscle Function), Silvia Blemker (Skeletal Muscle has a Mind of its Own: a Computational Framework to Model the Complex Process of Muscle Adaptation) and Sabrina Lee (Muscle Properties of Spastic Muscle (Stroke and CP) are summaries of their representative contributions for the session on skeletal muscle mechanics, energetics and plasticity at the 2016 Biomechanics and Neural Control of Movement Conference (BANCOM 2016)...
October 23, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29051729/negative-influence-of-motor-impairments-on-upper-limb-movement-patterns-in-children-with-unilateral-cerebral-palsy-a-statistical-parametric-mapping-study
#18
Cristina Simon-Martinez, Ellen Jaspers, Lisa Mailleux, Kaat Desloovere, Jos Vanrenterghem, Els Ortibus, Guy Molenaers, Hilde Feys, Katrijn Klingels
Upper limb three-dimensional movement analysis (UL-3DMA) offers a reliable and valid tool to evaluate movement patterns in children with unilateral cerebral palsy (uCP). However, it remains unknown to what extent the underlying motor impairments explain deviant movement patterns. Such understanding is key to develop efficient rehabilitation programs. Although UL-3DMA has been shown to be a useful tool to assess movement patterns, it results in a multitude of data, challenging the clinical interpretation and consequently its implementation...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29050720/does-intrathecal-baclofen-therapy-increase-prevalence-and-or-progression-of-neuromuscular-scoliosis
#19
Kevin R Walker, Susan A Novotny, Linda E Krach
STUDY DESIGN: Retrospective, case-matched review. OBJECTIVES: Compare a group of individuals with cerebral palsy (CP) who had intrathecal baclofen (ITB) pumps to a group of individuals with CP who did not have ITB pumps in order to determine if there was a difference in the prevalence of new-onset neuromuscular scoliosis, an increased rate of progression of preexisting neuromuscular scoliosis, or an increased rate of posterior spine fusion surgery in skeletally immature individuals with CP who had ITB pumps...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29019475/orofacial-pain-associated-with-vasospastic-angina-a-case-report
#20
Makoto Adachi, Mio Hayashi, Tomonori Segawa, Takahiko Yamaki, Yasunori Muramatsu, Shinichiro Sumitomo
The primary symptom of ischemic heart disease is typically chest pain, but in some cases, this pain may radiate to the maxillofacial region. This article describes the case of a 44-year-old man with orofacial pain of cardiac origin. The patient was suspected to be suffering from cardiac disease by the oral and maxillofacial surgeon and was referred to a cardiologist, where he received a heart examination. The patient was diagnosed by means of cardiac catheterization as having coronary spastic angina. During catheterization, intracoronary ergonovine maleate induced orofacial pain that was almost the same in character and intensity as the patient's first episode...
2017: Journal of Oral & Facial Pain and Headache
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