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RAGE and pain

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https://www.readbyqxmd.com/read/27806160/as-opioid-epidemic-rages-complementary-health-approaches-to-pain-gain-traction
#1
Jennifer Abbasi
No abstract text is available yet for this article.
November 2, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27795710/treatment-of-snoring-with-a-nasopharyngeal-airway-tube
#2
Macario Camacho, Edward T Chang, Camilo Fernandez-Salvador, Robson Capasso
Objective. To study the feasibility of a standard nasopharyngeal airway tube (NPAT) as treatment for snoring. Methods. An obese 35-year-old man, who is a chronic, heroic snorer, used NPATs while (1) the patient's bedpartner scored the snoring and (2) the patient recorded himself with the smartphone snoring app "Quit Snoring." Baseline snoring was 8-10/10 (10 = snoring that could be heard through a closed door and interrupted the bedpartner's sleep to the point where they would sometimes have to sleep separately) and 60-200 snores/hr...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27792788/trem-1-hmgb1-and-rage-in-the-shoulder-tendon-dual-mechanisms-for-inflammation-based-on-the-coincidence-of-glenohumeral-arthritis
#3
Finosh G Thankam, Matthew F Dilisio, Nicholas E Dietz, Devendra K Agrawal
Rotator cuff injury (RCI) is a major musculoskeletal disorder in the adult population where inflammation and pain are major contributing factors. Coincidence of other clinical conditions like glenohumeral arthritis aggravates inflammation and delays the healing response. The mechanism and signaling factors underlying the sustenance of inflammation in the rotator cuff joint are largely unknown. The present article aims to elucidate the involvement of inflammatory molecule, TREM-1 (Triggering Receptors Expressed on Myeloid cells-1), and danger-associated molecular patterns (DAMPs), including high mobility group protein 1 (HMGB-1) and RAGE (receptor for advanced glycation end products), in the setting of RCI with respect to the severity of glenohumeral arthritis...
2016: PloS One
https://www.readbyqxmd.com/read/27760316/hmgb1-activates-proinflammatory-signaling-via-tlr5-leading-to-allodynia
#4
Nabanita Das, Varun Dewan, Peter M Grace, Robin J Gunn, Ryo Tamura, Netanel Tzarum, Linda R Watkins, Ian A Wilson, Hang Yin
Infectious and sterile inflammatory diseases are correlated with increased levels of high mobility group box 1 (HMGB1) in tissues and serum. Extracellular HMGB1 is known to activate Toll-like receptors (TLRs) 2 and 4 and RAGE (receptor for advanced glycation endproducts) in inflammatory conditions. Here, we find that TLR5 is also an HMGB1 receptor that was previously overlooked due to lack of functional expression in the cell lines usually used for studying TLR signaling. HMGB1 binding to TLR5 initiates the activation of NF-κB signaling pathway in a MyD88-dependent manner, resulting in proinflammatory cytokine production and pain enhancement in vivo...
October 18, 2016: Cell Reports
https://www.readbyqxmd.com/read/27696337/the-psycho-neurology-of-cross-species-affective-social-neuroscience-understanding-animal-affective-states-as-a-guide-to-development-of-novel-psychiatric-treatments
#5
Jaak Panksepp
During the past half century of research with preclinical animal models, affective neuroscience has helped identify and illuminate the functional neuroanatomies and neurochemistries of seven primary process, i.e., genetically provided emotional systems of mammalian brains. All are subcortically localized, allowing animal models to guide the needed behavioral and neuroscientific analyses at levels of detail that cannot be achieved through human research, including modern brain imaging. They consist of the following neuronal processes: SEEKING/Enthusiasm, RAGE/Anger, FEAR/Anxiety, sexual LUST/Passion, maternal CARE/Nurturance, separation-distress PANIC/Grief and PLAY/Social Joy...
October 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27652164/identifying-attachment-ruptures-underlying-severe-music-performance-anxiety-in-a-professional-musician-undertaking-an-assessment-and-trial-therapy-of-intensive-short-term-dynamic-psychotherapy-istdp
#6
Dianna T Kenny, Stephen Arthey, Allan Abbass
INTRODUCTION: Kenny has proposed that severe music performance anxiety that is unresponsive to usual treatments such as cognitive-behaviour therapy may be one manifestation of unresolved attachment ruptures in early life. Intensive Short-Term Dynamic Psychotherapy specifically targets early relationship trauma. Accordingly, a trial of Intensive Short-Term Dynamic Psychotherapy with severely anxious musicians was implemented to assess whether resolution of attachment ruptures resulted in clinically significant relief from music performance anxiety...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27530166/race-religion-and-a-cat-in-the-clinical-hour
#7
Gretchen Heyer
Racial and religious identities are complex, often mired in dynamics of 'othering'. Such dynamics easily become a means of distancing the pain, fear and rage of intergenerational traumas, thus undermining ways race and religion can be powerful vehicles for the transference and countertransference. Drawing from a history of race in America as well as Jung's anxiety when meeting the stranger within himself, this paper focuses on 17 years of work between a black female patient and white female clinician (me)...
September 2016: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/27474498/involvement-of-high-mobility-group-box-1-in-the-development-and-maintenance-of-chemotherapy-induced-peripheral-neuropathy-in-rats
#8
Takeshi Nishida, Maho Tsubota, Yudai Kawaishi, Hiroki Yamanishi, Natsuki Kamitani, Fumiko Sekiguchi, Hiroyasu Ishikura, Keyue Liu, Masahiro Nishibori, Atsufumi Kawabata
Given that high mobility group box 1 (HMGB1), a nuclear protein, once released to the extracellular space, promotes nociception, we asked if inactivation of HMGB1 prevents or reverses chemotherapy-induced painful neuropathy in rats and also examined possible involvement of Toll-like receptor 4 (TLR4) and the receptor for advanced glycation endproduct (RAGE), known as targets for HMGB1. Painful neuropathy was produced by repeated i.p. administration of paclitaxel or vincristine in rats. Nociceptive threshold was determined by the paw pressure method and/or von Frey test in the hindpaw...
July 15, 2016: Toxicology
https://www.readbyqxmd.com/read/27343378/pattern-recognition-receptors-in-chronic-pain-mechanisms-and-therapeutic-implications
#9
REVIEW
Jungo Kato, Nilesh M Agalave, Camilla I Svensson
For the individual, it is vital to promptly detect and recognize a danger that threatens the integrity of the body. Pattern recognition receptors (PRRs) are several classes of protein families originally classified as receptors detecting exogenous pathogens. PRRs are also capable of recognizing molecules released from damaged tissues (damage-associated molecular pattern molecules; DAMPs) and thereby contribute to danger recognition. Importantly, it is now evident that PRRs, such as toll-like receptors (TLRs) and receptors for advanced glycation end products (RAGE), are not only expressed in peripheral immune cells but also present in neurons and glial cells in the nervous system...
October 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27335313/possible-involvement-of-the-hmgb1-rage-signaling-mechanism-in-the-induction-of-central-post-stroke-pain-induced-by-acute-global-cerebral-ischemia
#10
Shinichi Harada, Wataru Matsuura, Keyue Liu, Masahiro Nishibori, Shogo Tokuyama
Central post-stroke pain (CPSP) is one of the most under-recognized consequences of cerebral stroke, but the development of an effective treatment strategy is urgent. High-mobility group box 1 (HMGB1) and the receptor for advanced glycation end products (RAGE, one of the receptors of HMGB1) have recently been shown to be critical in the modulation of nociceptive transduction following peripheral neuropathy. The aim of this study was to determine the interactions between CPSP and HMGB1/RAGE signaling. Male ddY mice were subjected to 30min of bilateral carotid artery occlusion (BCAO)...
September 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27299140/diagnostic-value-of-clinical-findings-in-evaluation-of-thoracolumbar-blunt-traumas
#11
Ali Shahrami, Majid Shojaee, Seyed Mohammadreza Tabatabaee, Elaheh Mianehsaz
INTRODUCTION: Necessity of imaging for symptom-free conscious patients presented to emergency department (ED) following traumatic thoracolumbar spine injuries has been a matter of debate. The present study was aimed to evaluate the diagnostic value of clinical findings in prediction of traumatic thoracolumbar injuries compared tocomputed tomography (CT) scan. METHODS: The present diagnostic value study was carried out using non-random convenience sampling during the time between October 2013 and March 2014...
2016: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/27294160/the-emerging-role-of-hmgb1-in-neuropathic-pain-a-potential-therapeutic-target-for-neuroinflammation
#12
REVIEW
Wenbin Wan, Lan Cao, Ramin Khanabdali, Bill Kalionis, Xiantao Tai, Shijin Xia
Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of the disease, NPP still presents a major diagnostic and therapeutic challenge. High mobility group box 1 (HMGB1) mediates inflammatory and immune reactions in nervous system and emerging evidence reveals that HMGB1 plays an essential role in neuroinflammation through receptors such as Toll-like receptors (TLR), receptor for advanced glycation end products (RAGE), C-X-X motif chemokines receptor 4 (CXCR4), and N-methyl-D-aspartate (NMDA) receptor...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27141455/clinical-applications-of-low-intensity-pulsed-ultrasound-and-its-potential-role-in-urology
#13
REVIEW
Zhongcheng Xin, Guiting Lin, Hongen Lei, Tom F Lue, Yinglu Guo
Low-intensity pulsed ultrasound (LIPUS) is a form of ultrasound that delivered at a much lower intensity (<3 W/cm(2)) than traditional ultrasound energy and output in the mode of pulse wave, and it is typically used for therapeutic purpose in rehabilitation medicine. LIPUS has minimal thermal effects due to its low intensity and pulsed output mode, and its non-thermal effects which is normally claimed to induce therapeutic changes in tissues attract most researchers' attentions. LIPUS have been demonstrated to have a rage of biological effects on tissues, including promoting bone-fracture healing, accelerating soft-tissue regeneration, inhibiting inflammatory responses and so on...
April 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/26876723/the-cross-mammalian-neurophenomenology-of-primal-emotional-affects-from-animal-feelings-to-human-therapeutics
#14
REVIEW
Jaak Panksepp
The neural correlates of human emotions are easy to harvest. In contrast, the neural constitution of emotional feelings in humans has resisted systematic scientific analysis. This review summarizes how preclinical affective neuroscience initiatives are making progress in decoding the neural nature of such feelings in animal brains. This has been achieved by studying the rewarding and punishing effects of deep brain stimulation (DBS) of subcortical emotional networks (labeled SEEING, RAGE, FEAR, LUST, CARE, PANIC, and PLAY systems) that evoke distinct emotion action patterns, as well as rewarding and punishing effects in animals...
June 1, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/26814270/enhanced-rage-expression-in-the-dorsal-root-ganglion-may-contribute-to-neuropathic-pain-induced-by-spinal-nerve-ligation-in-rats
#15
Xiangnan Li, Haiqin Yang, Qing Ouyang, Fangting Liu, Jian Li, Zhenghua Xiang, Hongbin Yuan
OBJECTIVE:   There is some evidence implicating receptor for advanced glycation end products (RAGE) signaling in the pathogenesis of neuropathic pain (NP). The objective was to investigate whether RAGE signaling in the dorsal root ganglion (DRG) might contribute to NP following peripheral nerve injury. DESIGN:   Experimental study before and after spinal nerve ligation (SNL) surgery. SETTING:   Caged in a controlled environment. SUBJECTS:   Male Sprague-Dawley rats...
May 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26713421/protein-kinase-c-mediated-mu-opioid-receptor-phosphorylation-and-desensitization-in-rats-and-its-prevention-during-early-diabetes
#16
Shaaban A Mousa, Mohammed Shaqura, Jens Winkler, Baled I Khalefa, Mohammed A Al-Madol, Mehdi Shakibaei, Stefan Schulz, Michael Schäfer
Painful diabetic neuropathy is associated with impaired opioid analgesia; however, the precise mechanism in sensory neurons remains unclear. This study aimed to identify putative mechanisms involved in modified opioid responsiveness during early streptozotocin-induced diabetes in rats. In this study, we demonstrate that in diabetic animals, impaired peripheral opioid analgesia is associated with a reduction in functional mu-opioid receptor (MOR) G protein coupling. Mu-opioid receptor immunoreactive neurons colocalized with activated forms of protein kinase C (PKC) and with the receptor for advanced glycation end products (RAGE) during streptozotocin-induced diabetes...
April 2016: Pain
https://www.readbyqxmd.com/read/26434202/-measuring-the-functional-impairment-of-the-lumbar-spine
#17
Tamás Valasek, Péter Pál Varga, István Klemencsics, Zsolt Szövérfi, Árpád Bozsódi, Péter Endre Éltes, Áron Lazáry
BACKGROUND AND PURPOSE: The purpose of our study was to outline the Hungarian validation process of the Oswestry Disability Index, the Quebec Back Pain Disability Scale, the Roland-Morris Disability Questionnaire and the Core Outcome Measurement Index, as well as to draw up recommendations regarding their future applications. METHODS: The Hungarian versions were created after a cultural and linguistic adaptation. Next to the above-mentioned questionnaires, the questionnaire booklet used for validation also contained the WHOQoL-BREF general quality of life questionnaire and a pain measuring Visual Analog Scale...
March 30, 2015: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/26309701/total-elbow-joint-replacement-for-the-treatment-of-distal-humerus-fracture-of-type-c-in-eight-elderly-patients
#18
Wei Tian, Chao He, Jian Jia
OBJECTIVE: To analyze the outcomes of total elbow arthroplasty in the treatment of elderly type C distal humeral fractures and discuss the clinic efficacy. METHODS: 8 cases of elderly type C distal humeral fractures, Male was in one case, female in seven cases, and the average age was 66.5 years (60-81). All cases were closed fractures because of falling and none had associated injuries. According to AO classification, type C1 were in one cases, C2 in four cases and C3 in three cases...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26218952/tanshinone-iia-attenuates-chronic-pancreatitis-induced-pain-in-rats-via-downregulation-of-hmgb1-and-trl4-expression-in-the-spinal-cord
#19
Ye-song Wang, Yuan-yuan Li, Li-hua Wang, Ying Kang, Jie Zhang, Zi-quan Liu, Kun Wang, Alan David Kaye, Lei Chen
BACKGROUND: Chronic pancreatitis (CP) is a long-standing inflammation of the exocrine pancreas, which typically results in severe and constant abdominal pain. Previous studies on the mechanisms underlying CP-induced pain have primarily focused on the peripheral nociceptive system. A role for a central mechanism in the mediation or modulation of abdominal pain is largely unknown. Tanshinone IIA (TSN IIA), an active component of the traditional Chinese medicine Danshen, exhibits anti-inflammatory properties via downregulation of the expression of high-mobility group protein B1 (HMGB1), a late proinflammatory cytokine...
July 2015: Pain Physician
https://www.readbyqxmd.com/read/25744676/role-of-extracellular-damage-associated-molecular-pattern-molecules-damps-as-mediators-of-persistent-pain
#20
REVIEW
Jungo Kato, Camilla I Svensson
Damage-associated molecular pattern molecules (DAMPs) are endogenous molecules that are constitutively expressed and released upon tissue damage, resulting in activation of the immune system. In the absence of injury or infection, DAMPs play important intracellular roles. However, once released subsequent to cell damage or cell stress, DAMPs promote activation of innate immune cells and recruitment and activation of antigen-presenting cells engaged in host defense and tissue repair. This process involves pattern recognition receptors, such as the Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE)...
2015: Progress in Molecular Biology and Translational Science
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