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https://www.readbyqxmd.com/read/28716707/non-oxidizable-hmgb1-induces-cardiac-fibroblasts-migration-via-cxcr4-in-a-cxcl12-independent-manner-and-worsens-tissue-remodeling-after-myocardial-infarction
#1
Stefania Di Maggio, Giuseppina Milano, Francesco De Marchis, Alessandro D'Ambrosio, Matteo Bertolotti, Blanca Soler Palacios, Ileana Badi, Elena Sommariva, Giulio Pompilio, Maurizio C Capogrossi, Angela Raucci
Myocardial infarction (MI) is a major health burden worldwide. Extracellular High mobility group box 1 (HMGB1) regulates tissue healing after injuries. The reduced form of HMGB1 (fr-HMGB1) exerts chemotactic activity by binding CXCL12 through CXCR4, while the disulfide form, (ds-HMGB1), induces cytokines expression by TLR4. Here, we assessed the role of HMGB1 redox forms and the non-oxidizable mutant (3S) on human cardiac fibroblast (hcFbs) functions and cardiac remodeling after infarction. Among HMGB1 receptors, hcFbs express CXCR4...
July 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28715873/subcritical-water-hydrolyzed-fish-collagen-ameliorates-survival-of-endotoxemic-mice-by-inhibiting-hmgb1-release-in-a-ho-1-dependent-manner
#2
Min Young Ahn, Jung Seok Hwang, Sun Ah Ham, Jinwoo Hur, Yeonji Jo, SangYoon Lee, Mi-Jung Choi, Sung Gu Han, Han Geuk Seo
To investigate potential mechanisms underlying the bioactivity of hydrolyzed fish collagen, we examined the anti-inflammatory actions of subcritical water-hydrolyzed fish collagen (SWFC) in lipopolysaccharide (LPS)-triggered inflammation and endotoxemia. SWFC markedly inhibited LPS-stimulated release of high mobility group box 1 (HMGB1) in murine RAW264.7 macrophages, along with decreased cytosolic translocation of HMGB1. Both the protein and mRNA levels of heme oxygenase-1 (HO-1) were significantly upregulated in SWFC-treated RAW 264...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28713916/activation-of-the-hmgb1%C3%A2-tlr4%C3%A2-nf%C3%A2-%C3%AE%C2%BAb-pathway-may-occur-in-patients-with-atopic-eczema
#3
Yong Wang, Hui Weng, Jian Fei Song, Yun Hua Deng, Shuang Li, Hong Bo Liu
High mobility group protein B1 (HMGB1) has been reported to serve important roles in various pathological conditions. Toll‑like receptor 4 (TLR4), as one of the HMGB1 receptors, has been reported to be involved in the development of certain inflammatory diseases by activating nuclear factor NF‑κ‑B (NF‑κB). However, there are few studies investigating the effects of HMGB1, TLR4 and NF‑κB on human inflammatory dermatoses. In the present study, the distribution and characteristics of HMGB1, TLR4 and NF‑κB p65 expression in psoriasis and atopic eczema (AE) were investigated...
July 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713671/diagnostic-and-prognostic-biomarkers-for-malignant-mesothelioma-an-update
#4
REVIEW
Zhongjian Chen, Giovanni Gaudino, Harvey I Pass, Michele Carbone, Haining Yang
Malignant mesothelioma (MM) is an aggressive and lethal cancer, mostly related to inhalation of asbestos and erionite fibers. MM is associated with poor prognosis, because of its resistance to current therapies, even if higher survival occurs in patients diagnosed and treated when at stage I of the disease. However, these do not exceed 5% of the total number of cases, due to the inadequacy of the existing biomarkers for early and accurate diagnosis. Therefore, new effective biomarkers are needed for MM detection at earlier stages and to develop tailored therapies...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28712719/ages-rages-and-s-rage-friend-or-foe-for-cancer
#5
REVIEW
Saheem Ahmad, Hamda Khan, Zeba Siddiqui, Mohd Yasir Khan, Shahnawaz Rehman, Uzma Shahab, Tatyana Godovikova, Vladimir Silnikov, Moinuddin
Impaired awareness of glycation biology in cancer initiation and progression is one of the fundamental reasons for its meticulous investigation of the molecules involved in signalling pathway. Glycation of biological macromolecules results in the progression of advanced glycation end-products (AGEs) that proliferates the process of carcinogenesis by activation of transcription factors and release of cytokines. The receptor for advanced glycation end-products (RAGEs) with the binding of its different ligands like; AGEs, HMGB1 and S100 activate the signalling arrays...
July 13, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28711922/hmgb1-promotes-myeloid-derived-suppressor-cells-and-renal-cell-carcinoma-immune-escape
#6
Jinfeng Li, Jiajia Sun, Ruiming Rong, Long Li, Wenjun Shang, Dongkui Song, Guiwen Feng, Feifei Luo
Despite high immunogenicity and marked presence of immune cells in the RCC(renal cell carcinoma), immunotherapy fails to develop effective anti-tumor immune responses. This is due to the negative regulatory factors in the tumor microenvironment. As the main contributor of immunosuppression, myeloid-derived suppressor cells (MDSCs) inhibited anti-tumor immunity and promoted tumor progression. Meanwhile, it is confirmed that high mobility group box-1 protein (HMGB1) shows a high expression in many solid tumors and HMGB1 with high expression is involved in tumor immune escape...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28711488/immunomodulatory-intervention-with-gamma-interferon-in-mice-with-sepsis
#7
Yu Wang, Bing-Bing Kong, Wen-Ping Yang, Xin Zhao, Rong Zhang
AIMS: Sepsis-triggered immune paralysis including T-cell dysfunction increase susceptibility to infection. Gamma interferon (IFNg) exert beneficial effects in patients with sepsis. Herein, we speculated that IFNg may attenuate T-cell dysfunction induced by sepsis, although the mechanisms remain elusive. To test this hypothesis, we used a model based on cecal ligation and puncture (CLP) to induce sepsis in mice. MAIN METHODS: Male C57BL/6 mice were pretreated with recombinant human IFNg (0...
July 12, 2017: Life Sciences
https://www.readbyqxmd.com/read/28706912/diagnosis-and-prognosis-review-of-biomarkers-for-mesothelioma
#8
REVIEW
Huan H Sun, Allen Vaynblat, Harvey I Pass
Malignant pleural mesothelioma (MPM) is an aggressive disease arising in pleural cell lining and is associated with asbestos exposure. Today, there is a rising incidence of MPM reaching 3,000 annual cases nationally, primarily from the large population occupationally exposed to asbestos between 1940 and 1980. With a prolonged latency period, presenting clinically 10 to 40 years after exposure, MPM is often diagnosed in late stages and presents median survival time of less than 12 months. There is a serious need for improvement in prognostic and diagnostic tools for MPM...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706906/mesothelioma-recent-highlights
#9
REVIEW
Michele Carbone, Haining Yang
Recent discoveries have elucidated some of the mechanisms responsible for the development of mesothelioma. These discoveries are: (I) the critical role of chronic inflammation in promoting mesothelioma growth, driven by the release of high mobility group box protein-1 (HMGB1) following asbestos deposition in tissues and its potential role as a biomarker to identify asbestos exposed individuals and mesothelioma patients; (II) the discovery that inherited heterozygous germline mutations of the deubiquitylase BRCA-associated protein 1 (BAP1) cause a high incidence of mesothelioma in some families; and that (III) germline BAP1 mutations lower the threshold of asbestos required to cause mesothelioma in mice, evidence of gene X environment interaction...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28702094/disorders-of-nutritional-status-in-sepsis-facts-and-myths
#10
REVIEW
Katarzyna Kosałka, Ewelina Wachowska, Robert Słotwiński
The problem of diagnosing nutritional status disorders in septic patients remains unresolved. This is associated with the necessity of the introduction of newer and newer methods of assessing nutritional status, often requiring precise and expensive equipment as well as employment of professionals in this field in hospital wards, primarily including intensive care units (ICU). Methods that have been applied thus far for assessing nutritional status, also used in severely ill septic patients, have little impact on improving treatment results...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28701229/anti-high-mobility-group-box-1-hmgb1-antibody-attenuates-kidney-damage-following-experimental-crush-injury-and-the-possible-role-of-the-tumor-necrosis-factor-%C3%AE-and-c-jun-n-terminal-kinase-pathway
#11
Bin-Fei Zhang, Peng-Fei Wang, Yu-Xuan Cong, Jin-Lai Lei, Hu Wang, Hai Huang, Shuang Han, Yan Zhuang
BACKGROUND: Inflammation plays a crucial role in kidney damage after crush syndrome (CS). Several researchers report that high mobility group box-1 protein (HMGB1) may be the vital trigger in kidney damage, and tumor necrosis factor-α (TNF-α) and c-Jun N-terminal kinase (JNK) are involve in this pathophysiological process, but their biological roles are unclear. This study aimed to explore the relationship between HMGB1, JNK, and TNF-α in kidney damage. METHODS: The crush injury model was established using weight compression...
July 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28699371/minocycline-attenuates-high-mobility-group-box-1-translocation-microglial-activation-and-thalamic-neurodegeneration-after-traumatic-brain-injury-in-postnatal-day-17-rats
#12
Dennis William Simon, Rajesh K Aneja, Henry Alexander, Michael J Bell, Hulya Bayir, Patrick M Kochanek, Robert S B Clark
In response to cell injury the danger signal high mobility group box-1 (HMGB) is released, activating macrophages by binding pattern recognition receptors. We investigated the role of the anti-inflammatory drug minocycline in attenuating HMGB1 translocation, microglial activation, and neuronal injury in a rat model of pediatric traumatic brain injury (TBI). Postnatal day 17 Sprague-Dawley rats were subjected to moderate-severe controlled cortical impact (CCI). Animals were randomized to treatment with minocycline (90 mg/kg, i...
July 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28697972/neuroprotection-of-edaravone-on-the-hippocampus-of-kainate-induced-epilepsy-rats-through-nrf2-ho-1-pathway
#13
Zhiguang Liu, Chengzhi Yang, Xinyan Meng, Zaili Li, Cunling Lv, Peiwei Cao
Epilepsy is a severe and chronic neurological disease. Edaravone is an effective free radical scavenger and has been reported to prevent neuronal loss induced by Kainate (KA). However, the molecular mechanisms by which edaravone inhibits KA-induced neuron injury remain elusive. Seventy adult male Wistar rats were randomly divided into 7 groups. For KA treatment, Kainate (4 μg/kg) were administrated in the right hippocampus CA3 region with sereotactic technique. And for edaravone treatment, the rats were intraperitoneal injection with edaravone (10 mg kg (- 1) d (- 1))...
July 8, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28695466/oxidative-stress-dependent-contribution-of-hmgb1-to-the-interplay-between-apoptosis-and-autophagy-in-diabetic-rat-liver
#14
Anja Petrović, Desanka Bogojević, Aleksandra Korać, Igor Golić, Sofija Jovanović-Stojanov, Vesna Martinović, Svetlana Ivanović-Matić, Jelena Stevanović, Goran Poznanović, Ilijana Grigorov
The progression of oxidative stress, resulting cell damage, and cell death underlies the etiology of liver damage/dysfunction as a complication of diabetes. High-mobility group box 1 (HMGB1) protein, a chromatin-binding nuclear protein and damage-associated molecular pattern molecule, is integral to oxidative stress and signaling pathways regulating cell death and cell survival. We previously found that in streptozotocin (STZ)-induced diabetic rats, reduction of oxidative stress after melatonin administration lowered necrotic cell death and increased expression of HMGB1 and hepatocellular damage...
July 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28694564/hmgb1-and-extracellular-histones-significantly-contribute-to-systemic-inflammation-and-multiple-organ-failure-in-acute-liver-failure
#15
REVIEW
Runkuan Yang, Xiaoping Zou, Jyrki Tenhunen, Tor Inge Tønnessen
Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes. ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity. ALF has a high mortality that is associated with multiple organ failure (MOF) and sepsis; however, the underlying mechanisms are still not clear. Emerging evidence shows that ALF patients/animals have high concentrations of circulating HMGB1, which can contribute to multiple organ injuries and mediate gut bacterial translocation (BT)...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28693241/the-novel-immunomodulator-immunepotent-crp-combined-with-chemotherapy-agent-increased-the-rate-of-immunogenic-cell-death-and-prevented-melanoma-growth
#16
Maria Del Carmen Rodríguez-Salazar, Moises Armides Franco-Molina, Edgar Mendoza-Gamboa, Ana Carolina Martínez-Torres, Pablo Zapata-Benavides, Jose Sullivan López-González, Erika Evangelina Coronado-Cerda, Juan Manuel Alcocer-González, Reyes Silvestre Tamez-Guerra, Cristina Rodríguez-Padilla
Immunogenic cell death is a cell death modality that stimulates the immune system to combat cancer cells. IMMUNEPOTENT CRP (ICRP) is a mixture of substances of low molecular weight obtained from bovine spleens that exhibits in vitro cytotoxic activity on different tumor cell lines and modulates the immune response in vivo. The aim of the present study was to determine whether the cytotoxic effect of ICRP and its combination with oxaliplatin (OXP) on murine melanoma B16F10 cells was due to immunogenic cell death...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693148/expression-levels-and-clinical-significance-of-hepsin-and-hmgb1-proteins-in-cervical-carcinoma
#17
Hui Cheng, Weiqi Wang, Yanling Zhang, Bei Zhang, Jie Cheng, Peng Teng, Xin Tang
This study assessed the hypothesis that the protein levels of high mobility group box 1 (HMGB1) and hepsin can be used as markers for diagnosis and prognosis in cervical carcinoma. Seventy patients with cervical cancer who were hospitalized in Xuzhou Central Hospital from May 2008 to June 2010 and underwent surgical treatment were selected for the observation group. At the same time, 20 patients with cervical benign lesions who underwent tumor stripping or accessory resection were selected for the control group...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692534/blood-neuron-derived-exosomes-as-biomarkers-of-cognitive-impairment-in-hiv
#18
Bing Sun, Pranjali Dalvi, Linda Abadjian, Norina Tang, Lynn Pulliam
OBJECTIVE: To investigate proteins associated with neuronal damage in plasma neuron-derived exosomes (NDE) of HIV-infected subjects as a liquid biomarker for cognitive impairment. METHODS: Plasma NDE were isolated using precipitation and immunoadsorption with antibody to a cell surface specific neuronal marker. Total exosomes and NDE were enumerated, characterized and proteins extracted and targets quantified by ELISA. RESULTS: Plasma NDE from 23 HIV seropositive individuals of which 11 had mild cognitive impairment, and 12 HIV seronegative controls of which 3 had cognitive impairment were isolated...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28690198/punicalagin-a-ptp1b-inhibitor-induces-m2c-phenotype-polarization-via-up-regulation-of-ho-1-in-murine-macrophages
#19
Xiaolong Xu, Yuhong Guo, Jingxia Zhao, Shasha He, Yan Wang, Yan Lin, Ning Wang, Qingquan Liu
Current data have shown that punicalagin (PUN), an ellagitannin isolated from pomegranate, possesses anti-inflammatory and anti-oxidant properties; however, its direct targets have not yet been reported. This is the first report that PTP1B serves as a direct target of PUN, with IC50 value of 1.04μM. Results from NPOI further showed that the Kon and Koff of PUN-PTP1B complex were 3.38e2M(-1)s(-1) and 4.13e-3s(-1), respectively. The active site Arg24 of PTP1B was identified as a key binding site of PUN by computation simulation and point mutation...
July 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28685526/glycyrrhetinic-acid-suppressed-hmgb1-release-by-up-regulation-of-sirt6-in-nasal-inflammation
#20
D Chen, L M Bellussi, S Cocca, J Wang, G C Passali, X Hao, L Chen, D Passali
To extend our understanding of previous studies on the pathogenesis and mechanism of high mobility group box 1 (HMGB1) in chronic rhinosinusitis with nasal polyps (CRSwNP), here we show that Sirtuin 6 (Sirt6), one of the Sirtuin family members which are widely studied in aging, DNA repair, metabolism, inflammation and cancer, was expressed in normal nasal mucosa using immunohistochemical staining and Western blot assay. Sirt6 expression levels were decreased in CRSwNP tissue. Sirt6 expression levels were modulated by small interfering RNA transfection in human nasal epithelial cells (HNE)...
April 2017: Journal of Biological Regulators and Homeostatic Agents
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