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https://www.readbyqxmd.com/read/29777754/hmgb1-neutralization-attenuates-hippocampal-neuronal-death-and-cognitive-impairment-in-rats-with-chronic-cerebral-hypoperfusion-via-suppressing-inflammatory-responses-and-oxidative-stress
#1
Yue Hei, Rong Chen, Xicai Yi, Qianfa Long, Dakuan Gao, Weiping Liu
High mobility group box-1 (HMGB1) acts as a proinflammatory molecule once released into the extracellular space and inhibition of HMGB1 signaling has been reported be neuroprotective in neurodegenerative diseases. Besides, chronic cerebral hypoperfusion (CCH) causes cognitive impairment in neurodegenerative diseases. Here we tested the protective role of HMGB1 inhibition using anti-HMGB1 neutralizing antibody (Ab) against CCH in rats after bilateral common carotid artery occlusion (2VO). 169 male Sprague-Dawley rats underwent 2VO or sham operation...
May 16, 2018: Neuroscience
https://www.readbyqxmd.com/read/29774570/high-mobility-group-box-1-drives-fibrosis-progression-signaling-via-the-receptor-for-advanced-glycation-end-products-in-mice
#2
Xiaodong Ge, Elena Arriazu, Fernando Magdaleno, Daniel J Antoine, Rouchelle Dela Cruz, Neil Theise, Natalia Nieto
BACKGROUND & RATIONALE: High-mobility group box-1 (HMGB1) is a damage-associated molecular pattern (DAMP) increased in response to liver injury. Since HMGB1 is a ligand for the receptor for advanced glycation end-products (RAGE), we hypothesized that induction of HMGB1 could participate in the pathogenesis of liver fibrosis via RAGE cell-specific signaling mechanisms. RESULTS: liver HMGB1 protein expression correlated with fibrosis stage in patients with chronic Hepatitis C virus (HCV) infection, primary biliary cirrhosis (PBC) and alcoholic steatohepatitis (ASH)...
May 18, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29773200/lithium-chloride-attenuates-mitomycin-c-induced-necrotic-cell-death-in-mda-mb-231-breast-cancer-cells-via-hmgb1-and-bax-signaling
#3
Mahdieh Razmi, Azra Rabbani-Chadegani, Fatemeh Hashemi-Niasari, Parinaz Ghadam
The clinical use of potent anticancer drug mitomycin C (MMC) has limited due to side effects and resistance of cancer cells. The aim of this study was to investigate whether lithium chloride (LiCl), as a mood stabilizer, can affect the sensitivity of MDA-MB-231 breast cancer cells to mitomycin C. The cells were exposed to various concentrations of mitomycin C alone and combined with LiCl and the viability determined by trypan blue and MTT assays. Proteins were analyzed by western blot and mRNA expression of HMGB1 MMP9 and Bcl-2 were analyzed by RT-PCR...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29768967/interleukin-1-receptor-1-deletion-in-focal-and-diffuse-experimental-traumatic-brain-injury-in-mice
#4
Joon Yong Chung, Nicolas Krapp, Limin Wu, Sevda Lule, Lauren McAllister, William Edmiston Iii, Samantha Martin, Emily Levy, Tanya Songtachalert, John Sherwood, Erin Buckley, Bharat Sanders, Saef Izzy, Suzanne Hickman, Shuzhen Guo, Josephine Lok, Joseph El Khoury, Eng Lo, David Kaplan, Michael Whalen
Important differences in the biology of focal and diffuse traumatic brain injury (TBI) subtypes may result in unique pathophysiological responses to shared molecular mechanisms. Interleukin-1 (IL-1) signaling has been tested as a potential therapeutic target in preclinical models of cerebral contusion and diffuse TBI, and in a phase II clinical trial, but no published studies have examined IL-1 signaling in an impact/acceleration closed head injury (CHI) model. We hypothesized that genetic deletion of IL-1 receptor-1 (IL-1R1 KO) would be beneficial in focal (contusion) and CHI in mice...
May 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29763644/immunomodulatory-effect-of-celecoxib-on-hmgb1-tlr4-pathway-in-a-recurrent-seizures-model-in-immature-rats
#5
Mariana Morales-Sosa, Sandra Orozco-Suárez, AngélicaVega-García, Sara Caballero-Chacón, Iris A Feria-Romero
Epileptic seizures constitute an important problem in pediatric neurology during the developmental period. The frequency and nosological significance of seizures, as well as their association with epileptogenesis, may be related to underlying mechanisms such as neuroinflammation. Those mechanisms of response activate inflammatory molecules induced in the neurons, activated glial cells and endothelial cells via the key HMGB1/TLR4 pathway. In this study, the drug celecoxib (CCX) was used as a blocker of the cyclooxygenase 2 (COX-2) and HMGB1/TLR-4 pathways...
May 12, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29763588/glycyrrhizin-ameliorates-inflammatory-pain-by-inhibiting-microglial-activation-mediated-inflammatory-response-via-blockage-of-the-hmgb1-tlr4-nf-kb-pathway
#6
Xiaojuan Sun, Hongyou Zeng, Qingsong Wang, Qingwen Yu, Jianxiong Wu, You Feng, Peng Deng, Hongxing Zhang
Chronic inflammatory pain is a severe clinical problem that greatly affects patients' quality of life and causes huge economic burden. Microglia-mediated neuroinflammation exerts critical roles in the pathogenic progression of inflammatory pain. Recent evidence corroborates the anti-inflammatory and neuroprotective efficacy of glycyrrhizin; however, its function in inflammatory pain remains poorly elucidated. In the present study, glycyrrhizin suppressed LPS-induced activation of microglial cell BV2 by inhibiting NO production and expression of microglial marker IBA-1...
May 12, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29762840/the-effect-of-mir-146a-gene-silencing-on-drug-resistance-and-expression-of-protein-of-p-gp-and-mrp1-in-epilepsy
#7
H-L Zhang, Y-H Lin, Y Qu, Q Chen
OBJECTIVE: To investigate the effect of miR-146a gene silencing on brain tissue and related drug-resistance proteins in rats and explore its resistance mechanism. MATERIALS AND METHODS: A rat model of chronic refractory epilepsy was established. The rats were divided into four groups: Normal group, Model group, Negative control group and AntagomiR-146a group. Hematoxylin and eosin (HE) stain was used to detect brain histopathological changes. We examined the expression of mRNA of miR-146a, multidrug resistance (MDR1) and multidrug-resistant associated protein (MRP1) by RT-PCR...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29762033/isolation-synthesis-and-antisepsis-effects-of-a-c-methylcoumarinochromone-isolated-from-abronia-nana-cell-culture
#8
Wonhwa Lee, Doohyun Lee, Yuri Lee, Taeho Lee, Kyung-Sik Song, Eun-Ju Yang, Jong-Sup Bae
Only a few isoflavones have been isolated from plants of the genus Abronia. The biological properties of compounds isolated from Abronia species have not been well established, and their antisepsis effects have not been reported yet. In the present study, a new C-methylcoumarinochromone, was isolated from Abronia nana suspension cultures. Its structure was deduced as 9,11-dihydroxy-10-methylcoumarinochromone (boeravinone Y, 1) by spectroscopic data analysis and verified by chemical synthesis. The potential inhibitory effects of 1 against high mobility group box 1 (HMGB1)-mediated septic responses were investigated...
May 15, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29755641/ischemic-preconditioning-attenuates-acute-lung-injury-after-partial-liver-transplantation
#9
Qinlong Liu, Hasibur Rehman, Yasodha Krishnasamy, John J Lemasters, Zhi Zhong
Pulmonary complications frequently occur after liver transplantation and are often life-threatening. Thus, we investigated whether hepatic ischemic preconditioning (IP) attenuates acute lung injury (ALI) after small-for-size liver transplantation. Rat livers were explanted after 9-min ischemia plus 5-min reperfusion, reduced to 50% of original size ex vivo , and implanted into recipients with approximately twice the donor body weight, resulting in quarter-size liver grafts (QSG). After QSG transplantation, hepatic Toll-like receptor 4 (TLR4) and tumor necrosis factor-α (TNFα ) expression increased markedly and high mobility group box-1 (HMGB1), an endogenous damage-associated molecular pattern molecule (DAMP), was released from QSG into the blood...
2018: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29753015/lncrna-zeb2-as1-promotes-pancreatic-cancer-cell-growth-and-invasion-through-regulating-the-mir-204-hmgb1-axis
#10
Hai Gao, Nana Gong, Zebin Ma, Xiaobo Miao, Jinchun Chen, Yan Cao, Gong Zhang
Recently, lncRNA ZEB2-AS1 was identified as a lncRNA that promoted cancer progression. However, the biological function and the underlying mechanism of ZEB2-AS1 in pancreatic cancer had not been reported. In the current study, we revealed that the expression level of ZEB2-AS1 was elevated in pancreatic cancer cell lines and tissues. ZEB2-AS1 inhibition decreased cell growth and invasion in pancreatic cancer. Mechanismly, ZEB2-AS1 exerted as a ceRNA and negatively regulated miR-204 expression. In addition, HMGB1 was identified as a down-stream target of miR-204...
May 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29752949/the-change-of-nuclear-lc3-distribution-in-acute-myeloid-leukemia-cells
#11
Guo Wenjian, Jin Jingrui, Pan Jiajia, Yao Rongxing, Li Xia, Huang Xin, Ma Zhixing, Huang Sujuan, Yan Xiao, Jin Jie, Dong Aishu
Making sure the change of nuclear LC3 distribution in the autophagy of acute myeloid leukemia (AML) cell and finding out the regulation mechanism may lead to a breakthrough for killing AML cells. Western blots were performed to assess the expression of autophagy proteins. Changes in the LC3 distribution were monitored by immunofluorescence assays together with western blots, and the expression levels of Sirt1, DOR, Beclin1, HMGB1, and AMPK mRNA were detected via fluorescent quantitative PCR. The effects of Sirt1 and DOR on cell proliferation and survival were analyzed by MTT, flow cytometry, and western blotting assays...
May 9, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29751935/down-regulation-of-mir-218-5p-promotes-apoptosis-of-human-umbilical-vein-endothelial-cells-through-regulating-high-mobility-group-box-1-in-henoch-schonlein-purpura
#12
Shao-Fei Yu, Wan-Yu Feng, Shao-Qing Chai, Xiao-Bo Meng, Zhong-Xia Dou, Hua Zhu
BACKGROUND: Apoptosis of human umbilical vein endothelial cells (HUVECs) plays an important role in the progression of Henoch-Schonlein purpura (HSP). In the present study, we explored the function of miR-218-5p in HUVEC apoptosis and HSP development. MATERIALS AND METHODS: HSP rat model was established and peripheral blood mononuclear cells (PBMC) were isolated. The expression of miR-218-5p and high-mobility group box-1 (HMGB1) protein in HUVECs was determined by quantitative real-time polymerase chain reaction and western blot, respectively...
April 5, 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29745087/high-mobility-group-box-1-hmgb1-expression-in-gastric-adenocarcinomas
#13
Dinc Suren, Ahmet Arda Gokay, Alper Sayiner
PURPOSE: High mobility group box 1 (HMGB1), the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. The purpose of this study was to investigate the expression of HMGB-1 in gastric adenocarcinoma (GC) and to evaluate its diagnostic and prognostic value. METHODS: This study included 85 cases histopathologically diagnosed with GC...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29743526/pretreatment-of-huaiqihuang-extractum-protects-against-cisplatin-induced-nephrotoxicity
#14
Yujiao Guo, Meng Wang, Jingyi Mou, Zhi Zhao, Juan Yang, Fengming Zhu, Guangchang Pei, Han Zhu, Yuxi Wang, Gang Xu, Rui Zeng, Ying Yao
Cisplatin is a commonly used chemotherapeutic agent in the treatment of different types of malignant tumors, but nephrotoxicity limits its usage. Therefore, in this study, we aimed to determine the possible protective effect of Huaiqihuang (HQH) extractum, a kind of Chinese herbal complex that consists of Trametes robiniophila Murr., Lycium barbarum and Polygonatum sibiricum, against nephrotoxicity induced by cisplatin in mice. We found that pretreatment with HQH significantly attenuated the cisplatin-induced increase in blood urea nitrogen (BUN), interstitial congestion, acute renal tubular injury and tubular cell apoptosis and necroptosis...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742510/hmgb1-a-box-reverses-brain-edema-and-deterioration-of-neurological-function-in-a-traumatic-brain-injury-mouse-model
#15
Lijun Yang, Feng Wang, Liang Yang, Yunchao Yuan, Yan Chen, Gengshen Zhang, Zhenzeng Fan
BACKGROUND/AIMS: Traumatic brain injury (TBI) is a complex neurological injury in young adults lacking effective treatment. Emerging evidences suggest that inflammation contributes to the secondary brain injury following TBI, including breakdown of the blood brain barrier (BBB), subsequent edema and neurological deterioration. High mobility group box-1 (HMGB1) has been identified as a key cytokine in the inflammation reaction following TBI. Here, we investigated the therapeutic efficacy of HMGB1 A-box fragment, an antagonist competing with full-length HMGB1 for receptor binding, against TBI...
May 8, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29741224/angiotensin-ii-enhances-the-acetylation-and-release-of-hmgb1-in-raw264-7-macrophage
#16
Shanshan Zhou, Hongxiang Lu, Rong Chen, Yu Tian, YuanYuan Jiang, Shiqing Zhang, Daobing Ni, Zhaoliang Su, Xiaoyi Shao
The high-mobility group box-1 (HMGB1), as a highly conserved ubiquitous DNA-binding protein, has been widely studied in various diseases, including inflammation and tumor; however, fewer studies were focused on the mechanisms controlling HMGB1 release compared with the function of HMGB1. Previous studies have proven that ANG II can act as a pro-inflammatory cytokine, both of HMGB1 and ANG II were significantly upregulated in autoimmune diseases, however, the exact role of ANG II in regulating HMGB1 release have not been shown...
May 9, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29737584/metformin-increases-the-cytotoxicity-of-oxaliplatin-in-human-dld-1-colorectal-cancer-cells-through-down-regulating-hmgb1-expression
#17
Wen-Shih Huang, Chien-Tsong Lin, Cheng-Nan Chen, Shun-Fu Chang, Hsin-I Chang, Ko-Chao Lee
Colorectal cancer (CRC) is the fourth most common cause of cancer death worldwide. Chemotherapy has been the major strategy for treating patients with advanced CRC. Oxaliplatin (OXA) is used as both an adjuvant and neoadjuvant anticancer agent available to treat advanced CRC. High-mobility group box 1 protein (HMGB1) is a critical regulator of cell death and survival. HMGB1 overexpression has been shown to be resistant to cytotoxic agents. In addition, Metformin, a widely used drug for diabetes, has emerged as a potential anticancer agent...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29736733/paeonol-reduces-the-nucleocytoplasmic-transportation-of-hmgb1-by-upregulating-hdac3-in-lps-induced-raw264-7-cells
#18
Qin Xu, Xia Liu, Liyan Mei, Quan Wen, Jing Chen, Jifei Miao, Hang Lei, Huina Huang, Dongfeng Chen, Shaohui Du, Aijun Liu, Saixia Zhang, Jianhong Zhou, Rudong Deng, Yiwei Li, Chun Li, Hui Li
Extracellular high mobility group box 1 (HMGB1) is a lethal pro-inflammatory mediator in endotoxin shock. Hyperacetylation of HMGB1, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), changes its subcellular localization and secretion to the extracellular matrix. Paeonol (2'-hydroxy-4'-methoxyacetophenone), one of the main active components of Paeonia suffruticosa, exerts anti-inflammatory effects. Our previous study demonstrated that Paeonol inhibited the relocation and secretion of HMGB1 in lipopolysaccharide (LPS)-activated RAW264...
May 7, 2018: Inflammation
https://www.readbyqxmd.com/read/29736208/schizandrin-b-protects-lps-induced-sepsis-via-tlr4-nf-%C3%AE%C2%BAb-myd88-signaling-pathway
#19
Jianjun Xu, Caijiao Lu, Zhengjun Liu, Peng Zhang, Hailei Guo, Tingting Wang
Schizandrin B ( Sch B ) is the main component isolated from Schizandra fruit ( Schisandra chinensis ). While Sch B is established as having antioxidant, anti-proliferation and anti-inflammatory properties, but its activity in sepsis remains unclear. In the present study, we investigated the anti-inflammatory effects of Sch B in sepsis. Our experimental results demonstrated that Sch B inhibited production of IL-1β, TNF-α, IL-6 and HMGB1 by LPS-activated RAW264.7 cells. Moreover, Sch B suppressed expression of iNOS, reduced production of PGE2, blocked expression of MyD88 and TLR4, suppressed the activity of NF-κB and decreased phosphorylation of MAPKs in LPS-activated RAW264...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29730397/high-mobility-group-box-1-protein-hmgb1-gene-polymorphisms-and-cancer-susceptibility-a-comprehensive-meta-analysis
#20
REVIEW
Taruna Kumari, Bhupender Kumar
AIM: The role of HMGB1 polymorphisms in cancer predisposition remains unclear. This meta-analysis was performed assess four HMGB1 polymorphisms (rs1045411, rs2249825, rs1360485 and rs1412125) in cancer risk. METHODS: We searched published studies till January 2018 from EMBASE, PubMed, Google scholar, and Cochrane library. Thereafter, the statistical software "R" was used to calculate Pooled Odds Ratios (OR), and 95% confidence intervals (CI) for assessment of association between different HMGB1 polymorphisms and cancer risk...
May 3, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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