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https://www.readbyqxmd.com/read/29133525/optineurin-promotes-autophagosome-formation-by-recruiting-the-autophagy-related-atg12-5-16l1-complex-to-phagophores-containing-the-wipi2-protein
#1
Megha Bansal, Shivranjani C Moharir, S Purnima Sailasree, Kapil Sirohi, Cherukuri Sudhakar, D Partha Sarathi, B Jyothi Lakshmi, Mario Buono, Satish Kumar, Ghanshyam Swarup
Autophagy is a quality-control mechanism that helps to maintain cellular homeostasis by removing damaged proteins and organelles through lysosomal degradation. During autophagy, signaling events lead to the formation of a cup-shaped structure called the phagophore that matures into the autophagosome. Recruitment of the autophagy-associated Atg12-5-16L1 complex to wipi2-positive phagophores is crucial for producing LC3-II, which is required for autophagosome formation. Here, we explored the role of the autophagy receptor optineurin (Optn) in autophagosome formation...
November 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29132240/can-surgical-guidelines-minimize-complications-after-ma%C3%A3-a%C3%A2-trapeziometacarpal-joint-arthroplasty-with-unconstrained-cups
#2
Pieter Caekebeke, Joris Duerinckx
The most important complications of trapeziometacarpal arthroplasty are dislocation and component loosening. Incorrect cup position is often a contributing factor. Intra-operative guidelines to optimize cup orientation have recently been described. We evaluated the functional and radiological outcome of 50 Maïa® trapeziometacarpal prostheses that were implanted according to these guidelines. The minimum follow-up was 56 months. No constrained cups were used. Functional outcome was good to excellent. No spontaneous dislocations occurred...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29129617/computed-tomographic-evaluation-of-bone-stock-in-patients-with-crowe-type-iii-developmental-dysplasia-of-the-hip-implications-for-guiding-acetabular-component-placement-using-the-high-hip-center-technique
#3
Bo Liu, Yu-Hang Gao, Lu Ding, Shu-Qiang Li, Jian-Guo Liu, Xin Qi
BACKGROUND: We evaluated acetabular cup coverage (CC) and rim contact (RC) to evaluate the bone stock above the acetabulum for guiding acetabular component placement using the high hip center technique in patients with Crowe type III developmental dysplasia of the hip. METHODS: Using hip computed tomography and image processing software, pelvises were reconstructed digitally in 20 hips with Crowe type III developmental dysplasia of the hip. Mimicked cup was placed with anteversion angles of 0° (group I), 5° (group II), and 10° (group III) respectively...
October 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29125217/an-evaluation-of-the-impact-of-fifa-world-cup-on-soccer-emergency-department-injuries-among-montreal-adolescents
#4
Glenn Keays, Debbie Friedman, Marianne Beaudin, Isabelle Gagnon
AIM: The 'trickle-down effect', or how major sports events have a positive impact on sports participation, has been the subject of many studies, but none produced conclusive results. We took a different approach and rather than look at sports participation, we used injuries as a proxy and see if injuries increased, or remained the same, after the International Federation of Association Football World Cup. METHODS: Using a retrospective cohort design, we looked at the injuries suffered by males and females (13-16 years old) while playing team sports in Montreal, that occurred in May to July, from 1999 to 2014...
November 10, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29122687/is-anatomic-acetabular-orientation-related-to-pelvic-morphology-ct-analysis-of-150-healthy-pelvises
#5
P Sautet, H Giorgi, P Chabrand, P Tropiano, J-N Argenson, S Parratte, B Blondel
BACKGROUND: Links between sagittal spinal alignment and acetabular orientation attract considerable research attention with the goal of optimising prosthetic cup position. However, whether pelvic incidence (PI) is related to anatomic acetabular orientation remains unknown. We therefore conducted a radiological study with the following objectives: to look for correlations between PI and anatomic acetabular parameters; to describe the sacro-pubic angle (SPA), defined by fixed bony pelvic landmarks, and its relations with acetabular inclination; and to determine whether anatomical parameters (PI and SPA) correlate with demographic characteristics...
November 6, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29103737/synchronous-bilateral-tonsillar-carcinomas-patient-characteristics-and-human-papillomavirus-genotypes
#6
Camelia Nami Saber, Christian Grønhøj, David Hebbelstrup Jensen, Cecilie Nørregaard, Amanda Carlander, Emilie Garnæs, Katalin Kiss, Lena Specht, Christian von Buchwald
INTRODUCTION: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing, but data on the incidence of synchronous, bilateral tonsillar squamous cell carcinomas (BiTSCCs) is sparse. In this study, we report the incidence and tumour characteristics of BiTSCCs in a population-based, consecutive cohort of OPSCCs. METHODS: We identified all patients diagnosed with tonsillar squamous cell carcinoma (TSCC) in eastern Denmark during a 15-year period to detect the incidence of synchronous BiTSCCs...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29098919/current-methods-of-preventing-aseptic-loosening-and-improving-osseointegration-of-titanium-implants-in-cementless-total-hip-arthroplasty-a-review
#7
Dragos Apostu, Ondine Lucaciu, Cristian Berce, Dan Lucaciu, Dan Cosma
Hip osteoarthritis is the most common joint disorder, and is represented by a degenerative process, resulting in pain and functional impairment. If conservative treatment for hip osteoarthritis fails, the only remaining option is hip arthroplasty. Despite good survival of implants, loosening of components is the most common complication. This leads to revision surgeries, which are technically demanding, expensive, and result in a low satisfaction rate. Uncemented hip replacements require proper osseointegration for increased survival...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29072829/actual-daily-intakes-of-tea-catechins-and-thier-estimation-according-to-four-season-3-day-weighed-dietary-records-and-a-short-food-frequency-questionnaire-among-japanese-men-and-women
#8
Kaori Endoh, Yuji Matsui, Masao Takeshita, Mitsuhiro Katashima, Koichi Yasunaga, Kiyonori Kuriki
Background: Tea catechins are considered to be important preventive factors of cancer on several organs; however, the relationships of the actual daily intakes (ADIs) on the preventive effects have not been adequately addressed. We measured the ADIs of tea catechins as annual averages derived from every their ingested cups recorded by each subject, and the estimation models were established considering tea origin. Methods: Fifty-nine Japanese men and women completed four season 3 day weighed dietary records (WDRs) and a food frequency questionnaire (FFQ), and samples of green, oolong and black teas, ingested during a total 12 days were collected for the analysis...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29071707/the-influence-of-grasping-habits-and-object-orientation-on-motor-planning-in-children-and-adults
#9
Bianca Jovanovic, Gudrun Schwarzer
We investigated the influence of habitual grasp strategies and object orientation on motor planning in 3-year-olds and 4- to 5-year-old children and adults. Participants were required to rotate different vertically oriented objects around 180°. Usually, adults perform this task by grasping objects with an awkward grip (thumb and index finger pointing downward) at the beginning of the movement, in order to finish it with a comfortable hand position. This pattern corresponds to the well-known end-state comfort effect (ESC) in grasp planning...
October 25, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29064816/-coffee-drinking-and-health-the-current-state-of-knowledge-whether-the-end-of-the-doubts-of-patients-is-already-coming
#10
Regina Wierzejska
The impact of drinking coffee on health is still relevant in medicine. Patients, as well as some doctors noticed coffee as the product which can cause or increase a risk a lot of health complaints. However contemporary scientific researches are more optimistic and revealed that coffee doesn't have such negative impact on health, and what's more can has beneficial action. In spite of some differences in findings many of them demonstrated a lack of relationship between coffee and blood pressure, cancers, and in case of type 2 diabetes and neurodegenerative diseases even a protective action is possible...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29048696/the-direct-anterior-minimal-invasive-approach-in-total-hip-replacement-a-prospective-departmental-study-on-the-learning-curve
#11
Ole-Christian L Brun, Lukas Månsson, Lars Nordsletten
INTRODUCTION: Introduction of new surgical techniques is normal, but seldom monitored in real time. The purpose of this study was to monitor the learning curve when introducing a new surgical technique to a department. We did a prospective evaluation of the learning curve when introducing the minimally invasive direct anterior approach in total hip arthroplasty. We wish to investigate whether there is a learning curve for the direct anterior minimal invasive approach in total hip replacement and what are the early complications to this approach...
October 16, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29033154/the-use-of-porous-tantalum-augments-for-the-reconstruction-of-acetabular-defect-in-primary-total-hip-arthroplasty
#12
Ting-Xian Ling, Jin-Long Li, Kai Zhou, Qiang Xiao, Fu-Xing Pei, Zong-Ke Zhou
BACKGROUND: Given the lack of studies of acetabular defect reconstruction in primary total hip arthroplasty (THA) using tantalum augments, this study aims to evaluate clinical and radiographic results for treatment with tantalum augments to reconstruct acetabular defects in primary THA. METHODS: We retrospectively reviewed 19 patients (19 hips) with acetabular defects who underwent primary THA using tantalum augments, with a minimum follow-up of 2 years. Clinical, radiographic, and surgical data were retrospectively evaluated...
September 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29027688/preoperative-ultrasonographic-assessment-of-the-anterior-pelvic-plane-for-personalized-total-hip-replacement
#13
Andrzej Kochman, Adrian Goral, Josef Kozak, Wojciech Marek, Monika Morawska-Kochman, Marek Synder
OBJECTIVES: Correct positioning of the acetabular component is a key factor in minimizing the risk of dislocation after total hip replacement (THR) surgery. A "safe" orientation of the cup is usually defined by 2 angles measured between its geometric axis and the anterior pelvic plane. However, in the current state-of-the-art approach to THR surgery, the intraoperative orientation of the anterior pelvic plane cannot be measured. Even less is known about the functional orientation of the pelvis, which determines the postoperative orientation of the cup during the patient's everyday activities...
October 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29025033/heavier-smoking-increases-coffee-consumption-findings-from-a-mendelian-randomization-analysis
#14
Johan H Bjørngaard, Ask Tybjærg Nordestgaard, Amy E Taylor, Jorien L Treur, Maiken E Gabrielsen, Marcus R Munafò, Børge Grønne Nordestgaard, Bjørn Olav Åsvold, Pål Romundstad, George Davey Smith
Background: There is evidence for a positive relationship between cigarette and coffee consumption in smokers. Cigarette smoke increases metabolism of caffeine, so this may represent a causal effect of smoking on caffeine intake. Methods: We performed Mendelian randomization analyses in the UK Biobank ( N  = 114 029), the Norwegian HUNT study ( N  = 56 664) and the Copenhagen General Population Study (CGPS) ( N  = 78 650). We used the rs16969968 genetic variant as a proxy for smoking heaviness in all studies and rs4410790 and rs2472297 as proxies for coffee consumption in UK Biobank and CGPS...
August 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29022246/alpha-lipoic-acid-mitigates-toxic-induced-demyelination-in-the-corpus-callosum-by-lessening-of-oxidative-stress-and-stimulation-of-polydendrocytes-proliferation
#15
Nima Sanadgol, Fereshteh Golab, Hassan Askari, Fatemeh Moradi, Marziyeh Ajdary, Mehdi Mehdizadeh
Multiple Sclerosis (MS), is a disease that degenerates myelin in central nervous system (CNS). Reactive oxygen species (ROSs) are toxic metabolites, and accumulating data indicate that ROSs-mediated apoptosis of oligodendrocytes (OLGs) plays a major role in the pathogenesis of MS under oxidative stress conditions. In this study, we investigated the role of endogenous antioxidant alpha-lipoic acid (ALA) as ROSs scavenger in the OLGs loss and myelin degeneration during cuprizone (cup)-induced demyelination in the experimental model of MS...
October 12, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29020139/coffee-intake-and-incidence-of-erectile-dysfunction
#16
David S Lopez, Lydia Liu, Eric B Rimm, Konstantinos K Tsilidis, Marcia de Oliveira Otto, Run Wang, Steven Canfield, Edward Giovannucci
Coffee intake is suggested to have a positive role against chronic diseases. Yet, the role of coffee in urological diseases such as erectile dysfunction (ED) remains unclear. Thus, we investigated the association of coffee intake with incidence of ED.A prospective analysis of 21,403 men aged 40-75 years old was conducted using the Health Professionals Follow-Up Study. Total coffee, regular and decaffeinated coffee intakes were self-reported on food-frequency questionnaires. ED was assessed by means of questionnaires in 2000, 2004 and 2008...
August 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28988655/agricultural-experiences-are-positively-associated-with-high-school-students-fruit-and-vegetable-perceptions-and-consumption
#17
Anna E Greer, Stacey Davis, Cristina Sandolo, Nicole Gaudet, Brianna Castrogivanni
OBJECTIVE: To examine the relationship between high school students' agricultural experiences and their (1) attitudes about consuming local fruits and vegetables, (2) willingness to try new fruits and vegetables, and (3) fruit and vegetable consumption. DESIGN: Cross-sectional survey research. SETTING: Public high schools in a lower-income, diverse, urban, northeastern community. PARTICIPANTS: A total of 327 students from 3 public high schools...
October 4, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28977975/prognostic-clinicopathologic-factors-in-carcinoma-of-unknown-primary-origin-a-study-of-106-consecutive-cases
#18
Junjeong Choi, Ji Hae Nahm, Sang Kyum Kim
A heterogeneous group of cancers for which the site of origin remains occult after detailed investigations is defined as carcinomas of unknown primary origin (CUPs). Because patients with CUP have a dismal prognosis, we have analyzed CUPs to highlight the implication of clinicopathologic factors related with patient survival. A total of 106 consecutive cases of CUP were collected. A two-step strategy of immunohistochemistry to assess CUPs according NCCN Guidelines is used to separate carcinomatous tumors and subtype carcinomas...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28954544/two-year-outcomes-of-the-enabling-mothers-to-prevent-pediatric-obesity-through-web-based-education-and-reciprocal-determinism-empower-randomized-control-trial
#19
Adam P Knowlden, Eric Conrad
BACKGROUND: Childhood overweight and obesity is a public health epidemic with far-reaching medical, economic, and quality of life consequences. Brief, web-based interventions have received increased attention for their potential to combat childhood obesity. The purpose of our study was to evaluate a web-based, maternal-facilitated childhood obesity prevention intervention dubbed Enabling Mothers to Prevent Pediatric Obesity Through Web-Based Education and Reciprocal Determinism (EMPOWER), for its capacity to elicit sustained effects at the 2-year postintervention follow-up mark...
September 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28951281/outcomes-of-cup-revision-for-ilio-psoas-impingement-after-total-hip-arthroplasty-retrospective-study-of-46-patients
#20
C Batailler, N Bonin, M Wettstein, A Nogier, S Martres, E Ollier, O May, S Lustig
BACKGROUND: Impingement of the ilio-psoas tendon on the acetabular component is a cause of pain after total hip arthroplasty (THA). Studies of cup revision for ilio-psoas impingement (IPI) are scarce and limited in size. We therefore conducted a large multicentre retrospective study with the following objectives: to assess the effectiveness of cup replacement in resolving the impingement syndrome, to determine the frequency and nature of complications after cup revision for IPI, and to identify pre-operative factors associated with good outcomes of cup revision for IPI...
September 22, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
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