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https://www.readbyqxmd.com/read/28527220/quantitative-erythrocyte-omega-3-epa-plus-dha-levels-are-related-to-higher-regional-cerebral-blood-flow-on-brain-spect
#1
Daniel G Amen, William S Harris, Parris M Kidd, Somayeh Meysami, Cyrus A Raji
BACKGROUND: The interrelationships between omega-3 fatty acids status, brain perfusion, and cognition are not well understood. OBJECTIVE: To evaluate if SPECT brain imaging of cerebral perfusion and cognition varies as a function of omega-3 fatty acid levels. METHODS: A random sample of 166 study participants was drawn from a psychiatric referral clinical for which erythrocyte quantification of omega-3 eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (the Omega-3 Index) was available...
May 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28526351/docosahexaenoyl-serotonin-emerges-as-most-potent-inhibitor-of-il-17-and-ccl-20-released-by-blood-mononuclear-cells-from-a-series-of-n-acyl-serotonins-identified-in-human-intestinal-tissue
#2
Ya Wang, Michiel G J Balvers, Henk F J Hendriks, Tessa Wilpshaar, Tjarda van Heek, Renger F Witkamp, Jocelijn Meijerink
Fatty acid amides (FAAs), conjugates of fatty acids with ethanolamine, mono-amine neurotransmitters or amino acids are a class of molecules that display diverse functional roles in different cells and tissues. Recently we reported that one of the serotonin-fatty acid conjugates, docosahexaenoyl serotonin (DHA-5-HT), previously found in gut tissue of mouse and pig, attenuates the IL-23-IL-17 signaling axis in LPS-stimulated mice macrophages. However, its presence and effects in humans remained to be elucidated...
May 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28526084/liver-phospholipids-fatty-acids-composition-in-response-to-different-types-of-diets-in-rats-of-both-sexes
#3
Slavica Ranković, Tamara Popović, Jasmina Debeljak Martačić, Snježana Petrović, Mirko Tomić, Đurđica Ignjatović, Gordana Tovilović-Kovačević, Maria Glibetić
BACKGROUND: Dietary intake influence changes in fatty acids (FA) profiles in liver which plays a central role in fatty acid metabolism, triacylglycerol synthesis and energy homeostasis. We investigated the effects of 4-weeks treatment with milk- and fish-based diet, on plasma biochemical parameters and FA composition of liver phospholipids (PL) in rats of both sexes. METHODS: Adult, 4 months old, Wistar rats of both sexes, were fed with different types of diets: standard, milk-based and fish-based, during 4 weeks...
May 19, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28520867/activity-of-ceftolozane-tazobactam-against-surveillance-and-problem-enterobacteriaceae-pseudomonas-aeruginosa-and-non-fermenters-from-the-british-isles
#4
David M Livermore, Shazad Mushtaq, Daniele Meunier, Katie L Hopkins, Robert Hill, Rachael Adkin, Aiysha Chaudhry, Rachel Pike, Peter Staves, Neil Woodford
Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against 'problem' isolates sent to the UK national reference laboratory from July 2015, when routine testing began. Methods: Susceptibility testing was by BSAC agar dilution with resistance mechanisms identified by PCR and interpretive reading. Results: Data were reviewed for 6080 BSAC surveillance isolates and 5473 referred organisms...
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28517974/the-impact-of-docosahexaenoic-acid-therapy-on-subgingival-plaque-microbiota
#5
Asghar Z Naqvi, Lin Mu, Hatice Hasturk, Thomas E Van Dyke, Kenneth J Mukamal, J Max Goodson
OBJECTIVE: The aim of this study was to evaluate the impact of docosahexaenoic acid (DHA) with low-dose aspirin therapy on periodontal bacterial profile in patients with periodontitis. BACKGROUND: We recently showed that oral DHA + aspirin therapy reduces periodontal pocket depth and local inflammatory mediators in gingival crevicular fluid (GCF) among patients with untreated chronic periodontal disease. Whether or not DHA + aspirin therapy influences specific bacterial burden in this setting is unknown...
May 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28515069/mendelian-randomization-shows-sex-specific-associations-between-long-chain-pufa-related-genotypes-and-cognitive-performance-in-danish-schoolchildren
#6
Lotte Lauritzen, Louise B Sørensen, Laurine B Harsløf, Christian Ritz, Ken D Stark, Arne Astrup, Camilla B Dyssegaard, Niels Egelund, Kim F Michaelsen, Camilla T Damsgaard
Background: Dietary and endogenously formed long-chain polyunsaturated fatty acids (LCPUFAs) are hypothesized to improve cognitive development, but results are inconclusive, with suggestions of sex specificity. One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28515020/supplementation-with-high-dose-docosahexaenoic-acid-increases-the-omega-3-index-more-than-high-dose-eicosapentaenoic-acid
#7
Janie Allaire, William S Harris, Cécile Vors, Amélie Charest, Johanne Marin, Kristina Harris Jackson, André Tchernof, Patrick Couture, Benoît Lamarche
BACKGROUND: Recent studies suggest that eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have distinct effects on cardiometabolic risk factors. The Omega-3 Index (O3I), which is calculated as the proportion of EPA and DHA in red blood cell (RBC) membranes, has been inversely associated with the risk of coronary heart diseases and coronary mortality. The objective of this study was to compare the effects of EPA and DHA supplementation on the O3I in men and women with abdominal obesity and subclinical inflammation...
May 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28511406/effect-of-sodium-valproate-and-docosahexaenoic-acid-on-pain-in-rats
#8
REVIEW
Sushil Kiran Kunder, Laxminarayana Kurady Bairy, Avinash Arivazhahan
INTRODUCTION: Analgesics are commonly prescribed medications used to alleviate pain of various aetiologies without affecting the patient's consciousness. They interfere with the transmission of pain signals. A commonly used antiepileptic drug, sodium valproate has been used in various non-epileptic conditions like migraine prophylaxis and in the treatment of bipolar disorder because of the multiple mechanisms by which it acts. Docosahexanoic Acid (DHA), an omega 3 fatty acid, is known to possess analgesic activity...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511049/the-omega-3-index-and-relative-risk-for-coronary-heart-disease-mortality-estimation-from-10-cohort-studies
#9
William S Harris, Liana Del Gobbo, Nathan L Tintle
BACKGROUND AND AIMS: A recent 19-cohort meta-analysis examined the relationships between biomarkers of omega-3 fatty acids and risk for coronary heart disease (CHD). That study did not, however, report hazard ratios (HRs) specifically as a function of erythrocyte eicosapentaenoic (EPA) plus docosahexaenoic (DHA) levels, a metric called the Omega-3 Index in which EPA + DHA content is expressed as a percent of total fatty acids. The Omega-3 Index has been used in several recent studies and is a validated biomarker of omega-3 fatty acid tissue levels, but additional data are needed to confirm (or refute) the originally-proposed clinical cut-points of <4% (higher risk) and 8%-12% (lower risk)...
May 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28511023/efficacy-of-docosahexaenoic-acid-choline-vitamin-e-dha-cho-ve-in-paediatric-nash-a-randomized-controlled-clinical-trial
#10
Evelyn Zöhrer, Alisi Anna, Jörg Jahnel, Antonella Moscla, Claudia Della Corte, Annalisa Crudele, Günter Fauler, Valerio Nobili
Non-alcoholic steatohepatitis (NASH), a progressive form of non-alcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in children. We conducted a randomized controlled clinical trial on children with biopsy-proven NASH based on a combinatorial nutritional approach compared to placebo. Participants were assigned to lifestyle modification plus placebo, or lifestyle modification plus a mix containing docosahexaenoic acid, choline and vitamin E (DHA-CHO-VE). Forty children and adolescents concluded the trial...
May 16, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28503432/nutrient-patterns-and-risk-of-cataract-a-case-control-study
#11
Fatemeh Sedaghat, Matin Ghanavati, Parisa Nezhad Hajian, Sara Hajishirazi, Mehdi Ehteshami, Bahram Rashidkhani
AIM: To assess the relation between nutrient patterns and cataract risk. METHODS: This is a hospital-based case-control study with 97 cataract patients and 198 matched controls. Dietary consumption was collected through a valid food frequency questionnaire (FFQ). Nutrient patterns were detected by applying factor analysis. Unconditional logistic regression models were used to estimate odds ratio (ORs) and 95%CIs. RESULTS: We extracted 5 main nutrient patterns...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28502503/the-effects-of-vitamin-d-and-omega-3-fatty-acid-co-supplementation-on-glycemic-control-and-lipid-concentrations-in-patients-with-gestational-diabetes
#12
Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Teibeh Hashemi, Mohsen Taghizadeh, Maryamalsadat Razavi, Marzieh Sanami, Zatollah Asemi
OBJECTIVE: This study was performed to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on glucose metabolism and lipid concentrations in gestational diabetes (GDM) patients. METHODS: This randomized double-blind placebo-controlled clinical trial was done among 140 GDM patients. Participants were randomly divided into 4 groups to receive: (1) 1000 mg omega-3 fatty acids containing 360 mg eicosapentaenoic acid and 240 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 35); (2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 35); (3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 35), and (4) vitamin D placebo + omega-3 fatty acids placebo (n = 35) for 6 weeks...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28502496/minimal-food-effect-for-eicosapentaenoic-acid-and-docosahexaenoic-acid-bioavailability-from-omega-3-acid-ethyl-esters-with-an-advanced-lipid-technologies-tm-alt-%C3%A2-based-formulation
#13
Miguel A Lopez-Toledano, Thorsteinn Thorsteinsson, Ahmed A Daak, Kevin C Maki, Colleen Johns, Adrian L Rabinowicz, Frederick D Sancilio
BACKGROUND: The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) omega-3-acid ethyl esters (EEs) is influenced by food. There is a need for a formulation of EE that is less impacted by food effect. SC401 is a novel Advanced Lipid Technologies-based formulation of EPA-EE and DHA-EE. In the presence of an aqueous medium, Advanced Lipid Technologies forms stable micelles in situ independent of bile salt secretion. This effect is hypothesized to improve EPA-EE and DHA-EE bioavailability while it helps mitigate the food effect associated with their consumption...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28500069/b-cell-activity-is-impaired-in-human-and-mouse-obesity-and-is-responsive-to-an-essential-fatty-acid-upon-murine-influenza-infection
#14
Rasagna Kosaraju, William Guesdon, Miranda J Crouch, Heather L Teague, E Madison Sullivan, Erik A Karlsson, Stacey Schultz-Cherry, Kymberly Gowdy, Lance C Bridges, Lauren R Reese, P Darrell Neufer, Michael Armstrong, Nichole Reisdorph, J Justin Milner, Melinda Beck, Saame Raza Shaikh
Obesity is associated with increased risk for infections and poor responses to vaccinations, which may be due to compromised B cell function. However, there is limited information about the influence of obesity on B cell function and underlying factors that modulate B cell responses. Therefore, we studied B cell cytokine secretion and/or Ab production across obesity models. In obese humans, B cell IL-6 secretion was lowered and IgM levels were elevated upon ex vivo anti-BCR/TLR9 stimulation. In murine obesity induced by a high fat diet, ex vivo IgM and IgG were elevated with unstimulated B cells...
May 12, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28498397/dihydroartemisinin-inhibits-the-viability-of-cervical-cancer-cells-by-upregulating-caveolin%C3%A2-1-and-mitochondrial-carrier-homolog%C3%A2-2-involvement-of-p53-activation-and-nad-p-h-quinone-oxidoreductase%C3%A2-1-downregulation
#15
Ting Zhang, Yuan Hu, Ting Wang, Peiling Cai
Dihydroartemisinin (DHA) has been shown to inhibit the viability of various cancer cells. Previous studies have revealed that the mechanisms involved in the inhibitory effects of DHA are based on theactivation of p53 and the mitochondrial-related cell death pathway. However, the exact association between upstream signaling and the activation of cell death pathway remains unclear. In this study, we found that DHA treatment induced the upregulation of caveolin 1 (Cav1) and mitochondrial carrier homolog 2 (MTCH2) in HeLa cells, and this was associated with the DHA-induced inhibition of cell viability and DHA-induced apoptosis...
May 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28497479/proximate-composition-amino-acid-and-fatty-acid-profiles-of-marine-snail-rapana-venosa-meat-visceral-mass-and-operculum
#16
Fenglei Luo, Ronge Xing, Xueqin Wang, Quancai Peng, Pengcheng Li
BACKGROUND: Rapana venosa (Rv), an important marine snail, presents increasing nutritional, and economic importance. However, there still has been limited information on their nutritional composition. This study highlighted and provided new information on the proximate composition, amino acids and fatty acids profiles of Rv different body parts in order to its better application and research. RESULTS: The operculum contained high amount of protein and flavor amino acids...
May 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28497355/the-generation-of-dehydroalanine-residues-in-protonated-polypeptides-ion-ion-reactions-for-introducing-selective-cleavages
#17
Zhou Peng, Jiexun Bu, Scott A McLuckey
We examine a gas-phase approach for converting a subset of amino acid residues in polypeptide cations to dehydroalanine (Dha). Subsequent activation of the modified polypeptide ions gives rise to specific cleavage N-terminal to the Dha residue. This process allows for the incorporation of selective cleavages in the structural characterization of polypeptide ions. An ion/ion reaction within the mass spectrometer between a multiply protonated polypeptide and the sulfate radical anion introduces a radical site into the multiply protonated polypeptide reactant...
May 11, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28495596/the-role-of-omega-3-and-omega-9-fatty-acids-for-the-treatment-of-neuropathic-pain-after-neurotrauma
#18
REVIEW
Iriana Galán-Arriero, Diego Serrano-Muñoz, Julio Gómez-Soriano, Carlos Goicoechea, Julian Taylor, Ana Velasco, Gerardo Ávila-Martín
Omega-3 polyunsaturated fatty acids (PUFAs), such as Docosaexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA), mediate neuroactive effects in experimental models of traumatic peripheral nerve and spinal cord injury. Cellular mechanisms of PUFAs include reduced neuroinflammation and oxidative stress, enhanced neurotrophic support, and activation of cell survival pathways. Bioactive omega-9 monounsaturated fatty acids, such as Oleic Acid (OA) and 2-Hydroxy Oleic Acid (2-OHOA), also show therapeutic effects in neurotrauma models...
May 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28490123/kinetics-of-conversion-of-dihydroxyacetone-to-methylglyoxal-in-new-zealand-m%C3%A4-nuka-honey-part-iv-formation-of-hmf
#19
Megan N C Grainger, Adrian Owens, Merilyn Manley-Harris, Joseph R Lane, Richard J Field
During a study of the conversion of dihydroxyacetone (DHA) to methylglyoxal (MGO) in maturing New Zealand mānuka honey, the kinetics of formation of 5-(hydroxymethyl)furfural (HMF) was studied at temperatures from 4 to 37°C. Formation of HMF was first-order during an induction period and zero-order thereafter indicating that the mechanism includes the formation of certain critical intermediates and that these require time to build up; the duration of the induction period depended primarily upon temperature...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28490059/lipid-classes-and-fatty-acids-composition-of-the-roe-of-wild-silurus-glanis-from-subalpine-freshwater
#20
Francesco Saliu, Barbara Leoni, Roberto Della Pergola
The fat content and the fatty acid composition of the roe of European catfish (Silurus glanis) wild specimens captured in the Lambro river basin (Como, Northern Italy) were investigated in order to assess their nutritional value. Total extracted lipid values on roe weight were 5.8-6.3%. Phospholipids (40.2-43.6%) and triacylglycerols (31.8-34.7%) were the most represented lipid classes. Relevant amount of cholesteryl esters (14.3-15.6%) were also detected. The main fatty acids were palmitic, oleic and cis-4,7,10,13,16,19-docosahexaenoic acid (DHA)...
October 1, 2017: Food Chemistry
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