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https://www.readbyqxmd.com/read/27903279/in-vitro-and-in-vivo-anti-malarial-activity-of-novel-harmine-analog-heat-shock-protein-90-inhibitors-a-possible-partner-for-artemisinin
#1
Abebe Genetu Bayih, Asongna Folefoc, Abu Naser Mohon, Scott Eagon, Marc Anderson, Dylan R Pillai
BACKGROUND: The emergence of artemisinin-resistant Plasmodium falciparum strains poses a serious challenge to the control of malaria. This necessitates the development of new anti-malarial drugs. Previous studies have shown that the natural beta-carboline alkaloid harmine is a promising anti-malarial agent targeting the P. falciparum heat-shock protein 90 (PfHsp90). The aim of this study was to test the anti-malarial activity of harmine analogues. METHODS: Forty-two harmine analogues were synthesized and the binding of these analogues to P...
December 1, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27902774/intravenous-treatment-with-a-long-chain-omega-3-lipid-emulsion-provides-neuroprotection-in-a-murine-model-of-ischemic-stroke-a-pilot-study
#2
Dirk Berressem, Konrad Koch, Nicole Franke, Jochen Klein, Gunter P Eckert
Single long-chain omega-3 fatty acids (e.g. docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA)) are known for their neuroprotective properties associated with ischemic stroke. This pilot study aimed to test the effectiveness of an acute treatment with a long-chain omega-3 lipid emulsion (Omegaven 10%®, OGV) that contains fish oil (DHA 18 mg/ml; EPA 21 mg/ml) and α-tocopherol (0.2 mg/ml) in a transient middle cerebral artery occlusion (MCAO) model of ischemic stroke in mice. For this purpose, female CD-1 mice were anesthetized and subjected to 90 minutes of MCAO...
2016: PloS One
https://www.readbyqxmd.com/read/27902293/colwellia-marinimaniae-sp-nov-a-hyperpiezophilic-species-isolated-from-an-amphipod-within-the-challenger-deep-mariana-trench
#3
Masataka Kusube, Than S Kyaw, Kumiko Tanikawa, Roger A Chastain, Kevin Hardy, James Cameron, Douglas H Bartlett
An obligately piezophilic strain was isolated from an amphipod crustacean obtained in the Challenger Deep region of the Mariana Trench during the DEEPSEA CHALLENGE expedition. The strain, MTCD1T, grew at extremely high hydrostatic pressures, with a growth range of 80-140 MPa (optimum: 120 MPa) at 6°C. Phylogenetic analyses based on the 16S rRNA gene sequence indicates that it is closely affiliated with the genus Colwellia. Comparative 16S rRNA gene sequence analyses revealed 95.7%, 95.5%, and 95.2% similarity to Colwellia maris ABE-1T, Colwellia piezophila Y233GT, and Colwellia psychrerythraea 34HT, respectively...
November 16, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900057/in-vitro-and-in-vivo-inhibition-of-tumor-cell-viability-by-combined-dihydroartemisinin-and-doxorubicin-treatment-and-the-underlying-mechanism
#4
Xiang Tai, Xiao-Bei Cai, Zhang Zhang, Rui Wei
The natural extract artemisinin and its derivatives have good anticancer activity. The present study aimed to investigate the in vitro inhibitory effects of combined dihydroartemisinin (DHA) and doxorubicin (DOX) treatment on a variety of tumor cell lines (HeLa, OVCAR-3, MCF-7, PC-3 and A549), as well as the underlying mechanisms. In addition, the in vivo effects of DHA and DOX were evaluated using a mouse HeLa tumor model. The HeLa, OVCAR-3, MCF-7, PC-3 and A549 cells were treated with a combination of DHA and DOX, and the effect on cell viability was detected by Cell Counting kit-8...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27896916/dihydroartemisinin-counteracts-fibrotic-portal-hypertension-via-farnesoid-x-receptor-dependent-inhibition-of-hepatic-stellate-cell-contraction
#5
Wenxuan Xu, Chunfeng Lu, Feng Zhang, Jiangjuan Shao, Shunyu Yao, Shizhong Zheng
Portal hypertension is a frequent pathological symptom occurring especially in hepatic fibrosis and cirrhosis. Current paradigms indicate that inhibition of hepatic stellate cell (HSC) activation and contraction is anticipated to be an attractive therapeutic strategy, because activated HSC dominantly facilitates an increase in intrahepatic vein pressure through secreting extracellular matrix and contracting. Our previous in vitro study indicated that dihydroartemisinin (DHA) inhibited contractility of cultured HSC by activating intracellular farnesoid X receptor (FXR)...
November 7, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27895313/repurposing-the-anti-malarial-drug-dihydroartemisinin-suppresses-metastasis-of-non-small-cell-lung-cancer-via-inhibiting-nf-%C3%AE%C2%BAb-glut1-axis
#6
Jie Jiang, Guojun Geng, Xiuyi Yu, Hongming Liu, Jing Gao, Hanxiang An, Chengfu Cai, Ning Li, Dongyan Shen, Xiaoqiang Wu, Lisheng Zheng, Yanjun Mi, Shuyu Yang
Non-small-cell lung cancer (NSCLC) is an aggressive malignancy and long-term survival remains unsatisfactory for patients with metastatic and recurrent disease. Repurposing the anti-malarial drug dihydroartemisinin (DHA) has been proved to possess potent antitumor effect on various cancers. However, the effects of DHA in preventing the invasion of NSCLC cells have not been studied. In the present study, we determined the inhibitory effects of DHA on invasion and migration and the possible mechanisms involved using A549 and H1975 cells...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27887614/insight-into-k13-propeller-gene-polymorphism-and-ex-vivo-dha-response-profiles-from-cameroonian-isolates
#7
Sandie Menard, Joëlle Njila Tchoufack, Christelle Ngou Maffo, Sandrine E Nsango, Xavier Iriart, Luc Abate, Majoline Tchioffo Tsapi, Parfait H Awono-Ambéné, Francis A Abega Mekongo, Isabelle Morlais, Antoine Berry
BACKGROUND: The spread of Plasmodium falciparum resistance to artemisinin derivatives in Southeast Asia is a major source of concern and the emergence of resistance in Africa would have dramatic consequences, by increasing malaria mortality and morbidity. It is therefore urgent to implement regular monitoring in sentinel sites in sub-Saharan Africa using robust and easy-to-implement tools. The prevalence of k13-propeller mutations and the phenotypic profiles are poorly known in sub-Saharan Africa...
November 26, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27887602/combination-of-aspirin-with-essential-fatty-acids-is-superior-to-aspirin-alone-to-prevent-or-ameliorate-sepsis-or-ards
#8
EDITORIAL
Undurti N Das
It has been suggested that aspirin may be of benefit in treating sepsis and ARDS in view of its ability to block cyclo-oxygenase-1 (COX-1) and COX-2 activities; inhibit nuclear factor kappa B (NF-κB); enhance the production of endothelial nitric oxide (eNO) and lipoxin A4 (LXA4). Our previous studies revealed that plasma phospholipid content of arachidonic acid (AA) and eicosapentaenoic acid (EPA) is low in patients with sepsis. This implies that beneficial actions of aspirin in sepsis and ARDS is unlikely to be obtained in view of deficiency of AA and EPA, the precursors of LXA4 and resolvins respectively that are potent anti-inflammatory compounds and enhancers of eNO generation...
November 25, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27886534/differences-in-the-response-of-soil-dehydrogenase-activity-to-cd-contamination-are-determined-by-the-different-substrates-used-for-its-determination
#9
Xiangping Tan, Yanju Liu, Kaihong Yan, Ziquan Wang, Guannan Lu, Yike He, Wenxiang He
Dehydrogenase activity (DHA) is an important indicator of heavy metal toxicity in contaminated soils. Different instances of DHA were determined using various substrates and which could affect the description of heavy metal toxicity. Currently, too few investigations have been done on selecting appropriate substrates. This study employed indoor simulation to determine soil DHA and its response to external cadmium (Cd) using two substrates (TTC and INT). Hormesis for DHA obtained using the TTC method (DHA-TTC) in low Cd concentration was observed which was quickly inhibited in high Cd concentration...
November 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/27884184/dietary-patterns-of-early-childhood-and-maternal-socioeconomic-status-in-a-unique-prospective-sample-from-a-randomized-controlled-trial-of-prenatal-dha-supplementation
#10
Brandon H Hidaka, Elizabeth H Kerling, Jocelynn M Thodosoff, Debra K Sullivan, John Colombo, Susan E Carlson
BACKGROUND: Dietary habits established in early childhood and maternal socioeconomic status (SES) are important, complex, interrelated factors that influence a child's growth and development. The aim of this study was to define the major dietary patterns in a cohort of young US children, construct a maternal SES index, and evaluate their associations. METHODS: The diets of 190 children from a randomized, controlled trial of prenatal supplementation of docosahexaenoic acid (DHA) were recorded at 6-mo intervals from 2-4...
November 25, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27884155/long-chain-polyunsaturated-fatty-acids-lcpufas-and-nordihydroguaiaretic-acid-ndga-modulate-metabolic-and-inflammatory-markers-in-a-spontaneous-type-2-diabetes-mellitus-model-stillman-salgado-rats
#11
Alejandro Dain, Gaston Repossi, Gustavo T Diaz-Gerevini, Jairam Vanamala, Undurti N Das, Aldo R Eynard
BACKGROUND: Diabetes mellitus (DM) is a complex disease with alterations in metabolic and inflammatory markers. Stillman Salgado rats (eSS) spontaneously develop type 2 DM by middle age showing progressive impairment of glucose tolerance with hyperglycemia, hypertriglyceridemia and hyperinsulinemia. We analyzed the effects of supplementation of ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) with or without nordihydroguaiaretic acid (NDGA) added, an antioxidant and lipoxygenase inhibitor, on metabolic and inflammatory parameters in eSS rats to evaluate whether they can delay development and/or prevent progression of DM...
November 25, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27883019/17-oxo-dha-displays-additive-anti-inflammatory-effects-with-fluticasone-propionate-and-inhibits-the-nlrp3-inflammasome
#12
Chiara Cipollina, Serena Di Vincenzo, Liboria Siena, Caterina Di Sano, Mark Gjomarkaj, Elisabetta Pace
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function associated with increased local and systemic inflammatory markers, such as TNFα and IL-1β. Glucocorticoids are used to treat this chronic disease, however their efficacy is low and new drugs are very much required. 17-oxo-DHA is a cyclooxygenase-2-dependent, electrophilic, α,β-unsaturated keto-derivative of docosahexaenoic acid with anti-inflammatory properties. We evaluated the action of 17-oxo-DHA alone or in combination with the steroid fluticasone propionate (FP) in peripheral blood mononuclear cells (PBMCs) from COPD patients and healthy individuals exposed to lipopolysaccharide...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27881290/mercury-eicosapentanoic-acid-and-docosahexaenoic-acid-demonstrate-limited-effect-on-plasma-paraoxonase-1-activity-and-blood-pressure-among-avid-seafood-consumers-in-the-long-island-study-of-seafood-consumption-ny-usa
#13
Charles Miller, Roxanne Karimi, Qiao Zhang, Jie Yang, Jaymie Meliker
BACKGROUND AND AIM: Moderate fish consumption is recommended for prevention of coronary heart disease (CHD) as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have known beneficial effects on risk factors such as reducing blood pressure (BP) and increasing paraoxonase-1 (PON-1) activity. However concomitant methylmercury (MeHg) exposure from fish consumption may mitigate these benefits and the net effect on BP and PON-1 activity has not been extensively studied in western populations consuming diverse seafood types...
November 17, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27881040/a-single-dose-of-docosahexaenoic-acid-increases-the-functional-recovery-promoted-by-rehabilitation-following-cervical-spinal-cord-injury-in-the-rat
#14
Zhuo-Hao Liu, Ping Yip, John V Priestley, Adina T Michael-Titus
Task-specific rehabilitation has been shown to promote functional recovery after acute spinal cord injury (SCI). Recently, the omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), has been shown to promote neuroplasticity after SCI. Here, we investigated whether the combination of a single bolus of DHA with rehabilitation can enhance the effect of DHA or rehabilitation therapy in adult injured spinal cord. We found enhanced functional improvement with DHA in combination with rehabilitation compared to either treatment alone in a rat cervical lateral hemisection SCI model...
November 23, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27880795/the-association-of-fatty-acid-levels-and-gleason-grade-among-men-undergoing-radical-prostatectomy
#15
Zhiguo Zhao, Lael Reinstatler, Zachary Klaassen, Yi Xu, Xiaoyu Yang, Rabii Madi, Martha K Terris, Steven Y Qian, Uddhav Kelavkar, Kelvin A Moses
BACKGROUND: Epidemiological data suggest that omega-6 (ω-6) fatty acids (FAs) may be associated with cancer incidence and/or cancer mortality, whereas ω-3 FAs are potentially protective. We examined the association of the ratio of ω-6 to ω-3 FA (ω-6:ω-3) and individual FA components with pathological results among men with prostate cancer (PCa) undergoing radical prostatectomy. METHODS: Sixty-nine men were included in the study. Components of ω-6 (linoleic acid (LA), arachidonic acid (AA), and dihomo-γ-linolenic acid (DGLA)) and ω-3 (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) were analyzed by liquid chromatography/mass selective detector separation...
2016: PloS One
https://www.readbyqxmd.com/read/27880058/fish-oil-derived-dha-mediated-enhancement-of-apoptosis-in-acute-lymphoblastic-leukemia-cells-is-associated-with-accumulation-of-p53-downregulation-of-survivin-and-caspase-3-activation
#16
Mohammad Reza Sam, Mohammad Esmaeillou, Mohammad Ali Shokrgozar
In acute lymphoblastic leukemia (ALL), resistance to chemotherapy is associated with inactivation of p53 and upregulation of survivin. Thus, targeting the p53 and survivin expression may provide an attractive strategy for ALL treatment. It has been shown that fish-oil-derived docosahexaenoic acid (DHA) activates several antitumorigenic mechanisms in tumor cells, but little is known regarding the role of DHA on modulating p53 and survivin expression in ALL cells. In this study, we investigated the alterations of the p53 and survivin expression and induction of apoptosis in DHA-treated Molt-4 cells that serve as a model for ALL cells...
November 23, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27880046/docosahexaenoic-acid-mediated-inhibition-of-heat-shock-protein-90-p23-chaperone-complex-and-downstream-client-proteins-in-lung-and-breast-cancer
#17
Michael Mouradian, Irvin V Ma, Erika D Vicente, Keith D Kikawa, Ronald S Pardini
The molecular chaperone, heat shock protein 90 (Hsp90), is a critical regulator for the proper folding and stabilization of several client proteins, and is a major contributor to carcinogenesis. Specific Hsp90 inhibitors have been designed to target the ATP-binding site in order to prevent Hsp90 chaperone maturation. The current study investigated the effects of docosahexaenoic acid (DHA; C22:6 n-3) on Hsp90 function and downstream client protein expression. In vitro analyses of BT-474 human breast carcinoma and A549 human lung adenocarcinoma cell lines revealed dose-dependent decreases in intracellular ATP levels by DHA treatment, resulting in a significant reduction of Hsp90 and p23 association in both cell lines...
November 23, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27876761/early-infant-adipose-deposition-is-positively-associated-with-the-n-6-to-n-3-fatty-acid-ratio-in-human-milk-independent-of-maternal-bmi
#18
M C Rudolph, B E Young, D J Lemas, C E Palmer, T L Hernandez, L A Barbour, J E Friedman, N F Krebs, P S MacLean
BACKGROUND/OBJECTIVES: Excessive infant weight gain in the first 6-months of life is a powerful predictor of childhood obesity and related health risks. In mice, omega-6 fatty acids (FA) serve as potent ligands driving adipogenesis during early development. The ratio of omega-6 relative to omega-3 (n-6/n-3) FA in human milk (HM) has increased 3-fold over the last 30 years, but the impact of this shift on infant adipose development remains undetermined. This study investigated how maternal obesity and maternal dietary FA (as reflected in maternal red blood cells (RBC) composition) influenced HM n-6 and n-3 FAs, and whether the HM n-6/n-3 ratio was associated with changes in infant adipose deposition between 2-weeks and 4-months postpartum...
November 23, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27876710/enhancement-of-1-3-dihydroxyacetone-production-from-gluconobacter-oxydans-by-combined-mutagenesis
#19
Xi Lin, Sha Liu, Guangrong Xie, Jing Chen, Penghua Li, Jianhua Chen
Wild strain L-6 was subjected to combined mutagenesis, including UV irradiation, atmospheric and room temperature plasma, and ion beam implantation, to increase the yield of 1,3-dihydroxyacetone (DHA). With application of a high-throughput screening method, mutant Gluconobacter oxydans I-2-239 with a DHA productivity of 103.5 g/l in flask-shake fermentation was finally obtained with the starting glycerol concentration of 120 g/l, which was 115.7% higher than the wild strain. The cultivation time also decreased from 54 h to 36 h...
November 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27876051/dietary-marine-derived-long-chain-monounsaturated-fatty-acids-and-cardiovascular-disease-risk-a-mini-review
#20
REVIEW
Zhi-Hong Yang, Beatrice Emma-Okon, Alan T Remaley
Regular fish/fish oil consumption is widely recommended for protection against cardiovascular diseases (CVD). Fish and other marine life are rich sources of the cardioprotective long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (C20:5 n-3; EPA) and docosahexaenoic acid (C22:6 n-3; DHA). The lipid content and fatty acid profile of fish, however, vary greatly among different fish species. In addition to n-3 PUFA, certain fish, such as saury, pollock, and herring, also contain high levels of long-chain monounsaturated fatty acids (LCMUFA), with aliphatic tails longer than 18 C atoms (i...
November 22, 2016: Lipids in Health and Disease
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