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Nejm neurology

Jesper Kjaergaard, Niklas Nielsen, Matilde Winther-Jensen, Michael Wanscher, Tommaso Pellis, Michael Kuiper, Jakob Hartvig Thomsen, Jørn Wetterslev, Tobias Cronberg, John Bro-Jeppesen, David Erlinge, Hans Friberg, Helle Søholm, Yvan Gasche, Janneke Horn, Jan Hovdenes, Pascal Stammet, Matthew P Wise, Anders Åneman, Christian Hassager
AIM: Time to Return of Spontaneous Circulation (ROSC) has a plausible relation to severity of hypoxic injury before and during resuscitation in Out-of-Hospital Cardiac Arrest (OHCA), and has consistently been associated with adverse outcome. The effect of Targeted Temperature Management (TTM) may not be similar over the full spectrum of time to ROSC. This study investigated the possible beneficial effect of targeting 33°C over 36°C on the prognostic importance of time to ROSC. METHODS: In predefined sub-study of the TTM-trial (NEJM 2013) we investigated the relationship between time to ROSC, level of TTM and mortality and neurological outcome as assessed by the Cerebral Performance Category (CPC) scale and modified Rankin Scale (mRS) after 180 days...
November 2015: Resuscitation
Jean-Francois Gehanno, Joel Ladner, Laetitia Rollin, Badisse Dahamna, Stefan J Darmoni
BACKGROUND: General practitioners and medical specialists mainly rely on one "general medical" journal to keep their medical knowledge up to date. Nevertheless, it is not known if these journals display the same overview of the medical knowledge in different specialties. The aims of this study were to measure the relative weight of the different specialties in the major journals of general medicine, to evaluate the trends in these weights over a ten-year period and to compare the journals...
2011: BMC Medical Informatics and Decision Making
Andrea L Gropman
Mitochondrial disorders are caused by mutations of nuclear or mitochondrial DNA encoded genes involved in oxidative phosphorylation (OXPHOS). Mutations in these critical genes are associated with specific clinical syndromes with diverse presentations (DiMauro and Schon, 2003. NEJM 348, 2656; Hart et al., 2002. Mitochondrial Disorders in Neurology). Since mitochondria are present in many of our organs and play a key role in energy metabolism, mitochondrial encephalomyopathies often present as multisystem disorders which may manifest with neurologic, cardiac, endocrine, gastrointestinal, hepatic, renal and/or hematologic involvement (DiMauro and Bonilla, 1997...
September 2004: Mitochondrion
J Klepper, D Wang, J Fischbarg, J C Vera, I T Jarjour, K R O'Driscoll, D C De Vivo
Impaired glucose transport across brain tissue barriers causes infantile seizures, developmental delay and acquired microcephaly. Since the first report in 1991 (De Vivo et al, NEJM, 1991) 17 patients have been identified with the glucose transporter protein syndrome (GTPS). The diagnostic feature of the syndrome is an unexplained hypoglycorrhachia in the clinical setting of an infantile epileptic encephalopathy. We review our clinical experience by highlighting one illustrative case: a 6-year old girl who presented at age 2 months with infantile seizures and hypoglycorrhachia...
April 1999: Neurochemical Research
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