keyword
MENU ▼
Read by QxMD icon Read
search

Basophil

keyword
https://www.readbyqxmd.com/read/28220972/quantitative-distinction-of-the-morphological-characteristic-of-erythrocyte-precursor-cells-with-texture-analysis-using-gray-level-co-occurrence-matrix
#1
Keigo Kono, Ruka Hayata, Satoru Murakami, Mai Yamamoto, Maiko Kuroki, Kana Nanato, Kazuto Takahashi, Keiko Miwa, Yutaka Tsutsumi, Kazunori Okada, Sanae Kaga, Taisei Mikami, Nobuo Masauzi
BACKGROUND: Morphological characteristics of blood cells are still qualitatively defined. So a texture analysis (Tx) method using gray level co-occurrence matrices (GLCMs; CM-Tx method) was applied to images of erythrocyte precursor cells (EPCs) for quantitatively distinguishing four types of EPC stages: proerythroblast, basophilic erythroblast, polychromatic erythroblast, and orthochromatic erythroblast. METHODS: Fifty-five images of four types of EPCs were downloaded from an atlas uploaded by the Blood Cell Morphology Standardization Subcommittee (BCMSS) of the Japanese Society of Laboratory Hematology (JSLH)...
February 21, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28219062/the-impact-on-allergy-related-cells-of-a-birch-pollen-allergoid-with-and-without-monophosphoryl-lipid-a-in-comparison-with-the-native-equivalent
#2
Margitta Worm, Dennis Ernst, Markus Kraller, Magda Babina
BACKGROUND: The clinical efficacy and safety of allergoid immunotherapy have been demonstrated in clinical trials. However, simultaneous monitoring of the immunological changes by allergoids versus allergens in the cells of the same individual has not been extensively performed, and the impact of concurrent Toll-like receptor 4 (TLR4) ligation has not been specified. METHODS: Three types of birch allergen were utilized: glutaraldehyde-treated allergoid (extract A), the same allergoid plus monophosphoryl lipid A (MPL), i...
February 21, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28218466/bullous-pemphigoid-arising-in-a-patient-with-acquired-perforating-dermatosis
#3
S Tani, N Ishii, T Hashimoto, K Tsujioka
A middle-aged Japanese man who had been on haemodialysis treatment for diabetic nephropathy developed multiple itchy papules and nodules, which were histopathologically diagnosed as acquired perforating dermatosis. Two years later he developed oral lesions and subsequently numerous erosive plaques with necrotic crusts on the trunk and extremities. Histopathology of a papule showed a parakeratotic plug intermingled with basophilic, necrotic debris and collagen bundles, along with penetration of collagen bundles across the epidermis and subepidermal blister...
February 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28212503/lactobacillus-buchneri-s-layer-as-carrier-for-an-ara-h-2-derived-peptide-for-peanut-allergen-specific-immunotherapy
#4
Julia Anzengruber, Merima Bublin, Eva Bönisch, Bettina Janesch, Angelika Tscheppe, Matthias L Braun, Eva-Maria Varga, Christine Hafner, Heimo Breiteneder, Christina Schäffer
Peanut allergy is an IgE-mediated severe hypersensitivity disorder. The lack of a treatment of this potentially fatal allergy has led to intensive research on vaccine development. Here, we describe the design and initial characterization of a carrier-bound peptide derived from the most potent peanut allergen, Ara h 2, as a candidate vaccine. Based on the adjuvant capability of bacterial surface (S-) layers, a fusion protein of the S-layer protein SlpB from Lactobacillus buchneri CD034 and the Ara h 2-derived peptide AH3a42 was produced...
February 14, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28211870/non-apoptotic-functions-of-caspases-in-myeloid-cell-differentiation
#5
REVIEW
Stéphanie Solier, Michaela Fontenay, William Vainchenker, Nathalie Droin, Eric Solary
Subtle caspase activation is associated with the differentiation of several myeloid lineages. A tightly orchestrated dance between caspase-3 activation and the chaperone HSP70 that migrates to the nucleus to protect the master regulator GATA-1 from cleavage transiently occurs in basophilic erythroblasts and may prepare nucleus and organelle expel that occurs at the terminal phase of erythroid differentiation. A spatially restricted activation of caspase-3 occurs in maturing megakaryocytes to promote proplatelet maturation and platelet shedding in the bloodstream...
February 17, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28209657/demystification-of-enigma-on-antigen-presenting-cell-features-of-human-basophils-data-from-secondary-lymphoid-organs
#6
Emmanuel Stephen-Victor, Mrinmoy Das, Meenu Sharma, Caroline Galeotti, Hélène Fohrer-Ting, Boualem Sendid, Luc Darnige, Benoit Terris, Cécile Badoual, Patrick Bruneval, Srini V Kaveri, Jagadeesh Bayry
No abstract text is available yet for this article.
February 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28205377/culture-independent-genomics-of-a-novel-chlamydial-pathogen-of-fish-provides-new-insight-into-host-specific-adaptations-utilised-by-these-intracellular-bacteria
#7
Alyce Taylor-Brown, Trestan Pillonel, Andrew Bridle, Weihong Qi, Nathan Bachmann, Terrence L Miller, Gilbert Greub, Barbara Nowak, Helena M B Seth-Smith, Lloyd Vaughan, Adam Polkinghorne
Several Chlamydiales families are associated with epitheliocystis, a common condition of the fish gill epithelium. These families share common ancestors with the Chlamydiaceae and environmental Chlamydiae. Due to the lack of culture systems, little is known about the biology of these chlamydial fish pathogens. We investigated epitheliocystis in cultured Orange-spotted grouper (Epinephelus coioides) from North Queensland, Australia. Basophilic inclusions were present in the gills of 22/31 fish and the presence of the chlamydial pathogen in the cysts was confirmed by in situ hybridisation...
February 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28194756/chlorhexidine-allergy-in-4-specialist-allergy-centres-in-the-uk-2009-2013-clinical-features-and-diagnostic-tests
#8
William Egner, Matthew Helbert, Ravishankar Sargur, Kirsty Swallow, Nigel Harper, Tomaz Garcez, Sinisa Savic, Louise Savic, Eren Effren
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics in the UK following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and sIgE testing were the most common tests used for diagnosis. Fifty-three % of diagnoses were made on the basis of a single positive test. Where multiple tests were performed the sensitivity of intradermal, basophil activation and skin prick testing was 68% (50-86%), 50% (10-90%) and 35% (17-55%) respectively...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28190352/polyphenol-interactions-mitigate-the-immunogenicity-and-allergenicity-of-gliadins
#9
Maxime Perot, Roberta Lupi, Sylvain Guyot, Carine Delayre-Orthez, Pascale Gadonna-Widehem, Jean-Yves Thebaudin, Marie Bodinier, Colette Larre
Wheat allergy is an IgE-mediated disorder. Polyphenols, which are known to interact with certain proteins, could be used to reduce allergic reactions. In this study, we screened several polyphenol sources for their ability to interact with gliadins, mask epitopes and impact basophil degranulation. Polyphenol extracts from artichoke leaves, cranberries, apples and green tea leaves were examined. Of these extracts, the first three formed insoluble complexes with gliadins. Only the cranberry and apple extracts masked epitopes in dot blot assays using anti-gliadin IgG and IgE antibodies from patients with wheat allergies...
February 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28185161/the-skin-as-a-route-of-allergen-exposure-part-i-immune-components-and-mechanisms
#10
REVIEW
Anna R Smith, George Knaysi, Jeffrey M Wilson, Julia A Wisniewski
PURPOSE OF REVIEW: To highlight recent contributions in the literature that enhance our understanding of the cutaneous immune response to allergen. RECENT FINDINGS: Defects in skin barrier function in infancy set the stage for the development of atopic dermatitis (AD) and allergy. Both genetic and environmental factors can contribute to damage of the stratum corneum (SC), with activation of specific protease enzymes under high pH conditions playing a key role. Immune cells and mediators in the dermis and epidermis impair SC repair mechanisms and support allergy development...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28181328/protein-and-mrna-expression-of-follicle-stimulating-hormone-receptor-and-luteinizing-hormone-receptor-during-the-oestrus-in-the-yak-bos-grunniens
#11
S-D Huo, S-E Chen, R-J Long, J-T Yang, J-X Lu, R-X Zang, T-J Zhang, A Abudureyimu, J-L Liu, G-H Zhang, Y-Q Zhao, Z-R Ma
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) have a central role in follicle growth, maturation and oestrus, but no clear pathway in the seasonal oestrus of yak (Bos grunniens) has been found. To better understand the role of FSH and LH in seasonal oestrus in the yak, six yaks were slaughtered while in oestrus, and the pineal gland, hypothalamus, pituitary gland, and gonads were collected. Using real-time PCR and immunohistochemical assays, we determined the mRNA and protein expression of the FSH and LH receptors (FSHR and LHR) in these organs...
February 8, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28178894/adenocarcinoma-of-the-lung-metastatic-to-the-ovary-with-a-signet-ring-cell-component
#12
Giovanna Giordano, Nelly Cruz Viruel, Enrico Maria Silini, Francisco F Nogales
A nonsmoker 45-year-old woman, presented with a solid right ovarian mass. Microscopic examination revealed heterogeneous histology with tubular formations and extensive signet ring cell component that resembled the usual appearance of metastatic gastric carcinoma to the ovary. Moreover, the histology also showed solid nests of cells with a microvacuolated basophilic cytoplasm similar to those found in adenosquamous cervical carcinoma of glassy cell type. However, analysis of the patient's past history revealed a lung adenocarcinoma, diagnosed 4 years before, which prompted an immunohistochemical differential diagnosis, showing a strong expression for TTF-1 and Napsin A...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28167202/two-hemocyte-sub-populations-of-kuruma-shrimp-marsupenaeus-japonicus
#13
Keiichiro Koiwai, Rod Russel R Alenton, Reina Shiomi, Reiko Nozaki, Hidehiro Kondo, Ikuo Hirono
Hemocytes in the circulating hemolymph play important roles for immune responses in shrimp. Previous studies on immune responses by hemocytes in penaeid shrimp were based on gene expression analyses of the entire population of hemocytes and thus may have missed different immune responses of different hemocyte sub-populations. In this study, we separated hemocytes into two sub-populations by Percoll gradient centrifugation, morphological characteristics of each population were then analyzed by May-Giemsa staining, flow cytometry, and FACSCalibur...
February 3, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28166684/pathogenic-mechanisms-of-ige-mediated-inflammation-in-self-destructive-autoimmune-responses
#14
Rachel Ettinger, Jodi L Karnell, Jill Henault, Santosh K Panda, Jeffrey M Riggs, Roland Kolbeck, Miguel A Sanjuan
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. However, recently they have been recognized as active drivers of autoimmunity through mechanisms involving the secretion of Type I interferons by plasmacytoid dendritic cells (pDC), the recruitment of basophils to lymph nodes, and the activation of adaptive immune responses through B and T cells...
February 2017: Autoimmunity
https://www.readbyqxmd.com/read/28165193/polysaccharides-l900-2-and-l900-3-isolated-from-lactobacillus-rhamnosus-lock-0900-modulate-allergic-sensitization-to-ovalbumin-in-a-mouse-model
#15
Sabina Górska, Martin Schwarzer, Dagmar Srutkova, Petra Hermanova, Ewa Brzozowska, Hana Kozakova, Andrzej Gamian
Here, we compared the abilities of polysaccharides L900/2 and L900/3, which were previously isolated from Lactobacillus rhamnosus LOCK 0900, to modulate the immune response to bystander antigens in a mouse model of ovalbumin (OVA) sensitization. In vivo, both polysaccharides reduced the levels of OVA-specific IgE, IgE-dependent basophil degranulation and IgG2a antibodies, but had no effect on the levels of OVA-specific IgA or IgG1. Interestingly, both polysaccharides triggered recall cellular responses with distinct properties...
February 6, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28165149/post-metamorphic-development-of-skin-glands-in-a-true-toad-parotoids-versus-dorsal-skin
#16
Eleonora Regueira, Camila Dávila, Alina G Sassone, María E Ailín O'Donohoe, Gladys N Hermida
Chemical defenses in amphibians are a common antipredatory and antimicrobial strategy related to the presence of dermal glands that synthesize and store toxic or unpalatable substances. Glands are either distributed throughout the skin or aggregated in multiglandular structures, being the parotoids the most ubiquitous macrogland in toads of Bufonidae. Even though dermal glands begin to develop during late-larval stages, many species, including Rhinella arenarum, have immature glands by the end of metamorphosis, and their post-metamorphic growth is unknown...
February 6, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28163193/the-neuropathological-signature-of-bulbar-onset-als-a-systematic-review
#17
REVIEW
S Shellikeri, V Karthikeyan, R Martino, S E Black, L Zinman, J Keith, Y Yunusova
ALS is a multisystem disorder affecting cognitive and motor functions. Bulbar-onset ALS (bALS) may be preferentially associated with language/cognitive impairments, compared with spinal-onset ALS (sALS), stemming from a potentially unique neuropathology. The objective of this systematic review was to compare neuropathology reported for bALS and sALS subtypes in studies of cadaveric brains. Using Cochrane guidelines, we reviewed articles in MEDLINE, Embase, and PsycINFO databases using standardized search terms for ALS and neuropathology, from inception until July 16th 2016...
February 2, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28160513/the-clinical-and-immunological-effects-of-pru-p-3-slit-on-peach-and-peanut-allergy-in-patients-with-systemic-reactions
#18
F Gomez, G Bogas, M Gonzalez, P Campo, M Salas, A Diaz-Perales, M J Rodriguez, A Prieto, D Barber, M Blanca, M J Torres, C Mayorga
BACKGROUND: The peach non-specific lipid transfer protein (nsLTP), Pru p 3, is the primary sensitizer in fruits and responsible for severe reactions in the Mediterranean area. Peach allergy is frequently associated with other allergies such as peanut. Therefore, it is important to assess how specific immunotherapy to Pru p 3 could affect both peach and peanut tolerance. OBJECTIVES: To evaluate peach and peanut desensitization and immunological changes after one year of Pru p 3 sublingual immunotherapy (SLIT) in patients with systemic allergic reactions to peach and/or peanut...
February 4, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28160012/first-in-human-studies-of-seletalisib-an-orally-bioavailable-small-molecule-pi3k%C3%AE-inhibitor-for-the-treatment-of-immune-and-inflammatory-diseases
#19
Eric Helmer, Mark Watling, Emma Jones, Dominique Tytgat, Mark Jones, Rodger Allen, Andrew Payne, Annelize Koch, Eugene Healy
PURPOSE: PI3Ks are potential therapeutic targets in immune-inflammatory diseases. These studies aimed to investigate the safety, tolerability and PK profile of seletalisib, a selective inhibitor of PI3Kδ in humans. METHODS: These phase I, randomised, double-blind, placebo-controlled, single-centre studies (NCT02303509, NCT02207595) evaluated single and multiple oral doses of seletalisib (5-90 mg QD and 30 mg BID) in healthy adults and subjects with mild-to-moderate psoriasis (Study-1)...
February 4, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28154998/upregulated-expression-of-substance-p-sp-and-nk1r-in-eczema-and-sp-induced-mast-cell-accumulation
#20
Mengmeng Zhan, Wenjiao Zheng, Qijun Jiang, Zuotao Zhao, Zhiyun Wang, Junling Wang, Huiyun Zhang, Shaoheng He
Substance P (SP) was reported to be associated with eczema and acts as a potent skin mast cell secretagogue. However, little is known of its expression in inflammatory cells in eczema and its ability in induction of mast cell accumulation. In the present study, we investigated expression of SP and neurokinin-1 receptor (NK1R) on peripheral blood leukocytes and mast cells from patients with eczema and influence of SP on mast cell accumulation by using flow cytometry analysis, trans-epithelial cell migration assay and mouse peritoneal model...
February 2, 2017: Cell Biology and Toxicology
keyword
keyword
19942
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"