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Carcinoma gallbladder

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https://www.readbyqxmd.com/read/28925490/multi-detector-spiral-ct-diagnosis-of-common-bile-duct-ampullary-carcinoma
#1
D-Z Zhao, Y Guo, Y-P Sun, H-M Liu, Z Zhang, Q-L Ma, Y-S Wang, C-L Chen
OBJECTIVE: The aim of this project was to study the imaging characteristics of multi-detector CT (MDCT) in different types of malignant tumor in the common bile duct ampulla. PATIENTS AND METHODS: We examined 30 cases of pancreatic head cancer, 35 of terminal cholangiocarcinoma, 26 of ampullary carcinoma, and 40 of benign lesions, all confirmed by pathology. We used 64-slice spiral CT plain scan and multi-phase enhanced scan with multi-planar reconstruction (MPR) and curved planar reconstruction (CPR) post-processing to obtain three-dimensional images...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28914998/clinicopathological-characteristics-of-distant-metastases-of-adenocarcinoma-squamous-cell-carcinoma-and-urothelial-carcinoma-an-autopsy-study-of-older-japanese-patients
#2
Yoko Matsuda, Atsuko Seki, Keisuke Nonaka, Mototsune Kakizaki, Tan Wang, Junko Aida, Naoshi Ishikawa, Yuta Nakano, Daita Kaneda, Tadayuki Takata, Junko Takahashi-Fujigasaki, Shigeo Murayama, Kaiyo Takubo, Toshiyuki Ishiwata, Motoji Sawabe, Tomio Arai
AIM: We aimed to clarify the characteristics of malignancies in older adults focusing on distant metastasis in the whole body. METHODS: We retrospectively evaluated 7710 cases of autopsies (4011 men, 3699 women, median age of 80 years), and analyzed the characteristics of metastasis of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma in each organ. RESULTS: The total number of cases with adenocarcinoma, squamous cell carcinoma or urothelial carcinoma was 2856, and most of them were adenocarcinomas...
September 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28912249/preoperative-staging-of-cholangiocarcinoma-and-biliary-carcinoma-using-18f-fluorodeoxyglucose-positron-emission-tomography-a-meta-analysis
#3
Jing-Hong Hu, Jui-Hsiang Tang, Cheng-Hui Lin, Yin-Yi Chu, Nai-Jen Liu
This meta-analysis was performed to determine the diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in assessing primary cholangiocarcinoma (CCA) and CCA with lymph node and distant metastasis. A literature search for studies reporting the use of 18F-FDG-PET for preoperative work-up/staging in patients with CCA was performed. Diagnostic OR (DOR) was used as an index of diagnostic performance of FDG-PET/CT in predicting primary CCA, lymph node metastases, and distant metastases...
September 14, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28905807/buttressing-hepaticojejunostomy-apos-s-with-hepatic-round-ligament-flap-may-be-beneficial
#4
Jayant Kumar Banerjee, Ramanathan Saranga Bharathi, Pankaj Purushotam Rao
BACKGROUND: Bile leaks and anastomotic strictures are important complications of hepaticojejunostomy (HJ). Evidence suggests that the use of hepatic round ligament (HRL) to buttress HJ may be beneficial. This study evaluates the feasibility of this approach. METHODS: HJs performed over 2 years (Jun 2014- May 2016), with HRL reinforcement, were analyzed. Operative outcomes measured included technical difficulty, blood loss, time necessary for flap harvest, and reinforcement of HJ...
August 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28900988/-analysis-of-primary-site-and-pathology-on-903-patients-with-neuroendocrine-neoplasms
#5
Xudong Qiu, Meng Liu, Qing Liu, Zhiying Yang, Jixi Liu, Fanqiang Meng, Zaiyong Wang, Yanfen Shi, Liguo Liu, Pan Zhang, Jie Luo, Huangying Tan
OBJECTIVE: To explore the primary site and pathological feature of neuroendocrine neoplasm (NEN), especially the NEN of digestive system. METHODS: Clinicopathological data of NEN patients at China-Japan Friendship Hospital from January 2012 to December 2016 were retrospectively analyzed. Tumor primary sites were summarized. Association between tumor site and pathological grading in gastroenteropancreatic neuroendocrine neoplasm(GEP-NEN) was examined. RESULTS: There were a total of 903 cases of NEN...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28892903/immunohistochemical-study-of-muc1-and-muc5ac-expression-in-gall-bladder-lesions
#6
Amit Bhoge, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Bageshri Gogate, Maithili Mandar Kulkarni, Pallavi Bhayekar
INTRODUCTION: Immunohistochemical (IHC) markers of mucin family are associated with various Gallbladder Lesions (GBLs). AIM: To study the distribution of GBL with respect to age and sex as well as to analyse the IHC profile of MUC1 and MUC5AC in GBLs and attempt correlation with clinical and histopathological findings. MATERIALS AND METHODS: The present study was conducted over a period of six years. A technique of manual tissue array was employed for cases subjected to IHC using MUC1 and MUC5AC...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890824/gemcitabine-and-capecitabine-for-advanced-biliary-cancer
#7
Emmanuel Gabriel, Shipra Gandhi, Kristopher Attwood, Boris Kuvshinoff, Steven Hochwald, Renuka Iyer
BACKGROUND: Gemcitabine with capecitabine (gem-cap) is an established regimen for advanced biliary cancer (ABC) supported by our previously reported phase II trial. Here, we provide our updated experience. METHODS: Single institution, retrospective study from 2005 to 2015 of ABC treated with gem-cap. RESULTS: A total of 372 patients with ABC were identified, of whom 227 (61.0%) were treated with chemotherapy. 153 patients (67.4%) received gem-cap, of which 129 (56...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890312/clinicopathological-features-and-prognosis-of-advanced-biliary-carcinoma-centered-in-the-cystic-duct
#8
Yoshitsugu Nakanishi, Takahiro Tsuchikawa, Keisuke Okamura, Toru Nakamura, Takehiro Noji, Toshimichi Asano, Kimitaka Tanaka, Toshiaki Shichinohe, Tomoko Mitsuhashi, Satoshi Hirano
BACKGROUND: Whether to classify "advanced (subserosal layer or greater invasion)" biliary carcinoma centered in the cystic duct (BCCD) as gallbladder carcinoma (GBC) or perihilar cholangiocarcinoma (PHCC) remains unclear. METHODS: The clinicopathological features and overall survival (OS) of patients with advanced BCCD were examined through a comparison with those of patients with advanced PHCC and with GBC. RESULTS: 290 patients were classified as 199 PHCC, 44 GBC, and 47 BCCD...
September 7, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28864456/history-of-comorbidities-and-survival-of-ovarian-cancer-patients-results-from-the-ovarian-cancer-association-consortium
#9
Albina N Minlikeeva, Jo L Freudenheim, Kevin H Eng, Rikki A Cannioto, Grace Friel, J Brian Szender, Brahm Segal, Kunle Odunsi, Paul Mayor, Brenda Diergaarde, Emese Zsiros, Linda E Kelemen, Martin Köbel, Helen Steed, Anna deFazio, Susan J Jordan, Peter A Fasching, Matthias W Beckmann, Harvey A Risch, Mary Anne Rossing, Jennifer A Doherty, Jenny Chang-Claude, Marc T Goodman, Thilo Dörk, Robert Edwards, Francesmary Modugno, Roberta B Ness, Keitaro Matsuo, Mika Mizuno, Beth Y Karlan, Ellen L Goode, Susanne K Kjær, Estrid Høgdall, Joellen M Schildkraut, Kathryn L Terry, Daniel W Cramer, Elisa V Bandera, Lisa E Paddock, Lambertus A Kiemeney, Leon F A G Massuger, Rebecca Sutphen, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Celeste L Pearce, Anna H Wu, Jolanta Kupryjanczyk, Allan Jensen, Penelope M Webb, Kirsten B Moysich
Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients.Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival...
September 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28798003/neuroendocrine-carcinoma-of-gall-bladder-a-rare-presentation-with-review-of-literature
#10
Amit Gupta, Parvez Ahmed, Prashant Durgapal, Pooja Kala, Shalinee Rao, Rajesh Pasricha, Sanjeev Misra
Neuroendocrine tumors are the rarest tumors of gallbladder. The most aggressive variant is neuroendocrine carcinoma which presents in about 0.5% of all gallbladder carcinomas and 0.2% of all neuroendocrine tumors. It seems possible that survival rates can be improved by utilizing wide surgical resection combined with chemotherapy. We report a case of neuroendocrine carcinoma of gall bladder in a 20-year old female patient. In present case, the etiology was not known as patient did not have cholelithiasis or any symptoms related to chronic inflammation...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28795384/contribution-of-hepatobiliary-scintigraphy-in-assessing-alpps-most-suited-timing
#11
Stéphanie Truant, Clio Baillet, Anne Claire Deshorgue, Mehdi El Amrani, Damien Huglo, François-René Pruvot
To reduce post-hepatectomy liver failure (PHLF), associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been recently developed for patients with a limited future remnant liver (FRL). Nevertheless, high morbi-mortality rates have been reported . The current study aimed to analyze the kinetics of FRL function in patients who were offered ALPPS. Serial SPECT (99 m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) was performed in all patients before and after surgery as well as at inter-stage to quantitatively assess hepatic function [total liver (TL) and FRL]...
August 9, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28767800/prevalence-of-gallbladder-cancer-in-patients-submitted-to-cholecystectomy-experience-of-the-university-hospital-faculty-of-medical-sciences-state-university-of-campinas-unicamp
#12
Márcio Apodaca-Rueda, Everton Cazzo, Rita Barbosa De-Carvalho, Elinton Adami Chaim
Objective: to evaluate the prevalence of gallbladder carcinoma in patients submitted to cholecystectomy for chronic cholecystitis at the University Hospital of the State University of Campinas. Methods: we conducted a retrospective prevalence study through the analysis of histological specimens from January 2010 to May 2015. Results: we analyzed 893 patient reports. Emergency cholecystectomies amounted to 144, and elective ones, 749 (16.2% and 83...
May 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28750922/elevation-of-ca19-9-and-cea-is-associated-with-a-poor-prognosis-in-patients-with-resectable-gallbladder-carcinoma
#13
Zhijian Wen, Anfeng Si, Jue Yang, Pinghua Yang, Xinwei Yang, Hu Liu, Xingzhou Yan, Wengang Li, Baohua Zhang
AIMS: The aim of this study was to determine whether a combination of the tumour markers carcinoembryonic (CEA) and carbohydrate antigen 19-9 (CA19-9) would be helpful in predicting the prognosis of patients with gallbladder carcinoma (GBC) who underwent resection. METHODS: A retrospective analysis of clinico-pathological features and survival of 390 patients with GBC who were treated between January 2003 and December 2013. Time-dependent receiver operating characteristic (ROC) was used to evaluate the prognostic ability of tumour markers...
July 24, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28749000/-bone-metastases-of-a-gallbladder-carcinoma-detected-by-positron-emission-tomography-computed-tomography-case-report
#14
Pamela Humeres, Patricio González, Javiera González, Elizabeth Prado, Enrique Hiplan
Signet ring gallbladder carcinoma is a rare aggressive variant of mucinous adenocarcinoma with poor prognosis. Positron emission tomography/computed tomography (PET/CT) with Fluor18 deoxyglucose (F18-FDG) is a useful tool in the staging of gallbladder cancer. We report a 68 years old man with a surgically resected acute cholecystitis, whose biopsy was positive for signet ring cell gallbladder carcinoma. During surgery, locoregional lymph nodes, liver or peritoneal involvement were not detected. A PET/CT was performed for staging, finding multiple hypermetabolic lytic bone lesions...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28747272/efficacy-and-safety-of-radiofrequency-ablation-for-focal-hepatic-lesions-adjacent-to-gallbladder-reconfiguration-of-the-ablation-zone-through-probe-relocation-and-ablation-time-reduction
#15
In Young Choi, Pyo Nyun Kim, Sung Gu Lee, Hyung Jin Won, Yong Moon Shin
PURPOSE: To evaluate the safety and efficacy of radiofrequency (RF) ablation for treatment of focal hepatic lesions adjacent to the gallbladder with electrode relocation and ablation time reduction. MATERIALS AND METHODS: Thirty-nine patients who underwent RF ablation for focal hepatic lesions adjacent to the gallbladder (≤ 10 mm) were evaluated retrospectively from January 2011 to December 2014 (30 men and 9 women; age range, 51-85 y; mean age, 65 y). Of 36 patients with hepatocellular carcinoma, 3 had a second treatment for recurrence (mean tumor size, 15 mm ± 6)...
July 23, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28736626/molecular-landscape-and-sub-classification-of-gastrointestinal-cancers-a-review-of-literature
#16
REVIEW
Bita Fakhri, Kian-Huat Lim
The historical approach of diagnosing cancer types based entirely on anatomic origin and histologic features, and the "one-size-fit-all" therapeutic approach, are inadequate in modern cancer treatment. From decades of research we now know that cancer is a highly heterogeneous disease driven by complex genetic or epigenetic alterations. The advent of various high throughput molecular tools has now enabled us to view and sub-classify each cancer type based on their distinct molecular features, in addition to histologic classification, with the promise of individualized treatment strategies tailored towards each specific subtype to improve patient outcomes...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28731994/-the-frequency-and-clinical-profile-of-gallbladder-cancer-in-patients-undergoing-cholecystectomy-in-3-reference-hospitals-in-chiclayo-between-2011-2015
#17
Fernando Eulogio Peña Dávila, Fernando Andrés Sánchez Renteria, Jorge Fernandez Mogollon, Martha Roxana Rodríguez Rodríguez
OBJECTIVES: To describe the frequency and clinical profile of gallbladder cancer in patients undergoing cholecystectomy in 3 reference hospitals in Chiclayo between 2011-2015. MATERIALS AND METHODS: A retrospective cross-sectional study. The study is divided into 2 phases, the first was to count the total number of reports of gallbladder pathology and select positive cases for cancer; the second phase was to collect data from the medical records of patients positive for cancer...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28731820/uncommon-neoplasms-of-the-biliary-tract-radiological-findings
#18
Vincenza Granata, Roberta Fusco, Orlando Catalano, Salvatore Filice, Antonio Avallone, Mauro Piccirillo, Maddalena Leongito, Raffaele Palaia, Roberto Grassi, Francesco Izzo, Antonella Petrillo
OBJECTIVES: To report our cancer center experience in the biliary tumors incidence other than cholangiocellular-carcinoma (CCC), emphasizing the radiological features. METHODS: 197 patients with biliary disease undergoing Gd-EOB-DTPA-enhanced MRI were reviewed. Four radiologists evaluated retrospectively size, structure, anatomical site, and signal intensity of lesions on MRI. Enhancement-pattern during the arterial-, portal-, and late-phase on US, CT and MR study was assessed as well as the enhancement pattern during the hepatobiliary-phase on MRI...
July 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28731197/metastatic-gallbladder-carcinoma-in-meningioma-a-case-report
#19
Burak Eren, Feyza Karagoz Guzey, Ilker Gulec, Azmi Tufan
Metastases from tumors to systemic cancers are rare. The most common intracranial recipient tumor is meningioma. Metastasis from gallbladder cancer has been previously reported from only one patient during autopsy. We present the case of a 72-year-old woman who underwent surgery for right frontal skull base meningioma.The tumor was completely removed. Histological specimens showed gallbladder carcinomatous metastasis with diffuse neuroendocrine differentiation in meningothelial meningioma. The Ki-67 proliferation index of the meningioma was 3%...
June 2, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28729631/therapeutic-effects-of-long-circulating-mir-135a-containing-cationic-immunoliposomes-against-gallbladder-carcinoma
#20
Guanghua Yang, Baobing Yin
Gallbladder carcinoma (GBC) is the most common malignant tumour in the biliary tract, but effective therapeutics are lacking. Based on our previous studies, miR-135a is a potential tool to inhibit GBC proliferation. In this study, we constructed miR-135a-loaded DSPE-PEG2000 liposomes modified with Anti-EGFR antibodies (Anti-EGFR-CIL-miR-135a). The results of an analysis of their physicochemical properties indicated the particle size of it was 222.0 ± 2.1 nm in diameter with an uptake efficiency of 86...
July 20, 2017: Scientific Reports
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