Shusheng Wang, Yan Zhao, Zhicheng Yang, Yujun Liu, Ru Xu, Ruoxin Tu, Songping Liu, Xin Zou, Lan Zhang, Jie Hao, Pengfei Gao
Postpartum depression (PPD) has a significant impact on the physical and mental health of mothers, potentially leading to symptoms such as low mood, fatigue, and decreased appetite. It may also affect the healthy growth of the infant. The onset of PPD is closely related to abnormalities in inflammation and the immune system. PPD patients exhibit abnormalities in the proportion of peripheral blood immune cells, along with an increase in pro-inflammatory cytokines. Excessive pro-inflammatory cytokines in peripheral blood can disrupt the blood-brain barrier (BBB) by activating astrocytes and reducing transendothelial electrical resistance (TEER), allowing peripheral immune cells or cytokines to enter the brain and trigger inflammation, ultimately leading to the onset of depression...
April 20, 2024: Biomedicine & Pharmacotherapy