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Muscle fatigue

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https://www.readbyqxmd.com/read/28441760/supplementation-with-a-polyphenol-rich-extract-perfload-%C3%A2-improves-physical-performance-during-high-intensity-exercise-a-randomized-double-blind-crossover-trial
#1
Julien Cases, Cindy Romain, Cristian Marín-Pagán, Linda H Chung, José Miguel Rubio-Pérez, Caroline Laurent, Sylvie Gaillet, Emmanuelle Prost-Camus, Michel Prost, Pedro E Alcaraz
Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food supplement, PerfLoad(®), was able to improve metabolic homeostasis and physical performance during high-intensity exercises under anaerobic conditions. The effect of a supplementation has been investigated on fifteen recreationally-active male athletes during a randomized, double-blind and crossover clinical investigation...
April 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28441375/primary-adrenal-angiosarcoma-a-rare-and-potentially-misdiagnosed-tumor
#2
Ariel Grajales-Cruz, Francis Baco-Viera, Ernesto Rive-Mora, Carlos Ramirez-Tanchez, David Tasso, Norma Arroyo-Portela, Elizabeth Calderon, Ilean Joan Padua-Octaviani, William Caceres-Perkins
A man aged 69 years presented with acute right flank pain secondary to a hemorrhagic large adrenal tumor. En bloc resection was performed to repair the inferior vena cava. Immunoperoxidase levels in the tumor were positive for factor VIII and CD31 and negative for S100, protein Melan-A, CD34, synaptophysin, chromogranin, desmin, muscle specific actin, ETFA (EMA), KRT20 (CK20), CDX2, TTF1, LNPEP (PLAP), inhibin, ?-fetoprotein, CD30, hepatocyte paraffin, and aberrant expression of cytokeratin 7 and pankeratin...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28438761/improved-skeletal-muscle-ca-2-regulation-in-vivo-following-contractions-in-mice-overexpressing-pgc-1%C3%AE
#3
Hiroaki Eshima, Shinji Miura, Nanami Senoo, Koji Hatakeyama, David C Poole, Yutaka Kano
In skeletal muscle, resting intracellular Ca(2+) concentration ([Ca(2+)]i) homeostasis is exquisitely regulated by Ca(2+) transport across the sarcolemmal, mitochondrial and sarcoplasmic reticulum (SR) membranes. Of these three systems, the relative importance of the mitochondria in [Ca(2+)]i regulation remains poorly understood in in vivo skeletal muscle. We tested the hypothesis that the capacity for Ca(2+) uptake by mitochondria is a primary factor in determining [Ca(2+)]i regulation in muscle at rest and following contractions...
April 24, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28436534/a-novel-trpa1-variant-is-associated-with-carbamazepine-responsive-cramp-fasciculation-syndrome
#4
M J Nirenberg, R Chaouni, T M Biller, R M Gilbert, C Paisán-Ruiz
Cramp-fasciculation syndrome (CFS) is a rare muscle hyperexcitability syndrome that presents with muscle cramps, fasciculations, and stiffness, as well as pain, fatigue, anxiety, hyperreflexia, and paresthesias. Although familial cases have been reported, a genetic etiology has not yet been identified. We performed whole-exome sequencing followed by validation and cosegregation analyses on a father-son pair with CFS. Both subjects manifested other hypersensitivity-hyperexcitability symptoms, including asthma, gastroesophageal reflux, migraine, restless legs syndrome, tremor, cold hyperalgesia, and cardiac conduction defects...
April 24, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28433474/beneficial-effect-of-tocilizumab-in-myasthenia-gravis-refractory-to-rituximab
#5
Dagur Ingi Jonsson, Ritva Pirskanen, Fredrik Piehl
Muscle fatigue associated with myasthenia gravis is caused by autoantibodies interfering with neuromuscular transmission. Immunomodulating treatment is widely used in moderate to severe myasthenia, although the use of newer biological drugs except rituximab is rare. We describe the effect of tocilizumab, a blocker of interleukin-6 signalling, in two female myasthenia patients with high titres of serum acetylcholine receptor antibodies and insufficient response to rituximab. The first patient had been treated with high dose immunoglobulins regularly for several years and the second patient had been treated both with different oral immune suppressants and immunoglobulins before testing a low dose of rituximab without significant clinical effect...
March 16, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28432118/molecular-basis-for-exercise-induced-fatigue-the-importance-of-strictly-controlled-cellular-ca-2-handling
#6
Arthur J Cheng, Nicolas Place, Håkan Westerblad
The contractile function of skeletal muscle declines during intense or prolonged physical exercise, that is, fatigue develops. Skeletal muscle fibers fatigue acutely during highly intense exercise when they have to rely on anaerobic metabolism. Early stages of fatigue involve impaired myofibrillar function, whereas decreased Ca(2+) release from the sarcoplasmic reticulum (SR) becomes more important in later stages. SR Ca(2+) release can also become reduced with more prolonged, lower intensity exercise, and it is then related to glycogen depletion...
April 21, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28431150/the-natural-history-of-children-with-joint-hypermobility-syndrome-and-ehlers-danlos-hypermobility-type-a-longitudinal-cohort-study
#7
Mark C Scheper, Lesley L Nicholson, Roger D Adams, Louise Tofts, Verity Pacey
Objectives.: The objective of the manuscript was to describe the natural history of complaints and disability in children diagnosed with joint hypermobility syndrome (JHS)/Ehlers-Danlos-hypermobility type (EDS-HT) and to identify the constructs that underlie functional decline. Methods.: One hundred and one JHS/EDS-HT children were observed over 3 years and assessed at three time points on the following: functional impairments, quality of life, connective tissue laxity, muscle function, postural control and musculoskeletal and multi-systemic complaints...
April 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28429147/docetaxel-related-fatigue-in-men-with-metastatic-prostate-cancer-a-descriptive-analysis
#8
A R T Bergin, E Hovey, A Lloyd, G Marx, P Parente, T Rapke, P de Souza
PURPOSE: Fatigue is a prevalent and debilitating side effect of docetaxel chemotherapy in metastatic prostate cancer. A better understanding of the kinetics and nature of docetaxel-related fatigue may provide a framework for intervention. METHODS: This secondary analysis was performed using the MOTIF database, from a phase III, randomised, double-blind, placebo-controlled study of modafinil (200 mg/day for 15 days) for docetaxel-related fatigue in men with metastatic prostate cancer [1]...
April 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28426509/log-transformed-emg-amplitude-power-output-relationship-single-leg-knee-extensor-versus-single-leg-cycle-ergometry
#9
Eric B Noble, Joshua M Pilarski, Harshal K Vora, Jorge M Zuniga, Moh H Malek
Comparing and contrasting motor unit recruitment and activation for the same muscles for multiple versus single-joint exercise may provide a better understanding of neuromuscular fatigue. The purpose of this study, therefore, is to compare the slope and y-intercept terms for the three superficial quadriceps femoris (vastus lateralis, rectus femoris, and vastus medialis) muscles derived from the log-transformed EMG amplitude-power output relationship between the single-leg knee-extensor ergometry and the single-leg cycle ergometry...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28422523/can-the-lamberts-submaximal-cycle-test-reflect-overreaching-in-professional-cyclists
#10
Lieselot Decroix, Robert P Lamberts, Romain Meeusen
PURPOSE: The Lamberts and Lambert Submaximal Cycle Test (LSCT) consists of 3 stages during which cyclist's cycle for 6 minutes at 60%, 6 minutes at 80% and 3 minutes at 90% of their maximal heart rate, followed by one-minute recovery. It was the aim of this study to determine if the LSCT is able to reflect a state of functional overreaching in professional female cyclists during an 8-day training camp and the following recovery days. METHODS: Six professional female cyclists performed an LSCT on day 1, day 5 and day 8 of the training camp and 3 days after the training camp...
April 19, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28422520/low-level-laser-therapy-improves-performance-and-reduces-fatigue-in-competitive-cyclists
#11
Fábio J Lanferdini, Rodrigo R Bini, Bruno M Baroni, Kelli D Klein, Felipe P Carpes, Marco A Vaz
Evidence supports that low-level laser therapy (LLLT) minimizes fatigue effects on muscle performance. However, the ideal LLLT dosage to improve athletes' performance during sports activities, such as cycling, is still unclear. Therefore, the goal of this study was to investigate the effects of different LLLT dosages on cyclists' performance in time-to-exhaustion tests. In addition, we looked at the effects of LLLT on the frequency content of the EMG signals to assess fatigue mechanisms. Twenty male competitive cyclists participated in a crossover, randomized, double-blind and placebo-controlled trial...
April 19, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28420353/the-influence-of-fatigue-and-chronic-low-back-pain-on-muscle-recruitment-patterns-following-an-unexpected-external-perturbation
#12
Júlia Jubany, Lieven Danneels, Rosa Angulo-Barroso
BACKGROUND: Chronic low back pain (CLBP) has been associated with altered trunk muscle responses as well as increased muscle fatigability. CLBP patients and fatigued healthy subjects could experience similar neuromuscular strategies to attempt to protect the spine. The current study examined muscle activation differences between healthy and CLBP subjects following a perturbation. In addition, the possible role of muscle fatigue was evaluated by investigating the healthy control subjects in a non-fatigued and a fatigued condition...
April 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28419751/clinical-characteristics-of-fibromyalgia-in-a-chronic-pain-population
#13
Mark Gostine, Fred Davis, Bradley Roberts, Rebecca Risko, Michael Asmus, Joseph C Cappelleri, Alesia Sadosky
OBJECTIVE: To compare fibromyalgia (FM) characteristics among patients identified in a community-based chronic pain cohort based on traditional International Classification of Diagnoses Ninth Revision, ICD-9 diagnostic coding, with that of patients identified using a novel predictive model. METHODS: This retrospective study used data collected from July 1999 to February 17, 2015 in multiple chronic pain clinics in the United States. Patients were assigned to the FM case group based on specific inclusion criteria using ICD-9 codes or, separately, from results of a novel FM predictive model that was developed using random forest and logistic regression techniques...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28418751/influence-of-exergaming-on-the-perception-of-cancer-related-fatigue
#14
Ricardo da Silva Alves, Denise Hollanda Iunes, Isabela Carvalho Pereira, Juliana Bassalobre Carvalho Borges, Denismar Alves Nogueira, Andreia Maria Silva, Daniel Ferreira Moreira Lobato, Leonardo Cesar Carvalho
OBJECTIVE: Exercise is recommended for cancer patients to reduce fatigue and improve quality of life. This study's aim is to evaluate the influence of an exergaming protocol on cancer-related fatigue, muscle fatigue, and muscle strength in cancer patients. MATERIALS AND METHODS: We conducted a quasi-experimental control study using exergaming in all groups through an Xbox360 Kinect™ console, two to three times per week, for 20 sessions. Three groups were created: cancer patients in chemotherapy and/or radiotherapy group (CRG; n:15), cancer patients after chemotherapy and/or radiotherapy (CAG; n:15), and a control group (CG; n:15)...
April 2017: Games for Health
https://www.readbyqxmd.com/read/28415067/effect-of-whey-protein-in-conjunction-with-a-caloric-restricted-diet-and-resistance-training
#15
Wesley D Dudgeon, Elizabeth P Kelley, Timothy P Scheett
Dudgeon, WD, Kelley, EP, and Scheett, TP. Effect of whey protein in conjunction with a caloric-restricted diet and resistance training. J Strength Cond Res 31(5): 1353-1361, 2017-Caloric-restricted weight loss, especially rapid weight loss, results from a decrease in both lean and fat mass (FM). The goal for many is to lose FM while retaining lean body mass (LBM) and muscular performance thus many turn to supplements. Sixteen resistance-trained men (24 ± 1.6 years of age) completed a 4 d·wk body building style split resistance training program for 8 weeks in conjunction with a pre-exercise, periexercise, and postexercise ingestion of whey protein (WHEY) nutritional supplement or carbohydrate (CON)-based nutritional supplement...
May 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28414608/mechanobehavioral-scores-in-women-with-and-without-tmj-disc-displacement
#16
L R Iwasaki, Y M Gonzalez, Y Liu, H Liu, M Markova, L M Gallo, J C Nickel
Cartilage fatigue may be a factor in the precocious development of degenerative changes in the temporomandibular joint (TMJ). This cross-sectional study estimated potential for cartilage fatigue via TMJ energy densities (ED) and jaw muscle duty factors (DF), which were combined to calculate mechanobehavioral scores (MBS) in women with (+) and without (-) bilateral TMJ disc displacement (DD). All subjects gave informed consent to participate and were examined using Diagnostic Criteria (DC) for Temporomandibular Disorders (TMD) and magnetic resonance (MR) and computed tomography (CT) images...
April 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28413944/the-assessment-of-motor-fatigability-in-persons-with-multiple-sclerosis-a-systematic-review
#17
Deborah Severijns, Inge Zijdewind, Ulrik Dalgas, Ilse Lamers, Caroline Lismont, Peter Feys
BACKGROUND: Persons with multiple sclerosis (PwMS) are often characterized by increased motor fatigability, which is a performance change on an objectively measured criterion after any type of voluntary muscle contractions. This review summarizes the existing literature to determine which protocols and outcome measures are best to detect or study motor fatigability and the underlying mechanisms in MS. METHODS: Two electronic databases, PubMed and Web of Science, were searched for relevant articles published until August 2016 with a combination of multiple sclerosis, fatigability, muscle fatigue, and motor fatigue...
May 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28410831/feasibility-and-efficacy-of-presurgical-exercise-in-survivors-of-rectal-cancer-scheduled-to-receive-curative-resection
#18
Favil Singh, Robert U Newton, Michael K Baker, Nigel A Spry, Dennis R Taaffe, Daniel A Galvão
BACKGROUND: Localized rectal carcinoma is invasive, with surgical resection the standard treatment. The aim of this study was to determine the feasibility of a supervised presurgical exercise intervention in patients with rectal cancer prior to rectal resection. PATIENTS AND METHODS: Twelve patients volunteered to undertake twice-weekly aerobic and resistance exercise for ∼16 weeks prior to surgery. At baseline, presurgery, and ∼8 weeks postsurgery, muscle strength and physical performance, body composition, quality of life, and fatigue were assessed...
March 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28409515/effects-of-stretching-and-fatigue-on-peak-torque-muscle-imbalance-and-stability
#19
Pablo B Costa, Cassio V Ruas, Cory M Smith
BACKGROUND: The present study examined the acute effects of hamstrings stretching and fatigue on knee extension and flexion peak torque (PT), hamstrings to quadriceps (H:Q) ratio, and postural stability. METHODS: Seventeen women (mean ± SD age = 21.8 ± 2.1 yrs; body mass = 63.0 ± 10.5 kg; height = 164.7 ± 6.2 cm) and eighteen men (25.8 ± 4.6 yrs; 83.6 ± 13.2 kg; 175.3 ± 6.0 cm) took part in three laboratory visits. The first visit was a familiarization session, and the subsequent two visits were randomly assigned as a control or stretching condition...
April 13, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28409508/performance-of-muscle-strength-and-fatigue-tolerance-in-young-trained-women-supplemented-with-caffeine
#20
Carlos A Fett, Natalia Magalhães Aquino, Jairo Schantz, Camila F Brandão, Joás D de Araújo Cavalcanti, Waleria C Rezende Fett
BACKGROUND: Verify the effect of caffeine supplementation on the muscular strength and fatigue tolerance of young trained women. METHODS: Eight women of 25±5 years old, who had undergone a minimum of 12 months of continuous resisted training, body mass index 20-23 kg/m2 were submitted to four tests: one repetition maximum (1- RM, kg) to pull down (PD), hack squat (HS), bench press (BP), and; knee extension exhaustion (drop-set, 100/80/60 kg, repetitions) (DS). They perform the tests in four consecutive blocks one-week apart crossover system: basal without caffeine (B); first caffeine (C1); placebo with starch supplementation (P); second caffeine (C2)...
April 13, 2017: Journal of Sports Medicine and Physical Fitness
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