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Muscle fatigue

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https://www.readbyqxmd.com/read/28093857/can-blood-flow-restriction-augment-muscle-activation-during-high-load-training
#1
Scott J Dankel, Samuel L Buckner, Matthew B Jessee, Kevin T Mattocks, J Grant Mouser, Brittany R Counts, Gilberto C Laurentino, Jeremy P Loenneke
INTRODUCTION: Blood flow restriction has been shown to augment muscle activation and increase muscle size when combined with low-load training; however, much less is known on whether blood flow restriction can augment muscle activation during high-load exercise. PURPOSE: To determine whether applying blood flow restriction can augment muscle activation with traditional high-load resistance exercise. METHOD: Ten individuals completed two sets of elbow flexion exercise to volitional fatigue...
January 16, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28093429/paediatric-ed-bipap-continuous-quality-improvement-programme-with-patient-analysis-2005-2013
#2
Thomas Abramo, Abby Williams, Samaiya Mushtaq, Mark Meredith, Rawle Sepaule, Kristen Crossman, Cheryl Burney Jones, Suzanne Godbold, Zhuopei Hu, Todd Nick
OBJECTIVE: In paediatric moderate-to-severe asthmatics, there is significant bronchospasm, airway obstruction, air trapping causing severe hyperinflation with more positive intraplural pressure preventing passive air movement. These effects cause an increased respiratory rate (RR), less airflow and shortened inspiratory breath time. In certain asthmatics, aerosols are ineffective due to their inadequate ventilation. Bilevel positive airway pressure (BiPAP) in acute paediatric asthmatics can be an effective treatment...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28093034/fear-of-cancer-recurrence-and-unmet-needs-among-breast-cancer-survivors-in-the-first-five-years-a-cross-sectional-study
#3
Mai-Britt Bjørklund Ellegaard, Cai Grau, Robert Zachariae, Anders Bonde Jensen
BACKGROUND: It is unclear to which degree the services available after end of treatment are sufficient to meet the needs of women treated for breast cancer. The aim of the present study was to identify patient-reported supportive care needs and the prevalence of fear of cancer recurrence (FCR) following end of treatment in women treated for breast cancer. MATERIAL AND METHODS: Using a cross-sectional design, women treated for breast cancer (n = 155; mean age 63) completed questionnaires concerning supportive care needs and FCR...
January 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28090140/influence-of-warm-up-duration-and-recovery-interval-prior-to-exercise-on-anaerobic-performance
#4
M Frikha, N Chaâri, N Mezghanni, N Souissi
The purpose of the study was to determine the impact of different active warm-up (AWU) durations and the rest interval separating it from exercise on anaerobic performance. Eleven male physical education students (22.6 ± 2.52 years; 179.2 ± 4.3 cm; 82.5 ± 9.7 kg; mean ± SD) participated in a cross-over randomized study, and they all underwent the Wingate test after three AWU durations: 5 min (AWU5), 15 min (AWU15) and 20 min (AWU20), with recovery (WREC) or without a recovery interval (NREC) separating the AWU and anaerobic exercise performance...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28086894/c60-fullerene-as-promising-therapeutic-agent-for-correcting-and-preventing-skeletal-muscle-fatigue
#5
Yurij I Prylutskyy, Inna V Vereshchaka, Andriy V Maznychenko, Nataliya V Bulgakova, Olga O Gonchar, Olena A Kyzyma, Uwe Ritter, Peter Scharff, Tomasz Tomiak, Dmytro M Nozdrenko, Iryna V Mishchenko, Alexander I Kostyukov
BACKGROUND: Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats. RESULTS: During fatigue development, we observed decrease in the muscle effort level before C60FAS administration...
January 13, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28078668/mitochondrial-adaptations-to-exercise-in-human-skeletal-muscle-a-possible-role-for-cristae-density-as-a-determinant-of-muscle-fitness
#6
Christopher G R Perry
Skeletal muscle possesses a remarkable plasticity in response to repeated exercise challenges (i.e. exercise 'training'). A hallmark phenotypic change is an increase in the ability to sustain contraction and resist fatigue. Such increased muscle endurance is linked, in part, to an improved ability to sustain ATP synthesis aerobically through coordinated enhancements in the delivery of oxygen (e.g. cardiorespiratory, vascular adaptations) and its utilization within skeletal muscle mitochondria for the oxidation of fat and carbohydrates...
January 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28078451/slower-but-not-faster-unilateral-fatiguing-knee-extensions-alter-contralateral-limb-performance-without-impairment-of-maximal-torque-output
#7
Olaf Prieske, Saied J Aboodarda, José A Benitez Sierra, David G Behm, Urs Granacher
PURPOSE: The purpose of the present study was to examine the effects of unilateral fatigue of the knee extensors at different movement velocities on neuromuscular performance in the fatigued and non-fatigued leg. METHODS: Unilateral fatigue of the knee extensors was induced in 11 healthy young men (23.7 ± 3.8 years) at slower (60°/s; FAT60) and faster movement velocities (240°/s; FAT240) using an isokinetic dynamometer. A resting control (CON) condition was included...
January 11, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28075248/evaluation-of-vibrant-muscles-over-shoulder-region-among-workers-of-the-hand-screen-printing-industry
#8
Subramaniam Shankar, Raju Naveenkumar, Jeganathan Karthick, Periyasamy Mohankumar
This study focuses on the evaluation of the muscle activities associated with shoulder pain among workers of the hand screen printing (HSP) industry. Activities of three major muscles which showed higher muscle activity for a HSP job were observed for fatigue using surface electromyography (SEMG). The anatomical sites were chosen on the basis of a statistical survey and visual inspection conducted before the experiment. Activities of the deltoid, teres major and infraspinatus were recorded using SEMG and the nature of muscle activities was studied for about 50 m of cloth printing...
January 11, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28073840/fda-approval-summary-sonidegib-for-locally-advanced-basal-cell-carcinoma
#9
Denise Casey, Suzanne Demko, Stacy Shord, Hong Zhao, Huanyu Chen, Kun He, Alexander Putman, Whitney S Helms, Patricia Keegan, Richard Pazdur
On July 24, 2015, the U. S. Food and Drug Administration (FDA) approved sonidegib (ODOMZO®, Novartis) for treatment of patients with locally advanced basal cell carcinoma (laBCC) not amenable to curative surgery or radiation therapy. The approval was based on data from one randomized, double-blind, non-comparative trial of two doses of sonidegib administered to 230 hedgehog inhibitor-naïve patients with metastatic basal cell carcinoma (mBCC, n=36) or laBCC (n=194). Patients were randomized 2:1 to receive sonidegib 800 mg (n=151) or 200 mg (n=79) daily...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28069951/calsequestrin-depolymerizes-when-calcium-is-depleted-in-the-sarcoplasmic-reticulum-of-working-muscle
#10
Carlo Manno, Lourdes C Figueroa, Dirk Gillespie, Robert Fitts, ChulHee Kang, Clara Franzini-Armstrong, Eduardo Rios
Calsequestrin, the only known protein with cyclical storage and supply of calcium as main role, is proposed to have other functions, which remain unproven. Voluntary movement and the heart beat require this calcium flow to be massive and fast. How does calsequestrin do it? To bind large amounts of calcium in vitro, calsequestrin must polymerize and then depolymerize to release it. Does this rule apply inside the sarcoplasmic reticulum (SR) of a working cell? We answered using fluorescently tagged calsequestrin expressed in muscles of mice...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28067943/gamma-aminobutyric-acid-gaba-modulators-for-amyotrophic-lateral-sclerosis-motor-neuron-disease
#11
REVIEW
Andrea Diana, Rita Pillai, Paolo Bongioanni, Aidan G O'Keeffe, Robert G Miller, Dan H Moore
BACKGROUND: Imbalance of gamma aminobutyric acid (GABA) and related modulators has been implicated as an important factor in the pathogenesis of amyotrophic lateral sclerosis (ALS), which is also known as motor neuron disease (MND). In this context, the role and mechanism of action of gabapentin and baclofen have been extensively investigated, although with conflicting results. This is the first systematic review to assess clinical trials of GABA modulators for the treatment of ALS. OBJECTIVES: To examine the efficacy of gabapentin, baclofen, or other GABA modulators in delaying the progression of ALS, and to evaluate adverse effects of these interventions...
January 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28064025/plantar-flexor-muscle-weakness-and-fatigue-in-spastic-cerebral-palsy-patients
#12
Daria Neyroud, Stéphane Armand, Geraldo De Coulon, Sarah R Dias Da Silva, Nicola A Maffiuletti, Bengt Kayser, Nicolas Place
BACKGROUND: Patients with cerebral palsy develop an important muscle weakness which might affect the aetiology and extent of exercise-induced neuromuscular fatigue. AIM: This study evaluated the aetiology and extent of plantar flexor neuromuscular fatigue in patients with cerebral palsy. METHODS: Ten patients with cerebral palsy and 10 age- and sex-matched healthy individuals (∼20 years old, 6 females) performed four 30-s maximal isometric plantar flexions interspaced by a resting period of 2-3s to elicit a resting twitch...
January 5, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28063860/could-objective-tests-be-used-to-measure-fatigue-in-patients-with-advanced-cancer
#13
Gustavo Schvartsman, Minjeong Park, Diane D Liu, Sriram Yennu, Eduardo Bruera, David Hui
CONTEXT: Assessment of cancer-related fatigue is currently based on patient-reported outcomes. We asked whether objective assessments such as muscle strength and nutritional markers can be used as surrogate measures of cancer-related fatigue. OBJECTIVE: We examined the association among three fatigue scales, muscle strength, and nutritional markers in patients with advanced cancer. METHODS: In this prospective study, we enrolled hospitalized cancer patients who had been seen in palliative care consultation at MD Anderson Cancer Center...
January 4, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28062608/a-61-year-old-woman-with-muscle-fatigue-and-increased-cardiac-troponin
#14
William A Parsonage, Jane E Mikli, Janelle C Nisbet, Christian Hamilton-Craig, George A Marshall
No abstract text is available yet for this article.
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28060035/etiology-and-recovery-of-neuromuscular-fatigue-following-simulated-soccer-match-play
#15
Kevin Thomas, Jack Dent, Glyn Howatson, Stuart Goodall
PURPOSE: We profiled the etiology and recovery of neuromuscular fatigue post-simulated-soccer-match-play. METHODS: Fifteen semi-professional players completed a 90 min simulated soccer match. Pre-, immediately-post and at 24, 48 and 72 h participants completed a battery of neuromuscular, physical and perceptual tests. Perceived fatigue and muscle soreness were assessed via visual analogue scales. Maximum voluntary contraction (MVC) and twitch responses to electrical (femoral nerve) and magnetic (motor cortex) stimulation during isometric knee-extensor contractions and at rest were measured to assess central (voluntary activation, VA) and peripheral (quadriceps potentiated twitch force, Qtw,pot) fatigue, and responses to single and paired-magnetic stimuli were assessed to quantify corticospinal excitability and short-intracortical inhibition (SICI), respectively...
January 3, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28057014/cocktail-treatment-with-egfr-specific-and-cd133-specific-chimeric-antigen-receptor-modified-t-cells-in-a-patient-with-advanced-cholangiocarcinoma
#16
Kai-Chao Feng, Ye-Lei Guo, Yang Liu, Han-Ren Dai, Yao Wang, Hai-Yan Lv, Jian-Hua Huang, Qing-Ming Yang, Wei-Dong Han
BACKGROUND: Cholangiocarcinoma (CCA) is one of the most fatal malignant tumors with increasing incidence, mortality, and insensitivity to traditional chemo-radiotherapy and targeted therapy. Chimeric antigen receptor-modified T cell (CART) immunotherapy represents a novel strategy for the management of many malignancies. However, the potential of CART therapy in treating advanced unresectable/metastatic CCA is uncharted so far. CASE PRESENTATION: In this case, a 52-year-old female who was diagnosed as advanced unresectable/metastatic CCA and resistant to the following chemotherapy and radiotherapy was treated with CART cocktail immunotherapy, which was composed of successive infusions of CART cells targeting epidermal growth factor receptor (EGFR) and CD133, respectively...
January 5, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28054362/the-6-minute-mastication-test-a-unique-test-to-assess-endurance-of-continuous-chewing-normal-values-reliability-reproducibility-and-usability-in-patients-with-mitochondrial-disease
#17
Lenie van den Engel-Hoek, Simone Knuijt, Marjo van Gerven, Marloes Lagarde, Jan T Groothuis, Imelda J M de Groot, Mirian C H Janssen
In patients with mitochondrial disease, fatigue and muscle problems are the most common complaints. They also experience these complaints during mastication. To measure endurance in continuous mastication in patients with mitochondrial diseases the 6-minute mastication test (6MMT) was developed. This study included the collection of normal data for the 6MMT in a healthy population (children and adults). During 6 minutes of continuous mastication on a chew tube chewing cycles per minute, total amount of chewing cycles and the difference between minute 1 (M1 ) and minute 6 (M2 ) were collected in 271 healthy participants (5 - 80 years old)...
January 5, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28054274/nicorandil-improves-post-fatigue-tension-in-slow-skeletal-muscle-fibers-by-modulating-glutathione-redox-state
#18
E Sánchez-Duarte, X Trujillo, C Cortés-Rojo, A Saavedra-Molina, G Camargo, L Hernández, M Huerta, R Montoya-Pérez
Fatigue is a phenomenon in which force reduction has been linked to impairment of several biochemical processes. In skeletal muscle, the ATP-sensitive potassium channels (KATP) are actively involved in myoprotection against metabolic stress. They are present in sarcolemma and mitochondria (mitoKATP channels). K(+) channel openers like nicorandil has been recognized for their ability to protect skeletal muscle from ischemia-reperfusion injury, however, the effects of nicorandil on fatigue in slow skeletal muscle fibers has not been explored, being the aim of this study...
January 4, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28054262/does-photobiomodulation-therapy-is-better-than-cryotherapy-in-muscle-recovery-after-a-high-intensity-exercise-a-randomized-double-blind-placebo-controlled-clinical-trial
#19
Thiago De Marchi, Vinicius Mazzochi Schmitt, Guilherme Pinheiro Machado, Juliane Souza de Sene, Camila Dallavechia de Col, Olga Tairova, Mirian Salvador, Ernesto Cesar Pinto Leal-Junior
This study aimed to determine the effectiveness of photobiomodulation therapy (PBMT) and cryotherapy, in isolated and combined forms, as muscle recovery techniques after muscle fatigue-inducing protocol. Forty volunteers were randomly divided into five groups: a placebo group (PG); a PBMT group (PBMT); a cryotherapy group (CG); a cryotherapy-PBMT group (CPG); and a PBMT-cryotherapy group (PCG). All subjects performed four sessions at 24-h intervals, during which they submitted to isometric assessment (MVC) and blood collection in the pre-exercise period, and 5 and 60 min post-exercise, while the muscle fatigue induction protocol occurred after the pre-exercise collections...
January 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28050921/influence-of-dietary-acid-load-on-exercise-performance
#20
Catherine Applegate, Mackenzie Mueller, Krystle E Zuniga
Diet composition can affect systemic pH and acid-base regulation, which may in turn influence exercise performance. An acidic environment in the muscle impairs performance and contributes to fatigue; therefore, current trends in sports nutrition place importance on maximizing the alkalinity of the body with ergogenic aids and dietary strategies. This review examines the evidence on the effects of dietary manipulations on acid load and exercise performance. Ten studies that investigated the effect of high versus low dietary acid loads on athletic performance generally identified that low dietary acid loads increased plasma pH, but did not consistently improve exercise performance at maximal or submaximal exercise intensities...
January 4, 2017: International Journal of Sport Nutrition and Exercise Metabolism
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