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https://www.readbyqxmd.com/read/28632300/chemo-bacterial-synthesis-of-a-sialyl-tn-cyclopeptide-vaccine-candidate
#1
Emeline Richard, C Pifferi, M Fiore, Eric Samain, Audrey Le Gouellec, Sébastien Fort, Olivier Renaudet, Bernard Priem
A conjugatable form of the tumour-associated carbohydrate antigen sialyl-Tn (Neu5Ac-alfa-2,6-GalNAc) was efficiently produced in Escherichia coli. Metabolically engineered E. coli strains overexpressing the 6-sialyl-transferase gene of Photobacterium sp. and CMP-Neu5Ac synthetase genes of Neisseria meningitidis were cultivated at high density in presence of GalNAc-alfa-propargyl as the exogeneous acceptor. The target disaccharides, which were produced on the scale of several hundred milligrams, were then conjugated using CuAAC click chemistry to a fully synthetic and immunogenic scaffold with the aim to create a candidate anticancer vaccine...
June 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28604375/retained-upper-third-molars-during-le-fort-i-osteotomy-with-downfracture
#2
Marco Friscia, Marzia Petrocelli, Carolina Sbordone, Raffaele Corvino, Fabio Maglitto, Francesco Maria Cassandro, Giorgio Iaconetta, Luigi Califano
AIM: The aim of our study is to demonstrate that the presence of upper wisdom teeth must be evaluated before and during Le Fort I osteotomy because attention must be focused to the disadvantages or facilitations of surgery depending on molar presence. MATERIALS OF STUDY: Our study has analyzed two groups, each one including 20 patients, 10 males and 10 females, with an age between 16-30 years. The first group was treated with le Fort I osteotomy leaving in situ the wisdom upper third molars...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28601432/stability-and-surgical-complications-in-segmental-le-fort-i-osteotomy-a-systematic-review
#3
REVIEW
O L Haas Junior, R Guijarro-Martínez, A P de Sousa Gil, L da Silva Meirelles, R B de Oliveira, F Hernández-Alfaro
This systematic review was conducted to evaluate the stability and surgical complications of segmental Le Fort I osteotomy. The search was divided into a main search (PubMed, Embase, and Cochrane Library), grey literature search (Google Scholar), and manual search. Twenty-three studies were included: 14 evaluating stability as the outcome and nine evaluating surgical complications. The level of agreement between the authors was considered excellent (κ=0.893 for study selection and κ=0.853 for study eligibility)...
June 7, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28599124/three-dimensional-reconstruction-of-post-traumatic-deficient-anterior-maxilla
#4
Adi Rachmiel, Dekel Shilo, Dror Aizenbud, Mark Pen, Dana Rachmiel, Omri Emodi
PURPOSE: Maxillary retrognathism appears in 14.3% of patients exhibiting malocclusion after trauma treatment. This report describes the application of alveolar distraction osteogenesis (ADO) for treating the severely deficient anterior maxilla after trauma injuries in the vertical and anteroposterior planes. MATERIALS AND METHODS: This is a retrospective study of patients exhibiting severe vertical and anteroposterior maxillary bone deficiency after trauma injuries and treated by ADO as a first stage with additional Le Fort I advancement when required...
May 15, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28598184/surface-electromyography-before-and-after-orthognathic-surgery-and-condylectomy-in-active-laterognathia-a-case-report
#5
F Cullati, A Mapelli, G Beltramini, M Codari, C L Pimenta Ferreira, A Baj, A B Giannì, C Sforza
BACKGROUND: Condylar hyperplasia is a rare bone disease characterised by excessive development of mandibular condyle, which can lead to the development of asymmetric facial deformity together with malocclusion, mandibular deviation, TMJ and masticatory musculoskeletal system dysfunction. There is not a treatment protocol universally accepted. In order to determine the correct management, treatment and intervention timing of these patients, morphological examinations should be coupled with functional assessments...
June 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28570459/alar-pinning-in-rigid-external-distraction-for-midfacial-hypoplasia
#6
Jenny L Yu, Albert S Woo
BACKGROUND: Distraction osteogenesis with a rigid external distractor is a widely accepted treatment for midfacial hypoplasia. In this study, the authors introduce the utilization of alar pinning with the external halo distractor for maxillary advancement, in place of an oral splint. METHODS: A retrospective chart review was conducted of 7 patients who successfully underwent distraction osteogenesis using the alar pinning technique. Midfacial hypoplasia was secondary to Crouzon syndrome (n = 4), Apert syndrome (n = 1), Pfeiffer syndrome (n = 1), or bacterial meningitis (n = 1)...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28570410/nasal-soft-tissue-change-following-bimaxillary-orthognathic-surgery
#7
Hye-In Jeong, Ho-Sung Lee, Young-Soo Jung, Hyung-Sik Park, Hwi-Dong Jung
OBJECTIVE: The purpose of this study is to identify the correlation between maxillary movement and nasal soft tissue changes on three-dimensional reconstructed cone beam computed tomography (CBCT) images after Le Fort I osteotomy. MATERIALS AND METHODS: The authors also investigate the long-term change of alar base width (ABW) to determine the effect of cinch suture. The authors retrospectively studied 52 subjects (14 males and 38 females) who were treated by bimaxillary orthognathic surgery including Le Fort I osteotomy and mandibular ramus surgery...
May 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28562535/the-structural-changes-of-upper-airway-and-newly-developed-sleep-breathing-disorders-after-surgical-treatment-in-class-iii-malocclusion-subjects
#8
Ui Lyong Lee, Hoon Oh, Sang Ki Min, Ji Ho Shin, Yong Seok Kang, Won Wook Lee, Young Eun Han, Young Jun Choi, Hyun Jik Kim
Bimaxillary surgery is the traditional treatment of choice for correcting class III malocclusion which is reported to cause an alteration of oropharyngeal structures and upper airway narrowing that might be a predisposing factor for obstructive sleep apnea (OSA). This study aimed to analyze sleep parameters in class III malocclusion subjects and ascertain the prevalence of snoring or OSA following bimaxillary surgery.A total of 22 patients with Le Fort I osteotomy and mandibular setback for class III malocclusion were prospectively enrolled...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538077/monobloc-frontofacial-or-le-fort-iii-distraction-osteogenesis-in-syndromic-craniosynostosis-three-dimensional-evaluation-of-treatment-outcome-and-the-need-for-central-distraction
#9
Ching-Hsuan Hu, Chieh-Tsai Wu, Ellen Wen-Ching Ko, Philip Kuo-Ting Chen
BACKGROUND: The objectives of this study were to investigate the treatment effect, morphology, and volumetric outcomes of monobloc frontofacial or Le Fort III distraction osteogenesis in syndromic craniosynostosis by 3-dimensional evaluation. MATERIALS AND METHODS: Nine consecutive patients underwent monobloc frontofacial or Le Fort III distraction during 2003 to 2012 were included and evaluated. The patient's evaluation is a minimum of a 4-year follow-up. Pretreatment, post-treatment advancement, and relapse were quantified...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28528359/anatomic-basis-of-le-fort-1-impaction-osteotomy-a-radiological-study
#10
Rivka Bendrihem, Christian Vacher, Audrey Fohlen, Jean-Pierre Pelage
PURPOSE: In Le Fort 1 osteotomy when a maxillary impaction is necessary, surgeons have to face different anatomical problems. (1) To determine the best bone resection route, they have to consider the situation of dental roots, infraorbital foramen and maxillary artery. (2) In case of Le Fort 1 osteotomy combined with a mandibular sagittal split osteotomy, the palate has to be replaced in horizontal position although there is no anatomical landmark. (3) In case of Gummy smiles, it can be due to either long face or short upper lip...
May 20, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28515028/augmentation-of-the-infraorbital-rim-in-orthognathic-surgery
#11
T Fattahi, S Salman, B Steinberg
Mid-face augmentation via a Le Fort I osteotomy is a commonly performed operation. Advancement of the upper jaw and associated structures (nose, lower cheek areas) can certainly improve function as well as facial aesthetics and harmony. Often, in patients with severe mid-face deficiency, hypoplasia of the maxilla extends all the way up to the infraorbital rims. The receding infraorbital rim contributes to the negative vector of the globes. In patients with this level of mid-face hypoplasia, while advancing the maxilla at the Le Fort I level satisfies all of the requirements for orthognathic surgery, the deficient infraorbital rim remains unchanged and can actually accentuate the negative vector of the globes...
May 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28499507/nasolabial-changes-after-two-different-approaches-for-surgically-assisted-rapid-maxillary-expansion
#12
N Alves, T F M Oliveira, V A Pereira-Filho, E S Gonçales, M A C Gabrielli, L A Passeri
This retrospective study evaluated the nasolabial changes in patients who underwent surgically assisted rapid maxillary expansion (SARME) using two different approaches. Nineteen patients were included in the study, divided into two groups according to the kind of surgical approach performed: group 1 (n=9), SARME performed through the standard Le Fort I circumvestibular approach followed by the alar base cinch, and group 2 (n=10), SARME performed through a subtotal vestibular approach associated to a V-shaped incision at the maxillary midline in the labial frenulum region, without alar base cinch...
May 9, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28493922/comparison-of-the-long-term-clinical-performance-of-a-biodegradable-and-a-titanium-fixation-system-in-maxillofacial-surgery-a-multicenter-randomized-controlled-trial
#13
B Gareb, N B van Bakelen, G J Buijs, J Jansma, J G A M de Visscher, Th J M Hoppenreijs, J E Bergsma, B van Minnen, B Stegenga, R R M Bos
BACKGROUND: Biodegradable fixation systems could reduce or eliminate problems associated with titanium removal of implants in a second operation. AIM: The aim of this study was to compare the long-term (i.e. >5 years postoperatively) clinical performance of a titanium and a biodegradable system in oral and maxillofacial surgery. MATERIALS AND METHODS: The present multicenter Randomized Controlled Trial (RCT) was performed in four hospitals in the Netherlands...
2017: PloS One
https://www.readbyqxmd.com/read/28489659/relationship-between-the-quantity-of-nerve-exposure-during-bilateral-sagittal-split-osteotomy-surgery-and-sensitive-recovery
#14
Paolo Gennaro, Maria Elisa Giovannoni, Niccolò Pini, Ikenna Valentine Aboh, Guido Gabriele, Giorgio Iannetti, Flavia Cascino
AIM AND OBJECTIVES: The purpose of this study was to evaluate how different exposures of the V3 nerves during orthognathic surgery impact neurosensory disturbances. METHODS: The study included 127 patients who underwent either bilateral sagittal split osteotomy (BSSO) or BSSO with maxillary le Fort 1. They were divided into 6 groups, identified by the quantity of V3 nerve exposure. All patients were examined in a pre-op period and again after 1, 3, 6 months post-op...
May 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28488465/surgical-management-of-lower-limb-fractures-in-patients-with-spinal-cord-injury-less-associated-with-complications-than-non-operative-management-a-retrospective-series-of-cases
#15
Alban Fouasson-Chailloux, Raphael Gross, Marc Dauty, Guillaume Gadbled, Sophie Touchais, Marc Le Fort, Brigitte Perrouin-Verbe
OBJECTIVES: To evaluate the difference in terms of overall complications between surgical and non-surgical management of lower limb fractures in patients with chronic spinal cord injury (SCI). DESIGN: A 13-year retrospective study including patients with chronic spinal cord lesion admitted for sublesional lower limb fractures. SETTING: University hospital SCI reference departments (Rehabilitation department and orthopedic department). PARTICIPANTS: Forty patients with SCI were included, 24 men and 16 women...
May 10, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28468158/velopharyngeal-insufficiency-after-le-fort-i-osteotomy-in-a-patient-with-undiagnosed-occult-submucous-cleft-palate
#16
Rushil R Dang, Bonnie L Padwa, Cory M Resnick
The authors present a 16-year-old patient with no known history of cleft palate who developed velopharyngeal insufficiency after a Le Fort I osteotomy performed for the correction of maxillary hypoplasia and a Class III malocclusion. Postoperative evaluation revealed the presence of velopharyngeal insufficiency and subtle findings of an occult submucous cleft palate. She had a pharyngeal flap 6 months later with successful correction of the velopharyngeal insufficiency. This case illustrates the need to screen for submucous cleft palate prior to orthognathic surgery...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28466191/operative-time-blood-loss-hemoglobin-drop-blood-transfusion-and-hospital-stay-in-orthognathic-surgery
#17
Ra'ed Ghaleb Salma, Fahad Mohammed Al-Shammari, Bishi Abdullah Al-Garni, Mohammed Abdullah Al-Qarzaee
PURPOSE: This study was conducted to evaluate the operative time, blood loss, hemoglobin drop, blood transfusion, and length of hospital stay in orthognathic surgery. METHODS: A 10-year retrospective analysis was performed on patients who underwent bilateral sagittal split osteotomy (with or without genioplasty), Le Fort I osteotomy (with or without genioplasty), or any combination of these procedures. A total of 271 patients were included. RESULTS: The age range was 17 to 49 years, with a mean age of 24...
June 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28463990/the-presence-of-bacterial-microcolonies-on-the-maxillary-sinus-ciliary-epithelium-in-healthy-young-individuals
#18
Monika Morawska-Kochman, Krzysztof Marycz, Katarzyna Jermakow, Kamil Nelke, Wojciech Pawlak, Marek Bochnia
OBJECTIVE: The aim of this cross-sectional in vitro study was to evaluate the mucosal surfaces of healthy maxillary sinuses, explore different forms of bacterial microorganism colonies present on the mucous membrane, and determine a mucosal surface area they occupy. METHODS: Samples of the maxillary sinus mucosa were collected from 30 healthy patients (M = 11; F = 19). The material was obtained during the Le Fort I osteotomy performed during corrective jaw surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28462475/use-positional-screws-for-le-fort-i-osteotomy-fixation-technical-note
#19
Rafael Linard Avelar, Maykel Sullyvan Marinho de Souza, Eduardo Costa Studart Soares, Rodrygo Nunes Tavares
In recent years, several studies related to fixation systems have been published, but few suggest any variations of the Le Fort I osteotomy technique, and the use of plates and screws placed along the canine and zygomatic pillar are common. The 20-year-old patient with Crouzon syndrome presented with severe hypoplasia of the maxillary, mandibular prognathism, and class III facial pattern. The patient underwent orthognathic surgery and high Le Fort I osteotomy with the fixation of eight positional screws. The aim of this paper is to describe a different technique for the fixation in high maxillary osteotomies, which can be used in specific cases...
May 1, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28462182/evaluation-of-temporomandibular-disorders-before-and-after-orthognathic-surgery-therapeutic-considerations-on-a-sample-of-76-patients
#20
Carlo di Paolo, Giorgio Pompa, Paolo Arangio, Anna di Nunno, Stefano Di Carlo, Daniele Rosella, Piero Papi, Piero Cascone
OBJECTIVES: Temporomandibular disorders may be associated with dental and facial malformations. The aim of this study is to record the prevalence of TMDs in patients scheduled for orthognathic surgery, reporting the development of TMDs and symptoms during the entire period of the treatment, and demonstrating the benefits of a team effort on this population. MATERIALS AND METHODS: Assessment of temporomandibular status was performed using the RDC/TMD criteria at T0 (prior to orthodontic therapy), T1 (3 months after the surgery), and T2 post-therapeutic cycle (6 to 12 months postoperatively)...
March 2017: Journal of International Society of Preventive & Community Dentistry
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