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Skeletal muscle

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https://www.readbyqxmd.com/read/29156747/lethality-of-inappropriate-plasma-exposure-on-chicken-embryonic-development
#1
Jiao Jiao Zhang, Jin Oh Jo, Do Luong Huynh, Mrinmoy Ghosh, Nameun Kim, Sang Baek Lee, Hak Kyo Lee, Young Sun Mok, Taeho Kwon, Dong Kee Jeong
In this study, we examined the effects of non-thermal dielectric barrier discharge plasma on embryonic development in chicken eggs in order to determine the optimal level of plasma exposure for the promotion of embryonic growth. We exposed developing chicken embryos at either Hamburger-Hamilton (HH) stage 04 or HH 20 to plasma at voltages of 11.7 kV to 27.6 kV. Our results show exposure at 11.7 kV for 1 min promoted chicken embryonic development, but exposure to more duration and intensity of plasma resulted in dose-dependent embryonic death and HH 20 stage embryos survive longer than those at stage HH 04...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156739/electroacupuncture-alleviates-neuromuscular-dysfunction-in-an-experimental-rat-model-of-immobilization
#2
Jun Yang, Su Min, Fei Xie, Jingyuan Chen, Xuechao Hao, Li Ren
Immobilization-related skeletal muscle atrophy is a major concern to patients in Intensive Care Units and it has a profound effect on the quality of life. However, the underlying molecular events for the therapeutic effect of electroacupuncture to treat muscle atrophy have not been fully elucidated. Here we developed an immobilization mouse model and tested the hypothesis that skeletal muscle weakness may be caused by the increased expression of γ and α7 nicotinic acetylcholine receptors (nAChRs) on muscle cell membranes, while electroacupuncture could decrease the expression of γ and α7 nicotinic acetylcholine receptors...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156133/harnessing-sphingosine-1-phosphate-signaling-and-nanotopographical-cues-to-regulate-skeletal-muscle-maturation-and-vascularization
#3
Jonathan Hung Tsui, Kajohnkiart Janebodin, Nicholas Ieronimakis, David Michael Patrick Yama, Hee Seok Yang, Rakchanok Chavanachat, Aislinn L Hays, Haeshin Lee, Morayma Reyes, Deok-Ho Kim
Despite possessing substantial regenerative capacity, skeletal muscle can suffer from loss of function due to catastrophic traumatic injury or degenerative disease. In such cases, engineered tissue grafts hold the potential to restore function and improve patient quality of life. Requirements for successful integration of engineered tissue grafts with the host musculature include cell alignment that mimics host tissue architecture and directional functionality, as well as vascularization to ensure tissue survival...
November 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29155999/high-incomplete-skeletal-muscle-fatty-acid-oxidation-explains-low-muscle-insulin-sensitivity-in-poorly-controlled-t2d
#4
Timothy P Gavin, Jacob M Ernst, Hyo-Bum Kwak, Sarah E Caudill, Melissa A Reed, Ron T Garner, Yaohui Nie, Jessica A Weiss, Walter J Pories, Moahad Dar, Chien-Te Lin, Monica J Hubal, P Darrell Neufer, Shihuan Kuang, G Lynis Dohm
Aim: We investigated if skeletal muscle insulin sensitivity was different between well (WCD) and poorly (PCD) controlled T2D and if the difference was associated with differences due to mitochondrial respiratory function. Methods: Vastus lateralis muscle mitochondrial respiration, mitochondrial content, mitochondrial enzyme activity, and fatty acid oxidation (FAO) were measured. Insulin sensitivity (SI) and the acute response to glucose (AIRg) were calculated by MINMOD analysis from glucose and insulin obtained during a modified, frequently sampled, intravenous glucose tolerance test...
November 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29155791/improved-protocol-for-chromatin-immunoprecipitation-from-mouse-skeletal-muscle
#5
Shilpy Joshi, Vanessa Ueberschlag-Pitiot, Daniel Metzger, Irwin Davidson
We describe an efficient and reproducible protocol for the preparation of chromatin from adult mouse skeletal muscle, a physically resistant tissue with a high content of structural proteins. Dissected limb muscles from adult mice are physically disrupted by mechanical homogenisation, or a combination of mincing and douncing, in a hypotonic buffer before formaldehyde fixation of the cell lysate. The fixed nuclei are purified by further cycles of mechanical homogenisation or douncing and sequential filtrations to remove cell debris...
November 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155716/evaluation-of-injury-induced-senescence-and-in-vivo-reprogramming-in-the-skeletal-muscle
#6
Coralie Cazin, Aurelie Chiche, Han Li
Cellular senescence is a stress response that is characterized by a stable cellular growth arrest, which is important for many physiological and pathological processes, such as cancer and ageing. Recently, senescence has also been implicated in tissue repair and regeneration. Therefore, it has become increasingly critical to identify senescent cells in vivo. Senescence-associated β-galactosidase (SA-β-Gal) assay is the most widely used assay to detect senescent cells both in culture and in vivo. This assay is based on the increased lysosomal contents in the senescent cells, which allows the histochemical detection of lysosomal β-galactosidase activity at suboptimum pH (6 or 5...
October 26, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29154824/skeletal-muscle-development-on-the-30th-anniversary-of-myod
#7
EDITORIAL
Michael Taylor
No abstract text is available yet for this article.
November 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29154822/mef2-and-the-skeletal-muscle-differentiation-program
#8
REVIEW
Michael V Taylor, Simon M Hughes
Mef2 is a conserved and significant transcription factor in the control of muscle gene expression. In cell culture Mef2 synergises with MyoD-family members in the activation of gene expression and in the conversion of fibroblasts into myoblasts. Amongst its in vivo roles, Mef2 is required for both Drosophila muscle development and mammalian muscle regeneration. Mef2 has functions in other cell-types too, but this review focuses on skeletal muscle and surveys key findings on Mef2 from its discovery, shortly after that of MyoD, up to the present day...
November 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29154420/relationship-between-skeletal-muscle-mass-and-cardiac-function-during-exercise-in-community-dwelling-older-adults
#9
Masamitsu Sugie, Kazumasa Harada, Tetsuya Takahashi, Marina Nara, Joji Ishikawa, Teruyuki Koyama, Hunkyung Kim, Jun Tanaka, Hajime Fujimoto, Shuichi Obuchi, Stephan von Haehling, Syunei Kyo, Hideki Ito
AIMS: This study aimed to investigate the relationship between skeletal muscle mass and cardiac functional parameters in older adults during cardiopulmonary exercise testing (CPET). METHODS AND RESULTS: Sixty-three Japanese community-dwelling older adults were enrolled (20 men and 43 women; mean age 80 years, range 65-97 years). Cardiac functional parameters during exercise were assessed using CPET. Skeletal muscle mass index (SMI) was calculated by dividing the appendicular lean mass (measured using dual-energy X-ray absorptiometry) by height in metres squared...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29154261/electrical-impedance-of-the-torso-is-associated-with-the-pressure-pain-threshold-on-myofascial-trigger-points-in-patients-with-chronic-neck-pain-a-cross-sectional-study
#10
Almir Vieira Dibai-Filho, Marília Artese Barros, Alessandra Kelly de Oliveira, Rinaldo Roberto de Jesus Guirro
BACKGROUND: Myofascial trigger points are dysfunctional structures present in skeletal muscles and are related to sensory, motor, and autonomic changes. Despite scientific advances in recent decades in the measurement of musculoskeletal pain, evaluation of this clinical phenomenon is supported with instruments that, although valid and reliable, have a considerable degree of subjectivity. OBJECTIVE: To correlate electrical impedance of the upper limbs and torso with pain intensity, functional capacity, catastrophizing, pressure pain threshold, and skin temperature on myofascial trigger points in the upper trapezius muscle of patients with neck pain...
November 10, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29154162/epigenetic-reprogramming-in-metabolic-disorders-nutritional-factors-and-beyond
#11
REVIEW
Zhiyong Cheng, Louise Zheng, Fabio A Almeida
Environmental factors (e.g., malnutrition and physical inactivity) contribute largely to metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and nonalcoholic fatty liver diseases. The abnormalities in metabolic activity and pathways have been increasingly associated with altered DNA methylation, histone modification and noncoding RNAs, whereas lifestyle interventions targeting diet and physical activity can reverse the epigenetic and metabolic changes. Here we review recent evidence primarily from human studies that links DNA methylation reprogramming to metabolic derangements or improvements, with a focus on cross-tissue (e...
October 23, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29153940/tumor-derived-cytokines-impair-myogenesis-and-alter-the-skeletal-muscle-immune-microenvironment
#12
Kelly A Hogan, Dong Seong Cho, Paige C Arneson, Adrienne Samani, Patrick Palines, Yanan Yang, Jason D Doles
Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging, obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not only reduces quality of life, but also directly impacts cancer mortality, chemotherapeutic efficacy, and surgical outcomes. There is an incomplete understanding of the role of tumor-derived factors in muscle wasting and sparse knowledge of how these factors impact in vivo muscle regeneration. Here, we identify several cytokines/chemokines that negatively impact in vitro myogenic differentiation...
November 16, 2017: Cytokine
https://www.readbyqxmd.com/read/29153363/uterine-fibroids-influence-of-t2-rim-sign-on-immediate-therapeutic-responses-to-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-ablation
#13
Sin Yuin Yeo, Young-Sun Kim, Hyo Keun Lim, Hyunchul Rhim, Sin-Ho Jung, Na Young Hwang
OBJECTIVES: To investigate the influence of a high-signal-intensity peripheral rim on T2-weighted MR images (i.e., T2-rim sign) on the immediate therapeutic responses of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids. METHODS: This retrospective study was approved by the institutional review board, and patient informed consent was obtained for MR-HIFU ablation. In total, 196 fibroids (diameter 6.2±2.6cm) in 123 women (age 43...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29152896/trimetazidine-restores-the-positive-adaptation-to-exercise-training-by-mitigating-statin-induced-skeletal-muscle-injury
#14
Ming Song, Fang-Fang Chen, Yi-Hui Li, Lei Zhang, Feng Wang, Ran-Ran Qin, Zhi-Hao Wang, Ming Zhong, Meng-Xiong Tang, Wei Zhang, Lu Han
BACKGROUND: Exercise rehabilitation is demonstrated to improve the prognosis of patients with coronary heart disease (CHD). Statins, as the key medicine to lower cholesterol in CHD, result in skeletal muscle injury and impair exercise training adaptation. Energy metabolism dysfunction is identified as the potential mechanism underlying statin-induced skeletal muscle injury. In this study, we investigated the effects of the metabolic modulator trimetazidine on skeletal muscle energy metabolism and statin-associated exercise intolerance...
November 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29152538/isolation-of-primary-human-skeletal-muscle-cells
#15
Janelle M Spinazzola, Emanuela Gussoni
Primary myoblast culture is a valuable tool in research of muscle disease, pathophysiology, and pharmacology. This protocol describes techniques for dissociation of cells from human skeletal muscle biopsies and enrichment for a highly myogenic population by fluorescence-activated cell sorting (FACS). We also describe methods for assessing myogenicity and population expansion for subsequent in vitro study.
November 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29152527/novel-lrpprc-mutation-in-a-boy-with-mild-leigh-syndrome-french-canadian-type-outside-of-qu%C3%A3-bec
#16
Velda Xinying Han, Teresa S Tan, Furene S Wang, Stacey Kiat-Hong Tay
Background: Leigh syndrome, French-Canadian type is unique to patients from a genetic isolate in the Saguenay-Lac-Saint-Jean region of Québec. It has also been recently described in 10 patients with LRPPRC mutation outside of Québec. It is an autosomal recessive genetic disorder with fatal metabolic crisis and severe neurological morbidity in infancy caused by LRPPRC mutation. Methods and Results: The authors report a boy with a novel LRPPRC compound heterozygous missense mutations c...
January 2017: Child neurology open
https://www.readbyqxmd.com/read/29152137/emodin-and-rhein-decrease-levels-of-hypoxia-inducible-factor-1%C3%AE-in-human-pancreatic-cancer-cells-and-attenuate-cancer-cachexia-in-athymic-mice-carrying-these-cells
#17
Lijuan Hu, Rui Cui, Hongyi Liu, Feng Wang
The transcription factor hypoxia-inducible factor-1 (HIF-1) consists of oxygen-sensitive HIF-1α and constitutive HIF-1β. HIF-1α is undetectable in normal cells, but cancer cells frequently express HIF-1α to support their growth, angiogenesis, and high glycolysis (also known as the Warburg effect). The Warburg effect in cancer cells increases energy expenditure and thus participates in cancer-induced metabolic disorder, cancer cachexia. In the present study, we investigated whether two components of Rheum palmatum, emodin and rhein, inhibited HIF-1α expression in human pancreatic cancer cells and whether the inhibiting effect, if any, attenuated cancer cachexia...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151827/tumor-necrosis-factor-like-weak-inducer-of-apoptosis-regulates-quadriceps-muscle-atrophy-and-fiber-type-alteration-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#18
Jun-Juan Lu, Qing Wang, Li Hua Xie, Qiang Zhang, Sheng Hua Sun
Background: In chronic obstructive pulmonary disease (COPD), weakness and muscle mass loss of the quadriceps muscle has been demonstrated to predict survival and mortality rates of patients. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), as a member of the TNF superfamily, has recently been identified as a key regulator of skeletal muscle wasting and metabolic dysfunction. So our aim was to study the role of TWEAK during quadriceps muscle atrophy and fiber-type transformation in COPD model rats and its possible pathway...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/29151592/diet-resistant-obesity-is-characterized-by-a-distinct-plasma-proteomic-signature-and-impaired-muscle-fiber-metabolism
#19
A B Thrush, G Antoun, M Nikpay, D A Patten, C DeVlugt, J-F Mauger, B L Beauchamp, P Lau, R Reshke, É Doucet, P Imbeault, R Boushel, D Gibbings, J Hager, A Valsesia, R Slack, O Y Al-Dirbashi, R Dent, R McPherson, M-E Harper
BACKGROUND/OBJECT: Inter-individual variability in weight loss during obesity treatment is complex and poorly understood. Here we use whole body and tissue approaches to investigate fuel oxidation characteristics in skeletal muscle fibers, cells, and distinct circulating protein biomarkers before and after a high fat meal (HFM) challenge in those who lost the most (obese diet-sensitive; ODS), vs the least (obese diet-resistant; ODR) amount of weight in a highly controlled weight management program...
November 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29151281/skeletal-muscle-performance-and-ageing
#20
REVIEW
Michael Tieland, Inez Trouwborst, Brian C Clark
The world population is ageing rapidly. As society ages, the incidence of physical limitations is dramatically increasing, which reduces the quality of life and increases healthcare expenditures. In western society, ~30% of the population over 55 years is confronted with moderate or severe physical limitations. These physical limitations increase the risk of falls, institutionalization, co-morbidity, and premature death. An important cause of physical limitations is the age-related loss of skeletal muscle mass, also referred to as sarcopenia...
November 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
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