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squamous cell carcinoma transplant

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https://www.readbyqxmd.com/read/27890239/interleukin-22-and-cyclosporine-in-aggressive-cutaneous-squamous-cell-carcinoma
#1
REVIEW
Alexis L Santana, Diane Felsen, John A Carucci
Cutaneous squamous cell carcinomas (SCCs) account for up to 10,000 deaths annually in the United States. Most of the more than 700,000 SCCs diagnosed are cured by excision with clear margins; however, metastasis can occur despite seemingly adequate treatment in some cases. Immune-suppressed organ transplant recipients are 60 to 100 times more likely to develop SCC than immune-competent individuals. Transplant-associated SCCs occur more frequently and behave more aggressively, showing higher risk of recurrence and metastasis...
January 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/27868407/-effect-of-dj-1-silencing-by-rna-interference-on-growth-of-xenografted-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-in-nude-mice
#2
Zhisen Shen, Hongxia Deng, Dong Ye, Jian Zhang, Shijie Qiu, Qun Li, Xiang Cui
Objective: To investigate the effect of silencing DJ-1 on xenografted human laryngeal squamous cell carcinoma (LSCC) Hep-2 cells in nude mice. Methods: Xenograft model of human LSCC was established by subcutaneous transplantation of Hep-2 cells in 24 nude mice. The LSCC-bearing nude mice were randomly divided into 3 groups (n=8 in each):DJ-1 siRNA low dose group and DJ-1 siRNA high dose group were injected in tumors with 20 μg of DJ-1 siRNA or 40 μg of DJ-1 siRNA in 50 μL, respectively; control group was injected with 5% glucose solution in 50 μL, twice a week for 3 weeks...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27853649/cd24-blunts-oral-squamous-cancer-development-and-dampens-the-functional-expansion-of-myeloid-derived-suppressor-cells
#3
Caroline W Fugle, Yongliang Zhang, Feng Hong, Shaoli Sun, Caroline Westwater, Saleh Rachidi, Hong Yu, Elizabeth Garret-Mayer, Keith Kirkwood, Bei Liu, Zihai Li
CD24 expression has been implicated in the oncogenesis of multiple types of cancer and high tumor expression is considered a poor prognosis factor; however, the role of CD24 in oral cancer progression is unknown. Unlike other cancer types, we found that higher CD24 levels in human oral cancers are correlated to lower clinical stage and better overall survival. We then dissected the role of CD24 and mechanisms in oral cancer pathogenesis in mice using a genetic strategy and demonstrated that CD24 deficiency increased the oral cavity tumor burden in response to the carcinogen 4-nitroquioline 1-oxide (4-NQO)...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27843579/a-prospective-clinical-trial-to-assess-lapatinib-effects-on-cutaneous-squamous-cell-carcinoma-and-actinic-keratosis
#4
D Jenni, M B Karpova, B Mühleisen, J Mangana, J Dreier, J Hafner, R Dummer
BACKGROUND: Antiepidermal growth factor receptor (EGFR)-targeted therapy is widely used in many epithelial cancer types. We investigated lapatinib effects on cutaneous squamous cell carcinoma (cSCC) scheduled for resection and in coexisting precursor lesions (actinic keratosis (AK) and Bowen's disease (BD)) in a phase 2 mode of action clinical trial including a histological workup of the cSCC. PATIENTS AND METHODS: We initiated a prospective single-centre, open-label, non-controlled clinical study with translational intentions to investigate changes in size and histopathological features in cSCC after a 14-day period of neoadjuvant lapatinib therapy at a dose of 1500 mg/day prior to surgery, to quantify the impact on AK and BD in the same patient after 56 days and to evaluate the tolerability in patients with cSCC and precursor lesions...
2016: ESMO Open
https://www.readbyqxmd.com/read/27827319/the-salivary-microbiome-and-oral-cancer-risk-a-pilot-study-in-fanconi-anemia
#5
C P Furquim, G M S Soares, L L Ribeiro, M A Azcarate-Peril, N Butz, J Roach, K Moss, C Bonfim, C C Torres-Pereira, F R F Teles
Fanconi anemia (FA) is a rare genetic disease characterized by chromosomal instability and impaired DNA damage repair. FA patients develop oral squamous cell carcinoma (OSCC) earlier and more frequently than the general population, especially after hematopoietic stem cell transplantation (HSCT). Although evidence of an etiological role of the local microbiome and carcinogenesis has been mounting, no information exists regarding the oral microbiome of FA patients. The aim of this study was to explore the salivary microbiome of 61 FA patients regarding their oral health status and OSCC risk factors...
November 8, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27810163/surgical-site-infection-in-clean-contaminated-wounds-after-multimodal-treatment-of-advanced-oral-squamous-cell-carcinoma
#6
Christina Eder-Czembirek, Cornelia Czembirek, Pamela Braun, Christos Perisanidis, Rudolf Seemann
OBJECTIVES: The aim of this study was to assess the incidence rate for surgical site infections (SSI), patient- and therapy-related risk factors in UICC stage III and IV oral squamous cell carcinoma patients treated with preoperative radiochemotherapy, ablative surgery and immediate microvascular free flap reconstruction. MATERIAL AND METHODS: This retrospective analysis included 85 patients with oral squamous cell carcinoma treated by neoadjuvant radiochemotherapy, tumor surgery and immediate free flap reconstruction...
September 29, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27782094/photodynamic-therapy-and-non-melanoma-skin-cancer
#7
REVIEW
Liezel L Griffin, John T Lear
Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen's disease (BD) and actinic keratosis (AK). A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX (PpIX) is produced then activated by the introduction of a light source. Daylight-mediated MAL (methyl aminolaevulinate) PDT for AKs has the advantage of decreased pain and better patient tolerance...
October 22, 2016: Cancers
https://www.readbyqxmd.com/read/27717097/p16-immunostaining-in-keratinocytic-neoplasia-in-organ-transplant-recipients-bowen-s-disease-shows-a-characteristic-pattern-r1
#8
R E Genders, S Beck, J N Bouwes Bavinck, H A M van den Munckhof, S T P Kouwenhoven, M N C de Koning, F R de Gruijl, D Jenkins, R Willemze, K D Quint
BACKGROUND: For selecting therapy it is important to distinguish different types of keratinocytic neoplasia. It is sometimes difficult to make histopathologic diagnosis, especially in organ transplant recipients (OTR) who develop numerous lesions. METHODS: To investigate p16 immunostaining in different types of keratinocytic neoplasia in OTR, we studied 59 actinic keratoses(AK), 51 Bowen' s disease(BD), 63 squamous cell carcinomas(SCC) , 16 benign keratotic lesions(BKL) from 31 OTR patients and 25 controls (eczema and psoriasis)...
October 7, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27699266/cyclosporine-a-immunosuppression-drives-catastrophic-squamous-cell-carcinoma-through-il-22
#9
Melody Abikhair, Hiroshi Mitsui, Valerie Yanofsky, Nazanin Roudiani, Channa Ovits, Teddy Bryan, Tatiana M Oberyszyn, Kathleen L Tober, Juana Gonzalez, James G Krueger, Diane Felsen, John A Carucci
Immune-suppressed organ transplant recipients (OTRs) can develop catastrophic squamous cell carcinoma (SCC), characterized by multiple primary tumors, extensive body surface area involvement, or metastases. There are currently no curative systemic therapies available. We previously showed that IL-22 enhances SCC proliferation. Herein, we examined links between cyclosporine (CSA), IL-22, and SCC in patients, cell lines, and mice with UV light-induced SCC. Eighteen of 114 OTRs developed catastrophic SCC, which was strongly associated with CSA treatment...
June 2, 2016: JCI Insight
https://www.readbyqxmd.com/read/27678492/voriconazole-increases-the-risk-for-cutaneous-squamous-cell-carcinoma-after-lung-transplantation
#10
Nicholas A Kolaitis, Erin Duffy, Alice Zhang, Michelle Lo, David Torres Barba, Meng Chen, Teresa Soriano, Jenny Hu, Vishad Nabili, Rajeev Saggar, David M Sayah, Ariss DerHovanessian, Michael Y Shino, Joseph P Lynch, Bernie M Kubak, Abbas Ardehali, David J Ross, John A Belperio, David Elashoff, Rajan Saggar, S Samuel Weigt
Lung transplant recipients (LTR) are at high risk of cutaneous squamous cell carcinoma (SCC). Voriconazole exposure after lung transplant has recently been reported as a risk factor for SCC. We sought to study the relationship between fungal prophylaxis with voriconazole and the risk of SCC in sequential cohorts from a single center. We evaluated 400 adult LTR at UCLA between 7/1/2005 and 12/22/2012. On 7/1/2009 our center instituted a protocol switch from targeted to universal antifungal prophylaxis for at least 6 months post-transplant...
September 28, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27663613/one-year-review-of-the-screen-skin-cancer-post-transplant-clinic-what-we-have-learned
#11
Sarah Baldwin, Sheila Au
The Skin Cancer Post-Transplant (SCREEN) Clinic is a skin-cancer screening clinic that is fully integrated into the renal transplantation clinic at St Paul's Hospital in Vancouver, British Columbia. The purpose of this review was to determine characteristics of patients most at risk for skin cancer, to specify types and locations of skin cancers diagnosed, and to identify areas for patient and physician education. Transplant patients (91% renal; 5% heart) screened by a dermatologist during a 12-month period were stratified into low-, medium-, and high-risk groups based on detailed history and skin examination...
September 23, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27629775/intratumoral-photodynamic-therapy-with-newly-synthesized-pheophorbide-a-in-murine-oral-cancer
#12
Mee-Young Ahn, Hyo-Eun Yoon, Seong-Yong Moon, Yong-Chul Kim, Jung-Hoon Yoon
Photodynamic therapy (PDT) is a therapeutic alternative for malignant tumors that uses a photosensitizer. Our group recently synthesized photosensitizer Pheophorbide a (Pa) from chlorophyll-a. The present study investigated the therapeutic effect of PDT using intratumoral administration of the synthetic photosensitizer Pa in an in vivo murine oral squamous cell carcinoma (OSCC) animal model. Pa accumulation was measured using the fluorescence spectrum and imaging in living C3H mice. Intratumoral treatment of Pa-PDT (IT Pa-PDT) significantly inhibited the growth of transplanted OSCC cells...
September 13, 2016: Oncology Research
https://www.readbyqxmd.com/read/27617821/two-thirds-lip-defects-a-new-combined-reconstructive-technique-for-patients-with-epithelial-cancer
#13
Tiziana Vitagliano, Lucia Stella Curto, Antonio Greto Ciriaco, Pietro Gareri, Diego Ribuffo, Manfredi Greco
BACKGROUND: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and adipose tissue transplant. METHODS: The study was lead in the Plastic and Reconstructive Surgery Department of the University of Catanzaro...
September 9, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27593938/tumour-cell-derived-wnt5b-modulates-in-vitro-lymphangiogenesis-via-induction-of-partial-endothelial-mesenchymal-transition-of-lymphatic-endothelial-cells
#14
S-H Wang, J S Chang, J-R Hsiao, Y-C Yen, S S Jiang, S-H Liu, Y-L Chen, Y-Y Shen, J-Y Chang, Y-W Chen
Metastasis of the cervical lymph nodes frequently leads to poor survival of patients with oral squamous cell carcinoma (OSCC). The underlying mechanisms of lymph node metastasis are unclear. Wingless-type MMTV integration site family, member 5B (WNT5B), one component of the WNT signal pathway, was markedly up-regulated in OSCC sublines with high potential of lymphatic metastasis compared to that in OSCC cells with low nodal metastasis. Increased WNT5B mRNA was demonstrated in human OSCC tissues in comparison with adjacent non-tumorous tissues...
September 5, 2016: Oncogene
https://www.readbyqxmd.com/read/27584866/actinic-keratosis-related-signs-predictive-of-squamous-cell-carcinoma-in-renal-transplant-recipients-a-nested-case-control-study
#15
Z Jiyad, P O'Rourke, H P Soyer, A C Green
BACKGROUND: Squamous cell carcinoma (SCC) and intraepidermal carcinoma (IEC) commonly arise in actinically damaged skin. OBJECTIVE: To identify clinical features of actinic change that correlate with an increased risk of SCC or IEC in the short-medium term as guidance for prioritising field treatment. METHODS: In a nested case-control study, cases were renal transplant recipients (RTRs) who developed an incident SCC or IEC within 18 months following baseline examination and photography...
September 1, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27579740/non-melanoma-skin-cancer-in-portuguese-kidney-transplant-recipients-incidence-and-risk-factors
#16
André Pinho, Miguel Gouveia, José Carlos Cardoso, Maria Manuel Xavier, Ricardo Vieira, Rui Alves
BACKGROUND: Cancer is currently among the three leading causes of death after solid organ transplantation and its incidence is increasing. Non-melanoma skin cancer - squamous cell carcinoma and basal cell carcinoma - is the most common malignancy found in kidney transplant recipients (KTRs). The incidence of non-melanoma skin cancer in KTRs has not been extensively studied in Portugal. OBJECTIVES: To determine the incidence of non-melanoma skin cancer in KTRs from the largest Portuguese kidney transplant unit; and to study risk factors for non-melanoma skin cancer...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27566401/irf4-polymorphism-is-associated-with-cutaneous-squamous-cell-carcinoma-in-organ-transplant-recipients-a-pigment-independent-phenomenon
#17
Maryam M Asgari, Amanda E Toland, Sarah T Arron
No abstract text is available yet for this article.
August 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27547865/cancer-and-mtor-inhibitors-in-transplant-recipients
#18
Johan W de Fijter
Malignancy is the second most common single cause of death observed in organ transplant recipients. The excess cancer risk is related to intensity and duration of immunosuppressive therapy and inversely to recipient age. Immunodeficiency and (chronic/oncogenic) viral infections together constitute a major risk. Nonmelanoma skin cancer, Kaposi sarcoma and posttransplant lymphoproliferative disease (PTLD) have standardized incidence ratios exceeding 10- or 50-fold. The mammalian target of rapamycin (mTOR) inhibitors, sirolimus and everolimus, are increasingly used after organ transplantation with potential advantages in virus-associated post-transplant malignancies as well as anti-cancer properties...
August 10, 2016: Transplantation
https://www.readbyqxmd.com/read/27512993/keratin-17-is-induced-in-oral-cancer-and-facilitates-tumor-growth
#19
Rumana Khanom, Chi Thi Kim Nguyen, Kou Kayamori, Xin Zhao, Keiichi Morita, Yoshio Miki, Ken-Ichi Katsube, Akira Yamaguchi, Kei Sakamoto
Keratin subtypes are selectively expressed depending on the cell type. They not only provide structural support, but regulate the metabolic processes and signaling pathways that control the growth of the epithelium. KRT17 (keratin 17) is induced in the regenerative epithelium and acts on diverse signaling pathways. Here, we demonstrate that KRT17 is invariably and permanently induced in oral squamous cell carcinoma (OSCC), as revealed by immunohistochemistry and cDNA microarray analysis. Two representative OSCC cell lines; KRT17-weakly expressing Ca9-22 and KRT17-highly expressing HSC3 were used to establish KRT17-overexpressing Ca9-22 and KRT17-knockdown HSC3 cells...
2016: PloS One
https://www.readbyqxmd.com/read/27500260/open-label-randomized-study-of-transition-from-tacrolimus-to-sirolimus-immunosuppression-in-renal-allograft-recipients
#20
Helio Tedesco-Silva, V Ram Peddi, Ana Sánchez-Fructuoso, Brad A Marder, Graeme R Russ, Fritz Diekmann, Alison Flynn, Carolyn M Hahn, Huihua Li, Michael A Tortorici, Seth L Schulman
UNLABELLED: Calcineurin inhibitor-associated nephrotoxicity and other adverse events have prompted efforts to minimize/eliminate calcineurin inhibitor use in kidney transplant recipients. METHODS: This open-label, randomized, multinational study evaluated the effect of planned transition from tacrolimus to sirolimus on kidney function in renal allograft recipients. Patients received tacrolimus-based immunosuppression and then were randomized 3 to 5 months posttransplantation to transition to sirolimus or continue tacrolimus...
April 2016: Transplantation Direct
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