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https://www.readbyqxmd.com/read/29166499/skin-disorders-in-renal-transplant-recipients-a-retrospective-study
#1
Pedro Miguel Clemente Garrido, João Borges-Costa
BACKGROUND: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. OBJECTIVES: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. METHODS: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29102913/inhibitory-effect-of-aloe-emodin-mediated-photodynamic-therapy-on-human-oral-mucosa-carcinoma-in-vitro-and-in-vivo
#2
Yun-Qing Liu, Pei-Song Meng, Hong-Chao Zhang, Xu Liu, Meng-Xi Wang, Wen-Wu Cao, Zheng Hu, Zhi-Guo Zhang
We report a study on inhibition of human oral squamous cell carcinoma in vitro and in vivo, using novel photosensitizer (PS) aloe emodin (AE) mediated photodynamic therapy (PDT). Distinct morphology changes of oral mucosa carcinoma KB cells were observed under an optical microscope and cell migrations were inhibited owing to AE-PDT. The cell proliferation was blocked in G1 phase and the apoptosis increase were both caused by massive reactive oxygen species (ROS) generated from photoactivated AE. The upregulation of Caspase-3 and Bax protein levels and downregulation of Bcl-2 protein levels were observed after AE-PDT...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29093575/liver-transplant-recipients-have-a-higher-prevalence-of-anal-squamous-intraepithelial-lesions
#3
A Albuquerque, H Pessegueiro Miranda, J Lopes, J Gandara, S Rodrigues, R Gaspar, R Morais, R Ramalho, E Rodrigues-Pinto, H Cardoso, H Barroca, C C Dias, F Carneiro, G Macedo
BACKGROUND: Anal squamous intraepithelial lesions (ASIL) are precancerous lesions of anal squamous cell carcinoma, with a higher prevalence in immunosuppressed patients. There are some studies in kidney transplant recipients, but there is no information regarding prevalence in liver transplantation. Our aim was to evaluate the prevalence of ASIL in this setting. METHODS: Prospective case-control study involving liver transplant recipients without any other known risk factor for ASIL (n=59), which were compared with a healthy control group (n=57)...
October 31, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29072095/in-vitro-and-in-vivo-antitumour-effects-of-phenylboronic-acid-against-mouse-mammary-adenocarcinoma-4t1-and-squamous-carcinoma-sccvii-cells
#4
Maja Marasovic, Sinisa Ivankovic, Ranko Stojkovic, Damir Djermic, Borivoj Galic, Mladen Milos
The cytotoxic activity of phenylboroxine acid was evaluated in vitro on mouse mammary adenocarcinoma 4T1, mouse squamous cell carcinoma SCCVII, hamster lung fibroblast V79 and mouse dermal fibroblasts L929 cell lines. The cytotoxic effects were dose dependent for all tested tumour and non-tumour cell lines. Under in vivo conditions, three application routes of phenylboronic acid were studied: intra-peritoneal (i.p.), intra-tumour (i.t.) and per-oral. After tumour transplantation in syngeneic mice, phenylboronic acid was shown to slow the growth of both tumour cell lines (4T1 and SCCVII) compared with the control...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29057176/the-effect-of-conversion-from-a-calcineurin-inhibitor-to-sirolimus-on-skin-cancer-reduction-in-post-renal-transplantation-patients
#5
REVIEW
Aaron Smith, Wei Niu, Anand Desai
In kidney transplant patients, skin cancer is the most commonly involved neoplasm. More than 90% of post-transplantation skin cancers are nonmelanoma skin cancers (NMSCs). The majority of them are squamous cell carcinomas and basal cell carcinomas. Calcineurin inhibitors (CNIs) such as cyclosporine and tacrolimus are immunosuppressive agents given after solid organ transplantation, but they can also promote tumor growth. Sirolimus is a novel class of immunosuppressants and has been proven to have antineoplastic properties...
August 13, 2017: Curēus
https://www.readbyqxmd.com/read/29052902/towards-the-use-of-precision-medicine-in-predicting-cutaneous-squamous-cell-carcinoma-risk-among-solid-organ-transplant-recipients
#6
COMMENT
M O Nguyen, H T Nguyen, M M Asgari
No abstract text is available yet for this article.
October 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29051281/cancer-in-the-national-cancer-institute-inherited-bone-marrow-failure-syndrome-cohort-after-15-years-of-follow-up
#7
Blanche P Alter, Neelam Giri, Sharon A Savage, Philip S Rosenberg
The National Cancer Institute Inherited Bone Marrow Failure Syndromes Cohort enrolls patients with the four major syndromes: Fanconi anemia, dyskeratosis congenita, Diamond Blackfan anemia, and Shwachman Diamond syndrome, and follows them with a common comprehensive protocol. The current analysis includes more than double the numbers of patients and person-years since our first report in 2010. Patients with Fanconi anemia and dyskeratosis congenita developed head and neck and anogenital squamous cell carcinomas at rates that are hundreds-fold greater than the general population...
October 19, 2017: Haematologica
https://www.readbyqxmd.com/read/29049612/long-term-change-in-the-risk-of-skin-cancer-after-organ-transplantation-a-population-based-nationwide-cohort-study
#8
Syed Mohammad Husain Rizvi, Bjarte Aagnes, Hallvard Holdaas, Einar Gude, Kristin Muri Boberg, Øystein Bjørtuft, Per Helsing, Torbjørn Leivestad, Bjørn Møller, Petter Gjersvik
Importance: The high risk of skin cancer after organ transplantation is a major clinical challenge and well documented, but reports on temporal trends in the risk of posttransplant cutaneous squamous cell carcinoma (SCC) are few and appear contradictory. Objective: To study temporal trends for the risk of skin cancer, particularly SCC, after organ transplantation. Design, Setting, and Participants: Population-based, nationwide, prospective cohort study of 8026 patients receiving a kidney, heart, lung, or liver transplant in Norway from 1968 through 2012 using patient data linked to a national cancer registry...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29031659/validity-of-skin-cancer-malignancy-reporting-to-the-organ-procurement-transplant-network-a-cohort-study
#9
Giorgia L Garrett, Joyce T Yuan, Thuzar M Shin, Sarah T Arron
BACKGROUND: The Organ Procurement Transplant Network (OPTN) registry collects data on posttransplant malignancies in solid organ transplant recipients. Complete and accurate registry data on skin cancer is critical for research on epidemiology and interventions. OBJECTIVE: The study goal was to determine the validity of Organ Procurement Transplant Network skin cancer data. METHODS: This cohort study compared reporting of posttransplant squamous cell carcinoma (SCC) and malignant melanoma (MM) in OPTN to medical-record review-derived data from the Transplant Skin Cancer Network (TSCN) database...
October 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29024374/human-papillomavirus-and-posttransplantation-cutaneous-squamous-cell-carcinoma-a-multicenter-prospective-cohort-study
#10
Jan N Bouwes Bavinck, Mariet C W Feltkamp, Adele C Green, Marta Fiocco, Sylvie Euvrard, Catherine A Harwood, Charlotte M Proby, Luigi Naldi, Janouk C D Diphoorn, Anna Venturuzzo, Gianpaolo Tessari, Ingo Nindl, Francesca Sampogna, Damiano Abeni, Rachel E Neale, Jelle J Goeman, Koen D Quint, Anne B Halk, Carmen Sneek, Roel E Genders, Maurits N C de Koning, Wim G V Quint, Ulrike Wieland, Sönke Weissenborn, Tim Waterboer, Michael Pawlita, Herbert Pfister
Organ transplant recipients (OTRs) have a 100-fold increased risk of cutaneous squamous cell carcinoma (cSCC). We prospectively evaluated the association between β genus human papillomaviruses (βPV) and keratinocyte carcinoma in OTRs. Two OTR cohorts without cSCC were assembled: cohort 1 was transplanted in 2003-2006 (n = 274) and cohort 2 was transplanted in 1986-2002 (n = 352). Participants were followed until death or cessation of follow-up in 2016. βPV infection was assessed in eyebrow hair by using polymerase chain reaction-based methods...
October 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28994104/epidemiology-of-keratinocyte-carcinomas-after-organ-transplantation
#11
REVIEW
M M Madeleine, N S Patel, E I Plasmeijer, E A Engels, J N Bouwes Bavinck, A E Toland, A C Green
Keratinocyte carcinoma (KC) is the most common type of cancer among white populations, but it is even more common among solid organ transplant recipients (OTRs). The most frequent histological type of KC among OTRs is cutaneous squamous cell carcinoma (cSCC), followed by basal cell carcinoma, although the reverse is seen in the general population. Metastatic cSCCs are more frequent, and mortality is increased compared with immunocompetent populations. There is strong evidence that the risk of KC among OTRs rises with increasing time after transplantation and older age at transplantation, and that KC is enhanced in those with sun-damaged skin...
October 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28992218/long-term-consequences-of-renal-insufficiency-in-children-lessons-learned-from-the-dutch-leric-study
#12
Jaap W Groothoff, Martin Offringa, Martha Grootenhuis, Kitty J Jager
Few data exist on the prospects in adulthood for children on chronic renal replacement therapy (RRT). This article summarizes the results of a comprehensive Dutch long-term follow-up study performed in 2000 and 2010 of patients with RRT onset at age <15 years between 1972 and 1992. After a median of 25.5 RRT years, patients had stayed 23% of RRT time on dialysis. We observed a 30 times greater mortality risk compared with age-matched peers with cardiovascular disease (CVD) as the main cause of death during 1972-2000 and infections during 2000-10...
July 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28987229/controversies-in-oral-and-maxillofacial-oncology
#13
REVIEW
Kyle S Ettinger, Jacob G Yetzer
Imaging studies are essential components of tumor diagnosis, staging, assessing tumor response to neoadjuvant and adjuvant therapies, and postoperative surveillance on completion of definitive treatment. Treatment of early stage clinically node negative oral cavity squamous cell carcinoma is controversial. Approximately 3% of all head and neck tumors arise within the parotid gland and most often within the superficial lobe, lateral to the facial nerve; about 80% are benign and most are pleomorphic adenoma. In patients with dry eyes failing multiple other treatment modalities and facing ongoing pain and loss of vision, microvascular transplant of the submandibular gland is a viable option...
November 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28971762/chemoprevention-of-skin-carcinomas-in-high-risk-transplant-recipients
#14
Paola Savoia, Elisa Zavattaro, Ottavio Cremona
Long-term immunosuppressive therapy, as provided to solid organ transplant recipients, inevitably results in a significant inhibition of immune defenses; this leads to frequent skin infections and malignancies, which represent an important cause of morbidity and mortality for transplanted patients. The incidence and risk of skin carcinomas are elevated in solid organ transplant recipients in comparison with the general population, with a 10-fold increased risk for basal cell carcinoma and a 50-100-fold for squamous cell carcinoma...
October 3, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28954025/surgical-amniotic-membrane-transplantation-after-conjunctival-and-limbal-tumor-excision
#15
Seniz Engur Goktas, Yasemin Katircioglu, Tuba Celik, Firdevs Ornek
Purpose: To evaluate the clinical results of patients treated by amniotic membrane transplantation (AMT) following excision of conjunctival and limbal tumors. Methods: A total of 14 eyes of 14 patients who underwent AMT after total lesion-free tumor excision and perilesional cryotherapy were evaluated. Results: The excised tumors comprised 7 conjunctival intraepithelial neoplasia, 5 conjunctival nevus, 1 primary acquired melanosis, and 1 squamous cell carcinoma...
July 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28952522/in-vitro-growth-of-human-keratinocytes-and-oral-cancer-cells-into-microtissues-an-aerosol-based-microencapsulation-technique
#16
Wai Yean Leong, Chin Fhong Soon, Soon Chuan Wong, Kian Sek Tee, Sok Ching Cheong, Siew Hua Gan, Mansour Youseffi
Cells encapsulation is a micro-technology widely applied in cell and tissue research, tissue transplantation, and regenerative medicine. In this paper, we proposed a growth of microtissue model for the human keratinocytes (HaCaT) cell line and an oral squamous cell carcinoma (OSCC) cell line (ORL-48) based on a simple aerosol microencapsulation technique. At an extrusion rate of 20 μL/min and air flow rate of 0.3 L/min programmed in the aerosol system, HaCaT and ORL-48 cells in alginate microcapsules were encapsulated in microcapsules with a diameter ranging from 200 to 300 μm...
May 14, 2017: Bioengineering
https://www.readbyqxmd.com/read/28952162/risk-prediction-tools-for-keratinocyte-carcinoma-after-solid-organ-transplantation-a-review-of-the-literature
#17
REVIEW
S E Lowenstein, G Garrett, A E Toland, A Jambusaria-Pahlajani, M M Asgari, A Green, E A Engels, S T Arron
Long-term iatrogenic immunosuppression increases the risk of cutaneous malignancies in organ transplant recipients (OTRs), particularly the keratinocyte cancers basal cell carcinoma and cutaneous squamous cell carcinoma (cSCC). cSCC is the most common malignancy in OTRs, with the risk increased to over 65-fold in transplanted patients relative to the general population. There have been very few risk prediction tools developed for accurate determination of the risk of developing keratinocyte cancers in the OTR population...
September 26, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28943917/mechanisms-of-cxcr7-induction-in-malignant-melanoma-development
#18
Xiao-Jing Li, Pai Liu, Wei-Wei Tian, Zhi-Feng Li, Bao-Guo Liu, Jian-Fang Sun
Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C-X-C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. The present study sought to investigate the effects of CXCR7 on MM development. First, CXCR7 expression levels were assessed in the skin tumor tissue of patients with MM. Then, CXCR7 small hairpin RNA was used in M14 melanoma cells in a Transwell culture model and in a transplanted mouse model to test the effects of CXCR7...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28939069/current-mouse-models-of-oral-squamous-cell-carcinoma-genetic-and-chemically-induced-models
#19
REVIEW
Kazuhisa Ishida, Hiroyuki Tomita, Takayuki Nakashima, Akihiro Hirata, Takauji Tanaka, Toshiyuki Shibata, Akira Hara
Oral squamous cell carcinoma (OSCC) patients have a low 5-year survival rate and poor prognosis. To improve survival and prognosis, the causes and processes involved in lesion development should be evaluated. For this purpose, the use of OSCC mouse models, such as chemically induced mouse models, genetically modified mouse models, and transplanted (xenograft) models, is crucial. These OSCC models exhibit both advantages and disadvantages when studying OSCC development and progression. Until a model resembling human OSCC is developed, both the advantages and disadvantages of each model should be carefully considered...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28927055/silencing-dna-methyltransferase-1-leads-to-the-activation-of-the-esophageal-suppressor-gene-p16-in-vitro-and-in-vivo
#20
Jian Bai, Xue Zhang, Bangqing Liu, Haiyong Wang, Zhenzong Du, Jianfei Song
Previous studies have demonstrated that DNA methyltransferase 1 (DNMT1) is required for the maintenance of DNA methylation and epigenetic changes that may lead to the development of esophageal squamous cell carcinoma (ESCC). In order to investigate whether the silencing of DNMT1 protects tumor suppressor genes, including p16, and is able to be used as a potential therapy for human ESCC, short hairpin RNA targeting DNMT1 (shRNA-DNMT1) was synthesized and transfected into the human ESCC lines KYSE150 and KYSE410, which were then injected into the backs of nude mice prior to harvesting...
September 2017: Oncology Letters
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