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squamous cell carcinoma transplant

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https://www.readbyqxmd.com/read/28927055/silencing-dna-methyltransferase-1-leads-to-the-activation-of-the-esophageal-suppressor-gene-p16-in-vitro-and-in-vivo
#1
Jian Bai, Xue Zhang, Bangqing Liu, Haiyong Wang, Zhenzong Du, Jianfei Song
Previous studies have demonstrated that DNA methyltransferase 1 (DNMT1) is required for the maintenance of DNA methylation and epigenetic changes that may lead to the development of esophageal squamous cell carcinoma (ESCC). In order to investigate whether the silencing of DNMT1 protects tumor suppressor genes, including p16, and is able to be used as a potential therapy for human ESCC, short hairpin RNA targeting DNMT1 (shRNA-DNMT1) was synthesized and transfected into the human ESCC lines KYSE150 and KYSE410, which were then injected into the backs of nude mice prior to harvesting...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925042/clinical-comparison-of-actinic-changes-preceding-squamous-cell-carcinoma-vs-intraepidermal-carcinoma-in-renal-transplant-recipients
#2
Z Jiyad, P O'Rourke, H P Soyer, A C Green
Intraepidermal carcinoma (IEC) is a type of in situ squamous cell carcinoma (SCC), although progression of IEC is rare. We sought to investigate differences between the actinic skin changes preceding the development of both SCC and IEC. Photographs of 63 skin sites at which either SCC or IEC subsequently developed in 37 renal transplant recipients (RTRs) were examined for features of actinic change. We found that areas of skin with an actinic keratosis (AK) > 1 cm(2) in size were four times more likely to develop SCC as opposed to IEC (OR = 4...
September 19, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28898527/voriconazole-and-squamous-cell-carcinoma-after-lung-transplantation-a-multicenter-study
#3
B Hamandi, C Fegbeutel, F P Silveira, E A Verschuuren, M Younus, J Mo, J Yan, P Ussetti, P V Chin-Hong, A Solé, C L Holmes-Liew, E M Billaud, P A Grossi, O Manuel, D J Levine, R G Barbers, D Hadjiliadis, J Aram, L G Singer, S Husain
This study evaluated the independent contribution of voriconazole to the development of squamous cell carcinoma (SCC) in lung transplant recipients, by attempting to account for important confounding factors, particularly immunosuppression. This international, multicenter, retrospective, cohort study included adult patients who underwent lung transplant during 2005-2008. Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC...
September 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28885213/presentation-of-a-variation-of-the-chorioallantoic-membrane-set-up-as-a-potential-model-for-individual-therapy-for-squamous-cell-carcinoma-of-the-oropharynx
#4
P Kauffmann, M Troeltzsch, R Cordesmeyer, P I Heidekrueger, H Schliephake, M Canis, H A Wolff, M Rave-Fraenk, P Stroebel, A Kehrer, L Prantl, T Aung
The chorioallantoic membrane of fertilized chicken eggs in an early phase of breeding presents an approved test situation for the growth and treatment of human cancer cells.These models work due to the inoculation of cells into the membrane that stays within the egg shell during the time of investigation. In this study a modification of this model is presented. Samples of native tumors, rather than cell lines, are transplanted into the membrane and the body of the egg is taken out of the shell and placed in a plastic bowl...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28853496/incidence-and-regression-of-actinic-keratoses-in-organ-transplant-recipients
#5
Zainab Jiyad, Louise Marquart, Peter O'Rourke, Adèle C Green
Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Negative binomial regression and Poisson regression models were used to estimate rate ratios (RR) for these 3 outcomes. Among 150 renal and 89 liver OTRs, those who spent > 50% of a typical weekday in the sun had a lower rate of AK regression than those who spent minimal time in the sun during a typical weekday...
August 30, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28819442/interferon-%C3%AE-promotes-the-expression-of-cancer-stem-cell-markers-in-oral-squamous-cell-carcinoma
#6
Hailong Ma, Shufang Jin, Wenyi Yang, Zhuowei Tian, Shuli Liu, Yang Wang, Ge Zhou, Mei Zhao, Shalva Gvetadze, Zhiyuan Zhang, Jingzhou Hu
Objectives: IFNα can stimulate an antitumor immune response and has a direct inhibition on cancer cells. This study is to test whether IFNα can activate dormant cancer stem cell (CSC) in oral squamous cell carcinoma (OSCC) to facilitate their elimination by chemotherapy. Materials and methods: Nude mouse transplantation tumor model was established and administrated with IFNα and saline. The influence on CD44 and ALDH1A1 expression under IFNα treatment was detected by in vivo experiments. Flow cytometry, western blot, and immunofluorescence were used to detect the expression of CD44 and ALDH1A1 after INFa treatment in OSCC cell lines...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28797445/characteristics-and-long-term-outcomes-of-head-and-neck-squamous-cell-carcinoma-after-solid-organ-transplantation
#7
Samer Alsidawi, Katharine A Price, Ashish V Chintakuntlawar, Gustavo F Westin, Joaquin J Garcia, Daniel J Ma, Scott H Okuno
INTRODUCTION: Immunosuppression after solid organ transplant prevents graft rejection, but leads to increased incidence of various malignancies including head and neck squamous cell carcinoma (HNSCC). Outcomes of patients with post-transplant HNSCC are unknown. MATERIALS AND METHODS: We retrospectively identified patients who developed HNSCC after solid organ transplant between 1995 and 2010. Adults with pathology-proven HNSCC and adequate follow up were included...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28780363/effect-of-voriconazole-on-risk-of-nonmelanoma-skin-cancer-after-hematopoietic-cell-transplantation
#8
Lawrence F Kuklinski, Shufeng Li, Margaret R Karagas, Wen-Kai Weng, Bernice Y Kwong
BACKGROUND: Voriconazole has previously been associated with increased risk for cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients. Less is known about the risk in patients after hematopoietic cell transplantation (HCT). OBJECTIVE: We evaluated the effect of voriconazole on the risk for nonmelanoma skin cancer (NMSC), including SCC and basal cell carcionoma, among those who have undergone allogeneic and autologous HCT. METHODS: In all, 1220 individuals who had undergone allogeneic HCT and 1418 who had undergone autologous HCT were included in a retrospective cohort study...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28736001/evaluating-retention-of-skin-cancer-education-in-kidney-transplant-recipients-reveals-a-window-of-opportunity-for-re-education
#9
P H Patel, K Bibee, G Lim, S M Malik, C Wu, M Pugliano-Mauro
BACKGROUND: Skin cancer is the most common malignancy after solid organ transplant and can lead to significant morbidity. The likelihood of developing squamous cell carcinomas and melanomas is 100 and 2.4 times more likely, respectively, in kidney transplant recipients when compared with the general population. There are few data regarding the assessment and influence of solid organ transplant recipient (SOTR) knowledge of skin cancer and its effect on short- and long-term awareness and behavior...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28679298/prevalence-of-cutaneous-viral-infections-in-incident-cutaneous-squamous-cell-carcinoma-detected-among-chronic-lymphocytic-leukemia-and-hematopoietic-stem-cell-transplant-patients
#10
Shalaka S Hampras, Frederick L Locke, Julio C Chavez, Nishit S Patel, Anna R Giuliano, Kyle Miller, Tarik Gheit, Massimo Tommasino, Dana E Rollison
The role of cutaneous viral infections in the development of non-melanoma skin cancer (NMSC), including cutaneous squamous cell carcinoma (SCC), among chronic lymphocytic leukemia (CLL) and blood and marrow transplant (BMT) patients is not established. CLL (n = 977) and BMT (n = 3587) patients treated at the Moffitt Cancer Center were included in a retrospective cohort study. Human papillomavirus (HPV) and human polyomavirus (HPyV) DNA were examined in a subset of incident SCC tumors. Five-year cumulative incidence of NMSC was 1...
July 6, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28656204/effects-of-bufalin-on-the-mtor-p70s6k-pathway-and-apoptosis-in-esophageal-squamous-cell-carcinoma-in-nude-mice
#11
Yao Liu, Xu Wang, Ying Jia, Yueping Liu
The aim of this study was to investigate the effects of bufalin on the mammalian target of rapamycin (mTOR/p70S6 kinase (p70S6K) signaling pathway and cell apoptosis in orthotopically transplanted tumors in nude mice. The mice were inoculated with human esophageal squamous cell carcinoma (ESCC) ECA109 cells in order to establish a model of orthotopicall transplanted ESCC tumors. The mice are administered low, medium and high doses of bufalin (0.5, 1.0 and 1.5 mg/kg) or rapamycin, or a combination of both...
June 23, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28646606/vismodegib-for-recurrent-locally-destructive-basal-cell-carcinoma-in-a-renal-transplant-patient
#12
P Koelblinger, R Dummer, M Laimer, S Hecht, J W Bauer, A Gaggl, A Kugler
Solid organ transplant patients are at an increased risk of developing cutaneous malignancies owing to long-lasting immunosuppression. The strongest increase in incidence (35-fold) has been reported for cutaneous squamous cell carcinoma [1]. Basal cell carcinoma (BCC) may occur even more frequently, especially during the first years after transplantation [2]. The hedgehog-inhibitor vismodegib has been safely used for the treatment of locally advanced or metastatic BCC in immunocompetent patients since 2012 [3]...
June 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28645931/a-potential-role-of-the-unfolded-protein-response-in-post-transplant-cancer
#13
REVIEW
Sandra Bodeau, Chloé Sauzay, Olivier Pluquet, Gabriel Choukroun, Antoine Galmiche
Cancer is one of the major causes of mortality in organ transplant patients receiving immunosuppressive regimen based on Cyclosporin A (CsA). Organ transplantation and chronic immunosuppression are typically associated with skin cancers (both squamous cell carcinoma and melanoma) and renal cell carcinoma (RCC). Recent studies have shown that in addition to its immunosuppressive effects, accounted for by the inhibition of calcineurin and the modulation of the transcriptional programme of lymphocytes, CsA also directly stimulates the growth and aggressive behaviour of various cancer cells...
July 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28632809/acquired-epidermodysplasia-verruciformis-occurring-in-a-renal-transplant-recipient
#14
Jill K Henley, Eric W Hossler
Acquired epidermodysplasia verruciformis (EDV) is a rare condition occurring in patients with depressed cellular immunity, particularly individuals with human immunodeficiency virus (HIV). Acquired EDV is less commonly reported in recipients of stem cell or solid organ transplantation. This condition typically manifests within 5 years of initial immunosuppression and can present as multiple hypopigmented to red, tinea versicolor-like macules or as multiple verrucous, flat-topped papules distributed over the trunk, arms, and legs...
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28615224/risk-of-second-malignancies-in-solid-organ-transplant-recipients-who-develop-keratinocyte-cancers
#15
Rachel D Zamoiski, Elizabeth Yanik, Todd M Gibson, Elizabeth K Cahoon, Margaret M Madeleine, Charles F Lynch, Sally Gustafson, Marc T Goodman, Melissa Skeans, Ajay K Israni, Eric A Engels, Lindsay M Morton
Solid organ transplant recipients have increased risk for developing keratinocyte cancers, including cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), in part as a result of immunosuppressive medications administered to prevent graft rejection. In the general population, keratinocyte cancers are associated with increased risks of subsequent malignancy, however, the risk in organ transplant populations has not been evaluated. We addressed this question by linking the U.S. Scientific Registry of Transplant Recipients, which includes data on keratinocyte cancer occurrence, with 15 state cancer registries...
August 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28556451/skin-cancers-in-organ-transplant-recipients
#16
REVIEW
A Mittal, O R Colegio
Long-term utilization of immunosuppression in organ transplant recipients (OTRs) leads to decreased immune-mediated tumor surveillance and development of malignant tumors. A delicate balance needs to be maintained in the intensity of immunosuppression to keep the risk of malignancy low without jeopardizing life-saving graft function. OTRs are prone to developing skin cancers that exhibit unique epidemiologic, pathophysiologic, and prognostic characteristics. In this review, we discuss the most commonly reported skin cancers in OTRs: squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Kaposi sarcoma, Merkel cell carcinoma, and malignant melanoma (MM)...
May 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28545381/prevalence-and-clinical-significance-of-visible-oral-lesions-in-patients-with-fanconi-anemia-at-risk-for-head-and-neck-cancer
#17
Eunike Velleuer, Ralf Dietrich, Amy Frohnmayer, Natalia Pomjanski, Laura E Hays, Stefan Biesterfeld
Fanconi anemia is a genetic bone marrow failure syndrome, variably associated with congenital anomalies and a sharply increased risk for epithelial malignancies. During the past 20 years, hematopoietic stem cell transplantation (HSCT) has dramatically improved survival. However, compared to the general population, FA patients are at greatly increased risk, and at a much younger age, for squamous cell carcinomas (SCC) of the oral cavity, esophagus and the anogenital region. The relative risk and age of onset appears to negatively correlate with HSCT in FA patients...
May 24, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28526809/tumor-cell-specific-aim2-regulates-growth-and-invasion-of-cutaneous-squamous-cell-carcinoma
#18
Mehdi Farshchian, Liisa Nissinen, Elina Siljamäki, Pilvi Riihilä, Minna Piipponen, Atte Kivisaari, Markku Kallajoki, Reidar Grénman, Juha Peltonen, Sirkku Peltonen, Koen D Quint, Jan Nico Bouwes Bavinck, Veli-Matti Kähäri
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal keratinocytes revealed upregulation of the expression of AIM2 mRNA and protein in cSCC cells. Elevated levels of AIM2 mRNA were noted in cSCCs in vivo compared with normal skin. Strong and moderate tumor cell specific expression of AIM2 was detected with immunohistochemistry (IHC) in sporadic human cSCCs in vivo, whereas expression of AIM2 was moderate in cSCC in situ (cSCCIS) and low or absent in actinic keratosis (AK) and normal skin...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28507493/comparison-of-the-incidence-of-skin-cancers-in-patients-on-dialysis-and-after-kidney-transplantation
#19
Joanna Sułowicz, Anna Wojas-Pelc, Ewa Ignacak, Katarzyna Krzanowska, Marek Kuźniewski, Władysław Sułowicz
INTRODUCTION: Kidney transplant (KTx) patients on immunosuppressive therapy are predisposed to the development of infections and cancers. AIM: To compare the incidence and type of malignant skin lesions in kidney transplant patients and the dialyzed population based on the initiated dermatologic screening. MATERIAL AND METHODS: The study included 598 patients: 486 kidney transplant recipients and 112 patients on maintenance dialysis. All the patients underwent dermatological examination...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28501488/laminaria-japonica-polysaccharides-effectively-inhibited-the-growth-of-nasopharyngeal-carcinoma-cells-in-vivo-and-in-vitro-study
#20
Manli Zeng, Xingyu Wu, Fen Li, Wensheng She, Lin Zhou, Benyuan Pi, Zhiwen Xu, Xiaolin Huang
AIMS: Laminaria Japonica Polysaccharides (LJP) is a kind of plant polysaccharide isolated from Laminaria Japonica Aresch. LJP has a variety of biological activity, including anti-tumor, improving immune function, anti-radiation and others. This study observed the biological activity of LJP in vitro and in vivo on human nasopharyngeal carcinoma(NPC), and the possible anticancer mechanism was explored. METHODS: Nasopharyngeal poorly differentiated squamous cell carcinoma cell lines CNE2 and HONE1 were used for the study...
May 10, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
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