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https://www.readbyqxmd.com/read/29315147/nonmelanoma-skin-cancer-risk-in-patients-with-inflammatory-bowel-disease-undergoing-thiopurine-therapy-a-systematic-review-of-the-literature
#1
Joshua W Hagen, Melissa A Pugliano-Mauro
BACKGROUND: Azathioprine and 6-mercaptopurine (thiopurines) are common adjunct treatments for inflammatory bowel disease (IBD). Although thiopurine therapy in organ transplant recipients is known to increase nonmelanoma skin cancers (NMSCs), dermatologic literature yields less data regarding NMSC risk of thiopurine use in IBD. OBJECTIVE: The aim of this study was to systematically review current literature on NMSC risk in patients with IBD using thiopurine therapy...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29313973/mouse-model-of-post-surgical-primary-tumor-recurrence-and-regional-lymph-node-metastasis-progression-in-hpv-related-head-and-neck-cancer
#2
Maxime Mermod, Agnès Hiou-Feige, Esther Bovay, Vincent Roh, Jana Sponarova, Massimo Bongiovanni, Daniel W Vermeer, John H Lee, Tatiana V Petrova, Jean-Paul Rivals, Yan Monnier, Genrich V Tolstonog, Christian Simon
HPV-positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of post-surgical high-risk features, i.e., positive surgical margins and extracapsular spread (ECS). In this increasingly complex emerging framework of HNSCC treatment, representative pre-clinical models are needed to support future clinical trials and advances in personalized medicine. Here, we present an immunocompetent mouse model based on the implantation of mouse tonsil epithelial HPV16-E6/E7-expressing cancer cells into the submental region of the floor-of-the-mouth...
January 4, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29307647/subsequent-non-melanoma-skin-cancers-and-impact-of-immunosuppression-in-liver-transplant-recipients
#3
Pamela Funk-Debleds, Emilie Ducroux, Olivier Guillaud, José Ursic-Bedoya, Evelyne Decullier, Mélanie Vallin, Sylvie Euvrard, Georges-Philippe Pageaux, Olivier Boillot, Jérôme Dumortier
BACKGROUND: Non-melanoma skin cancers (NMSC) are the most frequent cancers in solid organ transplant recipients, with a high rate of subsequent tumors. OBJECTIVES: To describe subsequent NMSC in a large cohort of liver transplant recipients (LTR) with long follow-up, and to analyze the factors influencing it, including immunosuppressive regimen. METHODS: Ninety-eight LTR (76 male) with a personal post-transplant history of squamous-cell carcinoma (SCC), basal-cell carcinoma (BCC) or Bowen's disease were included, with a median follow-up of 12...
January 4, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29298428/although-abundant-in-tumor-tissue-mast-cells-have-no-effect-on-immunological-micro-milieu-or-growth-of-hpv-induced-or-transplanted-tumors
#4
Shanawaz Mohammed Ghouse, Anastasia Polikarpova, Lina Muhandes, Jan Dudeck, Iliana Tantcheva-Poór, Karin Hartmann, Matthias Lesche, Andreas Dahl, Sabine Eming, Werner Müller, Rayk Behrendt, Axel Roers
High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse. Equipped with numerous pattern recognition receptors and capable of executing important pro-inflammatory responses, mast cells are considered innate sentinels that significantly impact tumor biology. Mast cells were reported to promote human papilloma virus (HPV)-induced epithelial hyperproliferation and neo-angiogenesis in an HPV-driven mouse model of skin cancer...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29282394/treatment-of-multiple-actinic-keratosis-and-field-of-cancerization-with-topical-piroxicam-0-8-and-sunscreen-50-in-organ-transplant-recipients-a-series-of-10-cases
#5
Virginia Garofalo, Alessandra Ventura, Sara Mazzilli, Laura Diluvio, Luca Bianchi, Luca Toti, Giuseppe Tisone, Massimo Milani, Elena Campione
Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29250172/association-between-integrin-linked-kinase-and-hyperthermia-in-oral-squamous-cell-carcinoma
#6
Jun Zhao, Na Liu, Xinhe Hao, Lin Que, Jiyuan Liu, Xiufa Tang
The present study aimed to observe the effect of the biological functions of integrin-linked kinase (ILK) silencing combined with hyperthermia on Tca8113 cells. Lentivirus-mediated short hairpin RNA (shRNA)-targeting ILK was transfected into oral squamous cell carcinoma (OSCC) Tca8113 cells and, combined with hyperthermia, several experimental methods were used to detect their biological behavior in vitro. On the basis of in vitro experiments, Tca8113 cells were transplanted into nude mice models, and ILK-shRNA-lentivirus was injected into the nude mice transplanted tumor and combined with hyperthermia...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29249251/-what-s-new-in-oncodermatology
#7
C Lebbé
This 'What's new in oncodermatology?' addresses the developments in 2017 on the epidemiology and management of skin cancers. We observe a constant increase in carcinomas, risk factors for squamous cell carcinoma, especially in transplant recipients where skin cancer mortality is important. Among epidemiological developments in melanoma are increased mortality despite screening, occupational exposure to UV, second melanoma and higher risk after carcinoma. New classifications that should be considered are AJCC8 for melanoma and carcinoma...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29245973/microrna-433-inhibits-oral-squamous-cell-carcinoma-cells-by-targeting-fak
#8
Yong-Jian Wang, Zi-Feng Zhang, Shao-Hua Fan, Juan Zhuang, Qun Shan, Xin-Rui Han, Xin Wen, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Bin Qiao, Qian Tao, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
We investigated the involvement of microRNA-433 (miR-433) in the proliferation, migration, and invasiveness of oral squamous cell carcinoma (OSCC). Totally 108 OSCC tissues and adjacent normal tissues from patients with OSCC were collected. Also, transplanted tumor formation experiment in nude mice was conducted to verify the effect of miR-433 and FAK on subcutaneous transplanted tumor. The CD44+ stem cell from SCC-9 were collected and assigned into the blank, miR-433 mimics, mimics control, miR-433 inhibitors, inhibitors control, siFAK and miR-433 inhibitors + siFAK groups...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29237362/de-novo-malignancies-after-liver-transplantation-a-single-institution-experience
#9
Tufan Egeli, Tarkan Unek, Mucahit Ozbilgin, Cihan Agalar, Serhan Derici, Mesut Akarsu, Ilkay Tugba Unek, Murat Aysin, Aylin Bacakoglu, Ibrahim Astarcıoglu
OBJECTIVES: Our objective was to analyze characteristics, risk factors, and incidence of de novo malignancies after liver transplant. MATERIALS AND METHODS: The hospital records of 557 patients who underwent liver transplant were analyzed from the point of de novo malignancy development. We evaluated the demographic features and survival of these patients retrospectively. RESULTS: The research covered 429 patients, 9 (2%) of whom developed de novo malignancy...
December 14, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29235161/management-of-actinic-keratosis-at-specific-body-sites-in-patients-at-high-risk-of-carcinoma-lesions-expert-consensus-from-the-akteam%C3%A2-of-expert-clinicians
#10
REVIEW
M A Richard, J M Amici, N Basset-Seguin, J P Claudel, B Cribier, B Dreno
BACKGROUND: Actinic keratoses (AK) arise on sun-exposed regions of the skin. If left untreated, AK may progress to invasive squamous cell carcinoma (SCC), although the rate of progression is low. A practical treatment algorithm for the treatment of AK in standard situations has been published by the AKTeam™ expert panel. However, management of particular situations of AK with increasing/higher carcinoma risk or AK progressing into carcinomas with increased aggressiveness due to their anatomical location (risky areas), or in patients with an increased risk of SCC requires further discussion...
December 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29234120/oral-epithelial-cell-sheets-engraftment-for-esophageal-strictures-after-endoscopic-submucosal-dissection-of-squamous-cell-carcinoma-and-airplane-transportation
#11
Naoyuki Yamaguchi, Hajime Isomoto, Shinichiro Kobayashi, Nobuo Kanai, Kengo Kanetaka, Yusuke Sakai, Yoshiyuki Kasai, Ryo Takagi, Takeshi Ohki, Hiroko Fukuda, Tsutomu Kanda, Kazuhiro Nagai, Izumi Asahina, Kazuhiko Nakao, Masayuki Yamato, Teruo Okano, Susumu Eguchi
Endoscopic submucosal dissection (ESD) permits en bloc removal of superficial oesophageal squamous cell carcinoma (ESCC). However, post-procedure stricture is common after ESD for widespread tumours, and multiple endoscopic balloon dilation (EBD) procedures are required. We aimed to evaluate the safety and effectiveness of endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets that had been transported by air over a distance of 1200 km in controlling postprocedural oesophageal stricture...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29218012/anti-tumor-effect-of-rhaponticum-uniflorum-ethyl-acetate-extract-by-regulation-of-peroxiredoxin1-and-epithelial-to-mesenchymal-transition-in-oral-cancer
#12
Hui Chen, Chunxiao Wang, Moci Qi, Lihua Ge, Zhenchuan Tian, Jinhua Li, Min Zhang, Min Wang, Linfang Huang, Xiaofei Tang
Objective: To explore whether Rhaponticum uniflorum (R. uniflorum) had anti-tumor effects in oral cancer and investigate the molecular mechanisms involved in these anti-tumor effects. Methods: Chemical compositions of R. uniflorum ethyl acetate (RUEA) extracts were detected by ultra-performance liquid chromatography-Q/time-of-flight mass spectrometry (UPLC-Q/TOF-MS), followed by pharmacology-based network prediction analysis. The effects of RUEA extracts on proliferation, apoptosis, migration, and invasion ability of human oral squamous cell carcinoma (OSCC) cell line SCC15 were evaluated by CCK8 assay, Annexin V- fluorescein isothiocyanate/propidium iodide staining, wound healing assay, and Matrigel invasion assay, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29217883/squamous-cell-carcinoma-of-skin-after-20-years-of-renal-transplantation
#13
J Poddar, A D Sharma, S Patel, U Suryanarayana
Solid organ transplant recipients are at high risk of developing malignancies due to the prolonged use of immunosuppressant drugs. Squamous cell carcinoma of skin can occur in these patients even after decades of organ transplant. A 45-year-old male underwent renal transplant for end-stage renal disease 23 years ago and was on immunosuppressive drugs since then. The patient was on regular follow-up. Three years back, he developed squamous cell carcinoma of both forearms and hands, which was treated with radiation therapy using 8 MeV electrons, by parallel opposed fields to a dose of 60 Gy/30 fractions...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29198659/incidence-of-infectious-disease-and-malignancies-after-rituximab-therapy-in-kidney-transplant-recipients-results-from-a-cohort-in-germany
#14
E Schrezenmeier, K Budde, O Staeck, L Lehner, M Duerr, D Khadzhynov, T Dörner, F Halleck
BACKGROUND: Rituximab is frequently used in solid organ transplantation off-label, especially in patients with renal allografts. Few data are available on the safety aspects of solid organ transplant recipients receiving rituximab. There is a knowledge gap on long-term follow-up data, in particular on infectious complications. PATIENTS AND METHODS: A retrospective observational registry study (German Registry on Autoimmune Diseases) comprising a total of 681 patients was conducted...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29192981/organ-transplantation-and-cutaneous-squamous-cell-carcinoma-progress-pitfalls-and-priorities-in-immunosuppression-associated-keratinocyte-carcinoma
#15
EDITORIAL
C A Harwood, S T Arron, C M Proby, M M Asgari, J N Bouwes Bavinck, A C Green, A E Toland
No abstract text is available yet for this article.
November 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29167858/cutaneous-squamous-cell-carcinomas-in-solid-organ-transplant-recipients-compared-with-immunocompetent-patients
#16
Joyce Y Cheng, Fang-Yong Li, Christine J Ko, Oscar R Colegio
Importance: Solid organ transplant recipients (SOTRs) have a 100-fold increased risk of squamous cell carcinoma (SCC), and they may develop more aggressive SCCs compared with immunocompetent individuals. Objective: To compare outcomes associated with aggressive behavior of SCC in SOTRs and high-risk immunocompetent patients. Design, Setting, and Participants: A retrospective cohort study of 58 SOTRs and 40 immunocompetent patients evaluated at the Yale Transplant Dermatology Clinic in New Haven, Connecticut, who had at least 1 SCC confirmed histopathologically between January 1, 2008, and December 31, 2015...
November 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29166499/skin-disorders-in-renal-transplant-recipients-a-retrospective-study
#17
Pedro Miguel Clemente Garrido, João Borges-Costa
BACKGROUND: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. OBJECTIVES: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. METHODS: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29102913/inhibitory-effect-of-aloe-emodin-mediated-photodynamic-therapy-on-human-oral-mucosa-carcinoma-in-vitro-and-in-vivo
#18
Yun-Qing Liu, Pei-Song Meng, Hong-Chao Zhang, Xu Liu, Meng-Xi Wang, Wen-Wu Cao, Zheng Hu, Zhi-Guo Zhang
We report a study on inhibition of human oral squamous cell carcinoma in vitro and in vivo, using novel photosensitizer (PS) aloe emodin (AE) mediated photodynamic therapy (PDT). Distinct morphology changes of oral mucosa carcinoma KB cells were observed under an optical microscope and cell migrations were inhibited owing to AE-PDT. The cell proliferation was blocked in G1 phase and the apoptosis increase were both caused by massive reactive oxygen species (ROS) generated from photoactivated AE. The upregulation of Caspase-3 and Bax protein levels and downregulation of Bcl-2 protein levels were observed after AE-PDT...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29093575/liver-transplant-recipients-have-a-higher-prevalence-of-anal-squamous-intraepithelial-lesions
#19
A Albuquerque, H Pessegueiro Miranda, J Lopes, J Gandara, S Rodrigues, R Gaspar, R Morais, R Ramalho, E Rodrigues-Pinto, H Cardoso, H Barroca, C C Dias, F Carneiro, G Macedo
BACKGROUND: Anal squamous intraepithelial lesions (ASIL) are precancerous lesions of anal squamous cell carcinoma, with a higher prevalence in immunosuppressed patients. There are some studies in kidney transplant recipients, but there is no information regarding prevalence in liver transplantation. Our aim was to evaluate the prevalence of ASIL in this setting. METHODS: Prospective case-control study involving liver transplant recipients without any other known risk factor for ASIL (n=59), which were compared with a healthy control group (n=57)...
October 31, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29072095/in-vitro-and-in-vivo-antitumour-effects-of-phenylboronic-acid-against-mouse-mammary-adenocarcinoma-4t1-and-squamous-carcinoma-sccvii-cells
#20
Maja Marasovic, Sinisa Ivankovic, Ranko Stojkovic, Damir Djermic, Borivoj Galic, Mladen Milos
The cytotoxic activity of phenylboroxine acid was evaluated in vitro on mouse mammary adenocarcinoma 4T1, mouse squamous cell carcinoma SCCVII, hamster lung fibroblast V79 and mouse dermal fibroblasts L929 cell lines. The cytotoxic effects were dose dependent for all tested tumour and non-tumour cell lines. Under in vivo conditions, three application routes of phenylboronic acid were studied: intra-peritoneal (i.p.), intra-tumour (i.t.) and per-oral. After tumour transplantation in syngeneic mice, phenylboronic acid was shown to slow the growth of both tumour cell lines (4T1 and SCCVII) compared with the control...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
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