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https://www.readbyqxmd.com/read/28405677/metastasized-murine-oral-squamous-cell-carcinoma-cells-induce-intratumoral-polymorphonuclear-myeloid-derived-suppressor-cells
#1
Shigeki Sumi, Naoki Umemura, Eiji Takayama, Emika Ohkoshi, Makoto Adachi, Masako Mizuno-Kamiya, Toshihiro Inagaki, Harumi Kawaki, Shinichiro Sumitomo, Nobuo Kondoh
Myeloid derived suppressor cells (MDSCs) localize to hematopoietic organs and peripheral blood during inflammation or tumor tissues and lymph nodes in the presence of a tumor. However, whether there are differences in MDSCs found in the primary tumor and metastases is unknown. In the present study, we established a cell line of metastasized tumor cells to a lymph node, L5-11, which were derived from the Sq-1979 mouse buccal mucosa squamous cell carcinoma cell line. We then analyzed tumor immunogenicity, especially with regard to MDSCs, to clarify the differences between the primary tumor and metastases, using an isogenic heterotopic tumor transplantation model...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28403126/effector-antitumor-and-regulatory-t-cell-responses-influence-the-development-of-nonmelanoma-skin-cancer-in-kidney-transplant-patients
#2
Elena Crespo, Loreto Fernandez, Marc Lúcia, Edoardo Melilli, Ricardo Lauzurica, Rosa Maria Penin, Ariadna Quer, Sergio Luque, Maria Quero, Anna Manonelles, Joan Torras, Josep Maria Cruzado, Laura Cañas, Josep Maria Grinyó, Oriol Bestard
BACKGROUND: Chronic immunosuppression promotes Nonmelanocytic Squamous Cell Carcinoma (SCC) after kidney transplantation. Adaptive and innate immunity play a key role controlling tumor growth and are influenced by different immunosuppressive agents. We hypothesized that functional impairment of tumor-specific T cell responses due to CNI could contribute to SCC development, whereas conversion to mTOR-i could recover this protective immune response. METHODS: Peripheral tumor-specific T cell responses against main SCC-derived antigens using the IFN-γ ELISPOT assay and intratumor and circulating immune phenotypes (CD4+T, CD8+T, CD20+B, CD56+NK, FOXP3+Tregs) were explored in a cross-sectional analysis in 59 kidney transplant patients with SCC on CNI (KT-CNI-SCC) or mTOR-i (KT-mTORi-SCC), 25 nontransplants developing SCC (NoKT-SCC) and 6 healthy controls...
April 11, 2017: Transplantation
https://www.readbyqxmd.com/read/28387492/-skin-carcinogenesis-in-renal-transplant-recipients
#3
REVIEW
G E Piérard, C Piérard-Franchimont, P Delvenne
Organ transplants are bound to the induction and upkeep of immunosuppression. The immunomodulatory regimen modalities have changed over time with an improvement of the overage graft survival. The effects are also present on the skin and its cancerogenesis which is particularly activated for the squamous cell carcinoma. A review of the recent medical literature reveals the importance of searching squamous cell carcinomas, actinic keratoses, seborrheic keratoses and keratocanthomas before and after organ transplants...
March 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28387316/lkb1-inactivation-drives-lung-cancer-lineage-switching-governed-by-polycomb-repressive-complex-2
#4
Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S Herter-Sprie, Gang Lu, Xin Zhang, Bryan P Marsh, Stephanie J Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M Sholl, Anil K Rustgi, David J Kwiatkowski, J Alan Diehl, Adam J Bass, Norman E Sharpless, Glenn Dranoff, Peter S Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F Kim, Kwok-Kin Wong
Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, including Sox2, ΔNp63 and Ngfr. SCC lesions have higher levels of the H3K27 methyltransferase EZH2 than the ADC lesions, but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the SCC lesions...
April 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28377416/spectrum-of-immune-related-conditions-associated-with-risk-of-keratinocyte-cancers-among-elderly-adults-in-the-united-states
#5
Elizabeth L Yanik, Ruth M Pfeiffer, D Michael Freedman, Martin A Weinstock, Elizabeth K Cahoon, Sarah T Arron, Matthew Chaloux, M Kari Connolly, Priyadharsini Nagarajan, Eric A Engels
Elevated keratinocyte carcinoma (KC) risk is present with several immune-related conditions, e.g., solid organ transplantation and non-Hodgkin lymphoma. Because many immune-related conditions are rare, their relationships with KC have not been studied. We used Medicare claims to identify cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) cases in 2012, and controls matched on sex and age. All subjects were aged 65-95 years, of white race, and had attended ≥1 dermatologist visit in 2010-2011...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28367854/development-of-allograft-cancer-after-lung-transplantation-a-case-report
#6
Esther I Schwarz, Bart Vrugt, Lars C Huber, Christian Murer, Mace M Schuurmans, Ilhan Inci, Christian Benden
INTRODUCTION: In contrast to skin cancer and lymphoproliferative disorders, de-novo lung allograft cancer is seldom reported after lung transplantation. CASE REPORT: A 19-year-old patient with severe pulmonary hypertension listed urgently for lung transplantation underwent successful bilateral lung transplant procedure receiving lungs from a 55-year-old donor with a smoking history of 30 pack years. After 3.5 years of lung transplantation, a locally advanced squamous cell carcinoma in the left lung allograft was diagnosed...
March 29, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28343197/-skin-cancers-in-kidney-transplant-recipients
#7
Anna Bieryło, Szymon Brzósko, Elżbieta Laudańska, Beata Naumnik
Kidney transplantation is the best treatment for end-stage renal failure. It prolongs the patient's life, improves quality of life and reduces costs associated with renal replacement therapy. Increasingly, newer immunosuppressive regimens allow for the proper functioning of the transplanted organ for many years. The progress in transplantation, qualification patients in older age for the procedure and longer survival of kidney graft lead to an increase in the number of patients receiving immunosuppressive drugs...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28339026/opposite-effects-of-tumor-protein-d-tpd-52-and-tpd54-on-oral-squamous-cell-carcinoma-cells
#8
Kosuke Kato, Yoshiki Mukudai, Hiromi Motohashi, Chihiro Ito, Shinnosuke Kamoshida, Toshikazu Shimane, Seiji Kondo, Tatsuo Shirota
The tumor protein D52 (TPD52) protein family includes TPD52, -53, -54 and -55. Several reports have shown important roles for TPD52 and TPD53, and have also suggested the potential involvement of TPD54, in D52-family physiological effects. Therefore, we performed detailed expression analysis of TPD52 family proteins in oral squamous cell carcinoma (OSCC). Towards this end, TPD54-overexpressing or knocked-down cells were constructed using OSCC-derived SAS, HSC2 and HSC3 cells. tpd52 or tpd53 was expressed or co-expressed in these cells by transfection...
March 23, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28329671/trends-of-skin-cancer-incidence-following-transplantation-in-the-united-states
#9
Sarah T Arron
BackgroundSkin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTR), no study has estimated the post-transplant population-based incidence in the US. The objective of this study is to determine the incidence and evaluate the predictors of post-transplant skin cancer, including squamous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTR receiving a primary transplant in 2003 or 2008...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329649/human-papillomavirus-infection-and-squamous-cell-carcinoma-in-organ-transplant-recipients
#10
Jan Nico Bouwes Bavinck
Organ transplant recipients (OTR) have an increased risk of developing squamous cell carcinomas (SCC). SCC are usually associated with multiple warts and premalignant keratoses. This cohort study investigated the predictive effect of infection with beta papillomaviruses (betaPV) with the later development of cutaneous SCC.In an earlier prospective and case-control study, eyebrow hairs and sera of 743 OTR transplanted before 2003 were collected. BetaPV DNA was determined in eyebrow hairs and betaPV antibodies in sera...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28322198/multiple-and-recurrent-squamous-cell-carcinoma-of-the-oral-cavity-after-graft-versus-host-disease
#11
Xiuhong Weng, Yuzhen Xing, Bo Cheng
Oral squamous cell carcinoma (OSCC) is one of the most common secondary solid tumors in patients who have undergone hematopoietic stem cell transplantation (HSCT). However, according to previous reports, multiple and recurrent OSCC is very rare. The presented case shows the susceptibility to the development of secondary malignancies, particularly oral cancer, of patients who present with chronic graft-versus-host disease after HSCT. OSCC after HSCT appears to be more invasive and has a tendency to recur, with a poor prognosis...
February 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28300920/porokeratosis-of-mibelli-in-an-hiv-positive-patient
#12
Luiza de Queiroz Ottoni, Priscila Kakizaki, Rafael Ribeiro Pinheiro, José Alexandre de Souza Sittart, Neusa Yuriko Sakai Valente
Porokeratosis represents a group of disorders of epidermal keratinization that are characterized by one or more annular plaques surrounded by a histologically distinctive hyperkeratotic ridge-like border called the cornoid lamella. Many studies showed that organ transplantation and immunosuppression were associated in a significant number of cases. Furthermore, an association with squamous cell carcinoma and basal cell carcinoma has been noted in all variants of porokeratosis. The rarity of this disorder and its atypical clinical presentation - a single lesion on the thumb of an HIV-positive male patient - motivated this report...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28260475/nonmelanoma-skin-cancers-after-kidney-transplant-our-15-years-of-experience-with-mammalian-target-of-rapamycin-inhibitors
#13
Gokalp Okut, Alper Alp, Erhan Tatar, Cenk Simsek, Cem Tugmen, Adam Uslu
OBJECTIVES: We evaluated patients with nonmelanoma skin cancer after kidney transplant and the effects of immunosuppression reduction and switching to a mammalian target of rapamycin inhibitor drugs. MATERIALS AND METHODS: Kidney transplant recipients were evaluated retrospectively from patient medical records (between January 2000 and December 2014). A 30% increase in serum creatinine was accepted as indicating renal failure progression. RESULTS: Of 18 patients included (mean follow-up 98 ± 66 mo), 7 (38...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260147/establishment-and-characterization-of-a-squamous-cell-carcinoma-cell-line-designated-hzk-1-derived-from-a-metastatic-lymph-node-tumor-of-the-tongue
#14
Tetsuya Hirabayashi, Haruka Takahashi, Miho Watanabe, Toshiaki Tachibana
The hZK-1 cell line was successfully established from the metastatic foci of a lymph node of an 82-year-old Japanese woman with squamous cell carcinoma of the tongue. The pathological diagnosis of the tumor was moderately to well-differentiated squamous cell carcinoma. The hZK-1 cells were angular in shape, and had neoplastic and pleomorphic features. Adjacent hZK-1 cells were joined by desmosomes and well-developed microvilli, and many free ribosomes were observed in the cytoplasm. The doubling time of the hZK-1 cells was approximately 36, 33, and 29 h at the 10th, 20th, and 30th passages, respectively...
March 4, 2017: Human Cell
https://www.readbyqxmd.com/read/28259107/expression-of-programmed-cell-death-ligand-in-cutaneous-squamous-cell-carcinoma-and-treatment-of-locally-advanced-disease-with-pembrolizumab
#15
Mary L Stevenson, Claire Q F Wang, Melody Abikhair, Nazanin Roudiani, Diane Felsen, James G Krueger, Anna C Pavlick, John A Carucci
Importance: Limited therapies are available in patients with inoperable locally advanced cutaneous squamous cell carcinoma (cSCC). Objective: To determine the efficacy of programmed cell death 1 receptor (PD-1) inhibitors in locally advanced cSCC. Design, Setting, and Participants: A single patient with locally advanced cSCC who declined surgery and radiotherapy underwent treatment with pembrolizumab, an anti-PD-1 antibody, at an academic dermatologic surgery section and cancer center...
April 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28254442/long-term-incidence-of-secondary-malignancies-after-allogeneic-hematopoietic-cell-transplantation-a-single-center-experience
#16
Fotios V Michelis, Rouslan Kotchetkov, Rebecca M Grunwald, Aamir Azeem, Eshetu G Atenafu, Jeffrey H Lipton, David Loach, Vikas Gupta, John Kuruvilla, Dennis D Kim, Auro Viswabandya, Uday Deotare, Hans A Messner
To review the emergence of secondary malignancies (SMs) in recipients of allogeneic hematopoietic cell transplantation (HCT), we documented the occurrence of SMs in 2415 allogeneic HCT recipients, ages 18 to 71, in a single center over 4 decades. SMs were seen in 209 patients, including 58 with nonmetastatic squamous cell (SCC) and basal cell carcinoma (BCC) of the skin. Cumulative incidence of SM was 6.3% at 10 years, 13.5% at 20 years, and 17.6% at 30 years post-HCT. Median age at diagnosis of SMs was 61 years (range, 21 to 85)...
February 27, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28214216/cancer-stem-cell-cytokeratins-and-epithelial-to-mesenchymal-transition-markers-expression-in-oral-squamous-cell-carcinoma-derived-from-ortothopic-xenoimplantation-of-cd44-high-cells
#17
Nathália Paiva de Andrade, Maria Fernanda Setúbal Destro Rodrigues, Camila Oliveira Rodini, Fabio Daumas Nunes
Oral squamous cell carcinoma (OSCC) is the most prevalent neoplasia of oral cavity worldwide and prognosis remains unchanged in decades. Recently, different authors reported that head and neck squamous cell carcinomas have a subpopulation of tumor initiating cells that apparently correspond to cancer stem cells (CSC) and are also responsible for tumor growth and metastasis. The purpose of the present study was to investigate the microscopic and phenotypic characteristics of OSCC tumors induced after orthotopic xenoimplantation of SCC9(WT) cell line and CSC-enriched subpopulation isolated from SCC9 cell line based on high expression of the putative CSC marker CD44...
March 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28211039/cutaneous-squamous-cell-carcinoma-an-epidemiological-review
#18
REVIEW
A C Green, C M Olsen
Cutaneous squamous cell carcinoma (SCC) is a common cancer in white populations and its disease burden is often substantially underestimated. SCC occurs more often in men than women and increases dramatically with age; those affected often develop multiple primaries over time, which increases the burden. The main external cause is solar ultraviolet radiation (UVR), with immunosuppression being the other established risk factor, shown by the high SCC rates in organ transplant recipients. Sunbed use and certain genetic disorders and medical conditions are also associated with SCC, while associations with human papillomavirus infection and high bodyweight are not established...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28207636/association-between-pretransplant-cancer-and-survival-in-kidney-transplant-recipients
#19
Dag Olav Dahle, Tom Grotmol, Torbjørn Leivestad, Anders Hartmann, Karsten Midtvedt, Anna V Reisæter, Geir Mjøen, Hege K Pihlstrøm, Hege Næss, Hallvard Holdaas
BACKGROUND: Kidney transplantation in recipients with a previous malignancy is often deferred 2-5 years after cancer treatment due to fear of cancer recurrence. In Norway, the required waiting period has been 1 year. METHODS: We compared patient and graft survival of recipients with pretransplant cancer to the outcomes of matched recipients without such cancer (comparators) using Cox regression. RESULTS: From 1963 to 2010, 377 of 5867 recipients (6...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28202188/rate-of-regional-nodal-metastases-of-cutaneous-squamous-cell-carcinoma-in-the-immunosuppressed-patient
#20
Eamon J McLaughlin, Lauren Miller, Thuzar M Shin, Joseph F Sobanko, Steven B Cannady, Christopher J Miller, Jason G Newman
PURPOSE: Immunosuppressed solid organ transplant recipients (SOTRs) have an increased risk of developing cutaneous squamous cell carcinomas (cSCCs) with metastatic potential. This study sought to determine the rate of regional lymph node involvement in a large cohort of solid organ transplant patients with cutaneous head and neck squamous cell carcinoma. MATERIALS AND METHODS: A retrospective chart review was performed on solid organ transplant patients with head and neck cutaneous squamous cell carcinoma treated at a tertiary academic medical center from 2005 to 2015...
February 4, 2017: American Journal of Otolaryngology
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