keyword
https://read.qxmd.com/read/38490290/the-molecular-mechanism-of-action-for-the-potent-antitumor-component-extracted-using-supercritical-fluid-extraction-from-croton-crassifolius-root
#1
JOURNAL ARTICLE
Xu Guo, Rui-Rui Zhang, Jin-Yue Sun, Yan Liu, Xian-Shun Yuan, Ying-Ying Chen, Hui Sun, Chao Liu
ETHNOPHARMACOLOGICAL RELEVANCE: The root of Croton crassifolius has been used as a traditional Chinese medicine (TCM), called Radix Croton Crassifolius, and commonly known as "Ji Gu Xiang" in Chinese. Its medicinal value has been recorded in several medical books or handbooks, such as "Sheng Cao Yao Xing Bei Yao", "Ben Cao Qiu Yuan" and "Zhong Hua Ben Cao". It has been traditional employed for treating sore throat, stomach-ache, rheumatism and cancer. AIM OF THE STUDY: At present, there are limited studies on the evaluation of low-polarity extracts of roots in C...
March 13, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38484783/-sore-throat-and-hallucinations-an-unusual-course-of-ebv-associated-tonsillitis
#2
JOURNAL ARTICLE
Verena Strasser, Teresa Steinbichler, Susanne Dürr
No abstract text is available yet for this article.
March 14, 2024: Laryngo- Rhino- Otologie
https://read.qxmd.com/read/38478638/secondary-syphilis-presenting-as-leukocytoclastic-vasculitis-in-a-61-year-old-man
#3
JOURNAL ARTICLE
Nada Mohamed, Nicole N Dacy, Lisa M Lopez, Lindsay M Bicknell
Cutaneous lesions of secondary syphilis are highly infectious and can mimic many skin disorders, making the diagnosis more difficult. They typically present as generalized, nonpruritic erythematous-to-copper-colored macules and papules, characteristically involving palms and soles. In 80% of patients the rash develops insidiously. However, rare forms of secondary syphilis present as rapidly progressive papulopustular lesions. These forms of syphilis are usually associated with human immunodeficiency virus infection and immunosuppression...
October 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38473412/comparing-molnupiravir-to-nirmatrelvir-ritonavir-paxlovid-in-the-treatment-of-mild-to-moderate-covid-19-in-immunocompromised-cancer-patients
#4
JOURNAL ARTICLE
Andrea J Haddad, Ray Y Hachem, Mohamed Moussa, Ying Jiang, Hiba R Dagher, Patrick Chaftari, Anne-Marie Chaftari, Issam I Raad
BACKGROUND: Nirmatrelvir/Ritonavir has been shown to reduce the risk of COVID-19 progression by 88% compared to placebo, while Molnupiravir reduced it by 31%. However, these two agents have not been compared head-to-head. We therefore compared the safety and efficacy of both agents for the treatment of mild-to-moderate COVID-19 in immunocompromised cancer patients. METHODS: We identified 240 cancer patients diagnosed with COVID-19 and treated with Molnupiravir or Nirmatrelvir/Ritonavir...
March 5, 2024: Cancers
https://read.qxmd.com/read/38470893/multi-modal-deep-learning-methods-for-classification-of-chest-diseases-using-different-medical-imaging-and-cough-sounds
#5
JOURNAL ARTICLE
Hassaan Malik, Tayyaba Anees
Chest disease refers to a wide range of conditions affecting the lungs, such as COVID-19, lung cancer (LC), consolidation lung (COL), and many more. When diagnosing chest disorders medical professionals may be thrown off by the overlapping symptoms (such as fever, cough, sore throat, etc.). Additionally, researchers and medical professionals make use of chest X-rays (CXR), cough sounds, and computed tomography (CT) scans to diagnose chest disorders. The present study aims to classify the nine different conditions of chest disorders, including COVID-19, LC, COL, atelectasis (ATE), tuberculosis (TB), pneumothorax (PNEUTH), edema (EDE), pneumonia (PNEU)...
2024: PloS One
https://read.qxmd.com/read/38465442/ectopic-lingual-thyroid-with-subclinical-hypothyroidism-in-children
#6
Se Jin An, Min Hyung Cho, Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
OBJECTIVES: Lingual thyroid is a rare condition that affects approximately 1 in 100,000 individuals. Although it is usually detected in the pediatric population through newborn screening tests or evaluation of congenital hypothyroidism, there are cases in which it remains undetected until adulthood or until symptoms arise because of glandular enlargement. The possible symptoms of lingual thyroid include foreign body sensation in the throat, dysphagia, dyspnea, and hemorrhage. Several cases of lingual thyroid are asymptomatic and accompanied by subclinical hypothyroidism...
March 12, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38456797/group-a-streptococcus-pharyngitis-in-children-new-perspectives-on-rapid-diagnostic-testing-and-antimicrobial-stewardship
#7
JOURNAL ARTICLE
Jérémie F Cohen, Robert R Tanz, Stanford T Shulman
The most common cause of bacterial pharyngitis is Group A Streptococcus (GAS). Accurate diagnosis of GAS pharyngitis is crucial to identify children who would benefit from antibiotic treatment. Rapid diagnosis has the potential to reduce antibiotic overuse. Current national guidelines differ in their recommendations for GAS testing. While rapid antigen detection tests are widely used, their sensitivity is considered too low for stand-alone testing by several expert bodies. Newer molecular tests using nucleic acid amplification show higher accuracy and fast results, but their cost, complexity, and very high sensitivity may limit widespread adoption...
March 8, 2024: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/38455837/evaluation-of-olfactory-dysfunction-among-covid-19-patients-in-baghdad-iraq
#8
JOURNAL ARTICLE
Mohammad F Kasim, Azzam M Abbas
Background SARS‑CoV‑2 (COVID-19) causes olfactory dysfunction which is characterized by anosmia or hyposmia. Characterization of olfactory dysfunction has added value to the diagnosis and prognosis of the disease. Nevertheless, scarce information exists about COVID-19 patients suffering from olfactory dysfunction in Iraq. This study aimed to identify olfactory dysfunction (anosmia or hyposmia) in Iraqi COVID-19 patients and examine their response to smell exercise at Baghdad Medical City Complex, Baghdad, Iraq...
February 2024: Curēus
https://read.qxmd.com/read/38455626/factors-associated-with-the-quality-of-life-and-persistent-dyspnea-severity-in-covid-19-survivors-a-cross-sectional-study-among-healthcare-workers
#9
JOURNAL ARTICLE
Joshua P Sinaga, Bintang Ym Sinaga, Parluhutan Siagian, Putri C Eyanoer, Iduh M Unata
The coronavirus disease 2019 (COVID-19) pandemic had a significant impact on global health. The alterations in quality of life (QoL) and the persistent symptoms of dyspnea have been the healthcare workers' challenges during and after the pandemic. The aim of this study was to assess factors associated with the QoL and persistent dyspnea experienced by COVID-19 survivors, particularly among healthcare workers. A cross-sectional study was conducted among healthcare workers at H. Adam Malik General Hospital, Medan, Indonesia, using direct interviews to collect the data...
December 2023: Narra J
https://read.qxmd.com/read/38449947/case-of-lemierre-s-syndrome-presenting-with-neuro-ophthalmologic-complications-that-worsened-after-stopping-corticosteroids
#10
Aseel Abuhammad, Osayd Nassar, Mohammed G Tomizi, Khadeejeh Alfroukh, Abdelwadod Abuturki
Lemierre's syndrome (LS) is a rare disorder that manifests as septic internal jugular thrombophlebitis following a recent oropharyngeal infection. This article details a unique case of LS, where the patient presented to the emergency room with complaints of vomiting, headache, diplopia, and left eye pain. Due to a history of sore throat, headache, neck pain, fever, and nausea five days prior to admission, the patient was initially treated with amoxicillin/clavulanate for suspected tonsillitis. A positive meningeal sign and elevated temperature were observed during the clinical examination...
February 2024: Curēus
https://read.qxmd.com/read/38437659/a-case-of-sore-throat-and-vesicular-hand-lesions
#11
JOURNAL ARTICLE
Morgan Rayner
No abstract text is available yet for this article.
March 2024: Australian Journal of General Practice
https://read.qxmd.com/read/38430636/flurbiprofen-in-the-subglottic-space-to-prevent-postoperative-sore-throat-after-cardiac-surgery-a-randomized-double-blind-study
#12
JOURNAL ARTICLE
Maria Calabrese, Gabriella Arlotta, Maria Enrica Antoniucci, Luca Montini, Diana Giannarelli, Temistocle Taccheri, Filippo Corsi, Stefano De Paulis, Andrea Scapigliati, Francesca Bevilacqua, Joel Vargas, Michele Corrado, Natalia Pavone, Piergiorgio Bruno, Massimo Massetti, Franco Cavaliere
STUDY OBJECTIVE: Postoperative sore throat (POST) and hoarseness are common complications of tracheal intubation. This study aims to evaluate the efficacy of flurbiprofen administered through the subglottic port of tracheal tubes to prevent POST after cardiac surgery. DESIGN: Single-center, prospective, randomized, double-blind, placebo-controlled trial. SETTING: Tertiary Care Referral University Hospital (Fondazione Policlinico Universitario A...
March 1, 2024: Journal of Clinical Anesthesia
https://read.qxmd.com/read/38412322/exploration-of-the-utility-of-different-doses-of-qingfei-dayuan-granules-a-multicenter-randomized-double-blind-placebo-controlled-trial
#13
JOURNAL ARTICLE
Xiaoyun Zhu, Weinan Li, Yi Yang, Hengfei Li, Min Yang, Jilong Zhang, Xucheng Li, Guangjun Yan, Xiongfei Wu, Weijun Zhao, Mengdi Cui, Xi Yang, Xinyu Hu, Juan Huang, Yuanming Ba
BACKGROUND: Clinical studies have confirmed that Qingfei Dayuan (QFDY) granules are effective in the treatment of influenza and upper respiratory tract infections (URTIs) caused by pulmonary heat-toxin syndrome (PHTS). Granules of Chinese medicine formulations have become a widely used dosage form in clinical practice. With the continuous optimization of extraction technology, the advantages of Chinese medicine granules have been gradually demonstrated, but the price of Chinese medicine granules is generally higher than that of traditional dosage forms of Chinese medicine, and we support the rational use of the appropriate dosage of QFDY for patients with these conditions...
February 26, 2024: Aging
https://read.qxmd.com/read/38410011/postoperative-sore-throat-among-patients-following-general-anesthesia-with-endotracheal-intubation-in-a-tertiary-care-centre
#14
JOURNAL ARTICLE
Sabin Gauchan, Chitra Thapa, Rajiv Yadav, Sabin Bhandari
INTRODUCTION: Postoperative sore throat is the second most common minor adverse event after general anaesthesia with endotracheal intubation. It is an uncomfortable and stressful sequel of tracheal intubation. The incidence of postoperative sore throat varies across different studies and type of anesthesia technique used. The aim of the study was to find out the prevalence of postoperative sore throat following general anaesthesia with endotracheal intubation in a tertiary care centre...
January 1, 2024: JNMA; Journal of the Nepal Medical Association
https://read.qxmd.com/read/38409357/tas2r38-haplotypes-covid-19-infection-and-symptomatology-a-cross-sectional-analysis-of-data-from-the-canadian-longitudinal-study-on-aging
#15
JOURNAL ARTICLE
Tongzhu Meng, Daiva E Nielsen
The TAS2R38 gene is well known for its function in bitter taste sensitivity, but evidence also suggests a role in innate immunity. TAS2R38 may be relevant in coronavirus disease 2019 (COVID-19), but research findings are inconsistent. The objective of this study was to explore whether common TAS2R38 haplotypes are associated with COVID-19 infection and symptomatology in the Canadian Longitudinal Study on Aging (CLSA). Data from the CLSA COVID-19 Questionnaire and Seroprevalence sub-studies were utilized with CLSA genetic data for common TAS2R38 haplotypes related to bitter taste sensitivity...
February 26, 2024: Scientific Reports
https://read.qxmd.com/read/38407717/epidemiological-and-clinical-characteristics-associated-with-covid-19-severity-among-hospitalized-patients-in-the-united-arab-emirates-a-retrospective-multicentre-study
#16
JOURNAL ARTICLE
Najlaa Al-Bluwi, Razan Agha, Ankita Shukla, Rouba Karen Zeidan, Hamzah AlZubaidi, Manal Awad, Amal Hussein, Muzan Abdelbagi, Khaled AlSayed, Mohamad B Alebaji, Mahasin Shaheen, Laila Salameh, Bassam Mahboub, Hady Elkhodary, Riyad Bendardaf, Ghada Mohammed, Dima Wardat, Zahraa Al-Hano, Hajir I Amara, Mohamed Saleh Alhajjaj, Qutayba Hamid, Rabih Halwani, Basema Saddik
OBJECTIVES: To investigate the clinical and epidemiological factors associated with severe COVID-19 cases in hospitalized patients across two emirates within the United Arab Emirates (UAE). METHODS: A retrospective observational analytical study analysed data from 738 medical records and conducted 573 in-depth interviews with patients hospitalized across multiple healthcare centers in the UAE, between 29 January 2020 and 14 October 2021. Regression analysis predicted risk factors for COVID-19 severity...
February 26, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38403360/-clinical-comprehensive-evaluation-of-houyanqing-oral-liquid-in-treatment-of-acute-pharyngitis
#17
JOURNAL ARTICLE
Jun-Yu Xi, Zhong-Yi Wei, Qiang Zhang, Yan-Ming Xie
This study systematically combed the existing evidence of Houyanqing Oral Liquid in the treatment of acute pharyngitis from the "6+1" dimensions of safety, effectiveness, economy, innovation, suitability, accessibility, and characteristics of traditional Chinese medicine(TCM) and carried out qualitative and quantitative analysis of the data from each dimension. The multi-criteria decision analysis(MCDA) model and CSC v2.0 were used to evaluate the clinical value of this drug, so as to provide evidence for the selection of essential drugs in the department of otolaryngology and for medical and health decision-making...
January 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38389521/evaluation-of-the-expression-of-infection-related-long-noncoding-rnas-among-covid-19-patients-a-case-control-study
#18
JOURNAL ARTICLE
Zahra Firoozi, Elham Mohammadisoleimani, Farzaneh Bagheri, Atefeh Taheri, Babak Pezeshki, Mohammad Mehdi Naghizadeh, Abdolreza Daraei, Jalal Karimi, Yousef Gholampour, Yaser Mansoori, Zahra Montaseri
BACKGROUND AND AIMS: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a worldwide pandemic, activates signaling cascades and leads to innate immune responses and secretion of multiple chemokines and cytokines. Long noncoding RNAs (lncRNAs) have a crucial role in inflammatory pathways. Through our search on the PubMed database, we discovered that existing research has primarily focused on examining the regulatory impacts of five lncRNAs in the context of viral infections. However, their role in regulating other conditions, including SARS-CoV-2, has not been explored...
2024: Genetics Research
https://read.qxmd.com/read/38377084/fusobacterium-necrophorum-intratonsillar-abscess-as-a-source-of-bacteremia-in-a-patient-with-a-history-of-substance-abuse
#19
JOURNAL ARTICLE
Claudiu Nanu, Liana Adela Ciocan, Georgiana Radu, Liliana Sumedrea, Gabriel Adrian Popescu, Alina Maria Borcan
A 22-year-old male, with a history of recreational drug use, was admitted with a 24-hour history of sore throat, bilateral otalgia, fever, chills, sweats, and pain in the upper chest. The blood cultures were positive for Fusobacterium necrophorum. A thoracic and neck soft tissue computed tomography (CT) scan revealed an intratonsillar abscess and pulmonary septic emboli. Initial treatment with Piperacillin-tazobactam and Clindamycin was de-escalated after 5 days. The patient made a complete recovery after 22 days of antibiotic treatment...
January 31, 2024: Journal of Infection in Developing Countries
https://read.qxmd.com/read/38376591/seawater-nasal-wash-to-reduce-symptom-duration-and-viral-load-in-covid-19-and-upper-respiratory-tract-infections-a-randomized-controlled-multicenter-trial
#20
JOURNAL ARTICLE
Ludovic de Gabory, Sophie Vallet, Gaëlle Naelten, Chantal Raherison-Semjen
PURPOSE: The objective was to assess the efficacy of seawater nasal wash on symptom duration, intranasal viral load, household transmission in COVID-19 and URTIs. METHODS: This prospective, randomized, controlled, multicentric, parallel study included 355 mild/moderate COVID-19 and URTI adults with rhinologic symptoms ≤ 48h. Active group performed 4-daily nasal washes with undiluted isotonic seawater versus control group (without nasal wash)...
February 20, 2024: European Archives of Oto-rhino-laryngology
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