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https://www.readbyqxmd.com/read/28238124/preliminary-genetic-evidence-of-two-different-populations-of-opisthorchis-viverrini-in-lao-pdr
#1
Opal Pitaksakulrat, Nadda Kiatsopit, Nonglak Laoprom, Bonnie L Webster, Joanne P Webster, Poppy H L Lamberton, Thewarach Laha, Ross H Andrews, Trevor N Petney, David Blair, Elizabeth J Carlton, Robert C Spear, Paiboon Sithithaworn
Opisthorchis viverrini is a major public health concern in Southeast Asia. Various reports have suggested that this parasite may represent a species complex, with genetic structure in the region perhaps being dictated by geographical factors and different species of intermediate hosts. We used four microsatellite loci to analyze O. viverrini adult worms originating from six species of cyprinid fish in Thailand and Lao PDR. Two distinct O. viverrini populations were observed. In Ban Phai, Thailand, only one subgroup occurred, hosted by two different fish species...
February 25, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28230448/opioid-use-for-pain-management-after-implementation-of-a-medicaid-short-acting-opioid-quantity-limit
#2
Catherine S Riggs, Sarah J Billups, Samantha Flores, Rachana J Patel, Rachel M F Heilmann, Jessica L Milchak
BACKGROUND: The United States is currently experiencing an opioid abuse epidemic. Many policies and programs have been implemented at local, state, and national levels in an attempt to decrease prescription opioid addiction and overdose. On August 1, 2014, Colorado Medicaid implemented a policy change that limited the quantity of short-acting opioids (SAOs) that could be filled through the Medicaid benefit to no more than 4 tablets per day, or 120 tablets in 30 days. OBJECTIVE: To compare mean total daily dose (TDD) of opioids purchased by Kaiser Permanente Colorado (KPCO) Medicaid patients before and after implementation of the Medicaid SAO quantity limit...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28227946/analysis-of-effective-sit-to-stand-therapy-using-kinematic-synergies
#3
Bryan Lao, Tomoya Tamei, Kazushi Ikeda, Bryan Lao, Tomoya Tamei, Kazushi Ikeda, Tomoya Tamei, Bryan Lao, Kazushi Ikeda
Understanding effective sit-to-stand (STS) movement is essential for improving rehabilitation strategies and developing services for the rapidly increasing number of elderly people. This study aims at identifying effective STS therapy by analyzing the kinematic synergies of movements induced by therapists of different skill-levels. Three synergies were found to share the same temporal pattern in both joint angles and center-of-mass spaces across all therapists. Effective strategy used by a skilled therapist and strategy flaws of less-experienced therapists were revealed through comparison of spatial patterns...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223800/comparison-of-the-cellular-transport-mechanism-of-cationic-star-shaped-polymers-and-liposomes-in-hacat-cells
#4
Heng-Cong Luo, Na Li, Li Yan, Kai-Jin Mai, Kan Sun, Wei Wang, Guo-Juan Lao, Chuan Yang, Li-Ming Zhang, Meng Ren
Several biological barriers must be overcome to achieve efficient nonviral gene delivery. These barriers include target cell uptake, lysosomal degradation, and dissociation from the carrier. In this study, we compared the differences in the uptake mechanism of cationic, star-shaped polymer/MMP-9siRNA complexes (β-CD-(D3)7/MMP-9siRNA complexes: polyplexes) and commercial liposome/MMP-9siRNA complexes (Lipofectamine(®) 2000/MMP-9siRNA complexes: liposomes). The uptake pathway and transfection efficiency of the polyplexes and liposomes were determined by fluorescence microscopy, flow cytometry, and reverse transcriptase-polymerase chain reaction...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28216369/role-of-socio-cultural-and-economic-factors-in-cyprinid-fish-distribution-networks-and-consumption-in-lawa-lake-region-northeast-thailand-novel-perspectives-on-opisthorchis-viverrini-transmission-dynamics
#5
Christina Sunyoung Kim, John F Smith, Apiporn Suwannatrai, Pierre Echaubard, Bruce Wilcox, Sasithorn Kaewkes, Paiboon Sithithaworn, Banchob Sripa
Opisthorchis viverrini (Ov) is a fish-borne parasite endemic in parts of Lao PDR, Cambodia, southern Vietnam and Northeast Thailand (Isaan) where an estimated 10 million people are infected. Human Ov infection, associated with hepatobiliary complications, including cholangiocarcinoma (CCA), occurs when infected fish are consumed raw or undercooked, a longstanding cultural tradition in the region. This mixed- methods descriptive study was carried out in Isaan villages around Lawa Lake, Khon Kaen Province, known for their Ov endemicity...
February 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28212409/pathogenic-waterborne-free-living-amoebae-an-update-from-selected-southeast-asian-countries
#6
Mohamad Azlan Abdul Majid, Tooba Mahboob, Brandon G J Mong, Narong Jaturas, Reena Leeba Richard, Tan Tian-Chye, Anusorn Phimphila, Panomphanh Mahaphonh, Kyaw Nyein Aye, Wai Lynn Aung, Joon Chuah, Alan D Ziegler, Atipat Yasiri, Nongyao Sawangjaroen, Yvonne A L Lim, Veeranoot Nissapatorn
Data on the distribution of free-living amoebae is still lacking especially in Southeast Asian region. The aquatic environment revealed a high occurrence of free-living amoebae (FLA) due to its suitable condition and availability of food source, which subsequently causes infection to humans. A total of 94 water samples consisted of both treated and untreated from Laos (31), Myanmar (42), and Singapore (21) were investigated for the presence of pathogenic FLA. Each water sample was filtered and cultured onto non-nutrient agar seeded with live suspension of Escherichia coli and incubated at room temperature...
2017: PloS One
https://www.readbyqxmd.com/read/28210541/a-t1-and-dti-fused-3d-corpus-callosum-analysis-in-mci-subjects-with-high-and-low-cardiovascular-risk-profile
#7
Yi Lao, Binh Nguyen, Sinchai Tsao, Niharika Gajawelli, Meng Law, Helena Chui, Michael Weiner, Yalin Wang, Natasha Leporé
Understanding the extent to which vascular disease and its risk factors are associated with prodromal dementia, notably Alzheimer's disease (AD), may enhance predictive accuracy as well as guide early interventions. One promising avenue to determine this relationship consists of looking for reliable and sensitive in-vivo imaging methods capable of characterizing the subtle brain alterations before the clinical manifestations. However, little is known from the imaging perspective about how risk factors such as vascular disease influence AD progression...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28206762/influence-of-lafeo3-surface-termination-on-water-reactivity
#8
Kelsey A Stoerzinger, Ryan B Comes, Steven R Spurgeon, Suntharampillai Thevuthasan, Kyuwook Ihm, Ethan J Crumlin, Scott A Chambers
The polarity of oxide surfaces can dramatically impact their surface reactivity, in particular with polar molecules such as water. The surface species that result from this interaction change the oxide electronic structure and chemical reactivity in applications such as photoelectrochemistry, but are challenging to probe experimentally. Here we report a detailed study of the surface chemistry and electronic structure of the perovskite LaFeO3 in humid conditions using ambient pressure X-ray photoelectron spectroscopy...
February 16, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28193719/brain-specific-ablation-of-efr3a-promotes-adult-hippocampal-neurogenesis-via-the-brain-derived-neurotrophic-factor-pathway
#9
Qi Qian, Qiuji Liu, Dongming Zhou, Hongyu Pan, Zhiwei Liu, Fangping He, Suying Ji, Dongpi Wang, Wangxiao Bao, Xinyi Liu, Zhaoling Liu, Heng Zhang, Xiaoqin Zhang, Ling Zhang, Mingkai Wang, Ying Xu, Fude Huang, Benyan Lao, Binggui Sun
Efr3 is a newly identified plasma membrane protein and plays an important role in the phosphoinositide metabolism on the plasma membrane. However, although it is highly expressed in the brain, the functional significance of Efr3 in the brain is not clear. In the present study, we generated Efr3a(f/f) mice and then crossed them with Nestin-Cre mice to delete Efr3a, one of the Efr3 isoforms, specifically in the brain. We found that brain-specific ablation of Efr3a promoted adult hippocampal neurogenesis by increasing survival and maturation of newborn neurons without affecting their dendritic tree morphology...
February 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28193684/an-agonist-of-the-protective-factor-sirt1-improves-functional-recovery-and-promotes-neuronal-survival-by-attenuating-inflammation-after-spinal-cord-injury
#10
Haihong Chen, Hao Ji, Ming Zhang, Zude Liu, Lifeng Lao, Chao Deng, Jianwei Chen, Guibin Zhong
Targeting posttraumatic inflammation is crucial for improving locomotor function. SIRT1 has been shown to play a critical role in disease processes such as hepatic inflammation, rheumatoid arthritis and acute lung inflammation by regulating inflammation. However, the role of SIRT1 in spinal cord injury (SCI) is unknown. We hypothesized that SIRT1 plays an important role in improving locomotor function after SCI by regulating neuroinflammation. In this study, we investigated the effect of SIRT1 in SCI using pharmacological intervention (SRT1720) and the Mx1-Cre/loxP recombination system to knock out target genes...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28187629/review-of-the-genus-i-lanchnophorus-i-hemiptera-heteroptera-rhyparochromidae-with-description-of-three-new-species-and-other-nomenclatural-changes
#11
Petr Kment, Attilio Carapezza, Zdeněk Jindra, Előd Kondorosy
The generic name Lanchnophorus Reuter, 1887, deemed for a long time to be unavailable as incorrect original spelling of Lachnophorus (in fact Lachnophorus Distant, 1903 is an unjustified emendation of the former), is restored as a valid name of the genus. Lachnesthus Bergroth, 1915, syn. nov. (new name for the preoccupied Lachnophorus Distant, 1903) is considered junior synonym of Lanchnophorus. The following nomenclatural changes are proposed: Lanchnophorus flavus (Scudder, 1971) comb. nov. = Lachnesthus chinai Scudder, nomen nudum; Lanchnophorus guttulatus Reuter, 1887, comb...
January 25, 2017: Zootaxa
https://www.readbyqxmd.com/read/28187539/a-revision-of-the-species-of-i-evaza-i-walker-described-by-j-c-h-de-meijere%C3%A2-diptera-stratiomyidae-pachygastrinae
#12
Rudolf Rozkošný, Jaromír Vaňhara
Six Oriental species of Evaza Walker, 1856 were described by J.C.H. de Meijere in the period between 1911 and 1924. The type specimens are now deposited in the Museum Naturalis (Leiden). All species were redescribed, photographed and their diagnostic characters were defined. Male terminalia of five species with known males were illustrated in detail. The revised species were compared with recently described new species from Oriental China. Additional material belonging to the revised species was recorded for the first time from the following countries: Evaza demeijerei Brunetti, 1923 (= E...
February 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28183300/an-investigation-of-stigmatizing-attitudes-towards-people-living-with-hiv-aids-by-doctors-and-nurses-in-vientiane-lao-pdr
#13
Savina Vorasane, Masamine Jimba, Kimiyo Kikuchi, Junko Yasuoka, Keiko Nanishi, Jo Durham, Vanphanom Sychareun
BACKGROUND: Despite global efforts, HIV-related stigma continues to negatively impact the health and well-being of people living with HIV/AIDS. Even in healthcare settings, people with HIV/AIDS experience discrimination. Anecdotal evidence suggests that healthcare professionals in the Lao People's Democratic Republic, a lower-middle income country situated in Southeast Asia, stigmatize HIV/AID patients. The purpose of this study was to assess HIV stigmatizing attitudes within Laotian healthcare service providers and examine some of the factors associated with HIV/AIDS-related stigma among doctors and nurses...
February 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28181687/acupuncture-for-acute-hordeolum
#14
REVIEW
Ke Cheng, Andrew Law, Menghu Guo, L Susan Wieland, Xueyong Shen, Lixing Lao
BACKGROUND: Hordeolum is an acute, purulent inflammation of the eyelid margin usually caused by obstructed orifices of the sebaceous glands of the eyelid. The condition, which affects sebaceous glands internally or externally, is common. When the meibomian gland in the tarsal plate is affected, internal hordeolum occurs, while when the glands of Zeis or Moll associated with eyelash follicles are affected, external hordeolum, or stye occurs. The onset of hordeolum is usually self limited, and may resolve in about a week with spontaneous drainage of the abscess...
February 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28181574/indispensable-role-of-mdm2-p53-interaction-during-the-embryonic-and-postnatal-inner-ear-development
#15
M Laos, M Sulg, A Herranen, T Anttonen, U Pirvola
p53 is a key component of a signaling network that protects cells against various stresses. As excess p53 is detrimental to cells, its levels are tightly controlled by several mechanisms. The E3 ubiquitin ligase Mdm2 is a major negative regulator of p53. The significance of balanced p53 levels in normal tissues, at different stages of lifetime, is poorly understood. We have studied in vivo how the disruption of Mdm2/p53 interaction affects the early-embryonic otic progenitor cells and their descendants, the auditory supporting cells and hair cells...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28179080/simultaneous-determination-of-13-carotenoids-by-a-simple-c18-column-based-ultra-high-pressure-liquid-chromatography-method-for-carotenoid-profiling-in-the-astaxanthin-accumulating-haematococcus-pluvialis
#16
Hui Jin, Yong Min Lao, Jin Zhou, Huai Jin Zhang, Zhong Hua Cai
A simple ultra-high-pressure liquid chromatography (UHPLC) method for rapidly and simultaneously identifying thirteen carotenoids in Haematococcus pluvialis was developed in this study. The method is capable of effectively separating two astaxanthin isomers, two ζ-carotene isomers, and three phytoene isomers on two simple C18 columns within 9 and 12min only by using methanol and acetonitrile, respectively. To our best knowledge, this is the rapidest method for these carotenoid isomers, currently. Using this method, carotenoid profiling in the astaxanthin-accumulating H...
March 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28177936/local-anodic-oxidation-on-hydrogen-intercalated-graphene-layers-oxide-composition-analysis-and-role-of-the-silicon-carbide-substrate
#17
Francesco Colangelo, Vincenzo Piazza, Camilla Coletti, Stefano Roddaro, Fabio Beltram, Pasqualantonio Pingue
We investigate nanoscale local anodic oxidation (LAO) on hydrogen-intercalated graphene grown by controlled sublimation of silicon carbide (SiC). Scanning probe microscopy was used as a lithographic and characterization tool in order to investigate the local properties of the nanofabricated structures. The anomalous thickness observed after the graphene oxidation process is linked to the impact of LAO on the substrate. Micro-Raman (μ-Raman) spectroscopy was employed to demonstrate the presence of two oxidation regimes depending on the applied bias...
March 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28170396/moxibustion-for-pain-relief-in-patients-with-primary-dysmenorrhea-a-randomized-controlled-trial
#18
Mingxiao Yang, Xiangzhu Chen, Linna Bo, Lixing Lao, Jiao Chen, Siyi Yu, Zheng Yu, Hongzhi Tang, Ling Yi, Xi Wu, Jie Yang, Fanrong Liang
BACKGROUND: Though moxibustion is frequently used to treat primary dysmenorrhea in China, relevant evidence supporting its effectiveness is still scanty. METHODS: This study was a pragmatic randomized, conventional drug controlled, open-labeled clinical trial. After initial screen, 152 eligible participants were averagely randomized to receive two different treatment strategies: Moxibustion and conventional drugs. Participants and practitioners were not blinded in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28169334/operator-radiation-and-the-efficacy-of-ceiling-suspended-lead-screen-shielding-during-coronary-angiography-an-anthropomorphic-phantom-study-using-real-time-dosimeters
#19
Qianjun Jia, Ziman Chen, Xianxian Jiang, Zhenjun Zhao, Meiping Huang, Jiahua Li, Jian Zhuang, Xiaoqing Liu, Tianyu Hu, Wensheng Liang
Operator radiation and the radiation protection efficacy of a ceiling-suspended lead screen were assessed during coronary angiography (CA) in a catheterization laboratory. An anthropomorphic phantom was placed under the X-ray beam to simulate patient attenuation in eight CA projections. Using real-time dosimeters, radiation dose rates were measured on models mimicking a primary operator (PO) and an assistant. Subsequently, a ceiling-suspended lead screen was placed in three commonly used positions to compare the radiation protection efficacy...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169274/armc5-deletion-causes-developmental-defects-and-compromises-t-cell-immune-responses
#20
Yan Hu, Linjiang Lao, Jianning Mao, Wei Jin, Hongyu Luo, Tania Charpentier, Shijie Qi, Junzheng Peng, Bing Hu, Mieczyslaw Martin Marcinkiewicz, Alain Lamarre, Jiangping Wu
Armadillo repeat containing 5 (ARMC5) is a cytosolic protein with no enzymatic activities. Little is known about its function and mechanisms of action, except that gene mutations are associated with risks of primary macronodular adrenal gland hyperplasia. Here we map Armc5 expression by in situ hybridization, and generate Armc5 knockout mice, which are small in body size. Armc5 knockout mice have compromised T-cell proliferation and differentiation into Th1 and Th17 cells, increased T-cell apoptosis, reduced severity of experimental autoimmune encephalitis, and defective immune responses to lymphocytic choriomeningitis virus infection...
February 7, 2017: Nature Communications
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