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Xiang Qian Lao, Han-Bing Deng, Xudong Liu, Ta-Chien Chan, Zilong Zhang, Ly-Yun Chang, Eng-Kiong Yeoh, Tony Tam, Martin Chi Sang Wong, G Neil Thomas
AIMS: To evaluate the effects of habitual leisure-time physical activity (LTPA) on incident type 2 diabetes in a prospective cohort of Chinese adults with impaired fasting glucose (IFG). METHODS: 44 828 Chinese adults aged 20-80 years with newly detected IFG but free from cardiovascular and cerebrovascular disease were recruited and followed up from 1996 to 2014. Incident type 2 diabetes was identified by fasting plasma glucose ≥7 mmol/L. The participants were classified into four categories based on their self-reported weekly LTPA: inactive, low, moderate, or high...
January 13, 2018: British Journal of Sports Medicine
Lao-Tzu Allan-Blitz, Peera Hemarajata, Romney M Humphries, Adriane Wynn, Eddy R Segura, Jeffrey D Klausner
BACKGROUND: Novel approaches to combating drug-resistant Neisseria gonorrhoeae infections are urgently needed. Targeted therapy with ciprofloxacin has been made possible by a rapid assay for genotyping the gyrase A (gyrA) gene; a nonmutated gene reliably predicts susceptibility to ciprofloxacin. METHODS: We determined the costs of running the gyrA assay, 500 mg of ciprofloxacin, 250 mg of ceftriaxone injection, and 1000 mg of azithromycin. Cost estimates for gyrA testing included assay reagents and labor...
February 2018: Sexually Transmitted Diseases
Linda Hadjadj, Tawisa Jiyipong, Fadi Bittar, Serge Morand, Jean-Marc Rolain
Bartonella tribocorum is a Gram-negative bacterium known to infect animals, and rodents in particular, throughout the world. In this report, we present the draft genome sequences of two strains of B. tribocorum isolated from the blood of a rodent in Laos and a shrew in Cambodia.
January 11, 2018: Genome Announcements
Suttipat Srisutham, Naowarat Saralamba, Kanlaya Sriprawat, Mayfong Mayxay, Frank Smithuis, Francois Nosten, Sasithon Pukrittayakamee, Nicholas P J Day, Arjen M Dondorp, Mallika Imwong
BACKGROUND: Genetic diversity of the three important antigenic proteins, namely thrombospondin-related anonymous protein (TRAP), apical membrane antigen 1 (AMA1), and 6-cysteine protein (P48/45), all of which are found in various developmental stages of Plasmodium parasites is crucial for targeted vaccine development. While studies related to the genetic diversity of these proteins are available for Plasmodium falciparum and Plasmodium vivax, barely enough information exists regarding Plasmodium malariae...
January 11, 2018: Malaria Journal
Chen Chen, Le Fang, Jihua Zhang, Guodong Zhao, Wei Ren
We explored the possibility of increasing the interfacial carrier quantum confinement, mobility and conductivity in the (LaAlO3)n/(BaTiO3)n superlattices by thickness regulation using the first-principles electronic structure calculations. Through constructing two different interfacial types of LaAlO3/BaTiO3 superlattices, we discovered that the LaO/TiO2 interface is preferred from cleavage energy consideration. We then studied the electronic characteristics of two-dimensional electron gas (2DEG) produced at the LaO/TiO2 interface in the LaAlO3/BaTiO3 superlattices via spin-polarized density functional theory calculations...
January 11, 2018: Scientific Reports
Alexander C Flint, Shiv G Bhandari, Sean P Cullen, Adhikari V Reddy, Daniel P Hsu, Vivek A Rao, Minal Patel, Jasmeen Pombra, Nancy J Edwards, Sheila L Chan
BACKGROUND AND PURPOSE: Large artery occlusion (LAO) in ischemic stroke requires recognition and triage to an endovascular stroke treatment center. Noninvasive LAO detection is needed to improve triage. METHODS: Prospective study to test whether noninvasive cerebral oximetry can detect anterior circulation LAO in acute stroke. Interhemispheric ΔBrSO2 in LAO was compared with controls. RESULTS: In LAO stroke, mean interhemispheric ΔBrSO2 was -8...
January 10, 2018: Stroke; a Journal of Cerebral Circulation
Bipin Adhikari, Koukeo Phommasone, Palingnaphone Kommarasy, Xayaphone Soundala, Phonesavanh Souvanthong, Tiengkham Pongvongsa, Gisela Henriques, Paul N Newton, Nicholas J White, Nicholas P J Day, Arjen M Dondorp, Lorenz von Seidlein, Mayfong Mayxay, Phaik Yeong Cheah, Christopher Pell
BACKGROUND: As a part of targeted malaria elimination (TME) in the Greater Mekong Sub-region (GMS), mass drug administration (MDA) with anti-malarials was conducted in four villages in Nong District, Savannakhet Province, Lao PDR (Laos). A high proportion of the target population participated in the MDA, with over 87% agreeing to take the anti-malarial. Drawing on qualitative data collected alongside the MDA, this article explores the factors that led to this high population coverage...
January 9, 2018: Malaria Journal
Noorazrul Yahya, Nurhaziqah Roslan
BACKGROUND AND PURPOSE: As about 50% of cancer patients may require radiotherapy, the demand of radiotherapy as the main treatment to treat cancer is likely to rise due to rising cancer incidence. This study aims to quantify the radiotherapy demand in countries in Southeast Asia (SEA) in 2025 and 2035 using evidence-based optimal radiotherapy fractions. MATERIALS AND METHODS: SEA country-specific cancer incidence by tumor site for 2015, 2025 and 2035 was extracted from the GLOBOCAN database...
January 8, 2018: Asia-Pacific Journal of Clinical Oncology
Marika Nomura, Phonepadith Xangsayarath, Kenzo Takahashi, Yusuke Kamiya, Latsamy Siengsounthone, Hina Ogino, Jun Kobayashi
BACKGROUND: The global coverage rate of birth registration is only around 65% for the population of children under five although birth registration secures protection and access to health services that are fundamental rights for all babies. This study aimed to perform a basic analysis of the accessibility to birth registration to better understand how to improve the birth registration system in the Lao PDR. METHODS: For the analysis of birth registration and related socioeconomic factors, 9576 mother-child pairs were chosen from the data set of The Lao Social Indicator Survey 2011-12...
January 8, 2018: BMC Public Health
Peibo Gao, Shixing Xu, Zhangwei Chen, Xi Huang, Zhihao Bao, Changshi Lao, Guangming Wu, Yongfeng Mei
Carbon hosts have been utilized to obtain composite cathodes with high sulfur loadings for Li-S battery. However the complicated synthesis process may hinder their practical applications. Besides, their mechanical and electrochemical properties shall be further improved. Herein, a facile scalable dip-coating process is developed to synthesize a flexible composite cathode with a high sulfur loading. Via the process, a hybrid composed of carbon nanotubes, carbon black, sulfur and titania nanoparticles is successfully conformally coated on the carbonized textile (c-textile)...
January 8, 2018: ACS Applied Materials & Interfaces
Naseer Ullah Khan, Hua He, Xiaojuan Wang, Baosheng Ge, Qian Wang, Xu Liu, Jun Lao, Yanan Wang, Jiqiang Li, Zhencai Wang, Shitan Zhou, Fang Huang
An ultra-high fluorescence enhancement for two dyes on photonic crystal films was achieved to construct a two-color immuno-dot blot assay. This assay was demonstrated to simultaneously detect chemokine receptor co-expressed in cancer cells and reveal their co-operative and subtle changes after binding with respective ligands and drugs.
January 8, 2018: Chemical Communications: Chem Comm
Anamai Thetkathuek, Wanlop Jaidee
BACKGROUND: There has been a strong increase in the international movement of workers during the last few decades. As Thailand's economy has rapidly developed during the past 20 years, it has attracted growing numbers of laborers from the bordering countries of Myanmar, Lao PDR, and Cambodia. Numbers of migrant workers in Thai agriculture have risen to the extent that the sector's continued growth has become increasingly dependent on migrant workers. OBJECTIVE: The purpose of this study was to explore the factors that contribute to the development of symptoms of insecticide poisoning among immigrant agricultural workers in the eastern region of Thailand...
January 8, 2018: International Journal of Occupational and Environmental Health
Hai-Peng Pan, Qun Lao, Zheng-Hua Fei, Li Yang, Hai-Chun Zhou, Can Lai
Chylothorax is a rare cause of pleural effusion in children, and it is usually difficult to identify the location of chyle leakage due to the small size of the thoracic duct in children. Herein we report an infant case with chylothorax whose leakage of the thoracic duct was successfully located by magnetic resonance lymphangiography (MRL) using pre-contrast MR cholangiopancreatography (MRCP) and gadodiamide-enhanced spectral presaturation inversion recovery (SPIR) T1-weighted imaging, which demonstrate the imaging method is easy and effective for detecting the focal disruption of the thoracic duct in children with chylothorax and younger than 8 months old...
December 30, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
Wing Lok Lam, Wing Fai Yeung, Mei Kuen Wong, Chi Wai Cheung, Karen Kar Loen Chan, Hextan Yuen Sheung Ngan, Carlos King Ho Wong, Hai Yong Chen, Lixing Lao
BACKGROUND: Postoperative pain is a major complaint following abdominal surgery for gynecological diseases. Effective postoperative pain control after abdominal surgery is particularly important for patient recovery, mobility, and satisfaction. Acupuncture has been commonly used for pain management. However, its efficacy in postoperative pain control is inconclusive and health economic evaluation is limited. METHODS: A randomized, sham-controlled, patient- and- assessor-blind trial is designed to evaluate the efficacy and safety of acupuncture in managing postoperative pain following abdominal surgery of gynecological diseases...
January 4, 2018: Trials
Bo Yi, Suizan Zhou, Ying Song, Enfu Chen, Xuyin Lao, Jian Cai, Carolyn M Greene, Luzhao Feng, Jiandong Zheng, Hongjie Yu, Hongjun Dong
OBJECTIVES: To evaluate a community-based intervention that leveraged the non-communicable disease management system to increase seasonal influenza vaccination coverage among older adults in Ningbo, China. METHODS: From October 2014 - March 2015, we piloted the following on one street in Ningbo, China: educating community healthcare workers (C-HCWs) about influenza and vaccination; requiring C-HCWs to recommend influenza vaccination to older adults during routine chronic disease follow-up; and opening 14 additional temporary vaccination clinics...
January 4, 2018: Human Vaccines & Immunotherapeutics
Vilada Chansamouth, Rose McGready, Danoy Chommanam, Soukanya Homsombath, Mayfong Mayxay, Paul N Newton
Laos has the highest maternal mortality ratio in mainland Southeast Asia but there has been little research conducted with pregnant women. We aim to discuss ethical challenges in enrolling pregnant women in research as a part of large pregnancy cohort study in Laos. From 2013 to 2015, a prospective cohort study was conducted with 1000 pregnant women in a rural area of Vientiane, Laos, to determine whether fevers were associated with maternal morbidity and small for gestational age. Incidence of fever was 10% and incidence of small for gestational age was 12%...
December 14, 2017: Reproductive Health
Yuzhou Liu, Le Wang, Jie Lao, Xin Zhao
The present study aimed to perform microRNA (miRNA/miR) expression profiling of the thalamus (T), the anterior cingulate (AC), the dorsal horn of the spinal cord (DHSC) and the blood (B) in post‑complete brachial plexus avulsion (CBPA) pain model, and analyze biological functions. Neuropathic pain was induced in Sprague‑Dawley rats by CBPA. Animal behavioral tests were performed to differentiate the pain and control groups. DHSC, T, AC and B tissues were collected from the two groups for miRNA array analysis...
December 19, 2017: International Journal of Molecular Medicine
Somphavanh Somlor, Khamsing Vongpayloth, Laure Diancourt, Philippe Buchy, Veasna Duong, Darouny Phonekeo, Pakapak Ketmayoon, Phengta Vongphrachanh, Paul T Brey, Valérie Caro, Yves Buisson, Marc Grandadam
In May 2012, the first authenticated cases of active chikungunya virus infection were detected in Champasak Province, Southern Laos. Analysis of series of human samples and mosquito specimens collected during the outbreak and over the year that followed the emergence enabled the drawing up of a map of the progression of CHIKV and the establishment of a full genetic characterization of the virus.
2017: PloS One
Liyan Lao, Siting Fan, Erwei Song
Tumor-associated macrophages (TAMs) are the most abundant inflammatory infiltrates in the tumor stroma. TAMs promote tumor growth by suppressing immunocompetent cells, including neovascularization and supporting cancer stem cells. In the chapter, we discuss recent efforts in reprogramming or inhibiting tumor-protecting properties of TAMs, and developing potential strategies to increase the efficacy of breast cancer treatment.
2017: Advances in Experimental Medicine and Biology
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