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https://www.readbyqxmd.com/read/28099433/defining-seropositivity-thresholds-for-use-in-trachoma-elimination-studies
#1
Stephanie J Migchelsen, Diana L Martin, Khamphoua Southisombath, Patrick Turyaguma, Anne Heggen, Peter Paul Rubangakene, Hassan Joof, Pateh Makalo, Gretchen Cooley, Sarah Gwyn, Anthony W Solomon, Martin J Holland, Paul Courtright, Rebecca Willis, Neal D E Alexander, David C W Mabey, Chrissy H Roberts
BACKGROUND: Efforts are underway to eliminate trachoma as a public health problem by 2020. Programmatic guidelines are based on clinical signs that correlate poorly with Chlamydia trachomatis (Ct) infection in post-treatment and low-endemicity settings. Age-specific seroprevalence of anti Ct Pgp3 antibodies has been proposed as an alternative indicator of the need for intervention. To standardise the use of these tools, it is necessary to develop an analytical approach that performs reproducibly both within and between studies...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28092818/heterostructured-znfe2o4-tio2-nanotube-arrays-with-remarkable-visible-light-photoelectrocatalytic-performance-and-stability
#2
Shan Xie, Ke Ouyang, Yueming Lao, Peihao He, Qun Wang
A series of heterostructured ZnFe2O4/TiO2-nanotube arrays (NTAs) with remarkable visible-light photoelectrocatalytic (PEC) activity were successfully prepared via a two-step process of anodization and impregnation, followed by annealing. The structure and morphology of the as-prepared ZnFe2O4/TiO2-NTAs samples, PEC degradation abilities and photoelectrochemical performances, as well as long-term stabilities toward degradation of methyl orange (MO) solution under visible-light irradiation were deeply investigated...
January 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28088334/subtype-identification-of-human-blastocystis-spp-isolated-from-lao-people-s-democratic-republic
#3
Oranuch Sanpool, Sakhone Laymanivong, Tongjit Thanchomnang, Rutchanee Rodpai, Lakkhana Sadaow, Issarapong Phosuk, Wanchai Maleewong, Pewpan M Intapan
Blastocystis sp. is the most common protist found in the intestinal tract of humans and animals. Blastocystis subtypes (STs) are classified based on the molecular phylogeny of the small subunit rRNA gene (SSU rDNA). At least 17 Blastocystis STs have been reported and, of these, STs 1-9 have been found in humans. This study revealed the presence of human Blastocystis STs in Lao People's Democratic Republic (Lao PDR). Fecal samples were collected from apparently healthy people from the central province of Khammouane and the southern province of Champasak...
January 11, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28074382/engaging-hmong-adults-in-genomic%C3%A2-and%C3%A2-pharmacogenomic-research-toward-reducing-health-disparities-in-genomic-knowledge-using-a-community-based-participatory-research-approach
#4
Kathleen A Culhane-Pera, Robert J Straka, MaiKia Moua, Youssef Roman, Pachia Vue, Kang Xiaaj, May Xia Lo, Mai Lor
Advancing precision medicine relies in part on examining populations that may exhibit unique genetic variants that impact clinical outcomes. Failure to include diverse populations in genomic-based research represents a health disparity. We implemented a community-based participatory research (CBPR) process with the Hmong community in Minnesota, who were refugees from Laos, in order to assess the feasibility of conducting genomic and pharmacogenomic-based research for genetic variants that are relevant to the Hmong community...
January 10, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28067208/electronic-properties-of-laalo3-srtio3-n-type-interfaces-a-gga-u-study
#5
Irina Piyanzina, Thilo Kopp, Yury Lysogorskiy, Dmitrii Tayurskii, Volker Eyert
The role of electronic correlation effects for a realistic description of the electronic properties of LaAlO3/SrTiO3 heterostructures as covered by the on-site Coulomb repulsion within the GGA+U approach is investigated. Performing a systematic variation of the values of the Coulomb parameters applied to the Ti 3d and La 4f orbitals we put previous suggestions to include a large value for the La 4f states into perspective. Furthermore, our calculations provide deeper insight into the band gap landscape in the space spanned by these Coulomb parameters and the resulting complex interference effects...
January 9, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28060810/whole-genome-sequence-analysis-of-salmonella-typhi-isolated-in-thailand-before-and-after-the-introduction-of-a-national-immunization-program
#6
Zoe A Dyson, Duy Pham Thanh, Ladaporn Bodhidatta, Carl Jeffries Mason, Apichai Srijan, Maia A Rabaa, Phat Voong Vinh, Tuyen Ha Thanh, Guy E Thwaites, Stephen Baker, Kathryn E Holt
Vaccines against Salmonella Typhi, the causative agent of typhoid fever, are commonly used by travellers, however, there are few examples of national immunization programs in endemic areas. There is therefore a paucity of data on the impact of typhoid immunization programs on localised populations of S. Typhi. Here we have used whole genome sequencing (WGS) to characterise 44 historical bacterial isolates collected before and after a national typhoid immunization program that was implemented in Thailand in 1977 in response to a large outbreak; the program was highly effective in reducing typhoid case numbers...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28059508/non-classical-size-dependence-of-permeation-defines-bounds-for-passive-adsorption-of-large-drug-molecules
#7
Cameron R Pye, William M Hewitt, Joshua A Schwochert, Terra D Haddad, Chad E Townsend, Lyns Etienne, Yongtong Lao, Chris Limberakis, Akihiro Furukawa, Alan M Mathiowetz, David A Price, Spiros Liras, R Scott Lokey
There is a growing number of intracellular protein-protein interactions (PPI's) with potential therapeutic importance that demand larger ligands than those that neatly fit into most common criteria for "drug-likeness". Macrocyclic peptides pro-vide the large surface area required to inhibit PPIs and, in principle, avoid many of the pitfalls associated with peptides, including low stability and membrane permeability. However, the design of passively cell-permeable molecules in this space remains a great challenge due to the poorly understood roles of molecular size and lipophilicity in determining pas-sive membrane permeability above MW ~500...
January 6, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28059318/first-principles-prediction-of-a-rising-star-of-solar-energy-material-srtco-sub-3-sub
#8
Da Chen, Chun-Lan Ma, Gao-Yuan Chen, Cheng-Min Dai, Ling-Jun Gu, Li-Juan Ge, San-Huang Ke, Rong Wu
SrTcO<sub>3</sub> as a new star of solar energy material is investigated in terms of its band gap evolution with biaxial strain from first-principles calculations. Compared to the theoretical equilibrium lattice constant a(b) of bulk SrTcO<sub>3</sub>, a set of lattice constants with a deviation of -8.75% to +3.35% are considered to include the strain effect. Since the in-plane lattice constant of SrTcO<sub>3</sub> is larger than that of the commonly used substrate SrTiO<sub>3</sub>(STO)/La<sub>0...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28059040/natural-products-targeting-egfr-signaling-pathways-as-potential-anticancer-drugs
#9
Xiaoyu Wang, Linfeng Xu, Yuanzhi Lao, Hongmei Zhang, Hongxi Xu
The epidermal growth factor receptor (EGFR) belongs to ErbB family of tyrosine kinases, which plays an important role in the regulation of cell proliferation, survival, differentiation, and metastasis. In addition, tumors develop resistance to EGFR inhibitors due to the presence or development of point mutations in the tyrosine kinase domain of the receptor. There is an urgent need to develop new anti-EGFR agents with strong therapeutic activities. As the majority of anticancer drugs are of natural origin, natural products are a valuable source for the identification and development of novel treatment options for cancer...
January 5, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28053654/comparison-of-chemical-profiles-and-effectiveness-between-erxian-decoction-and-mixtures-of-decoctions-of-its-individual-herbs-a-novel-approach-for-identification-of-the-standard-chemicals
#10
H P Cheung, S W Wang, T B Ng, Y B Zhang, L X Lao, Z J Zhang, Y Tong, F W S Chung, S C W Sze
BACKGROUND: Identification of bioactive standard chemicals is a major challenge in the study of the Chinese medicinal formula. In particular, the chemical components may interact differently depending on the preparative methods, therefore affecting the amounts of bioactive components and their pharmacological properties in the medicinal formula. With the use of Erxian decoction (EXD) as a study model-a  well-known Chinese medicinal formula for treating menopausal symptoms, a novel and rapid approach in seeking standard chemicals has been established by differentially comparing the HPLC profiles and the menopause-related biochemical parameters of combined decoction of EXD (EXD-C) and mixtures of the decoctions of its individual herbs (EXD-S)...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28053307/asymmetric-interaction-of-point-defects-and-heterophase-interfaces-in-zrn-tan-multilayered-nanofilms
#11
Yuanxia Lao, Shuanglin Hu, Yunlong Shi, Yu Deng, Fei Wang, Hao Du, Haibing Zhang, Yuan Wang
Materials with a high density of heterophase interfaces, which are capable of absorbing and annihilating radiation-induced point defects, can exhibit a superior radiation tolerance. In this paper, we investigated the interaction behaviors of point defects and heterophase interfaces by implanting helium atoms into the ZrN/TaN multilayered nanofilms. It was found that the point defect-interface interaction on the two sides of the ZrN/TaN interface was asymmetric, likely due to the difference in the vacancy formation energies of ZrN and TaN...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28049846/sir2-suppresses-replication-gaps-and-genome-instability-by-balancing-replication-between-repetitive-and-unique-sequences
#12
Eric J Foss, Uyen Lao, Emily Dalrymple, Robin L Adrianse, Taylor Loe, Antonio Bedalov
Replication gaps that persist into mitosis likely represent important threats to genome stability, but experimental identification of these gaps has proved challenging. We have developed a technique that allows us to explore the dynamics by which genome replication is completed before mitosis. Using this approach, we demonstrate that excessive allocation of replication resources to origins within repetitive regions, induced by SIR2 deletion, leads to persistent replication gaps and genome instability. Conversely, the weakening of replication origins in repetitive regions suppresses these gaps...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28048039/su-f-i-74-dose-evaluation-based-on-monte-carlo-simulation-of-three-dimensional-rotational-angiography-during-hepatic-transarterial-chemoembolization-procedures
#13
Y Hwang, K Lui, Y Lin, H Tsai
PURPOSE: This study was aimed to investigate the dose with patient performing three-dimensional (3D) angiography imaging during hepatic transarterial chemoembolization (TACE) procedures. METHODS: Organ doses and effective doses calculations were retrospectively performed in 88 patients (61 males and 27 females with averaged age of 65.4±12.6 years old) referred for hepatic TACE on a digital flat-panel angiography system (Bransist safire; Shimadzu) using software (PCXMC; Helsinki, Finland) based on Monte Carlo technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047313/su-f-t-197-investigating-optimal-oblique-beam-arrangement-for-bilateral-metallic-prosthesis-prostate-cancer-in-pencil-beam-scanning-proton-therapy
#14
S Rana, Y Zheng, C Cheng, H Singh, T Twyford, B Tesfamicael, S Park
PURPOSE: The main purpose of this study is to investigate the optimum oblique-beam arrangement for bilateral metallic prosthesis prostate cancer treatment in pencil beam scanning (PBS) proton therapy. METHODS: A computed tomography dataset of bilateral metallic prosthesis prostate cancer case was selected for this retrospective study. A total of four beams (rightanterior- oblique [RAO], left-anterior-oblique [LAO], left-posterior-oblique [LPO], and right-posterior-oblique [RPO]) were selected for treatment planning...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047269/tu-h-campus-iep1-04-combined-organ-dose-for-digital-subtraction-angiography-and-computed-tomography-using-monte-carlo-simulation
#15
D Sakabe, T Ohno, F Araki, M Hashida, Y Funama
PURPOSE: The purpose of this study was to evaluate the combined organ dose of digital subtraction angiography (DSA) and computed tomography (CT) using a Monte Carlo (MC) simulation on the abdominal intervention. METHODS: The organ doses for DSA and CT were obtained with MC simulation and actual measurements using fluorescent-glass dosimeters at 7 abdominal portions in an Alderson-Rando phantom. DSA was performed from three directions: posterior anterior (PA), right anterior oblique (RAO), and left anterior oblique (LAO)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042405/imported-case-of-melioidosis-in-oman-case-report
#16
Nada Al Tamtami, Faryal Khamis, Amina Al-Jardani
Melioidosis is an infectious disease caused by the bacterium Burkholderia pseudomallei. It is most commonly described in Southeast Asia and Northern Australia and some imported cases in non-endemic areas. We describe the case of a 55-year-old Omani man with fulminant sepsis who worked in Laos, Cambodia. B. pseudomallei was isolated from the patient's blood and was identified by means of microbiological and biochemical tests. We highlight the importance of careful attention to non-fermentative gram-negative rods in a septic patients who have worked or travelled to Southeast Asia...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28034887/implementation-of-a-rapid-genotypic-assay-to-promote-targeted-ciprofloxacin-therapy-of-neisseria-gonorrhoeae-in-a-large-health-system
#17
Lao-Tzu Allan-Blitz, Romney M Humphries, Peera Hemarajata, Ashima Bhatti, Mark W Pandori, Mark J Siedner, Jeffrey D Klausner
Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.
December 28, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28011659/measuring-health-literacy-in-university-students-in-vientiane-lao-pdr
#18
Laina Runk, Jo Durham, Viengnakhone Vongxay, Vanphanom Sychareun
Health literacy includes the knowledge, motivation and competence of a person to make judgments and decisions on health information in order to promote and maintain their health in relation to health care, disease prevention and health promotion. The role health literacy plays in determining health outcomes makes it an important focus of public health research. In line with a larger Asia wide initiative (HLS-Asia), this study set out to measure health literacy in the Lao People's Democratic Republic (Lao-PDR)...
December 23, 2016: Health Promotion International
https://www.readbyqxmd.com/read/28008935/corrigendum-uplc-pda-qtofms-guided-isolation-of-prenylated-xanthones-and-benzoylphloroglucinols-from-the-leaves-of-garcinia-oblongifolia-and-their-migration-inhibitory-activity
#19
Hong Zhang, Dan Zheng, Zhi-Jie Ding, Yuan-Zhi Lao, Hong-Sheng Tan, Hong-Xi Xu
No abstract text is available yet for this article.
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000971/safety-and-tolerability-of-sonovue%C3%A2-in-patients-with-large-artery-anterior-circulation-acute-stroke
#20
Claudio Baracchini, Federica Viaro, Silvia Favaretto, Anna Palmieri, Caterina Kulyk, Francesco Causin, Filippo Farina, Enzo Ballotta
BACKGROUND AND PURPOSE: Ultrasound contrast agents (UCAs) are routinely used to improve the visualization of intracranial arteries. Since a higher rate of intracranial hemorrhage (ICH) has been observed in patients undergoing sonothrombolysis in combination with UCAs, we conducted this study with the aim of assessing safety and tolerability of SonoVue® in patients with acute ischemic stroke due to anterior circulation large artery occlusion (LAO) and eligible to intravenous thrombolysis and/or mechanical thrombectomy...
December 21, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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