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https://www.readbyqxmd.com/read/28651159/health-related-quality-of-life-results-from-the-phase-iii-checkmate-067-study
#1
Dirk Schadendorf, James Larkin, Jedd Wolchok, F Stephen Hodi, Vanna Chiarion-Sileni, Rene Gonzalez, Piotr Rutkowski, Jean-Jacques Grob, C Lance Cowey, Christopher Lao, John Wagstaff, Margaret K Callahan, Michael A Postow, Michael Smylie, Pier Francesco Ferrucci, Reinhard Dummer, Andrew Hill, Fiona Taylor, Javier Sabater, Dana Walker, Srividya Kotapati, Amy Abernethy, Georgina V Long
BACKGROUND: Nivolumab, a monoclonal antibody of immune checkpoint programmed death 1 on T cells (PD-1), combined with ipilimumab, an immune checkpoint cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor, as combination therapy on the one hand and nivolumab as monotherapy on the other, have both demonstrated improved efficacy compared with ipilimumab alone in the CheckMate 067 study. However, the combination resulted in a higher frequency of grade 3/4 adverse events (AEs), which could result in diminished health-related quality of life (HRQoL)...
June 22, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28649491/ventricular-shape-and-relative-position-abnormalities-in-preterm-neonates
#2
N Paquette, J Shi, Y Wang, Y Lao, R Ceschin, M D Nelson, A Panigrahy, N Lepore
Recent neuroimaging findings have highlighted the impact of premature birth on subcortical development and morphological changes in the deep grey nuclei and ventricular system. To help characterize subcortical microstructural changes in preterm neonates, we recently implemented a multivariate tensor-based method (mTBM). This method allows to precisely measure local surface deformation of brain structures in infants. Here, we investigated ventricular abnormalities and their spatial relationships with surrounding subcortical structures in preterm neonates...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28648850/complete-genome-analysis-of-dengue-virus-type-3-isolated-from-the-2013-dengue-outbreak-in-yunnan-china
#3
Xiaodan Wang, Dehong Ma, Xinwei Huang, Lihua Li, Duo Li, Yujiao Zhao, Lijuan Qiu, Yue Pan, Junying Chen, Juemin Xi, Xiyun Shan, Qiangming Sun
In the past few decades, dengue has spread rapidly and is an emerging disease in China. An unexpected dengue outbreak occurred in Xishuangbanna, Yunnan, China, resulting in 1331 patients in 2013. In order to obtain the complete genome information and perform mutation and evolutionary analysis of causative agent related to this largest outbreak of dengue fever. The viruses were isolated by cell culture and evaluated by genome sequence analysis. Phylogenetic trees were then constructed by Neighbor-Joining methods (MEGA6...
June 22, 2017: Virus Research
https://www.readbyqxmd.com/read/28646783/heart-rate-variability-in-patients-with-major-depression-disorder-during-a-clinical-autonomic-test
#4
Xiuwen Chen, Rongqian Yang, Danni Kuang, Lei Zhang, Ruixue Lv, Xiong Huang, Fengchun Wu, Guohui Lao, Shanxing Ou
Major depression disorder (MDD) patients express dysfunction autonomic nervous system (ANS) and reduced heart rate variability (HRV). However, previous researches mainly focused on examining resting state without considering a series of stimulation tests of ANS between MDD patients and healthy people. For this purpose, 40 healthy people and 40 MDD patients participated and finished 10min clinical autonomic test-Ewing test. Parameters of HRV such as time domain, frequency domain, and nonlinear dynamical parameters were calculated...
June 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28644895/floristic-characteristics-and-affinities-in-lao-pdr-with-a-reference-to-the-biogeography-of-the-indochina-peninsula
#5
Hua Zhu
The flora of Laos is composed of 5,005 species in 1,373 genera and 188 families of seed plants. Floristic and geographical attributes of the flora were analyzed. Tropical floristic elements at the family and generic levels contributed a majority (62.23% of the families and 82.30% of the genera) of the flora, of which the dominant geographical elements were pantropical distribution (42.02% of families) and tropical Asian distribution (30.08% of genera). This revealed that the flora of Lao PDR is tropical in nature and has a conspicuously tropical Asian affinity...
2017: PloS One
https://www.readbyqxmd.com/read/28639097/effect-of-an-internet-based-telehealth-system-on-functional-capacity-and-cognition-in-breast-cancer-survivors-a-secondary-analysis-of-a-randomized-controlled-trial
#6
Noelia Galiano-Castillo, Manuel Arroyo-Morales, Mario Lozano-Lozano, Carolina Fernández-Lao, Lydia Martín-Martín, Rosario Del-Moral-Ávila, Irene Cantarero-Villanueva
PURPOSE: This trial determines the effect of an Internet-based tailored exercise program compared to usual care control for improving functional capacity and cognition among breast cancer survivors. METHODS: A two-arm, assessor-blinded, parallel, randomized controlled efficacy trial was conducted. Participants were recruited from the Oncology and Breast unit at the Virgen de las Nieves Hospital (Granada, Spain) between March 2012 to November 2013 and randomized to either the experimental group (an 8-week Internet-based tailored exercise program) or control group (usual care)...
June 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28638220/green-tea-polyphenols-ameliorate-non-alcoholic-fatty-liver-disease-through-upregulating-ampk-activation-in-high-fat-fed-zucker-fatty-rats
#7
Yi Tan, Jane Kim, Jing Cheng, Madeleine Ong, Wei-Guo Lao, Xing-Liang Jin, Yi-Guang Lin, Linda Xiao, Xue-Qiong Zhu, Xian-Qin Qu
AIM: To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS: Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), inflammatory cytokines and hepatic triglyceride and liver histology...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28638092/from-shifting-cultivation-to-teak-plantation-effect-on-overland-flow-and-sediment-yield-in-a-montane-tropical-catchment
#8
Olivier Ribolzi, Olivier Evrard, Sylvain Huon, Anneke de Rouw, Norbert Silvera, Keo Oudone Latsachack, Bounsamai Soulileuth, Irène Lefèvre, Alain Pierret, Guillaume Lacombe, Oloth Sengtaheuanghoung, Christian Valentin
Soil erosion supplies large quantities of sediments to rivers of Southeastern Asia. It reduces soil fertility of agro-ecosystems located on hillslopes, and it degrades, downstream, water resource quality and leads to the siltation of reservoirs. An increase in the surface area covered with commercial perennial monocultures such as teak plantations is currently observed at the expanse of traditional slash-and-burn cultivation systems in steep montane environments of these regions. The impacts of land-use change on the hydrological response and sediment yields have been investigated in a representative catchment of Laos monitored for 13 years...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628113/microrna-20a-mediated-loss-of-autophagy-contributes-to-breast-tumorigenesis-by-promoting-genomic-damage-and-instability
#9
L Liu, J He, X Wei, G Wan, Y Lao, W Xu, Z Li, H Hu, Z Hu, X Luo, J Wu, W Xie, Y Zhang, N Xu
Gene expression analysis of The Cancer Genome Atlas (TCGA) breast cancer data set show that miR-20a is upregulated in human breast cancer, especially in triple-negative subtype. Gene Set Enrichment Analysis suggests that miR-20a expression negatively correlates with the autophagy/lysosome pathway. We report here that miR-20a inhibits the basal and nutrient starvation-induced autophagic flux and lysosomal proteolytic activity, increases intracellular reactive oxygen species levels and DNA damage response by targeting several key regulators of autophagy, including BECN1, ATG16L1 and SQSTM1...
June 19, 2017: Oncogene
https://www.readbyqxmd.com/read/28626259/lao-language-version-of-the-revised-hasegawa-s-dementia-scale
#10
Sengchanh Kounnavong, Khouanchay Soundavong, Syda Xayavong, Nialoun Vongpraserth, Phongsavang Bounsavath, Souphatsone Houatthongkham, Bounfeng Phoummalaysith, Yu Mon Saw, Eiko Yamamoto, Kenji Toba, Nobuyuki Hamajima
With the aging of society, the number of elderly with reduced cognitive function has been increasing worldwide. As a test to measure the cognitive function, the Revised Hasegawa's Dementia Scale (HDS-R) has been used in Japan, Korea, and China. Since there was no HDS-R version for Laotians, the questionnaire and manual were developed through the cooperation of Lao and Japanese researchers. Back-translation was conducted to confirm the accuracy of the translation. The score on the 9-item HDS-R ranges 0 to 30 points, and reduced cognitive function is usually defined as a score of 20 points or lower...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28626255/underlying-cause-of-death-recorded-during-2013-to-2015-at-a-tertiary-general-hospital-in-vientiane-capital-lao-pdr
#11
Bounfeng Phoummalaysith, Viengsakhone Louangpradith, Tavanh Manivon, Bounxou Keohavong, Eiko Yamamoto, Nobuyuki Hamajima
In Lao People's Democratic Republic (Lao PDR), the cause of death is not registered in death reports. As a result, the government cannot produce official reports that show mortality according to cause of death. This study aimed to report the underlying cause of death in a tertiary general hospital (Mittaphab Hospital) in Vientiane capital. Mittaphab hospital is a governmental teaching hospital with 300 beds for inpatient services specialized in orthopedics, neurology, and hemodialysis. Since a children hospital exists beside Mittaphab Hospital, severe pediatric cases are referred to the child hospital...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28626249/knowledge-of-free-delivery-policy-among-women-who-delivered-at-health-facilities-in-oudomxay-province-lao-pdr
#12
Tengbriacheu Chankham, Eiko Yamamoto, Joshua A Reyer, Rahman Arafat, Innoukham Khonemany, Sayamoungkhoun Panome, Dalavong Hongkham, Phommalaysith Bounfeng, Xeuthvongsa Anonh, Nobuyuki Hamajima
To promote the utilization of maternal health services and reduce financial barriers, the Laos government introduced its "Free Maternal Health Services Policy" in 2012. This policy provides free maternal health services for pregnant women, which includes costs related to treatment, transportation, food fees, referral and an incentive for four antenatal care appointments. This study aims to ascertain the knowledge level regarding this policy among Lao women and determine their level of satisfaction with the maternal service provision...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28619600/corrigendum-to-assessment-of-immunotoxicity-of-dibutyl-phthalate-using-live-zebrafish-fish-shellfish-immunology-fish-shellfish-immunol-45-2-2015-286-292
#13
Hai Xu, Xing Dong, Zhen Zhang, Xiangyang Wu, Hongcui Liu, Qiaocong Lao, Chunqi Li
No abstract text is available yet for this article.
June 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28612856/high-throughput-in-vitro-and-in-vivo-screening-of-inland-waters-of-southern-california
#14
A C Mehinto, D R VanDervort, W Lao, G He, M S Denison, S M Vliet, D C Volz, R D Mazor, K A Maruya
The impact of unmonitored contaminants, also known as contaminants of emerging concern (CECs), on freshwater streams remains largely uncharacterized. Water samples from 31 streams representing urban, agricultural and undeveloped (i.e., open space) land use in Southern California (USA) were analyzed for in vitro and in vivo bioactivity. The extent and magnitude of bioactivity screened using endocrine-responsive cell bioassays and a fish embryo screening assay were low. In contrast, a wider gradient of responses for the aryl hydrocarbon receptor (AhR) assay was observed, which was negatively correlated with a measure of benthic community structure...
June 14, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28610387/vietelmis-jablonskii-a%C3%A2-new-species-of-riffle-beetle-from-laos-and-thailand-and-new-faunistic-records-on-vietelmis-del%C3%A3-ve-1968-from-malaysia-coleoptera-elmidae
#15
Ján Kodada, Narumon Sangpradub, Rungnapa Somnark, Daniel Gruľa, Dávid Žiak, Hendrik Freitag
A new species of riffle beetle, Vietelmis jablonskii, from Laos and Thailand is described and illustrated. Differences to other Vietelmis species are discussed and an identification key for the Vietelmis is presented. New faunistic records are provided for V. kovaci Kodada & Čiampor, 2000; the genus Vietelmis is newly recorded for Thailand.
May 15, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610376/descriptions-of-two-new-species-of-torodorinae-lepidoptera-lecithoceridae-with-three-new-records-of-torodora-meyrick-from-laos
#16
Kyu-Tek Park, Yang-Seop Bae
Two new species of Torodorinae: Caveana plenalinea Park, sp. nov. and Antiochtha hemitatos Park, sp. nov., are described from Laos. At the same time, three species of the genus Torodora are reported for the first time from Laos.
May 16, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610346/a-description-of-three-new-species-of-the-genus-alienia-fibiger-2011-from-southeast-asia-lepidoptera-erebidae-hypenodinae-micronoctuini
#17
Mu-Jie Qi, Hui-Lin Han
The genus Alienia Fibiger, 2011 of the tribe Micronoctuini of Hypenodinae is revised. Two new species: Alienia fibigeri sp.n. and Alienia cambodiaa sp.n. are described from Cambodia; a new species, Alienia laosa sp.n. from Laos described. A key for identification of Alienia based on male genitalia is present. The adult and genitalia of the new species are illustrated.
May 19, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610338/revision-of-the-genus-doryscus-jacoby-coleoptera-chrysomelidae-galerucinae
#18
Chi-Feng Lee
The genus Doryscus Jacoby, 1887 is revised. Twelve new species are described: D. indochinensis sp. nov. from China (Yunnan), India, Laos, Thailand, Vietnam; D. krausi sp. nov. from Laos and Thailand; D. kubani sp. nov., from China (Yunnan); D. geiseri sp. nov. from Singapore and Thailand; D. nepalensis sp. nov. from Bhutan, north India, and Nepal; D. luzonensis sp. nov., and D. mindanaoensis sp. nov. from Philippines; D. barclayi sp. nov., D. boreri sp. nov., D. javanensis sp. nov., and D. sumatrensis sp. nov...
May 19, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610274/tadpole-of-the-critically-endangered-sterling-s-toothed-toad-i-oreolalax-sterlingae-i
#19
Jodi J L Rowley, Benjamin Tapley, Nguyen Thanh Chung, Ronald Altig
Sterling's Toothed Toad, Oreolalax sterlingae (Nguyen et al. 2013), was described from near the summit of the highest peak in Vietnam, Mount Fansipan, Lao Cai Province. The species is the only member of the genus in Vietnam and is presently known from a single stream system on Mount Fansipan at about 2800 m elevation. The closest congener occurs more than 200 km away in China (Fei et al. 2010), and the relationship of O. sterlingae within the genus is not known. Because of its extremely small range and profound habitat modifications and pollution at the site, O...
May 31, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610190/-i-pseudoleptonema-i-i-tansoongnerni-i-new-species-hydropsychidae-trichoptera-with-species-list-of-trichoptera-from-li-phi-falls-mekong-river-southern-laos
#20
Pongsak Laudee, Hans Malicky
A new species named Pseudoleptonema tansoongnerni n. sp. is presented along with a list of Trichoptera from Li Phi falls, Mekong River, southern Laos. Pseudoleptonema tansoongnerni n. sp. is described and figured based on adult males and females. It is distinguished from the others by its forewing pattern and color, which is yellowish brown.
March 10, 2017: Zootaxa
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