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https://www.readbyqxmd.com/read/29785142/misoprostol-for-the-prevention-of-postpartum-hemorrhage-during-home-births-in-rural-lao-pdr-establishing-a-pilot-program-for-community-distribution
#1
Jo Durham, Alongkone Phengsavanh, Vanphanom Sychareun, Isaac Hose, Viengnakhone Vongxay, Douangphachanh Xaysomphou, Keith Rickart
Purpose: The purpose of this study was to gather the necessary data to support the design and implementation of a pilot program for women who are unable to deliver in a healthcare facility in the Lao People's Democratic Republic (PDR), by using community distribution of misoprostol to prevent postpartum hemorrhage (PPH). The study builds on an earlier research that demonstrated both support and need for community-based distribution of misoprostol in Lao PDR. Methods: This qualitative study identified acceptability of misoprostol and healthcare system needs at varying levels to effectively distribute misoprostol to women with limited access to facility-based birthing...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29781615/superconductivity-of-rocksalt-structure-lao-epitaxial-thin-film
#2
Kenichi Kaminaga, Daichi Oka, Tetsuya Hasegawa, Tomoteru Fukumura
We report superconducting transition in LaO epitaxial thin film with the onset of superconducting transition temperature ( Tc ) at around 5 K. The Tc is the highest among lanthanum monochalcogenides opposite to the chemical trend of their Tc : 0.84, 1.02, and 1.48 K for La X ( X = S, Se, Te), respectively. The carrier control resulted in a dome-shaped Tc as a function of electron carrier density. In addition, the Tc was significantly sensitive to epitaxial strain in spite of its highly symmetric crystal structure...
May 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29780189/nonlinear-viscoelastic-characterization-of-human-vocal-fold-tissues-under-large-amplitude-oscillatory-shear-laos
#3
Roger W Chan
Viscoelastic shear properties of human vocal fold tissues were previously quantified by the shear moduli ( G' and G″ ). Yet these small-strain linear measures were unable to describe any nonlinear tissue behavior. This study attempted to characterize the nonlinear viscoelastic response of the vocal fold lamina propria under large-amplitude oscillatory shear (LAOS) with a stress decomposition approach. Human vocal fold cover and vocal ligament specimens from eight subjects were subjected to LAOS rheometric testing with a simple-shear rheometer...
May 2018: Journal of Rheology
https://www.readbyqxmd.com/read/29778319/anti-infective-biomaterials-with-surface-decorated-tachyplesin-i
#4
Qiong Xue, Xiao-Bin Liu, Yeh-Hsing Lao, Lin-Ping Wu, Dong Wang, Zhen-Qiang Zuo, Jun-Yu Chen, Jing Hou, Yuan-Yuan Bei, Xue-Fei Wu, Kam W Leong, Hua Xiang, Jing Han
Implants decorated with antimicrobial peptides (AMPs) can prevent infection and reduce the risk of creating antibiotic resistance. Yet the restricted mobility of surficial AMP often compromises its activity. Here, we report a simple but effective strategy to allow a more flexible display of AMP on the biomaterial surface and demonstrate its efficacy for wound healing. The AMP, tachyplesin I (Tac), is tagged with the polyhydroxyalkanoate-granule-associated protein (PhaP) and immobilized on haloarchaea-produced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) via hydrophobic interaction...
May 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/29776921/determining-the-pneumococcal-conjugate-vaccine-coverage-required-for-indirect-protection-against-vaccine-type-pneumococcal-carriage-in-low-and-middle-income-countries-a-protocol-for-a-prospective-observational-study
#5
Jocelyn Chan, Cattram D Nguyen, Jana Y R Lai, Eileen M Dunne, Ross Andrews, Christopher C Blyth, Siddhartha Datta, Kim Fox, Rebecca Ford, Jason Hinds, Sophie La Vincente, Deborah Lehmann, Ruth Lim, Tuya Mungun, Paul N Newton, Rattanaphone Phetsouvanh, Willam S Pomat, Anonh Xeuatvongsa, Claire von Mollendorf, David A B Dance, Catherine Satzke, Kim Muholland, Fiona M Russell
INTRODUCTION: Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children using hospital-based NP pneumococcal carriage surveillance at three sites in Asia and the Pacific...
May 18, 2018: BMJ Open
https://www.readbyqxmd.com/read/29774289/high-prevalence-of-intestinal-worms-in-children-up-to-5-years-of-age-in-huaphan-province-lao-people-s-democratic-republic-pdr
#6
Naphavanh Nanthavong, Antony P Black, Phonepadith Khattignavong, Lavy Lorphachan, Keooudomphone Vilivong, Sylvie Goossens, Yves Buisson, Fabrice Quet, Claude P Muller, Satoshi Nakamura
Background: The prevalence of soil-transmitted helminth infection is high in Lao People's Democratic Republic (PDR), reaching 62% among school-children. However, this prevalence presents wide regional variations, due to differences in healthcare access and environmental factors. Curiously, there are few studies on helminth infections in pre-school children - an age group targeted by the national de-worming campaign. Therefore, a preliminary study was conducted in a remote region of Huaphan Province, North Laos, to determine the prevalence of helminth infections in pre-school children...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29771902/the-impact-of-different-tumour-subtypes-on-management-and-survival-of-new-zealand-women-with-stage-i-iii-breast-cancer
#7
Ross Lawrenson, Chunhuan Lao, Ian Campbell, Vernon Harvey, Sanjeewa Seneviratne, Mark Elwood, Diana Sarfati, Marion Kuper-Hommel
AIMS: This study aims to describe the prevalence and characteristics of the different ER/PR/HER2 subtypes in New Zealand women with breast cancer, and to explore their treatment and outcomes. METHODS: This study included women diagnosed with Stage I-III breast cancer between January 2006 and May 2013, recorded in the combined Waikato and Auckland Breast Cancer Registers, and with complete data on their ER, PR and HER2 status. Five ER/PR/HER2 phenotypes were classified...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29770818/luminescence-and-thermal-behaviors-of-free-and-trapped-excitons-in-cesium-lead-halide-perovskite-nanosheets
#8
Xiangzhou Lao, Zhi Yang, Zhicheng Su, Zilan Wang, Honggang Ye, Minqiang Wang, Xi Yao, Shijie Xu
Very recently, all-inorganic perovskite CsPbX3 (X = Cl, Br, I) nanostructures such as nanoparticles, nanoplates, and nanorods have been extensively explored. These CsPbX3 nanostructures exhibit excellent optical properties; however, the photophysics involved is not yet clear. Herein, the emission properties and luminescence mechanism of CsPbBr3 nanosheets (NSs) were investigated using steady-state and time-resolved photoluminescence (PL) spectroscopic techniques. Moreover, two kinds of excitonic emissions (Peak 1 and Peak 2) are observed at low temperatures (<80 K) under the conditions of low excitation level...
May 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29769346/porcine-deltacoronavirus-accessory-protein-ns6-antagonizes-ifn-%C3%AE-production-by-interfering-with-the-binding-of-rig-i-mda5-to-double-stranded-rna
#9
Puxian Fang, Liurong Fang, Jie Ren, Yingying Hong, Xiaorong Liu, Yunyang Zhao, Dang Wang, Guiqing Peng, Shaobo Xiao
Porcine deltacoronavirus (PDCoV) has recently emerged as an enteric pathogen that can cause serious vomiting and diarrhea in suckling piglets. The first outbreak of PDCoV occurred in the United States in 2014 and was followed by reports of PDCoV in South Korea, China, Thailand, Lao people's Democratic Republic, and Vietnam, leading to economic losses for pig farms and posing considerable threat to the swine industry worldwide. Our previous studies have shown that PDCoV encodes three accessory proteins, NS6, NS7, and NS7a, but the functions of these proteins in viral replication, pathogenesis, and immune regulation remain unclear...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29767527/tuning-solvated-electrons-by-polar-nonpolar-oxide-heterostructure
#10
Yanan Wang, Hongli Guo, Qijing Zheng, Wissam A Saidi, Jin Zhao
Solvated electron states at oxide/aqueous interface represent the lowest energy charge transfer pathways, thereby playing an important role in photocatalysis and electronic device applications. However, their energies are usually higher than the conduction band minimum (CBM), which makes the solvated electrons difficult to utilize in charge transfer processes. Thus, it is essential to stabilize the energy of the solvated electron states. In this report, taking LaAlO3/SrTiO3 (LAO/STO) oxide heterostructure with H2O adsorbed monolayer as a prototypical system, we show using DFT and ab initio time dependent nonadiabatic molecular dynamics simulation that the energy and dynamics of solvated electrons can be tuned by the electric field in the polar-nonpolar oxide heterostructure...
May 16, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29764965/effect-of-treat-to-target-strategies-aiming-at-remission-of-arterial-stiffness-in-early-rheumatoid-arthritis-a-randomized-controlled-study
#11
Lydia Ho-Pui Tam, Qing Shang, Edmund Kwok-Ming Li, Priscilla Ching-Han Wong, Kitty Yan Kwok, Emily Wai-Lin Kun, Isaac Cheuk-Wan Yim, Violet Ka-Lai Lee, Ronald Man-Lung Yip, Steve Hin-Ting Pang, Virginia Weng-Nga Lao, Queenie Wah-Yan Mak, Isaac Tsz-Ho Cheng, Xerox Sze-Lok Lau, Tena Ka-Yan Li, Tracy Yaner Zhu, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVE: To determine the efficacy of 2 tight control treatment strategies aiming at Simplified Disease Activity Score (SDAI) remission (SDAI ≤ 3.3) compared to 28-joint count Disease Activity Score (DAS28) remission (DAS28 < 2.6) in the prevention of arterial stiffness in patients with early rheumatoid arthritis (RA). METHODS: This was an open-label study in which 120 patients with early RA were randomized to receive 1 year of tight control treatment. Group 1 (n = 60) aimed to achieve SDAI ≤ 3...
May 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29763458/immunity-levels-to-poliovirus-in-lao-children-and-adults-before-the-vaccine-derived-poliovirus-outbreak-a-retrospective-study
#12
Maude Pauly, Antony P Black, Phonepaseuth Khampanisong, Phonethipsavanh Nouanthong, Judith M Hübschen, Naphavanh Nanthavong, Kong Sayasinh, Prapan Jutavijittum, Bounthome Samountry, Anonh Xeuatvongsa, Sabine Diedrich, Claude P Muller
In 2015, several provinces in Lao People's Democratic Republic (Lao PDR) experienced a vaccine-derived poliovirus outbreak. This survey was conducted (i) to evaluate the vaccination coverage in different settings and cohorts using the seroprevalence of anti-poliovirus (PV) antibodies as a surrogate measure, and (ii) to explore the usefulness of an ELISA in a country with limited resources and a specific epidemiological setting. IgG antibodies were assessed by ELISA in Lao children (n = 1216) and adults (n = 1228), including blood donors and health care workers...
2018: PloS One
https://www.readbyqxmd.com/read/29763452/factors-affecting-forest-area-change-in-southeast-asia-during-1980-2010
#13
Nobuo Imai, Takuya Furukawa, Riyou Tsujino, Shumpei Kitamura, Takakazu Yumoto
While many tropical countries are experiencing rapid deforestation, some have experienced forest transition (FT) from net deforestation to net reforestation. Numerous studies have identified causative factors of FT, among which forest scarcity has been considered as a prerequisite for FT. In fact, in SE Asia, the Philippines, Thailand and Viet Nam, which experienced FT since 1990, exhibited a lower remaining forest area (30±8%) than the other five countries (68±6%, Cambodia, Indonesia, Laos, Malaysia, and Myanmar) where forest loss continues...
2018: PloS One
https://www.readbyqxmd.com/read/29761761/leptospirosis-among-returned-travelers-a-geosentinel-site-survey-and-multicenter-analysis-1997-2016
#14
Sophia G de Vries, Benjamin J Visser, Rhett J Stoney, Jiri F P Wagenaar, Emmanuel Bottieau, Lin H Chen, Annelies Wilder-Smith, Mary Wilson, Christophe Rapp, Karin Leder, Eric Caumes, Eli Schwartz, Noreen A Hynes, Abraham Goorhuis, Douglas H Esposito, Davidson H Hamer, Martin P Grobusch, For The GeoSentinel Surveillance Network
Leptospirosis is a potentially fatal emerging zoonosis with worldwide distribution and a broad range of clinical presentations and exposure risks. It typically affects vulnerable populations in (sub)tropical countries but is increasingly reported in travelers as well. Diagnostic methods are cumbersome and require further improvement. Here, we describe leptospirosis among travelers presenting to the GeoSentinel Global Surveillance Network. We performed a descriptive analysis of leptospirosis cases reported in GeoSentinel from January 1997 through December 2016...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29761219/intracranial-rescue-stent-angioplasty-after-stent-retriever-thrombectomy-multicenter-experience
#15
Robert Forbrig, Hannah Lockau, Fabian Flottmann, Tobias Boeckh-Behrens, Christoph Kabbasch, Maximilian Patzig, Anastasios Mpotsaris, Jens Fiehler, Thomas Liebig, Goetz Thomalla, Oezguer A Onur, Silke Wunderlich, Kornelia Kreiser, Moriz Herzberg, Frank A Wollenweber, Sascha Prothmann, Franziska Dorn
PURPOSE: Stent-retriever thrombectomy (SRT) for acute intracranial large artery occlusion (LAO) may not result in permanent recanalization in rare cases, e.g. due to an underlying stenosis or dissection. In this specific patient group, rescue stent angioplasty (RSA) may be the only treatment option to achieve permanent vessel patency and potentially a good clinical outcome. To date, the experience with RSA is limited. METHODS: In this retrospective analysis, interventional and clinical data of patients with acute intracranial LAO of the anterior and posterior circulation who underwent RSA after SRT due to an underlying lesion between 2012-2017 in four neurovascular centers were studied...
May 14, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29756338/marsupialization-of-mandibular-cystic-ameloblastoma-retrospective-study-of-7-years
#16
Zinan Yang, Qian Liang, Le Yang, Guang-Sen Zheng, Si-En Zhang, Xiao-Mei Lao, Yu-Jie Liang, Gui-Qing Liao
BACKGROUND: This retrospective study investigated the reduction rate and speed of shrinkage after marsupialization in mandibular cystic ameloblastoma and clarified whether marsupialization is appropriate for unicystic ameloblastoma and multicystic ameloblastoma. METHODS: Sixty-three patients with mandibular cystic ameloblastoma were initially treated with marsupialization. Premarsupialization and postmarsupialization panoramic radiographs were reviewed for reduction rate and speed of shrinkage, and then were evaluated with age, sex, tumor location, and tumor type...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29753251/long-term-exposure-to-ambient-particulate-matter-pm-2-5-is-associated-with-platelet-counts-in-adults
#17
Zilong Zhang, Ta-Chien Chan, Cui Guo, Ly-Yun Chang, Changqing Lin, Yuan Chieh Chuang, Wun Kai Jiang, Kin Fai Ho, Tony Tam, Kam S Woo, Alexis K H Lau, Xiang Qian Lao
BACKGROUND: The prothrombotic effects of particulate matter (PM) may underlie the association of air pollution with increased risks of cardiovascular disease. This study aimed to investigate the association between long-term exposure to PM with an aerodynamic diameter ≤2.5 μm (PM2.5 ) and platelet counts, a marker of coagulation profiles. METHODS: The study participants were from a cohort consisting of 362,396 Taiwanese adults who participated in a standard medical examination program between 2001 and 2014...
May 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29752653/imaging-neurodegeneration-in-down-syndrome-brain-templates-for-amyloid-burden-and-tissue-segmentation
#18
Patrick J Lao, Ben L Handen, Tobey J Betthauser, Karly A Cody, Annie D Cohen, Dana L Tudorascu, Charles K Stone, Julie C Price, Sterling C Johnson, William E Klunk, Bradley T Christian
The focus of Alzheimer's disease (AD) neuroimaging research has shifted towards an investigation of the earliest stages of AD pathogenesis, which manifests in every young adult with Down syndrome (DS; trisomy 21) resulting from a deterministic genetic predisposition to amyloid precursor protein overproduction. Due to morphological differences in brain structure in the DS population, special consideration must be given to processing pipelines and the use of normative atlases developed for the non-DS population...
May 11, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29751735/identification-of-compounds-that-prolong-type-i-interferon-signaling-as-potential-vaccine-adjuvants
#19
Nikunj M Shukla, Kei-Ichiro Arimoto, Shiyin Yao, Jun-Bao Fan, Yue Zhang, Fumi Sato-Kaneko, Fitzgerald S Lao, Tadashi Hosoya, Karen Messer, Minya Pu, Howard B Cottam, Dennis A Carson, Tomoko Hayashi, Dong-Er Zhang, Maripat Corr
Vaccines are reliant on adjuvants to enhance the immune stimulus, and type I interferons (IFNs) have been shown to be beneficial in augmenting this response. We were interested in identifying compounds that would sustain activation of an endogenous type I IFN response as a co-adjuvant. We began with generation of a human monocytic THP-1 cell line with an IFN-stimulated response element (ISRE)-β-lactamase reporter construct for high-throughput screening. Pilot studies were performed to optimize the parameters and conditions for this cell-based Förster resonance energy transfer (FRET) reporter assay for sustaining an IFN-α-induced ISRE activation signal...
May 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29749405/natural-compound-oblongifolin-c-confers-gemcitabine-resistance-in-pancreatic-cancer-by-downregulating-src-mapk-erk-pathways
#20
Yang Li, Zhichao Xi, Xiaoqiong Chen, Shuangfan Cai, Chen Liang, Zhen Wang, Yingyi Li, Hongsheng Tan, Yuanzhi Lao, Hongxi Xu
Gemcitabine (GEM)-induced drug resistance is the major reason for the failure of chemotherapy in pancreatic cancer (PC). In this study, we found that Oblongifolin C (OC) efficiently inhibited PC cell proliferation by inducing G0/G1 arrest and apoptosis. Also, our mechanism study demonstrated that OC re-sensitized the GEM-resistant PC cells through the ubiquitin-proteasome-dependent degradation of Src, and then downregulating the MAPK pathway. Knockdown of Src plus OC resulted in a greater inhibitory effect in GEM-resistant PC cells...
May 10, 2018: Cell Death & Disease
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