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https://www.readbyqxmd.com/read/29475207/the-impact-of-soccer-match-play-on-the-muscle-damage-response-in-youth-female-athletes
#1
Jonathan D Hughes, Katrina Denton, Rhodri S Lloyd, Jon L Oliver, Mark De Ste Croix
Post-match assessment of creatine kinase (CK) activity and delayed-onset muscle soreness (DOMS) are common markers of exercise-induced muscle damage and recovery status in soccer players. These responses have not been examined in youth female players. This study examined the effect of competitive match play on CK activity and DOMS in elite youth players. Thirty-four elite female players, divided into three chronological age groups (U13, n=11; U15, n=10; U17 n=12). Players completed baseline testing for CK and DOMS that was repeated immediately (for DOMS), 80, 128 and 168 h post-competitive match play for CK...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475191/factor-structure-and-psychometric-properties-of-a-romanian-translation-of-the-drive-for-muscularity-scale-dms-in-university-men
#2
Viren Swami, Mona Vintila, Otilia Tudorel, Cosmin Goian, David Barron
We examined the psychometric properties of a Romanian translation of the 15-item Drive for Muscularity Scale (DMS). Male university students from Romania (N = 343) completed the DMS, as well as measures of self-esteem, body appreciation, and muscle discrepancy. Exploratory factor analysis indicated that DMS scores reduced to two factors that related to muscularity-oriented attitudes and behaviours, with both first-order factors loading onto a higher-order factor. However, confirmatory factor analysis indicated that a model with two first-order factors and a higher-order factor had poor fit...
February 20, 2018: Body Image
https://www.readbyqxmd.com/read/29475131/factors-affecting-premature-plantarflexor-muscle-activity-during-hemiparetic-gait
#3
Kazuki Fujita, Hiroichi Miaki, Akira Fujimoto, Hideaki Hori, Hitomi Fujimoto, Yasutaka Kobayashi
In hemiparetic stroke survivors, premature plantarflexor muscle activity (PPF) often appears as a gait abnormality from terminal swing to the loading response on the paretic side. This study aimed to discern factors giving rise to PPF. Lower extremity function, spasticity magnitude, and gait electromyograms were assessed in 31 hemiparetic stroke survivors. Mean amplitudes during gait phases were determined for the paretic soleus, tibialis anterior, rectus femoris, and biceps femoris. The subjects were classified into PPF and non-PPF groups based on their relative soleus amplitude at different phases of gait, and group differences in each measurement were calculated and subjected to logistic regression...
February 14, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29475130/the-influence-of-winter-and-summer-seasons-on-physical-fitness-in-aged-population
#4
P Bezerra, Luis P Rodrigues, C Ayan, J M Cancela
Epidemiological studies have described the association between physical fitness and health. Few have reported the impact of seasonal variation on fitness determinants, in elderly. We investigated the effects of summer and winter environmental conditions on physical fitness, in both exercise and non-exercise elders. 371 non-institutionalized older adults (74.1% female; 78.4 ± 5.3 years) randomly recruited from a total sample of 1338 subjects from north of Portugal, were prospectively followed during 1 year and 3 assessments were performed - April (baseline), October (summer season) and April (winter season)...
February 15, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29475111/pth-1-34-and-growth-hormone-in-prevention-of-disuse-osteopenia-and-sarcopenia-in-rats
#5
Mikkel Bo Brent, Annemarie Brüel, Jesper Skovhus Thomsen
Osteopenia and sarcopenia develops rapidly during disuse. The study investigated whether intermittent parathyroid hormone (1-34) (PTH) and growth hormone (GH) administered alone or in combination could prevent or mitigate disuse osteopenia and sarcopenia in rats. Disuse was achieved by injecting 4 IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats. Seventy-two rats were divided into six groups: 1. Baseline; 2. Ctrl; 3. BTX; 4. BTX + GH; 5. BTX + PTH; 6...
February 20, 2018: Bone
https://www.readbyqxmd.com/read/29475048/the-function-of-serpin-2-from-eriocheir-sinensis-in-spiroplasma-eriocheiris-infection
#6
Meijun Yuan, Mingxiao Ning, Panpan Wei, Wenjing Hao, Yunting Jing, Wei Gu, Wen Wang, Qingguo Meng
Serpin families classified serine protease inhibitors regulate various physiological processes. However, there is not study on the role of serpin in immune responses against Spiroplasma eriocheiris as a novel causative pathogen in the Chinese mitten crab, Eriocheir sinensis. In our study, quantitative real-time PCR (qRT-PCR) revealed that the mRNA transcripts of Esserpin-2 were ubiquitous in every tissue, relative higher expression in hepatopancreas, gill and hemocytes, while the intestine, muscle, heart and nerve showed relative lower expression...
February 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29475025/protein-anchoring-therapy-to-target-extracellular-matrix-proteins-to-their-physiological-destinations
#7
REVIEW
Mikako Ito, Kinji Ohno
Endplate acetylcholinesterase (AChE) deficiency is a form of congenital myasthenic syndrome (CMS) caused by mutations in COLQ, which encodes collagen Q (ColQ). ColQ is an extracellular matrix (ECM) protein that anchors AChE to the synaptic basal lamina. Biglycan, encoded by BGN, is another ECM protein that binds to the dystrophin-associated protein complex (DAPC) on skeletal muscle, which links the actin cytoskeleton and ECM proteins to stabilize the sarcolemma during repeated muscle contractions. Upregulation of biglycan stabilizes the DPAC...
February 20, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29474996/considerations-for-exercise-prescription-in-patients-with-bone-metastases-a-comprehensive-narrative-review
#8
REVIEW
Gráinne Sheill, Emer M Guinan, Nicola Peat, Juliette Hussey
Metastatic disease is a frequent complication of advanced cancer, with bone representing one of the most common sites of metastatic occurrence. Patients with bone metastases receive long-term systemic treatments which have a significant attritional impact on muscle strength, fatigue and physical functioning. Physical rehabilitation involving exercise and physical activity prescription has a considerable role in counteracting these changes however exercise is often perceived as a contraindication in the presence of bone metastases due to concerns about aggravating skeletal related events...
February 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29474953/gaba-ergic-neurotransmission-in-the-nucleus-of-the-solitary-tract-modulates-cough-in-the-cat
#9
Z Kotmanova, M Simera, M Veternik, L Martvon, J Misek, J Jakus, T Y Shen, M N Musselwhite, T Pitts, D C Bolser, I Poliacek
GABA, muscimol, and baclofen were microinjected into the rostral (rNTS) and caudal solitary tract nucleus (cNTS) in 24 anesthetized cats. Electromyograms (EMGs) of diaphragm (DIA) and abdominal muscles (ABD), blood pressure and esophageal pressure (EP) were recorded and analysed. Bilateral microinjections of 1 mM GABA (total 66 ± 4 nl), 1 mM baclofen (64 ± 4 nl) and unilateral microinjections of 0.5 mM muscimol (33 ± 1 nl) in the rNTS significantly reduced cough number (CN), amplitudes of ABD EMGs, expiratory EP, and prolonged the duration of the cough inspiratory phase...
February 20, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29474900/hepatoprotective-effect-of-forsythiae-fructuse-water-extract-against-carbon-tetrachloride-induced-liver-fibrosis-in-mice
#10
Yi Zhang, Hui Miao, Hongyu Yan, Yuchen Sheng, Lili Ji
ETHNOPHARMACOLOGICAL RELEVANCE: The fruit of Forsythia suspensa (Thunb.) Vahl, named Forsythiae Fructus (Lian-Qiao), is a well-known traditional Chinese medicine (TCM) used for clearing away heat and toxic material, eliminating the mass and relieving swelling. AIM OF THE STUDY: This study aims to observe the attenuation of the water extract of Forsythiae Fructus (FSE) on carbon tetrachloride (CCl4 )-induced hepatic fibrosis in male C57BL/6 mice. MATERIALS AND METHODS: Hepatic fibrosis was induced in male C57BL/6 mice by intraperitoneal injection with 2ml/kg CCl4 (mixed 1: 3 in olive oil) twice a week for 4 weeks...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29474863/attenuated-strength-gains-during-prolonged-resistance-exercise-training-in-older-adults-with-high-inflammatory-status
#11
Roland W J Hangelbroek, Pim Knuiman, Michael Tieland, Lisette C P G M de Groot
OBJECTIVES: Chronic systemic low grade inflammation is associated with the age-related loss of muscle mass. Resistance exercise has been suggested to reduce or lower chronic systemic low grade inflammation. However, systemic chronic low-grade inflammation may adversely affect the adaptive response to exercise training. We investigated the effect of resistance exercise training on systemic chronic low-grade inflammation in older adults. In addition, we studied the association between systemic chronic low-grade inflammation and the adaptive response to exercise training...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29474837/mitochondrial-accumulation-of-doxorubicin-in-cardiac-and-diaphragm-muscle-following-exercise-preconditioning
#12
Aaron B Morton, Andres Mor, J Matthew Hinkley, Noriko Ichinoseki-Sekine, Demetra D Christou, Ashley J Smuder
Doxorubicin (DOX) is a highly effective anthracycline antibiotic. Unfortunately, the clinical use of DOX is limited by the risk of deleterious effects to cardiac and respiratory (i.e. diaphragm) muscle, resulting from mitochondrial reactive oxygen species (ROS) production. In this regard, exercise is demonstrated to protect against DOX-induced myotoxicity and prevent mitochondrial dysfunction. However, the protective mechanisms are currently unclear. We hypothesized that exercise may induce protection by increasing the expression of mitochondria-specific ATP-binding cassette (ABC) transporters and reducing mitochondrial DOX accumulation...
February 20, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29474819/direct-evidence-for-high-affinity-blockade-of-na-v-1-6-channel-subtype-by-huwentoxin-iv-spider-peptide-using-multiscale-functional-approaches
#13
Tânia C Gonçalves, Rachid Boukaiba, Jordi Molgó, Muriel Amar, Michel Partiseti, Denis Servent, Evelyne Benoit
The Chinese bird spider huwentoxin-IV (HwTx-IV) is well-known to be a highly potent blocker of NaV 1.7 subtype of voltage-gated sodium (NaV ) channels, a genetically validated analgesic target, and thus promising as a potential lead molecule for the development of novel pain therapeutics. In the present study, the interaction between HwTx-IV and NaV 1.6 channel subtype was investigated using multiscale (from in vivo to individual cell) functional approaches. HwTx-IV was approximatively 2 times more efficient than tetrodotoxin (TTX) to inhibit the compound muscle action potential recorded from the mouse skeletal neuromuscular system in vivo, and 30 times more effective to inhibit nerve-evoked than directly-elicited muscle contractile force of isolated mouse hemidiaphragms...
February 20, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29474663/muscle-ischaemia-associated-with-nxp2-autoantibodies-a-severe-subtype-of-juvenile-dermatomyositis
#14
Jessie Aouizerate, Marie De Antonio, Brigitte Bader-Meunier, Christine Barnerias, Christine Bodemer, Arnaud Isapof, Pierre Quartier, Isabelle Melki, Jean-Luc Charuel, Guillaume Bassez, Isabelle Desguerre, Romain K Gherardi, François-Jérôme Authier, Cyril Gitiaux
Objectives: Myositis-specific autoantibodies (MSAs) are increasingly used to delineate distinct subgroups of JDM. The aim of our study was to explore without a priori hypotheses whether MSAs are associated with distinct clinical-pathological changes and severity in a monocentric JDM cohort. Methods: Clinical, biological and histological findings from 23 JDM patients were assessed. Twenty-six histopathological parameters were subjected to multivariate analysis. Results: Autoantibodies included anti-NXP2 (9/23), anti-TIF1γ (4/23), anti-MDA5 (2/23), no MSAs (8/23)...
February 20, 2018: Rheumatology
https://www.readbyqxmd.com/read/29474563/effects-of-heat-stress-during-porcine-reproductive-and-respiratory-syndrome-virus-infection-on-metabolic-responses-in-growing-pigs
#15
K M Seelenbinder, L D Zhao, M D Hanigan, M W Hulver, R P McMillan, L H Baumgard, J T Selsby, J W Ross, N K Gabler, R P Rhoads
Heat stress and immune challenges negatively impact nutrient allocation and metabolism in swine, especially due to elevated heat load. In order to assess the effects of heat stress during porcine reproductive and respiratory syndrome virus (PRRSV) infection on metabolism, 9-week old crossbred barrows were individually housed, fed ad libitum, divided into four treatments: thermo-neutral (TN), thermo-neutral PRRSV infected (TP), heat stress (HS), and heat stress PRRSV infected (HP), and subjected to two experimental phases...
February 21, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29474540/speg-deficient-skeletal-muscles-exhibit-abnormal-triad-and-defective-calcium-handling
#16
Virginia Huntoon, Jeffrey J Widrick, Colline Sanchez, Samantha M Rosen, Candice Kutchukian, Siqi Cao, Christopher R Pierson, Xiaoli Liu, Mark A Perrella, Alan H Beggs, Vincent Jacquemond, Pankaj B Agrawal
Centronuclear myopathies (CNM) are a subtype of congenital myopathies (CM) characterized by skeletal muscle weakness and an increase in the number of central myonuclei. We have previously identified three CNM probands, two with associated dilated cardiomyopathy, carrying striated preferentially expressed gene (SPEG) mutations. Currently, the role of SPEG in skeletal muscle function is unclear as constitutive SPEG-deficient mice developed severe dilated cardiomyopathy and died in-utero. We have generated a conditional Speg-KO mouse model and excised Speg by crosses with striated muscle-specific cre-expressing mice (MCK-Cre)...
February 20, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29474538/how-the-most-common-mitochondrial-dna-mutation-m-3243a-g-vanishes-from-leukocytes-a-mathematical-model
#17
Reiner A Veitia
Mitochondrial diseases may be caused by alterations of the mitochondrial genome. The pathogenic variant m.3243A>G is one of the most frequent causes of mitochondrial disease and the most common mitochondrial DNA mutation. Patients with a variant in mitochondrial DNA can have a mixture of mutated and wild-type genomes (heteroplasmy). In the case of the pathogenic variant m.3243A>G, the degree of heteroplasmy (H) correlates to some extent with the severity of the disease. Several longitudinal studies, where H is measured at two different time-points, have shown an annual decline in leukocyte H values...
February 20, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29474527/aesthetic-improvement-of-undeveloped-calves-after-treatment-of-congenital-clubfoot-deformity
#18
Katarina Andjelkov, Ramon Llull, Milan Colic, Tatjana C Atanasijevic, Vesna M Popovic, Miodrag Colic
Background: Even when clubfoot deformity is treated in a timely manner, the consequences observed in adulthood include hypoplasia of the calf muscles, gait impairment, decreases in foot size and can also affect the tibial length. These consequences may have negative impacts on the patient's subjective appraisal of long-term outcomes, and can influence the patient's self-esteem in both male and female patients. Objectives: We present our experience in the treatment of undeveloped calves after surgical treatment of congenital clubfoot...
February 21, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29474484/transgenerational-effects-of-prenatal-restricted-diet-on-gene-expression-and-histone-modifications-in-the-rat
#19
Joanna Nowacka-Woszuk, Izabela Szczerbal, Anna M Malinowska, Agata Chmurzynska
Dietary triggers acting on a developing fetus can affect the functioning of the body in later life; this can be observed on various levels, including epigenetic modifications and gene expression. Early-life programmed changes may be transmitted to successive generations. In this study, the impact of prenatal restricted diet was studied in four generations of rats. We hypothesized that this diet can induce changes in the expression of major genes involved in two epigenetic mechanisms: DNA methylation and histone modifications...
2018: PloS One
https://www.readbyqxmd.com/read/29474465/strength-improvements-through-occlusal-splints-the-effects-of-different-lower-jaw-positions-on-maximal-isometric-force-production-and-performance-in-different-jumping-types
#20
Christian Maurer, Sebastian Heller, Jil-Julia Sure, Daniel Fuchs, Christoph Mickel, Eileen M Wanke, David A Groneberg, Daniela Ohlendorf
OBJECTIVE: The influence of the jaw position on postural control, body posture, walking and running pattern has been reported in the literature. All these movements have in common that a relatively small, but well controlled muscle activation is required. The induced effects on motor output through changed jaw positions have been small. Therefore, it has been questioned if it could still be observed in maximal muscle activation. METHOD: Twenty-three healthy, mid age recreational runners (mean age = 34...
2018: PloS One
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