keyword
https://read.qxmd.com/read/38519767/co-processed-crystalline-solids-of-ivermectin-with-span-%C3%A2-60-as-solubility-enhancers-of-ivermectin-in-natural-oils
#21
JOURNAL ARTICLE
Luandri de Vos, Minja Gerber, Wilna Liebenberg, Johanna C Wessels, Hendrik J R Lemmer
Despite being discovered over five decades ago, little is still known about ivermectin. Ivermectin has several physico-chemical properties that can result in it having poor bioavailability. In this study, polymorphic and co-crystal screening was used to see if such solid-state modifications can improve the oil solubility of ivermectin. Span® 60, a lipophilic non-ionic surfactant, was chosen as co-former. The rationale behind attempting to improve oil solubility was to use ivermectin in future topical and transdermal preparations to treat a range of skin conditions like scabies and head lice...
March 22, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38519629/correction-separable-and-inseparable-silk-fibroin-microneedles-for-the-transdermal-delivery-of-colchicine-development-characterization-and-comparisons
#22
Shiji Liao, Guirong Qiu, Yanping Hu, Bohong Guo, Yuqin Qiu
No abstract text is available yet for this article.
March 22, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38514495/a-comprehensive-review-of-hydrogel-based-drug-delivery-systems-classification-properties-recent-trends-and-applications
#23
REVIEW
Huma Hameed, Saleha Faheem, Ana Cláudia Paiva-Santos, Hafiz Shoaib Sarwar, Muhammad Jamshaid
As adaptable biomaterials, hydrogels have shown great promise in several industries, which include the delivery of drugs, engineering of tissues, biosensing, and regenerative medicine. These hydrophilic polymer three-dimensional networks have special qualities like increased content of water, soft, flexible nature, as well as biocompatibility, which makes it excellent candidates for simulating the extracellular matrix and promoting cell development and tissue regeneration. With an emphasis on their design concepts, synthesis processes, and characterization procedures, this review paper offers a thorough overview of hydrogels...
March 21, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38514482/state-of-the-art-of-silica-nanoparticles-an-overview-on-biodistribution-and-preclinical-toxicity-studies
#24
REVIEW
Joshua Yu, Nirnoy Dan, Seyyed Majid Eslami, Xiuling Lu
Over the past few years, nanoparticles have drawn particular attention in designing and developing drug delivery systems due to their distinctive advantages like improved pharmacokinetics, reduced toxicity, and specificity. Along with other successful nanosystems, silica nanoparticles (SNPs) have shown promising effects for therapeutic and diagnostic purposes. These nanoparticles are of great significance owing to their modifiable surface with various ligands, tunable particle size, and large surface area. The rate and extent of degradation and clearance of SNPs depend on factors such as size, shape, porosity, and surface modification, which directly lead to varying toxic mechanisms...
March 21, 2024: AAPS Journal
https://read.qxmd.com/read/38514405/the-association-of-maternal-periodontal-diseases-in-the-postpartum-period-with-preterm-low-birth-weight
#25
JOURNAL ARTICLE
Sutitorn Yanaranci, Narongsak Laosrisin, Awipha Sriprasertsuk, Patchawan Panrin, Teerachate Nantakeeratipat
AIM: Preterm birth is the most adverse effect of pregnancy, commonly leading to low birth weight. Our study aimed to assess the relationship between maternal periodontal status and adverse pregnancy outcomes by immediate postpartum periodontal examination and diagnosis. MATERIALS AND METHODS: 125 mothers were divided into four groups based on gestational day (GD) and newborns' birth weight (BW); the mothers with GD ≥ 259 days and BW ≥ 2500 gm (Control), the mothers with GD <259 days and BW ≥ 2500 gm (PT group), the mothers with GD ≥ 259 days and BW <2500 gm (LBW group), and the mothers with GD <259 days and BW <2500 gm (PT-LBW group)...
February 1, 2024: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/38510205/omics-data-analysis-reveals-the-system-level-constraint-on-cellular-amino-acid-composition
#26
JOURNAL ARTICLE
Yuanyuan Huang, Zhitao Mao, Yue Zhang, Jianxiao Zhao, Xiaodi Luan, Ke Wu, Lili Yun, Jing Yu, Zhenkun Shi, Xiaoping Liao, Hongwu Ma
Proteins play a pivotal role in coordinating the functions of organisms, essentially governing their traits, as the dynamic arrangement of diverse amino acids leads to a multitude of folded configurations within peptide chains. Despite dynamic changes in amino acid composition of an individual protein (referred to as AAP) and great variance in protein expression levels under different conditions, our study, utilizing transcriptomics data from four model organisms uncovers surprising stability in the overall amino acid composition of the total cellular proteins (referred to as AACell)...
June 2024: Synthetic and Systems Biotechnology
https://read.qxmd.com/read/38509153/air-pollution-exposure-may-impact-the-composition-of-human-milk-oligosaccharides
#27
JOURNAL ARTICLE
Noopur C Naik, Elizabeth A Holzhausen, Bridget N Chalifour, Maria M Coffman, Fredrick Lurmann, Michael I Goran, Lars Bode, Tanya L Alderete
Human milk oligosaccharides (HMOs) impact neonate immunity and health outcomes. However, the environmental factors influencing HMO composition remain understudied. This study examined the associations between ambient air pollutant (AAP) exposure and HMOs at 1-month postpartum. Human milk samples were collected at 1-month postpartum (n = 185). AAP (PM2.5 , PM10 , NO2 ) exposure included the 9-month pregnancy period through 1-month postpartum. Associations between AAP with (1) HMO diversity, (2) the sum of sialylated and fucosylated HMOs, (3) 6 a priori HMOs linked with infant health, and (4) all HMOs were examined using multivariable linear regression and principal component analysis (PCA)...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508078/an-overlooked-compound-contributing-to-boar-taint-and-consumer-rejection-of-meat-products-2-aminoacetophenone
#28
JOURNAL ARTICLE
Daniel Mörlein, Johanna Mörlein, Christoph Gerlach, Micha Strack, Bertolt Kranz, Dagmar A Brüggemann
Mainly skatole and androstenone have so far been considered causative for boar taint. Using a mixed methods approach it is shown herein that 2-aminoacetophenone (AAP) affects human perception of pork, too. We explored the importance of AAP in four trials: (1) chemical analyses of 221 fat samples from boar carcasses revealed that AAP occurs, on average, in similar quantities as skatole while the levels of androstenone being four-fold. (2) ranking tests with mixtures of androstenone and/or skatole with AAP presented on smell strips to trained sensory assessors showed that AAP amplifies boar odour...
March 15, 2024: Meat Science
https://read.qxmd.com/read/38507928/a-generalizable-sensing-platform-based-on-molecularly-imprinted-polymer-aptamer-double-recognition-and-nanoenzyme-assisted-photoelectrochemical-colorimetric-dual-mode-detection
#29
JOURNAL ARTICLE
Ying-Zhuo Shen, Wen Zheng Xie, Zheng Wang, Kang Ping Ning, Zheng Ping Ji, Hong Bo Li, Xiao-Ya Hu, Cheng Ma, Xu Qin
Developing highly sensitive and selective methods that incorporate specific recognition elements is crucial for detecting small molecules because of the limited availability of small molecule antibodies and the challenges in obtaining sensitive signals. In this study, a generalizable photoelectrochemical-colorimetric dual-mode sensing platform was constructed based on the synergistic effects of a molecularly imprinted polymer (MIP)-aptamer sandwich structure and nanoenzymes. The MIP functionalized peroxidase-like Fe3 O4 (Fe3 O4 @MIPs) and alkaline phosphatase mimic Zr-MOF labeled aptamer (Zr-mof@Apt) were used as the recognition elements...
March 11, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38507230/brief-resolved-unexplained-events-practical-evaluation-and-management-in-the-emergency-department
#30
JOURNAL ARTICLE
Lukas R Austin-Page, Christine S Cho
In a 2016 clinical practice guideline, the American Academy of Pediatrics (AAP) created and introduced the term brief resolved unexplained event (BRUE). This guideline defined specific criteria for diagnosis of BRUE and provided a set of guidelines for evaluation of these infants as well as characteristics that indicate a BRUE will have a low risk for a repeat event or a serious underlying disorder. This issue reviews the definition and broad differential diagnosis of a BRUE, highlights the criteria for risk stratification of infants who experience a BRUE, summarizes the management recommendations for patients with a lower-risk BRUE, and examines the available literature that evaluates the impact of the AAP guidelines in the years since its publication...
April 2024: Pediatric Emergency Medicine Practice
https://read.qxmd.com/read/38503171/exploring-the-associations-of-demographics-and-scale-measures-with-cognitive-driving-behavior-among-older-drivers-in-china
#31
JOURNAL ARTICLE
Bingshuo Chen, Xiaohua Zhao, Yang Li, Xiaoming Liu
Age-related changes and frailty are reasons for the high proportion of older drivers in certain types of crashes, such as giving right of way at intersections and turning left. The identified crash causes include the driver's demographics, driving style, cognitive function, and mental workload. This study aimed to explore the associations of demographics and scale measures with cognitive driving behavior. Thirty-nine drivers, consisting of twenty younger drivers (18-60 years old) and nineteen older drivers (above 60 years old), participated in driving simulation experiments after completing scale tests...
March 18, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38502375/retraction-note-natural-polymer-based-graphene-oxide-bio-nanocomposite-hydrogel-beads-superstructures-with-advanced-potentials-for-drug-delivery
#32
Sadia Rehman, Asadullah Madni, Qazi Adnan Jameel, Faisal Usman, M Rafi Raza, Faiz Ahmad, Hina Shoukat, Hamdan Aali, Afifa Shafiq
No abstract text is available yet for this article.
March 19, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38495124/analysis-of-medicare-patients-treated-with-pimavanserin-versus-other-atypical-antipsychotics-a-cost-offset-model-evaluating-skilled-nursing-facility-stays-and-long-term-care-admissions-in-parkinson-s-disease-psychosis
#33
JOURNAL ARTICLE
Krithika Rajagopalan, Nazia Rashid, Vinod Yakkala, Dilesh Doshi
BACKGROUND: Patients with Parkinson's disease psychosis (PDP) treated with pimavanserin (PIM) versus other atypical antipsychotics (AAPs) including quetiapine (QUE) may have health-care cost savings due to fewer skilled nursing facility-stays (SNF-stays) and long-term care admissions (LTCA). METHODS: A decision analytic model was developed using the 2019 Medicare Patient Driven Payment Model (PDPM) to estimate SNF-stays and LTCA associated per-patient- per-year (PPPY) facility and rehabilitation costs among patients that initiated PIM vs QUE or vs other-AAPs (i...
2024: ClinicoEconomics and Outcomes Research: CEOR
https://read.qxmd.com/read/38494356/crash-causation-countermeasures-and-policy-editorial
#34
EDITORIAL
David Shinar, Ezra Hauer
This editorial is both an introduction to the papers that make up this special issue (on the Relationship between Crash Causation, Countermeasures, and Policy) and an attempt at drawing conclusions. To assist the reader, we begin with a brief description of the subject matter of each paper. As expected, the authors tackle different aspects of this general topic and often differ in their conclusions. We follow up by asking: Are in-depth crash causation studies helpful? Can the need for understanding causation be defended? Does the Swiss Cheese Metaphor require revision? What are the building blocks on which the crash injury prevention programs rest? Can one really avoid comparing costs and benefits? These are some of the issues we raise and discuss...
March 16, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38493612/integrating-visual-factors-in-crash-rate-analysis-at-intersections-an-automl-and-shap-approach-towards-cycling-safety
#35
JOURNAL ARTICLE
Huiyuan Xue, Peizhuo Guo, Yiyan Li, Jun Ma
Cycling crashes constitute a significant and rising share of traffic accidents. Consequently, exploring factors affecting cycling safety has become a priority for both governmental bodies and scholars. However, most existing studies have neglected the vision factors capable of quantitatively describing the city-level cycling environment. Moreover, they have relied on limited models that lack interpretability and fail to capture the spatial variations in the contribution of factors. To address these gaps, this research proposed a framework that used origin-destination-based cycling flow and vision factors generated from Google Street View images to identify the leading factors...
March 16, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38492347/unraveling-the-relation-between-cycling-accidents-and-built-environment-typologies-capturing-spatial-heterogeneity-through-a-latent-class-discrete-outcome-model
#36
JOURNAL ARTICLE
Miguel Costa, Carlos Lima Azevedo, Felix Wilhelm Siebert, Manuel Marques, Filipe Moura
Today, cities seek to transition to more sustainable transportation modes. Cycling is critical in this shift, promoting a more beneficial lifestyle for most. However, cyclists are exposed to many hazardous circumstances or environments, resulting in accidents, injuries, and even death. Transport authorities must understand why accidents occur, to reduce the risk of those who cycle. This study applies a new modeling framework to analyze cycling accident severities. We employ a latent class discrete outcome model, where classes are derived from a Gaussian-Bernoulli mixture, applied to data from Berlin, and augmented with volunteered geographic information...
March 15, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38492346/a-generic-optimization-based-enhancement-method-for-trajectory-data-two-plus-one
#37
JOURNAL ARTICLE
Feng Zhu, Cheng Chang, Zhiheng Li, Boqi Li, Li Li
Trajectory data play a vital role in the field of traffic research such as vehicle safety, traffic flow, and intelligent vehicles. The quality of trajectory data will determine the safety effectiveness of both research and practical applications. Effectively filtering out noise and errors from trajectory data is crucial for improving data quality and further research. However, most enhancement methods only focus on the smoothness of trajectory but overlook abrupt changes. The processed trajectory still exist issues such as incomplete elimination of inconsistency and loss of driving characteristics...
March 15, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38492345/the-role-of-driver-head-pose-dynamics-and-instantaneous-driving-in-safety-critical-events-application-of-computer-vision-in-naturalistic-driving
#38
JOURNAL ARTICLE
Zulqarnain H Khattak, Wan Li, Thomas Karnowski, Asad J Khattak
This paper investigates the role of driver behavior especially head pose dynamics in safety-critical events (SCEs). Using a large dataset collected in a naturalistic driving study, this paper analyzes the head pose dynamics and driving behavior in moments leading up to crashes or near-crashes. The study uses advanced computer vision and mixed logit modeling techniques to identify patterns and relationships between drivers' head pose dynamics and crash involvement. The results suggest that driver-head pose dynamics, especially poses that indicate distraction and movement volatility, are important factors that can contribute to undesirable safety outcomes...
March 15, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38492344/the-immediate-effects-of-vision-zero-corridor-upgrades-on-pedestrian-crashes-in-new-york-a-before-and-after-spatial-point-process-approach
#39
JOURNAL ARTICLE
S Sehtman-Shachar, P C Billig, A Stein, S Kaplan
The long-term effects of the Vision-Zero (VZ) approach in Scandinavia are well documented. In contrast, information regarding the immediate effects of VZ at the starting phase upon gradual implementation is scarce. Taking New York City as the case study, we analyzed both the local and global effects of the Vision-Zero gradual implementation on pedestrian crashes in the early stage of implementation starting from 2014. The data analysis comprised 8,165 pedestrian injury crashes. Using location data, the crashes were matched to VZ infrastructure improvement location, start and completion dates...
March 15, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38490922/road-safety-on-five-continents-2022-conference-papers
#40
EDITORIAL
Anna Vadeby, Stephen Mattingly
No abstract text is available yet for this article.
March 14, 2024: Accident; Analysis and Prevention
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