keyword
https://read.qxmd.com/read/38483326/charge-regulation-at-the-nanoscale-as-evidenced-from-light-responsive-nanoemulsions
#21
JOURNAL ARTICLE
Dana Glikman, Leonard Wyszynski, Valentin Lindfeld, Sebastian Hochstädt, Michael Ryan Hansen, Johannes Neugebauer, Monika Schönhoff, Björn Braunschweig
Emulsions are indispensable in everyday life, and the demand for emulsions' diversity and control of properties is therefore substantial. As emulsions possess a high internal surface area, an understanding of the oil/water (o/w) interfaces at the molecular level is fundamental but often impaired by experimental limitations to probe emulsion interfaces in situ. Here, we have used light-responsive surfactants (butyl-AAP) that can photoisomerize between E and Z isomers by visible and UV light irradiation to tune the emulsion interfaces...
March 14, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38482582/bilirubin-measurement-and-phototherapy-use-after-the-aap-2022-newborn-hyperbilirubinemia-guideline
#22
JOURNAL ARTICLE
Leela Sarathy, Joseph H Chou, Giuseppina Romano-Clarke, Katherine A Darci, Paul H Lerou
BACKGROUND AND OBJECTIVES: Guidelines for the management of neonatal hyperbilirubinemia have helped to reduce rates of significant hyperbilirubinemia. However, recent evidence suggesting overtreatment and potential harms of phototherapy have informed the American Academy of Pediatrics clinical practice guideline revision and the accompanying increase in phototherapy thresholds. These changes are predicted to safely reduce overuse; however, to date, the exact effect of these guidelines has not been established...
March 14, 2024: Pediatrics
https://read.qxmd.com/read/38481144/transcriptome-analysis-reveals-regulatory-mechanisms-of-different-drought-tolerant-gleditsia-sinensis-seedlings-under-drought-stress
#23
JOURNAL ARTICLE
Fuhua Liu, Yang Zhao, Xiurong Wang, Biao Wang, Feng Xiao, Kequan He
BACKGROUND: Gleditsia sinensis is a significant tree species from both ecological and economic perspectives. However, its growth is hampered by temporary droughts during the seedling stage, thereby impeding the development of the G. sinensis industry. Drought stress and rehydration of semi-annual potted seedlings using an artificial simulated water control method. RNA sequencing (RNA-seq) analyses were conducted on leaves collected from highly resistant (HR) and highly susceptible (HS) seedling families at five different stages during the process of drought stress and rehydration to investigate their gene expression patterns...
March 13, 2024: BMC genomic data
https://read.qxmd.com/read/38479204/lateral-safety-evaluation-of-autonomous-trucks-in-overtaking-maneuvers-and-adverse-weather-exploratory-comparison-of-different-lateral-control-modes
#24
JOURNAL ARTICLE
Jilong Chen, Feng Chen, Suiyang Zhao
As the detrimental impact of the commonly recommended centered driving mode for autonomous trucks on road longevity is gaining attention, more lateral control modes are being proposed to enhance road sustainability. However, there is currently a lack of research on the lateral safety analysis of autonomous trucks with different lateral control modes, especially in complex driving scenarios (such as overtaking) and adverse weather conditions. Therefore, this study developed a safety assessment framework to comparatively analyze the risk probability differences in lateral accidents during overtaking maneuvers by autonomous trucks with different lateral control modes under adverse weather conditions...
March 12, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38478197/biodistribution-of-drug-ada-complexes-the-impact-of-immune-complex-formation-on-antibody-distribution
#25
JOURNAL ARTICLE
Eugenia Opolka-Hoffmann, Martin R Edelmann, Michael B Otteneder, Simon Hauri, Gregor Jordan, Peter Schrag, Martin Lechmann, Gerhard Winter, Roland F Staack
The clinical use of therapeutic monoclonal antibodies (mAbs) for the treatment of cancer, inflammation, and other indications has been successfully established. A critical aspect of drug-antibody pharmacokinetics is immunogenicity, which triggers an immune response via an anti-drug antibody (ADA) and forms drug/ADA immune complexes (ICs). As a consequence, there may be a reduced efficacy upon neutralization by ADA or an accelerated drug clearance. It is therefore important to understand immunogenicity in biological therapies...
March 13, 2024: AAPS Journal
https://read.qxmd.com/read/38476806/novel-two-infusion-pump-technique-for-exchange-transfusion-in-a-hyperbilirubinemic-neonate
#26
Naramreddy Sudheesh Reddy, Aditi Rawat, Sagar Karotkar, Ashish Varma, Amar Taksande, Revat J Meshram, Chaitanya Kumar Javvaji, SreeHarsha Damam
Neonatal hyperbilirubinemia is a common concern in newborns, with ABO blood group incompatibility serving as a significant risk factor for severe jaundice. This case report outlines the successful management of a 2.5 kg female infant born to a primigravida mother with ABO incompatibility-induced hyperbilirubinemia. The neonate, born at 38.4 weeks via lower segment cesarean section, exhibited signs of jaundice at 91 hours of life, prompting screening and subsequent confirmation of serum bilirubin levels 26...
February 2024: Curēus
https://read.qxmd.com/read/38472689/fabrication-of-3d-printed-hydrocortisone-triple-pulsatile-tablet-using-fused-deposition-modelling-technology
#27
JOURNAL ARTICLE
Hao Chen, Kai Zheng, Tianshi Bu, Xin Li, Xiangyu Wang, Hao Pan
Hydrocortisone (HC) is the optimal drug for adolescents diagnosed with congenital adrenal hyperplasia (CAH). Because traditional dosage regimens HC are inconvenient, our study used fused deposition modeling (FDM) three-dimensional (3D) printing technology to solve the problems caused by traditional preparations. First, we designed a core-shell structure tablet with an inner instant release component and an outer delayed release shell. The instant release component was Kollicoat IR: glycerol (GLY): HC = 76...
March 12, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38472682/utilization-of-lipophilic-salt-and-phospholipid-complex-in-lipid-based-formulations-to-modulate-drug-loading-and-oral-bioavailability-of-pazopanib
#28
JOURNAL ARTICLE
Karan Jadhav, Arvind Sirvi, Akash Janjal, Mahesh C Kashyap, Abhay T Sangamwar
Pazopanib hydrochloride (PAZ) displays strong intermolecular interaction in its crystal lattice structure, limiting its solubility and dissolution. The development of lipid-based formulations (LbFs) resulted in reduced PAZ loading due to solid-state mediated low liposolubility. This study aims to enhance our understanding of PAZ crystallinity by synthesizing a lipophilic salt and phospholipid complex and investigating its impact on the drug loading in LbFs. The synthesized pazopanib lipophilic salt and phospholipid complex were extensively characterized...
March 12, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38472545/development-of-betulin-loaded-nanostructured-lipid-carriers-for-the-management-of-imiquimod-induced-psoriasis
#29
JOURNAL ARTICLE
Prativa Biswasroy, Deepak Pradhan, Dilip Kumar Pradhan, Goutam Ghosh, Goutam Rath
Psoriasis is a complex and persistent autoimmune skin disease. The present research focused on the therapeutic evaluation of betulin-loaded nanostructured lipid carriers (BE-NLCs) towards managing psoriasis. The BE-NLCs were synthesized using the emulsification cum solidification method, exhibiting a spherical shape with a particle size of 183.5±1.82nm and a narrow size distribution window (PDI: 0.142±0.05). A high zeta potential -38.64±0.05mV signifies the relative stability of the nano-dispersion system...
March 12, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38472523/preclinical-development-of-a-novel-epitope-based-dna-vaccine-candidate-against-sars-cov-2-and-evaluation-of-immunogenicity-in-balb-c-mice
#30
JOURNAL ARTICLE
Kanwal Khalid, Hui Xuan Lim, Ayaz Anwar, Soon Hao Tan, Jung Shan Hwang, Seng-Kai Ong, Chit Laa Poh
The protective efficacies of current licensed vaccines against COVID-19 have significantly reduced as a result of SARS-CoV-2 variants of concern (VOCs) which carried multiple mutations in the Spike (S) protein. Considering that these vaccines were developed based on the S protein of the original SARS-CoV-2 Wuhan strain, we designed a recombinant plasmid DNA vaccine based on highly conserved and immunogenic B and T cell epitopes against SARS-CoV-2 Wuhan strain and the Omicron VOC...
March 12, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38471237/on-the-impact-of-on-road-partially-automated-driving-on-drivers-cognitive-workload-and-attention-allocation
#31
JOURNAL ARTICLE
Francesco N Biondi, Noor Jajo
The use of partially-automated or SAE level-2 vehicles is expected to change the role of the human driver from operator to supervisor, which may have an effect on the driver's workload and visual attention. In this study, 30 Ontario drivers operated a vehicle in manual and partially-automated mode. Cognitive workload was measured by means of the Detection Response Task, and visual attention was measured by means of coding glances on and off the forward roadway. No difference in cognitive workload was found between driving modes...
March 11, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38471236/development-and-classification-of-autonomous-vehicle-s-ambiguous-driving-scenario
#32
JOURNAL ARTICLE
Tiju Baby, Hatice Şahin Ippoliti, Philipp Wintersberger, Yiqi Zhang, Sol Hee Yoon, Jieun Lee, Seul Chan Lee
Human drivers are gradually being replaced by highly automated driving systems, and this trend is expected to persist. The response of autonomous vehicles to Ambiguous Driving Scenarios (ADS) is crucial for legal and safety reasons. Our research focuses on establishing a robust framework for developing ADS in autonomous vehicles and classifying them based on AV user perceptions. To achieve this, we conducted extensive literature reviews, in-depth interviews with industry experts, a comprehensive questionnaire survey, and factor analysis...
March 11, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38471235/heterogeneity-in-crash-data-a-cross-comparison-between-ordered-probability-model-and-its-variant-using-crashes-at-suburban-type-arterial
#33
JOURNAL ARTICLE
Bedan Khanal, Anahita Zahertar, Steven Lavrenz
Transportation researchers have long been using the statistical analysis of traffic crash data to create a proactive awareness of traffic safety, make important decisions about the design of vehicles and highways, and develop and implement safe preventive strategies to improve safety. Despite significant progress toward maintaining and analyzing traffic crash data, researchers still encounter several challenges and methodological barriers when conducting statistical analysis. One of these challenges is dealing with the issue of unobserved heterogeneity in crash data...
March 11, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38470161/constructing-heptazine-cof-tio-2-heterojunction-photocatalysts-for-efficient-photodegradation-of-acetaminophen-under-visible-light
#34
JOURNAL ARTICLE
Shijie Ge, Yixiao Cai, Lili Deng, Mengtian Jin, Xiangyang Qu, He Liu, Huaping Wang, Biao Wang
Constructing heterojunction photocatalysts are widely applied to boost the photocatalytic activity of materials. Here, a novel covalent organic framework (COF) material with heptazine units was developed and hybridized with TiO2 nano particles (NPs) to fabricate the Heptazine-COF@TiO2 photocatalysts for acetaminophen (AAP) photodegradation. The successfully assembled heptazine unit endows the Heptazine-COF with outstanding semiconductor property (optical bandgap is 2.53 eV). The synthesized Heptazine-COF@TiO2 hybrids is proved to have the heterojunction structure with high visible light activity and fast charge-carrier mobility, and exhibits better performance in photodegradation of AAP under visible light...
February 27, 2024: ChemPlusChem
https://read.qxmd.com/read/38460338/effects-of-road-width-radii-and-speeds-on-collisions-at-three-arm-priority-intersections
#35
JOURNAL ARTICLE
Mustafa Ekmekci, Lee Woods, Nima Dadashzadeh
Simulation and observational studies have identified the importance of intersection geometries and vehicle speeds in collisions. However, the causal mechanisms of such collisions in low-speed areas and for different collision types remain unclear. This observational study investigates the complex relationships between geometries, speeds, visibilities, and road traffic collisions in the context of low-speed urban areas.Data were collected from 120 three-arm priority intersections in Portsmouth, UK. In 2007, Portsmouth became the first city in the UK to adopt a 20mph speed limit on all residential streets...
March 8, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38460074/the-relation-of-maternal-psychosocial-risk-factors-to-infant-safe-sleep-practices
#36
JOURNAL ARTICLE
Kalani Gates, Summer Chahin, Amy Damashek, Cheryl Dickson, Grace Lubwama, Debra Lenz, Terra Bautista, Catherine Kothari
OBJECTIVES: Sleep-related infant deaths are a common and preventable cause of infant mortality in the United States. Moreover, infants of color are at a greater risk of sleep-related deaths than are White infants. The American Academy of Pediatrics (AAP) published safe sleep guidelines to minimize the number of sleep-related infant deaths; however, many families face barriers to following these guidelines. Research on the role of psychosocial risk factors (i.e., depression, stress, domestic violence, substance use) in mothers' engagement in safe sleep practices is limited...
March 9, 2024: Maternal and Child Health Journal
https://read.qxmd.com/read/38459151/quality-by-design-framework-applied-to-gmma-purification
#37
JOURNAL ARTICLE
Carlo Giannelli, Francesca Necchi, Elena Palmieri, Davide Oldrini, Beatrice Ricchetti, Maria M Papathanasiou, Zoltan Kis, Cleo Kontoravdi, Cristiana Campa, Francesca Micoli
In recent years, Generalized Modules for Membrane Antigens (GMMA) have received increased attention as an innovative vaccine platform against bacterial pathogens, particularly attractive for low- and middle-income countries because of manufacturing simplicity. The assessment of critical quality attributes (CQAs), product-process interactions, identification of appropriate in process analytical methods, and process modeling is part of a robust quality by design (QbD) framework to support further development and control of manufacturing processes...
March 8, 2024: AAPS Journal
https://read.qxmd.com/read/38458009/assessing-the-negative-binomial-lindley-model-for-crash-hotspot-identification-insights-from-monte-carlo-simulation-analysis
#38
JOURNAL ARTICLE
Jhan Kevin Gil-Marin, Mohammadali Shirazi, John N Ivan
Identifying hazardous crash sites (or hotspots) is a crucial step in highway safety management. The Negative Binomial (NB) model is the most common model used in safety analyses and evaluations - including hotspot identification. The NB model, however, is not without limitations. In fact, this model does not perform well when data are highly dispersed, include excess zero observations, or have a long tail. Recently, the Negative Binomial-Lindley (NB-L) model has been proposed as an alternative to the NB. The NB-L model overcomes several limitations related to the NB, such as addressing the issue of excess zero observations in highly dispersed data...
March 7, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38458008/a-systematic-review-of-the-use-of-in-vehicle-telematics-in-monitoring-driving-behaviours
#39
JOURNAL ARTICLE
James Boylan, Denny Meyer, Won Sun Chen
BACKGROUND: Road traffic deaths are increasing globally, and preventable driving behaviours are a significant cause of these deaths. In-vehicle telematics has been seen as technology that can improve driving behaviour. The technology has been adopted by many insurance companies to track the behaviours of their consumers. This systematic review presents a summary of the ways that in-vehicle telematics has been modelled and analysed. METHODOLOGY: Electronic searches were conducted on Scopus and Web of Science...
March 7, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38457329/prevalence-of-chronic-urticaria-a-study-in-the-pediatric-population-of-a-general-hospital
#40
JOURNAL ARTICLE
Andrea Correa Acosta, Claudio A S Parisi, Natalia Petriz
Introduction. Chronic urticaria is an inflammatory skin condition characterized by the presence of evanescent wheals or angioedema that last for ≥ 6 weeks. Objective. To determine the prevalence of urticaria and describe its clinical characteristics in children and adolescents under 19 years of age in a general hospital. Population and methods. This was a cross-sectional study carried out between 2015 and 2020 in a population of children and adolescents seen at a private healthcare facility. Results...
March 14, 2024: Archivos Argentinos de Pediatría
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