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https://www.readbyqxmd.com/read/29893627/practices-attitudes-and-beliefs-of-palliative-care-physicians-regarding-the-use-of-methadone-and-other-long-acting-opioids-in-children-with-advanced-cancer
#1
Kevin Madden, Minjeong Park, Diane Liu, Eduardo Bruera
BACKGROUND: Palliative care physicians often assist with pain management in children with cancer, but little is known about how they use long-acting opioids for chronic pain with these patients. OBJECTIVE: To determine the practices, attitudes, and beliefs of palliative care physicians toward the use of long-acting opioids in children with advanced cancer. DESIGN: An electronic survey was sent to all members of The American Academy of Pediatrics (AAP) Section of Hospice and Palliative Medicine (SOHPM) and those identified as physicians who provide palliative care to children on the AAP SOHPM LISTSERV® ...
June 12, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29883982/variability-in-immunization-practices-for-preterm-infants
#2
Srirupa Hari Gopal, Kathryn M Edwards, Buddy Creech, Joern-Hendrik Weitkamp
INTRODUCTION:  The Advisory Committee on Immunization Practices and the American Academy of Pediatrics (AAP) recommend the same immunization schedule for preterm and term infants. However, significant delays in vaccination of premature infants have been reported. OBJECTIVE:  The objective of this study was to assess the variability of immunization practices in preterm infants. STUDY DESIGN:  We conducted an online survey of 2,443 neonatologists in the United States, who are members of the Section for Neonatal-Perinatal Medicine of the AAP...
June 8, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29880237/assessing-the-recent-estimates-of-the-global-burden-of-disease-for-ambient-air-pollution-methodological-changes-and-implications-for-low-and-middle-income-countries
#3
REVIEW
Bart Ostro, Joseph V Spadaro, Sophie Gumy, Pierpaolo Mudu, Yewande Awe, Francesco Forastiere, Annette Peters
The Global Burden of Disease (GBD) is a comparative assessment of the health impact of the major and well-established risk factors, including ambient air pollution (AAP) assessed by concentrations of PM2.5 (particles less than 2.5 µm) and ozone. Over the last two decades, major improvements have emerged for two important inputs in the methodology for estimating the impacts of PM2.5: the assessment of global exposure to PM2.5 and the development of integrated exposure risk models (IERs) that relate the entire range of global exposures of PM2...
June 4, 2018: Environmental Research
https://www.readbyqxmd.com/read/29870136/guidelines-and-checklists-for-short-term-missions-in-global-pediatric-surgery-recommendations-from-the-american-academy-of-pediatrics-delivery-of-surgical-care-global-health-subcommittee-american-pediatric-surgical-association-global-pediatric-surgery-committee
#4
Marilyn Butler, Elizabeth Drum, Faye M Evans, Tamara Fitzgerald, Jason Fraser, Ai-Xuan Holterman, Howard Jen, Matthew Kynes, Jenny Kreiss, Craig D McClain, Mark Newton, Benedict Nwomeh, James O'Neill, Doruk Ozgediz, George Politis, Henry Rice, David Rothstein, Julie Sanchez, Mark Singleton, Francine S Yudkowitz
Pediatric surgeons, anesthesia providers, and nurses from North America and other high-income countries are increasingly engaged in resource-limited areas, with short-term missions as the most common form of involvement. However, consensus recommendations currently do not exist for short-term missions in pediatric general surgery and associated perioperative care. The American Academy of Pediatrics (AAP) Delivery of Surgical Care Subcommittee and American Pediatric Surgical Association (APSA) Global Pediatric Surgery Committee, with the American Pediatric Surgical Nurses Association, Inc...
May 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29862860/changes-in-healthcare-resource-use-and-costs-associated-with-early-versus-delayed-initiation-of-atypical-antipsychotic-adjunctive-treatment-in-major-depressive-disorder
#5
Arpamas Seetasith, Mallik Greene, Ann Hartry, Chakkarin Burudpakdee
AIMS: The study compared all-cause and major depressive disorder (MDD)-related healthcare resource use (HRU) and costs in patients with MDD treated with atypical antipsychotic (AAP) adjunctive therapy early or later in treatment. MATERIALS AND METHODS: Adults with MDD and antidepressant treatment (ADT) who newly initiated adjunctive aripiprazole, brexpiprazole, lurasidone, or quetiapine between October 1, 2014 and September 30, 2015 were identified in IQVIA Real-World Data Adjudicated Claims database; the index date was the date of the first AAP claim...
June 2, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29842951/effect-of-solution-plasma-process-with-hydrogen-peroxide-on-the-degradation-and-antioxidant-activity-of-polysaccharide-from-auricularia-auricula
#6
Jingwei Wu, Pu Li, Haitian Zhao, Renyan Sun, Fengming Ma, Baiqing Zhang
Solution plasma process (SPP) in combination with hydrogen peroxide (H2 O2 ) were adopted to the degradation of Auricularia auricula polysaccharide (AAP). The results showed that SPP irradiation with H2 O2 was effective for the AAP degradation. The intrinsic viscosity ([η]) of AAP solution decreased exponentially with increase in irradiation time. The degradation reaction closely fitted to the first order kinetics. The degradation rate constant after SPP irradiation with H2 O2 was approximately 4.2 times that with SPP irradiation alone...
May 26, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29806806/propofol-administration-by-endoscopists-versus-anesthesiologists-in-gastrointestinal-endoscopy-a-systematic-review-and-meta-analysis-of-patient-safety-outcomes
#7
Julian F Daza, Carolyn M Tan, Ryan J Fielding, Allison Brown, Forough Farrokhyar, Ilun Yang
BACKGROUND: With a growing demand for endoscopic services, the role of anesthesiologists in endoscopy units must be reassessed. The aim of this study was to compare patient outcomes in non-anesthesiologist-administered propofol (NAAP) versus anesthesiologist-administered propofol (AAP) during routine endoscopy. METHODS: We systematically searched Medline, CINAHL, Embase, Web of Science, CENTRAL and the grey literature for studies comparing NAAP and AAP. Primary outcomes included endoscopy- and sedation-related complications...
June 1, 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29799035/carboxylic-and-o-acetyl-moieties-are-essential-for-the-immunostimulatory-activity-of-glucuronoxylomannan-a-novel-tlr4-specific-immunostimulator-from-auricularia-auricula-judae
#8
Namal Perera, Feng-Ling Yang, Jeffy Chern, Hsiao-Wen Chiu, Chih-Yu Hsieh, Lan-Hui Li, Yan-Long Zhang, Kuo-Feng Hua, Shih-Hsiung Wu
This study established the comprehensive repeating unit structure of immunologically active glucuronoxylomannan (AAPS) from wood ear mushroom, Auricularia auricula-judae. We identified Toll-like receptor 4 (TLR4) as a critical receptor involved in AAPS-induced macrophage activation to secrete pro-inflammatory cytokines. Molecular modeling data and chemical modifications of AAPS revealed that both carboxylic and acetyl moieties of AAPS are equally essential in TLR4 binding to exert in vitro immunostimulatory activity...
May 25, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29798734/metabolic-side-effects-of-atypical-antipsychotics-in-older-adults
#9
Emme Chacko, Stephen Boyd, Rinki Murphy
ABSTRACTBackground:The atypical antipsychotics (AAPs) are associated with a recognized class effect of glucose and lipid dysregulation. The use of these medications is rapidly increasing in elderly patients with, and without, dementia. However, the metabolic risks specific to elderly remain poorly studied. METHODS: Design: A case-control study. SETTING: Psychogeriatric service in Auckland, New Zealand. PARTICIPANTS: Elderly patients either receiving AAP treatment (cases) or not (controls) between 1 Jan 2008 and 1 Jan 2014...
May 25, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29794908/unsafe-firearm-storage-in-homes-with-children
#10
Elizabeth Mechcatie
Only about one-third follow AAP safety guidelines.
June 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29788164/what-is-the-optimal-systemic-treatment-of-men-with-metastatic-hormone-naive-prostate-cancer-a-stopcap-systematic-review-and-network-meta-analysis
#11
C L Vale, D J Fisher, I R White, J R Carpenter, S Burdett, N W Clarke, K Fizazi, G Gravis, N D James, M D Mason, M K B Parmar, L H Rydzewska, C J Sweeney, M R Spears, M R Sydes, J F Tierney
Background: Our prior Systemic Treatment Options for Cancer of the Prostate systematic reviews showed improved survival for men with metastatic hormone-naive prostate cancer when abiraterone acetate plus prednisolone/prednisone (AAP) or docetaxel (Doc), but not zoledronic acid (ZA), were added to androgen-deprivation therapy (ADT). Trial evidence also suggests a benefit of combining celecoxib (Cel) with ZA and ADT. To establish the optimal treatments, a network meta-analysis (NMA) was carried out based on aggregate data (AD) from all available studies...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29781242/photo-controlled-reversible-microtubule-assembly-mediated-by-cyclodextrin-derivative
#12
Ying-Ming Zhang, Ni-Yuan Zhang, Kui Xiao, Yu Liu, Qilin Yu
The design and construction of multistimuli-responsive supramolecular nanoassemblies that can mimic and regulate the fundamental biological processes has become a focus of interest in supramolecular chemistry. In this work, a perfect combination has been achieved between naturally occurring microtubule and artificially macrocyclic receptor. The self-assembling morphology of microtubules can be photo-tuned by the host-guest interaction of paclitaxel-modified β-cyclodextrin (PTX-CD) and photochromic arylazopyrazole (PTX-AAP)...
May 20, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29779714/self-monitoring-induced-savings-on-type-2-diabetes-patients-travel-and-healthcare-costs
#13
Aapeli Leminen, Markku Tykkyläinen, Tiina Laatikainen
BACKGROUND: Type 2 diabetes (T2DM) is a major health concern in most regions. In addition to direct healthcare costs, diabetes causes many indirect costs that are often ignored in economic analyses. Patients' travel and time costs associated with the follow-up of T2DM patients have not been previously calculated systematically over an entire healthcare district. The aim of the study was to develop a georeferenced cost model that could be used to measure healthcare accessibility and patient travel and time costs in a sparsely populated healthcare district in Finland...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29779259/periodontal-status-among-elderly-inhabitants-of-northern-manhattan-the-whicap-ancillary-study-of-oral-health
#14
Jaffer A Shariff, Sandra Burkett, Caitlin Wei-Ming Watson, Bin Cheng, James M Noble, Panos N Papapanou
AIM: We conducted a cross-sectional study of the prevalence, extent and severity of periodontitis in a tri-ethnic cohort of ≥65 year-old participants of the Washington-Heights Inwood Community Aging Project (WHICAP). METHODS: 1,130 individuals (57% of eligible invitees) participated in a full-mouth periodontal examination that included assessments of bleeding on probing, pocket depth and clinical attachment loss (CAL) at six sites/tooth. RESULTS: Participants had a mean age of 75...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29777781/screen-related-parenting-practices-in-low-income-mexican-american-families
#15
Darcy A Thompson, Sarah J Schmiege, Susan L Johnson, Elizabeth A Vandewater, Richard E Boles, Ruth E Zambrana, Jerusha Lev, Jeanne M Tschann
OBJECTIVES: To (1) examine whether the Information, Motivation, and Behavioral Skills Model predicts maternal screen-related parenting practices and (2) evaluate the relationship of American Academy of Pediatrics(AAP)-recommended parenting practices with child television (TV) use behaviors. METHODS: In this cross-sectional study, 312 Spanish- and/or English-speaking female primary caregivers of Mexican descent with a child 3-5 years of age were recruited from safety-net pediatric clinics...
May 16, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29768578/-work-accidents-and-automatic-circuit-reclosers-in-the-electricity-sector-beyond-the-immediate-causes
#16
Alessandro Jose Nunes da Silva, Ildeberto Muniz de Almeida, Rodolfo Andrade de Gouveia Vilela, Renata Wey Berti Mendes, Sandra Lorena Beltran Hurtado
The Brazilian electricity sector has recorded high work-related mortality rates that have been associated with outsourcing, used to cut costs. In order to decrease the power outage time for consumers, the industry adopted the automatic circuit recloser as the technical solution. The device has hazardous implications for maintenance workers. The aim of this study was to analyze the origins and consequences of work accidents in power systems with automatic circuit recloser, using the Accident Analysis and Prevention (AAP) model...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29764238/successful-administration-of-bi-695501-an-adalimumab-biosimilar-using-an-autoinjector-ai-results-from-a-phase-ii-open-label-clinical-study-voltaire-%C3%A2-rl
#17
Stanley Cohen, Piotr A Klimiuk, Tillmann Krahnke, Deepak Assudani
BACKGROUND: This study examined the patient handling experience and self-injection success of patients with rheumatoid arthritis (RA) administering BI 695501 using an AI. METHODS: This Phase II, 7-week, open-label, interventional study (NCT02636907) included adult patients with moderately to severely active RA not adequately controlled by DMARDs, with no experience of self-injecting with AI/pen. Patients self-injected BI 695501 via AI every 2 weeks in the AI Assessment Period (AAP)...
May 15, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29757842/asthma-action-plans-in-the-adult-population-rediscovering-an-invaluable-tool-in-today-s-health-care-domain
#18
Jack Mayeux, Krysten Lisella Arekapudi, Azita Amiri
BACKGROUND AND PURPOSE: Asthma in adults remains a leading cause of morbidity, mortality, and increased health care costs. Asthma action plans (AAPs) have demonstrated improved health outcomes in this populace; however, AAPs continue to be underused by providers. This article aims to re-emphasize the importance of AAPs for adults and refresh providers on the effectiveness and methods to use this indispensable tool. METHODS: A literature search of MEDLINE, PubMed, Google Scholar, and CINAHL was performed, and subsequent findings were reported...
May 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29742436/the-assembly-activating-protein-promotes-stability-and-interactions-between-aav-s-viral-proteins-to-nucleate-capsid-assembly
#19
Anna C Maurer, Simon Pacouret, Ana Karla Cepeda Diaz, Jessica Blake, Eva Andres-Mateos, Luk H Vandenberghe
The adeno-associated virus (AAV) vector is a preferred delivery platform for in vivo gene therapy. Natural and engineered variations of the AAV capsid affect a plurality of phenotypes relevant to gene therapy, including vector production and host tropism. Fundamental to these aspects is the mechanism of AAV capsid assembly. Here, the role of the viral co-factor assembly-activating protein (AAP) was evaluated in 12 naturally occurring AAVs and 9 putative ancestral capsid intermediates. The results demonstrate increased capsid protein stability and VP-VP interactions in the presence of AAP...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29741721/update-from-the-advisory-committee-on-immunization-practices
#20
Sean T O'Leary, David W Kimberlin, Yvonne A Maldonado
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. The ACIP met on October 25 and 26, 2017, to discuss herpes zoster vaccine, the child/adolescent and adult vaccination schedules, Japanese encephalitis (JE) epidemiology and vaccines, pneumococcal vaccines, anthrax vaccines and disaster preparedness, hepatitis A outbreaks, influenza surveillance and vaccination coverage, vaccine safety, and considerations for a potential third dose of measles-mumps-rubella (MMR) vaccine to combat ongoing mumps outbreaks...
May 15, 2018: Journal of the Pediatric Infectious Diseases Society
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