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https://www.readbyqxmd.com/read/28535139/otitis-media-with-effusion-our-national-practice
#1
Rachel E Roditi, Richard M Rosenfeld, Jennifer J Shin
Otitis media with effusion (OME) is the focus of an updated multidisciplinary clinical practice guideline published by the American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) and the American Academy of Pediatrics (AAP). Based on data from clinical trials, the guideline recommends against using antihistamines, antibiotics, oral steroids, and intranasal steroids for OME. To understand practice patterns related to these guidelines, we assessed nationally representative data. Despite controlling for age, sex, race/ethnicity, and other potential confounders individualized for each medication class, an increased risk of antihistamine (odds ratio [OR], 3...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28534877/light-enhances-the-growth-rates-of-natural-populations-of-aerobic-anoxygenic-phototrophic-bacteria
#2
Isabel Ferrera, Olga Sánchez, Eva Kolářová, Michal Koblížek, Josep M Gasol
Aerobic anoxygenic phototrophic (AAP) bacteria are microorganisms that can harvest light energy using bacteriochlorophyll a to supplement their predominantly organotrophic metabolism. Growth enhancement by light has repeatedly been demonstrated in laboratory experiments with AAP isolates. However, the ecological advantage of light utilization is unclear, as it has never been proven in the natural environment. Here, we conducted manipulation experiments in the NW Mediterranean and found that AAP bacteria display high growth rates which are controlled to a large extent by intense grazing pressure and phosphorous availability...
May 23, 2017: ISME Journal
https://www.readbyqxmd.com/read/28491057/identification-of-genes-controlled-by-the-essential-yycfg-two-component-system-reveals-a-role-for-biofilm-modulation-in-staphylococcus-epidermidis
#3
Tao Xu, Yang Wu, Zhiwei Lin, Ralph Bertram, Friedrich Götz, Ying Zhang, Di Qu
Biofilms play a crucial role in the pathogenicity of Staphylococcus epidermidis, while little is known about whether the essential YycFG two-component signal transduction system (TCS) is involved in biofilm formation. We used antisense RNA (asRNA) to silence the yycFG TCS in order to study its regulatory functions in S. epidermidis. Strain 1457 expressing asRNA yycF exhibited a significant delay (~4-5 h) in entry to log phase, which was partially complemented by overexpressing ssaA. The expression of asRNA yycF and asRNA yycG resulted in a 68 and 50% decrease in biofilm formation at 6 h, respectively, while they had no significant inhibitory effect on 12 h biofilm formation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28483249/effect-of-gentamicin-and-levels-of-ambient-sound-on-hearing-screening-outcomes-in-the-neonatal-intensive-care-unit-a-pilot-study
#4
Angela C Garinis, Selena Liao, Campbell P Cross, Johnathan Galati, Jessica L Middaugh, Jess C Mace, Anna-Marie Wood, Lindsey McEvoy, Lauren Moneta, Troy Lubianski, Noe Coopersmith, Nicholas Vigo, Christopher Hart, Artur Riddle, Olivia Ettinger, Casey Nold, Heather Durham, Carol MacArthur, Cynthia McEvoy, Peter S Steyger
OBJECTIVE: Hearing loss rates in infants admitted to neonatal intensive care units (NICU) run at 2-15%, compared to 0.3% in full-term births. The etiology of this difference remains poorly understood. We examined whether the level of ambient sound and/or cumulative gentamicin (an aminoglycoside) exposure affect NICU hearing screening results, as either exposure can cause acquired, permanent hearing loss. We hypothesized that higher levels of ambient sound in the NICU, and/or gentamicin dosing, increase the risk of referral on the distortion product otoacoustic emission (DPOAE) assessments and/or automated auditory brainstem response (AABR) screens...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28477430/sound-levels-in-a-neonatal-intensive-care-unit-significantly-exceeded-recommendations-especially-inside-incubators
#5
J Parra, A de Suremain, F Berne Audeoud, A Ego, T Debillon
AIM: This study measured sound levels in a 2008 built French neonatal intensive care unit (NICU) and compared them to the 2007 American Academy of Pediatrics (AAP) recommendations. The ultimate aim was to identify factors that could influence noise levels. METHODS: The study measured sound in 17 single or double rooms in the NICU. Two dosimeters were installed in each room, one inside and one outside the incubators, and these conducted measurements over a 24-hour period...
May 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28474733/practitioner-review-the-effects-of-atypical-antipsychotics-and-mood-stabilisers-in-the-treatment-of-depressive-symptoms-in-paediatric-bipolar-disorder
#6
REVIEW
Tobias Atkin, Nicolas Nuñez, Gabriella Gobbi
BACKGROUND: The management of depressive and mixed symptoms in children and adolescents with bipolar disorder (BD) remains a matter of debate. The goal of this review is, thus, to systematically examine the impact of atypical antipsychotics (AAPs) and mood stabilisers in the treatment of bipolar depression and/or mixed states. METHODS: A literature search was conducted for studies assessing the efficacy of pharmacological treatments for bipolar disorder type I, type II and not otherwise specified with a recent depressive, mixed or manic episode (with depressive symptoms) following DSM-IV criteria in children and adolescents as either acute or maintenance treatment...
May 5, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28461295/an-evidence-based-point-of-care-tool-to%C3%A2-guide-completion-of-asthma-action-plans%C3%A2-in-practice
#7
Andrew Kouri, Louis-Philippe Boulet, Alan Kaplan, Samir Gupta
Asthma action plans (AAPs) reduce healthcare utilisation, improve quality of life and are recommended across guidelines. However, fewer than 25% of patients receive an AAP, partly due to prescribers' inability to complete "yellow zone" instructions (how to intensify therapy for acute loss of control). We sought to review best evidence to develop a practical, evidence-based tool to facilitate yellow zone guidance in adults.We reviewed recent asthma guidelines and adult studies addressing acute loss of asthma control (January 2010 to March 2016)...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28458547/peroxidase-like-activity-of-nanocrystalline-cobalt-selenide-and-its-application-for-uric-acid-detection
#8
Quan-Quan Zhuang, Zhi-Hang Lin, Yan-Cheng Jiang, Hao-Hua Deng, Shao-Bin He, Li-Ting Su, Xiao-Qiong Shi, Wei Chen
Dendrite-like cobalt selenide nanostructures were synthesized from cobalt and selenium powder precursors by a solvothermal method in anhydrous ethylenediamine. The as-prepared nanocrystalline cobalt selenide was found to possess peroxidase-like activity that could catalyze the reaction of peroxidase substrates in the presence of H2O2. A spectrophotometric method for uric acid (UA) determination was developed based on the nanocrystalline cobalt selenide-catalyzed coupling reaction between N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt and 4-aminoantipyrine (4-AAP) in the presence of H2O2...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28456713/breathing-changes-accompanying-balance-improvement-during-biofeedback
#9
Zuzana Hirjaková, Kateřina Neumannová, Jana Kimijanová, Kristína Šuttová, Miroslav Janura, František Hlavačka
The aim of this study was to determine whether respiration would be altered during visual biofeedback condition while standing on a foam surface. Fifty young, healthy subjects (24 men, 26 women) were divided into a spirometry group, in which additional spirometry analysis was performed, and a control group. All subjects were tested in two conditions: 1) standing on a foam surface and 2) standing on a foam surface with visual biofeedback (VF) based on the centre of pressure (CoP). CoP amplitude and velocity in anterior-posterior (Aap, Vap) and medial-lateral (Aml, Vml) directions were measured by the force platform...
April 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28453378/effectiveness-of-written-action-plans-for-acute-asthma-a-systematic-review
#10
Cristina Villa-Roel, Britt Voaklander, Maria B Ospina, Taylor Nikel, Sandra Campbell, Brian H Rowe
OBJECTIVE: Self-management is an essential part of achieving asthma control and improving long-term outcomes. While guidelines recommend the provision of written asthma action plans (AAPs), few patients presenting to emergency departments (ED) have one. This systematic review examined if individualized written AAPs reduce relapses in adults following an ED visit for acute asthma. DATA SOURCES: Comprehensive searches of seven electronic databases and grey literature were conducted...
April 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28452891/child-seat-belt-guidelines-examining-the-4-9-rule-as-the-standard-examining-the-4-9-rule-as-the-standard
#11
Amber M Morse, Mary E Aitken, Samantha H Mullins, Beverly K Miller, Mindy M Pomtree, Erin M Ulloa, Jeffrey S Montgomery, Marie E Saylors
BACKGROUND: Current American Academy of Pediatrics (AAP) recommendations regarding transition from child safety/booster seat to adult safety belt use indicate that children should be at least 4'9", 8 years old, or 80 pounds. Proper fit in the vehicle seat, assessed with a 5 point fit test, should also be met. While most children reach 4'9" around age 8, each child and vehicle presents a unique combination; thus a child may not fit appropriately in all vehicle types using only the 4'9" requirement...
April 27, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28450082/a-randomized-trial-of-a-children-s-book-versus-brochures-for-safe-sleep-knowledge-and-adherence-in-a-high-risk-population
#12
John S Hutton, Resmi Gupta, Rachel Gruber, Jennifer Berndsen, Thomas DeWitt, Nicholas J Ollberding, Judith B Van Ginkel, Robert T Ammerman
BACKGROUND: Sleep-related infant deaths have plateaued in the past decade, disproportionately affecting low-socio-economic-status (SES) families. Printed materials are widely used for anticipatory guidance, yet none for safe sleep have been studied. OBJECTIVES: To test the efficacy of a specially designed children's book compared to brochures for safe sleep knowledge and adherence, which we hypothesized would be greater due to superior readability and engagement...
April 24, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28447866/which-fecal-immunochemical-test-should-i-choose
#13
Jeanette M Daly, Yinghui Xu, Barcey T Levy
OBJECTIVES: To summarize the fecal immunochemical tests (FITs) available in the United States, the 2014 pathology proficiency testing (PT) program FIT results, and the literature related to the test characteristics of FITs available in the United States to detect advanced adenomatous polyps (AAP) and/or colorectal cancer (CRC). METHODS: Detailed review of the Food and Drug Administration's Clinical Laboratory Improvement Amendments (CLIA) database of fecal occult blood tests, the 2014 FIT PT program results, and the literature related to FIT accuracy...
April 1, 2017: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/28441418/relationship-between-acromial-morphological-variation-and-subacromial-impingement-a-three-dimensional-analysis
#14
Xinyu Li, Wei Xu, Ning Hu, Xi Liang, Wei Huang, Dianming Jiang, Hong Chen
PURPOSE: To evaluate the association of acromial morphology and subacromial impingement. METHODS: Bilateral shoulder computed tomography was performed in 138 patients who received shoulder arthroscopy. Measured parameters included: acromial tilt (AT), modified acromial tilt (mAT), acromial slope (AS), acromiohumeral interval (AHI), lateral acromial angle (LAA), acromial index (AI), critical shoulder angle (CSA), acromial anterior protrusion (AAP), and acromial inferior protrusion (AIP)...
2017: PloS One
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#15
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28430936/preliminary-evaluation-of-the-niaaa-aap-brief-alcohol-use-screener
#16
Alan Meca, Jonathan G Tubman, Timothy Regan, Diane D Zheng, Rhoda Moise, Tae Kyoung Lee, Mary H Soares, Maria R Velazquez, Andrew Egbert, Seth J Schwartz
Aims: To assess the concurrent validity of the two-item NIAAA/American Academy of Pediatrics Brief Alcohol Use Screener, a developmentally sensitive assessment instrument, in a school-based sample of adolescents. Method: The sample consisted of 756 adolescents (53% girls; Mage = 13.7 years; SD = 1.6 years) in the 6th (n = 192), 8th (n = 283), and the 10th (n = 281) grades from Miami-Dade County, FL and Prince George's County, MD. Adolescents completed the NIAAA/AAP Brief Alcohol Use Screener, which consists of two items asking about adolescents' alcohol use and about peers' alcohol use during the last year...
May 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28428097/care-coordination-and-comprehensive-electronic-health-records-are-associated-with-increased-transition-planning-activities
#17
Niraj Sharma, Kitty O'Hare, Karen G O'Connor, Umbereen Nehal, Megumi J Okumura
OBJECTIVE: Youth with Special Health Care Needs (YSHCN) require assistance from their pediatricians to transition to adult care. There is little data on what transition resources pediatricians have. This paper studies if care coordination and/or comprehensive electronic health record (CEHR) implementation are associated with improved transition processes. METHODS: Using AAP Periodic Survey #79, we report whether practices generated written transition plans, assisted in finding adult providers, and discussed confidentiality issues...
April 18, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28419179/the-intensity-of-brief-interventions-in-patients-with-acute-alcoholic-pancreatitis-should-be-increased-especially-in-young-patients-with-heavy-alcohol-consumption
#18
Jussi Nikkola, Johanna Laukkarinen, Heini Huhtala, Juhani Sand
Aims: After the first acute alcoholic pancreatitis (AAP), active repeated brief interventions (BIs) have been shown to protect against recurrent acute pancreatitis (RAP). However, in daily hospital practice the treatment of alcohol problems varies. Our aim was to study BIs performed in the clinic during AAP and whether this prevents from future RAP episodes. Methods: Data on all patients discharged between 10/2010 and 10/2012 with acute pancreatitis as the primary diagnosis were obtained from the hospital database...
April 13, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28419115/properties-of-the-cuticular-proteins-of-anopheles-gambiae-as-revealed-by-serial-extraction-of-adults
#19
Yihong Zhou, Majors J Badgett, Lynne Billard, John Hunter Bowen, Ron Orlando, Judith H Willis
How cuticular proteins (CPs) interact with chitin and with each other in the cuticle remains unresolved. We employed LC-MS/MS to identify CPs from 5-6 day-old adults of Anopheles gambiae released after serial extraction with PBS, EDTA, 2-8M urea, and SDS as well as those that remained unextracted. Results were compared to published data on time of transcript abundance, localization of proteins within structures and within the cuticle, as well as properties of individual proteins, length, pI, percent histidine, tyrosine, glutamine, and number of AAP[A/V/L] repeats...
2017: PloS One
https://www.readbyqxmd.com/read/28400304/parent-preferences-and-perceptions-of-mls-and-teaspoons-role-of-health-literacy-and-experience
#20
Alejandro Torres, Ruth M Parker, Lee M Sanders, Michael S Wolf, Stacy Bailey, Deesha A Patel, Jessica J Jimenez, Kwang-Youn A Kim, Benard P Dreyer, Alan Mendelsohn, H Shonna Yin
BACKGROUND AND OBJECTIVES: A recent AAP policy statement recommends mL-exclusive dosing for pediatric liquid medications. Little is known about parent preferences regarding units, perceptions about moving to mL-only, and the role of health literacy and prior mL-dosing experience. METHODS: Cross-sectional analysis of data collected as part of a randomized controlled study in 3 urban pediatric clinics (SAFE-Rx for Kids study). English/Spanish-speaking parents (n=493) of children <8 years were randomized to 1 of 4 study arms and given labels/dosing tools which varied in label instruction format (text+pictogram, text-only) and units (mL-only, mL/tsp)...
April 8, 2017: Academic Pediatrics
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