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https://www.readbyqxmd.com/read/29240547/implementing-cdc-s-level-of-care-assessment-tool-locate-a-national-collaboration-to-improve-maternal-and-child-health
#1
Andrea Catalano, Amanda Bennett, Ashley Busacker, Alethia Carr, David Goodman, Charlan Kroelinger, Ekwutosi Okoroh, Mary Brantley, Wanda Barfield
Perinatal regionalization, or risk-appropriate care, is an approach that classifies facilities based on capabilities to ensure women and infants receive care at a facility that aligns with their risk. The CDC designed the Levels of Care Assessment Tool (LOCATe) to assist jurisdictions working in risk-appropriate care in assessing a facility's level of maternal and neonatal care aligned with the most current American College of Obstetricians and Gynecologists/Society for Maternal-Fetal Medicine (ACOG/SMFM) and American Academy of Pediatrics (AAP) guidelines...
December 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29235404/understanding-the-interactions-of-different-substrates-with-wild-type-and-mutant-acylaminoacyl-peptidase-using-molecular-dynamics-simulations
#2
Jingxuan Zhu, Yan Wang, Xin Li, Weiwei Han, Li Zhao
Acylaminoacylpeptidase (AAP) belongs to peptidase protein family (POP), which can degrade amyloid β-peptide forms in the brains of patients and hence leads to Alzheimer's disease. And so, AAP is considered to be a novel target in the design of drugs against Alzheimer's disease. In this investigation, six molecular dynamics simulations were used to find that the interaction between the wild-type and R526V AAP with two different substrates (p-nitrophenylcaprylate and Ac-Leu-p-nitroanilide). Our results were as follows: firstly, Ac-Leu-p-nitroanilide bound to R526V AAP to form a more disordered loop (residues 552-562) in the α/β-hydrolase fold like of AAP, which caused an open and inactive AAP domain form, secondly, binding p-nitrophenylcaprylate and Ac-Leu-p-nitroanilide to AAP can decrease the flexibility of residues 225-250, 260-270 and 425-450, in which the ordered secondary structures may contain the suitable geometrical structure and so it is useful to serine attack...
December 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29223665/guidelines-and-checklists-for-short-term-missions-in-global-pediatric-surgery-recommendations-from-the-american-academy-of-pediatrics-delivery-of-surgical-care-global-health-subcommittee-american-pediatric-surgical-association-global-pediatric-surgery-committee
#3
REVIEW
Marilyn Butler, Elizabeth Drum, Faye M Evans, Tamara Fitzgerald, Jason Fraser, Ai-Xuan Holterman, Howard Jen, J Matthew Kynes, Jenny Kreiss, Craig D McClain, Mark Newton, Benedict Nwomeh, James O'Neill, Doruk Ozgediz, George Politis, Henry Rice, David Rothstein, Julie Sanchez, Mark Singleton, Francine S Yudkowitz
INTRODUCTION: Pediatric surgeons, anesthesia providers, and nurses from North America and other high-income countries (HICs) are increasingly engaged in resource-limited areas, with short-term missions (STMs) as the most common form of involvement. However, consensus recommendations currently do not exist for STMs in pediatric general surgery and associated perioperative care. METHODS: The American Academy of Pediatrics (AAP) Delivery of Surgical Care Subcommittee and American Pediatric Surgical Association (APSA) Global Pediatric Surgery Committee, with the American Pediatric Surgical Nurses Association, Inc...
November 15, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29221528/evaluation-of-iron-deficiency-anemia-in-a-pediatric-clinic-in-the-dominican-republic
#4
Steven G McKee, Ryan Close, Elizabeth Lowenthal
BACKGROUND: Iron deficiency and iron deficiency anemia affect billions of people worldwide. Infants and young children are the most vulnerable. The Niños Primeros en Salud pediatric clinic aims to follow the American Academy of Pediatrics (AAP) recommendation to screen all children at 12 months of age, a vital period for development and the time of greatest risk. OBJECTIVES: To evaluate the clinic's performance screening for, diagnosing, and treating iron deficiency anemia; and to describe the prevalence and severity of anemia in infants and children attending a perirural clinic in the Dominican Republic...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29215363/nano-tio2-ultrasound-and-sequential-nano-tio2-ultrasonic-degradation-of-n-acetyl-para-aminophenol-from-aqueous-solution
#5
Olushola S Ayanda, Simphiwe M Nelana, Leslie F Petrik, Eliazer B Naidoo
The application of nano-TiO2 as adsorbent combined with ultrasound for the degradation of N-acetyl-para-aminophenol (AAP) from aqueous solution was investigated. The nano-TiO2 was characterized by means of powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), and attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR). Experimental results revealed that the adsorption of AAP by nano-TiO2 fitted the pseudo-second-order kinetic model, the equilibrium could be explained by the Freundlich isotherm and the treatment process is exothermic...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29212457/the-decision-delivery-interval-in-emergency-caesarean-section-and-its-associated-maternal-and-fetal-outcomes-at-a-referral-hospital-in-northern-tanzania-a-cross-sectional-study
#6
Birjna A Hirani, Bariki L Mchome, Nicholaus S Mazuguni, Michael J Mahande
BACKGROUND: Decision delivery interval (DDI) is the time line between a decision to conduct an emergency caesarean section and actual delivery of the baby. Prolong DDI constitute a third phase delay in provision of emergency obstetric care. Intervention designed to minimize DDI are vital, in attempt to prevent maternal morbidity and neonatal morbidity and mortality. The feasibility and practicability of the recommended DDI in recent studies have been questioned especially in limited resource setting and therefore the objective of our study was to determine the DDI and its associated fetalmaternal outcomes at a tertiary referral hospital in Tanzania...
December 7, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29209032/comparison-of-state-risk-appropriate-neonatal-care-policies-with-the-2012-aap-policy-statement
#7
Charlan D Kroelinger, Ekwutosi M Okoroh, David A Goodman, Sarah M Lasswell, Wanda D Barfield
OBJECTIVE: Compare state policies with standards outlined in the 2012 AAP Policy Statement on Levels of Neonatal Care. STUDY DESIGN: Systematic, web-based review of publicly available policies on levels of care in all states in 2014. Infant risk information, equipment capabilities, and specialty staffing were abstracted from published rules, statutes, and regulations. RESULT: Twenty-two states had a policy on regionalized perinatal care. State policies vary in consistency with the AAP Policy, with 60% of states including standards consistent with Level I criteria, 48% Level II, 14% Level III, and one state with Level IV...
December 5, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29208508/scientific-evidence-on-the-links-between-periodontal-diseases-and-diabetes-consensus-report-and-guidelines-of-the-joint-workshop-on-periodontal-diseases-and-by-the-international-diabetes-federation-and-the-european-federation-of-periodontology
#8
Mariano Sanz, Antonio Ceriello, Martin Buysschaert, Iain Chapple, Ryan T Demmer, Filippo Graziani, David Herrera, Søren Jepsen, Luca Lione, Phoebus Madianos, Manu Mathur, Eduard Montanya, Lior Shapira, Maurizio Tonetti, Daniel Vegh
BACKGROUND: Diabetes and periodontitis are chronic non-communicable diseases independently associated with mortality and have a bidirectional relationship. AIMS: To update the evidence for their epidemiological and mechanistic associations and re-examine the impact of effective periodontal therapy upon metabolic control (glycated haemoglobin, HbA1C). EPIDEMIOLOGY: There is strong evidence that people with periodontitis have elevated risk for dysglycaemia and insulin resistance...
December 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29198616/incidence-of-hypoglycemia-in-newborns-at-risk-and-an-audit-of-the-2011-american-academy-of-pediatrics-guideline-for-hypoglycemia
#9
Nihan Hilal Hosagasi, Mustafa Aydin, Aysegul Zenciroglu, Nuran Ustun, Serdar Beken
BACKGROUND: Hypoglycemia is low blood glucose level that may negatively affect neurological and developmental prognosis. The American Academy of Pediatrics (AAP), Committee on Fetus and Newborn defined the safe glucose concentrations in the 2011 guideline for newborns at risk for hypoglycemia. This study aimed to investigate the incidence and associated risk factors for hypoglycemia in newborn infants having risk and to assess compliance with the AAP guideline. METHODS: According to 2011 AAP guideline for hypoglycemia, the newborns at risk for hypoglycemia included in this study were divided to four groups [infant of diabetic mother (IDM), large-for-gestational-age (LGA) infants, small-for-gestational-age (SGA) infants, and late preterm infants (LPI)]...
November 15, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29196830/a-multi-site-in-depth-evaluation-of-the-quanterix-simoa-from-a-user-s-perspective
#10
Allison Given Chunyk, Alison Joyce, Saloumeh K Fischer, Mark Dysinger, Alvydas Mikulskis, Andreas Jeromin, Rosemary Lawrence-Henderson, Dana Baker, David Yeung
An in-depth evaluation of the Quanterix© Simoa™ platform was undertaken by scientists from the AAPS Emerging Technologies Focus Group to determine the overall performance of the technology as well as provide guidance to future users. In order to test the platform in a non-GLP bioanalytical setting, a cross-site evaluation of the Quanterix IL-6 biomarker kit was performed. Parameters tested during this evaluation included sensitivity, accuracy and precision, and parallelism in human serum from normal individuals...
December 1, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29184815/transient-hypothyroidism-in-the-newborn-to-treat-or-not-to-treat
#11
REVIEW
Neelakanta Kanike, Ajuah Davis, Prem S Shekhawat
Transient congenital hypothyroidism (CH) refers to a temporary deficiency of thyroid hormone identified after birth, with low thyroxine (T4) and elevated thyrotropin (TSH), which later recovers to improved thyroxine production, typically in first few months of infancy. Approximately 17% to 40% of children diagnosed with CH by newborn screening (NBS) programs were later determined to have transient hypothyroidism. Causes of transient CH are prematurity, iodine deficiency, maternal thyrotropin receptor blocking antibodies, maternal intake of anti-thyroid drugs, maternal or neonatal iodine exposure, loss of function mutations and hepatic hemangiomas...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29176102/quality-health-care-for-homeless-children-achieving-the-aap-recommendations-for-care-of-homeless-children-and-youth
#12
Avik Chatterjee, Marvin So, Spencer Dunleavy, Emily Oken
BACKGROUND: We assessed whether and how health care organizations serving homeless pediatric patients meet recommendations issued by the American Academy of Pediatrics (AAP). METHODS: We conducted a web-based survey of Health Care for the Homeless (HCH) Program grantees serving children. RESULTS: Of 169 grantees, 77 (46%) responded. All organizations reported connecting patients to specialty services. Nearly all reported screening for homelessness (90%), facilitating Medicaid enrollment (90%), connecting patients to benefits (94%), addressing underlying causes of homelessness (83%), assisting with transportation (83%), and knowing about the causes of homelessness (76%)...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/29163731/acute-abdominal-pain-assessment-in-the-emergency-department-the-experience-of-a-greek-university-hospital
#13
Dimitrios Velissaris, Menelaos Karanikolas, Nikolaos Pantzaris, George Kipourgos, Vasileios Bampalis, Konstantina Karanikola, Eleftheria Fafliora, Christina Apostolopoulou, Charalampos Gogos
Background: Acute abdominal pain (AAP) is a common symptom in the emergency department (ED). Because abdominal pain can be caused by a wide spectrum of underlying pathology, evaluation of abdominal pain in the ED requires a comprehensive approach, based on patient history, physical examination, laboratory tests and imaging studies. The aim of this study was to investigate predictive factors for admission to the hospital in patients who presented to the ED with AAP as the main symptom...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29161896/qualitative-analysis-of-infant-safe-sleep-public-campaign-messaging
#14
Nadine R Peacock, Susan Altfeld, Allison L Rosenthal, Caitlin E Garland, Jill M Massino, Sherri L Smith, Hillary L Rowe, Sarah E Wagener
The 1994 Back to Sleep public education campaign resulted in dramatic reductions in sleep-related infant deaths, but comparable progress in recent years has been elusive. We conducted qualitative analyses of recent safe sleep campaigns from 13 U.S. cities. Goals were to (a) determine whether the campaigns reflect the full range of American Academy of Pediatrics (AAP) 2011 safe sleep recommendations, (b) describe tone and framing of the messages (e.g., use of fear appeals), (c) describe targeting/tailoring of messages to priority populations, and (d) ascertain whether the campaigns have been evaluated for reach and/or effectiveness...
March 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/29159858/non-linear-effect-of-irradiance-on-photoheterotrophic-activity-and-growth-of-the-aerobic-anoxygenic-phototrophic-bacterium-dinoroseobacter-shibae
#15
Kasia Piwosz, David Kaftan, Jason Dean, Jiří Šetlík, Michal Koblížek
Aerobic Anoxygenic Photosynthetic (AAP) bacteria are an important component of marine microbial communities. They produce energy in light using bacteriochlorophyll a containing photosystems. This extra energy provides an advantage over purely heterotrophic bacteria. One of the most intensively studied AAP bacteria is Dinoroseobacter shibae, a member of the environmentally important Roseobacter clade. Light stimulates its growth and metabolism, but the effect of light intensity remains unclear. Here, we show that an increase in biomass along an irradiance gradient followed the exponential rise to the maximum curve, with saturation at about 300 µmol photons m(-2) s(-1) , without any inhibition at light intensities up to 600 µmol photons m(-2) s(-1) ...
November 21, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29156255/competitive-adsorption-of-ppcp-and-humic-substances-by-carbon-nanotube-membranes-effects-of-coagulation-and-ppcp-properties
#16
Yifei Wang, Qing Yang, Junqing Dong, Haiou Huang
Natural organic matter (NOM) and pharmaceuticals and personal care products (PPCP) are known to compete for adsorption sites on carbon nanotubes (CNT), resulting in decreasing PPCP adsorption onto CNT. In this study, four types of PPCP, as such acetaminophen (AAP), caffeine (CAF), triclosan (TCS), and carbendazim (CBD) were used to investigate the effects of PPCP properties and NOM coagulation on the competitive adsorption of PPCP and NOM. Coagulation preferentially removed HS from a natural surface water, thereby increasing adsorption of AAP, CAF, TCS and CBD by 19%, 13%, 17% and 11%, respectively...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149994/a-novel-fluorescence-biosensor-for-sensitivity-detection-of-tyrosinase-and-acid-phosphatase-based-on-nitrogen-doped-graphene-quantum-dots
#17
Zhengyi Qu, Weidan Na, Xiaotong Liu, Hua Liu, Xingguang Su
In this paper, we developed a sensitive fluorescence biosensor for tyrosinase (TYR) and acid phosphatase (ACP) activity detection based on nitrogen-doped graphene quantum dots (N-GQDs). Tyrosine could be catalyzed by TYR to generate dopaquinone, which could efficiently quench the fluorescence of N-GQDs, and the degree of fluorescence quenching of N-GQDs was proportional to the concentration of TYR. In the presence of ACP, l-Ascorbic acid-2-phosphate (AAP) was hydrolyzed to generate ascorbic acid (AA), and dopaquinone was reduced to l-dopa, resulting in the fluorescence recovery of the quenched fluorescence by dopaquinone...
January 2, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29143501/-the-place-of-balloon-pulmonary-angioplasty-in-the-management-of-chronic-thromboembolic-pulmonary-hypertension
#18
Aileen Kharat, Béatrice Duxbury, Anne-Lise Hachull, Stéphane Noble, Hélène Bouvaist, Paola M Soccal, Frédéric Lador
Chronic thromboembolic pulmonary hypertension (CTEPH) is uncommon. Its diagnosis should not be delayed as its prognosis is poor if not treated. In most cases, an acute pulmonary embolism is found in the medical history of the patient. Once suspected, a specific work-up should be performed in a pulmonary hypertension (PH) center. The ventilation/perfusion scan has a central role in this workup but the emergence of non invasive imaging technologies provides morphological and functional information which take part in the therapeutic decision making, such as operability...
November 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29132812/the-antitumor-effect-of-folic-acid-conjugated-auricularia-auricular-polysaccharide-cisplatin-complex-on-cervical-carcinoma-cells-in-nude-mice
#19
Junqiang Qiu, Hua Zhang, Zhenyu Wang, Didi Liu, Shumin Liu, Wei Han, Joe M Regenstein, Lin Geng
A tumor-targeted, folic acid (FA) conjugated-Auricularia auricular polysaccharide (AAP) -cis-diaminedichloroplatinum (CDDP) complex (FA-AAP-CDDP) was used for cervical carcinoma chemotherapy. The drug delivery system was able to enhance the antitumor potency of CDDP, and to reduce the toxic side effects of CDDP. The kidney of mice treated by FA-AAP-CDDP complex had higher superoxide dismutase, catalase, and glutathione peroxidase activities, and lower malondialdehyde. FA-AAP-CDDP complex could induce more interleukin-2, interleukin-4, and interferon-γ in mice...
November 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29129740/survey-on-neonatal-end-of-life-comfort-care-guidelines-across-america
#20
Shelly Haug, Sara Farooqi, Christopher G Wilson, Andrew Hopper, Grace Oei, Brian Carter
CONTEXT: Infants of age < 1 year have the highest mortality rate in pediatrics. The American Academy of Pediatrics (AAP) published guidelines for palliative care in 2013, however, significant variation persists among local protocols addressing neonatal comfort care at the end-of-life (EOL). OBJECTIVES: The purpose of this study was to evaluate current neonatal EOL comfort care practices and clinician satisfaction across America METHODS: After Institutional Review Board approval (516005), an anonymous, electronic survey was sent to members of the AAP Section on Neonatal-Perinatal Medicine...
November 9, 2017: Journal of Pain and Symptom Management
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