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https://www.readbyqxmd.com/read/28810972/when-military-fitness-standards-no-longer-apply-the-high-prevalence-of-metabolic-syndrome-in-recent-air-force-retirees
#1
Marcus M Cranston, Mark W True, Jana L Wardian, Rishawn M Carriere, Tom J Sauerwein
BACKGROUND: Metabolic syndrome (MetS) is strongly associated with cardiovascular disease. With MetS prevalence rates increasing in the U.S. population, prevention efforts have largely focused on diet and exercise interventions. Before retirement, military service members have met fitness requirements for at least 20 years, and have lower MetS rates compared to age-matched U.S. population controls (23.4% vs. 39.0%), which suggests a protective effect of the lifestyle associated with military service...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808933/cardiovascular-disease-in-clozapine-treated-patients-evidence-mechanisms-and-management
#2
REVIEW
Kathlyn J Ronaldson
Myocarditis occurs in about 3% of those initiated on clozapine but monitoring reduces the risk of serious outcome. Cardiomyopathy may develop after myocarditis, or from prolonged tachycardia. Monitoring using echocardiography is not deemed cost effective. Tachycardia, orthostatic hypotension and reduced heart rate variability are a group of clozapine-related adverse effects associated with autonomic dysfunction and may have serious consequences in the long term. Elevated heart rate and poor heart rate variability can be treated with a β-blocker or a non-dihydropyridine calcium channel blocker, while orthostatic hypotension can be alleviated by increased fluid intake and abdominal binding, but may require pharmacological intervention...
August 14, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28801940/examining-the-association-between-depression-and-obesity-during-a-weight-management-programme
#3
N R Fuller, J Burns, A Sainsbury, S Horsfield, F da Luz, S Zhang, G Denyer, T P Markovic, I D Caterson
The prevalence of depression in those with obesity is reported to be as high as double that in individuals of normal weight. There is potentially a bi-directional relationship between obesity and depression. Some research has suggested that depression results in weight gain and obesity, and other studies have suggested that those with obesity are more likely to develop depression at a later stage. The aim of this study was to investigate the association of depression symptoms with weight change over a 12-month study...
August 11, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28797298/community-characteristics-of-the-gut-microbiomes-of-competitive-cyclists
#4
Lauren M Petersen, Eddy J Bautista, Hoan Nguyen, Blake M Hanson, Lei Chen, Sai H Lek, Erica Sodergren, George M Weinstock
BACKGROUND: Changes in diet and exercise can alter the gut microbiome of humans and mice; however, few studies to date have assessed the microbiomes of highly fit athletes. In this pilot study, we used metagenomic whole genome shotgun (mWGS) and metatranscriptomic (RNA-Seq) sequencing to show what organisms are both present and active in the gut microbiomes of both professional and amateur level competitive cyclists and to determine if any significant differences exist between these two groups...
August 10, 2017: Microbiome
https://www.readbyqxmd.com/read/28794802/healthy-lifestyle-intervention-for-adult-clinic-patients-with-type-2-diabetes-mellitus
#5
Steven S Coughlin, Christos Hatzigeorgiou, Judith Anglin, Ding Xie, Gina M Besenyi, Gianluca De Leo, Jessica Stewart, Thad Wilkins
BACKGROUND: Diet and exercise therapy have been reported to be effective in improving blood glucose control and are an important part of treatment of type 2 diabetes mellitus. OBJECTIVE: The goal of this study is to examine the efficacy of a healthy lifestyle intervention for adult clinic patients with type 2 diabetes mellitus, as measured by Hgb-A1c, cardiovascular indicators, physical activity, weight, and BMI. Also of interest are optimal strategies for subject recruitment, the number of intervention sessions attended, and participant use of the Fitbit watch to monitor their physical activity and track food and beverage consumption...
2017: Diabetes Management
https://www.readbyqxmd.com/read/28792330/healthy-eating-and-exercise-lessen-chance-of-c-section
#6
(no author information available yet)
Diet and lifestyle advice for pregnant women could reduce the odds of needing a caesarean section, a new analysis has suggested.
August 9, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28789631/efficacy-of-glutathione-for-the-treatment-of-nonalcoholic-fatty-liver-disease-an-open-label-single-arm-multicenter-pilot-study
#7
Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, Atsushi Nakajima
BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28779908/differential-effects-of-voluntary-treadmill-exercise-and-caloric-restriction-on-tau-pathogenesis-in-a-mouse-model-of-alzheimer-s-disease-like-tau-pathology-fed-with-western-diet
#8
Maud Gratuze, Jacinthe Julien, Françoise Morin, André Marette, Emmanuel Planel
BACKGROUND: Tau is a microtubule-associated protein that becomes pathological when it undergoes hyperphosphorylation and aggregation as seen in Alzheimer's disease (AD). AD is mostly sporadic, with environmental, biological and/or genetic risks factors, interacting together to promote the disease. In the past decade, reports have suggested that obesity in midlife could be one of these risk factors. On the other hand, caloric restriction and physical exercise have been reported to reduce the incidence and outcome of obesity as well as AD...
August 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28777749/baseline-telomere-length-and-effects-of-a%C3%A2-multidomain-lifestyle-intervention-on-cognition-the-finger-randomized-controlled-trial
#9
Shireen Sindi, Tiia Ngandu, Iiris Hovatta, Ingemar Kåreholt, Riitta Antikainen, Tuomo Hänninen, Esko Levälahti, Tiina Laatikainen, Jaana Lindström, Teemu Paajanen, Markku Peltonen, Dharma Singh Khalsa, Benjamin Wolozin, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto, Alina Solomon
Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60-77 years identified from the general population...
July 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28771283/medication-assisted-weight-loss-in-the-age-of-obesity
#10
Laura G Leahy
Obesity is a complex and potentially deadly health concern; yet, there are few medications available to treat this chronic, recurrent disease. Patients are frequently told to "lose weight" and change their diet and exercise habits. For many, making behavioral lifestyle changes is not enough to enhance weight loss efforts and improve overall health and quality of life. Medication-assisted weight loss must be considered as an adjunct treatment to lifestyle changes, as neither alone may provide the sustainable reduction in weight necessary to decrease the medical and psychiatric comorbidities associated with obesity...
August 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28762507/increasing-physical-activity-for-veterans-in-the-mental-health-intensive-case-management-program-a-community-based-intervention
#11
S Akeya Harrold, Julian Libet, Charlene Pope, Joy A Lauerer, Emily Johnson, Barbara J Edlund
AIMS AND OBJECTIVES: Individuals with severe mental illness (SMI), experience increased mortality-20 years greater disparity for men and 15 years greater disparity for women-compared to the general population (Thornicroft G. Physical health disparities and mental illness: The scandal of premature mortality. Br J Psychiatr. 2011;199:441-442). Numerous factors contribute to premature mortality in persons with SMI, including suicide and accidental death (Richardson RC, Faulkner G, McDevitt J, Skrinar GS, Hutchinson D, Piette JD...
August 1, 2017: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/28761689/efficacy-of-dietary-and-physical-activity-intervention-in-non-alcoholic-fatty-liver-disease-a-systematic-review
#12
Susan Kenneally, Joanna H Sier, J Bernadette Moore
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, with prevalence above 30% in many adult populations. Strongly associated with obesity, weight loss through diet and physical activity is the mainstay of its management. Weight loss can be difficult to achieve and maintain however, and uncertainty exists as to which lifestyle changes are most effective. OBJECTIVE: The aim of this work was to systematically evaluate randomised controlled trials assessing diet, exercise or combination interventions aimed at reducing steatosis or markers of NAFLD activity...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28761649/discovering-successful-strategies-for-diabetic-self-management-a-qualitative-comparative-study
#13
Susan C Weller, Roberta Baer, Anita Nash, Noe Perez
OBJECTIVE: This project explored lifestyles of patients in good and poor control to identify naturally occurring practices and strategies that result in successful diabetes management. RESEARCH DESIGN AND METHODS: Semistructured interviews with adult patients with type 2 diabetes explored diet, food preparation, physical activity, medication use and glucose monitoring. Patients (n=56) were classified into good (A1C <7.0%), fair (7.0%<A1C<8.0%) or poor (A1C >8...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28760220/weight-and-type-2-diabetes-new-recommendations
#14
Ricardo Gómez Huelgas
Most patients with type 2 diabetes have excess adiposity. There is wide consensus that adequate treatment of type 2 diabetes requires a simultaneous approach to overweight/obesity and the remaining cardiovascular risk factors. Non-pharmacological interventions (diet, exercise) represent the cornerstone of the treatment of patients with type 2 diabetes. Weight loss through lifestyle modification has shown clear benefits in these patients, requiring an individualised and multidisciplinary approach with structured programmes endowed with specific resources...
November 2016: Medicina Clínica
https://www.readbyqxmd.com/read/28755177/evidence-base-for-multidisciplinary-care-of-pediatric-adolescent-bariatric-surgery-patients
#15
REVIEW
Mohamed O Elahmedi, Aayed R Alqahtani
PURPOSE OF REVIEW: Severe childhood obesity, defined as having a body mass index (BMI) greater than the 99th percentile for age and gender, is rising in most countries and is associated with early morbidity and mortality. Optimal management of the health of the child with obesity requires a multidisciplinary approach that identifies and treats associated derangements. RECENT FINDINGS: Lifestyle interventions such as diet, exercise, and behavioral therapy for the severely obese pediatric patient are generally not effective...
July 28, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28748625/multiple-risk-factor-counseling-to-promote-heart-healthy-lifestyles-in-the-chest-pain-observation-unit-pilot-randomized-controlled-trial
#16
David A Katz, Mark Graber, Patricia Lounsbury, Mark W Vander Weg, Emily K Phillips, Christina Clair, Phillip A Horwitz, Xueya Cai, Alan J Christensen
OBJECTIVE: Admission to the chest pain observation unit (CPOU) may be an advantageous time for patients to consider heart-healthy lifestyle changes while undergoing diagnostic evaluation to rule out myocardial ischemia. The aim of this pragmatic trial was to assess the effectiveness of a multiple risk factor intervention in changing CPOU patients' health beliefs and readiness to change health behaviors. A secondary aim was to obtain preliminary estimates of the intervention's effect on diet, physical activity, and smoking...
July 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28739540/the-women-in-steady-exercise-research-wiser-survivor-trial-the-innovative-transdisciplinary-design-of-a-randomized-controlled-trial-of-exercise-and-weight-loss-interventions-among-breast-cancer-survivors-with-lymphedema
#17
Renate M Winkels, Kathleen M Sturgeon, Michael J Kallan, Lorraine T Dean, Zi Zhang, Margaret Evangelisti, Justin C Brown, David B Sarwer, Andrea B Troxel, Crystal Denlinger, Monica Laudermilk, Anna Fornash, Angela DeMichele, Lewis A Chodosh, Kathryn H Schmitz
INTRODUCTION: Breast cancer survivors face dual challenges: long term sequelae of treatment, and risk of recurrent disease. Obesity and a sedentary lifestyle complicate both challenges. The WISER Survivor trial assessed the effects of exercise and/or weight-loss on lymphedema, biomarkers of breast cancer recurrence, and quality of life. We report on the innovative transdisciplinary design of this trial and report attrition rates. METHODS: This one year trial randomized breast cancer survivors who had a BMI of ≥25kg/m(2), were sedentary and had breast-cancer-related-lymphedema to 1) exercise (weight training and aerobic exercise) 2) weight-loss 3) exercise and weight-loss 4) or control group...
July 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28729620/self-management-behaviour-and-support-among-primary-care-copd-patients-cross-sectional-analysis-of-data-from-the-birmingham-chronic-obstructive-pulmonary-disease-cohort
#18
Ainee Khan, Andrew P Dickens, Peymane Adab, Rachel E Jordan
Self-management support for chronic obstructive pulmonary disease (COPD) patients is recommended by UK national guidelines, but extent of implementation is unknown. We aimed to describe self-management behaviour and support among COPD patients and explore behaviour associated with having a self-management plan. We undertook cross-sectional analysis of self-reported data from diagnosed COPD patients in the Birmingham COPD Cohort study. Questionnaire items relevant to self-management behaviour, knowledge of COPD, receipt of self-management plans and advice from healthcare professionals were examined...
July 20, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28727165/increased-fibre-and-reduced-trans-fatty-acid-intake-are-primary-predictors-of-metabolic-improvement-in-overweight-polycystic-ovary-syndrome-substudy-of-randomized-trial-between-diet-exercise-and-diet-plus-exercise-for-weight-control
#19
Åsa Nybacka, Per M Hellström, Angelica L Hirschberg
OBJECTIVE: Polycystic ovary syndrome (PCOS) is commonly affected by obesity. PCOS phenotypes are prone to increased waist/hip ratio, insulin resistance and dyslipidaemia. This substudy was undertaken to evaluate the effects of lifestyle interventions on metabolic biomarkers in overweight/obese PCOS women, and the interventional effects of dietary components related to metabolic outcomes. DESIGN: Randomized three-arm parallel study. PATIENTS: Fifty-seven PCOS women (BMI >27kg/m(2) , age 18-40) were randomly assigned to diet (D, n=19), exercise (E, n=19) or diet plus exercise (DE, n=19) in three-arm fashion over 16 weeks...
July 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28725153/ovulation-induction-by-metformin-among-obese-versus-non-obese-women-with-polycystic-ovary-syndrome
#20
Yazed Sulaiman Al-Ruthia, Hazem Al-Mandeel, Hisham AlSanawi, Wael Mansy, Reem AlGasem, Lama AlMutairi
OBJECTIVES: There is some evidence that the efficacy of metformin as an ovulation stimulation agent depends on the body mass index (BMI) of the treated anovulatory women with polycystic ovary syndrome (PCOS). The aim of this study was to examine the likelihood of successful ovulation among obese (BMI ⩾30 kg/m(2)) versus non-obese (BMI <30 kg/m(2)) women with PCOS. METHODS: A total of 243 medical charts of women with PCOS who visited King Khaled University Hospital (KKUH) in Riyadh, Saudi Arabia, between 2006 and 2012 were reviewed...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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