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https://www.readbyqxmd.com/read/28640632/gut-microbiota-nitric-oxide-and-microglia-as-pre-requisites-for-neurodegenerative-disorders
#1
Joyce Ka Yu Tse
Regulating fluctuating endogenous nitric oxide (NO) levels is necessary for proper physiological functions. Aberrant NO pathways are implicated in a number of neurological disorders, including Alzheimer's Disease (AD) and Parkinson's Disease. The mechanism of NO in oxidative and nitrosative stress with pathological consequences involves reactions with reactive oxygen species (e.g. superoxide) to form the highly reactive peroxynitrite, hydrogen peroxide, hypochloride ions and hydroxyl radical. NO levels are typically regulated by endogenous nitric oxide synthases (NOS), and inflammatory iNOS is implicated in the pathogenesis of neurodegenerative diseases, in which elevated NO mediates axonal degeneration and activates cyclooxygenases to provoke neuroinflammation...
June 22, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28637073/-complementary-and-alternative-medicine-in-oncology-what%C3%A2-makes-sense
#2
Axel Eustachi, Dieter Melchart
The basis of any complementary therapy should be the recommendation of a healthy lifestyle (diet, nutrition, exercise, stress-reduction), and appropriate self-help techniques (e. g. thermotherapy, herbal OTC-products) aimed at releasing the patients' most debilitating symptoms. For therapy-resistant or strong symptoms, more invasive interventions or medical treatments with an acceptable evidence base can be used (e. g. acupuncture for cancer pain, herbal prescriptions). The effects of any complementary intervention should be controlled for a period of six weeks after its administration...
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28636519/how-we-eat-may-be-as-important-as-what-we-eat-eating-behaviour-and-heart-rate-variability
#3
Mehmet Emre Ozpelit, Ebru Ozpelit
Objective Diet exerts a crucial role on cardiovascular health. Evidence is mainly based on the content and the amount of dietary intakes. Some recent reports demonstrated that eating behaviour may also be of significant importance in cardiovascular health. In this study we aimed to investigate the effects of eating behaviour on heart rate variability (HRV) in healthy subjects. Methods and results In total, 521 healthy subjects with 24-hour Holter ECG recordings filled out a special questionnaire about their eating behaviour and lifestyles...
March 30, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28632180/preview-prevention-of-diabetes-through-lifestyle-intervention-and-population-studies-in-europe-and-around-the-world-design-methods-and-baseline-participant-description-of-an-adult-cohort-enrolled-into-a-three-year-randomised-clinical-trial
#4
Mikael Fogelholm, Thomas Meinert Larsen, Margriet Westerterp-Plantenga, Ian Macdonald, J Alfredo Martinez, Nadka Boyadjieva, Sally Poppitt, Wolfgang Schlicht, Gareth Stratton, Jouko Sundvall, Tony Lam, Elli Jalo, Pia Christensen, Mathijs Drummen, Elizabeth Simpson, Santiago Navas-Carretero, Teodora Handjieva-Darlenska, Roslyn Muirhead, Marta P Silvestre, Daniela Kahlert, Laura Pastor-Sanz, Jennie Brand-Miller, Anne Raben
Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated...
June 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28631241/improving-self-management-of-type-2-diabetes-in-overweight-and-inactive-patients-through-an-educational-and-motivational-intervention-addressing-diet-and-physical-activity-a-prospective-study-in-naples-south-italy
#5
Francesca Gallé, Valeria Di Onofrio, Assunta Cirella, Mirella Di Dio, Alessandra Miele, Tiziana Spinosa, Giorgio Liguori
INTRODUCTION: Nutrition and physical activity are key elements in the prevention and management of type 2 diabetes. A community-based, multidisciplinary educational intervention aimed to improve quality of life and disease self-management in sedentary, overweight/obese type 2 diabetic patients was implemented in Naples, South Italy. METHODS: The 9-month intervention included a motivational program, a nutrition program, and an exercise program. Satisfaction, worry, and embarrassment regarding their condition, together with disease-related behaviors and propensity towards physical activity, were evaluated through a validated questionnaire before and after the intervention; health status perception was evaluated through the short-form 12 questionnaire...
June 19, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28628597/integrating-health-promotion-into-physical-therapy-practice-to-improve-brain-health-and-prevent-alzheimer-disease
#6
Ellen McGough, Neva Kirk-Sanchez, Teresa Liu-Ambrose
BACKGROUND AND PURPOSE: Alzheimer disease is the most common cause of dementia, and brain pathology appears years before symptoms are evident. Primary prevention through health promotion can incorporate lifestyle improvement across the lifespan. Risk factor assessment and identifying markers of disease might also trigger preventive measures needed for high-risk individuals and groups. SUMMARY OF KEY POINTS: Many potential risk factors are modifiable through exercise, and may be responsive to early intervention strategies to reduce the downward slope toward disability...
July 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28628596/from-disease-to-health-physical-therapy-health-promotion-practices-for-secondary-prevention-in-adult-and-pediatric-neurologic-populations
#7
Lori Quinn, Don Morgan
BACKGROUND AND PURPOSE: Over the last decade there has been a substantial increase in efforts to better understand how targeted physical activity and exercise interventions can be used to minimize secondary consequences arising from neurological damage in both adult and pediatric populations. This article offers an overview of contemporary research that addresses mediators of functional and neuroplastic adaptations associated with physical activity and exercise. We emphasize the important role that physical therapists can play to increase participation and improve well-being in adults and children with neurological disorders...
July 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28628590/the-past-present-and-future-of-neurorehabilitation-from-nustep-through-iv-step-and-beyond
#8
Susan R Harris, Carolee J Winstein
PURPOSES: To present the history and aims of the STEP conferences; describe the interdependence of prevention, prediction, plasticity, and participation; reflect on where we stand today regarding those 4 Ps; and discuss how future neurorehabilitation should look for individuals with movement disorders. KEY POINTS: Physical therapists have focused primarily on tertiary prevention, emphasizing primary/secondary prevention far less. Predicting optimal response to intervention is essential for primary prevention...
July 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28627254/randomized-trial-of-a-lifestyle-physical-activity-intervention-for-breast-cancer-survivors-effects-on-transtheoretical-model-variables
#9
Stacie Scruggs, Scherezade K Mama, Cindy L Carmack, Tommy Douglas, Pamela Diamond, Karen Basen-Engquist
This study examined whether a physical activity intervention affects transtheoretical model (TTM) variables that facilitate exercise adoption in breast cancer survivors. Sixty sedentary breast cancer survivors were randomized to a 6-month lifestyle physical activity intervention or standard care. TTM variables that have been shown to facilitate exercise adoption and progress through the stages of change, including self-efficacy, decisional balance, and processes of change, were measured at baseline, 3 months, and 6 months...
June 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28626106/-seedi-basic-strategies-for-the-primary-and-secondary-prevention-of-atherosclerotic-cardiovascular-disease
#10
Chunsong Hu
ABCDE strategy, mainly based on drugs or medications and the lifestyle modification (named as "main medical strategy"), is popular in the guideline for primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) in China and foreign countries. Here, the author recommends a non-invasive and non-pharmacologic "Zhongzi" rule, which includes 4 healthy elements: Sleep, emotion, exercise, and diet (SEED), and also called SEED intervention (SEEDi) strategy. It is the basic strategy for primary and secondary prevention of non-infectious diseases, especially for ASCVD...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28625704/mental-health-consequences-of-exercise-withdrawal-a-systematic-review
#11
REVIEW
Ali A Weinstein, Christine Koehmstedt, Willem J Kop
OBJECTIVE: A sedentary lifestyle has been associated with mental health disorders. Many medical conditions result in the cessation of exercise, which may increase the risk of developing mental health problems. The purpose of this article is to systematically review the literature examining the effects of exercise withdrawal on mental health. METHOD: Literature was searched using PubMed, PsycINFO, and SPORTdiscus for studies that experimentally manipulated the withdrawal of exercise and included mental health as outcome measure...
June 6, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28625282/high-intensity-exercise-training-for-improving-reproductive-function-in-infertile-patients-a-randomized-controlled-trial
#12
Behzad Hajizadeh Maleki, Bakhtyar Tartibian
OBJECTIVE: The purpose of this RCT was to investigate whether a 24-week program of high-intensity exercise was beneficial for improving reproductive function in infertile male patients. METHODS: Infertile men (n = 433) were randomly assigned to exercise (n = 218) and non-exercise (n = 215) groups. The seminal markers of inflammation and oxidative stress, semen quality parameters, sperm DNA fragmentation, and pregnancy rate were measured at baseline, at the end of week 12, at the end of week 24, and at 7 and 30 days during recovery...
July 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28623442/counseling-interventions-delivered-in-women-with-breast-cancer-to-improve-health-related-quality-of-life-a-systematic-review
#13
REVIEW
V D'Egidio, C Sestili, M Mancino, I Sciarra, R Cocchiara, I Backhaus, A Mannocci, Alessandro De Luca, Federico Frusone, Massimo Monti, G La Torre
BACKGROUND: Higher survival rates for breast cancer patients have led to concerns in dealing with short- and long-term side effects. The most common complications are impairment of shoulder functions, pain, lymphedema, and dysesthesia of the injured arm; psychological consequences concern: emotional distress, anxiety, and depression, thereby, deeply impacting/affecting daily living activity, and health-related quality of life. OBJECTIVE: To perform a systematic review for assessing the efficacy or effectiveness of interventions aiming at improving health-related quality of life, return to daily activity, and correct lifestyles among breast cancer patients...
June 16, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28620703/epidemiology-and-biology-of-physical-activity-and-cancer-recurrence
#14
REVIEW
Christine M Friedenreich, Eileen Shaw, Heather K Neilson, Darren R Brenner
Physical activity is emerging from epidemiologic research as a lifestyle factor that may improve survival from colorectal, breast, and prostate cancers. However, there is considerably less evidence relating physical activity to cancer recurrence and the biologic mechanisms underlying this association remain unclear. Cancer patients are surviving longer than ever before, and fear of cancer recurrence is an important concern. Herein, we provide an overview of the current epidemiologic evidence relating physical activity to cancer recurrence...
June 15, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28620700/gender-varying-associations-between-physical-activity-intensity-and-mental-quality-of-life-in-older-cancer-survivors
#15
David E Conroy, Kathleen Y Wolin, Cindy K Blair, Wendy Demark-Wahnefried
PURPOSE: Physical activity can enhance quality of life in cancer survivors, but this conclusion is based largely on research linking moderate-to-vigorous physical activity with quality of life. Light-intensity physical activity may be more feasible than more strenuous exercise for many older cancer survivors. This study reports a secondary analysis of baseline data from a lifestyle behavior intervention trial and examines the hypothesis that older cancer survivors who engage in more light-intensity physical activity, independent of moderate-to-vigorous activity, will report better mental quality of life...
June 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28620308/the-effect-of-interdialytic-combined-resistance-and-aerobic-exercise-training-on-health-related-outcomes-in-chronic-hemodialysis-patients-the-tunisian-randomized-controlled-study
#16
Bechir Frih, Hamdi Jaafar, Wajdi Mkacher, Zohra Ben Salah, Mohamed Hammami, Ameur Frih
Background: Tunisia has the highest prevalence of hemodialysis patients compared to the other countries in North Africa. Dialysis centers rarely offer an exercise program to prevent physiological and psychological dialysis therapy-related alterations in chronic hemodialysis patients. Aim: To examine the effect of combined endurance-resistance training program on physiological and psychological outcomes in patients undergoing hemodialysis. Methods: We designed a single blinded, randomized, controlled study for a period of 4 months...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28619304/the-prevalence-rate-of-deviations-in-body-constitutions-and-related-factors-in-follow-up-stage-breast-cancer-patients-a-nationwide-study
#17
Shu-Chuan Amy Lin, Pei-Yi Chu, Li-Li Chen, Yi-Chang Su, Shin-Mae Wang
OBJECTIVES: The aim of this study was to apply a rigorous traditional Chinese medicine (TCM) body constitution questionnaire (BCQ) to survey the prevalence rate of deviations in body constitution and to explore the health-related lifestyle behavior factors of deviations in body constitution. DESIGN: A cross-sectional study was administered through postal mail. Subjects were recruited from a national organization for breast cancer patients (Taiwan Breast Cancer Alliance)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28617414/obesity
#18
REVIEW
Pedro González-Muniesa, Miguel-Angel Mártinez-González, Frank B Hu, Jean-Pierre Després, Yuji Matsuzawa, Ruth J F Loos, Luis A Moreno, George A Bray, J Alfredo Martinez
Excessive fat deposition in obesity has a multifactorial aetiology, but is widely considered the result of disequilibrium between energy intake and expenditure. Despite specific public health policies and individual treatment efforts to combat the obesity epidemic, >2 billion people worldwide are overweight or obese. The central nervous system circuitry, fuel turnover and metabolism as well as adipose tissue homeostasis are important to comprehend excessive weight gain and associated comorbidities. Obesity has a profound impact on quality of life, even in seemingly healthy individuals...
June 15, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28617170/adherence-of-heart-transplant-recipients-to-prescribed-medication-and-recommended-lifestyle-habits
#19
Y Brocks, A Zittermann, D Grisse, G Schmid-Ott, S Stock-Gießendanner, U Schulz, J Brakhage, A Benkler, J Gummert, Katharina Tigges-Limmer
INTRODUCTION: Nonadherence may cause severe health problems in heart transplant (HTx) recipients. RESEARCH QUESTIONS: The present study aimed to investigate adherence to prescribed medication and recommended lifestyle habits in post-HTx patients and to assess associations between adherence, quality of life (QOL), and psychological well-being. DESIGN: A questionnaire package was sent to all HTx patients from our clinic (n = 858) to answer questions anonymously on medication adherence, dietary recommendations (avoidance of raw animal products and ice cream), pet keeping (risk of zoonosis), anxiety and depression, QOL, and posttraumatic stress disorders...
June 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/28617071/an-endothelial-link-between-the-benefits-of-physical-exercise-in-dementia
#20
Lianne J Trigiani, Edith Hamel
The current absence of a disease-modifying treatment for Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) highlights the necessity for investigating the benefits of non-pharmacological approaches such as physical exercise (PE). Although evidence exists to support an association between regular PE and higher scores on cognitive function tests, and a slower rate of cognitive decline, there is no clear consensus on the underlying molecular mechanisms of the advantages of PE. This review seeks to summarize the positive effects of PE in human and animal studies while highlighting the vascular link between these benefits...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
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