Yingjie Shi, Emma Sprooten, Peter Mulders, Janna Vrijsen, Janita Bralten, Ditte Demontis, Anders D Børglum, G Bragi Walters, Kari Stefansson, Philip van Eijndhoven, Indira Tendolkar, Barbara Franke, Nina Roth Mota
The dense co-occurrence of psychiatric disorders questions the categorical classification tradition and motivates efforts to establish dimensional constructs with neurobiological foundations that transcend diagnostic boundaries. In this study, we examined the genetic liability for eight major psychiatric disorder phenotypes under both a disorder-specific and a transdiagnostic framework. The study sample (n = 513) was deeply phenotyped, consisting of 452 patients from tertiary care with mood disorders, anxiety disorders (ANX), attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders, and/or substance use disorders (SUD) and 61 unaffected comparison individuals...
June 19, 2023: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics